Amtul Aala, M.B.,B.S.AmtulAala

Beth Israel Deaconess Medical CenterDept of Medicine, Division of Nephrology, LMOB-7330 Brookline AveBoston, MA 02215617/632-1099

1BIDMCBeth Israel Deaconess Medical CenterMedicineNephrologyInstructor in MedicineInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/41209166A Rare Case of Anti-glutamic Acid Decarboxylase 65 Autoimmune Encephalitis Followed by Acute Graft-Versus-Host Disease in Simultaneous Kidney and Pancreas Transplant. Kidney Med. 2025 Nov; 7(11):101112.Dale LA, Prete A, Puyleart A, Qian X, Siddiqi O, Le-Mahajan A, Aala A. Kidney Med2025 Nov7(11):101112http://www.ncbi.nlm.nih.gov/pubmed/38699983A comparative analysis of kidney allograft outcomes in steroid use versus steroid discontinuation after basiliximab and ATG induction: A UNOS database study. Clin Nephrol. 2024 Jul; 102:39-50.Nissaisorakarn P, Patel H, Cardarelli F, Amtul A. Clin Nephrol2024 Jul102:39-50http://www.ncbi.nlm.nih.gov/pubmed/38195285Frailty and Kidney Transplant Waitlisting: A Single-Center Experience. Transplant Proc. 2024 Jan-Feb; 56(1):37-43.Xu EJ, Kyriazis P, Pawar A, Pavlakis M, Aala A. Transplant Proc2024 Jan-Feb56(1):37-43http://www.ncbi.nlm.nih.gov/pubmed/38094134Medical and Surgical Management of the Failed Pancreas Transplant. Transplant Direct. 2024 Jan; 10(1):e1543.Casey MJ, Murakami N, Ong S, Adler JT, Singh N, Murad H, Parajuli S, Concepcion BP, Lubetzky M, Pavlakis M, Woodside KJ, Faravardeh A, Basu A, Tantisattamo E, Aala A, Gruessner AC, Dadhania DM, Lentine KL, Cooper M, Parsons RF, Alhamad T. Transplant Direct2024 Jan10(1):e1543http://www.ncbi.nlm.nih.gov/pubmed/35445660Protocol-based donor-derived cell-free DNA surveillance in kidney transplant recipients: A single-center experience. Clin Nephrol. 2022 Aug; 98(2):65-74.Nissaisorakarn P, Patel H, Amtul A, Pavlakis M. Clin Nephrol2022 Aug98(2):65-74http://www.ncbi.nlm.nih.gov/pubmed/34115439The failing kidney allograft: A review and recommendations for the care and management of a complex group of patients. Am J Transplant. 2021 09; 21(9):2937-2949.Lubetzky M, Tantisattamo E, Molnar MZ, Lentine KL, Basu A, Parsons RF, Woodside KJ, Pavlakis M, Blosser CD, Singh N, Concepcion BP, Adey D, Gupta G, Faravardeh A, Kraus E, Ong S, Riella LV, Friedewald J, Wiseman A, Aala A, Dadhania DM, Alhamad T. Am J Transplant2021 0921(9):2937-2949http://www.ncbi.nlm.nih.gov/pubmed/34922692Novel Glucose-Lowering Therapies in the Setting of Solid Organ Transplantation. Adv Chronic Kidney Dis. 2021 07; 28(4):361-370.Nissaisorakarn P, Pavlakis M, Aala A. Adv Chronic Kidney Dis2021 0728(4):361-370http://www.ncbi.nlm.nih.gov/pubmed/33490381Utility of Serial Donor-derived Cell-free DNA Measurements for Detecting Allograft Rejection in a Kidney Transplant Recipient After PD-1 Checkpoint Inhibitor Administration. Transplant Direct. 2021 Feb; 7(2):e656.Lakhani L, Alasfar S, Bhalla A, Aala A, Rosenberg A, Ostrander D, Schollenberger MD, Brennan DC, Lipson EJ. Transplant Direct2021 Feb7(2):e656http://www.ncbi.nlm.nih.gov/pubmed/32615995Angiotensin II receptor 1 antibodies associate with post-transplant focal segmental glomerulosclerosis and proteinuria. BMC Nephrol. 2020 07 02; 21(1):253.Abuzeineh M, Aala A, Alasfar S, Alachkar N. BMC Nephrol2020 07 0221(1):253http://www.ncbi.nlm.nih.gov/pubmed/30300281Everyday People Sing a Simple Song: Establishing a Core Outcome for Life Participation. Transplantation. 2019 06; 103(6):1078-1079.Aala A, Brennan DC. Transplantation2019 06103(6):1078-1079http://www.ncbi.nlm.nih.gov/pubmed/29884733Transformation in Immunosuppression: Are We Ready for it? J Am Soc Nephrol. 2018 07; 29(7):1791-1792.Aala A, Brennan DC. J Am Soc Nephrol2018 0729(7):1791-1792http://www.ncbi.nlm.nih.gov/pubmed/29277506High-Output Cardiac Failure and Coronary Steal With an Arteriovenous Fistula. Am J Kidney Dis. 2018 06; 71(6):896-903.Aala A, Sharif S, Parikh L, Gordon PC, Hu SL. Am J Kidney Dis2018 0671(6):896-903Kidney Transplantation71.135184071165450e+0002018-06-08T00:00:002024-07-01T00:00:00Basiliximab18.664144007665757e-0012024-07-01T00:00:002024-07-01T00:00:00Antilymphocyte Serum17.559299819788088e-0012024-07-01T00:00:002024-07-01T00:00:00Vascular Access Devices15.005479637557402e-0012017-12-23T00:00:002017-12-23T00:00:00Nephrology14.544300118811249e-0012019-06-01T00:00:002019-06-01T00:00:00Coronary Restenosis14.433056738523152e-0012017-12-23T00:00:002017-12-23T00:00:00Graft Rejection34.111702317025061e-0012020-07-02T00:00:002024-07-01T00:00:00Graft Survival13.996676585097934e-0012024-07-01T00:00:002024-07-01T00:00:00Frailty13.601332175834699e-0012024-01-08T00:00:002024-01-08T00:00:00Immunosuppressive Agents23.596171005071837e-0012021-07-19T00:00:002024-07-01T00:00:00Organ Transplantation13.380044699810913e-0012021-07-01T00:00:002021-07-01T00:00:00Sodium-Glucose Transporter 2 Inhibitors13.240996124373209e-0012021-07-01T00:00:002021-07-01T00:00:00Renal Dialysis22.998465120654958e-0012017-12-23T00:00:002021-07-19T00:00:00Kidney Failure, Chronic22.918824662195357e-0012017-12-23T00:00:002020-07-02T00:00:00Allografts21.769778407059965e-0012021-07-19T00:00:002024-07-01T00:00:00Receptor, Angiotensin, Type 111.542616796973395e-0012020-07-02T00:00:002020-07-02T00:00:00Steroids11.484670972739602e-0012024-07-01T00:00:002024-07-01T00:00:00Coronary Artery Disease11.375109690343897e-0012017-12-23T00:00:002017-12-23T00:00:00Mammary Arteries11.317926912303069e-0012017-12-23T00:00:002017-12-23T00:00:00Cell-Free Nucleic Acids11.304770998541014e-0012022-08-01T00:00:002022-08-01T00:00:00Diabetes Mellitus, Type 211.298709183000824e-0012021-07-01T00:00:002021-07-01T00:00:00Proteinuria11.294635902672805e-0012020-07-02T00:00:002020-07-02T00:00:00Glomerulosclerosis, Focal Segmental11.285482589586770e-0012020-07-02T00:00:002020-07-02T00:00:00Calcineurin Inhibitors11.263441205038522e-0012018-06-08T00:00:002018-06-08T00:00:00Recombinant Fusion Proteins11.155720704848418e-0012024-07-01T00:00:002024-07-01T00:00:00Everolimus11.142451253915776e-0012018-06-08T00:00:002018-06-08T00:00:00Cardiac Output11.138996084028475e-0012017-12-23T00:00:002017-12-23T00:00:00Cardiovascular Diseases11.132554586658736e-0012021-07-01T00:00:002021-07-01T00:00:00Tacrolimus11.071702977578830e-0012018-06-08T00:00:002018-06-08T00:00:00Heart Failure11.005486667630288e-0012017-12-23T00:00:002017-12-23T00:00:00Immunosuppression Therapy19.486953637009389e-0022018-06-08T00:00:002018-06-08T00:00:00Antibodies19.374196101924713e-0022020-07-02T00:00:002020-07-02T00:00:00Diabetic Nephropathies18.189144526879752e-0022017-12-23T00:00:002017-12-23T00:00:00Consensus18.109656903436188e-0022019-06-01T00:00:002019-06-01T00:00:00Glucose17.736905846814458e-0022021-07-01T00:00:002021-07-01T00:00:00Postoperative Complications27.339388223023949e-0022020-07-02T00:00:002024-01-08T00:00:00Coronary Artery Bypass17.208363157978352e-0022017-12-23T00:00:002017-12-23T00:00:00Databases, Factual17.113818666541337e-0022024-07-01T00:00:002024-07-01T00:00:00Hypoglycemic Agents16.726727559822096e-0022021-07-01T00:00:002021-07-01T00:00:00Reoperation16.241019069087514e-0022017-12-23T00:00:002017-12-23T00:00:00Treatment Outcome25.318096656395097e-0022017-12-23T00:00:002024-07-01T00:00:00Outcome Assessment, Health Care15.183168988936162e-0022019-06-01T00:00:002019-06-01T00:00:00Time Factors14.692830006577794e-0022024-07-01T00:00:002024-07-01T00:00:00Disease Progression14.072322804079676e-0022017-12-23T00:00:002017-12-23T00:00:00Retrospective Studies33.884747620776370e-0022020-07-02T00:00:002024-07-01T00:00:00Humans73.845206926199418e-0022017-12-23T00:00:002024-07-01T00:00:00Viremia13.639933942571789e-0022022-08-01T00:00:002022-08-01T00:00:00Transplant Recipients13.286021020699377e-0022022-08-01T00:00:002022-08-01T00:00:00Risk Factors13.077799949280377e-0022024-01-08T00:00:002024-01-08T00:00:00Risk Assessment13.029916885929832e-0022017-12-23T00:00:002017-12-23T00:00:00Follow-Up Studies13.013012505173498e-0022017-12-23T00:00:002017-12-23T00:00:00Male32.647804636380750e-0022017-12-23T00:00:002024-07-01T00:00:00Transplantation, Homologous12.368049682946214e-0022021-07-19T00:00:002021-07-19T00:00:00Tissue Donors12.290294675329325e-0022022-08-01T00:00:002022-08-01T00:00:00Adult22.217526571880595e-0022020-07-02T00:00:002024-07-01T00:00:00Middle Aged22.217378958886212e-0022020-07-02T00:00:002024-07-01T00:00:00Recurrence11.697377289749735e-0022020-07-02T00:00:002020-07-02T00:00:00Female21.632676174358469e-0022020-07-02T00:00:002024-07-01T00:00:00Kidney11.467009046758508e-0022021-07-19T00:00:002021-07-19T00:00:00Aged11.325262696207370e-0022017-12-23T00:00:002017-12-23T00:00:00Biomarkers11.005675830602356e-0022022-08-01T00:00:002022-08-01T00:00:00Shullamite Giovanna Ababioh, M.D.ShullamiteAbabioh

Beth Israel Deaconess Medical CenterPsychiatry, Rabb 2, c/o Colleen Cusick330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterPsychiatryClinical Fellow in PsychiatryFellow or Post DocVictoria Elena Abadi Ron, M.D.VictoriaAbadi Ron

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyResearch Fellow in MedicineFellow or Post DocDarren Barney Abbas, M.D.DarrenAbbas

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryClinical Fellow in SurgeryFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41396208Spotlight in Plastic Surgery: April 2026. Plast Reconstr Surg. 2026 Apr 01; 157(4):783-786.Phillips BT, Abbas DB, Chou J, Foppiani JA, Mahmoud AA, Marinello G, Moura F, Nassar RA, Rizvi I, Saad C, Szulia A, White-Dzuro CG, Williams S, Yesantharao P. Plast Reconstr Surg2026 Apr 01157(4):783-786http://www.ncbi.nlm.nih.gov/pubmed/41120571Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis. Nat Biomed Eng. 2025 Oct 21.Chen K, Griffin M, Henn D, Berryman KS, Sivaraj D, Kussie HC, Bonham CA, McKenna E, Mora Pinos MG, Alsharif AM, Saenz F, Matthews NE, Jafri M, Yasmeh JP, Borrelli MR, Huskins S, Steele S, Knochel AB, Singh M, Hostler AC, Leeolou M, Hahn WW, Perrault D, Abbas D, Guardino N, Thomas B, Barrera JA, Noishiki C, Trotsyuk AA, Padmanabhan J, Januszyk M, Khreiss M, Longaker MT, Gurtner GC. Nat Biomed Eng2025 Oct 21http://www.ncbi.nlm.nih.gov/pubmed/40108456Histological signatures map anti-fibrotic factors in mouse and human lungs. Nature. 2025 May; 641(8064):993-1004.Guo JL, Griffin M, Yoon JK, Lopez DM, Zhu Y, Lu JM, Mikos G, Parker JBL, Mascharak S, Brenac C, Guardino NJ, Abbas DB, Li DJ, Valencia C, Liang NE, Januszyk M, Chang HY, Wan DC, Desai TJ, Longaker MT. Nature2025 May641(8064):993-1004http://www.ncbi.nlm.nih.gov/pubmed/39970235Inhibiting mechanotransduction prevents scarring and yields regeneration in a large animal model. Sci Transl Med. 2025 Feb 19; 17(786):eadt6387.Mascharak S, Griffin M, Talbott HE, Guo JL, Parker J, Morgan AG, Valencia C, Kuhnert MM, Li DJ, Liang NE, Kratofil RM, Daccache JA, Sidhu I, Davitt MF, Guardino N, Lu JM, Abbas DB, Deleon NMD, Lavin CV, Adem S, Khan A, Chen K, Henn D, Spielman A, Cotterell A, Akras D, Downer M, Tevlin R, Lorenz HP, Gurtner GC, Januszyk M, Naik S, Wan DC, Longaker MT. Sci Transl Med2025 Feb 1917(786):eadt6387http://www.ncbi.nlm.nih.gov/pubmed/40411810Spotlight in Plastic Surgery: October 2024. Plast Reconstr Surg. 2024 Oct 01; 154(4):911-914.Phillips BT, Abbas DB, Alessandri-Bonetti M, AlSahli A, Araya S, Franco-Mesa C, Marinello G, Millesi E, Moura F, Panayi AC, Toyoda Y, Zapatero ZD. Plast Reconstr Surg2024 Oct 01154(4):911-914http://www.ncbi.nlm.nih.gov/pubmed/40881998Spotlight in Plastic Surgery: October 2024. Plast Reconstr Surg. 2024 Oct 01; 154(4):911-914.Phillips BT, Abbas DB, Alessandri-Bonetti M, AlSahli A, Araya S, Franco-Mesa C, Marinello G, Millesi E, Moura F, Panayi AC, Toyoda Y, Zapatero ZD. Plast Reconstr Surg2024 Oct 01154(4):911-914http://www.ncbi.nlm.nih.gov/pubmed/38613357Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin. J Cell Mol Med. 2024 04; 28(8):e18306.Berry CE, Abbas DB, Griffin M, Lintel H, Guo J, Kameni L, Churukian AA, Fazilat AZ, Chen K, Gurtner GC, Longaker MT, Momeni A, Wan DC. J Cell Mol Med2024 0428(8):e18306http://www.ncbi.nlm.nih.gov/pubmed/38464040A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injections. Res Sq. 2024 Mar 01.Talbott HE, Griffin MF, Mascharak S, Parker JBL, Kuhnert MM, Guo JL, Diaz Deleon NM, Lavin C, Abbas D, Guardino N, Morgan A, Valencia C, Cotterell A, Longaker MT, Wan DC. Res Sq2024 Mar 01http://www.ncbi.nlm.nih.gov/pubmed/37817924Quality Assessment of Online Resources for Gender-affirming Surgery. Plast Reconstr Surg Glob Open. 2023 Oct; 11(10):e5306.Berry CE, Fazilat AZ, Churukian AA, Abbas DB, Griffin M, Downer M, Januszyk M, Momeni A, Morrison SD, Wan DC. Plast Reconstr Surg Glob Open2023 Oct11(10):e5306http://www.ncbi.nlm.nih.gov/pubmed/37066136Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition. bioRxiv. 2023 Apr 04.Griffin MF, Talbott HE, Guardino NJ, Guo JL, Spielman AF, Chen K, Parker JBL, Mascharak S, Henn D, Liang N, King M, Cotterell AC, Bauer-Rowe KE, Abbas DB, Diaz Deleon NM, Sivaraj D, Fahy EJ, Downer M, Akras D, Berry C, Cook J, Quarto N, Klein OD, Lorenz HP, Gurtner GC, Januszyk M, Wan DC, Longaker MT. bioRxiv2023 Apr 04http://www.ncbi.nlm.nih.gov/pubmed/36988644Establishing a Xenograft Model with CD-1 Nude Mice to Study Human Skin Wound Repair. Plast Reconstr Surg. 2024 01 01; 153(1):121-128.Abbas DB, Griffin M, Fahy EJ, Spielman AF, Guardino NJ, Pu A, Lintel H, Lorenz HP, Longaker MT, Wan DC. Plast Reconstr Surg2024 01 01153(1):121-128http://www.ncbi.nlm.nih.gov/pubmed/36484112Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model. Wound Repair Regen. 2023 01; 31(1):77-86.Lintel H, Abbas DB, Mackay DJ, Griffin M, Lavin CV, Berry CE, Guardino NJ, Guo JL, Momeni A, Mackay DR, Longaker MT, Wan DC. Wound Repair Regen2023 0131(1):77-86http://www.ncbi.nlm.nih.gov/pubmed/36345216Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis. Adv Wound Care (New Rochelle). 2024 05; 13(5):235-252.Berry CE, Abbas DB, Lintel HA, Churukian AA, Griffin M, Guo JL, Cotterell AC, Parker JBL, Downer MA, Longaker MT, Wan DC. Adv Wound Care (New Rochelle)2024 0513(5):235-252http://www.ncbi.nlm.nih.gov/pubmed/35468179Response to: Vitamin E Improves Volumetry and Regenerative Effects of Fat Grafting. Aesthet Surg J. 2022 08 01; 42(8):NP567-NP568.Abbas DB, Wan DC. Aesthet Surg J2022 08 0142(8):NP567-NP568http://www.ncbi.nlm.nih.gov/pubmed/35350074Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis. Aesthet Surg J. 2022 08 01; 42(8):946-955.Abbas DB, Lavin CV, Fahy EJ, Griffin M, Guardino NJ, Nazerali RS, Nguyen DH, Momeni A, Longaker MT, Wan DC. Aesthet Surg J2022 08 0142(8):946-955http://www.ncbi.nlm.nih.gov/pubmed/35715816Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin. J Transl Med. 2022 06 17; 20(1):274.Lintel H, Abbas DB, Lavin CV, Griffin M, Guo JL, Guardino N, Churukian A, Gurtner GC, Momeni A, Longaker MT, Wan DC. J Transl Med2022 06 1720(1):274http://www.ncbi.nlm.nih.gov/pubmed/35280050Tension offloading improves cutaneous scar formation in Achilles tendon repair. J Surg Case Rep. 2022 Mar; 2022(3):rjac066.Abbas DB, Lintel H, Griffin M, Guardino NJ, Guo JL, Spielman AF, Cotterell AC, Parker JBL, Januszyk M, Wan DC. J Surg Case Rep2022 Mar2022(3):rjac066http://www.ncbi.nlm.nih.gov/pubmed/34470520Understanding Scarring in the Oral Mucosa. Adv Wound Care (New Rochelle). 2022 10; 11(10):537-547.Griffin MF, Fahy EJ, King M, Guardino N, Chen K, Abbas DB, Lavin CV, Diaz Deleon NM, Lorenz HP, Longaker MT, Wan DC. Adv Wound Care (New Rochelle)2022 1011(10):537-547http://www.ncbi.nlm.nih.gov/pubmed/34470542Standardizing Dimensionless Cutometer Parameters to Determine In Vivo Elasticity of Human Skin. Adv Wound Care (New Rochelle). 2022 06; 11(6):297-310.Abbas DB, Lavin CV, Fahy EJ, Griffin M, Guardino N, King M, Chen K, Lorenz PH, Gurtner GC, Longaker MT, Momeni A, Wan DC. Adv Wound Care (New Rochelle)2022 0611(6):297-310http://www.ncbi.nlm.nih.gov/pubmed/34612609A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis. J Cell Mol Med. 2021 11; 25(21):10028-10038.Lavin CV, Abbas DB, Fahy EJ, Lee DK, Griffin M, Diaz Deleon NM, Mascharak S, Chen K, Momeni A, Gurtner GC, Longaker MT, Wan DC. J Cell Mol Med2021 1125(21):10028-10038http://www.ncbi.nlm.nih.gov/pubmed/34582109Angiogenic CD34+CD146+ adipose-derived stromal cells augment recovery of soft tissue after radiotherapy. J Tissue Eng Regen Med. 2021 12; 15(12):1105-1117.Deleon NMD, Adem S, Lavin CV, Abbas DB, Griffin M, King ME, Borrelli MR, Patel RA, Fahy EJ, Lee D, Shen AH, Momeni A, Longaker MT, Wan DC. J Tissue Eng Regen Med2021 1215(12):1105-1117http://www.ncbi.nlm.nih.gov/pubmed/33833152The Adrenergic System in Plastic and Reconstructive Surgery: Physiology and Clinical Considerations. Ann Plast Surg. 2021 10 01; 87(4):e62-e70.Fahy EJ, Griffin M, Lavin C, Abbas D, Longaker MT, Wan D. Ann Plast Surg2021 10 0187(4):e62-e70http://www.ncbi.nlm.nih.gov/pubmed/34346243Decellularized Adipose Matrices Can Alleviate Radiation-Induced Skin Fibrosis. Adv Wound Care (New Rochelle). 2022 10; 11(10):524-536.Adem S, Abbas DB, Lavin CV, Fahy EJ, Griffin M, Diaz Deleon NM, Borrelli MR, Mascharak S, Shen AH, Patel RA, Longaker MT, Nazerali RS, Wan DC. Adv Wound Care (New Rochelle)2022 1011(10):524-536http://www.ncbi.nlm.nih.gov/pubmed/34075816A Systematic Review of Mandibular Distraction Osteogenesis Versus Orthodontic Airway Plate for Airway Obstruction Treatment in Pierre Robin Sequence. Cleft Palate Craniofac J. 2022 Mar; 59(3):365-376.Abbas DB, Lavin C, Fahy EJ, Choo H, Truong MT, Bruckman KC, Khosla RK, Lorenz HP, Momeni A, Wan DC. Cleft Palate Craniofac J2022 Mar59(3):365-376http://www.ncbi.nlm.nih.gov/pubmed/33960204Readability of Online Patient Information Relating to Cleft Palate Surgery. Cleft Palate Craniofac J. 2022 Mar; 59(3):330-335.Lavin CV, Fahy EJ, Abbas DB, Griffin M, Deleon NMD, Lee DK, Khosla RK, Bruckman K, Lorenz HP, Wan DC. Cleft Palate Craniofac J2022 Mar59(3):330-335Cicatrix48.120208732161497e-0012021-10-12T00:00:002025-02-19T00:00:00Skin97.943336155828531e-0012021-09-06T00:00:002024-04-01T00:00:00Vitamin E26.932298141246576e-0012022-08-01T00:00:002022-08-01T00:00:00Rejuvenation16.528272319593005e-0012022-08-01T00:00:002022-08-01T00:00:00Adipose Tissue56.351499648555661e-0012021-09-06T00:00:002022-12-09T00:00:00Radiation Fibrosis Syndrome46.343473797113552e-0012021-10-05T00:00:002024-04-01T00:00:00Skin Aging16.206510285054933e-0012021-10-08T00:00:002021-10-08T00:00:00Pierre Robin Syndrome15.976536582446517e-0012021-06-02T00:00:002021-06-02T00:00:00Osteogenesis, Distraction15.735228388247060e-0012021-06-02T00:00:002021-06-02T00:00:00Wound Healing55.683559478575466e-0012021-10-12T00:00:002025-02-19T00:00:00Deferoxamine35.464870426341191e-0012021-10-06T00:00:002024-04-01T00:00:00Airway Obstruction14.853156684786815e-0012021-06-02T00:00:002021-06-02T00:00:00Graft Survival13.499505991583227e-0012022-08-01T00:00:002022-08-01T00:00:00Mice, Nude53.392646944084162e-0012021-09-06T00:00:002025-02-19T00:00:00Radiation Injuries22.205179923494007e-0012022-06-17T00:00:002022-12-09T00:00:00Surgical Wound11.792415665490888e-0012022-12-14T00:00:002022-12-14T00:00:00Heterografts21.784416180783613e-0012021-10-05T00:00:002023-03-27T00:00:00Fibrosis31.684605800966614e-0012021-09-06T00:00:002022-12-09T00:00:00Pulmonary Fibrosis11.673832199578039e-0012025-03-19T00:00:002025-03-19T00:00:00Skin Physiological Phenomena11.652267728543007e-0012021-10-08T00:00:002021-10-08T00:00:00Radiation, Ionizing11.641430567261222e-0012021-10-06T00:00:002021-10-06T00:00:00Dermis11.594119331592169e-0012021-10-06T00:00:002021-10-06T00:00:00X-Ray Microtomography11.576593171173822e-0012022-08-01T00:00:002022-08-01T00:00:00Elasticity11.526672770268432e-0012021-10-08T00:00:002021-10-08T00:00:00Surgery, Oral11.493450265727063e-0012021-05-07T00:00:002021-05-07T00:00:00Mechanotransduction, Cellular11.483735679582783e-0012025-02-19T00:00:002025-02-19T00:00:00Idiopathic Pulmonary Fibrosis11.477706472762033e-0012025-03-19T00:00:002025-03-19T00:00:00Mesenchymal Stem Cell Transplantation11.242637739015376e-0012021-10-05T00:00:002021-10-05T00:00:00Mandible11.239314790553284e-0012021-06-02T00:00:002021-06-02T00:00:00Regeneration11.185772913557051e-0012025-02-19T00:00:002025-02-19T00:00:00Cleft Palate11.182585053737908e-0012021-05-07T00:00:002021-05-07T00:00:00Mice101.154037117190830e-0012021-09-06T00:00:002025-03-19T00:00:00Surgery, Plastic11.087814507625997e-0012021-10-01T00:00:002021-10-01T00:00:00Health Literacy11.084542780327750e-0012021-05-07T00:00:002021-05-07T00:00:00Disease Models, Animal49.049273360626307e-0022022-12-14T00:00:002025-03-19T00:00:00Animals118.736450635053067e-0022021-09-06T00:00:002025-03-19T00:00:00Mesenchymal Stem Cells18.406214966175338e-0022021-10-05T00:00:002021-10-05T00:00:00Plastic Surgery Procedures16.896004869438926e-0022021-10-01T00:00:002021-10-01T00:00:00Cytokines16.563035834856390e-0022022-08-01T00:00:002022-08-01T00:00:00Lung16.081962800521500e-0022025-03-19T00:00:002025-03-19T00:00:00Artificial Intelligence15.997127728722741e-0022023-03-27T00:00:002023-03-27T00:00:00Humans135.812151254914635e-0022021-05-07T00:00:002025-03-19T00:00:00Serpin E215.695382822355359e-0022025-03-19T00:00:002025-03-19T00:00:00Verteporfin15.483511231824553e-0022025-02-19T00:00:002025-02-19T00:00:00Collagen25.314527621364437e-0022022-06-17T00:00:002022-12-14T00:00:00Fibroblasts25.279074502886508e-0022025-02-19T00:00:002025-03-19T00:00:00Bleomycin15.189993066740897e-0022025-03-19T00:00:002025-03-19T00:00:00Cell Differentiation15.122663052432805e-0022021-10-05T00:00:002021-10-05T00:00:00Reproducibility of Results14.951541146607572e-0022021-10-08T00:00:002021-10-08T00:00:00Vanadates14.874231856268022e-0022022-12-14T00:00:002022-12-14T00:00:00YAP-Signaling Proteins14.859982672743950e-0022025-02-19T00:00:002025-02-19T00:00:00Tensile Strength14.467300422413618e-0022022-12-14T00:00:002022-12-14T00:00:00Smog14.429104419811122e-0022021-05-07T00:00:002021-05-07T00:00:00Adrenergic Agents14.356879813849376e-0022021-10-01T00:00:002021-10-01T00:00:00Mouth Mucosa13.602155483141628e-0022021-10-12T00:00:002021-10-12T00:00:00Infant13.596694265967195e-0022021-06-02T00:00:002021-06-02T00:00:00Perfusion13.508065801519977e-0022024-04-01T00:00:002024-04-01T00:00:00Male43.358152597019450e-0022022-08-01T00:00:002025-03-19T00:00:00Stromal Cells13.278233101637810e-0022022-12-09T00:00:002022-12-09T00:00:00Keratinocytes13.234963163447979e-0022021-10-12T00:00:002021-10-12T00:00:00Extracellular Matrix13.196405288051404e-0022025-03-19T00:00:002025-03-19T00:00:00Microvessels13.183921084876466e-0022021-10-06T00:00:002021-10-06T00:00:00Atrophy13.067743832808881e-0022021-09-06T00:00:002021-09-06T00:00:00Skin Transplantation12.992309084069663e-0022021-10-01T00:00:002021-10-01T00:00:00Radiotherapy12.988523893097644e-0022022-12-09T00:00:002022-12-09T00:00:00Mice, Inbred C57BL22.882240929118517e-0022024-04-01T00:00:002025-03-19T00:00:00Swine12.882182774312168e-0022025-02-19T00:00:002025-02-19T00:00:00Comprehension12.828970138587602e-0022021-05-07T00:00:002021-05-07T00:00:00Disease Susceptibility12.780400093438522e-0022021-10-06T00:00:002021-10-06T00:00:00Antigens, CD12.698084027444560e-0022025-03-19T00:00:002025-03-19T00:00:00Treatment Outcome12.625221701055847e-0022021-06-02T00:00:002021-06-02T00:00:00Nitric Oxide12.494249850033661e-0022022-06-17T00:00:002022-06-17T00:00:00Reactive Oxygen Species12.477243373001627e-0022021-10-06T00:00:002021-10-06T00:00:00Surgical Flaps12.383314685948589e-0022021-10-01T00:00:002021-10-01T00:00:00Single-Cell Analysis12.310566949616679e-0022025-03-19T00:00:002025-03-19T00:00:00Retrospective Studies12.228007304762132e-0022021-06-02T00:00:002021-06-02T00:00:00Oxidative Stress12.013291799568331e-0022021-10-06T00:00:002021-10-06T00:00:00Adult21.928900791854466e-0022021-10-08T00:00:002021-10-12T00:00:00Internet11.802361829598680e-0022021-05-07T00:00:002021-05-07T00:00:00Membrane Proteins11.712105102005719e-0022025-03-19T00:00:002025-03-19T00:00:00Rats11.561816438068789e-0022022-12-14T00:00:002022-12-14T00:00:00Biomarkers19.502003237659736e-0032021-10-06T00:00:002021-10-06T00:00:00Female39.282807024281808e-0032021-10-05T00:00:002025-03-19T00:00:00Child15.909542418913233e-0032021-05-07T00:00:002021-05-07T00:00:00Middle Aged13.854763783390875e-0032021-10-05T00:00:002021-10-05T00:00:00Bardia Abbasi, M.D.BardiaAbbasi

Beth Israel Deaconess Medical CenterKirstein 4330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterNeurologyInstructor in NeurologyInstructor2HMSHarvard Medical SchoolPMEMBB Course Co-Director, PWY140, Fall 2025, 2026 and 2027Other Faculty3MEEIMassachusetts Eye and Ear InfirmaryOphthalmologyInstructor in OphthalmologyInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/41493597Perivascular Diffusivity Suggests Dynamic and Modifiable Glymphatic Transit in Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2026 Mar 01; 46(1):105-112.Bouffard MA, Comeau DS, Avanaki MA, Jaafar N, Brook A, Abbasi B, Alsop DC, Chang YM, Rizzo JF, Mallery RM, Chwalisz BK, Reinshagen KL, Grech O, Ford JN. J Neuroophthalmol2026 Mar 0146(1):105-112http://www.ncbi.nlm.nih.gov/pubmed/39228018MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2024 Sep 04; 45(3):321-326.Bouffard MA, Avanaki MA, Ford JN, Jaafar N, Brook A, Abbasi B, Torun N, Alsop D, Comeau DS, Chang YM. J Neuroophthalmol2024 Sep 0445(3):321-326http://www.ncbi.nlm.nih.gov/pubmed/38958939Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide. JAMA Ophthalmol. 2024 Aug 01; 142(8):732-739.Hathaway JT, Shah MP, Hathaway DB, Zekavat SM, Krasniqi D, Gittinger JW, Cestari D, Mallery R, Abbasi B, Bouffard M, Chwalisz BK, Estrela T, Rizzo JF. JAMA Ophthalmol2024 Aug 01142(8):732-739http://www.ncbi.nlm.nih.gov/pubmed/33734937Advances in Neuroscience, Not Devices, Will Determine the Effectiveness of Visual Prostheses. Semin Ophthalmol. 2021 May 19; 36(4):168-175.Abbasi B, Rizzo JF. Semin Ophthalmol2021 May 1936(4):168-175http://www.ncbi.nlm.nih.gov/pubmed/31478577Machine learning applications in epilepsy. Epilepsia. 2019 10; 60(10):2037-2047.Abbasi B, Goldenholz DM. Epilepsia2019 1060(10):2037-2047http://www.ncbi.nlm.nih.gov/pubmed/24753616Hypermutable DNA chronicles the evolution of human colon cancer. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):E1889-98.Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK. Proc Natl Acad Sci U S A2014 May 06111(18):E1889-98http://www.ncbi.nlm.nih.gov/pubmed/20376405Attenuated total reflection Fourier transform infrared spectroscopy for on-chip monitoring of solute concentrations. Lab Chip. 2010 Jun 21; 10(12):1561-6.Greener J, Abbasi B, Kumacheva E. Lab Chip2010 Jun 2110(12):1561-6Visual Prosthesis16.477124672726090e-0012021-03-18T00:00:002021-03-18T00:00:00Pseudotumor Cerebri23.996820272384045e-0012024-09-04T00:00:002026-01-07T00:00:00Glymphatic System23.953833195325293e-0012024-09-04T00:00:002026-01-07T00:00:00Seizures12.442350762859131e-0012019-09-03T00:00:002019-09-03T00:00:00Intracranial Pressure22.430890681276196e-0012024-09-04T00:00:002026-01-07T00:00:00Diffusion Tensor Imaging22.138204698717277e-0012024-09-04T00:00:002026-01-07T00:00:00Epilepsy12.064733871873415e-0012019-09-03T00:00:002019-09-03T00:00:00Machine Learning12.063724037447220e-0012019-09-03T00:00:002019-09-03T00:00:00Optic Neuropathy, Ischemic11.956270389391620e-0012024-08-01T00:00:002024-08-01T00:00:00Glucagon-Like Peptides11.767882990769622e-0012024-08-01T00:00:002024-08-01T00:00:00Vision, Ocular11.364452546925773e-0012021-03-18T00:00:002021-03-18T00:00:00Reading11.293984987235019e-0012021-03-18T00:00:002021-03-18T00:00:00Signal Processing, Computer-Assisted19.340246368703434e-0022019-09-03T00:00:002019-09-03T00:00:00Brain19.160805386492536e-0022019-09-03T00:00:002019-09-03T00:00:00Hypoglycemic Agents18.330832159102471e-0022024-08-01T00:00:002024-08-01T00:00:00Spectroscopy, Fourier Transform Infrared17.856083848725937e-0022010-04-08T00:00:002010-04-08T00:00:00Visual Acuity17.787053892594503e-0022021-03-18T00:00:002021-03-18T00:00:00DNA, Neoplasm17.347030391956150e-0022014-04-21T00:00:002014-04-21T00:00:00Deep Learning15.577760942879446e-0022019-09-03T00:00:002019-09-03T00:00:00Semaglutide15.179825182027081e-0022024-08-01T00:00:002024-08-01T00:00:00Microfluidic Analytical Techniques15.166711075112752e-0022010-04-08T00:00:002010-04-08T00:00:00Electroencephalography15.073761997928169e-0022019-09-03T00:00:002019-09-03T00:00:00Papilledema14.810144834467751e-0022024-09-04T00:00:002024-09-04T00:00:00Colonic Neoplasms14.571528759225737e-0022014-04-21T00:00:002014-04-21T00:00:00Diabetes Mellitus, Type 214.021022157819894e-0022024-08-01T00:00:002024-08-01T00:00:00Neurons13.879126263499169e-0022019-09-03T00:00:002019-09-03T00:00:00Quality of Life13.638337730851304e-0022021-03-18T00:00:002021-03-18T00:00:00Poly G12.708626824481079e-0022014-04-21T00:00:002014-04-21T00:00:00Humans62.307773077545450e-0022014-04-21T00:00:002026-01-07T00:00:00Microsatellite Repeats12.192062701133422e-0022014-04-21T00:00:002014-04-21T00:00:00Genetic Heterogeneity12.042366808695423e-0022014-04-21T00:00:002014-04-21T00:00:00Photochemical Processes11.968019169505477e-0022010-04-08T00:00:002010-04-08T00:00:00Adsorption11.940795617666798e-0022010-04-08T00:00:002010-04-08T00:00:00Surface-Active Agents11.920864329353424e-0022010-04-08T00:00:002010-04-08T00:00:00Mutation11.880440354287136e-0022014-04-21T00:00:002014-04-21T00:00:00Mitosis11.826744581241930e-0022014-04-21T00:00:002014-04-21T00:00:00Middle Aged41.688266369491588e-0022014-04-21T00:00:002026-01-07T00:00:00Carcinogenesis11.526379636325863e-0022014-04-21T00:00:002014-04-21T00:00:00Phylogeny11.479964079017931e-0022014-04-21T00:00:002014-04-21T00:00:00Incidence11.460352285305423e-0022024-08-01T00:00:002024-08-01T00:00:00Ultraviolet Rays11.371053997384861e-0022010-04-08T00:00:002010-04-08T00:00:00Cross-Sectional Studies11.308795038008664e-0022026-01-07T00:00:002026-01-07T00:00:00Adult31.219566300155765e-0022014-04-21T00:00:002026-01-07T00:00:00Polymers11.189390610537472e-0022010-04-08T00:00:002010-04-08T00:00:00Male31.134552225197212e-0022024-08-01T00:00:002026-01-07T00:00:00Female31.073826477444491e-0022024-08-01T00:00:002026-01-07T00:00:00Young Adult18.931417817482020e-0032026-01-07T00:00:002026-01-07T00:00:00Risk Factors18.001260427065669e-0032024-08-01T00:00:002024-08-01T00:00:00Aged27.805648783429758e-0032014-04-21T00:00:002024-08-01T00:00:00Adenocarcinoma17.779720509267653e-0032014-04-21T00:00:002014-04-21T00:00:00Cell Differentiation17.637135077939071e-0032014-04-21T00:00:002014-04-21T00:00:00Retrospective Studies16.936354382501367e-0032024-08-01T00:00:002024-08-01T00:00:00Cohort Studies15.373138016405838e-0032014-04-21T00:00:002014-04-21T00:00:00Aged, 80 and over14.378612851247694e-0032014-04-21T00:00:002014-04-21T00:00:00Time Factors14.374904294178737e-0032010-04-08T00:00:002010-04-08T00:00:00Bassima Abdallah, M.D.BassimaAbdallah

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617 754 4677

1BIDMCBeth Israel Deaconess Medical CenterMedicineGeneral MedicineInstructor in MedicineInstructorAdham Abdel Mottalib, M.D.AdhamAbdel Mottalib

