Harvard Catalyst Profiles

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Discovery of isoxazole analogues of sazetidine-A as selective a4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.

Liu J, Yu LF, Eaton JB, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D, Ghavami A, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP. Discovery of isoxazole analogues of sazetidine-A as selective a4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem. 2011 Oct 27; 54(20):7280-8.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.