PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17).
Bullinger L, Schlenk RF, Götz M, Botzenhardt U, Hofmann S, Russ AC, Babiak A, Zhang L, Schneider V, Döhner K, Schmitt M, Döhner H, Greiner J. PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17). Clin Cancer Res. 2013 May 01; 19(9):2562-71.
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Antigens, Neoplasm
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Antineoplastic Combined Chemotherapy Protocols
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Cell Differentiation
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Cell Proliferation
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Chromosomes, Human, Pair 15
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Chromosomes, Human, Pair 17
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Clinical Trials, Phase III as Topic
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Gene Expression Regulation, Leukemic
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Gene Knockdown Techniques
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Humans
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K562 Cells
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Kaplan-Meier Estimate
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Leukemia, Myeloid, Acute
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Randomized Controlled Trials as Topic
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Receptors, Retinoic Acid
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RNA, Small Interfering
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Signal Transduction
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Translocation, Genetic
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Treatment Outcome
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Tretinoin