Joslin Diabetes Center One Joslin PlaceBoston, MA 02215617 3092440

1BIDMCBeth Israel Deaconess Medical CenterMedicineEndocrinologyInstructor in MedicineInstructorhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=1257798http://www.ncbi.nlm.nih.gov/pubmed/29626933Effects of nutrition therapy on HbA1c and cardiovascular disease risk factors in overweight and obese patients with type 2 diabetes. Nutr J. 2018 04 07; 17(1):42.Mottalib A, Salsberg V, Mohd-Yusof BN, Mohamed W, Carolan P, Pober DM, Mitri J, Hamdy O. Nutr J2018 04 0717(1):42http://www.ncbi.nlm.nih.gov/pubmed/29657719Inpatient diabetes management by specialized diabetes team versus primary service team in non-critical care units: impact on 30-day readmission rate and hospital cost. BMJ Open Diabetes Res Care. 2018; 6(1):e000460.Bansal V, Mottalib A, Pawar TK, Abbasakoor N, Chuang E, Chaudhry A, Sakr M, Gabbay RA, Hamdy O. BMJ Open Diabetes Res Care20186(1):e000460http://www.ncbi.nlm.nih.gov/pubmed/28836234Weight Management in Patients with Type 1 Diabetes and Obesity. Curr Diab Rep. 2017 08 23; 17(10):92.Mottalib A, Kasetty M, Mar JY, Elseaidy T, Ashrafzadeh S, Hamdy O. Curr Diab Rep2017 08 2317(10):92http://www.ncbi.nlm.nih.gov/pubmed/28090332Long-term effect of intensive lifestyle intervention on cardiovascular risk factors in patients with diabetes in real-world clinical practice: a 5-year longitudinal study. BMJ Open Diabetes Res Care. 2017; 5(1):e000259.Hamdy O, Mottalib A, Morsi A, El-Sayed N, Goebel-Fabbri A, Arathuzik G, Shahar J, Kirpitch A, Zrebiec J. BMJ Open Diabetes Res Care20175(1):e000259http://www.ncbi.nlm.nih.gov/pubmed/27455318Impact of Diabetes-Specific Nutritional Formulas versus Oatmeal on Postprandial Glucose, Insulin, GLP-1 and Postprandial Lipidemia. Nutrients. 2016 Jul 22; 8(7).Mottalib A, Mohd-Yusof BN, Shehabeldin M, Pober DM, Mitri J, Hamdy O. Nutrients2016 Jul 228(7)http://www.ncbi.nlm.nih.gov/pubmed/26797024Unifocal versus multifocal mandibular fractures and injury location. Emerg Radiol. 2016 Apr; 23(2):161-7.Buch K, Mottalib A, Nadgir RN, Fujita A, Sekiya K, Ozonoff A, Sakai O. Emerg Radiol2016 Apr23(2):161-7http://www.ncbi.nlm.nih.gov/pubmed/26114120Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes. J Diabetes Res. 2015; 2015:468704.Mottalib A, Sakr M, Shehabeldin M, Hamdy O. J Diabetes Res20152015:468704Hyperglycemia22.594703229139868e-0012015-05-31T00:00:002016-07-22T00:00:00Nutrition Therapy12.502384929762193e-0012018-04-07T00:00:002018-04-07T00:00:00Food, Formulated12.370238174284874e-0012016-07-22T00:00:002016-07-22T00:00:00Overweight22.361421078049467e-0012016-07-22T00:00:002018-04-07T00:00:00Mandibular Fractures12.243979287624115e-0012016-01-21T00:00:002016-01-21T00:00:00Glycated Hemoglobin32.028340467662210e-0012015-05-31T00:00:002018-04-07T00:00:00Hyperinsulinism11.986040245358560e-0012016-07-22T00:00:002016-07-22T00:00:00Hyperlipidemias11.747838421740284e-0012016-07-22T00:00:002016-07-22T00:00:00Diet, Reducing31.480868846885759e-0012015-05-31T00:00:002018-04-07T00:00:00Diabetes Mellitus, Type 231.405854792825079e-0012015-05-31T00:00:002018-04-07T00:00:00Obesity31.325966120794236e-0012015-05-31T00:00:002018-04-07T00:00:00Life Style21.298991601272858e-0012015-05-31T00:00:002018-04-07T00:00:00Meals21.053107428808354e-0012016-07-22T00:00:002018-04-07T00:00:00Precision Medicine18.646847657401729e-0022015-05-31T00:00:002015-05-31T00:00:00Weight Loss28.343410468005669e-0022015-05-31T00:00:002017-08-23T00:00:00Nutritionists16.839483239516177e-0022018-04-07T00:00:002018-04-07T00:00:00Avena16.301570991654286e-0022016-07-22T00:00:002016-07-22T00:00:00Diet, Diabetic16.149551187444777e-0022016-07-22T00:00:002016-07-22T00:00:00Seeds15.946451177952799e-0022016-07-22T00:00:002016-07-22T00:00:00Dietary Fats, Unsaturated15.611353867626198e-0022016-07-22T00:00:002016-07-22T00:00:00Body Mass Index35.450508905463012e-0022015-05-31T00:00:002018-04-07T00:00:00Waist Circumference15.245856152125871e-0022018-04-07T00:00:002018-04-07T00:00:00Glycemic Index15.187516584856701e-0022016-07-22T00:00:002016-07-22T00:00:00Glucagon-Like Peptide 115.030814285678000e-0022016-07-22T00:00:002016-07-22T00:00:00Diabetes Mellitus, Type 114.656338334392718e-0022017-08-23T00:00:002017-08-23T00:00:00Tomography, X-Ray Computed14.617550055480006e-0022016-01-21T00:00:002016-01-21T00:00:00Cardiovascular Diseases14.525786422472329e-0022018-04-07T00:00:002018-04-07T00:00:00Behavior Therapy14.421851685533192e-0022018-04-07T00:00:002018-04-07T00:00:00Dietary Carbohydrates14.406658481453653e-0022016-07-22T00:00:002016-07-22T00:00:00Cross-Over Studies13.924996192965084e-0022016-07-22T00:00:002016-07-22T00:00:00Counseling13.849929042474017e-0022018-04-07T00:00:002018-04-07T00:00:00Remission Induction13.782705369365738e-0022015-05-31T00:00:002015-05-31T00:00:00Body Composition13.585862823796252e-0022018-04-07T00:00:002018-04-07T00:00:00Drug Monitoring12.912537809992738e-0022015-05-31T00:00:002015-05-31T00:00:00Drug Therapy, Combination12.828267370143053e-0022015-05-31T00:00:002015-05-31T00:00:00Patient Education as Topic12.701031484354977e-0022015-05-31T00:00:002015-05-31T00:00:00Combined Modality Therapy12.492383489953017e-0022015-05-31T00:00:002015-05-31T00:00:00Cognitive Behavioral Therapy12.394960721255802e-0022015-05-31T00:00:002015-05-31T00:00:00Boston12.323778067719954e-0022015-05-31T00:00:002015-05-31T00:00:00Hypoglycemic Agents12.205767297573506e-0022015-05-31T00:00:002015-05-31T00:00:00Middle Aged42.158104447744802e-0022015-05-31T00:00:002018-04-07T00:00:00Aged31.856428241346902e-0022016-01-21T00:00:002018-04-07T00:00:00Exercise11.724592390807066e-0022015-05-31T00:00:002015-05-31T00:00:00Weight Gain11.630155628284728e-0022017-08-23T00:00:002017-08-23T00:00:00Bariatric Surgery11.599597790097747e-0022017-08-23T00:00:002017-08-23T00:00:00Retrospective Studies21.502742566381993e-0022015-05-31T00:00:002016-01-21T00:00:00Male31.292657460604022e-0022016-01-21T00:00:002018-04-07T00:00:00Follow-Up Studies11.261088952820052e-0022015-05-31T00:00:002015-05-31T00:00:00Humans51.253544591146383e-0022015-05-31T00:00:002018-04-07T00:00:00Infant11.239988345003638e-0022016-01-21T00:00:002016-01-21T00:00:00Female31.223469291791725e-0022016-01-21T00:00:002018-04-07T00:00:00Insulin11.216788799381662e-0022017-08-23T00:00:002017-08-23T00:00:00Child, Preschool11.172684254429833e-0022016-01-21T00:00:002016-01-21T00:00:00Treatment Outcome11.054850725029301e-0022018-04-07T00:00:002018-04-07T00:00:00Risk Factors11.032687126736000e-0022018-04-07T00:00:002018-04-07T00:00:00Aged, 80 and over19.888120643171837e-0032016-01-21T00:00:002016-01-21T00:00:00Young Adult18.954328912602177e-0032016-01-21T00:00:002016-01-21T00:00:00Child18.189752585966078e-0032016-01-21T00:00:002016-01-21T00:00:00Adolescent18.070874065158841e-0032016-01-21T00:00:002016-01-21T00:00:00Adult15.191568183744223e-0032016-01-21T00:00:002016-01-21T00:00:00Houda Abdelrahman, M.D.HoudaAbdelrahman

Beth Israel Deaconess Medical CenterDivision: Endocrinology330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineEndocrinologyClinical Fellow in MedicineFellow or Post DocKhaled Abdelrahman, M.D.KhaledAbdelrahman

Beth Israel Deaconess Medical Center185 Pilgrim Street, Baker 4th Floor330 Brookline AveBoston, MA 02215913/644-9738

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41141611The association of coronary artery disease by coronary CT angiography & cardiovascular outcomes in Psoriatic disease. Am J Prev Cardiol. 2025 Dec; 24:101317.Aun JA, Huck DM, Besser SA, Shiyovich A, Petranovic M, Berman AN, Blair CV, Kotanidis CP, Hainer J, Biery DW, Trivedi N, Abdelrahman K, Cardoso R, Merola J, Garshick M, Ghoshhajra B, Hegdire S, Carli MD, Blankstein R, Weber BN. Am J Prev Cardiol2025 Dec24:101317http://www.ncbi.nlm.nih.gov/pubmed/40398639Sequencing and genome-scale virulome reconstruction of Enterococcus faecalis clinical isolates delineate genes involved in gelatinase activity and biofilm formation. Microb Pathog. 2025 Sep; 206:107721.Abdelrahman KA, Hashem YA, Szubin R, Monk JM, Kashef MT, Aziz RK. Microb Pathog2025 Sep206:107721http://www.ncbi.nlm.nih.gov/pubmed/38646022Lipoprotein(a): Emerging insights and therapeutics. Am J Prev Cardiol. 2024 Jun; 18:100641.Kaur G, Abdelrahman K, Berman AN, Biery DW, Shiyovich A, Huck D, Garshick M, Blankstein R, Weber B. Am J Prev Cardiol2024 Jun18:100641http://www.ncbi.nlm.nih.gov/pubmed/38628335Malignant peripheral nerve sheath tumor of the femoral nerve: imaging findings and correlation with histopathology. Proc (Bayl Univ Med Cent). 2024; 37(3):485-488.Kumar P, Abdelrahman K, Maheshwari S, Dey AK. Proc (Bayl Univ Med Cent)202437(3):485-488http://www.ncbi.nlm.nih.gov/pubmed/38248002Artificial Intelligence in Coronary Artery Calcium Scoring Detection and Quantification. Diagnostics (Basel). 2024 Jan 05; 14(2).Abdelrahman K, Shiyovich A, Huck DM, Berman AN, Weber B, Gupta S, Cardoso R, Blankstein R. Diagnostics (Basel)2024 Jan 0514(2)http://www.ncbi.nlm.nih.gov/pubmed/35389891Complex association of apolipoprotein E-containing HDL with coronary artery disease burden in cardiovascular disease. JCI Insight. 2022 05 23; 7(10).Sorokin AV, Patel N, Abdelrahman KM, Ling C, Reimund M, Graziano G, Sampson M, Playford MP, Dey AK, Reddy A, Teague HL, Stagliano M, Amar M, Chen MY, Mehta NN, Remaley AT. JCI Insight2022 05 237(10)http://www.ncbi.nlm.nih.gov/pubmed/35366378Inflammation, coronary plaque progression, and statin use: A secondary analysis of the Risk Stratification with Image Guidance of HMG CoA Reductase Inhibitor Therapy (RIGHT) study. Clin Cardiol. 2022 Jun; 45(6):622-628.Scott C, Lateef SS, Hong CG, Dey AK, Manyak GA, Patel NH, Zhou W, Sorokin AV, Abdelrahman K, Uceda D, Teklu M, Wu C, Parel PM, Sandfort V, Chen MY, Mallek M, Ahlman M, Bluemke D, Mehta NN. Clin Cardiol2022 Jun45(6):622-628http://www.ncbi.nlm.nih.gov/pubmed/34147437Sex Differences in Subclinical Coronary Atherosclerosis in Psoriasis by Coronary Computed Tomography Angiography. JACC Cardiovasc Imaging. 2021 10; 14(10):2044-2046.Teklu M, Zhou W, Kapoor P, Patel N, Playford MP, Sorokin AV, Dey AK, Teague HL, Abdelrahman KM, Manyak GA, Erb-Alvarez JA, Shanbhag SM, Rodante JA, Keel A, Lockshin B, Chen MY, Gelfand JM, Bluemke DA, Wenger NK, Mehta NN. JACC Cardiovasc Imaging2021 1014(10):2044-2046http://www.ncbi.nlm.nih.gov/pubmed/34199290Nutritional Supplements for the Treatment of Neuropathic Pain. Biomedicines. 2021 Jun 13; 9(6).Abdelrahman KM, Hackshaw KV. Biomedicines2021 Jun 139(6)http://www.ncbi.nlm.nih.gov/pubmed/33383084Metabolic syndrome and its factors are associated with noncalcified coronary burden in psoriasis: An observational cohort study. J Am Acad Dermatol. 2021 May; 84(5):1329-1338.Teklu M, Zhou W, Kapoor P, Patel N, Dey AK, Sorokin AV, Manyak GA, Teague HL, Erb-Alvarez JA, Sajja A, Abdelrahman KM, Reddy AS, Uceda DE, Lateef SS, Shanbhag SM, Scott C, Prakash N, Svirydava M, Parel P, Rodante JA, Keel A, Siegel EL, Chen MY, Bluemke DA, Playford MP, Gelfand JM, Mehta NN. J Am Acad Dermatol2021 May84(5):1329-1338http://www.ncbi.nlm.nih.gov/pubmed/33104056Chronic inflammation in psoriasis promotes visceral adiposity associated with noncalcified coronary burden over time. JCI Insight. 2020 11 19; 5(22).Sajja A, Abdelrahman KM, Reddy AS, Dey AK, Uceda DE, Lateef SS, Sorokin AV, Teague HL, Chung J, Rivers J, Joshi AA, Elnabawi YA, Goyal A, Rodante JA, Keel A, Alvarez JE, Lockshin B, Prussick R, Siegel E, Playford MP, Chen MY, Bluemke DA, Gelfand JM, Mehta NN. JCI Insight2020 11 195(22)http://www.ncbi.nlm.nih.gov/pubmed/33170072Association Among Noncalcified Coronary Burden, Fractional Flow Reserve, and Myocardial Injury in Psoriasis. J Am Heart Assoc. 2020 11 17; 9(22):e017417.Zhou W, Abdelrahman KM, Dey AK, Reddy A, Uceda DE, Lateef SS, Elnabawi YA, Anzenberg P, Al Najafi M, Rodante JA, Keel A, Ortiz J, Teague HL, Erb-Alvarez J, Singh D, Joshi AA, Playford MP, Chen MY, Gelfand JM, Remaley AT, Bluemke DA, Mehta NN. J Am Heart Assoc2020 11 179(22):e017417http://www.ncbi.nlm.nih.gov/pubmed/33011154Impaired Coronary Blood Flow in Patients with Psoriasis: Findings from an Observational Cohort Study. J Invest Dermatol. 2021 04; 141(4):913-916.Uceda DE, Dey AK, Lateef SS, Abdelrahman K, Aksentijevich M, Reddy AS, Choi H, Rodante JA, Playford MP, Bluemke DA, Zhou W, Chen MY, Gelfand JM, Mehta NN. J Invest Dermatol2021 04141(4):913-916http://www.ncbi.nlm.nih.gov/pubmed/33500761Total Radial Artery Occlusion Following Transradial Access: Complete Recanalization via the Anatomical Snuffbox. Methodist Debakey Cardiovasc J. 2020 Oct-Dec; 16(4):314-317.Ali S, Abdullah MS, Abdelrahman K, Ali A, Faisal F, Ali A. Methodist Debakey Cardiovasc J2020 Oct-Dec16(4):314-317http://www.ncbi.nlm.nih.gov/pubmed/32927971Treatment of Psoriasis With Biologic Therapy Is Associated With Improvement of Coronary Artery Plaque Lipid-Rich Necrotic Core: Results From a Prospective, Observational Study. Circ Cardiovasc Imaging. 2020 09; 13(9):e011199.Choi H, Uceda DE, Dey AK, Abdelrahman KM, Aksentijevich M, Rodante JA, Elnabawi YA, Reddy A, Keel A, Erb-Alvarez J, Teague H, Playford MP, Zhou W, Chen MY, Gelfand JM, Bluemke DA, Buckler A, Mehta NN. Circ Cardiovasc Imaging2020 0913(9):e011199http://www.ncbi.nlm.nih.gov/pubmed/32883417Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 09 08; 76(10):1226-1243.Abdelrahman KM, Chen MY, Dey AK, Virmani R, Finn AV, Khamis RY, Choi AD, Min JK, Williams MC, Buckler AJ, Taylor CA, Rogers C, Samady H, Antoniades C, Shaw LJ, Budoff MJ, Hoffmann U, Blankstein R, Narula J, Mehta NN. J Am Coll Cardiol2020 09 0876(10):1226-1243http://www.ncbi.nlm.nih.gov/pubmed/32882485Relationship between chronic stress-related neural activity, physiological dysregulation and coronary artery disease in psoriasis: Findings from a longitudinal observational cohort study. Atherosclerosis. 2020 10; 310:37-44.Lateef SS, Al Najafi M, Dey AK, Batool M, Abdelrahman KM, Uceda DE, Reddy AS, Svirydava MD, Nanda N, Ortiz JE, Prakash N, Rodante JA, Keel A, Zhou W, Chen MY, Playford MP, Teague HL, Tawakol AA, Gelfand JM, Powell-Wiley TM, Mehta NN. Atherosclerosis2020 10310:37-44http://www.ncbi.nlm.nih.gov/pubmed/32427522Juvenile dermatomyositis presenting as complete heart block in a 10-year-old girl. Paediatr Int Child Health. 2020 11; 40(4):251-254.Ghosh R, Roy D, Dubey S, Abdelrahman K, Dey AK, Chatterjee S, Lahiri D, Ray BK. Paediatr Int Child Health2020 1140(4):251-254http://www.ncbi.nlm.nih.gov/pubmed/32280420Williams-Beuren Syndrome: The Role of Cardiac CT in Diagnosis. Methodist Debakey Cardiovasc J. 2020 Jan-Mar; 16(1):61-64.Kumar P, Abdelrahman K, Das B, Tp S, Dey AK. Methodist Debakey Cardiovasc J2020 Jan-Mar16(1):61-64http://www.ncbi.nlm.nih.gov/pubmed/31713294Optimizing Delivery of Breast Milk for Premature Infants: Comparison of Current Enteral Feeding Systems. Nutr Clin Pract. 2020 Aug; 35(4):697-702.Abdelrahman K, Jarjour J, Hagan J, Yang H, Sutton D, Hair A. Nutr Clin Pract2020 Aug35(4):697-702http://www.ncbi.nlm.nih.gov/pubmed/30165189Development and characterization of ORF68 negative equine herpes virus type-1, Ab4p strain. J Virol Methods. 2018 11; 261:121-131.Ata EB, Zaghawa A, Ghazy AA, Elsify A, Abdelrahman K, Kasem S, Nayel M. J Virol Methods2018 11261:121-131http://www.ncbi.nlm.nih.gov/pubmed/25679230Fortifier and cream improve fat delivery in continuous enteral infant feeding of breast milk. Nutrients. 2015 Feb 11; 7(2):1174-83.Tabata M, Abdelrahman K, Hair AB, Hawthorne KM, Chen Z, Abrams SA. Nutrients2015 Feb 117(2):1174-83Gelatinases18.916138846341417e-0012025-05-20T00:00:002025-05-20T00:00:00Enterococcus faecalis18.141391106869383e-0012025-05-20T00:00:002025-05-20T00:00:00Psoriasis76.666320579700804e-0012020-07-29T00:00:002021-06-16T00:00:00Biofilms16.234554856885621e-0012025-05-20T00:00:002025-05-20T00:00:00Syringes16.083681310354333e-0012019-11-11T00:00:002019-11-11T00:00:00Genome, Bacterial16.078683221446027e-0012025-05-20T00:00:002025-05-20T00:00:00Biomedical Technology15.612979261547412e-0012020-09-08T00:00:002020-09-08T00:00:00Coronary Artery Disease105.536632543997802e-0012020-07-29T00:00:002022-05-23T00:00:00Computed Tomography Angiography85.381365559543189e-0012020-01-01T00:00:002021-06-16T00:00:00Milk, Human25.199726404235869e-0012015-02-11T00:00:002019-11-11T00:00:00Enteral Nutrition24.699721138959018e-0012015-02-11T00:00:002019-11-11T00:00:00Coronary Angiography64.377188982447707e-0012020-01-01T00:00:002021-06-16T00:00:00Dietary Fats13.635895312909734e-0012019-11-11T00:00:002019-11-11T00:00:00Equipment Design13.452013635868031e-0012019-11-11T00:00:002019-11-11T00:00:00Plaque, Atherosclerotic32.375845466552683e-0012020-09-15T00:00:002022-05-23T00:00:00Prophages12.254064178011139e-0012025-05-20T00:00:002025-05-20T00:00:00Gram-Positive Bacterial Infections11.889844517033184e-0012025-05-20T00:00:002025-05-20T00:00:00Genes, Bacterial11.759439426437991e-0012025-05-20T00:00:002025-05-20T00:00:00Virulence Factors11.753321351223783e-0012025-05-20T00:00:002025-05-20T00:00:00Atherectomy11.643780033104432e-0012020-10-01T00:00:002020-10-01T00:00:00Polyurethanes11.480622553439249e-0012019-11-11T00:00:002019-11-11T00:00:00Herpesvirus 1, Equid11.472333336200730e-0012018-08-27T00:00:002018-08-27T00:00:00Silicones11.440830681567638e-0012019-11-11T00:00:002019-11-11T00:00:00Review Literature as Topic11.423996115120893e-0012020-09-08T00:00:002020-09-08T00:00:00Radial Artery11.407444519851602e-0012020-10-01T00:00:002020-10-01T00:00:00Whole Genome Sequencing11.395424943758586e-0012025-05-20T00:00:002025-05-20T00:00:00Heart Block11.392644898104345e-0012020-05-19T00:00:002020-05-19T00:00:00Heart Valves11.387124984985236e-0012020-01-01T00:00:002020-01-01T00:00:00Intensive Care, Neonatal11.360383705525042e-0012019-11-11T00:00:002019-11-11T00:00:00Aortography11.353722624381265e-0012020-01-01T00:00:002020-01-01T00:00:00Williams Syndrome11.330956836338218e-0012020-01-01T00:00:002020-01-01T00:00:00Infant, Premature21.324828761923462e-0012015-02-11T00:00:002019-11-11T00:00:00Catheterization, Peripheral11.264472594008896e-0012020-10-01T00:00:002020-10-01T00:00:00Dermatomyositis11.251976193901765e-0012020-05-19T00:00:002020-05-19T00:00:00Fractional Flow Reserve, Myocardial11.249482362510455e-0012020-11-10T00:00:002020-11-10T00:00:00Arterial Occlusive Diseases11.224898773776144e-0012020-10-01T00:00:002020-10-01T00:00:00Angioplasty, Balloon11.219095354095572e-0012020-10-01T00:00:002020-10-01T00:00:00Intra-Abdominal Fat11.150453235097100e-0012020-11-19T00:00:002020-11-19T00:00:00Multidetector Computed Tomography11.123273355612450e-0012020-01-01T00:00:002020-01-01T00:00:00Food, Fortified11.021988480907102e-0012015-02-11T00:00:002015-02-11T00:00:00Chest Pain11.014785158564543e-0012020-09-08T00:00:002020-09-08T00:00:00Vascular Calcification11.007260788091321e-0012020-09-08T00:00:002020-09-08T00:00:00Calcinosis19.919937375781547e-0022022-04-02T00:00:002022-04-02T00:00:00Intensive Care Units, Neonatal18.962822035429399e-0022019-11-11T00:00:002019-11-11T00:00:00Bacterial Proteins18.914446760913852e-0022025-05-20T00:00:002025-05-20T00:00:00Infant, Very Low Birth Weight18.902455317043249e-0022015-02-11T00:00:002015-02-11T00:00:00Viral Proteins18.452073462055609e-0022018-08-27T00:00:002018-08-27T00:00:00Genotype18.368098887660239e-0022025-05-20T00:00:002025-05-20T00:00:00Biological Products18.319377905259678e-0022020-09-15T00:00:002020-09-15T00:00:00Metabolic Syndrome17.782475137995101e-0022021-02-03T00:00:002021-02-03T00:00:00Cardiometabolic Risk Factors26.840028975441356e-0022020-09-15T00:00:002021-02-03T00:00:00Hydroxymethylglutaryl-CoA Reductase Inhibitors16.483014427555513e-0022022-04-02T00:00:002022-04-02T00:00:00Thrombosis16.177434224477604e-0022020-10-01T00:00:002020-10-01T00:00:00Risk Assessment35.614872879223665e-0022020-09-08T00:00:002022-04-02T00:00:00Prospective Studies75.323459651289786e-0022020-07-29T00:00:002022-05-23T00:00:00Inflammation25.122502677267127e-0022020-11-19T00:00:002022-04-02T00:00:00Humans164.815597161120576e-0022015-02-11T00:00:002025-05-20T00:00:00Infant, Newborn24.399666722729356e-0022015-02-11T00:00:002019-11-11T00:00:00Apolipoprotein C-III14.125742790793333e-0022022-05-23T00:00:002022-05-23T00:00:00Longitudinal Studies33.836751731391453e-0022020-10-01T00:00:002021-02-03T00:00:00Punctures13.677200277581406e-0022020-10-01T00:00:002020-10-01T00:00:00Viral Plaque Assay13.614959765708711e-0022018-08-27T00:00:002018-08-27T00:00:00Female113.601257248161595e-0022015-02-11T00:00:002022-05-23T00:00:00Biomarkers13.576178115103712e-0022020-11-19T00:00:002020-11-19T00:00:00Chromosomes, Artificial, Bacterial13.549666971086078e-0022018-08-27T00:00:002018-08-27T00:00:00Lipoproteins, HDL13.431769286418461e-0022022-05-23T00:00:002022-05-23T00:00:00Horses13.341337783906286e-0022018-08-27T00:00:002018-08-27T00:00:00Nuclear Envelope13.288697102471435e-0022018-08-27T00:00:002018-08-27T00:00:00Vascular Patency13.196356503134673e-0022020-10-01T00:00:002020-10-01T00:00:00Waist Circumference13.190977053100859e-0022021-02-03T00:00:002021-02-03T00:00:00Apolipoproteins E13.044265533296386e-0022022-05-23T00:00:002022-05-23T00:00:00Male113.025912746281951e-0022015-02-11T00:00:002022-05-23T00:00:00Necrosis13.024307588411822e-0022020-09-15T00:00:002020-09-15T00:00:00Cardiovascular Diseases13.012085280406318e-0022022-05-23T00:00:002022-05-23T00:00:00Middle Aged82.927813927762252e-0022020-07-29T00:00:002022-05-23T00:00:00Troponin T12.921995887250302e-0022020-11-10T00:00:002020-11-10T00:00:00Heart Disease Risk Factors12.815846613010333e-0022020-10-01T00:00:002020-10-01T00:00:00Genes, Reporter12.726076469521456e-0022018-08-27T00:00:002018-08-27T00:00:00Sequence Deletion12.662615326365894e-0022018-08-27T00:00:002018-08-27T00:00:00Predictive Value of Tests22.600861806596330e-0022020-01-01T00:00:002021-06-16T00:00:00Nutritional Requirements12.488014237389748e-0022015-02-11T00:00:002015-02-11T00:00:00Prevalence22.467529104498349e-0022020-10-01T00:00:002020-11-10T00:00:00Green Fluorescent Proteins12.461784130556263e-0022018-08-27T00:00:002018-08-27T00:00:00Triglycerides12.450507582644296e-0022021-02-03T00:00:002021-02-03T00:00:00Cholesterol12.419386288029852e-0022022-05-23T00:00:002022-05-23T00:00:00Severity of Illness Index22.345570996468224e-0022020-09-15T00:00:002020-10-01T00:00:00Infant Nutritional Physiological Phenomena12.291152134042066e-0022015-02-11T00:00:002015-02-11T00:00:00Micronutrients12.183040659783779e-0022015-02-11T00:00:002015-02-11T00:00:00Microscopy, Fluorescence12.172213801221004e-0022018-08-27T00:00:002018-08-27T00:00:00Sex Characteristics12.045689288519094e-0022021-06-16T00:00:002021-06-16T00:00:00C-Reactive Protein11.997689083779211e-0022022-04-02T00:00:002022-04-02T00:00:00Recombinant Fusion Proteins11.926777184126337e-0022018-08-27T00:00:002018-08-27T00:00:00Cell Nucleus11.906096022769898e-0022018-08-27T00:00:002018-08-27T00:00:00Lipids11.885018812801800e-0022020-09-15T00:00:002020-09-15T00:00:00Viral Load11.862671808277789e-0022018-08-27T00:00:002018-08-27T00:00:00Cross-Sectional Studies21.838704620626387e-0022020-10-01T00:00:002021-02-03T00:00:00Electrocardiography11.572237435777046e-0022020-05-19T00:00:002020-05-19T00:00:00Escherichia coli11.529064682537286e-0022018-08-27T00:00:002018-08-27T00:00:00Adult41.447998270105235e-0022020-09-15T00:00:002021-02-03T00:00:00Infant21.395800611594314e-0022015-02-11T00:00:002020-01-01T00:00:00Blood Pressure11.371672328730106e-0022021-02-03T00:00:002021-02-03T00:00:00Disease Progression11.369102474209664e-0022022-04-02T00:00:002022-04-02T00:00:00Weight Gain11.367965921021998e-0022015-02-11T00:00:002015-02-11T00:00:00Cell Line11.365304849389516e-0022018-08-27T00:00:002018-08-27T00:00:00Diagnosis, Differential11.358222842724008e-0022020-01-01T00:00:002020-01-01T00:00:00Risk Factors21.263398497686221e-0022020-11-19T00:00:002021-06-16T00:00:00Treatment Outcome21.251316799391592e-0022020-09-15T00:00:002020-10-01T00:00:00Time Factors19.020415957685143e-0032020-09-15T00:00:002020-09-15T00:00:00Cohort Studies18.299396950882951e-0032020-07-29T00:00:002020-07-29T00:00:00Tomography, X-Ray Computed18.184079958066132e-0032021-02-03T00:00:002021-02-03T00:00:00Child15.526631008956365e-0032020-05-19T00:00:002020-05-19T00:00:00Animals13.786455821847813e-0032018-08-27T00:00:002018-08-27T00:00:00Youssef Abdullah, M.D.YoussefAbdullah

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineEndocrinologyClinical Fellow in MedicineFellow or Post DocNajma Abdullahi, M.D.NajmaAbdullahi

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterObstetrics Gynecology & Repro. Bio.Clinical Fellow in Obstetrics, Gynecology and Reproductive BiologyFellow or Post DocGyorgy Abel, M.D., Ph.D.GyorgyAbel

Beth Israel Deaconess Medical CenterDana Bldg., Room RW-0763C330 Brookline AveBoston, MA 02215781/744-895142.48558100000000-71.21425510000000

1BIDMCBeth Israel Deaconess Medical CenterPathologyInstructor in PathologyInstructorhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=1244220@GyorgyAbelMDhttp://www.ncbi.nlm.nih.gov/pubmed/39892879Historical Perspective on Antinuclear Antibody Testing. J Rheumatol. 2025 May 01; 52(5):412-419.Abel G, Ansari MQ, Snyder MR, Tebo AE, Wener MH, Naides SJ. J Rheumatol2025 May 0152(5):412-419http://www.ncbi.nlm.nih.gov/pubmed/38114235Expert guidance on target product profile development for AMR diagnostic tests. BMJ Glob Health. 2023 12 18; 8(12).Bachmann TT, Mitsakakis K, Hays JP, van Belkum A, Russom A, Luedke G, Simonsen GS, Abel G, Peter H, Goossens H, Moran-Gilad J, Vila J, Becker K, Moons P, Sampath R, Peeling RW, Luz S, van Staa T, Di Gregori V. BMJ Glob Health2023 12 188(12)http://www.ncbi.nlm.nih.gov/pubmed/34562617Two-Stage Hierarchical Group Testing Strategy to Increase SARS-CoV-2 Testing Capacity at an Institution of Higher Education: A Retrospective Analysis. J Mol Diagn. 2021 12; 23(12):1691-1698.Ganz TJ, Donner R, Hines KM, Waithe-Alleyne ML, Slate DL, Abel G, Auclair JR. J Mol Diagn2021 1223(12):1691-1698http://www.ncbi.nlm.nih.gov/pubmed/32525522Comparison of Tissue Molecular Biomarker Testing Turnaround Times and Concordance Between Standard of Care and the Biocartis Idylla Platform in Patients With Colorectal Cancer. Am J Clin Pathol. 2020 07 07; 154(2):266-276.Tsongalis GJ, Al Turkmani MR, Suriawinata M, Babcock MJ, Mitchell K, Ding Y, Scicchitano L, Tira A, Buckingham L, Atkinson S, Lax A, Aisner DL, Davies KD, Wood HN, O'Neill SS, Levine EA, Sequeira J, Harada S, DeFrank G, Paluri R, Tan BA, Colabella H, Snead C, Cruz-Correa M, Ramirez V, Rojas A, Huang H, Mackinnon AC, Garcia FU, Cavone SM, Elfahal M, Abel G, Vasef MA, Judd A, Linder MW, Alkhateeb K, Skinner WL, Boccia R, Patel K. Am J Clin Pathol2020 07 07154(2):266-276http://www.ncbi.nlm.nih.gov/pubmed/32445350The Need for New Weapons in the Fight Against Drug-Resistant Tuberculosis. J Appl Lab Med. 2020 05 01; 5(3):433-435.Abel G. J Appl Lab Med2020 05 015(3):433-435http://www.ncbi.nlm.nih.gov/pubmed/32173652Antinuclear Antibodies Testing Method Variability: A Survey of Participants in the College of American Pathologists' Proficiency Testing Program. J Rheumatol. 2020 12 01; 47(12):1768-1773.Naides SJ, Genzen JR, Abel G, Bashleben C, Ansari MQ. J Rheumatol2020 12 0147(12):1768-1773http://www.ncbi.nlm.nih.gov/pubmed/29266967Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice. Arch Pathol Lab Med. 2018 Apr; 142(4):507-515.Genzen JR, Murray DL, Abel G, Meng QH, Baltaro RJ, Rhoads DD, Delgado JC, Souers RJ, Bashleben C, Keren DF, Ansari MQ. Arch Pathol Lab Med2018 Apr142(4):507-515http://www.ncbi.nlm.nih.gov/pubmed/26109315Current status and future prospects of point-of-care testing around the globe. Expert Rev Mol Diagn. 2015; 15(7):853-5.Abel G. Expert Rev Mol Diagn201515(7):853-5http://www.ncbi.nlm.nih.gov/pubmed/24917564Impaired endothelial function in patients with undifferentiated connective tissue disease: a follow-up study. Rheumatology (Oxford). 2014 Nov; 53(11):2035-43.Laczik R, Soltesz P, Szodoray P, Szekanecz Z, Kerekes G, Paragh G, Rajnavölgyi E, Abel G, Szegedi G, Bodolay E. Rheumatology (Oxford)2014 Nov53(11):2035-43http://www.ncbi.nlm.nih.gov/pubmed/20153309Multi-center determination of galectin-3 assay performance characteristics: Anatomy of a novel assay for use in heart failure. Clin Biochem. 2010 May; 43(7-8):683-90.Christenson RH, Duh SH, Wu AH, Smith A, Abel G, deFilippi CR, Wang S, Adourian A, Adiletto C, Gardiner P. Clin Biochem2010 May43(7-8):683-90http://www.ncbi.nlm.nih.gov/pubmed/19531748Observations on cryoglobulin testing: II. The association of oligoclonal mixed cryoglobulinemia with cirrhosis in patients infected with hepatitis C virus. J Rheumatol. 2009 Sep; 36(9):1956-7.De Rosa FG, Abel G, Agnello V. J Rheumatol2009 Sep36(9):1956-7http://www.ncbi.nlm.nih.gov/pubmed/10535997Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12766-71.Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX. Proc Natl Acad Sci U S A1999 Oct 2696(22):12766-71http://www.ncbi.nlm.nih.gov/pubmed/10381085A competitive reverse transcription-polymerase chain reaction assay for quantitation of GB virus C/hepatitis G virus RNA that circumvents heteroduplex artifact. J Virol Methods. 1999 May; 79(2):149-59.Liu F, Knight GB, Abel G, Agnello V. J Virol Methods1999 May79(2):149-59http://www.ncbi.nlm.nih.gov/pubmed/9696027Detection of widespread hepatocyte infection in chronic hepatitis C. Hepatology. 1998 Aug; 28(2):573-84.Agnello V, Abel G, Knight GB, Muchmore E. Hepatology1998 Aug28(2):573-84http://www.ncbi.nlm.nih.gov/pubmed/9365090Localization of hepatitis C virus in cutaneous vasculitic lesions in patients with type II cryoglobulinemia. Arthritis Rheum. 1997 Nov; 40(11):2007-15.Agnello V, Abel G. Arthritis Rheum1997 Nov40(11):2007-15http://www.ncbi.nlm.nih.gov/pubmed/8730487The association of hepatitis C virus infection with monoclonal rheumatoid factors bearing the WA cross-idiotype: implications for the etiopathogenesis and therapy of mixed cryoglobulinemia. Clin Exp Rheumatol. 1995 Nov-Dec; 13 Suppl 13:S101-4.Agnello V, Zhang QX, Abel G, Knight GB. Clin Exp Rheumatol1995 Nov-Dec13 Suppl 13:S101-4http://www.ncbi.nlm.nih.gov/pubmed/8028625Interferon alfa-2a for cryoglobulinemia associated with hepatitis C virus. N Engl J Med. 1994 Aug 11; 331(6):400; author reply 401.Agnello V, Knight G, Abel G. N Engl J Med1994 Aug 11331(6):400; author reply 401http://www.ncbi.nlm.nih.gov/pubmed/8216392Hepatitis C virus infection in type II mixed cryoglobulinemia. Arthritis Rheum. 1993 Oct; 36(10):1341-9.Abel G, Zhang QX, Agnello V. Arthritis Rheum1993 Oct36(10):1341-9http://www.ncbi.nlm.nih.gov/pubmed/1334474Stimulation of human monocyte beta-glucan receptors by glucan particles induces production of TNF-alpha and IL-1 beta. Int J Immunopharmacol. 1992 Nov; 14(8):1363-73.Abel G, Czop JK. Int J Immunopharmacol1992 Nov14(8):1363-73http://www.ncbi.nlm.nih.gov/pubmed/1764431Phagocytosis of fluorescent latex microbeads by peritoneal macrophages in different strains of mice: a flow cytometric study. Eur J Immunogenet. 1991 Aug; 18(4):239-45.Abel G, Szöllösi J, Fachet J. Eur J Immunogenet1991 Aug18(4):239-45http://www.ncbi.nlm.nih.gov/pubmed/2807634Effect of lentinan and mannan on phagocytosis of fluorescent latex microbeads by mouse peritoneal macrophages: a flow cytometric study. Int J Immunopharmacol. 1989; 11(6):615-21.Abel G, Szöllösi J, Chihara G, Fachet J. Int J Immunopharmacol198911(6):615-21http://www.ncbi.nlm.nih.gov/pubmed/2464952Neutral-red uptake and expression of monocytic antigens in amniotic-fluid mononuclear phagocytes: evaluation of a novel approach for prenatal diagnosis of neural-tube defects. Am J Reprod Immunol Microbiol. 1988 Nov; 18(3):81-6.Polgár K, Abel G, Sipka S, Papp Z. Am J Reprod Immunol Microbiol1988 Nov18(3):81-6http://www.ncbi.nlm.nih.gov/pubmed/3255417Amniotic fluid mononuclear phagocytes: phenotypes and functions. Acta Paediatr Hung. 1988-1989; 29(1-2):63-7.Polgár K, Abel G, Sipka S, Laczkó J, Papp Z. Acta Paediatr Hung1988-198929(1-2):63-7http://www.ncbi.nlm.nih.gov/pubmed/3207042Immunobiological methods in the prenatal diagnosis and evaluation of foetal neural tube defects. Acta Physiol Hung. 1988; 71(4):551-5.Polgár K, Abel G, Sipka S, Csongor J, Fachet J, Papp Z. Acta Physiol Hung198871(4):551-5http://www.ncbi.nlm.nih.gov/pubmed/2830762Effects of herpesvirus infections on the chemiluminescence induced by zymosan phagocytosis in mouse peritoneal macrophages. Acta Microbiol Hung. 1987; 34(2):115-20.Sipka S, Boldogh I, Abel G, Csongor J, Fachet J, Szegedi G. Acta Microbiol Hung198734(2):115-20http://www.ncbi.nlm.nih.gov/pubmed/2432773Immunocytochemical characterization of amniotic fluid macrophages in cases of fetal neural tube defects. Am J Clin Pathol. 1987 Jan; 87(1):37-42.Polgar K, Abel G, Laczko J, Sipka S, Papp Z. Am J Clin Pathol1987 Jan87(1):37-42http://www.ncbi.nlm.nih.gov/pubmed/3564900Effect of mannozym on the chemiluminescence of phagocytes. Acta Microbiol Hung. 1986; 33(3):263-70.Sipka S, Abel G, Csongor J, Nyirkos P, Fachet J. Acta Microbiol Hung198633(3):263-70http://www.ncbi.nlm.nih.gov/pubmed/3804534Effect of lentinan on pinocytosis in mouse peritoneal macrophages and the murine macrophage cell line C4M phi in vitro. Int J Immunopharmacol. 1986; 8(8):919-24.Abel G, Szöllösi J, Chihara G, Fachet J. Int J Immunopharmacol19868(8):919-24http://www.ncbi.nlm.nih.gov/pubmed/4044098Effect of lentinan on the chemiluminescence produced by human neutrophils and the murine macrophage cell line C4M phi. Int J Immunopharmacol. 1985; 7(5):747-51.Sipka S, Abel G, Csongor J, Chihara G, Fachet J. Int J Immunopharmacol19857(5):747-51http://www.ncbi.nlm.nih.gov/pubmed/2937014The effect of thrombin activated factor XIII, thrombin and plasmin on the chemiluminescence produced by human neutrophils stimulated by opsonized zymosan (Mannozym). Acta Med Hung. 1985; 42(3-4):187-91.Sipka S, Abel G, Czirják L, Csongor J, Szegedi G, Fachet J. Acta Med Hung198542(3-4):187-91http://www.ncbi.nlm.nih.gov/pubmed/6717531Neutral-red uptake by amniotic-fluid macrophages in neural-tube defects: a rapid test. N Engl J Med. 1984 May 31; 310(22):1463-4.Polgár K, Sipka S, Abel G, Papp Z. N Engl J Med1984 May 31310(22):1463-4http://www.ncbi.nlm.nih.gov/pubmed/6197689[A rapid demonstration of phagocytic cells from amniotic fluid in cases of neural tube defects]. Orv Hetil. 1984 Jan 01; 125(1):9-11.Polgár K, Sipka S, Abel G, Papp Z. Orv Hetil1984 Jan 01125(1):9-11Antibodies, Antinuclear29.411451116165375e-0012020-03-15T00:00:002025-05-01T00:00:00Cryoglobulinemia54.396432834767116e-0011993-10-01T00:00:002009-06-16T00:00:00Autoimmune Diseases13.843260569534576e-0012025-05-01T00:00:002025-05-01T00:00:00Point-of-Care Testing13.544904224182169e-0012015-01-01T00:00:002015-01-01T00:00:00Tuberculosis, Multidrug-Resistant13.462550615730775e-0012020-05-01T00:00:002020-05-01T00:00:00Tuberculosis12.517929801300402e-0012020-05-01T00:00:002020-05-01T00:00:00Hepatitis C51.699090438017861e-0011993-10-01T00:00:002009-06-16T00:00:00Drug Resistance, Microbial11.685278888568625e-0012023-12-18T00:00:002023-12-18T00:00:00Diagnostic Tests, Routine21.654591405701317e-0012021-09-23T00:00:002023-12-18T00:00:00Weapons11.605887523471771e-0012020-05-01T00:00:002020-05-01T00:00:00Nucleic Acid Denaturation11.593198238462320e-0012020-05-01T00:00:002020-05-01T00:00:00Global Health11.573082400668998e-0012015-01-01T00:00:002015-01-01T00:00:00Lentinan31.510060997910063e-0011985-01-01T00:00:001989-01-01T00:00:00History, 21st Century11.474735570858443e-0012025-05-01T00:00:002025-05-01T00:00:00Hepacivirus41.430483889335169e-0011994-08-11T00:00:001999-10-26T00:00:00Pathologists11.362513900359453e-0012020-03-15T00:00:002020-03-15T00:00:00History, 20th Century11.322126192010634e-0012025-05-01T00:00:002025-05-01T00:00:00Purpura11.285838455350265e-0011997-11-01T00:00:001997-11-01T00:00:00GTP Phosphohydrolases11.275937659177177e-0012020-07-07T00:00:002020-07-07T00:00:00Phagocytosis61.224555386528950e-0011985-01-01T00:00:001991-08-01T00:00:00COVID-19 Testing11.160002547289887e-0012021-09-23T00:00:002021-09-23T00:00:00Paraproteinemias11.123940354202889e-0012017-12-21T00:00:002017-12-21T00:00:00Cryoglobulins21.107809565445141e-0011997-11-01T00:00:002009-06-16T00:00:00Microfluidics11.101149515903755e-0012020-05-01T00:00:002020-05-01T00:00:00Macrophages101.082421167167350e-0011984-05-31T00:00:001991-08-01T00:00:00Mixed Connective Tissue Disease11.074138592431299e-0012014-06-10T00:00:002014-06-10T00:00:00Laboratories11.056071544260819e-0012017-12-21T00:00:002017-12-21T00:00:00Pathology, Clinical11.026976515454080e-0012017-12-21T00:00:002017-12-21T00:00:00Mannans39.990490523630617e-0021985-01-01T00:00:001989-01-01T00:00:00Interferon-alpha29.850026291386980e-0021993-10-01T00:00:001994-08-11T00:00:00Glucans19.513111168316923e-0021992-11-01T00:00:001992-11-01T00:00:00Brachial Artery19.407736885959463e-0022014-06-10T00:00:002014-06-10T00:00:00Polysaccharides39.081233688423276e-0021985-01-01T00:00:001989-01-01T00:00:00Proto-Oncogene Proteins p21(ras)19.077370349651248e-0022020-07-07T00:00:002020-07-07T00:00:00RNA, Viral58.371996152744483e-0021994-08-11T00:00:002021-09-23T00:00:00Vasodilation17.962390042549933e-0022014-06-10T00:00:002014-06-10T00:00:00Carotid Arteries17.860069716212580e-0022014-06-10T00:00:002014-06-10T00:00:00Flaviviridae27.831680295606289e-0021999-05-01T00:00:001999-10-26T00:00:00Interleukin-117.355800905718443e-0021992-11-01T00:00:001992-11-01T00:00:00Enzyme-Linked Immunosorbent Assay27.281559517398631e-0022010-02-11T00:00:002020-03-15T00:00:00Rheumatoid Factor37.042640534708193e-0021993-10-01T00:00:002009-06-16T00:00:00Galectin 316.850027155832150e-0022010-02-11T00:00:002010-02-11T00:00:00Neural Tube Defects56.572200785312160e-0021984-01-01T00:00:001988-11-01T00:00:00Monocytes36.537776639165600e-0021986-01-01T00:00:001992-11-01T00:00:00Pinocytosis26.230252126133451e-0021984-05-31T00:00:001986-01-01T00:00:00Hepatitis, Viral, Human25.982929358235803e-0021993-10-01T00:00:001999-05-01T00:00:00Receptors, LDL25.935941971961848e-0021997-11-01T00:00:001999-10-26T00:00:00Receptors, Immunologic15.748035176214032e-0021992-11-01T00:00:001992-11-01T00:00:00Point-of-Care Systems15.675914015082566e-0022015-01-01T00:00:002015-01-01T00:00:00Immunoglobulin Idiotypes25.445263144030942e-0021993-10-01T00:00:001995-11-01T00:00:00Receptors, Cell Surface14.995201449240702e-0021992-11-01T00:00:001992-11-01T00:00:00Membrane Proteins14.944950478004426e-0022020-07-07T00:00:002020-07-07T00:00:00Amniotic Fluid54.656173947480317e-0021984-01-01T00:00:001988-11-01T00:00:00Endothelium, Vascular14.647439959450313e-0022014-06-10T00:00:002014-06-10T00:00:00Tumor Necrosis Factor-alpha14.355178648259780e-0021992-11-01T00:00:001992-11-01T00:00:00Humans294.266372294559606e-0021984-01-01T00:00:002025-05-01T00:00:00Thioglycolates24.099537988983863e-0021989-01-01T00:00:001991-08-01T00:00:00Latex24.093659481316569e-0021989-01-01T00:00:001991-08-01T00:00:00Colorectal Neoplasms13.923318259239165e-0022020-07-07T00:00:002020-07-07T00:00:00SARS-CoV-213.821187404973800e-0022021-09-23T00:00:002021-09-23T00:00:00Nucleic Acid Heteroduplexes13.810944534557367e-0021999-05-01T00:00:001999-05-01T00:00:00Fluorescent Antibody Technique, Indirect13.783634235832580e-0022020-03-15T00:00:002020-03-15T00:00:00Immunoglobulin M23.723562305270756e-0021997-11-01T00:00:002009-06-16T00:00:00Nucleic Acid Amplification Techniques13.603193021744260e-0022021-09-23T00:00:002021-09-23T00:00:00Luminescent Measurements53.580421004364246e-0021985-01-01T00:00:001988-01-01T00:00:00Liver Cirrhosis13.473946197178408e-0022009-06-16T00:00:002009-06-16T00:00:00Electrophoresis, Capillary13.410241369312661e-0022017-12-21T00:00:002017-12-21T00:00:00Electrophoresis, Agar Gel13.403099622676366e-0022017-12-21T00:00:002017-12-21T00:00:00Immunoglobulin G33.290459842117237e-0021991-08-01T00:00:002009-06-16T00:00:00In Situ Hybridization23.285071851363372e-0021997-11-01T00:00:001998-08-01T00:00:00Real-Time Polymerase Chain Reaction13.155583353188573e-0022021-09-23T00:00:002021-09-23T00:00:00Specimen Handling13.091313419401312e-0022021-09-23T00:00:002021-09-23T00:00:00Phagocytes33.022961156302800e-0021984-01-01T00:00:001988-11-01T00:00:00Receptors, Virus12.999557158501698e-0021999-10-26T00:00:001999-10-26T00:00:00Endocytosis12.855336862946716e-0021999-10-26T00:00:001999-10-26T00:00:00Cross Reactions22.831242784627075e-0021993-10-01T00:00:001995-11-01T00:00:00Standard of Care12.807758153177369e-0022020-07-07T00:00:002020-07-07T00:00:00Interferon alpha-212.607643776102612e-0021994-08-11T00:00:001994-08-11T00:00:00Sensitivity and Specificity32.586949338637055e-0021991-08-01T00:00:002021-09-23T00:00:00Immunoglobulin A12.561430306601545e-0021997-11-01T00:00:001997-11-01T00:00:00Hepatitis C, Chronic22.556568940371450e-0021998-08-01T00:00:001999-05-01T00:00:00Complement C3b22.544257475341233e-0021985-01-01T00:00:001991-08-01T00:00:00Keratinocytes12.460966443224896e-0021997-11-01T00:00:001997-11-01T00:00:00Viral Load12.305107679958748e-0022021-09-23T00:00:002021-09-23T00:00:00Carotid Intima-Media Thickness12.303016598113100e-0022014-06-10T00:00:002014-06-10T00:00:00Reverse Transcriptase Polymerase Chain Reaction12.299049628420670e-0021999-05-01T00:00:001999-05-01T00:00:00Prenatal Diagnosis32.280061962851875e-0021984-01-01T00:00:001988-11-01T00:00:00Trypsin12.265638605002564e-0021992-11-01T00:00:001992-11-01T00:00:00DNA Mutational Analysis12.249726123005597e-0022020-07-07T00:00:002020-07-07T00:00:00Peritoneal Lavage12.215892970819161e-0021991-08-01T00:00:001991-08-01T00:00:00Peritoneal Cavity22.209013881476316e-0021987-01-01T00:00:001989-01-01T00:00:00Autoantigens12.187992077592790e-0021995-11-01T00:00:001995-11-01T00:00:00COVID-1912.155075373726041e-0022021-09-23T00:00:002021-09-23T00:00:00In Vitro Techniques22.126742070194614e-0021986-01-01T00:00:001989-01-01T00:00:00Amniocentesis32.064442156006529e-0021984-01-01T00:00:001988-01-01T00:00:00Liver21.993342288563374e-0021993-10-01T00:00:001998-08-01T00:00:00Receptors, Fc21.961714503343340e-0021985-01-01T00:00:001991-08-01T00:00:00Flow Cytometry21.922111168112542e-0021989-01-01T00:00:001991-08-01T00:00:00Neutral Red21.836524067730420e-0021984-05-31T00:00:001988-11-01T00:00:00Mice, Inbred Strains11.828702956173162e-0021991-08-01T00:00:001991-08-01T00:00:00Up-Regulation11.815073698789236e-0021997-11-01T00:00:001997-11-01T00:00:00Limit of Detection11.809621257529050e-0022010-02-11T00:00:002010-02-11T00:00:00Hematologic Tests11.755093476358201e-0022009-06-16T00:00:002009-06-16T00:00:00Neutrophils31.729209486531767e-0021985-01-01T00:00:001986-01-01T00:00:00Immune System11.718783944166516e-0021993-10-01T00:00:001993-10-01T00:00:00High-Throughput Nucleotide Sequencing11.684789525979905e-0022020-07-07T00:00:002020-07-07T00:00:00Immunologic Tests11.624228842719364e-0021988-01-01T00:00:001988-01-01T00:00:00Surveys and Questionnaires21.602780688305237e-0022017-12-21T00:00:002020-03-15T00:00:00Complement C311.596507500304737e-0021989-01-01T00:00:001989-01-01T00:00:00Zymosan11.586266490183537e-0021987-01-01T00:00:001987-01-01T00:00:00Time Factors21.474353202155316e-0022014-06-10T00:00:002020-07-07T00:00:00Biopsy11.471967938322792e-0021997-11-01T00:00:001997-11-01T00:00:00Heart Failure11.457515575880043e-0022010-02-11T00:00:002010-02-11T00:00:00Microspheres11.450580293120001e-0021989-01-01T00:00:001989-01-01T00:00:00Herpesviridae Infections11.416668840606720e-0021987-01-01T00:00:001987-01-01T00:00:00Factor XIII11.391174842623617e-0021985-01-01T00:00:001985-01-01T00:00:00Recombinant Proteins11.389166512097117e-0021994-08-11T00:00:001994-08-11T00:00:00Female171.372011536371533e-0021984-01-01T00:00:002020-07-07T00:00:00Fibrinolysin11.367182751825761e-0021985-01-01T00:00:001985-01-01T00:00:00Phenazines11.324340228672917e-0021984-05-31T00:00:001984-05-31T00:00:00Immunohistochemistry11.302390881262533e-0021997-11-01T00:00:001997-11-01T00:00:00Skin11.284209366261866e-0021997-11-01T00:00:001997-11-01T00:00:00Mice71.278281590235733e-0021985-01-01T00:00:002010-02-11T00:00:00Transcription, Genetic21.253365107954660e-0021992-11-01T00:00:001998-08-01T00:00:00Antigens11.234738633779913e-0021988-11-01T00:00:001988-11-01T00:00:00Macrophage Activation11.206727671685462e-0021986-01-01T00:00:001986-01-01T00:00:00Dose-Response Relationship, Drug21.192527172380017e-0021985-01-01T00:00:001992-11-01T00:00:00Thrombin11.130245929374685e-0021985-01-01T00:00:001985-01-01T00:00:00Animals91.108065632853453e-0021985-01-01T00:00:002010-02-11T00:00:00Fluorescent Dyes11.049387862644194e-0021989-01-01T00:00:001989-01-01T00:00:00Aged51.023766831455926e-0021998-08-01T00:00:002020-07-07T00:00:00Mice, Inbred BALB C21.017830682518574e-0021986-01-01T00:00:001987-01-01T00:00:00Adjuvants, Immunologic19.838318840619666e-0031986-01-01T00:00:001986-01-01T00:00:00Biomarkers, Tumor19.463878916244504e-0032020-07-07T00:00:002020-07-07T00:00:00Cells, Cultured29.236973123080066e-0031985-01-01T00:00:001992-11-01T00:00:00Male89.173354320121289e-0031987-01-01T00:00:002020-07-07T00:00:00Middle Aged59.163382780394200e-0031998-08-01T00:00:002020-07-07T00:00:00Pan troglodytes18.602922846658662e-0031998-08-01T00:00:001998-08-01T00:00:00RNA, Messenger18.369556606783828e-0031992-11-01T00:00:001992-11-01T00:00:00Nucleic Acid Hybridization18.319190399158122e-0031999-05-01T00:00:001999-05-01T00:00:00Retrospective Studies28.121695110595750e-0032009-06-16T00:00:002021-09-23T00:00:00alpha-Fetoproteins28.059605632334026e-0031987-01-01T00:00:001988-11-01T00:00:00Evaluation Studies as Topic17.603302627420459e-0031998-08-01T00:00:001998-08-01T00:00:00Adult47.444412159663729e-0031998-08-01T00:00:002020-07-07T00:00:00Blood17.440042244035487e-0031998-08-01T00:00:001998-08-01T00:00:00Aged, 80 and over16.735066724757199e-0032020-07-07T00:00:002020-07-07T00:00:00Cell Line36.445119403850988e-0031985-01-01T00:00:001999-10-26T00:00:00Prognosis16.200420395152631e-0032014-06-10T00:00:002014-06-10T00:00:00Reproducibility of Results16.109487845577897e-0031991-08-01T00:00:001991-08-01T00:00:00Predictive Value of Tests15.945949922733840e-0032009-06-16T00:00:002009-06-16T00:00:00Follow-Up Studies15.894642969922816e-0032014-06-10T00:00:002014-06-10T00:00:00DNA, Viral15.646780533465396e-0031999-05-01T00:00:001999-05-01T00:00:00Virus Replication15.602140659715940e-0031999-10-26T00:00:001999-10-26T00:00:00Antibodies, Monoclonal15.559207168951142e-0031989-01-01T00:00:001989-01-01T00:00:00United States15.480515491861568e-0032020-03-15T00:00:002020-03-15T00:00:00Artifacts15.086315921474690e-0031999-05-01T00:00:001999-05-01T00:00:00Prospective Studies14.742308669804030e-0032014-06-10T00:00:002014-06-10T00:00:00Polymerase Chain Reaction14.678949230214844e-0031998-08-01T00:00:001998-08-01T00:00:00Macrophage-1 Antigen14.334004242019011e-0031988-11-01T00:00:001988-11-01T00:00:00Pregnancy54.241664022019181e-0031984-01-01T00:00:001988-11-01T00:00:00Anencephaly14.067191116857911e-0031987-01-01T00:00:001987-01-01T00:00:00Young Adult14.002918149446789e-0032014-06-10T00:00:002014-06-10T00:00:00Esterases13.994930519056171e-0031987-01-01T00:00:001987-01-01T00:00:00Peroxidases13.921149650428070e-0031987-01-01T00:00:001987-01-01T00:00:00Opsonin Proteins13.714293896580717e-0031986-01-01T00:00:001986-01-01T00:00:00Antigens, Differentiation13.704532334057379e-0031988-11-01T00:00:001988-11-01T00:00:00Histocytochemistry13.676546435695226e-0031987-01-01T00:00:001987-01-01T00:00:00Adolescent13.607980965704231e-0032014-06-10T00:00:002014-06-10T00:00:00Receptors, Complement 3b13.437687214482088e-0031985-01-01T00:00:001985-01-01T00:00:00Microscopy, Electron13.378543692834751e-0031988-01-01T00:00:001988-01-01T00:00:00Receptors, Complement13.318267919584948e-0031985-01-01T00:00:001985-01-01T00:00:00Immunoenzyme Techniques13.221822061935609e-0031987-01-01T00:00:001987-01-01T00:00:00Glial Fibrillary Acidic Protein13.175291613647998e-0031987-01-01T00:00:001987-01-01T00:00:00Peroxidase13.168081164340988e-0031987-01-01T00:00:001987-01-01T00:00:00Herpes Simplex13.116236598261790e-0031987-01-01T00:00:001987-01-01T00:00:00Isoenzymes12.889189536586906e-0031987-01-01T00:00:001987-01-01T00:00:00Superoxide Dismutase12.883013364482444e-0031985-01-01T00:00:001985-01-01T00:00:00Cytomegalovirus Infections12.422543877334315e-0031987-01-01T00:00:001987-01-01T00:00:00Staining and Labeling12.389940458118810e-0031984-01-01T00:00:001984-01-01T00:00:00Phenotype11.208483843294329e-0031988-01-01T00:00:001988-01-01T00:00:00Elisabeth Abeles, M.D.ElisabethAbeles

