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Is collagenase (matrix metalloproteinase-1) necessary for bone and other connective tissue remodeling?

Is collagenase (matrix metalloproteinase-1) necessary for bone and other connective tissue remodeling? Clin Orthop Relat Res. 1995 Apr; (313):47-53.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.