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The Preconception Intervention for Health Reproduction (PIPER) Study


Infertility and pregnancy loss are common, costly, and emotional outcomes that affect both fertile and subfertile couples. Evidence shows that the preconception period is a window of susceptibility and exposure to environmental chemicals such phthalates and phenols in both men and women before conception adversely impacts fertility and pregnancy. Phthalates and phenols are found in food and everyday consumer products, and are among the environmental pollutants whose exposures individuals have some agency to modify and control. The potential for modulation means that the preconception period offers an opportunity to intervene and support reproductive health across the lifecourse. Couples trying to conceive desire information on how to improve their preconception health; yet, clinicians have little to offer in terms of evidence-based prevention to support their fertility potential. The aim of the Preconception Intervention Program for Healthy Reproduction (PIPER) Project is to develop, implement, and evaluate a preconception intervention program to reduce male and female phthalate and phenol exposures from diet and personal care products in couples attempting conception at the Beth Israel Deaconess Medical Center. The PIPER Project seeks to address major gaps in the translation of existing observational evidence into prevention focused on promoting environmental-reproductive health in couples during preconception.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.