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Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway.
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Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway.
Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway. Hypertension. 2005 Apr; 45(4):538-44.
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PubMed
subject areas
Animals
Cell Adhesion Molecules
Cytoprotection
Glomerulosclerosis, Focal Segmental
Hypertension
Intracellular Signaling Peptides and Proteins
Kidney
Male
Mitogen-Activated Protein Kinases
Nitric Oxide Synthase
Nitric Oxide Synthase Type III
Protein Kinase C
Protein Kinase C-epsilon
Protein Kinase Inhibitors
Protein-Serine-Threonine Kinases
Proteinuria
Rats
Rats, Inbred Dahl
Receptors, LDL
Receptors, Oxidized LDL
rho-Associated Kinases
Ribosomal Protein S6 Kinases, 90-kDa
RNA, Messenger
Scavenger Receptors, Class E
Spironolactone
authors with profiles
Maristela Lika Onozato, Ph.D., M.D.