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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28; 463(7280):501-6.
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PubMed
subject areas
Animals
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Benzamides
Binding Sites
Bone Marrow Transplantation
Cell Line, Tumor
Crystallization
Disease Models, Animal
Drug Resistance, Neoplasm
Female
Fusion Proteins, bcr-abl
Humans
Inhibitory Concentration 50
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Mass Spectrometry
Mice
Models, Molecular
Mutation
Piperazines
Protein Structure, Tertiary
Pyrimidines
Transplantation, Heterologous
authors with profiles
George Quentin Daley, M.D., Ph.D.