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Synthesis and evaluation of compounds that induce readthrough of premature termination codons.
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Synthesis and evaluation of compounds that induce readthrough of premature termination codons.
Synthesis and evaluation of compounds that induce readthrough of premature termination codons. Bioorg Med Chem Lett. 2011 Oct 01; 21(19):5842-8.
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subject areas
Ataxia Telangiectasia
Cell Cycle Proteins
Cell Line
Codon, Nonsense
Codon, Terminator
DNA-Binding Proteins
Drug Design
Drug Evaluation, Preclinical
Furans
High-Throughput Screening Assays
Molecular Structure
Molecular Targeted Therapy
Mutation
Open Reading Frames
Peptide Chain Termination, Translational
Protein Biosynthesis
Protein-Serine-Threonine Kinases
Ribosomes
RNA, Messenger
Structure-Activity Relationship
Thiazoles
Transcriptional Activation
Tumor Suppressor Proteins