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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
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A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell. 2013 Jun 06; 12(6):713-26.
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PubMed
subject areas
Amyotrophic Lateral Sclerosis
Animals
Benzazepines
Cell Differentiation
Cell Survival
Cells, Cultured
Cholestenones
Embryonic Stem Cells
Glycogen Synthase Kinase 3
Humans
Indoles
Induced Pluripotent Stem Cells
Intracellular Signaling Peptides and Proteins
Mice
Mice, Transgenic
Motor Neurons
Mutation
Protein Kinase Inhibitors
Protein-Serine-Threonine Kinases
Structure-Activity Relationship
Superoxide Dismutase
authors with profiles
Brian Jason Wainger, M.D., Ph.D.
Lee Rubin, Ph.D.
Clifford Woolf, Ph.D., M.B.,B.Ch.