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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.
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PubMed
subject areas
Adaptor Proteins, Vesicular Transport
Animals
Aorta
Apolipoproteins E
Calgranulin A
Cathepsin K
Cathepsins
Cell Membrane
Cells, Cultured
Cholesterol
E-Box Elements
Endosomes
Enzyme Induction
Humans
Intracellular Signaling Peptides and Proteins
Macrophages
Matrix Metalloproteinase 14
Matrix Metalloproteinase 8
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Microphthalmia-Associated Transcription Factor
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Promoter Regions, Genetic
Proteins
rab GTP-Binding Proteins
Receptor Activator of Nuclear Factor-kappa B
S100 Proteins
Signal Transduction
Time Factors
Toll-Like Receptor 3
Toll-Like Receptor 4
authors with profiles
Peter Libby, M.D.
Masanori Aikawa, Ph.D., M.D.
Andriy Samokhin, Ph.D.