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryClinical Fellow in SurgeryFellow or Post DocRitika Sunil Abhyankar, M.D.RitikaAbhyankar

Beth Israel Deaconess Medical CenterDivision: Mount Auburn330 Brookline AveBoston, MA 02215617/499-5840

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/34406678Trifluridine/Tipiracil and Regorafenib in Patients with Metastatic Colorectal Cancer: A Retrospective Study at a Tertiary Oncology Center. Oncologist. 2021 12; 26(12):e2161-e2169.Patel AK, Abhyankar R, Brais LK, Duh MS, Barghout VE, Huynh L, Yenikomshian MA, Ng K, Fuchs CS. Oncologist2021 1226(12):e2161-e2169http://www.ncbi.nlm.nih.gov/pubmed/33414136Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions. Clin Cancer Res. 2021 03 15; 27(6):1695-1705.Singh H, Li YY, Spurr LF, Shinagare AB, Abhyankar R, Reilly E, Brais LK, Nag A, Ducar MD, Thorner AR, Shapiro GI, Keller RB, Siletti C, Clark JW, Farago AF, Lin JJ, Demetri GD, Gujrathi R, Kulke MH, MacConaill LE, Ligon AH, Sicinska E, Meyerson ML, Meyerhardt JA, Cherniack AD, Wolpin BM, Ng K, Giannakis M, Hornick JL, Cleary JM. Clin Cancer Res2021 03 1527(6):1695-1705Trifluridine11.771605208441417e-0012021-10-01T00:00:002021-10-01T00:00:00Receptor Protein-Tyrosine Kinases11.002748248456818e-0012021-01-07T00:00:002021-01-07T00:00:00Oncogene Proteins, Fusion19.187229678015949e-0022021-01-07T00:00:002021-01-07T00:00:00Colorectal Neoplasms28.336628696415843e-0022021-01-07T00:00:002021-10-01T00:00:00Protein Kinase Inhibitors15.173863086523526e-0022021-01-07T00:00:002021-01-07T00:00:00Thymine14.437817320021045e-0022021-10-01T00:00:002021-10-01T00:00:00Biomarkers, Tumor13.920071517790304e-0022021-01-07T00:00:002021-01-07T00:00:00Pyrrolidines13.774145132867804e-0022021-10-01T00:00:002021-10-01T00:00:00Phenylurea Compounds13.448341842111097e-0022021-10-01T00:00:002021-10-01T00:00:00Pyridines11.887501334794189e-0022021-10-01T00:00:002021-10-01T00:00:00Molecular Targeted Therapy11.846184568424769e-0022021-01-07T00:00:002021-01-07T00:00:00Longitudinal Studies11.356346343875813e-0022021-10-01T00:00:002021-10-01T00:00:00Prognosis19.782963636144613e-0032021-01-07T00:00:002021-01-07T00:00:00Follow-Up Studies19.300510956949533e-0032021-01-07T00:00:002021-01-07T00:00:00Retrospective Studies15.699400013749445e-0032021-10-01T00:00:002021-10-01T00:00:00Aged14.090796239892598e-0032021-01-07T00:00:002021-01-07T00:00:00Humans23.847571855016492e-0032021-01-07T00:00:002021-10-01T00:00:00Adult13.661773962376549e-0032021-01-07T00:00:002021-01-07T00:00:00Middle Aged13.661530210880538e-0032021-01-07T00:00:002021-01-07T00:00:00Male12.848479764276492e-0032021-01-07T00:00:002021-01-07T00:00:00Female12.696017797517654e-0032021-01-07T00:00:002021-01-07T00:00:00Zaur Abilov, M.D.ZaurAbilov

Beth Israel Deaconess Medical CenterDivision: Gastroenterology330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/38008407Unseen steroids, seen risks: Skin-Cap still contains high-potency glucocorticosteroids 26 years after global scandal. J Am Acad Dermatol. 2024 Nov; 91(5):932-933.Abilov Z, Ioutsi V, Ovcharov M, Mokrysheva N. J Am Acad Dermatol2024 Nov91(5):932-933http://www.ncbi.nlm.nih.gov/pubmed/36557317Parameters of Vitamin D Metabolism in Patients with Hypoparathyroidism. Metabolites. 2022 Dec 16; 12(12).Zhukov A, Povaliaeva A, Abilov Z, Kovaleva E, Usoltseva L, Eremkina A, Ioutsi V, Dzeranova L, Pigarova E, Rozhinskaya L, Mokrysheva N. Metabolites2022 Dec 1612(12)Mohamed Aboseria, M.D.MohamedAboseria

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/30537848Hiccups amelioration following a transcranial direct current stimulation protocol targeting central structures. Aust N Z J Psychiatry. 2019 05; 53(5):477-478.Shiozawa P, Trevizol AP, Cerqueira R, Dias D, Bikson M, Aboseria M, Brietzke E, Cordeiro Q. Aust N Z J Psychiatry2019 0553(5):477-478http://www.ncbi.nlm.nih.gov/pubmed/29994712Discrete Vibro-Tactile Feedback Prevents Object Slippage in Hand Prostheses More Intuitively Than Other Modalities. IEEE Trans Neural Syst Rehabil Eng. 2018 08; 26(8):1577-1584.Aboseria M, Clemente F, Engels LF, Cipriani C. IEEE Trans Neural Syst Rehabil Eng2018 0826(8):1577-1584http://www.ncbi.nlm.nih.gov/pubmed/29067880Modulating affective experience and emotional intelligence with loving kindness meditation and transcranial direct current stimulation: A pilot study. Soc Neurosci. 2019 02; 14(1):10-25.Robinson C, Armenta M, Combs A, Lamphere ML, Garza GJ, Neary J, Wolfe JH, Molina E, Semey DE, McKee CM, Gallegos SJ, Jones AP, Trumbo MC, Al-Azzawi H, Hunter MA, Lieberman G, Coffman BA, Aboseria M, Bikson M, Clark VP, Witkiewitz K. Soc Neurosci2019 0214(1):10-25http://www.ncbi.nlm.nih.gov/pubmed/28804455Comparison of the Long-Term Effect of Positioning the Cathode in tDCS in Tinnitus Patients. Front Aging Neurosci. 2017; 9:217.Rabau S, Shekhawat GS, Aboseria M, Griepp D, Van Rompaey V, Bikson M, Van de Heyning P. Front Aging Neurosci20179:217http://www.ncbi.nlm.nih.gov/pubmed/26397150Effect of Transcranial Direct Current Stimulation Protocol for Treating Depression Among Hemodialysis Patients: A Proof-of-Concept Trial. J ECT. 2016 Jun; 32(2):e3-4.Dias DR, Trevizol AP, Miorin LA, Bikson M, Aboseria M, Shiozawa P, Cordeiro Q. J ECT2016 Jun32(2):e3-4http://www.ncbi.nlm.nih.gov/pubmed/27198577Effects of High-Definition and Conventional tDCS on Response Inhibition. Brain Stimul. 2016 Sep-Oct; 9(5):720-729.Hogeveen J, Grafman J, Aboseria M, David A, Bikson M, Hauner KK. Brain Stimul2016 Sep-Oct9(5):720-729http://www.ncbi.nlm.nih.gov/pubmed/26541374Modeling sequence and quasi-uniform assumption in computational neurostimulation. Prog Brain Res. 2015; 222:1-23.Bikson M, Truong DQ, Mourdoukoutas AP, Aboseria M, Khadka N, Adair D, Rahman A. Prog Brain Res2015222:1-23http://www.ncbi.nlm.nih.gov/pubmed/26279407Left Dorsolateral Prefrontal Cortex Anodal tDCS Effects on Negative Symptoms in Schizophrenia. Brain Stimul. 2015 Sep-Oct; 8(5):989-91.Gomes JS, Shiozawa P, Dias ÁM, Valverde Ducos D, Akiba H, Trevizol AP, Bikson M, Aboseria M, Gadelha A, de Lacerda AL, Cordeiro Q. Brain Stimul2015 Sep-Oct8(5):989-91http://www.ncbi.nlm.nih.gov/pubmed/26032568Targeting negative symptoms in schizophrenia: results from a proof-of-concept trial assessing prefrontal anodic tDCS protocol. Schizophr Res. 2015 Aug; 166(1-3):362-3.Kurimori M, Shiozawa P, Bikson M, Aboseria M, Cordeiro Q. Schizophr Res2015 Aug166(1-3):362-3Feedback, Sensory15.424527755166233e-0012018-06-29T00:00:002018-06-29T00:00:00Touch14.788382937058667e-0012018-06-29T00:00:002018-06-29T00:00:00Transcranial Direct Current Stimulation53.983979371896559e-0012015-05-29T00:00:002018-12-11T00:00:00Hand13.766540582482797e-0012018-06-29T00:00:002018-06-29T00:00:00Prostheses and Implants13.476427759509297e-0012018-06-29T00:00:002018-06-29T00:00:00Prosthesis Design13.435221459032343e-0012018-06-29T00:00:002018-06-29T00:00:00Hiccup11.486086915917441e-0012018-12-11T00:00:002018-12-11T00:00:00Emotional Intelligence11.255697453193370e-0012017-10-31T00:00:002017-10-31T00:00:00Vibration11.203242435124412e-0012018-06-29T00:00:002018-06-29T00:00:00Fingers11.131230874493599e-0012018-06-29T00:00:002018-06-29T00:00:00Reaction Time21.107489839275911e-0012016-04-22T00:00:002018-06-29T00:00:00Healthy Volunteers11.048150952219429e-0012018-06-29T00:00:002018-06-29T00:00:00Meditation11.041715179916632e-0012017-10-31T00:00:002017-10-31T00:00:00Therapy, Computer-Assisted11.002095241281526e-0012015-09-26T00:00:002015-09-26T00:00:00Brain Stem19.886253445398412e-0022018-12-11T00:00:002018-12-11T00:00:00Electromyography19.746989357610995e-0022018-06-29T00:00:002018-06-29T00:00:00Inhibition, Psychological19.415393221280145e-0022016-04-22T00:00:002016-04-22T00:00:00Robotics18.778717948006938e-0022018-06-29T00:00:002018-06-29T00:00:00Frontal Lobe17.768420860468291e-0022016-04-22T00:00:002016-04-22T00:00:00Electric Stimulation Therapy17.295347252955828e-0022015-09-26T00:00:002015-09-26T00:00:00Executive Function16.511358780567028e-0022016-04-22T00:00:002016-04-22T00:00:00Renal Dialysis16.228992661969913e-0022016-06-01T00:00:002016-06-01T00:00:00Depressive Disorder15.139628822826528e-0022016-06-01T00:00:002016-06-01T00:00:00Computer Simulation14.534788446117652e-0022015-09-26T00:00:002015-09-26T00:00:00Schizophrenia13.119604275751210e-0022015-05-29T00:00:002015-05-29T00:00:00Psychiatric Status Rating Scales22.950246144816406e-0022015-05-29T00:00:002016-06-01T00:00:00Young Adult22.626782598817470e-0022017-10-31T00:00:002018-06-29T00:00:00Adult42.037289231630995e-0022015-05-29T00:00:002018-06-29T00:00:00Male51.790280824837070e-0022015-05-29T00:00:002018-06-29T00:00:00Brain11.743240352570215e-0022015-09-26T00:00:002015-09-26T00:00:00Schizophrenic Psychology11.741153402232226e-0022015-05-29T00:00:002015-05-29T00:00:00Female51.694457874283435e-0022015-05-29T00:00:002018-06-29T00:00:00Bayes Theorem11.692410821987168e-0022016-04-22T00:00:002016-04-22T00:00:00Humans71.470866455464140e-0022015-05-29T00:00:002018-12-11T00:00:00Pilot Projects11.287797116500752e-0022017-10-31T00:00:002017-10-31T00:00:00Neuropsychological Tests11.208978224763354e-0022016-04-22T00:00:002016-04-22T00:00:00Double-Blind Method11.117955547121380e-0022016-06-01T00:00:002016-06-01T00:00:00Adolescent14.564356379856751e-0032017-10-31T00:00:002017-10-31T00:00:00Animals13.092970776473564e-0032015-09-26T00:00:002015-09-26T00:00:00Aged12.973472971641955e-0032016-06-01T00:00:002016-06-01T00:00:00Middle Aged12.661452802447475e-0032016-06-01T00:00:002016-06-01T00:00:00Yossof Galal Abouelnagah, M.B.,B.Ch.YossofAbouelnagah

Beth Israel Deaconess Medical Center One Deaconess RdBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyResearch Fellow in RadiologyFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=307912510YAbouelnagahMartin Julian Abrahamson, M.B.,Ch.B.MartinAbrahamson

Beth Israel Deaconess Medical CenterDivision of Endocrine GZ - 811330 Brookline AveBoston, MA 02215617/667-934442.33839600000000-71.10840300000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineEndocrinologyAssociate Professor of MedicineAssociate Professorhttp://www.ncbi.nlm.nih.gov/pubmed/38457639Disparities Between Teleretinal Imaging Findings and Patient-Reported Diabetic Retinopathy Status and Follow-up Eye Care Interval: A 10-Year Prospective Study. Diabetes Care. 2024 Jun 01; 47(6):970-977.Silva PS, Cavallerano JD, Sun JK, Tolson AM, Tolls D, Abrahamson MJ, Aiello LM, Aiello LP. Diabetes Care2024 Jun 0147(6):970-977http://www.ncbi.nlm.nih.gov/pubmed/31960258Clinical Considerations When Initiating and Titrating Insulin Degludec/Liraglutide (IDegLira) in People with Type 2 Diabetes. Drugs. 2020 Feb; 80(2):147-165.Harris S, Abrahamson MJ, Ceriello A, Charpentier G, Evans M, Lehmann R, Liebl A, Linjawi S, Holt RIG, Hosszúfalusi N, Rutten G, Vilsbøll T. Drugs2020 Feb80(2):147-165http://www.ncbi.nlm.nih.gov/pubmed/32022600CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2020 EXECUTIVE SUMMARY. Endocr Pract. 2020 01; 26(1):107-139.Garber AJ, Handelsman Y, Grunberger G, Einhorn D, Abrahamson MJ, Barzilay JI, Blonde L, Bush MA, DeFronzo RA, Garber JR, Garvey WT, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Perreault L, Rosenblit PD, Samson S, Umpierrez GE. Endocr Pract2020 0126(1):107-139http://www.ncbi.nlm.nih.gov/pubmed/31551412Effect of diabetes-specific nutrition formulas on satiety and hunger hormones in patients with type 2 diabetes. Nutr Diabetes. 2019 09 24; 9(1):26.Mottalib A, Abrahamson MJ, Pober DM, Polak R, Eldib AH, Tomah S, Ashrafzadeh S, Hamdy O. Nutr Diabetes2019 09 249(1):26http://www.ncbi.nlm.nih.gov/pubmed/31371861Virtually Better Diabetes Care? Clin Diabetes. 2019 Jul; 37(3):284-286.Vamvini MT, Dushay JR, Abrahamson MJ. Clin Diabetes2019 Jul37(3):284-286http://www.ncbi.nlm.nih.gov/pubmed/30742570CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2019 EXECUTIVE SUMMARY. Endocr Pract. 2019 01; 25(1):69-100.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, DeFronzo RA, Einhorn D, Fonseca VA, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. Endocr Pract2019 0125(1):69-100http://www.ncbi.nlm.nih.gov/pubmed/30103624Approaches to rapid acting insulin intensification in patients with type 2 diabetes mellitus not achieving glycemic targets. Ann Med. 2018 09; 50(6):453-460.Migdal A, Abrahamson M, Peters A, Vint N. Ann Med2018 0950(6):453-460http://www.ncbi.nlm.nih.gov/pubmed/29368965CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2018 EXECUTIVE SUMMARY. Endocr Pract. 2018 01; 24(1):91-120.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, DeFronzo RA, Einhorn D, Fonseca VA, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. Endocr Pract2018 0124(1):91-120http://www.ncbi.nlm.nih.gov/pubmed/28376310Improving patients' home cooking - A case series of participation in a remote culinary coaching program. Appl Physiol Nutr Metab. 2017 Aug; 42(8):893-896.Polak R, Pober DM, Budd MA, Silver JK, Phillips EM, Abrahamson MJ. Appl Physiol Nutr Metab2017 Aug42(8):893-896http://www.ncbi.nlm.nih.gov/pubmed/28095040CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2017 EXECUTIVE SUMMARY. Endocr Pract. 2017 02; 23(2):207-238.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, DeFronzo RA, Einhorn D, Fonseca VA, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. Endocr Pract2017 0223(2):207-238http://www.ncbi.nlm.nih.gov/pubmed/27699399Should We Screen for Type 2 Diabetes?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2016 10 04; 165(7):509-516.Smetana GW, Abrahamson MJ, Rind DM. Ann Intern Med2016 10 04165(7):509-516http://www.ncbi.nlm.nih.gov/pubmed/27402243Changes in HbA1c and Weight Following Transition to Continuous Subcutaneous Insulin Infusion Therapy in Adults With Type 1 Diabetes. J Diabetes Sci Technol. 2017 01; 11(1):83-86.Mehta SN, Andersen HU, Abrahamson MJ, Wolpert HA, Hommel EE, McMullen W, Ridderstråle M. J Diabetes Sci Technol2017 0111(1):83-86http://www.ncbi.nlm.nih.gov/pubmed/27176141IMPROVEMENTS IN METABOLIC CONTROL IN ADULTS WITH TYPE 2 DIABETES FOLLOWING REFERRAL TO A DIABETES CENTER, 2005-2010. Endocr Pract. 2016 Jun; 22(6):689-98.Mehta SN, Goldfine AB, Abrahamson MJ, McMullen W, Laffel LM. Endocr Pract2016 Jun22(6):689-98http://www.ncbi.nlm.nih.gov/pubmed/26731084CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2016 EXECUTIVE SUMMARY. Endocr Pract. 2016 Jan; 22(1):84-113.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, DeFronzo RA, Einhorn D, Fonseca VA, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Henry RR, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. Endocr Pract2016 Jan22(1):84-113http://www.ncbi.nlm.nih.gov/pubmed/26645932Utilization of a Cloud-Based Diabetes Management Program for Insulin Initiation and Titration Enables Collaborative Decision Making Between Healthcare Providers and Patients. Diabetes Technol Ther. 2016 Feb; 18(2):59-67.Hsu WC, Lau KH, Huang R, Ghiloni S, Le H, Gilroy S, Abrahamson M, Moore J. Diabetes Technol Ther2016 Feb18(2):59-67http://www.ncbi.nlm.nih.gov/pubmed/26642101CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2015 EXECUTIVE SUMMARY. Endocr Pract. 2015 Dec; 21(12):1403-14.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, Davidson MB, Einhorn D, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. Endocr Pract2015 Dec21(12):1403-14http://www.ncbi.nlm.nih.gov/pubmed/25798733The 2015 standards for diabetes care: maintaining a patient-centered approach. Ann Intern Med. 2015 Jun 02; 162(11):785-6.Romeo GR, Abrahamson MJ. Ann Intern Med2015 Jun 02162(11):785-6http://www.ncbi.nlm.nih.gov/pubmed/25877012AACE/ACE comprehensive diabetes management algorithm 2015. Endocr Pract. 2015 Apr; 21(4):438-47.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, Davidson MB, Einhorn D, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez G, Davidson MH. Endocr Pract2015 Apr21(4):438-47http://www.ncbi.nlm.nih.gov/pubmed/25538313Should sulfonylureas remain an acceptable first-line add-on to metformin therapy in patients with type 2 diabetes? Yes, they continue to serve us well! Diabetes Care. 2015 Jan; 38(1):166-9.Abrahamson MJ. Diabetes Care2015 Jan38(1):166-9http://www.ncbi.nlm.nih.gov/pubmed/25568831Innovation in diabetes care: improving consumption of healthy food through a "chef coaching" program: a case report. Glob Adv Health Med. 2014 Nov; 3(6):42-8.Polak R, Dill D, Abrahamson MJ, Pojednic RM, Phillips EM. Glob Adv Health Med2014 Nov3(6):42-8http://www.ncbi.nlm.nih.gov/pubmed/24899464Roux-en-Y gastric bypass surgery or lifestyle with intensive medical management in patients with type 2 diabetes: feasibility and 1-year results of a randomized clinical trial. JAMA Surg. 2014 Jul; 149(7):716-26.Halperin F, Ding SA, Simonson DC, Panosian J, Goebel-Fabbri A, Wewalka M, Hamdy O, Abrahamson M, Clancy K, Foster K, Lautz D, Vernon A, Goldfine AB. JAMA Surg2014 Jul149(7):716-26http://www.ncbi.nlm.nih.gov/pubmed/24934464Glycemic management in patients with coronary artery disease and prediabetes or type 2 diabetes mellitus. Circulation. 2014 Jun 17; 129(24):2567-73.Goldfine AB, Phua EJ, Abrahamson MJ. Circulation2014 Jun 17129(24):2567-73http://www.ncbi.nlm.nih.gov/pubmed/24733201Diabetes, prediabetes, and glycemic control in the United States: challenges and opportunities. Ann Intern Med. 2014 Apr 15; 160(8):572-3.Middelbeek RJ, Abrahamson MJ. Ann Intern Med2014 Apr 15160(8):572-3http://www.ncbi.nlm.nih.gov/pubmed/24567195Barriers and facilitators to self-care communication during medical appointments in the United States for adults with type 2 diabetes. Chronic Illn. 2014 Dec; 10(4):303-13.Ritholz MD, Beverly EA, Brooks KM, Abrahamson MJ, Weinger K. Chronic Illn2014 Dec10(4):303-13http://www.ncbi.nlm.nih.gov/pubmed/23337143Do ethnic disparities extend to subspecialty diabetes care? Endocr Pract. 2013 May-Jun; 19(3):431-8.Okeke EN, Keenan HA, Weinger K, Abrahamson MJ, Hsu WC. Endocr Pract2013 May-Jun19(3):431-8http://www.ncbi.nlm.nih.gov/pubmed/23816937American Association of Clinical Endocrinologists' comprehensive diabetes management algorithm 2013 consensus statement--executive summary. Endocr Pract. 2013 May-Jun; 19(3):536-57.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, Davidson MB, Einhorn D, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE, Davidson MH. Endocr Pract2013 May-Jun19(3):536-57http://www.ncbi.nlm.nih.gov/pubmed/23598536AACE comprehensive diabetes management algorithm 2013. Endocr Pract. 2013 Mar-Apr; 19(2):327-36.Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, Davidson MB, Einhorn D, Garvey WT, Grunberger G, Handelsman Y, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez G, Davidson MH. Endocr Pract2013 Mar-Apr19(2):327-36http://www.ncbi.nlm.nih.gov/pubmed/23439167Changing prescribing patterns of type 2 diabetes medications from 2002-2010: an electronic health record-based evaluation. J Diabetes Sci Technol. 2013 Jan 01; 7(1):119-22.Mehta SN, Goldfine AB, Abrahamson MJ, DiVincenzo R, Laffel LM. J Diabetes Sci Technol2013 Jan 017(1):119-22http://www.ncbi.nlm.nih.gov/pubmed/22826455Assessment of emotional struggles in type 2 diabetes: patient perspectives. Diabetes Care. 2012 Aug; 35(8):e62.Beverly EA, Brooks KM, Ritholz MD, Abrahamson MJ, Weinger K. Diabetes Care2012 Aug35(8):e62http://www.ncbi.nlm.nih.gov/pubmed/22822902Intensification of insulin therapy in patients with type 2 diabetes mellitus: an algorithm for basal-bolus therapy. Ann Med. 2012 Dec; 44(8):836-46.Abrahamson MJ, Peters A. Ann Med2012 Dec44(8):836-46http://www.ncbi.nlm.nih.gov/pubmed/22549299A qualitative study of perceived responsibility and self-blame in type 2 diabetes: reflections of physicians and patients. J Gen Intern Med. 2012 Sep; 27(9):1180-7.Beverly EA, Ritholz MD, Brooks KM, Hultgren BA, Lee Y, Abrahamson MJ, Weinger K. J Gen Intern Med2012 Sep27(9):1180-7http://www.ncbi.nlm.nih.gov/pubmed/22459987Quantification of concordance and discordance between apolipoprotein-B and the currently recommended non-HDL-cholesterol goals for cardiovascular risk assessment in patients with diabetes and hypertriglyceridemia. Diabetes Res Clin Pract. 2012 Jul; 97(1):51-6.Ganda OP, Jumes CG, Abrahamson MJ, Molla M. Diabetes Res Clin Pract2012 Jul97(1):51-6http://www.ncbi.nlm.nih.gov/pubmed/22002972Physicians' perceptions of the type 2 diabetes multi-disciplinary treatment team: a qualitative study. Diabetes Educ. 2011 Nov-Dec; 37(6):794-800.Ritholz MD, Beverly EA, Abrahamson MJ, Brooks KM, Hultgren BA, Weinger K. Diabetes Educ2011 Nov-Dec37(6):794-800http://www.ncbi.nlm.nih.gov/pubmed/21411508Understanding physicians' challenges when treating type 2 diabetic patients' social and emotional difficulties: a qualitative study. Diabetes Care. 2011 May; 34(5):1086-8.Beverly EA, Hultgren BA, Brooks KM, Ritholz MD, Abrahamson MJ, Weinger K. Diabetes Care2011 May34(5):1086-8http://www.ncbi.nlm.nih.gov/pubmed/20394887Basal insulins: Pharmacological properties and patient perspectives. Prim Care Diabetes. 2010 Apr; 4 Suppl 1:S19-23.Abrahamson MJ. Prim Care Diabetes2010 Apr4 Suppl 1:S19-23http://www.ncbi.nlm.nih.gov/pubmed/20394890Insulin detemir: A historical perspective on a modern basal insulin analogue. Prim Care Diabetes. 2010 Apr; 4 Suppl 1:S31-42.Meneghini L, Liebl A, Abrahamson MJ. Prim Care Diabetes2010 Apr4 Suppl 1:S31-42http://www.ncbi.nlm.nih.gov/pubmed/20398575Insulin therapy for type 2 diabetes: making it work. J Fam Pract. 2010 Apr; 59(4):E1-8.Dushay J, Abrahamson MJ. J Fam Pract2010 Apr59(4):E1-8http://www.ncbi.nlm.nih.gov/pubmed/17920355Comparison of outcomes using sirolimus-eluting stenting in diabetic versus nondiabetic patients with comparison of insulin versus non-insulin therapy in the diabetic patients. Am J Cardiol. 2007 Oct 15; 100(8):1187-91.Kumar R, Lee TT, Jeremias A, Ruisi CP, Sylvia B, Magallon J, Kirtane AJ, Bigelow B, Abrahamson M, Pinto DS, Ho KK, Cohen DJ, Carrozza JP, Cutlip DE. Am J Cardiol2007 Oct 15100(8):1187-91http://www.ncbi.nlm.nih.gov/pubmed/17213403A 74-year-old woman with diabetes. JAMA. 2007 Jan 10; 297(2):196-204.Abrahamson MJ. JAMA2007 Jan 10297(2):196-204http://www.ncbi.nlm.nih.gov/pubmed/16686819Medicare coverage for patients with diabetes. A national plan with individual consequences. J Gen Intern Med. 2006 Apr; 21(4):386-92.Ashkenazy R, Abrahamson MJ. J Gen Intern Med2006 Apr21(4):386-92http://www.ncbi.nlm.nih.gov/pubmed/16461058Comparison of aspirin resistance in type 1 versus type 2 diabetes mellitus. Am J Cardiol. 2006 Feb 15; 97(4):567-70.Mehta SS, Silver RJ, Aaronson A, Abrahamson M, Goldfine AB. Am J Cardiol2006 Feb 1597(4):567-70http://www.ncbi.nlm.nih.gov/pubmed/18370723Evaluating the cardiovascular effects of the thiazolidinediones and their place in the management of type 2 diabetes in relation to the metabolic syndrome. 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Education13.213511322548155e-0012017-04-04T00:00:002017-04-04T00:00:00Metformin22.861750591091538e-0012004-03-08T00:00:002015-01-01T00:00:00Glycated Hemoglobin92.564184266005394e-0011987-02-07T00:00:002018-08-25T00:00:00Postprandial Period32.435593659966551e-0012004-03-08T00:00:002019-09-24T00:00:00Algorithms92.370354997892605e-0012012-07-23T00:00:002020-01-01T00:00:00Patient-Centered Care12.173803927520928e-0012015-06-02T00:00:002015-06-02T00:00:00Hyperglycemic Hyperosmolar Nonketotic Coma12.113774390139710e-0012004-07-01T00:00:002004-07-01T00:00:00Insurance, Pharmaceutical Services12.036905078594468e-0012006-04-01T00:00:002006-04-01T00:00:00Insulin Detemir21.644904352090393e-0012010-04-01T00:00:002010-04-01T00:00:00Blood Glucose Self-Monitoring41.538103906677230e-0012004-03-08T00:00:002020-01-01T00:00:00Satiation11.513744518865427e-0012019-09-24T00:00:002019-09-24T00:00:00Food, Formulated11.476671522728489e-0012019-09-24T00:00:002019-09-24T00:00:00Insulin, Short-Acting11.466624076113311e-0012018-08-25T00:00:002018-08-25T00:00:00Life Style71.448009423237244e-0012004-12-01T00:00:002018-01-17T00:00:00Liraglutide11.430262715183935e-0012020-02-01T00:00:002020-02-01T00:00:00Estrogen Replacement Therapy11.385853960261153e-0012004-12-01T00:00:002004-12-01T00:00:00Diabetic Angiopathies31.374994911750469e-0012003-12-08T00:00:002012-03-28T00:00:00Hunger11.350179827999221e-0012019-09-24T00:00:002019-09-24T00:00:00Anticholesteremic Agents11.335707935004681e-0012004-12-01T00:00:002004-12-01T00:00:00Self Care21.332096203319626e-0012012-05-02T00:00:002014-02-24T00:00:00Diabetes Complications21.326702611656890e-0012013-03-01T00:00:002015-06-02T00:00:00Diet Therapy11.260153562804678e-0012018-01-17T00:00:002018-01-17T00:00:00Weight Gain31.236648392034448e-0012012-07-23T00:00:002018-08-25T00:00:00Hypoglycemia31.236289161125308e-0012010-04-01T00:00:002018-08-25T00:00:00Endocrinology31.183422622732668e-0012011-10-14T00:00:002018-01-17T00:00:00Women's 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Relations38.503547499720840e-0022011-03-16T00:00:002014-02-24T00:00:00Attitude of Health Personnel48.153484593676404e-0022011-03-16T00:00:002014-02-24T00:00:00Insulin, Isophane18.126423542199308e-0022010-04-01T00:00:002010-04-01T00:00:00Apolipoproteins B18.047503706101654e-0022012-03-28T00:00:002012-03-28T00:00:00Communication Barriers17.992361141374609e-0022014-02-24T00:00:002014-02-24T00:00:00Drug Administration Schedule27.757783882556130e-0022004-07-01T00:00:002010-04-01T00:00:00Asian17.716098983147332e-0022015-06-02T00:00:002015-06-02T00:00:00Insulin Glargine17.668459483033147e-0022010-04-01T00:00:002010-04-01T00:00:00Hyperthyroxinemia17.614796273228634e-0021989-02-18T00:00:001989-02-18T00:00:00Drug Combinations27.608806432676955e-0022010-04-01T00:00:002020-02-01T00:00:00Dose-Response Relationship, Drug37.376202318951608e-0022004-07-01T00:00:002018-08-25T00:00:00Hypertriglyceridemia17.268881197678802e-0022012-03-28T00:00:002012-03-28T00:00:00Administration, Oral27.262238158332364e-0022003-04-01T00:00:002010-04-01T00:00:00Diet, Healthy17.260451470652372e-0022017-04-04T00:00:002017-04-04T00:00:00Nutritional Status16.989077275518350e-0022017-04-04T00:00:002017-04-04T00:00:00Life Expectancy16.793465464175096e-0022015-06-02T00:00:002015-06-02T00:00:00Medicare16.643825249416702e-0022006-04-01T00:00:002006-04-01T00:00:00Triiodothyronine16.537243567124776e-0021989-02-18T00:00:001989-02-18T00:00:00Age Factors36.332167018601086e-0022004-07-01T00:00:002018-08-25T00:00:00United States136.291084542768680e-0022004-12-01T00:00:002020-01-01T00:00:00Patient Preference16.277616064093859e-0022015-06-02T00:00:002015-06-02T00:00:00Clinical Decision-Making15.984814083291622e-0022015-12-08T00:00:002015-12-08T00:00:00Formularies as Topic15.899227431304633e-0022006-04-01T00:00:002006-04-01T00:00:00Consensus35.802073687115020e-0022017-01-17T00:00:002020-01-01T00:00:00Medication Adherence15.755444971419349e-0022015-06-02T00:00:002015-06-02T00:00:00Proprotein 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Assessment32.294418111920547e-0022004-07-01T00:00:002014-07-01T00:00:00Survival Analysis12.262419484212846e-0022004-07-01T00:00:002004-07-01T00:00:00Europe12.207311939719723e-0022018-08-25T00:00:002018-08-25T00:00:00Leptin12.198403951110633e-0022019-09-24T00:00:002019-09-24T00:00:00Critical Illness12.133514249314899e-0022004-07-01T00:00:002004-07-01T00:00:00Decision Trees12.119561744386795e-0022013-03-01T00:00:002013-03-01T00:00:00Appointments and Schedules11.960622918900511e-0022014-02-24T00:00:002014-02-24T00:00:00Blood Pressure21.921800009909509e-0022015-12-01T00:00:002016-01-01T00:00:00Counseling11.895960686429878e-0022018-01-17T00:00:002018-01-17T00:00:00Behavior Therapy11.889795829039619e-0022016-01-01T00:00:002016-01-01T00:00:00Treatment Outcome41.866823466003715e-0022004-07-01T00:00:002014-07-01T00:00:00Trust11.817078881048093e-0022014-02-24T00:00:002014-02-24T00:00:00Thyrotoxicosis11.753885526036464e-0021989-02-18T00:00:001989-02-18T00:00:00Quality of Life21.747235261790001e-0022004-12-01T00:00:002014-07-01T00:00:00Sex Distribution11.612097727529641e-0022012-03-28T00:00:002012-03-28T00:00:00Disease Management11.587231431272557e-0022018-01-17T00:00:002018-01-17T00:00:00Lipid Metabolism11.584620852047870e-0022015-12-01T00:00:002015-12-01T00:00:00Evidence-Based Medicine11.566532047194495e-0022018-08-25T00:00:002018-08-25T00:00:00Asian People11.544631697904728e-0022013-05-01T00:00:002013-05-01T00:00:00Randomized Controlled Trials as Topic11.511079651711907e-0022003-12-08T00:00:002003-12-08T00:00:00Smoking Cessation11.488045734376469e-0022018-01-17T00:00:002018-01-17T00:00:00Fear11.398548211339213e-0022014-02-24T00:00:002014-02-24T00:00:00Israel11.374303258243985e-0022007-08-02T00:00:002007-08-02T00:00:00Health Care Surveys11.356061411872636e-0022011-10-14T00:00:002011-10-14T00:00:00Nutrition Surveys11.350866000030779e-0022012-03-28T00:00:002012-03-28T00:00:00Prognosis11.245154115902275e-0022004-07-01T00:00:002004-07-01T00:00:00Prospective Studies21.241793357492826e-0022007-08-02T00:00:002024-06-01T00:00:00Lipids11.225724173160545e-0022014-07-01T00:00:002014-07-01T00:00:00Feasibility Studies11.196209472923825e-0022014-07-01T00:00:002014-07-01T00:00:00Platelet Aggregation11.189429121808321e-0022006-01-06T00:00:002006-01-06T00:00:00Aged, 80 and over21.134209770873868e-0022004-07-01T00:00:002006-01-06T00:00:00Sleep11.106588796551862e-0022018-01-17T00:00:002018-01-17T00:00:00Overweight11.097647923897404e-0022013-03-01T00:00:002013-03-01T00:00:00Combined Modality Therapy11.066399874476965e-0022013-03-01T00:00:002013-03-01T00:00:00Practice Guidelines as Topic11.064981257306940e-0022018-08-25T00:00:002018-08-25T00:00:00Patient Acceptance of Health Care11.044067581636499e-0022015-12-08T00:00:002015-12-08T00:00:00Angioplasty, Balloon, Coronary11.020322344379486e-0022007-08-02T00:00:002007-08-02T00:00:00Hispanic or Latino19.848393978964892e-0032013-05-01T00:00:002013-05-01T00:00:00Drug Resistance19.794643469543299e-0032006-01-06T00:00:002006-01-06T00:00:00Cholesterol, HDL19.525912381799404e-0032006-01-06T00:00:002006-01-06T00:00:00Communication19.150574785139790e-0032014-02-24T00:00:002014-02-24T00:00:00Boston19.035692388616512e-0032011-10-14T00:00:002011-10-14T00:00:00Hypertension18.224608752795666e-0032018-01-17T00:00:002018-01-17T00:00:00Blood Vessel Prosthesis Implantation18.096623045047921e-0032007-08-02T00:00:002007-08-02T00:00:00Black or African American17.837453542795372e-0032013-05-01T00:00:002013-05-01T00:00:00Drug Delivery Systems17.481885409768217e-0032007-08-02T00:00:002007-08-02T00:00:00Diagnosis, Differential16.395225890474486e-0031989-02-18T00:00:001989-02-18T00:00:00Biomarkers15.742210026659651e-0032014-07-01T00:00:002014-07-01T00:00:00Sex Factors15.598672977267435e-0032006-01-06T00:00:002006-01-06T00:00:00Time Factors15.288148718834994e-0032013-01-01T00:00:002013-01-01T00:00:00Registries15.176293131190469e-0032007-08-02T00:00:002007-08-02T00:00:00Young Adult14.625714887571297e-0032016-07-11T00:00:002016-07-11T00:00:00Adolescent14.169331133947478e-0032016-07-11T00:00:002016-07-11T00:00:00Follow-Up Studies13.665084845815774e-0032007-08-02T00:00:002007-08-02T00:00:00Retrospective Studies13.179766736284530e-0032013-05-01T00:00:002013-05-01T00:00:00Animals12.588128078191093e-0032013-03-01T00:00:002013-03-01T00:00:00Matthew Abrams, M.D.MatthewAbrams

