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HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.
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HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14391-6.
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PubMed
subject areas
Apoptosis Regulatory Proteins
Basic Helix-Loop-Helix Transcription Factors
Caspase 3
Cell Cycle
Cell Death
Cell Hypoxia
Cell Line, Tumor
DNA Damage
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunoblotting
Microscopy, Fluorescence
Neoplasms
Oligonucleotide Array Sequence Analysis
Proto-Oncogene Proteins
Radiation, Ionizing
Reactive Oxygen Species
Reverse Transcriptase Polymerase Chain Reaction
RNA Interference
Signal Transduction
Tumor Suppressor Protein p53
authors with profiles
Amar Jayprakash Majmundar, M.D.,Ph.D.