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IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.
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IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol. 2003 Jul 15; 171(2):608-15.
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PubMed
subject areas
Adjuvants, Immunologic
Animals
Antigens, Neoplasm
Cancer Vaccines
Cell Division
Cytotoxicity, Immunologic
Female
Growth Inhibitors
Immunity, Active
Immunity, Innate
Interferon-gamma
Interleukin-10
Interleukin-12
Interleukin-21 Receptor alpha Subunit
Interleukin-4
Interleukins
Melanoma, Experimental
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Mice, SCID
Perforin
Pore Forming Cytotoxic Proteins
Receptors, Interleukin
Receptors, Interleukin-21
Sarcoma, Experimental
T-Lymphocytes, Cytotoxic
Transduction, Genetic
Tumor Cells, Cultured
authors with profiles
Michael Grusby, Ph.D.