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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res. 2014 Jan; 12(1):48-57.
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PubMed
subject areas
6-Aminonicotinamide
Animals
Apoptosis Regulatory Proteins
Autophagy
Caspase 1
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Chloroquine
Enzyme Inhibitors
Glucose
Hydroxychloroquine
Lysosomal-Associated Membrane Protein 2
Mice
Mice, Inbred A
Mice, Transgenic
Microtubule-Associated Proteins
Mitochondria
Multiprotein Complexes
NF-kappa B
Oxygen Consumption
Pentose Phosphate Pathway
Reactive Oxygen Species
RNA Interference
RNA, Small Interfering
Signal Transduction
Teratogens
TOR Serine-Threonine Kinases
Tumor Suppressor Proteins
authors with profiles
David Joseph Kwiatkowski, M.D., Ph.D.
Elizabeth Petri Henske, M.D.
John M Asara, Ph.D.
Carmen Priolo, Ph.D., M.D.