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiation OncologyAssistant Professor of Radiation OncologyAssistant ProfessorBrandeis UniversityWaltham, MAB.S.06/2008BiologyTufts University School of MedicineBoston, MAM.D.06/2012MedicineTufts Medical CenterBoston, MA06/2017Radiation Oncologyhttp://www.ncbi.nlm.nih.gov/pubmed/41703382Medicaid Coverage Restrictions and On-Label Buprenorphine Prescribing for Chronic Pain. J Gen Intern Med. 2026 Feb 17.Nguemeni Tiako MJ, Abrams MP, Pinto Taylor E. J Gen Intern Med2026 Feb 17http://www.ncbi.nlm.nih.gov/pubmed/40965565Beyond Clinical Competence: Preparing Psychiatry Trainees for Leadership in Complex Systems. Acad Psychiatry. 2025 Dec; 49(6):578-579.Shen MR, Zhang R, Sarma KV, Williams J, Liu AC, Khaira P, Tom A, Rached G, Rossopoulos T, Abrams M. Acad Psychiatry2025 Dec49(6):578-579http://www.ncbi.nlm.nih.gov/pubmed/40536540CT imaging findings following treatment with combination SBRT and chemotherapy versus stand-alone chemotherapy for locally advanced pancreatic adenocarcinoma. Abdom Radiol (NY). 2026 Jan; 51(1):97-103.Gudla V, Bezuidenhout AF, Mendiratta-Lala M, Brook OR, Raptopoulos V, Abrams MJ, Brook A, Siewert B. Abdom Radiol (NY)2026 Jan51(1):97-103http://www.ncbi.nlm.nih.gov/pubmed/39898531Exploring Preferences for Communication and Care Among Hospitalized Patients With Opioid Use Disorder: A Qualitative Descriptive Study. J Addict Med. 2025 Jul-Aug 01; 19(4):423-429.Davis MH, French R, Crowe M, Abrams M, Edwards G, Aronowitz S, Mandell DS, Lowenstein M. J Addict Med2025 Jul-Aug 0119(4):423-429http://www.ncbi.nlm.nih.gov/pubmed/39733966Defining an Undergraduate Radiation Oncology Microclerkship Using the Delphi Method. Pract Radiat Oncol. 2025 Jul-Aug; 15(4):320-325.Willcox J, Gregg AT, Braunstein S, Mattes MD, Gunther J, Abrams M. Pract Radiat Oncol2025 Jul-Aug15(4):320-325http://www.ncbi.nlm.nih.gov/pubmed/38992668Understanding learners' experiences across three major transitions in undergraduate medical education. BMC Med Educ. 2024 Jul 11; 24(1):748.Weyant-Cheeseman ME, Abrams MP, Toselli N, Castiglioni A. BMC Med Educ2024 Jul 1124(1):748http://www.ncbi.nlm.nih.gov/pubmed/38875553Association Between Online Reviews of Substance Use Disorder Treatment Facilities and Drug-Induced Mortality Rates: Cross-Sectional Analysis. JMIR AI. 2023 Dec 29; 2:e46317.Abrams MP, Merchant RM, Meisel ZF, Pelullo AP, Chandra Guntuku S, Agarwal AK. JMIR AI2023 Dec 292:e46317http://www.ncbi.nlm.nih.gov/pubmed/37468769Evaluation of a Radiation Oncology Microclerkship as a Component of Medical Student Education. J Cancer Educ. 2023 12; 38(6):1861-1864.Subramanian S, Parikh P, Kra JA, Maldjian PD, Walther S, Kim S, DeNunzio NJ, Abrams MJ, Braunstein SE, Gunther JR, Mattes MD. J Cancer Educ2023 1238(6):1861-1864http://www.ncbi.nlm.nih.gov/pubmed/38313044Translating and disseminating a localised economic model to support implementation of the 'Ending the HIV Epidemic' initiative to public health policymakers. Evid Policy. 2023 Nov; 19(4):554-571.Abrams MP, Weiner J, Piske M, Enns B, Krebs E, Zang X, Nosyk B, Meisel ZF. Evid Policy2023 Nov19(4):554-571http://www.ncbi.nlm.nih.gov/pubmed/37355639"I wouldn't need Narcan for myself, but I can have it for somebody else:" perceptions of harm reduction among hospitalized patients with OUD. Addict Sci Clin Pract. 2023 06 24; 18(1):41.French R, Holliday Davis M, Aronowitz SV, Crowe M, Abrams M, Edwards G, Lowenstein M. Addict Sci Clin Pract2023 06 2418(1):41http://www.ncbi.nlm.nih.gov/pubmed/37318805Thematic Analysis of State Medicaid Buprenorphine Prior Authorization Requirements. JAMA Netw Open. 2023 06 01; 6(6):e2318487.Nguemeni Tiako MJ, Dolan A, Abrams M, Oyekanmi K, Meisel Z, Aronowitz SV. JAMA Netw Open2023 06 016(6):e2318487http://www.ncbi.nlm.nih.gov/pubmed/37207615"Come try it out. Get your foot in the door:" Exploring patient perspectives on low-barrier treatment for opioid use disorder. Drug Alcohol Depend. 2023 07 01; 248:109915.Lowenstein M, Abrams MP, Crowe M, Shimamoto K, Mazzella S, Botcheos D, Bertocchi J, Westfahl S, Chertok J, Garcia KP, Truchil R, Holliday-Davis M, Aronowitz S. Drug Alcohol Depend2023 07 01248:109915http://www.ncbi.nlm.nih.gov/pubmed/36906576"The new normal has become a nonstop crisis": a qualitative study of burnout among Philadelphia's harm reduction and substance use disorder treatment workers during the COVID-19 pandemic. Harm Reduct J. 2023 03 11; 20(1):32.Unachukwu IC, Abrams MP, Dolan A, Oyekemi K, Meisel ZF, South EC, Aronowitz SV. Harm Reduct J2023 03 1120(1):32http://www.ncbi.nlm.nih.gov/pubmed/36895704On, With, By-Advancing Transgender Health Research and Clinical Practice. Health Equity. 2023; 7(1):161-165.Streed CG, Perlson JE, Abrams MP, Lett E. Health Equity20237(1):161-165http://www.ncbi.nlm.nih.gov/pubmed/37013000State and Federal Legislators' Responses on Social Media to the Mental Health and Burnout of Health Care Workers Throughout the COVID-19 Pandemic: Natural Language Processing and Sentiment Analysis. JMIR Infodemiology. 2023; 3:e38676.Abrams MP, Pelullo AP, Meisel ZF, Merchant RM, Purtle J, Agarwal AK. JMIR Infodemiology20233:e38676http://www.ncbi.nlm.nih.gov/pubmed/35962805Syndemic relationship of depressive symptoms, substance use, and suicidality in transgender youth: a cross-sectional study using the U.S. youth risk behavior surveillance system. Soc Psychiatry Psychiatr Epidemiol. 2022 Nov; 57(11):2293-2304.Lett E, Abrams MP, Moberg E, Benson GP, Perlson JE. Soc Psychiatry Psychiatr Epidemiol2022 Nov57(11):2293-2304http://www.ncbi.nlm.nih.gov/pubmed/35980634Patient Perceptions About Opioid Risk Communications Within the Context of a Randomized Clinical Trial. JAMA Netw Open. 2022 08 01; 5(8):e2227650.Dolan AR, Goldberg EB, Cannuscio CC, Abrams MP, Feuerstein-Simon R, Luna Marti X, Mazique J, Schapira MM, Meisel ZF. JAMA Netw Open2022 08 015(8):e2227650http://www.ncbi.nlm.nih.gov/pubmed/35564535Impact of Providing Peer Support on Medical Students' Empathy, Self-Efficacy, and Mental Health Stigma. Int J Environ Res Public Health. 2022 04 23; 19(9).Abrams MP, Salzman J, Espina Rey A, Daly K. Int J Environ Res Public Health2022 04 2319(9)http://www.ncbi.nlm.nih.gov/pubmed/35286878Excise and Ionize. Int J Radiat Oncol Biol Phys. 2022 04 01; 112(5):1073-1074.Chapman TR, Abrams MJ. Int J Radiat Oncol Biol Phys2022 04 01112(5):1073-1074http://www.ncbi.nlm.nih.gov/pubmed/35288865Aligning Medical Student Workplace-Based Assessments with Entrustable Professional Activities and the RIME Model in a Psychiatry Clerkship. Acad Psychiatry. 2022 Jun; 46(3):283-288.Klapheke M, Abrams MP, Cubero M, Zhu X. Acad Psychiatry2022 Jun46(3):283-288http://www.ncbi.nlm.nih.gov/pubmed/35137246Ethnoracial inequities in access to gender-affirming mental health care and psychological distress among transgender adults. Soc Psychiatry Psychiatr Epidemiol. 2022 May; 57(5):963-971.Lett E, Abrams MP, Gold A, Fullerton FA, Everhart A. Soc Psychiatry Psychiatr Epidemiol2022 May57(5):963-971http://www.ncbi.nlm.nih.gov/pubmed/36044555Evaluating ACGME-accredited addiction psychiatry fellowship online content: A critical analysis of addiction psychiatry fellowship program websites in the US. Subst Abus. 2022; 43(1):1346-1352.Abrams MP, Lett E, Jackson DS, Kohler AE, Jordan A. Subst Abus202243(1):1346-1352http://www.ncbi.nlm.nih.gov/pubmed/35142262Perceptions on navigating ACGME-accredited addiction psychiatry fellowship program websites: A thematic analysis across a race- and gender-diverse pool of potential applicants. Subst Abus. 2022; 43(1):834-840.Abrams MP, Jackson DS, Aneke-Gratia A, Kohler AE, Mehtani N, Jordan A. Subst Abus202243(1):834-840http://www.ncbi.nlm.nih.gov/pubmed/34409581A Call for Reform: Variability and Insufficiency in Radiation Oncology Resident Didactics-a Brief Report and National Survey of Program Directors. J Cancer Educ. 2023 02; 38(1):74-77.Abrams MJ, Golden DW, Huang GC. J Cancer Educ2023 0238(1):74-77http://www.ncbi.nlm.nih.gov/pubmed/33955406Omission of or Poor Response to Preoperative Chemoradiotherapy Impacts Radial Margin Positivity Rates in Locally Advanced Rectal Cancer. Dis Colon Rectum. 2021 06 01; 64(6):669-676.Ore AS, Dombek GE, Cordova-Cassia CA, Quinn JF, Cataldo TE, Schlechter BL, Abrams MJ, Messaris E. Dis Colon Rectum2021 06 0164(6):669-676http://www.ncbi.nlm.nih.gov/pubmed/32767155Biometric Registration to an HIV Research Study may Deter Participation. AIDS Behav. 2021 May; 25(5):1552-1559.Abrams MP, Torres FE, Little SJ. AIDS Behav2021 May25(5):1552-1559SBRT re-irradiation after prior SBRT in pancreatic cancer—outcomes and a focus on stomach and bowel toxicity. Journal of Radiation Oncology. 2020; 9(3):235–241.Duran JF, Hurwitz M, Chapman T, Abrams, MJ. Journal of Radiation Oncology20209(3):235–241http://www.ncbi.nlm.nih.gov/pubmed/33052018Reflective Writing on the Cadaveric Dissection Experience: An Effective Tool to Assess the Impact of Dissection on Learning of Anatomy, Humanism, Empathy, Well-Being, and Professional Identity Formation in Medical Students. Anat Sci Educ. 2021 Sep; 14(5):658-665.Abrams MP, Eckert T, Topping D, Daly KD. Anat Sci Educ2021 Sep14(5):658-665http://www.ncbi.nlm.nih.gov/pubmed/32270414Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. Protein J. 2020 06; 39(3):232-239.Deiktakis EE, Abrams M, Tsapara A, Stournaras C, Tsatsanis C, Tsichlis PN, Kampranis SC. Protein J2020 0639(3):232-239http://www.ncbi.nlm.nih.gov/pubmed/29623563Assessment of Radiology Training During Radiation Oncology Residency. J Cancer Educ. 2019 Aug; 34(4):691-695.Matalon SA, Howard SA, Abrams MJ. J Cancer Educ2019 Aug34(4):691-695http://www.ncbi.nlm.nih.gov/pubmed/28463158Postmastectomy Radiation Therapy Is Associated With Improved Survival in Node-Positive Male Breast Cancer: A Population Analysis. Int J Radiat Oncol Biol Phys. 2017 06 01; 98(2):384-391.Abrams MJ, Koffer PP, Wazer DE, Hepel JT. Int J Radiat Oncol Biol Phys2017 06 0198(2):384-391http://www.ncbi.nlm.nih.gov/pubmed/27069148The Emerging Non-operative Management of Non-metastatic Rectal Cancer: A Population Analysis. Anticancer Res. 2016 Apr; 36(4):1699-702.Abrams MJ, Koffer PP, Leonard KL. Anticancer Res2016 Apr36(4):1699-702http://www.ncbi.nlm.nih.gov/pubmed/26929776Recent advances in pancreatic cancer: updates and insights from the 2015 annual meeting of the American Society of Clinical Oncology. Therap Adv Gastroenterol. 2016 Mar; 9(2):141-51.Abrams MJ, Rakszawski K, Vasekar M, Passero F, Abbas A, Jia Y, Saif MW. Therap Adv Gastroenterol2016 Mar9(2):141-51http://www.ncbi.nlm.nih.gov/pubmed/26846381Brachytherapy vs. external beam radiotherapy for choroidal melanoma: Survival and patterns-of-care analyses. Brachytherapy. 2016 Mar-Apr; 15(2):216-23.Abrams MJ, Gagne NL, Melhus CS, Mignano JE. Brachytherapy2016 Mar-Apr15(2):216-23http://www.ncbi.nlm.nih.gov/pubmed/26637914Capecitabine as a Radiosensitizer in Adjuvant Chemoradiotherapy for Pancreatic Cancer: A Retrospective Study. Anticancer Res. 2015 Dec; 35(12):6901-7.Abrams MJ, Huber KE, Knisely JP, Chang BW, Russo SM, Saif MW. Anticancer Res2015 Dec35(12):6901-7http://www.ncbi.nlm.nih.gov/pubmed/14728210Creating a virtual community of learning predicated on medical student learning styles. AMIA Annu Symp Proc. 2003; 435-44.McGowan J, Abrams M, Frank M, Bangert M. AMIA Annu Symp Proc2003435-44http://www.ncbi.nlm.nih.gov/pubmed/2208163Cytotoxicity, radiosensitization, antitumor activity, and interaction with hyperthermia of a Co(III) mustard complex. Cancer Res. 1990 Nov 01; 50(21):6971-5.Teicher BA, Abrams MJ, Rosbe KW, Herman TS. Cancer Res1990 Nov 0150(21):6971-5Radiation Oncology41.538295541962962e+0002019-08-01T00:00:002024-12-27T00:00:00Addiction Medicine21.411580437911135e+0002022-01-01T00:00:002022-01-01T00:00:00Education, Medical, Undergraduate61.125133281306880e+0002003-01-01T00:00:002024-12-27T00:00:00Students, Medical78.747209812607086e-0012003-01-01T00:00:002024-12-27T00:00:00Clinical Clerkship38.300131398842870e-0012022-03-14T00:00:002024-12-27T00:00:00Internship and Residency56.743166071610506e-0012019-08-01T00:00:002024-07-11T00:00:00Radiation Oncologists15.841358548605617e-0012019-08-01T00:00:002019-08-01T00:00:00Anatomy15.757004293106598e-0012020-11-13T00:00:002020-11-13T00:00:00Curriculum75.517956731133556e-0012003-01-01T00:00:002024-12-27T00:00:00Commerce14.788093814213802e-0012022-04-01T00:00:002022-04-01T00:00:00Breast Neoplasms, Male14.412660531546188e-0012017-02-13T00:00:002017-02-13T00:00:00Choroid Neoplasms14.408817761649190e-0012016-02-01T00:00:002016-02-01T00:00:00Capecitabine14.233362722505251e-0012015-12-01T00:00:002015-12-01T00:00:00Radiation-Sensitizing Agents24.207029519059239e-0011990-11-01T00:00:002015-12-01T00:00:00Carcinoma, Lobular13.928012853921490e-0012017-02-13T00:00:002017-02-13T00:00:00Educational Measurement23.872071280795462e-0012019-08-01T00:00:002022-03-14T00:00:00Rectal Neoplasms23.485092442301925e-0012016-04-01T00:00:002021-06-01T00:00:00Carcinoma, Ductal, Breast13.155246366661783e-0012017-02-13T00:00:002017-02-13T00:00:00Empathy32.821893258405510e-0012020-11-13T00:00:002025-02-03T00:00:00Opioid-Related Disorders42.813041249510400e-0012023-05-09T00:00:002025-02-03T00:00:00Brachytherapy12.774916631769003e-0012016-02-01T00:00:002016-02-01T00:00:00SEER Program32.514133709524118e-0012016-02-01T00:00:002017-02-13T00:00:00Radiology12.313021652261410e-0012019-08-01T00:00:002019-08-01T00:00:00Smoking12.303841823531211e-0012022-04-01T00:00:002022-04-01T00:00:00Lymph Nodes12.269327166389358e-0012017-02-13T00:00:002017-02-13T00:00:00Buprenorphine22.227583070056539e-0012023-05-09T00:00:002023-06-01T00:00:00Education, Medical, Graduate32.213324223517248e-0012021-08-18T00:00:002022-01-01T00:00:00Clinical Competence22.096419322006992e-0012019-08-01T00:00:002022-03-14T00:00:00Pancreatic Neoplasms21.970614500064256e-0012015-12-01T00:00:002025-06-19T00:00:00Fellowships and Scholarships21.897594688473070e-0012022-01-01T00:00:002022-01-01T00:00:00Radiotherapy, Adjuvant21.733088127605605e-0012016-04-01T00:00:002017-02-13T00:00:00Naloxone11.634961497267665e-0012023-06-24T00:00:002023-06-24T00:00:00ADP-Ribosylation Factor 111.623970423535897e-0012020-06-01T00:00:002020-06-01T00:00:00Cyclin-Dependent Kinase Inhibitor p1511.601162925545684e-0012020-06-01T00:00:002020-06-01T00:00:00Transgender Persons21.600298162219832e-0012022-02-08T00:00:002022-08-13T00:00:00Proctectomy11.593017699997287e-0012021-06-01T00:00:002021-06-01T00:00:00Humanism11.581537781571565e-0012020-11-13T00:00:002020-11-13T00:00:00Delphi Technique11.564004904492755e-0012024-12-27T00:00:002024-12-27T00:00:00Internet21.508793331264598e-0012022-01-01T00:00:002022-01-01T00:00:00Acute Pain11.488495361317509e-0012022-08-01T00:00:002022-08-01T00:00:00Jumonji Domain-Containing Histone Demethylases11.467271802742460e-0012020-06-01T00:00:002020-06-01T00:00:00Risk-Taking21.463739957873129e-0012021-05-01T00:00:002022-08-13T00:00:00Dissection11.460098686489029e-0012020-11-13T00:00:002020-11-13T00:00:00Writing11.418346550855381e-0012020-11-13T00:00:002020-11-13T00:00:00F-Box Proteins11.405485495359143e-0012020-06-01T00:00:002020-06-01T00:00:00Accreditation11.385307015538705e-0012022-01-01T00:00:002022-01-01T00:00:00Qualitative Research31.372262328632022e-0012023-06-24T00:00:002025-02-03T00:00:00Biometry11.343008739625755e-0012021-05-01T00:00:002021-05-01T00:00:00Self Efficacy11.307188009082096e-0012022-04-23T00:00:002022-04-23T00:00:00Surveys and Questionnaires41.301877023498674e-0012019-08-01T00:00:002024-12-27T00:00:00Neoadjuvant Therapy21.298297240302350e-0012016-04-01T00:00:002021-06-01T00:00:00Harm Reduction31.286844510986649e-0012023-03-11T00:00:002023-06-24T00:00:00Mastectomy, Modified Radical11.278820789682741e-0012017-02-13T00:00:002017-02-13T00:00:00Melanoma11.270584810788153e-0012016-02-01T00:00:002016-02-01T00:00:00Cyclin-Dependent Kinase Inhibitor p1611.242605534960000e-0012020-06-01T00:00:002020-06-01T00:00:00Humans281.231315590710446e-0011990-11-01T00:00:002025-06-19T00:00:00Patient Preference11.227603930746301e-0012025-02-03T00:00:002025-02-03T00:00:00Cadaver11.219688301150252e-0012020-11-13T00:00:002020-11-13T00:00:00Kaplan-Meier Estimate21.191730002164626e-0012016-02-01T00:00:002017-02-13T00:00:00Substance-Related Disorders21.186634242504464e-0012022-08-13T00:00:002023-03-11T00:00:00Psychological Distress11.113538733573608e-0012022-02-08T00:00:002022-02-08T00:00:00Radiosurgery11.110072936838354e-0012025-06-19T00:00:002025-06-19T00:00:00Social Stigma11.099651054430738e-0012022-04-23T00:00:002022-04-23T00:00:00HIV Infections11.069704959707379e-0012021-05-01T00:00:002021-05-01T00:00:00Burnout, Professional11.047445368119222e-0012023-03-11T00:00:002023-03-11T00:00:00Adenocarcinoma21.030732211552991e-0012016-04-01T00:00:002025-06-19T00:00:00Cellular Senescence11.021200618315849e-0012020-06-01T00:00:002020-06-01T00:00:00Neoplasm Staging39.924622609735030e-0022015-12-01T00:00:002021-06-01T00:00:00Adaptation, Psychological19.795083365429444e-0022024-07-11T00:00:002024-07-11T00:00:00Inpatients19.788301743728219e-0022025-02-03T00:00:002025-02-03T00:00:00Chemoradiotherapy, Adjuvant19.704438664854576e-0022015-12-01T00:00:002015-12-01T00:00:00Cross-Sectional Studies49.478237046944861e-0022020-11-13T00:00:002022-08-13T00:00:00Communication29.456741911875241e-0022022-08-01T00:00:002025-02-03T00:00:00Philadelphia29.344935662975304e-0022023-03-11T00:00:002023-05-09T00:00:00Postoperative Period19.081041752281593e-0022017-02-13T00:00:002017-02-13T00:00:00Receptors, Progesterone19.058231616528364e-0022017-02-13T00:00:002017-02-13T00:00:00Homosexuality, Male18.884114360597649e-0022021-05-01T00:00:002021-05-01T00:00:00Survival Rate28.805490284831502e-0022015-12-01T00:00:002016-02-01T00:00:00Preoperative Care18.756641378626644e-0022021-06-01T00:00:002021-06-01T00:00:00Suicide18.648347948968536e-0022022-08-13T00:00:002022-08-13T00:00:00Combined Modality Therapy38.339893480672339e-0021990-11-01T00:00:002025-06-19T00:00:00Male158.227439745099240e-0021990-11-01T00:00:002025-06-19T00:00:00Remission Induction18.017745616197179e-0022016-04-01T00:00:002016-04-01T00:00:00Mental Health27.882524064869327e-0022022-02-08T00:00:002022-04-23T00:00:00Psychiatry17.837143457007376e-0022022-03-14T00:00:002022-03-14T00:00:00Analgesics, Opioid27.576438705506866e-0022022-08-01T00:00:002023-05-09T00:00:00Chemoradiotherapy17.278679012823928e-0022016-04-01T00:00:002016-04-01T00:00:00Analysis of Variance17.239054031100770e-0022017-02-13T00:00:002017-02-13T00:00:00Receptors, Estrogen17.177755346857333e-0022017-02-13T00:00:002017-02-13T00:00:00Hospitalization26.676399644012225e-0022023-06-24T00:00:002025-02-03T00:00:00DNA16.223862246846804e-0022020-06-01T00:00:002020-06-01T00:00:00Aged76.195924943038513e-0022015-12-01T00:00:002025-06-19T00:00:00Adult75.825132326600349e-0022016-02-01T00:00:002025-02-03T00:00:00Mass Screening15.512206987782651e-0022021-05-01T00:00:002021-05-01T00:00:00Neoplasm Metastasis15.488878794922133e-0022015-12-01T00:00:002015-12-01T00:00:00Survival Analysis15.426476222821450e-0022017-02-13T00:00:002017-02-13T00:00:00United States65.345502124678027e-0022003-01-01T00:00:002024-07-11T00:00:00Female115.071667173738129e-0022016-02-01T00:00:002025-06-19T00:00:00Middle Aged74.965649421949651e-0022016-02-01T00:00:002025-06-19T00:00:00Prior Authorization14.725830457704536e-0022023-06-01T00:00:002023-06-01T00:00:00Buprenorphine, Naloxone Drug Combination14.630221500223573e-0022023-06-01T00:00:002023-06-01T00:00:00Syndemic14.475145680616085e-0022022-08-13T00:00:002022-08-13T00:00:00Retrospective Studies44.469633519550877e-0022015-12-01T00:00:002025-06-19T00:00:00Tomography, X-Ray Computed14.432519309631437e-0022025-06-19T00:00:002025-06-19T00:00:00Young Adult34.290765064663413e-0022016-02-01T00:00:002022-02-08T00:00:00Decision Making, Shared14.184309380225207e-0022025-02-03T00:00:002025-02-03T00:00:00Data Management14.030272558465791e-0022021-06-01T00:00:002021-06-01T00:00:00Competency-Based Education13.915246741610772e-0022022-03-14T00:00:002022-03-14T00:00:00Computer-Assisted Instruction13.901166428828964e-0022003-01-01T00:00:002003-01-01T00:00:00Age Factors13.722012480734283e-0022016-02-01T00:00:002016-02-01T00:00:00Primary Cell Culture13.470060049858924e-0022020-06-01T00:00:002020-06-01T00:00:00Protein Interaction Domains and Motifs13.441984676114384e-0022020-06-01T00:00:002020-06-01T00:00:00Opiate Substitution Treatment13.393853119557035e-0022023-05-09T00:00:002023-05-09T00:00:00Margins of Excision13.345518281286136e-0022021-06-01T00:00:002021-06-01T00:00:00Neoplasm Recurrence, Local13.167359139374403e-0022015-12-01T00:00:002015-12-01T00:00:00Gender Identity12.960794899813300e-0022022-02-08T00:00:002022-02-08T00:00:00Informed Consent12.936449224457216e-0022022-08-01T00:00:002022-08-01T00:00:00Educational Status12.928869541692379e-0022023-07-19T00:00:002023-07-19T00:00:00Interdisciplinary Communication12.923365584688778e-0022021-06-01T00:00:002021-06-01T00:00:00Workplace12.893737401982399e-0022022-03-14T00:00:002022-03-14T00:00:00CpG Islands12.850537480180190e-0022020-06-01T00:00:002020-06-01T00:00:00Point Mutation12.824875076733794e-0022020-06-01T00:00:002020-06-01T00:00:00Embryo, Mammalian12.703725931461775e-0022020-06-01T00:00:002020-06-01T00:00:00Follow-Up Studies12.672978579032982e-0022016-04-01T00:00:002016-04-01T00:00:00Learning12.455114993755744e-0022003-01-01T00:00:002003-01-01T00:00:00COVID-1912.384917830029566e-0022023-03-11T00:00:002023-03-11T00:00:00Regression Analysis12.266107655630396e-0022021-06-01T00:00:002021-06-01T00:00:00Binding Sites12.215180172770837e-0022020-06-01T00:00:002020-06-01T00:00:00Suicidal Ideation12.204063182291602e-0022022-08-13T00:00:002022-08-13T00:00:00Aged, 80 and over12.129139748974155e-0022017-02-13T00:00:002017-02-13T00:00:00Pain Management11.999893829295190e-0022022-08-01T00:00:002022-08-01T00:00:00Medicaid11.907362737443902e-0022023-06-01T00:00:002023-06-01T00:00:00Fibroblasts11.897949318448765e-0022020-06-01T00:00:002020-06-01T00:00:00Treatment Outcome11.834685826345061e-0022016-04-01T00:00:002016-04-01T00:00:00Health Personnel11.795672893113208e-0022023-03-11T00:00:002023-03-11T00:00:00Software11.783225681248579e-0022003-01-01T00:00:002003-01-01T00:00:00Protein Binding11.708307817511860e-0022020-06-01T00:00:002020-06-01T00:00:00Hyperthermia, Induced11.597197724514940e-0021990-11-01T00:00:001990-11-01T00:00:00Outcome Assessment, Health Care11.488615665909406e-0022021-06-01T00:00:002021-06-01T00:00:00Health Services Accessibility11.398660484666323e-0022023-05-09T00:00:002023-05-09T00:00:00Medicare11.364759340057659e-0022023-06-01T00:00:002023-06-01T00:00:00Adolescent21.249671185929049e-0022022-02-08T00:00:002022-08-13T00:00:00Pandemics11.231750723444471e-0022023-03-11T00:00:002023-03-11T00:00:00Severity of Illness Index11.229999357161540e-0022021-06-01T00:00:002021-06-01T00:00:00Indiana11.209018691040254e-0022003-01-01T00:00:002003-01-01T00:00:00Gene Expression Regulation11.172714813377684e-0022020-06-01T00:00:002020-06-01T00:00:00Cell Differentiation11.166725786450975e-0022020-06-01T00:00:002020-06-01T00:00:00Audiovisual Aids11.135725071531831e-0022003-01-01T00:00:002003-01-01T00:00:00Depression11.135397213328663e-0022022-08-13T00:00:002022-08-13T00:00:00Computer Systems11.077791282565997e-0022003-01-01T00:00:002003-01-01T00:00:00Problem-Based Learning19.289994749067424e-0032003-01-01T00:00:002003-01-01T00:00:00Cohort Studies18.797286096083826e-0032021-06-01T00:00:002021-06-01T00:00:00Postoperative Complications18.588627296592695e-0032021-06-01T00:00:002021-06-01T00:00:00Costs and Cost Analysis18.081753753510156e-0032003-01-01T00:00:002003-01-01T00:00:00Signal Transduction17.979373219593307e-0032020-06-01T00:00:002020-06-01T00:00:00Schools, Medical17.542540782426802e-0032003-01-01T00:00:002003-01-01T00:00:00History, 20th Century17.030976005681097e-0032003-01-01T00:00:002003-01-01T00:00:00Mice26.774266380667504e-0031990-11-01T00:00:002020-06-01T00:00:00Leukemia L121015.325864952852598e-0031990-11-01T00:00:001990-11-01T00:00:00Pentanones15.324851308848817e-0031990-11-01T00:00:001990-11-01T00:00:00Cobalt15.106293553088494e-0031990-11-01T00:00:001990-11-01T00:00:00Animals24.829219183048056e-0031990-11-01T00:00:002020-06-01T00:00:00Fibrosarcoma14.483976066737182e-0031990-11-01T00:00:001990-11-01T00:00:00Mice, Inbred Strains14.340934095334355e-0031990-11-01T00:00:001990-11-01T00:00:00Antineoplastic Agents14.210951338622704e-0031990-11-01T00:00:001990-11-01T00:00:00Neoplasm Transplantation14.018155964561472e-0031990-11-01T00:00:001990-11-01T00:00:00Organometallic Compounds13.906784238294285e-0031990-11-01T00:00:001990-11-01T00:00:00Cell Survival12.619663316223638e-0031990-11-01T00:00:001990-11-01T00:00:00Carcinoma, Squamous Cell11.759271565590919e-0031990-11-01T00:00:001990-11-01T00:00:00Jose A. Abrego, M.D.JoseAbrego

1000 Broadway Chelsea, MA 02150617/975-620042.40280000000000-71.02020000000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineApgAssistant Professor of Medicine, Part-timeAssistant Professorhttp://www.ncbi.nlm.nih.gov/pubmed/22490662Structural insights into selectivity and cofactor binding in snake venom L-amino acid oxidases. Biochem Biophys Res Commun. 2012 Apr 27; 421(1):124-8.Ullah A, Souza TA, Abrego JR, Betzel C, Murakami MT, Arni RK. Biochem Biophys Res Commun2012 Apr 27421(1):124-8http://www.ncbi.nlm.nih.gov/pubmed/18384085Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis. Proteins. 2008 Sep; 72(4):1352-62.Vivan AL, Caceres RA, Abrego JR, Borges JC, Ruggiero Neto J, Ramos CH, de Azevedo WF, Basso LA, Santos DS. Proteins2008 Sep72(4):1352-62Bothrops19.433390277782450e-0022012-04-03T00:00:002012-04-03T00:00:00L-Amino Acid Oxidase19.430416255897264e-0022012-04-03T00:00:002012-04-03T00:00:00Crotalid Venoms19.313650104829084e-0022012-04-03T00:00:002012-04-03T00:00:00Prephenate Dehydratase17.357049245907846e-0022008-09-01T00:00:002008-09-01T00:00:00Models, Molecular13.534439616269826e-0022008-09-01T00:00:002008-09-01T00:00:00Protein Structure, Secondary23.294902169815059e-0022008-09-01T00:00:002012-04-03T00:00:00Mycobacterium tuberculosis13.200512301138056e-0022008-09-01T00:00:002008-09-01T00:00:00Computer Simulation12.778672798437142e-0022008-09-01T00:00:002008-09-01T00:00:00Enzyme Stability12.243953229069634e-0022012-04-03T00:00:002012-04-03T00:00:00Hydrophobic and Hydrophilic Interactions12.091863900168417e-0022012-04-03T00:00:002012-04-03T00:00:00Scattering, Small Angle11.803470024935052e-0022008-09-01T00:00:002008-09-01T00:00:00Ultracentrifugation11.790369500009160e-0022008-09-01T00:00:002008-09-01T00:00:00X-Ray Diffraction11.738870335502220e-0022008-09-01T00:00:002008-09-01T00:00:00Crystallography, X-Ray11.660830024681141e-0022012-04-03T00:00:002012-04-03T00:00:00Amino Acid Sequence11.039592799525686e-0022012-04-03T00:00:002012-04-03T00:00:00Molecular Sequence Data19.747113364244752e-0032012-04-03T00:00:002012-04-03T00:00:00Recombinant Proteins19.202552097660586e-0032008-09-01T00:00:002008-09-01T00:00:00Animals12.430094415418827e-0032012-04-03T00:00:002012-04-03T00:00:00Devon Abt, M.D.DevonAbt

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterObstetrics Gynecology & Repro. Bio.Clinical Fellow in Obstetrics, Gynecology and Reproductive BiologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/35868657Endometrial stripe thickness: a preoperative marker to identify patients with endometrial intraepithelial neoplasia who may benefit from sentinel lymph node mapping and biopsy. Int J Gynecol Cancer. 2022 Sep 06; 32(9):1091-1097.Abt D, Macharia A, Hacker MR, Baig R, Esselen KM, Ducie J. Int J Gynecol Cancer2022 Sep 0632(9):1091-1097http://www.ncbi.nlm.nih.gov/pubmed/33262212An Antepartum Emergency. Neoreviews. 2020 12; 21(12):e838-e843.Abt D, Golen T. Neoreviews2020 1221(12):e838-e843Cesarean Section13.709624732613533e-0012020-12-01T00:00:002020-12-01T00:00:00Pregnancy13.614063838504800e-0022020-12-01T00:00:002020-12-01T00:00:00Female11.070861482597001e-0022020-12-01T00:00:002020-12-01T00:00:00Humans17.447751654606250e-0032020-12-01T00:00:002020-12-01T00:00:00Pooja Marella Achanta, D.M.PoojaAchanta

Beth Israel Deaconess Medical CenterDivision: Adm-House Staff330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterMedicineAdm-House StaffClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/40925523Addition of dupilumab for patients with aspirin-exacerbated respiratory disease who have poor response to aspirin therapy after desensitization. J Allergy Clin Immunol Pract. 2025 Dec; 13(12):3425-3427.e1.Achanta PM, Swirnoff J, Parigian RE, Laidlaw TM, Buchheit KM. J Allergy Clin Immunol Pract2025 Dec13(12):3425-3427.e1http://www.ncbi.nlm.nih.gov/pubmed/40256967Ageism in Rheumatology: The Health Care Professional's Perspective. Arthritis Care Res (Hoboken). 2025 Oct; 77(10):1254-1262.Smith AP, Achanta PM, Lee J, Singh N, Makris UE. Arthritis Care Res (Hoboken)2025 Oct77(10):1254-1262Rheumatologists12.250315337124419e-0012025-06-23T00:00:002025-06-23T00:00:00Ageism12.216174509901294e-0012025-06-23T00:00:002025-06-23T00:00:00Rheumatology11.490856607236581e-0012025-06-23T00:00:002025-06-23T00:00:00Rheumatic Diseases11.410170234263402e-0012025-06-23T00:00:002025-06-23T00:00:00Health Personnel18.416002351292819e-0022025-06-23T00:00:002025-06-23T00:00:00Attitude of Health Personnel18.184232787249487e-0022025-06-23T00:00:002025-06-23T00:00:00Stereotyping14.911662009034543e-0022025-06-23T00:00:002025-06-23T00:00:00Age Factors11.784061950753578e-0022025-06-23T00:00:002025-06-23T00:00:00Surveys and Questionnaires11.244136608339803e-0022025-06-23T00:00:002025-06-23T00:00:00Aged15.571646732156451e-0032025-06-23T00:00:002025-06-23T00:00:00Adult14.987320251351978e-0032025-06-23T00:00:002025-06-23T00:00:00Middle Aged14.986988262871845e-0032025-06-23T00:00:002025-06-23T00:00:00Male13.879617081749731e-0032025-06-23T00:00:002025-06-23T00:00:00Female13.671964544430412e-0032025-06-23T00:00:002025-06-23T00:00:00Humans12.553820494609102e-0032025-06-23T00:00:002025-06-23T00:00:00Omeralfaroug Adam, M.D.OmeralfarougAdam

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/40975149Learning curve and procedural efficiency of zero-fluoroscopy pulsed-field ablation for atrial fibrillation. Heart Rhythm. 2025 Sep 18.Pérez-Pinzón J, Villarreal D, Ma M, Clarke JR, Ferro EG, Modi R, Adam O, Isaza N, Odozynski G, Samra G, Yopes M, Saad EB, Zimetbaum P, Haffajee CI, Yang S, Maher T, Kumar K, Shvilkin A, d'Avila A, Michaud GF, Tung P, Waks JW, Locke AH. Heart Rhythm2025 Sep 18Sophia Adamia, Ph.D.SophiaAdamia

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/632-6083

1BIDMCBeth Israel Deaconess Medical CenterMedicineHematology/OncologyInstructor in MedicineInstructorhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=208516431http://www.ncbi.nlm.nih.gov/pubmed/38442309Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood Cancer Discov. 2024 May 01; 5(3):180-201.Olesinski EA, Bhatia KS, Wang C, Pioso MS, Lin XX, Mamdouh AM, Ng SX, Sandhu V, Jasdanwala SS, Yilma B, Bohl S, Ryan JA, Malani D, Luskin MR, Kallioniemi O, Porkka K, Adamia S, Chng WJ, Osato M, Weinstock DM, Garcia JS, Letai A, Bhatt S. Blood Cancer Discov2024 May 015(3):180-201http://www.ncbi.nlm.nih.gov/pubmed/36737429Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics. Blood Cancer J. 2023 02 03; 13(1):23.Ogiya D, Chyra Z, Verselis SJ, O'Keefe M, Cobb J, Abiatari I, Talluri S, Sithara AA, Hideshima T, Chu MP, Hájek R, Dorfman DM, Pilarski LM, Anderson KC, Adamia S. Blood Cancer J2023 02 0313(1):23http://www.ncbi.nlm.nih.gov/pubmed/35513704Author Correction: Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma. Leukemia. 2022 Jun; 36(6):1700.Adamia S, Bhatt S, Wen K, Chyra Z, Fell GG, Tai YT, Pioso MS, Abiatari I, Letai A, Dorfman DM, Hideshima T, Anderson KC. Leukemia2022 Jun36(6):1700http://www.ncbi.nlm.nih.gov/pubmed/35082402Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma. Leukemia. 2022 04; 36(4):1088-1101.Adamia S, Bhatt S, Wen K, Chyra Z, Fell GG, Tai YT, Pioso MS, Abiatari I, Letai A, Dorfman DM, Hideshima T, Anderson KC. Leukemia2022 0436(4):1088-1101http://www.ncbi.nlm.nih.gov/pubmed/33217342Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Cell. 2020 12 14; 38(6):872-890.e6.Bhatt S, Pioso MS, Olesinski EA, Yilma B, Ryan JA, Mashaka T, Leutz B, Adamia S, Zhu H, Kuang Y, Mogili A, Louissaint A, Bohl SR, Kim AS, Mehta AK, Sanghavi S, Wang Y, Morris E, Halilovic E, Paweletz CP, Weinstock DM, Garcia JS, Letai A. Cancer Cell2020 12 1438(6):872-890.e6http://www.ncbi.nlm.nih.gov/pubmed/32844992The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications. Blood. 2020 11 12; 136(20):2334-2345.Ogiya D, Liu J, Ohguchi H, Kurata K, Samur MK, Tai YT, Adamia S, Ando K, Hideshima T, Anderson KC. Blood2020 11 12136(20):2334-2345http://www.ncbi.nlm.nih.gov/pubmed/32144400Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia. Leukemia. 2020 Sep; 34(9):2543.Weisberg E, Meng C, Case A, Sattler M, Tiv HL, Gokhale PC, Buhrlage S, Wang J, Gray N, Stone R, Liu S, Bhagwat SV, Tiu RV, Adamia S, Griffin JD. Leukemia2020 Sep34(9):2543http://www.ncbi.nlm.nih.gov/pubmed/32015510Inhibition of the deubiquitinase USP10 induces degradation of SYK. Br J Cancer. 2020 04; 122(8):1175-1184.Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin RS, Adamia S, Wang J, Gray N, Liu S, Stone R, Sattler M, Buhrlage S, Griffin JD. Br J Cancer2020 04122(8):1175-1184http://www.ncbi.nlm.nih.gov/pubmed/31967735Effects of the multi-kinase inhibitor midostaurin in combination with chemotherapy in models of acute myeloid leukaemia. J Cell Mol Med. 2020 03; 24(5):2968-2980.Weisberg E, Meng C, Case AE, Tiv HL, Gokhale PC, Buhrlage SJ, Yang J, Liu X, Wang J, Gray N, Adamia S, Sattler M, Stone R, Griffin JD. J Cell Mol Med2020 0324(5):2968-2980http://www.ncbi.nlm.nih.gov/pubmed/31943762The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations. J Cell Mol Med. 2020 02; 24(3):2145-2156.Weisberg E, Meng C, Case AE, Tiv HL, Gokhale PC, Toure AA, Buhrlage S, Liu X, Wang J, Gray N, Stone R, Adamia S, Winer E, Sattler M, Griffin JD. J Cell Mol Med2020 0224(3):2145-2156http://www.ncbi.nlm.nih.gov/pubmed/31455850Evaluation of ERK as a therapeutic target in acute myelogenous leukemia. Leukemia. 2020 02; 34(2):625-629.Weisberg E, Meng C, Case A, Sattler M, Tiv HL, Gokhale PC, Buhrlage S, Wang J, Gray N, Stone R, Liu S, Bhagwat SV, Tiu RV, Adamia S, Griffin JD. Leukemia2020 0234(2):625-629http://www.ncbi.nlm.nih.gov/pubmed/31309543Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies. Br J Haematol. 2019 11; 187(4):488-501.Weisberg E, Meng C, Case AE, Sattler M, Tiv HL, Gokhale PC, Buhrlage SJ, Liu X, Yang J, Wang J, Gray N, Stone RM, Adamia S, Dubreuil P, Letard S, Griffin JD. Br J Haematol2019 11187(4):488-501http://www.ncbi.nlm.nih.gov/pubmed/31182781The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma. Leukemia. 2020 01; 34(1):167-179.Adamia S, Abiatari I, Amin SB, Fulciniti M, Minvielle S, Li C, Moreau P, Avet-Loiseau H, Munshi NC, Anderson KC. Leukemia2020 0134(1):167-179http://www.ncbi.nlm.nih.gov/pubmed/30422308Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia. Cancer. 2019 02 15; 125(4):541-549.Brunner AM, Neuberg DS, Wander SA, Sadrzadeh H, Ballen KK, Amrein PC, Attar E, Hobbs GS, Chen YB, Perry A, Connolly C, Joseph C, Burke M, Ramos A, Galinsky I, Yen K, Yang H, Straley K, Agresta S, Adamia S, Borger DR, Iafrate A, Graubert TA, Stone RM, Fathi AT. Cancer2019 02 15125(4):541-549http://www.ncbi.nlm.nih.gov/pubmed/28967922Inhibition of USP10 induces degradation of oncogenic FLT3. Nat Chem Biol. 2017 Dec; 13(12):1207-1215.Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ. Nat Chem Biol2017 Dec13(12):1207-1215http://www.ncbi.nlm.nih.gov/pubmed/27081697Characterization of selective and potent PI3Kd inhibitor (PI3KDIN- 015) for B-Cell malignances. Oncotarget. 2016 May 31; 7(22):32641-51.Liu X, Wang A, Liang X, Chen C, Liu J, Zhao Z, Wu H, Deng Y, Wang L, Wang B, Wu J, Liu F, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Brown JR, Griffin JD, Zhang S, Loh T, Zhang X, Wang W, Weisberg EL, Liu J, Liu Q. Oncotarget2016 May 317(22):32641-51http://www.ncbi.nlm.nih.gov/pubmed/26675349Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 03; 127(9):1138-50.Cea M, Cagnetta A, Adamia S, Acharya C, Tai YT, Fulciniti M, Ohguchi H, Munshi A, Acharya P, Bhasin MK, Zhong L, Carrasco R, Monacelli F, Ballestrero A, Richardson P, Gobbi M, Lemoli RM, Munshi N, Hideshima T, Nencioni A, Chauhan D, Anderson KC. Blood2016 Mar 03127(9):1138-50http://www.ncbi.nlm.nih.gov/pubmed/25964294APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clin Cancer Res. 2015 Sep 01; 21(17):3934-45.Cagnetta A, Caffa I, Acharya C, Soncini D, Acharya P, Adamia S, Pierri I, Bergamaschi M, Garuti A, Fraternali G, Mastracci L, Provenzani A, Zucal C, Damonte G, Salis A, Montecucco F, Patrone F, Ballestrero A, Bruzzone S, Gobbi M, Nencioni A, Cea M. Clin Cancer Res2015 Sep 0121(17):3934-45http://www.ncbi.nlm.nih.gov/pubmed/24950197Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer. PLoS One. 2014; 9(6):e100691.Kuppusamy H, Ogmundsdottir HM, Baigorri E, Warkentin A, Steingrimsdottir H, Haraldsdottir V, Mant MJ, Mackey J, Johnston JB, Adamia S, Belch AR, Pilarski LM. PLoS One20149(6):e100691http://www.ncbi.nlm.nih.gov/pubmed/24726781Role of genotype-based approach in the clinical management of adult acute myeloid leukemia with normal cytogenetics. Leuk Res. 2014 Jun; 38(6):649-59.Cagnetta A, Adamia S, Acharya C, Patrone F, Miglino M, Nencioni A, Gobbi M, Cea M. Leuk Res2014 Jun38(6):649-59http://www.ncbi.nlm.nih.gov/pubmed/24574459NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML. Blood. 2014 May 01; 123(18):2816-25.Adamia S, Bar-Natan M, Haibe-Kains B, Pilarski PM, Bach C, Pevzner S, Calimeri T, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Galinsky I, Mathews S, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Tenen DG, Stone RM, Griffin JD. Blood2014 May 01123(18):2816-25http://www.ncbi.nlm.nih.gov/pubmed/25081526Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression. Adv Cancer Res. 2014; 123:67-94.Adamia S, Kriangkum J, Belch AR, Pilarski LM. Adv Cancer Res2014123:67-94http://www.ncbi.nlm.nih.gov/pubmed/24284058A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets. Clin Cancer Res. 2014 Mar 01; 20(5):1135-45.Adamia S, Haibe-Kains B, Pilarski PM, Bar-Natan M, Pevzner S, Avet-Loiseau H, Lode L, Verselis S, Fox EA, Burke J, Galinsky I, Dagogo-Jack I, Wadleigh M, Steensma DP, Motyckova G, Deangelo DJ, Quackenbush J, Stone R, Griffin JD. Clin Cancer Res2014 Mar 0120(5):1135-45http://www.ncbi.nlm.nih.gov/pubmed/23906050Alternative splicing in chronic myeloid leukemia (CML): a novel therapeutic target? Curr Cancer Drug Targets. 2013 Sep; 13(7):735-48.Adamia S, Pilarski PM, Bar-Natan M, Stone RM, Griffin JD. Curr Cancer Drug Targets2013 Sep13(7):735-48http://www.ncbi.nlm.nih.gov/pubmed/23517594Aberrant splicing, hyaluronan synthases and intracellular hyaluronan as drivers of oncogenesis and potential drug targets. Curr Cancer Drug Targets. 2013 May; 13(4):347-61.Adamia S, Pilarski PM, Belch AR, Pilarski LM. Curr Cancer Drug Targets2013 May13(4):347-61http://www.ncbi.nlm.nih.gov/pubmed/21980431Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PLoS One. 2011; 6(9):e25351.Weisberg E, Ray A, Nelson E, Adamia S, Barrett R, Sattler M, Zhang C, Daley JF, Frank D, Fox E, Griffin JD. PLoS One20116(9):e25351http://www.ncbi.nlm.nih.gov/pubmed/21388547The dChip survival analysis module for microarray data. BMC Bioinformatics. 2011 Mar 09; 12:72.Amin SB, Shah PK, Yan A, Adamia S, Minvielle S, Avet-Loiseau H, Munshi NC, Li C. BMC Bioinformatics2011 Mar 0912:72http://www.ncbi.nlm.nih.gov/pubmed/21321360Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications. Blood. 2011 Apr 28; 117(17):4409-19.Jakubikova J, Adamia S, Kost-Alimova M, Klippel S, Cervi D, Daley JF, Cholujova D, Kong SY, Leiba M, Blotta S, Ooi M, Delmore J, Laubach J, Richardson PG, Sedlak J, Anderson KC, Mitsiades CS. Blood2011 Apr 28117(17):4409-19http://www.ncbi.nlm.nih.gov/pubmed/20962322MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma. Blood. 2010 Oct 20.Gatt ME, Zhao JJ, Ebert MS, Zhang Y, Chu Z, Mani M, Gazit R, Carrasco DE, Dutta-Simmons J, Adamia S, Minvielle S, Tai YT, Munshi NC, Avet-Loiseau H, Anderson KC, Carrasco DR. Blood2010 Oct 20http://www.ncbi.nlm.nih.gov/pubmed/20807780Discovery and characterization of novel mutant FLT3 kinase inhibitors. Mol Cancer Ther. 2010 Sep; 9(9):2468-77.Weisberg E, Choi HG, Barrett R, Zhou W, Zhang J, Ray A, Nelson EA, Jiang J, Moreno D, Stone R, Galinsky I, Fox E, Adamia S, Kung AL, Gray NS, Griffin JD. Mol Cancer Ther2010 Sep9(9):2468-77http://www.ncbi.nlm.nih.gov/pubmed/20299508Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 2010 May 27; 115(21):4206-16.Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD. Blood2010 May 27115(21):4206-16http://www.ncbi.nlm.nih.gov/pubmed/19362966Genetic abnormalities in Waldenström's macroglobulinemia. Clin Lymphoma Myeloma. 2009 Mar; 9(1):30-2.Adamia S, Pilarski PM, Belch AR, Pilarski LM. Clin Lymphoma Myeloma2009 Mar9(1):30-2http://www.ncbi.nlm.nih.gov/pubmed/19220283Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom Macroglobulinemia. Br J Haematol. 2009 Apr; 145(1):59-63.Leleu X, Hunter ZR, Xu L, Roccaro AM, Moreau AS, Santos DD, Hatjiharissi E, Bakthavachalam V, Adamia S, Ho AW, Soumerai J, Patterson CJ, Manning RJ, Hamilton S, Verselis S, Fox E, Carrasco R, Ghobrial IM, Treon SP. Br J Haematol2009 Apr145(1):59-63http://www.ncbi.nlm.nih.gov/pubmed/19064987Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs. J Clin Oncol. 2009 Jan 10; 27(2):250-5.Leleu X, Soumerai J, Roccaro A, Hatjiharissi E, Hunter ZR, Manning R, Ciccarelli BT, Sacco A, Ioakimidis L, Adamia S, Moreau AS, Patterson CJ, Ghobrial IM, Treon SP. J Clin Oncol2009 Jan 1027(2):250-5http://www.ncbi.nlm.nih.gov/pubmed/18815290Inherited and acquired variations in the hyaluronan synthase 1 (HAS1) gene may contribute to disease progression in multiple myeloma and Waldenstrom macroglobulinemia. Blood. 2008 Dec 15; 112(13):5111-21.Adamia S, Reichert AA, Kuppusamy H, Kriangkum J, Ghosh A, Hodges JJ, Pilarski PM, Treon SP, Mant MJ, Reiman T, Belch AR, Pilarski LM. Blood2008 Dec 15112(13):5111-21http://www.ncbi.nlm.nih.gov/pubmed/18445657Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells. Mol Cancer Ther. 2008 May; 7(5):1121-9.Weisberg E, Wright RD, McMillin DW, Mitsiades C, Ray A, Barrett R, Adamia S, Stone R, Galinsky I, Kung AL, Griffin JD. Mol Cancer Ther2008 May7(5):1121-9http://www.ncbi.nlm.nih.gov/pubmed/17761288Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice. Exp Hematol. 2007 Sep; 35(9):1366-75.Ditzel Santos D, Ho AW, Tournilhac O, Hatjiharissi E, Leleu X, Xu L, Tassone P, Neri P, Hunter ZR, Chemaly MA, Branagan AR, Manning RJ, Patterson CJ, Moreau AS, Ciccarelli B, Adamia S, Kriangkum J, Kutok JL, Tai YT, Zhang J, Pilarski LM, Anderson KC, Munshi N, Treon SP. Exp Hematol2007 Sep35(9):1366-75http://www.ncbi.nlm.nih.gov/pubmed/17877845Novel agents in the treatment of Waldenström's macroglobulinemia. Clin Lymphoma Myeloma. 2007 Aug; 7 Suppl 5:S199-206.Treon SP, Hatjiharissi E, Leleu X, Moreau AS, Roccaro A, Hunter ZR, Soumerai JD, Ciccarelli B, Xu L, Sacco A, Ngo HT, Jia X, Yang C, Adamia S, Branagan AR, Ho AW, Santos DD, Tournilhac O, Manning RJ, Leduc R, O'Connor K, Nelson M, Patterson CJ, Ghobrial I. Clin Lymphoma Myeloma2007 Aug7 Suppl 5:S199-206http://www.ncbi.nlm.nih.gov/pubmed/17591936Microfluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using reverse transcriptase-polymerase chain reaction analysis of IgH-MMSET hybrid transcripts. J Mol Diagn. 2007 Jul; 9(3):358-67.VanDijken J, Kaigala GV, Lauzon J, Atrazhev A, Adamia S, Taylor BJ, Reiman T, Belch AR, Backhouse CJ, Pilarski LM. J Mol Diagn2007 Jul9(3):358-67http://www.ncbi.nlm.nih.gov/pubmed/16150457An adaptable microvalving system for on-chip polymerase chain reactions. J Immunol Methods. 2005 Oct 20; 305(1):48-58.Pilarski PM, Adamia S, Backhouse CJ. J Immunol Methods2005 Oct 20305(1):48-58http://www.ncbi.nlm.nih.gov/pubmed/16150455Sensitive detection using microfluidics technology of single cell PCR products from high and low abundance IgH VDJ templates in multiple myeloma. J Immunol Methods. 2005 Oct 20; 305(1):94-105.Pilarski LM, Lauzon J, Strachan E, Adamia S, Atrazhev A, Belch AR, Backhouse CJ. J Immunol Methods2005 Oct 20305(1):94-105http://www.ncbi.nlm.nih.gov/pubmed/15794859Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. Clin Lymphoma. 2005 Mar; 5(4):253-6.Adamia S, Treon SP, Reiman T, Tournilhac O, McQuarrie C, Mant MJ, Belch AR, Pilarski LM. Clin Lymphoma2005 Mar5(4):253-6http://www.ncbi.nlm.nih.gov/pubmed/15731173Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. Blood. 2005 Jun 15; 105(12):4836-44.Adamia S, Reiman T, Crainie M, Mant MJ, Belch AR, Pilarski LM. Blood2005 Jun 15105(12):4836-44http://www.ncbi.nlm.nih.gov/pubmed/15720220Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer. Curr Drug Targets Cardiovasc Haematol Disord. 2005 Feb; 5(1):3-14.Adamia S, Maxwell CA, Pilarski LM. Curr Drug Targets Cardiovasc Haematol Disord2005 Feb5(1):3-14http://www.ncbi.nlm.nih.gov/pubmed/15279943A combined dielectrophoresis, traveling wave dielectrophoresis and electrorotation microchip for the manipulation and characterization of human malignant cells. J Microbiol Methods. 2004 Sep; 58(3):387-401.Cen EG, Dalton C, Li Y, Adamia S, Pilarski LM, Kaler KV. J Microbiol Methods2004 Sep58(3):387-401http://www.ncbi.nlm.nih.gov/pubmed/15105292RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma. Blood. 2004 Aug 15; 104(4):1151-8.Maxwell CA, Rasmussen E, Zhan F, Keats JJ, Adamia S, Strachan E, Crainie M, Walker R, Belch AR, Pilarski LM, Barlogie B, Shaughnessy J, Reiman T. Blood2004 Aug 15104(4):1151-8http://www.ncbi.nlm.nih.gov/pubmed/12720129Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia. Semin Oncol. 2003 Apr; 30(2):165-8.Adamia S, Crainie M, Kriangkum J, Mant MJ, Belch AR, Pilarski LM. Semin Oncol2003 Apr30(2):165-8Glucuronosyltransferase92.104936461214723e+0002003-04-01T00:00:002014-06-20T00:00:00Alternative Splicing71.130979616463924e+0002005-02-24T00:00:002023-02-03T00:00:00Multiple Myeloma159.704084033395271e-0012003-04-01T00:00:002023-02-03T00:00:00RNA Precursors29.115129846054657e-0012013-09-01T00:00:002019-06-10T00:00:00RNA Splicing49.027313234179645e-0012008-09-24T00:00:002023-02-03T00:00:00fms-Like Tyrosine Kinase 398.815209491128386e-0012010-08-31T00:00:002020-02-04T00:00:00Waldenstrom Macroglobulinemia97.137629764283868e-0012003-04-01T00:00:002014-06-20T00:00:00Leukemia, Myeloid, Acute126.973158461951298e-0012008-12-08T00:00:002024-05-01T00:00:00Hyaluronan Synthases96.011256957169795e-0012003-04-01T00:00:002014-06-20T00:00:00Hyaluronic Acid24.690277191071969e-0012005-02-01T00:00:002013-05-01T00:00:00Cell Transformation, Neoplastic34.478507133657086e-0012008-12-08T00:00:002014-01-01T00:00:00Transferases24.215462954240787e-0012003-04-01T00:00:002005-02-01T00:00:00Receptor, Notch214.032634431484848e-0012014-02-26T00:00:002014-02-26T00:00:00Hematologic Neoplasms23.961750516478734e-0012019-07-15T00:00:002023-02-03T00:00:00Antineoplastic Agents133.643525923283928e-0012005-02-01T00:00:002024-05-01T00:00:00RNA Processing, Post-Transcriptional13.414160272145004e-0012014-01-01T00:00:002014-01-01T00:00:00Leukemia, Myelogenous, Chronic, BCR-ABL Positive23.333542203713358e-0012008-04-29T00:00:002013-09-01T00:00:00Protein Kinase Inhibitors93.279632744334835e-0012008-04-29T00:00:002022-01-27T00:00:00Syk Kinase33.215088328662179e-0012020-01-14T00:00:002020-02-04T00:00:00Introns22.418397036628693e-0012005-02-24T00:00:002008-09-24T00:00:00Staurosporine42.392166944850346e-0012011-09-28T00:00:002020-01-22T00:00:00Molecular Targeted Therapy32.274778683467200e-0012010-08-31T00:00:002013-11-27T00:00:00Thiophenes22.226334540240793e-0012017-10-02T00:00:002020-11-19T00:00:00Ubiquitin Thiolesterase22.200901101193188e-0012017-10-02T00:00:002020-02-04T00:00:00Gene Expression Regulation, Neoplastic72.171821343775670e-0012004-04-22T00:00:002020-01-22T00:00:00Mutant Proteins22.018497988692210e-0012010-03-18T00:00:002019-07-15T00:00:00Drug Resistance, Multiple11.949558420791516e-0012024-05-01T00:00:002024-05-01T00:00:00MicroRNAs11.935960764415653e-0012019-06-10T00:00:002019-06-10T00:00:00RNA, Messenger41.910034332021585e-0012005-08-22T00:00:002014-01-01T00:00:00Epigenesis, Genetic21.890381330474483e-0012013-09-01T00:00:002014-01-01T00:00:00Proto-Oncogene Proteins c-cbl21.890170757321757e-0012019-07-15T00:00:002020-01-14T00:00:00Glycosyltransferases11.882368331412018e-0012003-04-01T00:00:002003-04-01T00:00:00Drug Resistance, Neoplasm61.804468290893865e-0012010-03-18T00:00:002024-05-01T00:00:00Xenopus Proteins11.612045111613677e-0012003-04-01T00:00:002003-04-01T00:00:00Mitosis41.580179029883204e-0012004-04-22T00:00:002014-01-01T00:00:00STAT Transcription Factors11.578488934904538e-0012020-11-12T00:00:002020-11-12T00:00:00Janus Kinases11.508501480168966e-0012020-11-12T00:00:002020-11-12T00:00:00ADP-ribosyl Cyclase 111.495476997319948e-0012020-11-12T00:00:002020-11-12T00:00:00Cyclin-Dependent Kinase 611.396825621761342e-0012022-01-27T00:00:002022-01-27T00:00:00Hyaluronan Receptors31.366253694876906e-0012003-04-01T00:00:002005-02-01T00:00:00Paraproteinemias21.343702827365970e-0012005-02-24T00:00:002014-06-20T00:00:00Cyclin-Dependent Kinase 411.339803324634469e-0012022-01-27T00:00:002022-01-27T00:00:00Neoplasms31.330146417120149e-0012005-02-01T00:00:002014-01-01T00:00:00Glutarates11.286032263021322e-0012018-11-13T00:00:002018-11-13T00:00:00Fusion Proteins, bcr-abl21.280385196693216e-0012008-04-29T00:00:002010-03-18T00:00:00Leukemia, Myeloid11.276188122066226e-0012020-01-14T00:00:002020-01-14T00:00:00Mutation81.246587982545202e-0012011-09-28T00:00:002020-01-22T00:00:00Apoptosis61.235702405820176e-0012010-08-31T00:00:002024-05-01T00:00:00Leukemia, B-Cell11.200251623449864e-0012016-05-31T00:00:002016-05-31T00:00:00Bridged Bicyclo Compounds, Heterocyclic11.163889051492761e-0012020-11-19T00:00:002020-11-19T00:00:00Cell Line, Tumor131.144673869809169e-0012004-09-01T00:00:002020-01-22T00:00:00Genome-Wide Association Study21.132287347402142e-0012013-11-27T00:00:002014-06-20T00:00:00Mitochondria21.061287886729457e-0012015-05-11T00:00:002020-11-19T00:00:00CD13 Antigens11.054773827445554e-0012013-11-27T00:00:002013-11-27T00:00:00Pyrimidines41.015389582656438e-0012008-04-29T00:00:002020-11-19T00:00:00Piperidines31.010301954472613e-0012015-05-11T00:00:002020-01-22T00:00:00Gene Expression Profiling49.984024712110121e-0022007-07-01T00:00:002014-02-26T00:00:00Acrylamides19.791943340599965e-0022015-05-11T00:00:002015-05-11T00:00:00RNA19.758122021137432e-0022023-02-03T00:00:002023-02-03T00:00:00Humans439.661670891646970e-0022003-04-01T00:00:002024-05-01T00:00:00Sirtuins19.591831703233437e-0022015-12-16T00:00:002015-12-16T00:00:00Cyclosporine19.487467330969265e-0022015-05-11T00:00:002015-05-11T00:00:00Membrane Proteins29.158098652806981e-0022003-04-01T00:00:002014-02-26T00:00:00Isocitrate Dehydrogenase19.032312695011878e-0022018-11-13T00:00:002018-11-13T00:00:00Small Molecule Libraries18.961549397811895e-0022017-10-02T00:00:002017-10-02T00:00:00Phosphoinositide-3 Kinase Inhibitors18.950689539409748e-0022016-05-31T00:00:002016-05-31T00:00:00Proto-Oncogene Proteins c-kit28.877645778889658e-0022010-03-18T00:00:002019-07-15T00:00:00Endoplasmic Reticulum Stress18.819838147677031e-0022015-05-11T00:00:002015-05-11T00:00:00Spindle Apparatus18.628315963085810e-0022014-01-01T00:00:002014-01-01T00:00:00Reverse Transcriptase Polymerase Chain Reaction38.622598329369055e-0022005-02-24T00:00:002009-02-06T00:00:00Genetic Variation38.536513144844282e-0022008-09-24T00:00:002014-01-01T00:00:00Molecular Sequence Annotation18.522732402144632e-0022013-11-27T00:00:002013-11-27T00:00:00Sulfonamides18.284554540950398e-0022020-11-19T00:00:002020-11-19T00:00:00Gene Expression Regulation, Leukemic18.258678039248905e-0022014-02-26T00:00:002014-02-26T00:00:00Microfluidic Analytical Techniques28.013019530800443e-0022005-08-22T00:00:002007-07-01T00:00:00Disease Progression47.940087139406697e-0022007-07-01T00:00:002014-01-01T00:00:00Membrane Glycoproteins17.723580854525552e-0022020-11-12T00:00:002020-11-12T00:00:00Cluster Analysis27.697095134393746e-0022011-03-09T00:00:002014-02-26T00:00:00Electrophoresis, Capillary27.452943204452150e-0022005-02-24T00:00:002009-02-06T00:00:00Extracellular Matrix Proteins27.420506450582415e-0022003-04-01T00:00:002004-04-22T00:00:00Signal Transduction77.312644642296577e-0022011-02-14T00:00:002020-11-19T00:00:00Benzothiazoles27.157469543574933e-0022019-07-15T00:00:002020-01-22T00:00:00Green Fluorescent Proteins17.133170269695283e-0022014-01-01T00:00:002014-01-01T00:00:00Immunoglobulin Heavy Chains27.114986584305287e-0022005-08-19T00:00:002015-05-11T00:00:00Sorafenib27.090211643835284e-0022019-07-15T00:00:002020-01-22T00:00:00Polymorphism, Single Nucleotide37.082939753366316e-0022005-03-01T00:00:002014-06-20T00:00:00Hematopoietic System17.055183108660570e-0022008-09-24T00:00:002008-09-24T00:00:00Animals146.967178882654734e-0022005-02-01T00:00:002024-05-01T00:00:00Nucleosides16.961683483083893e-0022008-12-08T00:00:002008-12-08T00:00:00Drug Design16.957005727567614e-0022013-09-01T00:00:002013-09-01T00:00:00Transcriptional Activation16.923459258860987e-0022014-02-26T00:00:002014-02-26T00:00:00Genes, Regulator16.879774712205707e-0022009-02-06T00:00:002009-02-06T00:00:00Receptor, Platelet-Derived Growth Factor alpha16.858089828705517e-0022010-03-18T00:00:002010-03-18T00:00:00Prognosis76.845288250085171e-0022004-04-22T00:00:002018-11-13T00:00:00src-Family Kinases16.582550997491685e-0022010-03-18T00:00:002010-03-18T00:00:00Cell Line26.548367379284420e-0022007-09-01T00:00:002014-02-26T00:00:00Leukocytes, Mononuclear26.475064939770223e-0022003-04-01T00:00:002005-02-24T00:00:00Leukemia16.415365138275894e-0022015-05-11T00:00:002015-05-11T00:00:00Gene Frequency16.312138087659487e-0022013-11-27T00:00:002013-11-27T00:00:00Chromosomes, Human, Pair 1416.264354864578423e-0022007-07-01T00:00:002007-07-01T00:00:00Polymerase Chain Reaction26.103614279931759e-0022005-08-19T00:00:002005-08-22T00:00:00Chromosomes, Human, Pair 416.094407348027518e-0022007-07-01T00:00:002007-07-01T00:00:00Amino Acid Sequence26.080528202287629e-0022014-01-01T00:00:002016-05-31T00:00:00Phenylurea Compounds26.024301870441061e-0022019-07-15T00:00:002020-01-22T00:00:00Thiazoles26.007111444992614e-0022010-03-18T00:00:002011-09-28T00:00:00Drug Screening Assays, Antitumor25.922802107535988e-0022017-10-02T00:00:002019-07-15T00:00:00DNA Damage15.901303669023942e-0022015-12-16T00:00:002015-12-16T00:00:00Electrophoresis, Microchip15.896448655686491e-0022005-08-19T00:00:002005-08-19T00:00:00Enzyme Inhibitors15.873282824718978e-0022016-05-31T00:00:002016-05-31T00:00:00Biomarkers, Tumor25.771136742276239e-0022013-11-27T00:00:002018-11-13T00:00:00Thalidomide15.760561888201276e-0022011-02-14T00:00:002011-02-14T00:00:00Point Mutation15.747619747897873e-0022010-08-31T00:00:002010-08-31T00:00:00Plasma Cells15.692818700920335e-0022009-02-06T00:00:002009-02-06T00:00:00Bone Marrow35.664397733286589e-0022005-02-24T00:00:002020-11-12T00:00:00Codon, Terminator15.445706730361950e-0022005-02-24T00:00:002005-02-24T00:00:00Mice95.428331311099881e-0022007-09-01T00:00:002024-05-01T00:00:00Neoplasm Recurrence, Local25.421460446941977e-0022011-02-14T00:00:002022-01-27T00:00:00Electrophoresis15.395808110101773e-0022004-09-01T00:00:002004-09-01T00:00:00Granulocyte Precursor Cells15.349268154771095e-0022024-05-01T00:00:002024-05-01T00:00:00Bone Marrow Cells35.247354834421496e-0022003-04-01T00:00:002011-02-14T00:00:00Aniline Compounds25.186410323613368e-0022019-07-15T00:00:002020-01-22T00:00:00Protease Inhibitors15.182135938093356e-0022007-08-01T00:00:002007-08-01T00:00:00Pyrazines25.108715231363810e-0022019-07-15T00:00:002020-01-22T00:00:00Drug Synergism25.075591120530772e-0022015-05-11T00:00:002020-01-22T00:00:00Benzimidazoles25.035005987445426e-0022019-07-15T00:00:002020-01-22T00:00:00Codon14.939922018170092e-0022005-02-24T00:00:002005-02-24T00:00:00Genetic Predisposition to Disease14.869646869602964e-0022005-03-01T00:00:002005-03-01T00:00:00Neoplastic Stem Cells14.854699969657981e-0022011-02-14T00:00:002011-02-14T00:00:00Oligonucleotide Array Sequence Analysis14.805609939716853e-0022011-03-09T00:00:002011-03-09T00:00:00Piperazines24.775015310359194e-0022010-03-18T00:00:002011-09-28T00:00:00Exons14.728501799561925e-0022008-09-24T00:00:002008-09-24T00:00:00Leukemia, Lymphocytic, Chronic, B-Cell14.714069443247134e-0022014-06-20T00:00:002014-06-20T00:00:00Cell Proliferation54.710871596300253e-0022008-04-29T00:00:002020-01-22T00:00:00Sequence Analysis, DNA34.642750990750703e-0022005-02-24T00:00:002014-06-20T00:00:00Antigens, CD2014.584370955348759e-0022003-04-01T00:00:002003-04-01T00:00:00Burkitt Lymphoma14.501218045339075e-0022004-09-01T00:00:002004-09-01T00:00:00Translocation, Genetic14.444252112471994e-0022007-07-01T00:00:002007-07-01T00:00:00Molecular Sequence Data14.400665787563067e-0022014-01-01T00:00:002014-01-01T00:00:00Up-Regulation24.206344641051391e-0022005-03-01T00:00:002011-09-28T00:00:00Cell Survival34.195336553314279e-0022011-02-14T00:00:002017-10-02T00:00:00DNA Primers14.128764379290661e-0022005-02-24T00:00:002005-02-24T00:00:00Transplantation, Heterologous14.106831713485509e-0022007-09-01T00:00:002007-09-01T00:00:00Gene Expression34.070037686486180e-0022003-04-01T00:00:002015-05-11T00:00:00DNA, Neoplasm14.028056440342098e-0022005-08-19T00:00:002005-08-19T00:00:00Treatment Outcome34.006797345415968e-0022005-02-24T00:00:002014-02-26T00:00:00Genotype34.006499128285893e-0022005-03-01T00:00:002014-06-20T00:00:00Cloning, Molecular13.868448889380439e-0022005-02-24T00:00:002005-02-24T00:00:00Avapritinib13.849663411972920e-0022019-07-15T00:00:002019-07-15T00:00:00Molecular Structure23.846148752154478e-0022010-03-18T00:00:002017-10-02T00:00:00B-Lymphocytes23.818142971490676e-0022009-02-06T00:00:002014-06-20T00:00:00Tumor Cells, Cultured23.691368017961365e-0022015-05-11T00:00:002017-10-02T00:00:00Myelodysplastic Syndromes13.658229537333976e-0022008-12-08T00:00:002008-12-08T00:00:00Pyrazoles23.599415686323645e-0022019-07-15T00:00:002020-11-12T00:00:00Oncogene Proteins, Fusion13.598524279416626e-0022007-07-01T00:00:002007-07-01T00:00:00Isoenzymes13.563703754903981e-0022003-04-01T00:00:002003-04-01T00:00:00Immunologic Factors13.483862917129361e-0022007-08-01T00:00:002007-08-01T00:00:00Base Sequence13.428313593060167e-0022008-09-24T00:00:002008-09-24T00:00:00Blotting, Western13.374644680448495e-0022005-02-24T00:00:002005-02-24T00:00:00Triazines13.254087084129323e-0022019-07-15T00:00:002019-07-15T00:00:00Antineoplastic Combined Chemotherapy Protocols13.228433530636304e-0022018-11-13T00:00:002018-11-13T00:00:00Software13.144504933788365e-0022011-03-09T00:00:002011-03-09T00:00:00ets-Domain Protein Elk-113.022961937014242e-0022015-12-16T00:00:002015-12-16T00:00:00Ligands12.968133338568347e-0022003-04-01T00:00:002003-04-01T00:00:00Proto-Oncogene Proteins22.901380520302110e-0022014-03-18T00:00:002020-11-19T00:00:00Xenograft Model Antitumor Assays12.876698374868790e-0022024-05-01T00:00:002024-05-01T00:00:00Reproducibility of Results12.871026967587835e-0022013-11-27T00:00:002013-11-27T00:00:00Nitriles12.857925308748793e-0022020-11-12T00:00:002020-11-12T00:00:00Mutagens12.819439140402813e-0022015-12-16T00:00:002015-12-16T00:00:00Nicotinamide Phosphoribosyltransferase12.778245396050338e-0022015-05-11T00:00:002015-05-11T00:00:00Ubiquitination12.732647047617643e-0022020-02-04T00:00:002020-02-04T00:00:00Niacin12.691318815378528e-0022015-05-11T00:00:002015-05-11T00:00:00Stromal Cells22.635824789781733e-0022008-04-29T00:00:002011-02-14T00:00:00ATP Binding Cassette Transporter, Subfamily B12.623791032158204e-0022015-05-11T00:00:002015-05-11T00:00:00Membrane Potential, Mitochondrial12.622370711838302e-0022015-05-11T00:00:002015-05-11T00:00:00WT1 Proteins12.486981362119682e-0022014-03-18T00:00:002014-03-18T00:00:00Mice, Inbred NOD12.465543018154935e-0022017-10-02T00:00:002017-10-02T00:00:00Nucleophosmin12.455445575437574e-0022014-03-18T00:00:002014-03-18T00:00:00Primary Cell Culture12.443596033284641e-0022015-05-11T00:00:002015-05-11T00:00:00Mice, Nude22.440040591552826e-0022008-04-29T00:00:002010-08-31T00:00:00Acetylation12.426392967155992e-0022015-12-16T00:00:002015-12-16T00:00:00Niacinamide12.419251768625970e-0022015-05-11T00:00:002015-05-11T00:00:00Unfolded Protein Response12.415782096588287e-0022015-05-11T00:00:002015-05-11T00:00:00Pyrroles12.412190590078862e-0022019-07-15T00:00:002019-07-15T00:00:00CCAAT-Enhancer-Binding Proteins12.408825955264477e-0022014-03-18T00:00:002014-03-18T00:00:00DNA Methyltransferase 3A12.396483217576608e-0022014-03-18T00:00:002014-03-18T00:00:00Neoplasms, Experimental12.370076228241629e-0022017-10-02T00:00:002017-10-02T00:00:00Ubiquitin12.323889742349395e-0022017-10-02T00:00:002017-10-02T00:00:00Female82.280017478761636e-0022004-04-22T00:00:002022-01-27T00:00:00Structure-Activity Relationship12.271305051589477e-0022017-10-02T00:00:002017-10-02T00:00:00DNA (Cytosine-5-)-Methyltransferases12.247651230514489e-0022014-03-18T00:00:002014-03-18T00:00:00Enzyme Stability12.165306136437121e-0022011-09-28T00:00:002011-09-28T00:00:00DNA12.160229410030008e-0022005-02-24T00:00:002005-02-24T00:00:00Case-Control Studies22.153360580432476e-0022005-03-01T00:00:002009-02-06T00:00:00Dioxygenases12.139679874892856e-0022014-03-18T00:00:002014-03-18T00:00:00Lysine12.109028567954490e-0022015-12-16T00:00:002015-12-16T00:00:00NAD12.094427237317112e-0022015-05-11T00:00:002015-05-11T00:00:00Colony-Forming Units Assay12.068823459949706e-0022011-02-14T00:00:002011-02-14T00:00:00Cell Fractionation12.061684441715909e-0022011-02-14T00:00:002011-02-14T00:00:00Half-Life12.039548309304457e-0022011-09-28T00:00:002011-09-28T00:00:00Syndecan-112.013523064359917e-0022011-02-14T00:00:002011-02-14T00:00:00Cell Growth Processes11.943392511079220e-0022010-08-31T00:00:002010-08-31T00:00:00Cells, Cultured21.897539586763304e-0022007-09-01T00:00:002020-02-04T00:00:00Threonine11.882158232329710e-0022010-03-18T00:00:002010-03-18T00:00:00Chlorambucil11.856781926189401e-0022008-12-08T00:00:002008-12-08T00:00:00Doxorubicin11.838512967656762e-0022015-12-16T00:00:002015-12-16T00:00:00Survival Rate21.831986847805093e-0022004-04-22T00:00:002018-11-13T00:00:00Chromosome Aberrations11.818457640612586e-0022015-05-11T00:00:002015-05-11T00:00:00Adenosine Triphosphate11.814954028062932e-0022015-05-11T00:00:002015-05-11T00:00:00MAP Kinase Signaling System11.806883704821057e-0022015-12-16T00:00:002015-12-16T00:00:00Cladribine11.803278522740149e-0022008-12-08T00:00:002008-12-08T00:00:00Peptide Fragments11.729759064612368e-0022020-11-19T00:00:002020-11-19T00:00:00Disease Models, Animal11.692744169807656e-0022007-09-01T00:00:002007-09-01T00:00:00Autophagy11.683415735561863e-0022016-05-31T00:00:002016-05-31T00:00:00ATP-Binding Cassette Transporters11.663292506821954e-0022011-02-14T00:00:002011-02-14T00:00:00Aged, 80 and over41.650837230915979e-0022008-12-08T00:00:002018-11-13T00:00:00Genes, Immunoglobulin Heavy Chain11.646578845540155e-0022007-07-01T00:00:002007-07-01T00:00:00Vidarabine11.644458736443278e-0022008-12-08T00:00:002008-12-08T00:00:00Immunoblotting11.643620584656242e-0022010-08-31T00:00:002010-08-31T00:00:00Imatinib Mesylate11.639127536495415e-0022010-03-18T00:00:002010-03-18T00:00:00Tyrosine11.636272675177451e-0022011-09-28T00:00:002011-09-28T00:00:00Lenalidomide11.635487786862030e-0022011-02-14T00:00:002011-02-14T00:00:00Phosphatidylinositol 3-Kinases11.596045150699651e-0022016-05-31T00:00:002016-05-31T00:00:00Tumor Microenvironment11.574334389940934e-0022020-11-12T00:00:002020-11-12T00:00:00DNA Repair11.528904459474702e-0022015-12-16T00:00:002015-12-16T00:00:00Models, Molecular11.511540340097873e-0022016-05-31T00:00:002016-05-31T00:00:00Amino Acid Substitution11.468455652318096e-0022010-03-18T00:00:002010-03-18T00:00:00Dose-Response Relationship, Drug11.464152735645536e-0022017-10-02T00:00:002017-10-02T00:00:00Genes, Neoplasm11.444794121746651e-0022007-07-01T00:00:002007-07-01T00:00:00Immunoglobulin Fragments11.438472500313881e-0022005-08-19T00:00:002005-08-19T00:00:00Templates, Genetic11.436973540346515e-0022005-08-19T00:00:002005-08-19T00:00:00Gene Expression Regulation11.426961079447139e-0022003-04-01T00:00:002003-04-01T00:00:00Histones11.410392659357664e-0022015-12-16T00:00:002015-12-16T00:00:00Aged61.373031078831693e-0022004-04-22T00:00:002018-11-13T00:00:00beta 2-Microglobulin11.331324494038376e-0022005-08-22T00:00:002005-08-22T00:00:00Benzamides11.294814900126356e-0022010-03-18T00:00:002010-03-18T00:00:00Semiconductors11.276877124843581e-0022004-09-01T00:00:002004-09-01T00:00:00In Vitro Techniques11.276002428752924e-0022010-03-18T00:00:002010-03-18T00:00:00Cell Division11.267039024570653e-0022011-02-14T00:00:002011-02-14T00:00:00Antibodies, Monoclonal11.265109093637685e-0022020-11-12T00:00:002020-11-12T00:00:00Statistics, Nonparametric11.253116427717480e-0022009-02-06T00:00:002009-02-06T00:00:00Microelectrodes11.239874431289304e-0022004-09-01T00:00:002004-09-01T00:00:00Risk Factors21.229822335949059e-0022005-03-01T00:00:002014-06-20T00:00:00Middle Aged61.228952624575633e-0022004-04-22T00:00:002018-11-13T00:00:00Time Factors11.227411537472004e-0022005-02-24T00:00:002005-02-24T00:00:00Follow-Up Studies21.203703645478726e-0022008-12-08T00:00:002018-11-13T00:00:00Cell Size11.172328993752331e-0022004-09-01T00:00:002004-09-01T00:00:00Mice, SCID11.168539729364873e-0022007-09-01T00:00:002007-09-01T00:00:00Cell Cycle11.167266257102940e-0022010-08-31T00:00:002010-08-31T00:00:00Drug Discovery11.110565389887630e-0022010-03-18T00:00:002010-03-18T00:00:00Transcription, Genetic21.108997227406982e-0022005-08-19T00:00:002005-08-22T00:00:00RNA, Neoplasm11.097064985784841e-0022004-04-22T00:00:002004-04-22T00:00:00Lymphoma, Non-Hodgkin11.077750144480493e-0022008-12-08T00:00:002008-12-08T00:00:00Sensitivity and Specificity21.068651771440957e-0022005-08-19T00:00:002007-07-01T00:00:00Angiogenesis Inhibitors11.032199999527648e-0022011-02-14T00:00:002011-02-14T00:00:00Mutation, Missense11.030791594608281e-0022010-03-18T00:00:002010-03-18T00:00:00Phosphorylation11.025038991879542e-0022011-09-28T00:00:002011-09-28T00:00:00Kaplan-Meier Estimate11.022596546893602e-0022011-03-09T00:00:002011-03-09T00:00:00Neoplasm Staging11.003814677657757e-0022015-05-11T00:00:002015-05-11T00:00:00Monitoring, Physiologic19.710554786845725e-0032007-07-01T00:00:002007-07-01T00:00:00Models, Biological19.700405035197736e-0032015-12-16T00:00:002015-12-16T00:00:00Nuclear Proteins19.351756754279305e-0032014-03-18T00:00:002014-03-18T00:00:00Protein Isoforms19.341735655662225e-0032004-04-22T00:00:002004-04-22T00:00:00Adult48.667404407613143e-0032008-12-08T00:00:002018-11-13T00:00:00Male58.247076764999245e-0032008-12-08T00:00:002018-11-13T00:00:00DNA-Binding Proteins17.994064109719968e-0032014-03-18T00:00:002014-03-18T00:00:00Graft Survival17.778146236521568e-0032007-09-01T00:00:002007-09-01T00:00:00Proportional Hazards Models17.674912662405805e-0032011-03-09T00:00:002011-03-09T00:00:00Breast Neoplasms27.122232606195485e-0032011-03-09T00:00:002014-06-20T00:00:00Mice, Transgenic16.939094115911850e-0032007-09-01T00:00:002007-09-01T00:00:00Prospective Studies16.445534683554464e-0032018-11-13T00:00:002018-11-13T00:00:00Genome, Human15.829847668338376e-0032005-08-19T00:00:002005-08-19T00:00:00Survival Analysis15.581409850543091e-0032004-04-22T00:00:002004-04-22T00:00:00Young Adult15.440588026665740e-0032018-11-13T00:00:002018-11-13T00:00:00Cell Differentiation15.325215433719645e-0032009-02-06T00:00:002009-02-06T00:00:00Incidence14.936754171098140e-0032008-12-08T00:00:002008-12-08T00:00:00Algorithms13.886829490277946e-0032007-07-01T00:00:002007-07-01T00:00:00Retrospective Studies12.344850401823884e-0032008-12-08T00:00:002008-12-08T00:00:00Iannis Adamopoulos, D.Phil.IannisAdamopoulos

Beth Israel Deaconess Medical CenterDept of Medicine, Division of Rheumatology330 Brookline AveBoston, MA 02215617 735 4162

1BIDMCBeth Israel Deaconess Medical CenterMedicineRheumatologyAssociate Professor of MedicineAssociate Professorhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=177693711University Of OxfordOxford, UKD.Phil09/2006ImmunologyWashington University of St LouisPost-doc09/2007ImmunologyDNAX Research InstitutePalo Alto, CAPost-doc12/2010ImmunologyPrincipal InvestigatorThe IL-23/IL-17 Axis in Inflammatory ArthritisNIH2012-04-012025-11-30ADAMOPOULOS, IANNIS ELIASPrincipal investigatorRole of splicing factor SRSF1 in T cell function and autoimmunityNIH2016-07-222022-08-31ADAMOPOULOS, IANNIS ELIASPrincipal InvestigatorCellular and Molecular Mechanisms of IL-17A in the Pathogenesis of Psoriatic ArthritisNIH2025-05-152030-03-31ADAMOPOULOS, IANNIS ELIASCo-Principal InvestigatorThe Impact of the Bone Marrow Niche's Immune Privilege on Psoriatic ArthritisNIH2025-08-082029-07-31FUJISAKI, JOJIhttp://www.ncbi.nlm.nih.gov/pubmed/40628221Trained immunity of osteoclasts controls inflammatory arthritis. Dev Cell. 2025 Jul 07; 60(13):1813-1815.Adamopoulos IE. Dev Cell2025 Jul 0760(13):1813-1815http://www.ncbi.nlm.nih.gov/pubmed/40500630Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies. Trends Mol Med. 2025 Jul; 31(7):682-683.Adamopoulos IE, Baraliakos X, Ritchlin C. Trends Mol Med2025 Jul31(7):682-683http://www.ncbi.nlm.nih.gov/pubmed/40011156Novel insights and recent progress in osteoimmunology. Trends Immunol. 2025 Mar; 46(3):192-194.Adamopoulos IE, Choi Y, Takayanagi H. Trends Immunol2025 Mar46(3):192-194http://www.ncbi.nlm.nih.gov/pubmed/38301504IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis. J Autoimmun. 2024 02; 143:103167.Furuya H, Nguyen CT, Chan T, Marusina AI, Merleev AA, Garcia-Hernandez ML, Hsieh SL, Tsokos GC, Ritchlin CT, Tagkopoulos I, Maverakis E, Adamopoulos IE. J Autoimmun2024 02143:103167http://www.ncbi.nlm.nih.gov/pubmed/37674048Innate immune memory in inflammatory arthritis. Nat Rev Rheumatol. 2023 10; 19(10):627-639.Jeljeli MM, Adamopoulos IE. Nat Rev Rheumatol2023 1019(10):627-639http://www.ncbi.nlm.nih.gov/pubmed/37488297IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration. Nat Rev Rheumatol. 2023 09; 19(9):535-536.Adamopoulos IE, Kuchroo V. Nat Rev Rheumatol2023 0919(9):535-536http://www.ncbi.nlm.nih.gov/pubmed/36787107Interleukin-23 Regulates Inflammatory Osteoclastogenesis via Activation of CLEC5A(+) Osteoclast Precursors. Arthritis Rheumatol. 2023 08; 75(8):1477-1489.Furuya H, Nguyen CT, Gu R, Hsieh SL, Maverakis E, Adamopoulos IE. Arthritis Rheumatol2023 0875(8):1477-1489http://www.ncbi.nlm.nih.gov/pubmed/37037268IL-27 attenuates IL-23 mediated inflammatory arthritis. Clin Immunol. 2023 06; 251:109327.Sarin R, Gu R, Jalali Z, Maverakis E, Tsokos MG, Adamopoulos IE. Clin Immunol2023 06251:109327http://www.ncbi.nlm.nih.gov/pubmed/35862195Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI Insight. 2022 08 22; 7(16).Merleev A, Ji-Xu A, Toussi A, Tsoi LC, Le ST, Luxardi G, Xing X, Wasikowski R, Liakos W, Brüggen MC, Elder JT, Adamopoulos IE, Izumiya Y, Leal AR, Li Q, Kuzminykh NY, Kirane A, Marusina AI, Gudjonsson JE, Maverakis E. JCI Insight2022 08 227(16)http://www.ncbi.nlm.nih.gov/pubmed/35320625Peripheral ?d T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic Arthritis. Arthritis Rheumatol. 2022 09; 74(9):1524-1534.Nguyen CT, Furuya H, Das D, Marusina AI, Merleev AA, Ravindran R, Jalali Z, Khan IH, Maverakis E, Adamopoulos IE. Arthritis Rheumatol2022 0974(9):1524-1534http://www.ncbi.nlm.nih.gov/pubmed/35613697Serine and arginine rich splicing factor 1 deficiency alters pathways involved in IL-17A expression and is implicated in human psoriasis. Clin Immunol. 2022 07; 240:109041.Su S, Katopodi XL, Pita-Juarez YH, Maverakis E, Vlachos IS, Adamopoulos IE. Clin Immunol2022 07240:109041http://www.ncbi.nlm.nih.gov/pubmed/33956666IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation. J Clin Invest. 2021 06 15; 131(12).Li H, Tsokos MG, Bhargava R, Adamopoulos IE, Menn-Josephy H, Stillman IE, Rosenstiel P, Jordan J, Tsokos GC. J Clin Invest2021 06 15131(12)http://www.ncbi.nlm.nih.gov/pubmed/33679714IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong? Front Immunol. 2020; 11:623874.Baeten D, Adamopoulos IE. Front Immunol202011:623874http://www.ncbi.nlm.nih.gov/pubmed/33397652Axial spondyloarthritis: new advances in diagnosis and management. BMJ. 2021 01 04; 372:m4447.Ritchlin C, Adamopoulos IE. BMJ2021 01 04372:m4447http://www.ncbi.nlm.nih.gov/pubmed/32503973Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells. Nat Commun. 2020 06 05; 11(1):2859.Li H, Adamopoulos IE, Moulton VR, Stillman IE, Herbert Z, Moon JJ, Sharabi A, Krishfield S, Tsokos MG, Tsokos GC. Nat Commun2020 06 0511(1):2859http://www.ncbi.nlm.nih.gov/pubmed/30663867Interleukin-17A and Pathologic New Bone Formation: The Myth of Prometheus Revisited. Arthritis Rheumatol. 2019 04; 71(4):483-485.Adamopoulos IE. Arthritis Rheumatol2019 0471(4):483-485http://www.ncbi.nlm.nih.gov/pubmed/31693001Go with the flow-hidden vascular passages in bone. Nat Metab. 2019 Feb; 1(2):173-174.Ritchlin C, Adamopoulos IE. Nat Metab2019 Feb1(2):173-174http://www.ncbi.nlm.nih.gov/pubmed/29765156?dTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. Sci Rep. 2018 05 15; 8(1):7590.Bouchareychas L, Grössinger EM, Kang M, Adamopoulos IE. Sci Rep2018 05 158(1):7590http://www.ncbi.nlm.nih.gov/pubmed/29287995Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rß1. Immunity. 2018 01 16; 48(1):45-58.e6.Bloch Y, Bouchareychas L, Merceron R, Skladanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Immunity2018 01 1648(1):45-58.e6http://www.ncbi.nlm.nih.gov/pubmed/29246953Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis. J Immunol. 2018 01 15; 200(2):749-757.Grössinger EM, Kang M, Bouchareychas L, Sarin R, Haudenschild DR, Borodinsky LN, Adamopoulos IE. J Immunol2018 01 15200(2):749-757http://www.ncbi.nlm.nih.gov/pubmed/27895169Critical Role of LTB4/BLT1 in IL-23-Induced Synovial Inflammation and Osteoclastogenesis via NF-?B. J Immunol. 2017 01 01; 198(1):452-460.Bouchareychas L, Grössinger EM, Kang M, Qiu H, Adamopoulos IE. J Immunol2017 01 01198(1):452-460http://www.ncbi.nlm.nih.gov/pubmed/27798153T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia. J Immunol. 2016 12 01; 197(11):4403-4412.Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE. J Immunol2016 12 01197(11):4403-4412http://www.ncbi.nlm.nih.gov/pubmed/27330028Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun. 2016 09; 73:73-84.Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Adamopoulos IE. J Autoimmun2016 0973:73-84http://www.ncbi.nlm.nih.gov/pubmed/25443625Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis. Arthritis Res Ther. 2014 Dec 02; 16(6):496.Dixit N, Wu DJ, Belgacem YH, Borodinsky LN, Gershwin ME, Adamopoulos IE. Arthritis Res Ther2014 Dec 0216(6):496http://www.ncbi.nlm.nih.gov/pubmed/25452564Crosstalk among IL-23 and DNAX activating protein of 12 kDa-dependent pathways promotes osteoclastogenesis. J Immunol. 2015 Jan 01; 194(1):316-24.Shin HS, Sarin R, Dixit N, Wu J, Gershwin E, Bowman EP, Adamopoulos IE. J Immunol2015 Jan 01194(1):316-24http://www.ncbi.nlm.nih.gov/pubmed/25422000Alternative pathways of osteoclastogenesis in inflammatory arthritis. Nat Rev Rheumatol. 2015 Mar; 11(3):189-94.Adamopoulos IE, Mellins ED. Nat Rev Rheumatol2015 Mar11(3):189-94http://www.ncbi.nlm.nih.gov/pubmed/25198012Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014 Sep 08; 5:4692.Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS. Nat Commun2014 Sep 085:4692http://www.ncbi.nlm.nih.gov/pubmed/24567524IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Ann Rheum Dis. 2015 Jun; 74(6):1284-92.Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, Mcclanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP. Ann Rheum Dis2015 Jun74(6):1284-92http://www.ncbi.nlm.nih.gov/pubmed/24424175The IL-23/IL-17 axis in psoriatic arthritis. Autoimmun Rev. 2014 Apr-May; 13(4-5):496-502.Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE. Autoimmun Rev2014 Apr-May13(4-5):496-502http://www.ncbi.nlm.nih.gov/pubmed/23359064The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol. 2013 Oct; 45(2):217-26.Yang CY, Leung PS, Adamopoulos IE, Gershwin ME. Clin Rev Allergy Immunol2013 Oct45(2):217-26http://www.ncbi.nlm.nih.gov/pubmed/23935987A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS One. 2013; 8(7):e69333.Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, Wójcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS. PLoS One20138(7):e69333http://www.ncbi.nlm.nih.gov/pubmed/23165310The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction. Cytokine Growth Factor Rev. 2013 Apr; 24(2):115-21.Adamopoulos IE, Pflanz S. Cytokine Growth Factor Rev2013 Apr24(2):115-21http://www.ncbi.nlm.nih.gov/pubmed/22867712Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6. J Autoimmun. 2012 Dec; 39(4):369-76.Dickerson TJ, Suzuki E, Stanecki C, Shin HS, Qui H, Adamopoulos IE. J Autoimmun2012 Dec39(4):369-76http://www.ncbi.nlm.nih.gov/pubmed/21670317IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011 Jul 15; 187(2):951-9.Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, Chou CC, Pierce RH, Yao W, Lane NE, Laface D, Bowman EP. J Immunol2011 Jul 15187(2):951-9http://www.ncbi.nlm.nih.gov/pubmed/20925596Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. Autoimmunity. 2011 May; 44(3):243-52.Chao CC, Chen SJ, Adamopoulos IE, Davis N, Hong K, Vu A, Kwan S, Fayadat-Dilman L, Asio A, Bowman EP. Autoimmunity2011 May44(3):243-52http://www.ncbi.nlm.nih.gov/pubmed/20380588Structural, cellular, and molecular evaluation of bone erosion in experimental models of rheumatoid arthritis: assessment by µCT, histology, and serum biomarkers. Autoimmunity. 2010 Dec; 43(8):642-53.Chao CC, Chen SJ, Adamopoulos IE, Judo M, Asio A, Ayanoglu G, Bowman EP. Autoimmunity2010 Dec43(8):642-53http://www.ncbi.nlm.nih.gov/pubmed/20212065Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. J Exp Med. 2010 Mar 15; 207(3):579-89.Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, Phillips JH, Cua DJ. J Exp Med2010 Mar 15207(3):579-89http://www.ncbi.nlm.nih.gov/pubmed/20167120Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. Arthritis Res Ther. 2010; 12(1):R29.Adamopoulos IE, Chao CC, Geissler R, Laface D, Blumenschein W, Iwakura Y, McClanahan T, Bowman EP. Arthritis Res Ther201012(1):R29http://www.ncbi.nlm.nih.gov/pubmed/18983698Immune regulation of bone loss by Th17 cells. Arthritis Res Ther. 2008; 10(5):225.Adamopoulos IE, Bowman EP. Arthritis Res Ther200810(5):225http://www.ncbi.nlm.nih.gov/pubmed/18835879Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. Rheumatology (Oxford). 2008 Dec; 47(12):1761-7.Harney SM, Vilariño-Güell C, Adamopoulos IE, Sims AM, Lawrence RW, Cardon LR, Newton JL, Meisel C, Pointon JJ, Darke C, Athanasou N, Wordsworth BP, Brown MA. Rheumatology (Oxford)2008 Dec47(12):1761-7http://www.ncbi.nlm.nih.gov/pubmed/17533390Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma. Br J Cancer. 2007 Jun 04; 96(11):1716-22.Lau YS, Adamopoulos IE, Sabokbar A, Giele H, Gibbons CL, Athanasou NA. Br J Cancer2007 Jun 0496(11):1716-22http://www.ncbi.nlm.nih.gov/pubmed/16817218Macrophage-mediated biodegradation of poly(DL-lactide-co-glycolide) in vitro. J Biomed Mater Res A. 2006 Dec 01; 79(3):582-90.Xia Z, Huang Y, Adamopoulos IE, Walpole A, Triffitt JT, Cui Z. J Biomed Mater Res A2006 Dec 0179(3):582-90http://www.ncbi.nlm.nih.gov/pubmed/17022947Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis. Biochem Biophys Res Commun. 2006 Nov 17; 350(2):478-83.Adamopoulos IE, Xia Z, Lau YS, Athanasou NA. Biochem Biophys Res Commun2006 Nov 17350(2):478-83http://www.ncbi.nlm.nih.gov/pubmed/16938523Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis. Hum Pathol. 2006 Sep; 37(9):1176-85.Adamopoulos IE, Wordsworth PB, Edwards JR, Ferguson DJ, Athanasou NA. Hum Pathol2006 Sep37(9):1176-85http://www.ncbi.nlm.nih.gov/pubmed/16720039In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line. Biomaterials. 2006 Sep; 27(26):4557-65.Xia Z, Grover LM, Huang Y, Adamopoulos IE, Gbureck U, Triffitt JT, Shelton RM, Barralet JE. Biomaterials2006 Sep27(26):4557-65http://www.ncbi.nlm.nih.gov/pubmed/16649193LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum. 2006 May; 54(5):1451-62.Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A. Arthritis Rheum2006 May54(5):1451-62http://www.ncbi.nlm.nih.gov/pubmed/16642388Stimulation of osteoclast formation by inflammatory synovial fluid. Virchows Arch. 2006 Jul; 449(1):69-77.Adamopoulos IE, Danks L, Itonaga I, Locklin RM, Sabokbar A, Ferguson DJ, Athanasou NA. Virchows Arch2006 Jul449(1):69-77http://www.ncbi.nlm.nih.gov/pubmed/16278818Synovial fluid macrophages are capable of osteoclast formation and resorption. J Pathol. 2006 Jan; 208(1):35-43.Adamopoulos IE, Sabokbar A, Wordsworth BP, Carr A, Ferguson DJ, Athanasou NA. J Pathol2006 Jan208(1):35-43http://www.ncbi.nlm.nih.gov/pubmed/25312908Hepatocyte growth factor in normal and diseased bone and joint tissues. Curr Rheumatol Rev. 2006; 2(1):1-7.Adamopoulos IE, Athanasou NA. Curr Rheumatol Rev20062(1):1-7Osteoclasts214.584685725049812e+0002006-01-01T00:00:002025-07-07T00:00:00Interleukin-17153.405318094012306e+0002010-02-18T00:00:002024-02-01T00:00:00Bone Resorption173.092864788903871e+0002006-01-01T00:00:002025-07-07T00:00:00Arthritis, Experimental83.002524198389469e+0002010-04-12T00:00:002023-04-08T00:00:00Arthritis82.868785138798218e+0002006-04-21T00:00:002025-07-07T00:00:00Interleukin-23102.414490147898595e+0002014-01-11T00:00:002024-02-01T00:00:00Arthritis, Psoriatic41.934149245214972e+0002014-01-11T00:00:002024-02-01T00:00:00RANK Ligand161.804806138287705e+0002006-01-01T00:00:002025-07-07T00:00:00Interleukin-2721.323117960902123e+0002018-05-15T00:00:002023-04-08T00:00:00Spondylitis, Ankylosing21.213491831232477e+0002021-01-04T00:00:002021-02-18T00:00:00Trained Immunity21.061333863525710e+0002023-09-06T00:00:002025-07-07T00:00:00Psoriasis31.004347553457723e+0002022-05-22T00:00:002024-02-01T00:00:00Leukotriene B428.740528167975614e-0012014-12-02T00:00:002016-11-28T00:00:00Osteogenesis58.612428837671501e-0012006-01-01T00:00:002023-06-06T00:00:00Inflammation117.695880744010151e-0012010-03-08T00:00:002025-07-07T00:00:00Receptors, Antigen, T-Cell, gamma-delta37.571619863296000e-0012016-10-24T00:00:002022-07-21T00:00:00Dermatitis17.192225515577855e-0012024-02-01T00:00:002024-02-01T00:00:00Immune System16.061920633045811e-0012025-02-25T00:00:002025-02-25T00:00:00Arthritis, Rheumatoid95.816977138279527e-0012006-01-01T00:00:002016-11-28T00:00:00NFATC Transcription Factors25.639355791348386e-0012014-12-01T00:00:002017-12-15T00:00:00Autophagy25.471817810469544e-0012016-06-18T00:00:002016-10-24T00:00:00Chondrocalcinosis25.466935530986756e-0012006-01-01T00:00:002012-08-03T00:00:00Intermediate-Conductance Calcium-Activated Potassium Channels15.410313417929401e-0012017-12-15T00:00:002017-12-15T00:00:00Th17 Cells25.358059306366840e-0012021-02-18T00:00:002023-04-08T00:00:00Synovial Fluid45.357759764575102e-0012006-01-01T00:00:002012-08-03T00:00:00Spondylarthritis15.352334549379564e-0012019-02-18T00:00:002019-02-18T00:00:00Cell Differentiation145.275003315110104e-0012006-01-01T00:00:002023-06-06T00:00:00Bone Marrow25.144691918620871e-0012018-05-15T00:00:002025-02-25T00:00:00Receptors, Leukotriene B414.943905757928938e-0012016-11-28T00:00:002016-11-28T00:00:00Vesicular Transport Proteins24.924766026455694e-0012014-09-08T00:00:002016-06-18T00:00:00TNF Receptor-Associated Factor 614.861295971953462e-0012016-06-18T00:00:002016-06-18T00:00:00Bone and Bones34.764571094248365e-0012007-05-29T00:00:002025-02-25T00:00:00Receptors, Interleukin54.650017869303067e-0012012-11-16T00:00:002021-06-15T00:00:00Calcium Signaling24.428129692580771e-0012014-12-02T00:00:002021-06-15T00:00:00Intracellular Fluid14.330231531530274e-0012014-12-02T00:00:002014-12-02T00:00:00Neutrophils44.301045738186801e-0012014-01-11T00:00:002024-02-01T00:00:00Myeloid Progenitor Cells14.250713635709554e-0012014-12-01T00:00:002014-12-01T00:00:00Macrophages84.220422164264323e-0012006-01-01T00:00:002020-06-05T00:00:00Extracellular Traps13.902805143432548e-0012016-10-24T00:00:002016-10-24T00:00:00Immunity, Innate13.763926709686742e-0012025-07-07T00:00:002025-07-07T00:00:00Epithelium13.649593762246531e-0012016-10-24T00:00:002016-10-24T00:00:00Leukocytes, Mononuclear63.610907515503198e-0012006-04-21T00:00:002014-12-02T00:00:00Interleukin-23 Subunit p1913.515108989910848e-0012011-06-13T00:00:002011-06-13T00:00:00Epidermis13.382431142564121e-0012014-02-23T00:00:002014-02-23T00:00:00T-Lymphocyte Subsets33.150955056606833e-0012008-10-17T00:00:002020-06-05T00:00:00Lectins, C-Type33.094347394214279e-0012010-03-08T00:00:002024-02-01T00:00:00Calcium33.068650957288235e-0012014-12-01T00:00:002017-12-15T00:00:00Animals302.997667072175462e-0012006-05-01T00:00:002025-07-07T00:00:00Mice232.973705249639176e-0012006-05-01T00:00:002025-07-07T00:00:00Tartrate-Resistant Acid Phosphatase32.813828249369542e-0012006-04-21T00:00:002016-06-18T00:00:00X-Ray Microtomography22.703421214230393e-0012016-06-18T00:00:002023-06-06T00:00:00Mice, Knockout82.566712584326047e-0012010-02-18T00:00:002021-06-15T00:00:00Cells, Cultured92.498231011260447e-0012006-01-01T00:00:002017-12-15T00:00:00Histiocytosis, Non-Langerhans-Cell12.492204231299367e-0012006-07-18T00:00:002006-07-18T00:00:00Bone Remodeling12.442097883037491e-0012010-02-18T00:00:002010-02-18T00:00:00Gene Expression Regulation62.276326657111286e-0012010-02-18T00:00:002017-12-15T00:00:00Hepatocyte Growth Factor12.240991482896508e-0012006-09-25T00:00:002006-09-25T00:00:00Cytokines52.190137461023642e-0012006-05-01T00:00:002023-09-01T00:00:00Osteoarthritis22.112834455485762e-0012008-10-03T00:00:002012-08-03T00:00:00Receptors, Cell Surface32.082081767836193e-0012010-03-08T00:00:002024-02-01T00:00:00Antibodies, Monoclonal, Humanized12.037221824913244e-0012021-01-04T00:00:002021-01-04T00:00:00T-Lymphocytes, Helper-Inducer11.891485327850276e-0012008-10-17T00:00:002008-10-17T00:00:00Hyperplasia21.834651676795489e-0012014-02-23T00:00:002016-10-24T00:00:00Serine-Arginine Splicing Factors11.822799038595399e-0012022-05-22T00:00:002022-05-22T00:00:00Fibroblasts11.765114575207109e-0012012-08-03T00:00:002012-08-03T00:00:00T-Lymphocytes21.706096593901864e-0012012-11-16T00:00:002016-10-24T00:00:00HLA-B27 Antigen11.675391118251778e-0012021-01-04T00:00:002021-01-04T00:00:00RNA Splicing Factors11.655453965932212e-0012022-05-22T00:00:002022-05-22T00:00:00Osteoprotegerin31.646861444210348e-0012006-07-18T00:00:002012-08-03T00:00:00Adaptor Proteins, Signal Transducing41.608267739538697e-0012010-03-08T00:00:002016-06-18T00:00:00Gene Transfer Techniques21.562870123986912e-0012014-02-23T00:00:002016-06-18T00:00:00Acid Phosphatase21.549487672299108e-0012006-04-21T00:00:002012-08-03T00:00:00Blotting, Western21.501675915468075e-0012016-06-18T00:00:002016-11-28T00:00:00Integrin alphaVbeta321.481003230501208e-0012006-04-21T00:00:002012-08-03T00:00:00Humans331.477535756335306e-0012006-01-01T00:00:002025-07-07T00:00:00Kidney Tubules11.472724712370033e-0012021-06-15T00:00:002021-06-15T00:00:00Spleen21.451137899216351e-0012011-06-13T00:00:002018-05-15T00:00:00Proprotein Convertase 911.419451044103994e-0012022-08-22T00:00:002022-08-22T00:00:00Arginine11.417342314232931e-0012022-05-22T00:00:002022-05-22T00:00:00Serine11.403523339117996e-0012022-05-22T00:00:002022-05-22T00:00:00Interleukin-12 Receptor beta 1 Subunit11.401362661416007e-0012017-12-26T00:00:002017-12-26T00:00:00NF-kappa B21.370860420689288e-0012016-06-18T00:00:002016-11-28T00:00:00Autophagy-Related Proteins21.366072328532381e-0012014-09-08T00:00:002016-06-18T00:00:00Receptor Activator of Nuclear Factor-kappa B31.359702198415042e-0012006-01-01T00:00:002006-07-18T00:00:00Tumor Necrosis Factor-alpha51.333110703560012e-0012006-01-01T00:00:002012-08-03T00:00:00CREB-Binding Protein11.311254082696854e-0012017-12-15T00:00:002017-12-15T00:00:00Flow Cytometry31.283610771634420e-0012006-09-25T00:00:002016-11-28T00:00:00Stem Cells11.276303374476389e-0012010-02-18T00:00:002010-02-18T00:00:00Alternative Splicing11.249878901170097e-0012022-05-22T00:00:002022-05-22T00:00:00Cathepsin K11.235870592302361e-0012016-06-18T00:00:002016-06-18T00:00:00Autoantigens11.203378746187143e-0012020-06-05T00:00:002020-06-05T00:00:00Interleukins11.184288407118234e-0012021-01-04T00:00:002021-01-04T00:00:00Giant Cells11.177940929859640e-0012016-06-18T00:00:002016-06-18T00:00:00Neutrophil Infiltration11.159805743458855e-0012018-05-15T00:00:002018-05-15T00:00:00Real-Time Polymerase Chain Reaction21.147278832471792e-0012016-11-28T00:00:002017-12-26T00:00:00Autoimmunity11.145607747936510e-0012023-09-06T00:00:002023-09-06T00:00:00Proto-Oncogene Proteins c-fos11.140767803114344e-0012017-12-15T00:00:002017-12-15T00:00:00Synovial Membrane21.121840632008941e-0012008-10-03T00:00:002016-11-28T00:00:00Isoenzymes21.121374777774019e-0012006-04-21T00:00:002012-08-03T00:00:00Mice, Inbred C57BL41.102111211511437e-0012010-03-08T00:00:002022-07-21T00:00:00Up-Regulation21.085891002841072e-0012010-02-18T00:00:002016-06-18T00:00:00Phospholipase C gamma11.076594175176145e-0012014-12-01T00:00:002014-12-01T00:00:00Regeneration11.070886187004732e-0012023-09-01T00:00:002023-09-01T00:00:00Primary Cell Culture11.055324647339016e-0012016-06-18T00:00:002016-06-18T00:00:00Osteoarthritis, Knee11.039603775171626e-0012006-01-01T00:00:002006-01-01T00:00:00Intracellular Signaling Peptides and Proteins21.035688879154725e-0012013-07-25T00:00:002014-12-01T00:00:00Protein Structure, Quaternary11.016644224778499e-0012014-12-01T00:00:002014-12-01T00:00:00Syk Kinase11.000106764840350e-0012014-12-01T00:00:002014-12-01T00:00:00Matrix Metalloproteinase 919.763256608765737e-0022016-06-18T00:00:002016-06-18T00:00:00Exercise Therapy19.751389199707131e-0022021-01-04T00:00:002021-01-04T00:00:00Osteoblasts29.678674907363942e-0022010-03-08T00:00:002016-06-18T00:00:00Chromosomes, Human, Pair 619.123240479617240e-0022013-07-25T00:00:002013-07-25T00:00:00Homeostasis19.116615594307784e-0022023-09-01T00:00:002023-09-01T00:00:00Macrophage Activation18.954074667593612e-0022014-12-01T00:00:002014-12-01T00:00:00DNA, Kinetoplast18.919653472558480e-0022011-06-13T00:00:002011-06-13T00:00:00Receptors, Calcitriol18.656560390066025e-0022013-10-01T00:00:002013-10-01T00:00:00Culture Media, Conditioned18.450375570857403e-0022012-08-03T00:00:002012-08-03T00:00:00Membrane Glycoproteins38.438850298716194e-0022006-01-01T00:00:002006-07-18T00:00:00Interleukin-128.208863893868490e-0022006-01-01T00:00:002022-08-22T00:00:00Mice, 129 Strain18.193745540456393e-0022011-06-13T00:00:002011-06-13T00:00:00Microscopy, Electron, Scanning37.944987597868874e-0022006-05-23T00:00:002006-12-01T00:00:00Skin17.922368239642684e-0022024-02-01T00:00:002024-02-01T00:00:00Child Development Disorders, Pervasive17.811704417204622e-0022014-09-08T00:00:002014-09-08T00:00:00Femur17.810766153927712e-0022016-06-18T00:00:002016-06-18T00:00:00B-Lymphocytes17.697392799289833e-0022023-09-06T00:00:002023-09-06T00:00:00Membrane Proteins37.620479965527768e-0022006-05-01T00:00:002014-12-01T00:00:00Cricetulus17.564527069399472e-0022011-06-13T00:00:002011-06-13T00:00:00Enzyme Activation17.425864874408951e-0022014-12-01T00:00:002014-12-01T00:00:00Carrier Proteins37.360252661394857e-0022006-01-01T00:00:002006-07-18T00:00:00Immunohistochemistry27.267729923046190e-0022006-07-18T00:00:002016-11-28T00:00:00Protein Binding27.204838514587855e-0022017-12-15T00:00:002017-12-26T00:00:00Cleft Lip17.181033054483056e-0022013-07-25T00:00:002013-07-25T00:00:00Th1 Cells17.170324317807825e-0022013-10-01T00:00:002013-10-01T00:00:00Multiprotein Complexes17.152575961484968e-0022014-12-01T00:00:002014-12-01T00:00:00CHO Cells17.151225408904721e-0022011-06-13T00:00:002011-06-13T00:00:00Oligonucleotide Array Sequence Analysis17.146338009727996e-0022016-11-28T00:00:002016-11-28T00:00:00Signal Transduction47.136103885236297e-0022012-08-03T00:00:002017-12-26T00:00:00Calcium Phosphates27.048830996269390e-0022006-05-23T00:00:002006-12-01T00:00:00Cleft Palate16.894763493317696e-0022013-07-25T00:00:002013-07-25T00:00:00Translocation, Genetic16.767619205041611e-0022013-07-25T00:00:002013-07-25T00:00:00Neurogenesis16.747939179172061e-0022014-09-08T00:00:002014-09-08T00:00:00Cricetinae16.718452658521121e-0022011-06-13T00:00:002011-06-13T00:00:00Lupus Erythematosus, Systemic16.707356340620212e-0022020-06-05T00:00:002020-06-05T00:00:00Homeodomain Proteins16.620612023523742e-0022016-10-24T00:00:002016-10-24T00:00:00Pamidronate16.235818377144134e-0022006-07-18T00:00:002006-07-18T00:00:00Macrophage Colony-Stimulating Factor15.990375312026561e-0022006-09-25T00:00:002006-09-25T00:00:00Protein-Tyrosine Kinases15.828480188918746e-0022014-12-01T00:00:002014-12-01T00:00:00Polyglycolic Acid15.731931924054416e-0022006-12-01T00:00:002006-12-01T00:00:00Actins15.675825106080323e-0022012-08-03T00:00:002012-08-03T00:00:00Methylprednisolone15.513028967700200e-0022006-07-18T00:00:002006-07-18T00:00:00Microscopy, Electron, Transmission15.401596139951848e-0022006-07-18T00:00:002006-07-18T00:00:00Cell Separation15.364922166414338e-0022010-02-18T00:00:002010-02-18T00:00:00Bone Cements15.329187566363182e-0022006-05-23T00:00:002006-05-23T00:00:00Vitamin D Deficiency15.283496704252052e-0022013-10-01T00:00:002013-10-01T00:00:00Lipopolysaccharide Receptors15.263939886107115e-0022006-01-01T00:00:002006-01-01T00:00:00Receptors, Tumor Necrosis Factor15.200357927710987e-0022006-07-18T00:00:002006-07-18T00:00:00Autoimmune Diseases25.145952456971753e-0022010-03-08T00:00:002013-10-01T00:00:00Phosphorylation15.109809410166045e-0022014-12-01T00:00:002014-12-01T00:00:00Male124.833109613482167e-0022006-01-01T00:00:002018-05-15T00:00:00Mice, Transgenic24.736103737616973e-0022011-06-13T00:00:002014-09-08T00:00:00Interleukin-614.681953142423404e-0022012-08-03T00:00:002012-08-03T00:00:00Subtilisins14.667191286831897e-0022022-08-22T00:00:002022-08-22T00:00:00Cell Movement14.662055877284652e-0022014-09-08T00:00:002014-09-08T00:00:00Proto-Oncogene Proteins c-met14.655159994127057e-0022006-09-25T00:00:002006-09-25T00:00:00Receptors, Cytoplasmic and Nuclear14.549909683211465e-0022006-07-18T00:00:002006-07-18T00:00:00HEK293 Cells14.492580282551172e-0022011-06-13T00:00:002011-06-13T00:00:00Proprotein Convertases14.468151492630453e-0022022-08-22T00:00:002022-08-22T00:00:00Sarcoma, Ewing14.467880114597798e-0022007-05-29T00:00:002007-05-29T00:00:00Lactic Acid14.406787956475156e-0022006-12-01T00:00:002006-12-01T00:00:00Transcriptome14.380027823855906e-0022016-11-28T00:00:002016-11-28T00:00:00Diphosphonates14.362511391637707e-0022006-07-18T00:00:002006-07-18T00:00:00Arginase14.237495152802032e-0022021-06-15T00:00:002021-06-15T00:00:00Calcium-Calmodulin-Dependent Protein Kinase Type 414.223632490664756e-0022021-06-15T00:00:002021-06-15T00:00:00Vitamin D13.974248471574840e-0022013-10-01T00:00:002013-10-01T00:00:00Cell Survival23.952974872078395e-0022006-09-25T00:00:002006-12-01T00:00:00Polymers13.771424788689470e-0022006-12-01T00:00:002006-12-01T00:00:00Disease Models, Animal23.677506262797099e-0022014-02-23T00:00:002020-06-05T00:00:00Glycoproteins13.615420821540991e-0022006-07-18T00:00:002006-07-18T00:00:00Nuclear Proteins13.576865900022177e-0022013-07-25T00:00:002013-07-25T00:00:00Cerebral Cortex13.497753536577543e-0022014-09-08T00:00:002014-09-08T00:00:00Ki-67 Antigen13.440057785358245e-0022020-06-05T00:00:002020-06-05T00:00:00Interleukin-12 Subunit p4013.437534911462267e-0022017-12-26T00:00:002017-12-26T00:00:00Calorimetry13.423496640990284e-0022017-12-26T00:00:002017-12-26T00:00:00Biocompatible Materials13.384171764693963e-0022006-05-23T00:00:002006-05-23T00:00:00Gene Expression13.357317307046569e-0022010-02-18T00:00:002010-02-18T00:00:00Skin Diseases13.342848590517762e-0022006-07-18T00:00:002006-07-18T00:00:00Interferometry13.335235232481239e-0022017-12-26T00:00:002017-12-26T00:00:00Adoptive Transfer13.329411517744720e-0022020-06-05T00:00:002020-06-05T00:00:00Serine Endopeptidases13.272604275214332e-0022022-08-22T00:00:002022-08-22T00:00:00Knee Joint13.193182541201042e-0022006-01-01T00:00:002006-01-01T00:00:00Monocytes13.183854887599624e-0022006-09-25T00:00:002006-09-25T00:00:00Anti-Inflammatory Agents13.142481568022188e-0022006-07-18T00:00:002006-07-18T00:00:00Antibodies, Monoclonal23.116054677775747e-0022010-03-08T00:00:002010-10-07T00:00:00Receptors, Antigen, T-Cell, alpha-beta13.101504731653679e-0022020-06-05T00:00:002020-06-05T00:00:00Chronic Disease13.058328290789919e-0022011-06-13T00:00:002011-06-13T00:00:00Bone Neoplasms12.692504575287450e-0022007-05-29T00:00:002007-05-29T00:00:00Chromosome Breakpoints12.506655189237966e-0022013-07-25T00:00:002013-07-25T00:00:00Cell Line32.492290335504260e-0022006-05-23T00:00:002017-12-26T00:00:00Severity of Illness Index12.465373262297533e-0022011-06-13T00:00:002011-06-13T00:00:00Magnetic Resonance Imaging12.441558476094440e-0022021-01-04T00:00:002021-01-04T00:00:00Diet Therapy12.339108622045156e-0022013-10-01T00:00:002013-10-01T00:00:00DNA-Binding Proteins12.191048122696120e-0022008-10-03T00:00:002008-10-03T00:00:00Immune Tolerance12.112688687460871e-0022020-06-05T00:00:002020-06-05T00:00:00Cell Proliferation12.072562593094139e-0022006-09-25T00:00:002006-09-25T00:00:00Tomography, X-Ray Computed21.918225583304631e-0022010-02-18T00:00:002010-04-12T00:00:00Histocytochemistry11.845669007594965e-0022010-04-12T00:00:002010-04-12T00:00:00Disease Progression21.824133313122774e-0022010-10-07T00:00:002020-06-05T00:00:00Homozygote11.801344497486316e-0022013-07-25T00:00:002013-07-25T00:00:00Mutation11.786515678359527e-0022013-07-25T00:00:002013-07-25T00:00:00Protein Isoforms11.774521283161873e-0022013-07-25T00:00:002013-07-25T00:00:00Joints11.745648229439837e-0022010-10-07T00:00:002010-10-07T00:00:00Phenotype11.683433792684193e-0022006-01-01T00:00:002006-01-01T00:00:00HLA-DRB1 Chains11.671126030610258e-0022008-10-03T00:00:002008-10-03T00:00:00Mice, Inbred Strains11.659693196392684e-0022010-03-08T00:00:002010-03-08T00:00:00HLA-DR Antigens11.579416962211008e-0022008-10-03T00:00:002008-10-03T00:00:00Tumor Necrosis Factor Ligand Superfamily Member 1411.561058267152413e-0022006-05-01T00:00:002006-05-01T00:00:00Joint Diseases11.512992253918717e-0022010-03-08T00:00:002010-03-08T00:00:00TNF-Related Apoptosis-Inducing Ligand11.501687192019232e-0022007-05-29T00:00:002007-05-29T00:00:00Biodegradation, Environmental11.489789013829105e-0022006-05-23T00:00:002006-05-23T00:00:00Polylactic Acid-Polyglycolic Acid Copolymer11.476763493452543e-0022006-12-01T00:00:002006-12-01T00:00:00Foot11.476152148854043e-0022010-04-12T00:00:002010-04-12T00:00:00Major Histocompatibility Complex11.473239922201790e-0022008-10-03T00:00:002008-10-03T00:00:00Immunoenzyme Techniques11.455429500184052e-0022008-10-03T00:00:002008-10-03T00:00:00Solvents11.453467052127905e-0022006-12-01T00:00:002006-12-01T00:00:00Chromosome Mapping11.427707538215681e-0022013-07-25T00:00:002013-07-25T00:00:00Cell Lineage11.338827491598982e-0022013-10-01T00:00:002013-10-01T00:00:00Models, Animal11.331215691798509e-0022010-10-07T00:00:002010-10-07T00:00:00Aged31.327100708643661e-0022006-01-01T00:00:002007-05-29T00:00:00Rats21.319916267318779e-0022010-04-12T00:00:002010-10-07T00:00:00Female51.294197827627708e-0022006-01-01T00:00:002020-06-05T00:00:00Calcium-Binding Proteins11.290812722701626e-0022008-10-03T00:00:002008-10-03T00:00:00Linkage Disequilibrium11.289200904786728e-0022008-10-03T00:00:002008-10-03T00:00:00Polymorphism, Genetic11.258677037116872e-0022013-10-01T00:00:002013-10-01T00:00:00Microfilament Proteins11.257635035732701e-0022008-10-03T00:00:002008-10-03T00:00:00Adult31.223698791107795e-0022006-07-18T00:00:002007-05-29T00:00:00Middle Aged31.187841938983329e-0022006-01-01T00:00:002007-05-29T00:00:00Bone Marrow Cells11.187201412583265e-0022010-03-08T00:00:002010-03-08T00:00:00Alleles11.159464379260713e-0022013-07-25T00:00:002013-07-25T00:00:00Amino Acid Sequence11.138305509489392e-0022013-07-25T00:00:002013-07-25T00:00:00Polymorphism, Single Nucleotide21.120494145332884e-0022008-10-03T00:00:002013-07-25T00:00:00Stromal Cells11.117082463909907e-0022007-05-29T00:00:002007-05-29T00:00:00Reverse Transcriptase Polymerase Chain Reaction11.104719143620168e-0022008-10-03T00:00:002008-10-03T00:00:00Molecular Sequence Data11.067263340915758e-0022013-07-25T00:00:002013-07-25T00:00:00Microscopy11.054433443665694e-0022006-05-23T00:00:002006-05-23T00:00:00Killer Cells, Natural11.023313714525901e-0022010-03-08T00:00:002010-03-08T00:00:00Tumor Cells, Cultured19.755826327095441e-0032007-05-29T00:00:002007-05-29T00:00:00Genetic Predisposition to Disease29.422721187449553e-0032008-10-03T00:00:002013-10-01T00:00:00Genotype16.607622251176515e-0032008-10-03T00:00:002008-10-03T00:00:00Case-Control Studies15.198122641601429e-0032008-10-03T00:00:002008-10-03T00:00:00Models, Biological14.998308409605884e-0032006-05-23T00:00:002006-05-23T00:00:00Biomarkers14.286212250500318e-0032010-04-12T00:00:002010-04-12T00:00:00Adolescent12.215815653586969e-0032007-05-29T00:00:002007-05-29T00:00:00Austin Adams, M.D.AustinAdams

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterEmergency MedicineClinical Fellow in Emergency MedicineFellow or Post DocGifty Addae, M.D.GiftyAddae

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-5086

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/37577160Implementing Telemedicine During the COVID-19 Pandemic: Disparities in Utilization in an Urban Pain Medicine Practice. J Pain Res. 2023; 16:2763-2775.Rockholt MM, Addae G, Chee A, Chin W, Cuff G, Wang J, Umeh UO, Doan LV. J Pain Res202316:2763-2775http://www.ncbi.nlm.nih.gov/pubmed/31100719Long-term clinical and visual outcomes after surgical resection of pediatric pilocytic/pilomyxoid optic pathway gliomas. J Neurosurg Pediatr. 2019 08 01; 24(2):166-173.Hidalgo ET, Kvint S, Orillac C, North E, Dastagirzada Y, Chang JC, Addae G, Jennings TS, Snuderl M, Wisoff JH. J Neurosurg Pediatr2019 08 0124(2):166-173http://www.ncbi.nlm.nih.gov/pubmed/29034529Reliability of muscle blood flow and oxygen consumption response from exercise using near-infrared spectroscopy. Exp Physiol. 2018 01 01; 103(1):90-100.Lucero AA, Addae G, Lawrence W, Neway B, Credeur DP, Faulkner J, Rowlands D, Stoner L. Exp Physiol2018 01 01103(1):90-100http://www.ncbi.nlm.nih.gov/pubmed/28301075Clinical performance of high-resolution late gadolinium enhancement imaging with compressed sensing. J Magn Reson Imaging. 2017 12; 46(6):1829-1838.Basha TA, Akçakaya M, Liew C, Tsao CW, Delling FN, Addae G, Ngo L, Manning WJ, Nezafat R. J Magn Reson Imaging2017 1246(6):1829-1838http://www.ncbi.nlm.nih.gov/pubmed/28152237Native T1 value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction. J Magn Reson Imaging. 2017 10; 46(4):1073-1081.Nakamori S, Alakbarli J, Bellm S, Motiwala SR, Addae G, Manning WJ, Nezafat R. J Magn Reson Imaging2017 1046(4):1073-1081http://www.ncbi.nlm.nih.gov/pubmed/27930912Poor sleep quality, antepartum depression and suicidal ideation among pregnant women. J Affect Disord. 2017 Feb; 209:195-200.Gelaye B, Addae G, Neway B, Larrabure-Torrealva GT, Qiu C, Stoner L, Luque Fernandez MA, Sanchez SE, Williams MA. J Affect Disord2017 Feb209:195-200Regional Blood Flow11.051088858311318e-0012017-11-22T00:00:002017-11-22T00:00:00Spectroscopy, Near-Infrared19.493816533426799e-0022017-11-22T00:00:002017-11-22T00:00:00Gadolinium19.104017171919808e-0022017-03-16T00:00:002017-03-16T00:00:00Pregnant People18.817903181091040e-0022016-11-18T00:00:002016-11-18T00:00:00Oxygen Consumption18.516496093988793e-0022017-11-22T00:00:002017-11-22T00:00:00Heart26.417801449414494e-0022017-02-02T00:00:002017-03-16T00:00:00Image Enhancement16.159431604949073e-0022017-03-16T00:00:002017-03-16T00:00:00Ventricular Dysfunction, Left16.041792052049871e-0022017-02-02T00:00:002017-02-02T00:00:00Suicidal Ideation15.925182646239580e-0022016-11-18T00:00:002016-11-18T00:00:00Sleep Wake Disorders15.726797593622180e-0022016-11-18T00:00:002016-11-18T00:00:00Depressive Disorder15.308144471648855e-0022016-11-18T00:00:002016-11-18T00:00:00Heart Diseases15.180730312021730e-0022017-03-16T00:00:002017-03-16T00:00:00Contrast Media15.054829992004022e-0022017-03-16T00:00:002017-03-16T00:00:00Pregnancy Complications14.655450443043666e-0022016-11-18T00:00:002016-11-18T00:00:00Muscle, Skeletal14.622968046420753e-0022017-11-22T00:00:002017-11-22T00:00:00Exercise14.096252649819114e-0022017-11-22T00:00:002017-11-22T00:00:00Image Processing, Computer-Assisted13.915000984318338e-0022017-03-16T00:00:002017-03-16T00:00:00Magnetic Resonance Imaging23.736022236401659e-0022017-02-02T00:00:002017-03-16T00:00:00Depression13.052288119077034e-0022016-11-18T00:00:002016-11-18T00:00:00Myocardial Infarction13.028731367074741e-0022017-02-02T00:00:002017-02-02T00:00:00Time12.823467689406911e-0022017-02-02T00:00:002017-02-02T00:00:00Peru12.540663402088510e-0022016-11-18T00:00:002016-11-18T00:00:00Heart Ventricles11.339477478428106e-0022017-02-02T00:00:002017-02-02T00:00:00Image Interpretation, Computer-Assisted11.293176959058927e-0022017-03-16T00:00:002017-03-16T00:00:00Imaging, Three-Dimensional11.240307718020885e-0022017-03-16T00:00:002017-03-16T00:00:00Prospective Studies21.144284962881775e-0022017-02-02T00:00:002017-03-16T00:00:00Adult41.129717338583593e-0022016-11-18T00:00:002017-11-22T00:00:00Aged, 80 and over21.066600532532887e-0022017-02-02T00:00:002017-03-16T00:00:00Young Adult29.933789687347178e-0032017-03-16T00:00:002017-11-22T00:00:00Reproducibility of Results19.461874670075806e-0032017-11-22T00:00:002017-11-22T00:00:00Prevalence19.399935041610226e-0032016-11-18T00:00:002016-11-18T00:00:00Severity of Illness Index19.113500068781111e-0032017-02-02T00:00:002017-02-02T00:00:00Adolescent28.953698969390838e-0032017-03-16T00:00:002017-11-22T00:00:00Female48.317657185505008e-0032016-11-18T00:00:002017-11-22T00:00:00Cross-Sectional Studies16.947753025829202e-0032016-11-18T00:00:002016-11-18T00:00:00Surveys and Questionnaires16.857399803487374e-0032016-11-18T00:00:002016-11-18T00:00:00Pregnancy16.830498530913512e-0032016-11-18T00:00:002016-11-18T00:00:00Male36.649670110262232e-0032017-02-02T00:00:002017-11-22T00:00:00Cohort Studies16.424884148279009e-0032016-11-18T00:00:002016-11-18T00:00:00Aged26.256088989939711e-0032017-02-02T00:00:002017-03-16T00:00:00Humans45.784860700709826e-0032016-11-18T00:00:002017-11-22T00:00:00Middle Aged25.599608852486568e-0032017-02-02T00:00:002017-03-16T00:00:00Risk Factors14.691566963169132e-0032016-11-18T00:00:002016-11-18T00:00:00Jacob Adelman, M.D.JacobAdelman

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/754-2339

1BIDMCBeth Israel Deaconess Medical CenterEmergency MedicineClinical Fellow in Emergency MedicineFellow or Post DocQuadri Adedamola Adewale, Ph.D.QuadriAdewale

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterPathologyResearch Fellow in PathologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/39952947Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson's disease. NPJ Parkinsons Dis. 2025 Feb 15; 11(1):29.Adewale Q, Khan AF, Lin SJ, Baumeister TR, Zeighami Y, Carbonell F, Ferreira D, Iturria-Medina Y. NPJ Parkinsons Dis2025 Feb 1511(1):29http://www.ncbi.nlm.nih.gov/pubmed/38966801In-vivo neuronal dysfunction by Aß and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer's disease. Front Aging Neurosci. 2024; 16:1383163.Sanchez-Rodriguez LM, Khan AF, Adewale Q, Bezgin G, Therriault J, Fernandez-Arias J, Servaes S, Rahmouni N, Tissot C, Stevenson J, Jiang H, Chai X, Carbonell F, Rosa-Neto P, Iturria-Medina Y. Front Aging Neurosci202416:1383163http://www.ncbi.nlm.nih.gov/pubmed/38538816Single-nucleus RNA velocity reveals critical synaptic and cell-cycle dysregulations in neuropathologically confirmed Alzheimer's disease. Sci Rep. 2024 03 27; 14(1):7269.Adewale Q, Khan AF, Bennett DA, Iturria-Medina Y. Sci Rep2024 03 2714(1):7269http://www.ncbi.nlm.nih.gov/pubmed/38512130Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions. Elife. 2024 Mar 21; 12.Pak V, Adewale Q, Bzdok D, Dadar M, Zeighami Y, Iturria-Medina Y. Elife2024 Mar 2112http://www.ncbi.nlm.nih.gov/pubmed/37752107Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease. Nat Commun. 2023 09 26; 14(1):6009.Khan AF, Adewale Q, Lin SJ, Baumeister TR, Zeighami Y, Carbonell F, Palomero-Gallagher N, Iturria-Medina Y. Nat Commun2023 09 2614(1):6009http://www.ncbi.nlm.nih.gov/pubmed/36399579Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity. Sci Adv. 2022 11 16; 8(46):eabo6764.Iturria-Medina Y, Adewale Q, Khan AF, Ducharme S, Rosa-Neto P, O'Donnell K, Petyuk VA, Gauthier S, De Jager PL, Breitner J, Bennett DA. Sci Adv2022 11 168(46):eabo6764http://www.ncbi.nlm.nih.gov/pubmed/34605898Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease. Brain. 2022 06 03; 145(5):1785-1804.Khan AF, Adewale Q, Baumeister TR, Carbonell F, Zilles K, Palomero-Gallagher N, Iturria-Medina Y. Brain2022 06 03145(5):1785-1804http://www.ncbi.nlm.nih.gov/pubmed/34021244Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box. Commun Biol. 2021 05 21; 4(1):614.Iturria-Medina Y, Carbonell F, Assadi A, Adewale Q, Khan AF, Baumeister TR, Sanchez-Rodriguez L. Commun Biol2021 05 214(1):614http://www.ncbi.nlm.nih.gov/pubmed/34002691Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease. Elife. 2021 05 18; 10.Adewale Q, Khan AF, Carbonell F, Iturria-Medina Y. Elife2021 05 1810http://www.ncbi.nlm.nih.gov/pubmed/31989163Blood and brain gene expression trajectories mirror neuropathology and clinical deterioration in neurodegeneration. Brain. 2020 02 01; 143(2):661-673.Iturria-Medina Y, Khan AF, Adewale Q, Shirazi AH. Brain2020 02 01143(2):661-673Alzheimer Disease54.448966128962487e-0012020-02-01T00:00:002024-03-27T00:00:00Transcriptome43.430783749713129e-0012021-05-18T00:00:002024-03-27T00:00:00Cognitive Dysfunction22.511513978460047e-0012021-05-18T00:00:002022-06-03T00:00:00Solitary Nucleus12.068958063936252e-0012024-03-27T00:00:002024-03-27T00:00:00Aging11.760313103292805e-0012021-05-18T00:00:002021-05-18T00:00:00Clinical Deterioration11.515610596691731e-0012020-02-01T00:00:002020-02-01T00:00:00Parkinson Disease21.513741217412057e-0012023-09-26T00:00:002024-03-21T00:00:00Atrophy11.201519263834348e-0012021-05-18T00:00:002021-05-18T00:00:00Neuroimaging31.123981564278281e-0012021-05-21T00:00:002023-09-26T00:00:00Neurodegenerative Diseases11.076195247695328e-0012024-03-21T00:00:002024-03-21T00:00:00RNA11.056371724946643e-0012024-03-27T00:00:002024-03-27T00:00:00Models, Neurological19.899552545235897e-0022021-05-18T00:00:002021-05-18T00:00:00tau Proteins29.756956414068344e-0022021-05-18T00:00:002022-06-03T00:00:00Huntington Disease19.622331372274372e-0022020-02-01T00:00:002020-02-01T00:00:00Receptors, Neurotransmitter29.542534508067621e-0022022-06-03T00:00:002023-09-26T00:00:00Brain59.248802911785214e-0022020-02-01T00:00:002024-03-21T00:00:00Brain Diseases18.952390905332633e-0022021-05-21T00:00:002021-05-21T00:00:00Amyloid beta-Peptides28.450921682144763e-0022021-05-18T00:00:002022-06-03T00:00:00Glucose17.672571440003434e-0022021-05-18T00:00:002021-05-18T00:00:00Computational Biology17.241686648280019e-0022021-05-21T00:00:002021-05-21T00:00:00Nerve Tissue Proteins17.097002576302559e-0022021-05-21T00:00:002021-05-21T00:00:00Positron-Emission Tomography26.858576827657675e-0022021-05-18T00:00:002022-06-03T00:00:00Gene Expression Profiling16.796762566747412e-0022024-03-27T00:00:002024-03-27T00:00:00Software16.377345763105481e-0022021-05-21T00:00:002021-05-21T00:00:00Epigenomics26.004016391776422e-0022021-05-21T00:00:002022-11-16T00:00:00Gene Expression Regulation14.584372327446720e-0022020-02-01T00:00:002020-02-01T00:00:00Disease Progression33.897321385463731e-0022020-02-01T00:00:002022-11-16T00:00:00Magnetic Resonance Imaging23.177500065831176e-0022021-05-18T00:00:002022-06-03T00:00:00Dopamine13.083055594784620e-0022023-09-26T00:00:002023-09-26T00:00:00Humans82.954688196900020e-0022020-02-01T00:00:002024-03-27T00:00:00Early Diagnosis12.740478934461812e-0022020-02-01T00:00:002020-02-01T00:00:00Aged22.128330284942337e-0022021-05-18T00:00:002022-06-03T00:00:00Proteome12.052384836272790e-0022021-05-21T00:00:002021-05-21T00:00:00Brain Mapping11.838000645037597e-0022024-03-21T00:00:002024-03-21T00:00:00Proteomics11.769709015262094e-0022022-11-16T00:00:002022-11-16T00:00:00Gene Expression11.673093018477945e-0022020-02-01T00:00:002020-02-01T00:00:00Cerebral Cortex11.637265536033371e-0022023-09-26T00:00:002023-09-26T00:00:00Neurons11.329136018025673e-0022024-03-21T00:00:002024-03-21T00:00:00Algorithms19.301462746161745e-0032020-02-01T00:00:002020-02-01T00:00:00Jaime Lauren Adler, M.D.JaimeAdler

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/754-2339

1BIDMCBeth Israel Deaconess Medical CenterEmergency MedicineInstructor in Emergency MedicineInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/35182916Assessing resident and attending error and adverse events in the emergency department. Am J Emerg Med. 2022 Apr; 54:228-231.Adler JL, Gurley K, Rosen CL, Wolfe RE, Grossman SA. Am J Emerg Med2022 Apr54:228-231Emergency Medicine13.711013485830391e-0012022-01-23T00:00:002022-01-23T00:00:00Internship and Residency11.738689856190135e-0012022-01-23T00:00:002022-01-23T00:00:00Emergency Service, Hospital14.416844055344002e-0022022-01-23T00:00:002022-01-23T00:00:00Humans18.062611069331101e-0032022-01-23T00:00:002022-01-23T00:00:00Jonah Adler, M.D.JonahAdler

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post DocSouheil Adra, M.D.SouheilAdra

Beth Israel Deaconess Hospital - MiltonCenter for Specialty Care199 Reedsdale RoadMilton, MA 02186617/313-1450

1BIDMCBeth Israel Deaconess Medical CenterSurgeryInstructor in Surgery, Part-timeInstructorhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=1248340http://www.ncbi.nlm.nih.gov/pubmed/40420550Battle of the Bots: Assessing the Ability of Four Large Language Models to Tackle Different Surgery Topics. Am Surg. 2026 Jan; 92(1):48-52.Madi M, Araji T, Hazimeh D, Adra SW. Am Surg2026 Jan92(1):48-52http://www.ncbi.nlm.nih.gov/pubmed/38215308Impact of COVID-19 Pandemic Surge on Surgical Outcomes: A Retrospective Study. Am Surg. 2024 Jun; 90(6):1224-1233.Yoshida T, Chude-Sokei R, Araji T, Adra S. Am Surg2024 Jun90(6):1224-1233http://www.ncbi.nlm.nih.gov/pubmed/38070261A Narrative Review on Intraoperative Adverse Events: Risks, Prevention, and Mitigation. J Surg Res. 2024 03; 295:468-476.Kawa N, Araji T, Kaafarani H, Adra SW. J Surg Res2024 03295:468-476http://www.ncbi.nlm.nih.gov/pubmed/35947198Gamification of robotic simulation to train general surgery residents. Surg Endosc. 2023 04; 37(4):3136-3144.Nakamoto K, Jones DB, Adra SW. Surg Endosc2023 0437(4):3136-3144http://www.ncbi.nlm.nih.gov/pubmed/24619331A comparison of NOTES transvaginal and laparoscopic cholecystectomy procedures based upon task analysis. Surg Endosc. 2014 Aug; 28(8):2443-51.Nemani A, Sankaranarayanan G, Olasky JS, Adra S, Roberts KE, Panait L, Schwaitzberg SD, Jones DB, De S. Surg Endosc2014 Aug28(8):2443-51http://www.ncbi.nlm.nih.gov/pubmed/23111040General surgery vs fellowship: the role of the Independent Academic Medical Center. J Surg Educ. 2012 Nov-Dec; 69(6):740-5.Adra SW, Trickey AW, Crosby ME, Kurtzman SH, Friedell ML, Reines HD. J Surg Educ2012 Nov-Dec69(6):740-5Specialties, Surgical16.564536777105846e-0012025-05-26T00:00:002025-05-26T00:00:00General Surgery25.851913161546167e-0012012-06-23T00:00:002025-05-26T00:00:00Intraoperative Complications25.251555967951361e-0012014-03-12T00:00:002023-12-08T00:00:00Robotics14.670513387266478e-0012022-08-10T00:00:002022-08-10T00:00:00Social Media14.512944468788912e-0012025-05-26T00:00:002025-05-26T00:00:00Language14.391054814479242e-0012025-05-26T00:00:002025-05-26T00:00:00Robotic Surgical Procedures13.875858349024152e-0012022-08-10T00:00:002022-08-10T00:00:00Surgical Procedures, Operative13.682464952097659e-0012024-01-12T00:00:002024-01-12T00:00:00Surgeons13.432029193195555e-0012023-12-08T00:00:002023-12-08T00:00:00Career Choice12.348670534556087e-0012012-06-23T00:00:002012-06-23T00:00:00Postoperative Complications22.056302925172902e-0012023-12-08T00:00:002024-01-12T00:00:00Large Language Models12.037965657494175e-0012025-05-26T00:00:002025-05-26T00:00:00Fellowships and Scholarships11.961114252535482e-0012012-06-23T00:00:002012-06-23T00:00:00Gamification11.925319836202590e-0012022-08-10T00:00:002022-08-10T00:00:00Academic Medical Centers11.798391194233847e-0012012-06-23T00:00:002012-06-23T00:00:00Operative Time21.777631352083779e-0012014-03-12T00:00:002024-01-12T00:00:00Academies and Institutes11.561308731265845e-0012022-08-10T00:00:002022-08-10T00:00:00Operating Rooms11.324773052554029e-0012023-12-08T00:00:002023-12-08T00:00:00COVID-1911.011196576839931e-0012024-01-12T00:00:002024-01-12T00:00:00Reoperation19.494686916109950e-0022024-01-12T00:00:002024-01-12T00:00:00Interrupted Time Series Analysis19.378290453110449e-0022014-03-12T00:00:002014-03-12T00:00:00Gallbladder19.285148212273689e-0022014-03-12T00:00:002014-03-12T00:00:00Natural Orifice Endoscopic Surgery19.025519752300287e-0022014-03-12T00:00:002014-03-12T00:00:00Cholecystectomy, Laparoscopic18.960926327907336e-0022014-03-12T00:00:002014-03-12T00:00:00Computer Simulation17.301717214539194e-0022022-08-10T00:00:002022-08-10T00:00:00Vagina16.893858965258115e-0022014-03-12T00:00:002014-03-12T00:00:00Pandemics15.222578737866693e-0022024-01-12T00:00:002024-01-12T00:00:00SARS-CoV-214.482408910706347e-0022024-01-12T00:00:002024-01-12T00:00:00Humans64.227269300756038e-0022012-06-23T00:00:002025-05-26T00:00:00United States24.141470012744064e-0022012-06-23T00:00:002024-01-12T00:00:00Risk Factors13.059746488238359e-0022023-12-08T00:00:002023-12-08T00:00:00Retrospective Studies12.670194674947975e-0022024-01-12T00:00:002024-01-12T00:00:00Electrosurgery12.555816393988763e-0022014-03-12T00:00:002014-03-12T00:00:00Endoscopes12.424415979288916e-0022014-03-12T00:00:002014-03-12T00:00:00Videotape Recording12.365808290065465e-0022014-03-12T00:00:002014-03-12T00:00:00Female32.093266193405717e-0022012-06-23T00:00:002024-01-12T00:00:00Male22.034163365945983e-0022012-06-23T00:00:002024-01-12T00:00:00Surveys and Questionnaires12.021201773322964e-0022012-06-23T00:00:002012-06-23T00:00:00Aged12.016169834252475e-0022024-01-12T00:00:002024-01-12T00:00:00Adult11.804724012112759e-0022024-01-12T00:00:002024-01-12T00:00:00Middle Aged11.804603877942173e-0022024-01-12T00:00:002024-01-12T00:00:00Karin Adrai, M.U.Dr.KarinAdrai

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/33631660Assessment of blood distribution in response to post-surgical steal syndrome: A novel technique based on Thermo-Anatomical Segmentation. J Biomech. 2021 04 15; 119:110304.Ovadia-Blechman Z, Hoffer O, Halak M, Adrai K, Zimmer Y, Silverberg D, Rabin N. J Biomech2021 04 15119:110304Arteriovenous Shunt, Surgical11.262905370796948e-0012021-02-12T00:00:002021-02-12T00:00:00Vascular Diseases19.486944745924587e-0022021-02-12T00:00:002021-02-12T00:00:00Fingers13.392576591063521e-0022021-02-12T00:00:002021-02-12T00:00:00Hand12.823976452892996e-0022021-02-12T00:00:002021-02-12T00:00:00Renal Dialysis12.157092215673313e-0022021-02-12T00:00:002021-02-12T00:00:00Treatment Outcome16.427470129199921e-0032021-02-12T00:00:002021-02-12T00:00:00Humans11.887911684475730e-0032021-02-12T00:00:002021-02-12T00:00:00Sanjana Adurty, M.D.SanjanaAdurty

Beth Israel Deaconess Medical CenterDivision: Adm-House Staff330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterMedicineAdm-House StaffClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/36967425Management and outcomes of women with antiphospholipid syndrome during pregnancy. J Thromb Thrombolysis. 2023 May; 55(4):751-759.Tao JJ, Adurty S, D'Angelo D, DeSancho MT. J Thromb Thrombolysis2023 May55(4):751-759http://www.ncbi.nlm.nih.gov/pubmed/35705896TSABL: Trait Specific Annotation Based Locus predictor. BMC Genomics. 2022 Jun 15; 23(1):444.Lorenz K, Thom CS, Adurty S, Voight BF. BMC Genomics2022 Jun 1523(1):444http://www.ncbi.nlm.nih.gov/pubmed/34963127Association of Gestational Age at Coronavirus Disease 2019 (COVID-19) Vaccination, History of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection, and a Vaccine Booster Dose With Maternal and Umbilical Cord Antibody Levels at Delivery. Obstet Gynecol. 2022 03 01; 139(3):373-380.Yang YJ, Murphy EA, Singh S, Sukhu AC, Wolfe I, Adurty S, Eng D, Yee J, Mohammed I, Zhao Z, Riley LE, Prabhu M. Obstet Gynecol2022 03 01139(3):373-380Antiphospholipid Syndrome11.743169731408738e-0012023-03-27T00:00:002023-03-27T00:00:00Fetal Blood11.133975213997911e-0012022-03-01T00:00:002022-03-01T00:00:00Pre-Eclampsia11.020700436555230e-0012023-03-27T00:00:002023-03-27T00:00:00Premature Birth18.557520271980172e-0022023-03-27T00:00:002023-03-27T00:00:00Lupus Erythematosus, Systemic18.147593231638309e-0022023-03-27T00:00:002023-03-27T00:00:00Immunoglobulin G18.047547636786330e-0022022-03-01T00:00:002022-03-01T00:00:00Antibodies, Viral18.008590585357613e-0022022-03-01T00:00:002022-03-01T00:00:00Thrombosis17.337714694078351e-0022023-03-27T00:00:002023-03-27T00:00:00Pregnancy Complications17.230533736877867e-0022023-03-27T00:00:002023-03-27T00:00:00COVID-19 Vaccines16.766041408230027e-0022022-03-01T00:00:002022-03-01T00:00:00Genomics15.897481170082222e-0022022-06-15T00:00:002022-06-15T00:00:00Lupus Coagulation Inhibitor14.919818182217019e-0022023-03-27T00:00:002023-03-27T00:00:00Genome-Wide Association Study14.806876474144401e-0022022-06-15T00:00:002022-06-15T00:00:00Heparin, Low-Molecular-Weight14.230738227723888e-0022023-03-27T00:00:002023-03-27T00:00:00SARS-CoV-213.938244937853139e-0022022-03-01T00:00:002022-03-01T00:00:00Immunization, Secondary13.600018418994528e-0022022-03-01T00:00:002022-03-01T00:00:00Pregnancy Outcome12.256601538504276e-0022023-03-27T00:00:002023-03-27T00:00:00COVID-1912.221093545483079e-0022022-03-01T00:00:002022-03-01T00:00:00Aspirin12.167655386787789e-0022023-03-27T00:00:002023-03-27T00:00:00Pregnancy22.045866295477403e-0022022-03-01T00:00:002023-03-27T00:00:00Models, Statistical11.700374632201886e-0022022-06-15T00:00:002022-06-15T00:00:00Phenotype11.316385026020650e-0022022-06-15T00:00:002022-06-15T00:00:00Retrospective Studies21.218191688431176e-0022022-03-01T00:00:002023-03-27T00:00:00Polymorphism, Single Nucleotide11.208790385542205e-0022022-06-15T00:00:002022-06-15T00:00:00Infant, Newborn11.177750917770970e-0022023-03-27T00:00:002023-03-27T00:00:00Female26.061983164294502e-0032022-03-01T00:00:002023-03-27T00:00:00Humans24.216058367565761e-0032022-03-01T00:00:002023-03-27T00:00:00Adult13.964076764587879e-0032022-03-01T00:00:002022-03-01T00:00:00Nezam Hassan Afdhal, M.D.NezamAfdhal

Beth Israel Deaconess Medical CenterLiver Research Ctr - Suite 4A110 Francis StreetBoston, MA 02215617/667-515542.33700000000000-71.11000000000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyCharlotte F. and Irving W. Rabb Professor of MedicineFull ProfessorCo-Principal InvestigatorGeneral Clinical Research CenterNIH1977-12-012010-03-31SUKHATME, VIKAS PPrincipal InvestigatorPROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESISNIH1993-07-152003-05-31AFDHAL, NEZAM HASSANCholesterol gallstone disease is one of the commonest digestive diseases in the United States and results in 700,000 cholecystectomies annually with a direct health care cost in excess of $3 billion. Gallbladder mucin plays a central role in gallstone formation and this proposal will examine the mechanism by which mucin interacts with biliary lipids to promote gallstones. The specific Aims are to 1) Characterize the interaction of specific sites of the mucin molecule with lipid vesicles to improve our understanding of how mucin promotes crystallization of cholesterol monohydrate; 2) Characterize how mucin effects the morphology and rate of crystal growth in solution and in gels so that growth inhibitors can eventually be developed; 3) Examine the central role of mucin as the matrix protein in the biomineralization of both calcium and cholesterol. These Aim's will be achieved by utilizing multiple biophysical techniques to examine model systems where mucin and its modified structural forms will interact with biliary lipids similar to those seen in gallstone bile. Fluorescent assays, dynamic light scattering and magic angle spinning magnetic resonance will examine how mucin promotes vesicle fusion and sub- microscopic nucleation. Light and electron microscopy will examine the way in which mucin can promote both the pattern and rate of crystal growth. These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease.Principal InvestigatorAntiviral Therapy in African Americans with HCVNIH2001-08-212006-06-30AFDHAL, NEZAM HASSANThis is a proposal for the Liver Center at BIDMC to act as a clinical trials center in a multicenter collaborative program to examine resistance to antiviral therapy in African Americans with hepatitis C. HCV is a common problem in the US with almost 4 million individuals exposed to the virus. HCV is the commonest cause of cirrhosis and liver cancer in the US. Almost 6% of African Americans have HCV and there response to Interferon based antiviral therapy is only 50% that of non-HIspanic whites. This study will examine the mechanism of viral resistance in African Americans to PEG-Interferon combined with ribavirin and examine the factors potentially responsible for viral resistance. The specific Aims are to 1) Confirm that there is a difference in sustained viral clearance between AA and whites; 2) Identify factors that effect response to antiviral therapy; 3) determine the role of HCV viral kinetics during therapy on subsequent sustained viral clearance; 4) identify virological, immunological-and host genetic factors that determine viral clearance. Approximately 400 patients will be treated with PEG-IFN and ribavirin for 48 weeks and then followed for a further 48 weeks to determine sustained viral eradication. Pretreatment variables will be correlated with viral clearance. Specimens of liver tissue and serum will be collected for basic studies on viral resistance. These studies should help determine the best therapy for AA with HCV.Principal InvestigatorProteomics and Biomarkers for Hepatocellular CancerNIH2003-09-252005-08-31AFDHAL, NEZAM HASSANHepatitis C (HCV) is the commonest cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC) in the United States. HCC occurs primarily in patients with advanced fibrosis and cirrhosis from HCV. Current screening techniques involve the use of serum alfafetoprotein and liver imaging with ultrasound performed in high risk patients on a 3 to 6 monthly basis. Early detection can improve outcomes with liver transplantation and perhaps non-surgical therapies. However screening is not very effective and many patients present with large tumors or multifocal HCC with a median survival of only 6 months. There is a definite clinical need for better non-invasive biomarkers for HCC which can lead to early detection and treatment. The specific aims of this exploratory R21 proposal are to utilize a proteomic approach to identify novel biomarkers for HCC and then evaluate these biomarkers in a cohort of patients with HCV at high risk for HCC. The initial step will be identification of a matching group of patients with a high risk of HCC and those who have developed HCC during the prospective COPILOT study. The COPILOT study provides a large cohort of patients with HCV and cirrhosis who are randomized to treatment with either low dose PEGylated interferon alfa 2b or colchicine and are followed for 4 years with rigorous clinical screening for HCC. The study is in year 2 and the incidence of HCC is approximately 5%. Serum from these patients prior to and after the development of HCC is stored and will be utilized for proteomic studies. Tissue from normal liver and HCC is available from these patients who have undergone liver transplant. A control disease serum bank from patients with HCC unrelated to HCV is also available at BIDMC. The serum and tissue will be examined by proteomics for identification of novel biomarkers using SELDI-TOF mass spectrometry. Careful clinical characterization and matching will assist in the bioinformatic approach necessary to identify candidate biomarkers. Novel proteins and peptide biomarkers will be sequenced and identified and an ELISA will be developed for any promising candidate biomarkers. The candidate biomarker ELISA will then be validated in the large HCV serum bank at BIDMC of patients with all stages of HCV and those in the COPILOT trial. These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials.Co-Principal InvestigatorDeterminants of Liver Injury in Chronic Hepatitis C Virus InfectionNIH/NIAID2005-06-302010-11-28SCHUPPAN, DETLEFThe majority of persons acutely infected with hepatitis C virus (HCV) will develop chronic infection, but not all subjects go on to develop the complications of chronic infection such as hepatic fibrosis or steatosis. Current antiviral treatments are neither effective nor available for most persons with chronic HCV infection, and thus chronic infection remains a significant health problem. The natural history of HCV liver disease combined with the epidemiology of this infection has resulted in an increasing prevalence of persons with chronic HCV, and rising rates of hepatic decomposition and hepatocellular carcinoma. However, our understanding of the host and viral determinants of liver disease progression are poorly understood. This program project will address the determinants of liver injury in chronic HCV infection, using cohorts with rapid disease progression and controls to better understand the factors that distinguish a relatively benign course of HCV from one with progression to cirrhosis. This will be accomplished in three integrated projects: The first Project will test the hypothesis that failure of the CD4 response results in an inappropriate CD8+ cytotoxic T lymphocyte (CTL) and natural killer T (NKT) response that serves to drive fibrosis and viral evolution. The second Project will characterize the role of oxidative stress in chronic HCV and the mechanisms of hepatic steatosis. The third Project will determine which viral and host factors drive hepatic stellate cell activation as a key step in fibrosis. The projects will be supported by a clinical core, which will maintain a repository of clinical samples derived from cohorts with rapid progression (transplant, HIV/HCV co-infection and Schistosoma mansoni co-infection) as well as more slowly progressive disease. This joint use of common clinical material will facilitate maximal integration of results. Through this unique cooperative approach, we will determine which viral and host factors contribute to fibrosis, the major complication of chronic HCV infection, which might suggest new therapeutic strategies to prevent liver disease progression.Principal InvestigatorClinical Center for Phase I/II trials of Silymarin in Chronic Liver DiseaseNIH2006-08-152011-07-31AFDHAL, NEZAM HASSANComplimentary and alternative medicines (CAM) are amongst the most commonly used therapies worldwide and in the US for chronic liver diseases. Silymarin, the active ingredient of the milk thistle, Silybum marianum, is one of the commonest used herbal medications but its efficacy in chronic liver disease is unproven. Liver disease secondary to both hepatitis C (HCV) and non-alcoholic steatohepatitis (NASH) represent 2 of the commonest liver diseases in the US and there is a need for the study of silymarin in these diseases in a controlled clinical trial. We are proposing three collaborative clinical trials to evaluate silymarin versus placebo in HCV patients who have never received treatment, in HCV patients who have failed treatment and in patients with NASH. These will be double blind, placebo controlled phase l/ll trials focusing on dose finding, safety and efficacy of silymarin. The endpoints of the trials will include histological improvement in liver disease and multiple secondary surrogate markers to understand both how silymarin works and to get a preliminary idea of the endpoints to be utilized in larger Phase 3 trials. We also intend to evaluate important secondary factors such as expectations of patients on CAM and effect of silymarin on quality of life. The goal of these studies is to determine whether there is a rationale for larger Phase 3 studies of silymarin in patients with chronic liver disease. http://www.ncbi.nlm.nih.gov/pubmed/39621304Serum protein risk stratification score for diagnostic evaluation of metabolic dysfunction-associated steatohepatitis. Hepatol Commun. 2024 Dec 01; 8(12).Lai M, Dillon ST, Gu X, Morhardt TL, Xu Y, Chan NY, Xiong B, Can H, Ngo LH, Jin L, Zhang X, Moreira CC, Leite NC, Villela-Nogueira CA, Otu HH, Schattenberg JM, Schuppan D, Afdhal NH, Libermann TA. Hepatol Commun2024 Dec 018(12)http://www.ncbi.nlm.nih.gov/pubmed/39244483Deep Learning Based Shear Wave Detection and Segmentation Tool for Use in Point-of-Care for Chronic Liver Disease Assessments. Ultrasound Med Biol. 2024 12; 50(12):1812-1820.Honarvar M, Lobo J, Schneider C, Wolfe N, Gawrieh S, Loomba R, Ramji A, Hassanein T, Yoshida EM, Pang E, Curry MP, Afdhal NH. Ultrasound Med Biol2024 1250(12):1812-1820http://www.ncbi.nlm.nih.gov/pubmed/40416420Methods and Validation of Velacur Determined Fat Fraction in patients with MASLD. WFUMB Ultrasound Open. 2024 Dec; 2(2).Honarvar M, Lobo J, Schneider C, Klein S, Smith GI, Loomba R, Ramji A, Hassanein T, Yoshida EM, Pang E, Curry MP, Afdhal NH. WFUMB Ultrasound Open2024 Dec2(2)http://www.ncbi.nlm.nih.gov/pubmed/38517204Velacur ACE outperforms FibroScan CAP for diagnosis of MASLD. Hepatol Commun. 2024 04 01; 8(4).Loomba R, Ramji A, Hassanein T, Yoshida EM, Pang E, Schneider C, Curry MP, Afdhal NH. Hepatol Commun2024 04 018(4)http://www.ncbi.nlm.nih.gov/pubmed/38274398The Use of Noninvasive Velacur® for Discriminating between Volunteers and Patients with Chronic Liver Disease: A Feasibility Study. Int J Hepatol. 2024; 2024:8877130.Curry MP, Tam E, Schneider C, Abdelgelil N, Hassanien T, Afdhal NH. Int J Hepatol20242024:8877130http://www.ncbi.nlm.nih.gov/pubmed/38134822Case report and mini-review: Sarcina ventriculi in the stomach of an 80-year-old female. Diagn Microbiol Infect Dis. 2024 Feb; 108(2):116137.Kirmaier A, Kubiak J, Mahler L, Qian X, Wu L, Ono Y, Riedel S, Medline A, Yang X, Elamin S, Afdhal N, Arnaout R. Diagn Microbiol Infect Dis2024 Feb108(2):116137http://www.ncbi.nlm.nih.gov/pubmed/36300646A phase 2, open-label, randomized, multiple-dose study evaluating Inarigivir in treatment-naïve patients with chronic hepatitis B. Liver Int. 2023 01; 43(1):77-89.Yuen MF, Chen CY, Liu CJ, Jeng WJ, Elkhashab M, Coffin CS, Kim W, Greenbloom S, Ramji A, Lim YS, Kim YJ, Fung SK, Kim DJ, Jang JW, Lee KS, Iyer RP, Macfarlane C, Jackson K, Locarnini SA, Chan HLY, Afdhal NH. Liver Int2023 0143(1):77-89http://www.ncbi.nlm.nih.gov/pubmed/36750244Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut. 2023 03; 72(3):581-589.Loomba R, Huang DQ, Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, Ding D, Ma L, Jia C, Billin A, Huss RS, Chung C, Goodman Z, Wong VW, Okanoue T, Romero-Gómez M, Abdelmalek MF, Muir A, Afdhal N, Bosch J, Harrison S, Younossi ZM, Myers RP. Gut2023 0372(3):581-589http://www.ncbi.nlm.nih.gov/pubmed/35445803First-line therapies for hepatitis B in the United States: A 3-year prospective and multicenter real-world study after approval of tenofovir alefenamide. Hepatol Commun. 2022 08; 6(8):1881-1894.Pan CQ, Afdhal NH, Ankoma-Sey V, Bae H, Curry MP, Dieterich D, Frazier L, Frick A, Hann HW, Kim WR, Kwo P, Milligan S, Tong MJ, Reddy KR. Hepatol Commun2022 086(8):1881-1894http://www.ncbi.nlm.nih.gov/pubmed/35041626Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2022 03 01; 117(3):453-461.Vieira Barbosa J, Milligan S, Frick A, Broestl J, Younossi Z, Afdhal N, Lai M. Am J Gastroenterol2022 03 01117(3):453-461http://www.ncbi.nlm.nih.gov/pubmed/34662449Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis. Hepatology. 2022 05; 75(5):1235-1246.Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, Abdelmalek MF, Ding D, Han L, Jia C, Huss RS, Chung C, Wong VW, Okanoue T, Romero-Gomez M, Muir AJ, Afdhal NH, Bosch J, Goodman Z, Harrison SA, Younossi ZM, Myers RP. Hepatology2022 0575(5):1235-1246http://www.ncbi.nlm.nih.gov/pubmed/34970870Fibrosis-4 Index as an Independent Predictor of Mortality and Liver-Related Outcomes in NAFLD. Hepatol Commun. 2022 04; 6(4):765-779.Vieira Barbosa J, Milligan S, Frick A, Broestl J, Younossi Z, Afdhal NH, Lai M. Hepatol Commun2022 046(4):765-779http://www.ncbi.nlm.nih.gov/pubmed/34662439Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982.Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. 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Aliment Pharmacol Ther. 2015 Jul; 42(1):106-16.Jiang ZG, Tsugawa Y, Tapper EB, Lai M, Afdhal N, Robson SC, Mukamal KJ. Aliment Pharmacol Ther2015 Jul42(1):106-16http://www.ncbi.nlm.nih.gov/pubmed/25627448Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trials. Hepatology. 2015 Jun; 61(6):1798-808.Younossi ZM, Stepanova M, Marcellin P, Afdhal N, Kowdley KV, Zeuzem S, Hunt SL. Hepatology2015 Jun61(6):1798-808http://www.ncbi.nlm.nih.gov/pubmed/25795586Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir. J Hepatol. 2015 Aug; 63(2):337-45.Younossi ZM, Stepanova M, Afdhal N, Kowdley KV, Zeuzem S, Henry L, Hunt SL, Marcellin P. 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Gastroenterology. 2015 Jan; 148(1):100-107.e1.Curry MP, Forns X, Chung RT, Terrault NA, Brown R, Fenkel JM, Gordon F, O'Leary J, Kuo A, Schiano T, Everson G, Schiff E, Befeler A, Gane E, Saab S, McHutchison JG, Subramanian GM, Symonds WT, Denning J, McNair L, Arterburn S, Svarovskaia E, Moonka D, Afdhal N. Gastroenterology2015 Jan148(1):100-107.e1http://www.ncbi.nlm.nih.gov/pubmed/25109610Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides. Aliment Pharmacol Ther. 2014 Oct; 40(7):804-10.Patwardhan VR, Sengupta N, Bonder A, Lau D, Afdhal NH. Aliment Pharmacol Ther2014 Oct40(7):804-10http://www.ncbi.nlm.nih.gov/pubmed/25002154Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease. Gastroenterol Rep (Oxf). 2014 Nov; 2(4):276-80.Tapper EB, Krajewski K, Lai M, Challies T, Kane R, Afdhal N, Lau D. Gastroenterol Rep (Oxf)2014 Nov2(4):276-80http://www.ncbi.nlm.nih.gov/pubmed/24907384Interferon ?-induced protein 10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: implications for the innate immune response. J Infect Dis. 2014 Dec 15; 210(12):1881-5.Lin JC, Habersetzer F, Rodriguez-Torres M, Afdhal N, Lawitz EJ, Paulson MS, Zhu Y, Subramanian GM, McHutchison JG, Sulkowski M, Wyles DL, Schooley RT. J Infect Dis2014 Dec 15210(12):1881-5http://www.ncbi.nlm.nih.gov/pubmed/24909907FibroScan (vibration-controlled transient elastography): where does it stand in the United States practice. Clin Gastroenterol Hepatol. 2015 Jan; 13(1):27-36.Tapper EB, Castera L, Afdhal NH. Clin Gastroenterol Hepatol2015 Jan13(1):27-36http://www.ncbi.nlm.nih.gov/pubmed/24907500Low likelihood of intracranial hemorrhage in patients with cirrhosis and altered mental status. Clin Gastroenterol Hepatol. 2015 Jan; 13(1):165-9.Donovan LM, Kress WL, Strnad LC, Sarwar A, Patwardhan V, Piatkowski G, Tapper EB, Afdhal NH. Clin Gastroenterol Hepatol2015 Jan13(1):165-9http://www.ncbi.nlm.nih.gov/pubmed/24877870Reply: To PMID 24126097. Gastroenterology. 2014 Jul; 147(1):255-6.Afdhal NH, Theodore D. Gastroenterology2014 Jul147(1):255-6http://www.ncbi.nlm.nih.gov/pubmed/24725238Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014 Apr 17; 370(16):1483-93.Afdhal N, Reddy KR, Nelson DR, Lawitz E, Gordon SC, Schiff E, Nahass R, Ghalib R, Gitlin N, Herring R, Lalezari J, Younes ZH, Pockros PJ, Di Bisceglie AM, Arora S, Subramanian GM, Zhu Y, Dvory-Sobol H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Sulkowski M, Kwo P. N Engl J Med2014 Apr 17370(16):1483-93http://www.ncbi.nlm.nih.gov/pubmed/24725239Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. 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J Viral Hepat2014 Oct21(10):727-33http://www.ncbi.nlm.nih.gov/pubmed/24168254The new paradigm of hepatitis C therapy: integration of oral therapies into best practices. J Viral Hepat. 2013 Nov; 20(11):745-60.Afdhal NH, Zeuzem S, Schooley RT, Thomas DL, Ward JW, Litwin AH, Razavi H, Castera L, Poynard T, Muir A, Mehta SH, Dee L, Graham C, Church DR, Talal AH, Sulkowski MS, Jacobson IM. J Viral Hepat2013 Nov20(11):745-60http://www.ncbi.nlm.nih.gov/pubmed/24126097Eltrombopag increases platelet numbers in thrombocytopenic patients with HCV infection and cirrhosis, allowing for effective antiviral therapy. Gastroenterology. 2014 Feb; 146(2):442-52.e1.Afdhal NH, Dusheiko GM, Giannini EG, Chen PJ, Han KH, Mohsin A, Rodriguez-Torres M, Rugina S, Bakulin I, Lawitz E, Shiffman ML, Tayyab GU, Poordad F, Kamel YM, Brainsky A, Geib J, Vasey SY, Patwardhan R, Campbell FM, Theodore D. 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J Gastroenterol Hepatol. 2011 Apr; 26(4):751-8.Qu KZ, Zhang K, Ma W, Li H, Wang X, Zhang X, Giles F, Lai M, Afdhal NH, Albitar M. J Gastroenterol Hepatol2011 Apr26(4):751-8http://www.ncbi.nlm.nih.gov/pubmed/22557938Chronic hepatitis B: integrating long-term treatment data and strategies to improve outcomes in clinical practice. Gastroenterol Hepatol (N Y). 2011 Mar; 7(3 Suppl 4):1-16.Afdhal NH, Bacon BR, Brown RS. Gastroenterol Hepatol (N Y)2011 Mar7(3 Suppl 4):1-16http://www.ncbi.nlm.nih.gov/pubmed/21254158Quantitation of pretreatment serum interferon-?-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology. 2011 Jan; 53(1):14-22.Darling JM, Aerssens J, Fanning G, McHutchison JG, Goldstein DB, Thompson AJ, Shianna KV, Afdhal NH, Hudson ML, Howell CD, Talloen W, Bollekens J, De Wit M, Scholliers A, Fried MW. Hepatology2011 Jan53(1):14-22http://www.ncbi.nlm.nih.gov/pubmed/21254181Hepatitis C pharmacogenetics: state of the art in 2010. Hepatology. 2011 Jan; 53(1):336-45.Afdhal NH, McHutchison JG, Zeuzem S, Mangia A, Pawlotsky JM, Murray JS, Shianna KV, Tanaka Y, Thomas DL, Booth DR, Goldstein DB. Hepatology2011 Jan53(1):336-45http://www.ncbi.nlm.nih.gov/pubmed/21070775Changes in insulin sensitivity and body weight during and after peginterferon and ribavirin therapy for hepatitis C. Gastroenterology. 2011 Feb; 140(2):469-77.Conjeevaram HS, Wahed AS, Afdhal N, Howell CD, Everhart JE, Hoofnagle JH. Gastroenterology2011 Feb140(2):469-77http://www.ncbi.nlm.nih.gov/pubmed/20979056Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology. 2011 Jan; 53(1):230-42.Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. 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Gastroenterol Clin North Am2010 Jun39(2):185-207, vii-viiihttp://www.ncbi.nlm.nih.gov/pubmed/20478399Health care quality measurement in the care of patients with cirrhosis. Clin Gastroenterol Hepatol. 2010 Aug; 8(8):649-50.Lai M, Afdhal NH. Clin Gastroenterol Hepatol2010 Aug8(8):649-50http://www.ncbi.nlm.nih.gov/pubmed/20399780Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 2010 Jul; 139(1):120-9.e18.Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, Poordad F, Lawitz EJ, McCone J, Shiffman ML, Galler GW, Lee WM, Reindollar R, King JW, Kwo PY, Ghalib RH, Freilich B, Nyberg LM, Zeuzem S, Poynard T, Vock DM, Pieper KS, Patel K, Tillmann HL, Noviello S, Koury K, Pedicone LD, Brass CA, Albrecht JK, Goldstein DB, McHutchison JG. 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Hepatology. 2009 Dec; 50(6):1719-26.Rustgi VK, Lee WM, Lawitz E, Gordon SC, Afdhal N, Poordad F, Bonkovsky HL, Bengtsson L, Chandorkar G, Harding M, McNair L, Aalyson M, Alam J, Kauffman R, Gharakhanian S, McHutchison JG. Hepatology2009 Dec50(6):1719-26http://www.ncbi.nlm.nih.gov/pubmed/19841158Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol. 2010 Apr; 50(4):434-49.Hawke RL, Schrieber SJ, Soule TA, Wen Z, Smith PC, Reddy KR, Wahed AS, Belle SH, Afdhal NH, Navarro VJ, Berman J, Liu QY, Doo E, Fried MW. J Clin Pharmacol2010 Apr50(4):434-49http://www.ncbi.nlm.nih.gov/pubmed/19585653A phase III study of the safety and efficacy of viramidine versus ribavirin in treatment-naïve patients with chronic hepatitis C: ViSER1 results. Hepatology. 2009 Sep; 50(3):717-26.Benhamou Y, Afdhal NH, Nelson DR, Shiffman ML, Halliman DG, Heise J, Chun E, Pockros PJ. Hepatology2009 Sep50(3):717-26http://www.ncbi.nlm.nih.gov/pubmed/19706518Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14321-6.Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Proc Natl Acad Sci U S A2009 Aug 25106(34):14321-6http://www.ncbi.nlm.nih.gov/pubmed/19514117Validation of hepascore, compared with simple indices of fibrosis, in patients with chronic hepatitis C virus infection in United States. Clin Gastroenterol Hepatol. 2009 Jun; 7(6):696-701.Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Clin Gastroenterol Hepatol2009 Jun7(6):696-701http://www.ncbi.nlm.nih.gov/pubmed/19403909Clinical decisions. Management of incidental hepatitis C virus infection. N Engl J Med. 2009 Apr 30; 360(18):1902-6.Afdhal NH, Lok AS, Di Bisceglie AM. 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Gastroenterol Clin Biol2008 Sep32(6 Suppl 1):88-90http://www.ncbi.nlm.nih.gov/pubmed/27948718Utility of four tumor markers, alone and in combination, for detection of hepatocellular carcinoma: AFP, AFP-L3, DCP, and Cystatin. J Clin Oncol. 2008 May 20; 26(15_suppl):4585.Li H, Sferruzza A, Qu KZ, Afdhal NH, Lai M, Radcliff JS, Bender RA. J Clin Oncol2008 May 2026(15_suppl):4585http://www.ncbi.nlm.nih.gov/pubmed/18471546Diagnosis and quantitation of fibrosis. Gastroenterology. 2008 May; 134(6):1670-81.Manning DS, Afdhal NH. Gastroenterology2008 May134(6):1670-81Colchicine Versus Peg-Interferon Alfa 2B long term Therapy: Results of the 4 year copilot trial. Hepatology. 2008; 48:S4.Afdhal NH, Levine R, Brown R Jr.,Freilich B, O'brien M, Brass C. Hepatology200848:S4Identification of Biomakers that measure disease activity in patients with nonalcoholic fatty liver disease. Hepatology. 2008; 48:s355.Malik R, Lai M, BhaskarIN, Curry M, Schuppan D, Afdhal NH. Hepatology200848:s355The Antiviral Response to Tenofovir Disoproxil Fumarate (TDF) Is Comparable in Lamivudine (LAM)-Naive and LAM-Experienced Subjects treated for chronic Hepatitis B (CHB). Gastroenterology. 2008; 134:A809.Afdhal, NH, Manns MP, Lennox JJ, Nguyen T, Berg T, Dalekos GN, Trepo C, Roberts SK, Prieto M, Sorbel J, Anderson J, Mondou E, Rousseau F. Gastroenterology2008134:A809http://www.ncbi.nlm.nih.gov/pubmed/18433919Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008 Jun; 48(6):1000-7.Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, Weksler B, Esteban R. J Hepatol2008 Jun48(6):1000-7http://www.ncbi.nlm.nih.gov/pubmed/18328931Liver cirrhosis. Lancet. 2008 Mar 08; 371(9615):838-51.Schuppan D, Afdhal NH. Lancet2008 Mar 08371(9615):838-51http://www.ncbi.nlm.nih.gov/pubmed/18938661Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis. 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AIDS. 2007 Oct 18; 21(16):2209-16.Sulkowski MS, Mehta SH, Torbenson MS, Higgins Y, Brinkley SC, de Oca RM, Moore RD, Afdhal NH, Thomas DL. AIDS2007 Oct 1821(16):2209-16http://www.ncbi.nlm.nih.gov/pubmed/17894303Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial. Hepatology. 2007 Oct; 46(4):971-81.Jacobson IM, Brown RS, Freilich B, Afdhal N, Kwo PY, Santoro J, Becker S, Wakil AE, Pound D, Godofsky E, Strauss R, Bernstein D, Flamm S, Pauly MP, Mukhopadhyay P, Griffel LH, Brass CA. Hepatology2007 Oct46(4):971-81http://www.ncbi.nlm.nih.gov/pubmed/17916542Stiffness and impedance: the new liver biomarkers. Clin Gastroenterol Hepatol. 2007 Oct; 5(10):1144-6.Malik R, Afdhal N. Clin Gastroenterol Hepatol2007 Oct5(10):1144-6Tolerability of low-dose peginterferon alfa-2B in hepatitis C patients with Cirrhosis: Results from the copilot trial. Hepatology. 2007; 46:825A.Shah MB,Brown RS, Barski T, Freilich B, Levine RA, Afdhal NH . Hepatology200746:825AEltrombopag raises platelet count in 2 weeks in patients with HCv and significant thrombocytopenia. Hepatology. 2007; 46:252A.Afdhal NH, McHutchison JG, Shiffman ML, Rodrigues Torres, M, Dusheioko GM, Sigal S, White S, Blackman N, Cambell F, Dickens T. Hepatology200746:252AComparison of Fibroscan, APRI, AST/ALT and Clinical Signs as non invasive predictors of Cirrhosis. Hepatology. 2007; 46:428A.Malik R, Farnan R, Lai M, Freitag H, Schuppan D, Afdhal NH. Hepatology200746:428AThe Cerebral Metabolic and Cognitive Effects of Pegylated interferon (PIFN) and Hepatitis C Viral (HCV) Clearance. Hepatology. 2007; 46:380A.Byrnes,VM, Miller, A, Hill,E, Weinstein, david Alsop, Lenkinski, R.E, Afdhal, NH, . Hepatology200746:380Ahttp://www.ncbi.nlm.nih.gov/pubmed/17928090The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol. 2007 Dec; 47(6):760-7.Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. J Hepatol2007 Dec47(6):760-7http://www.ncbi.nlm.nih.gov/pubmed/17654603Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology. 2007 Aug; 46(2):324-9.Pockros PJ, Schiff ER, Shiffman ML, McHutchison JG, Gish RG, Afdhal NH, Makhviladze M, Huyghe M, Hecht D, Oltersdorf T, Shapiro DA. Hepatology2007 Aug46(2):324-9Noninvasive markers of Liver fibrosis. Advances in Digestive Diseases. Editor: Howden CW. 2007; 121 - 134.Lai M, Afdhal NH. Advances in Digestive Diseases. Editor: Howden CW2007121 - 134http://www.ncbi.nlm.nih.gov/pubmed/17521396The clinical outcome of small (<20 mm) arterially enhancing nodules on MRI in the cirrhotic liver. Am J Gastroenterol. 2007 Aug; 102(8):1654-9.Byrnes V, Shi H, Kiryu S, Rofsky NM, Afdhal NH. Am J Gastroenterol2007 Aug102(8):1654-9http://www.ncbi.nlm.nih.gov/pubmed/17402780Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. Biomacromolecules. 2007 May; 8(5):1580-6.Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S. Biomacromolecules2007 May8(5):1580-6http://www.ncbi.nlm.nih.gov/pubmed/17393526Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysis. Hepatology. 2007 Apr; 45(4):886-94.Goodman ZD, Becker RL, Pockros PJ, Afdhal NH. Hepatology2007 Apr45(4):886-94Nonivasive diagnosis of NASH. Nonalcoholic steatohepatitis (NASH) Editors: Bataller R, Caballeria J. 2007; 111-120.Becker L, Afdhal NH. Nonalcoholic steatohepatitis (NASH) Editors: Bataller R, Caballeria J2007111-120http://www.ncbi.nlm.nih.gov/pubmed/17326152Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis. Hepatology. 2007 Mar; 45(3):569-78.Pockros PJ, Jeffers L, Afdhal N, Goodman ZD, Nelson D, Gish RG, Reddy KR, Reindollar R, Rodriguez-Torres M, Sullivan S, Blatt LM, Faris-Young S. Hepatology2007 Mar45(3):569-78http://www.ncbi.nlm.nih.gov/pubmed/17308970The not so good effects of nitric oxide inhibition with methylene blue in cirrhosis and ascites. Dig Dis Sci. 2007 Apr; 52(4):939-40.Cárdenas A, Curry M, Afdhal NH. Dig Dis Sci2007 Apr52(4):939-40http://www.ncbi.nlm.nih.gov/pubmed/17316879Technology evaluation: a critical step in the clinical utilization of novel diagnostic tests for liver fibrosis. J Hepatol. 2007 Apr; 46(4):543-5.Afdhal NH, Curry M. J Hepatol2007 Apr46(4):543-5http://www.ncbi.nlm.nih.gov/pubmed/17316875Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C. J Hepatol. 2007 Apr; 46(4):620-7.Esmat G, Metwally M, Zalata KR, Gadalla S, Abdel-Hamid M, Abouzied A, Shaheen AA, El-Raziky M, Khatab H, El-Kafrawy S, Mikhail N, Magder LS, Afdhal NH, Strickland GT. J Hepatol2007 Apr46(4):620-7http://www.ncbi.nlm.nih.gov/pubmed/17187406Race, insulin resistance and hepatic steatosis in chronic hepatitis C. Hepatology. 2007 Jan; 45(1):80-7.Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH, Wahed AS. Hepatology2007 Jan45(1):80-7http://www.ncbi.nlm.nih.gov/pubmed/17006909Modeling hepatic fibrosis in African American and Caucasian American patients with chronic hepatitis C virus infection. Hepatology. 2006 Oct; 44(4):925-35.Fontana RJ, Kleiner DE, Bilonick R, Terrault N, Afdhal N, Belle SH, Jeffers LJ, Ramcharran D, Ghany MG, Hoofnagle JH. Hepatology2006 Oct44(4):925-35http://www.ncbi.nlm.nih.gov/pubmed/16979947Fibrosis as an end point for clinical trials in liver disease: a report of the international fibrosis group. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1214-1220.McHutchison J, Poynard T, Afdhal N. Clin Gastroenterol Hepatol2006 Oct4(10):1214-1220http://www.ncbi.nlm.nih.gov/pubmed/16890601Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology. 2006 Aug; 131(2):470-7.Conjeevaram HS, Fried MW, Jeffers LJ, Terrault NA, Wiley-Lucas TE, Afdhal N, Brown RS, Belle SH, Hoofnagle JH, Kleiner DE, Howell CD. Gastroenterology2006 Aug131(2):470-7http://www.ncbi.nlm.nih.gov/pubmed/16831603Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Gastroenterology. 2006 Jul; 131(1):210-22.Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Gastroenterology2006 Jul131(1):210-22http://www.ncbi.nlm.nih.gov/pubmed/16762645Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology. 2006 Jun; 130(7):2229-34.Mueller S, Afdhal NH, Schuppan D. Gastroenterology2006 Jun130(7):2229-34http://www.ncbi.nlm.nih.gov/pubmed/28316514Noninvasive Markers of Liver Fibrosis. Gastroenterol Hepatol (N Y). 2006 Jun; 2(6):413-415.Afdhal NH. Gastroenterol Hepatol (N Y)2006 Jun2(6):413-415http://www.ncbi.nlm.nih.gov/pubmed/16628640Duration of peginterferon therapy in acute hepatitis C: a randomized trial. Hepatology. 2006 May; 43(5):923-31.Kamal SM, Moustafa KN, Chen J, Fehr J, Abdel Moneim A, Khalifa KE, El Gohary LA, Ramy AH, Madwar MA, Rasenack J, Afdhal NH. Hepatology2006 May43(5):923-31http://www.ncbi.nlm.nih.gov/pubmed/16557547Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology. 2006 Apr; 43(4):771-9.Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, Al Tawil A, Nooman A, Massoud M, Koziel MJ, Afdhal NH. Hepatology2006 Apr43(4):771-9http://www.ncbi.nlm.nih.gov/pubmed/16557548Progression of liver fibrosis among injection drug users with chronic hepatitis C. Hepatology. 2006 Apr; 43(4):788-95.Wilson LE, Torbenson M, Astemborski J, Faruki H, Spoler C, Rai R, Mehta S, Kirk GD, Nelson K, Afdhal N, Thomas DL. Hepatology2006 Apr43(4):788-95http://www.ncbi.nlm.nih.gov/pubmed/16527651Antiviral therapy for treatment naïve patients with hepatitis C virus. Infect Dis Clin North Am. 2006 Mar; 20(1):99-113, vi-vii.Oh S, Afdhal NH. Infect Dis Clin North Am2006 Mar20(1):99-113, vi-viihttp://www.ncbi.nlm.nih.gov/pubmed/16530503Peginterferon alfa-2b therapy in acute hepatitis C: impact of onset of therapy on sustained virologic response. Gastroenterology. 2006 Mar; 130(3):632-8.Kamal SM, Fouly AE, Kamel RR, Hockenjos B, Al Tawil A, Khalifa KE, He Q, Koziel MJ, El Naggar KM, Rasenack J, Afdhal NH. Gastroenterology2006 Mar130(3):632-8http://www.ncbi.nlm.nih.gov/pubmed/16531969Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis. Ann Hepatol. 2006 Jan-Mar; 5(1):56-9.Byrnes V, Afdhal N, Challies T, Greenstein PE. Ann Hepatol2006 Jan-Mar5(1):56-9Future therapies for hepatitis C. Current Hepatitis Reports. 2006; 5:121-128.Khokar AS, Byrnes V, Afdhal NH . Current Hepatitis Reports20065:121-128http://www.ncbi.nlm.nih.gov/pubmed/16380638Overexpression of estrogen receptor alpha increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice. J Lipid Res. 2006 Apr; 47(4):778-86.Wang HH, Afdhal NH, Wang DQ. J Lipid Res2006 Apr47(4):778-86http://www.ncbi.nlm.nih.gov/pubmed/16352364Assessment of liver fibrosis in co-infected patients. J Hepatol. 2006; 44(1 Suppl):S126-31.Kelleher TB, Afdhal N. J Hepatol200644(1 Suppl):S126-31Role of liver Biopsy in Patients with Normal ALT and High HBV DNA. Hepatology. 2005; 42(4):188A.Michelle Lai, Benjamin Hyatt, BIDMC, Boston, MA; Nezam Afdhal, BIDMC, Boston, MA. Hepatology200542(4):188APeginterferon Alfa-2A and ribavirin in African american and caucasian patients with chronic hepatitis C, Genotype 1. hepatology. 2005; 42(4):90A.Hari S. Conjeevaram, University of Michigan, Ann Arbor, MI; Michael W. Fried, University of North Carolina, Chapel Hill, NC; Lennox J. Jeffers, VA Medical Center, Miami, FL; Norah Terrault, UCSF, San Francisco, CA; Thelma E. Wiley-Lucas, Rush University Medical Center, Chicago, IL; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Robert S. Brown Jr, New York Presbyterian-Columbia Presbyterian Center, New York, NY; Steve H. Belle, University of Pittsberg, Pittsburgh, PA; Patricia R. Robuck, NIDDK, NIH, Bethesda, MD; Charles D. Howell, University of Maryland, Baltimore, MD. hepatology200542(4):90ARandomized trial of valopicitabine (NM283), alone or with Peg-Interferon, VS. Retreatment with peg-interferon plus ribavirin (Peginf/rbv) in hepatitis C patients with pervious non-response to pegifn/rbv: first interi, results. Hepatology. 2005; vol. 42(no. 4):69A.Christopher O'brien, University of Miami, Miami, FL; Eliot Godofsky, Bach & Godofsky, Brandenton, FL; Maribel Rodriguez-Torres, Fundacion de Investigacion de diego, Sanurce, Puerto Rico; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; S.C. Pappas, St. Luke's Episcopal Hospital. Hepatology2005vol. 42(no. 4):69AMice overexpressing 11B-hydroxysteriod-dehydrogenase (HSD-1) in adipose tisure develop NASH and progressive pericentral fibrosis on a high fat diet. Hepatology. 2005; 42(4):168A.Yury Popov, BIDMC, Harvard Medical School, Boston, MA; Sebastian Meuller, Brad Turner, BIDMC, Harvard Medical School, Boston, MA; N. Zinkin, BIDMC, Boston, MA; I. Nasser, H. Masuzaki, BIDMC, Harvard Medical School, Boston, MA; J. Vriereck, Dept. or Neurology and Biophysics, Boston Medical Center, Boston, MA; J. Hamilton, Dept. or Neurology and Biophysics Boston Medical Center, Boston, MA; J. Flier, Nezam Afdhal, Detlef Schuppan, BIDMC, Harvard Medical School, Boston, MA. Hepatology200542(4):168ARelationship of HCV RNA responses to CPG 10101, A TLR9 Agonist: Pharmacodynamics and patient characteristics. Hepatology. 2005; 42(4):75A.John McHutchinson, Duke Univeristy, Durham, NC; Bruce Bacon, St. Louis University Hospital, St. Louis, MO; Stuart C. Gordon, Henry Ford Hospital, Detroit, MI; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Michell Shiffman, Medical College of Virginia, Richmond, VA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira Jacobson, Cornell University, New York, NY; Andrew Muir, Duke Univeristy, Duram, NC; Susan Elfer, Coley Pharmaceutical Group, Ottawa, Canada; Mohammed Al-Adhami, Coley Pharmaceuticals Group, Wellesley, MA; Heather Davis, Coley Pharmaceutical Group, Ottawa, Canada; Tess Schmalbach, Coley Pharmaceutical Group, Wellesley, MA. Hepatology200542(4):75ARandomized Placebo-Controlled trial of Tolvaptan, a novel v2-receptor antagonist, in hyponatremia: results of the salt 2 trial with emphasis on efficacy and safety in cirrohosis. hepatology. 2005; 42(4):172A.Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Andres Cardenas, BIDMC, Boston, MA; Monica Guevara Univ Barcelona, Barcelona, Spain; Peter Gross Unvi Car; Gustav Carus Dresden, Dresden, Germany; Joseph varbalis, Georgetown Univ Medical center, Washington, DC; Thomas Berl; Robert Schrier, Univ of Colorado health Science Center, Denver, CO; Daniel Bichet Hospital de sacre Courer de Montreal, Montreal Canada; Lynn Wagoner, Univ of Cinncinnati Heart and Vascular Center. Cincinnati, OH; John Ouyang; Cesare Orlandi; Frank Czerwiec, Otsuka Maryland Research Institute, Rockville, MD. hepatology200542(4):172AA Combined Proteomic and Serologic approach to Diagnosis of Hepatocellular Carcinoma. Hepatology. 2005; vol. 42(no. 4):72A.Noah T. Zinkin, Beth Israel Deaconess Medical Center, Boston, MA; Hasan H. Otu, Dimitrios Spentzos, Manuel Aivado, Meghan Wells, Beth Israel Deaconess Medical Center, proteomics Core, Boston, MA; Brett D. Kalmowitz, K.R. Bhaskar, Beth Israel Deaconess Medical Center, Boston, MA; Towia A. Libermann, Beth Israel Deaconess Medical Center, Proteomics Core, Boston, MA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA. Hepatology2005vol. 42(no. 4):72AAsence of effect of Pegylated interferon Alfa-2B on the pharmacokenetics of valopicitabine (NM283) in patients with chronic hepatitis C. Hepatology. 2005; 42(4):148A.Xiao-Jian Zhou, Idenix Pharmaceuticals, Inc., Cambridge, MA; Maribel Rodiguez-Torres, Funacion de Investigacion de Diego, Santurce; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Eliot Godofsky, Bach & Godofsky, Bradenton, FL; Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Barbara Fielman Constance, George Chao, Steven Knox, Nathaniel A. Brown, Idenix Pharmaceuticals, Cambridge, MA. Hepatology200542(4):148AWeight-based ribavirin dosing (WBD) increases sustained viral response (SVR) in patients with chronic hepatitis C (CHC): Final results of the WIN-R study, A US community based trial. Hepatology. 2005; 42(4):77A.Ira M. Jacobson, Weill Medical College of Cornell University, new York, NY; Robert S. Brown, Columbia University College of Physicians & Surgeons, New York, NY; Bradley Freilich, Baptist Medical Center, Kansas City, MO; Nezam Afdhal, beth Israel Deaconess Medical Center, Boston, MA; Pauk Kwo, Indian University School of Medicine, Indianapolis, IN; John Santoro, Atlantic Gastroenterology Associates, Egg Harbor Township, NJ; Scott becker, Austin Gastroenterology, PA, Austin, TX; Adil Wakil, California Pacific Medical Center, San Francisco, CA; David Pound, Indianapolis Gastroenterology Rsch, Indianapolis, IN; Eliot Godofsky, Bach and Godofsky, MD PA, Bradenton, FL; Robert Strauss, Northwest Georgia Gastroenterology Associates, P.C. Marietta, GA; David Bernstein, North Shore University Hospital, Mahasset, NY; Steven Flamm, Northwestern Memorial Hospital, Chicago, IL; Natrajan Bala, Gastroenterology consultants, Houston, TX; Victor Araya, Albert Einstein Medical Center, Philadelphia, PA; Mitchell Davis, SOuth Florida center of Gastroenterology, P.A., Wellington, FL; Howard Monsour, Liver Specialists of Texas, Houston, TX; John Vierling, Cedars-Sinai Medical Center, Los Angeles, CA; Fredric Regenstein, Tulane University Medical School, New Orleans, LA; Vijay Balan, Mayo Clinic, Phoenix, AZ; Michael Dragutsky, GI Consultants of the Midshouth, Memphis; TN; Michael Epstein, Digestive Disorders Associates Annapolis, MD; Robert W. Herring, Nashville, TN; Raymond Rubin, Atlanta Gastroenterology Assoc, Atlanta, GA; Greg Galler, Kelsey-Seubold Clinic, Houston, TX; Mary Pat Pauly, Kaiser Permanente, Sacramento, CA; Louis H. Griffel; Clifford A. Brass, Schering-Plough Research Institute, kenilworth, NJ; the WIN-R S. Group, kenilworth, NJ. Hepatology200542(4):77AImmunophenotyping profile of CPG 10101, a new TLR9 agonist antiviral for hepatitis C. Hepatology. 2005; 42(4):148A.John G. McHutchinson, Duke Univ, Durham, NC; Bruce R. Bacon, St. Louis Univ Hopsital, St. Louis, MO; Stuart C. Gordon, Henry Ford Hospital, Detroit, MI; Eric Lawitz, Alamo Medical Research, San Antonio, TX; Mitchell Shiffman, Medical College of Richmond Virginia, Richmond, VA; Nezam H. Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira M. Jacobson, Cornell Univ, New York, NY; Andrew Muir Duke University, Durham, NC; Susan M. Efler, A. Vicari, K. Myette, Nav Ahluwalia, P.P. Murzenok Coley Pharmalbach, Art M. Krieg, Coley Pharmaceutical Group, Ottawa, Canada. Hepatology200542(4):148ALiver Stiffness and biomarkers: Correlation with cirrhosis, protal hypertension and hepatic synthetic function. hepatology. 2005; 42(4):112A.Asim Khokhar, Rory farnan, Chelsea MacFarlane, BIDMC, Boston, MA; Bruce Bacon, SLU, St. Louis, MO; John McHutchison, Duke Univ medical center, Durham, NC; Nezam Afdhal, beth Israel Deaconess medical Center, Boston, MA. hepatology200542(4):112ADouble-Dose PegInterferon Alfa-2B with wieghtbased ribavirin improves response for interferon/ribavirin non-responders with hepatitis C: Final results of "RENEW". Hepatology. 2005; vol. 42(No. 4):63A.John Gross, Stephanie Johnson, Mayo Clinic, Rochester, MN; Paul Kwo, Indiana U. School of Medicine, Indianapolis, IN; Nezam H. Afdhal, beth Israel Deaconess Medical Center, Boston, MA; Stven Flamm, Northwestern U. Department of Medicine, Chicago, IL; Terry Therneau, The RENEW Investigators, Mayo Clinic, Rochester, MN. Hepatology2005vol. 42(No. 4):63Ahttp://www.ncbi.nlm.nih.gov/pubmed/16283779Atomic force microscopy reveals aggregation of gastric mucin at low pH. Biomacromolecules. 2005 Nov-Dec; 6(6):3458-66.Hong Z, Chasan B, Bansil R, Turner BS, Bhaskar KR, Afdhal NH. Biomacromolecules2005 Nov-Dec6(6):3458-66http://www.ncbi.nlm.nih.gov/pubmed/16207570Noninvasive assessment of liver fibrosis. Clin Liver Dis. 2005 Nov; 9(4):667-83, vii.Kelleher TB, Afdhal N. Clin Liver Dis2005 Nov9(4):667-83, viihttp://www.ncbi.nlm.nih.gov/pubmed/16023976Use of growth factors with antiviral therapy for chronic hepatitis C. Clin Liver Dis. 2005 Aug; 9(3):439-51, vii.Curry MP, Afdhal NH. Clin Liver Dis2005 Aug9(3):439-51, viiSafety, Pharmacodynamic (PD) and Pharmacokinetic (PK) profiles of CPG 10101 (Actilon-TM), a novel TLR9 Agonist: Comparison in Normal Volenteers and HCV infected Individuals. Gastroenterology. 2005; 128(4):p-91.Bruce R. Bacon, John G. McHutchison, Stuart C. Gordon, Nezam H. Afdhal, Ira M. Jacobson, Mitchell Schiffman, Andrew Muir, Arthur M. Krieg, Susan Elfer, Mary Lou Morris, John Whisnant, Mohammed Al-Adhami, Heather Davis, Tess Schmalbach. Gastroenterology2005128(4):p-91Valopitabine (nm283) alone and in combination with peg-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study. Gastroenterology. 2005; 128(4):p-90.Maribel Rodiguez-Torres, Eric Lawitz, Eliot Godofsky, Nezam Afdhal, George Chao, Barbara Fielman Constance, Steven Knox, Nathaniel A. Brown. Gastroenterology2005128(4):p-90Impaired Gallbladder motility and accelerated cholesterol crystallization and Gallstone formation in mice overexpressing human mucin gene 1 (hmuc1). Gastroenterology. 2005; 128(4):p-103.Helen H. Wang, Nezam H. Afdhal, David Q. Wang. Gastroenterology2005128(4):p-103Long term cohort study of the clinical and histologicalprogression of HCV. Gastroenterology. 2005; 128(4):p-195.Sanaa Kamal, Ahmed Al Tawil, Qi HE, Khalifa Sayed, Kheiry El Naggar, Sarah Hakam, Wafaa Saleh, Manal El Sayed, Leonardo Bianchi, Mohamed Madwar, Nezam Afdhal. Gastroenterology2005128(4):p-195Combined Serological and clinical measures enhance the non-invasive diagnosis of advanced fibrosis in NAFLD. Gastroenterology. 2005; 128(4):p-227.Stephen A. Harrison, Chris Fincke, Sangik Oh, Thomas Kelleher, Katie Smith, Nezam Afdhal. Gastroenterology2005128(4):p-227Pharmacokinetics and Pharmacodynamics of Valopictabine (nm283), a new nucleoside Hcv polymerase inhibitor: results from a phase I/ii dose-escalation trial in patients with Hcv-1 infection. Gastroenterology. 2005; 128(4):a-700.Xiao-Jian Zhou, Nezam Afdhal, Eliot Godofsky, Jules Dienstag; Vinod Rustgi, Lawton Schick. Lael Duncan, Barbara Fielman Constance, George Chao, Nathaniel A. Brown. Gastroenterology2005128(4):a-700Final Result of a double-blind, Placebo-controlled trial of the antibibrotic efficacy of INF Gamma-1b in chronic hepatitis C patients with advanced fibrosis or cirrosis. Gastroenterology. 2005; 128(4):p-175.Paul J. Pockros, Lennox Jeffers, Nezam Afdhal, Zachary D. Goodman, David Nelson, Robert Gish, Rajender Reddy, Robert Reindollar, Maribel Rodiguez-Torres, Sima FarisYoung, Sara Sullivan, Lawrence M. Blatt. Gastroenterology2005128(4):p-175Cerebral Metabolic and neuropsychiatric effects of pegylated interferon (PIFN) therapy in Hepatitis C. Gastroenterology. 2005; 128(4):p-22.Valerie Byrnes, Anne Miller, Cheryl Weinstein, Erin Hill, Robert Lenkinski, David Alsop, Nezam H. Afdhal. Gastroenterology2005128(4):p-22proteomic Profiling of Hepatocellular carcinoma with Seldi-Tof Mass Spectrometry in Patients with Chronic Liver Disease. Gastroenterology. 2005; 128(4):a-30.Noah T. Zinkin, Hassan H. Otu, Dimitrios Spentzos, Manuel Aivado, meghan Wells, Towia A. Liberman, Nezam H. Afdhal. Gastroenterology2005128(4):a-30http://www.ncbi.nlm.nih.gov/pubmed/15877349Viscoelastic properties and dynamics of porcine gastric mucin. Biomacromolecules. 2005 May-Jun; 6(3):1329-33.Celli J, Gregor B, Turner B, Afdhal NH, Bansil R, Erramilli S. Biomacromolecules2005 May-Jun6(3):1329-33http://www.ncbi.nlm.nih.gov/pubmed/15894397Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: the SHASTA index. J Hepatol. 2005 Jul; 43(1):78-84.Kelleher TB, Mehta SH, Bhaskar R, Sulkowski M, Astemborski J, Thomas DL, Moore RE, Afdhal NH. J Hepatol2005 Jul43(1):78-84http://www.ncbi.nlm.nih.gov/pubmed/15975544Two-year results of a randomised double-blinded trial evaluating silymarin for chronic hepatitis C. Dig Liver Dis. 2005 Jul; 37(7):542-3.Strickland GT, Tanamly MD, Tadros F, Labeeb S, Makld H, Nessim D, Mikhail N, Magder LS, Afdhal NH, Medhat A, Abdel-Hamid M. Dig Liver Dis2005 Jul37(7):542-3Effect of Maintenance PEG-Intron Therapy on Portal Hypertension and its Complications: Results from the CoPilot Study. Journal of Hepatology. 2005; 42(4):40.M. Curry, A. Cardenas, N.H. Afdhal. Liver Center, Beth Israel Deaconess Medical Center, Boston, MA, USA. Journal of Hepatology200542(4):40Enhanced Antiviral Efficacy For Valopicitabine (NM283) Plus Peg-Interferon in Hepatitis C Patients With HCV Genotype-1 Infection: Results of a Phase IIa Multicenter Trial. Journal of Hepatology. 2005; 42(2):39-40.N. Afdhal, M Rodriguez-Torres, E. Lawitz, E. Godofsky, G. Chao, B. Fielman, S Knox, M. Brown, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Fundacion de Investigacion de Diego, Santurce, PR, USA; Alamo medical Research, San Antonio, TX, USA; Bach & Godofsky, Bradenton, FL, USA; Idenix Pharmaceuticals, Cambridge, MA, USA. Journal of Hepatology200542(2):39-40Pharmacokinetics and Pharmacodynamics of Valopicitabine(NM283), A New Nucleoside HCV Polymerase Inhibitor: Results from a phase I/II Dose-Escalation Trial in Patients with HCV-1 Infection. Journal of Hepatology. 2005; 42(4):229.X.J. Zhou, N. Afdhal, E Godofsky, J. Dienstag, V. Rustgi, L. Schick, D. McInery, B.A. Fielman, N.A. Brown. Idenix Pharmaceuticals, Inc, Cambridge, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA; Bach & Godofsky, Bradenton, FL, USA; Massachusetts general Hospital, Boston, MA, USA; Metropolitan Research, Fairfax, VA, USA; University of Massachusetts Health Center, Worcester, MA, USA; Northwest Medical Specialties, Tacoma, WA, USA. Journal of Hepatology200542(4):229The Fate of Arterial Enhancing Nodules on MRI in the Cirrhotic Liver. Journal of Hepatology. 2005; 42(4):90-91.V.M. Byrnes, H. Shi, S. Kiryu, N.M. Rofsky, N.H. Afdhal. Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Deparment of Radiology, Beth Israel Deaconess medical Center, Boston, MA, USA. Journal of Hepatology200542(4):90-91http://www.ncbi.nlm.nih.gov/pubmed/15822034Management of hepatitis C virus in special populations: patient and treatment considerations. Clin Gastroenterol Hepatol. 2005 Apr; 3(4):311-8.Gish RG, Afdhal NH, Dieterich DT, Reddy KR. Clin Gastroenterol Hepatol2005 Apr3(4):311-8http://www.ncbi.nlm.nih.gov/pubmed/15753527An unusual cause of abdominal pain in a patient with hepatitis C cirrhosis. Gut. 2005 Apr; 54(4):460, 521.Cárdenas A, Afdhal NH, Khwaja K. Gut2005 Apr54(4):460, 521http://www.ncbi.nlm.nih.gov/pubmed/15802977Hepatic steatosis and antiretroviral drug use among adults coinfected with HIV and hepatitis C virus. AIDS. 2005 Mar 24; 19(6):585-92.Sulkowski MS, Mehta SH, Torbenson M, Afdhal NH, Mirel L, Moore RD, Thomas DL. AIDS2005 Mar 2419(6):585-92http://www.ncbi.nlm.nih.gov/pubmed/16265151Can serum markers be used to reliably detect liver fibrosis? Nat Clin Pract Gastroenterol Hepatol. 2005 Mar; 2(3):132-3.Afdhal N. Nat Clin Pract Gastroenterol Hepatol2005 Mar2(3):132-3http://www.ncbi.nlm.nih.gov/pubmed/15701299Maintenance therapy for chronic hepatitis C. Curr Gastroenterol Rep. 2005 Feb; 7(1):50-3.Kelleher TB, Afdhal N. Curr Gastroenterol Rep2005 Feb7(1):50-3http://www.ncbi.nlm.nih.gov/pubmed/15565613Epoetin alfa improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology. 2004 Dec; 40(6):1450-8.Pockros PJ, Shiffman ML, Schiff ER, Sulkowski MS, Younossi Z, Dieterich DT, Wright TL, Mody SH, Tang KL, Goon BL, Bowers PJ, Leitz G, Afdhal NH. Hepatology2004 Dec40(6):1450-8http://www.ncbi.nlm.nih.gov/pubmed/15571006Randomised double-blinded trial evaluating silymarin for chronic hepatitis C in an Egyptian village: study description and 12-month results. Dig Liver Dis. 2004 Nov; 36(11):752-9.Tanamly MD, Tadros F, Labeeb S, Makld H, Shehata M, Mikhail N, Abdel-Hamid M, Shehata M, Abu-Baki L, Medhat A, Magder LS, Afdhal NH, Strickland GT. Dig Liver Dis2004 Nov36(11):752-9Colchicine versus PEG- Intron long term (CoPilot) trial: Interim analysis of clinical outcomes at year 2. Hepatology. 2004; 40(4):239A.Nezham Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Bradley Freilich, Kansas Digetsive Diseases, Kanas City, MO; Robert Levine, Syracuse Univeristy, Syracuse, NY; Maritin Black, Temple University, Philadelphia, PA; Robert Brown Jr, Columbia College of Physicians and Surgeons, New York, NY; Howard Monsour, GI and Liver Associates, Granbury, TX; Michael O'Brien, Boston Medical Center, Boston, MA; Clifford Brass, