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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019 06 03; 10(1):2400.
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subject areas
Animals
Azepines
Basic Helix-Loop-Helix Transcription Factors
Cell Cycle
Cell Cycle Proteins
Cell Line, Tumor
Cell Lineage
Cerebellar Neoplasms
Cyclin D2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Drug Resistance, Neoplasm
Gene Expression Profiling
Humans
Medulloblastoma
Mice
Neural Stem Cells
Neurogenesis
Proteins
Proto-Oncogene Proteins c-myc
S Phase
Triazoles
authors with profiles
Pratiti Bandopadhayay, Ph.D., M.B.,B.S.
Keith Lloyd Ligon, M.D., Ph.D.
Kimberly Stegmaier, M.D.
Frank Dubois, M.D.
Melanie Pages, M.D.
Michael Bruce Yaffe, M.D., Ph.D.
Rameen Beroukhim, M.D., Ph.D.
William Chun Hahn, Ph.D., M.D.
Sandro Santagata, Ph.D., M.D.
Shannon Coy, M.D.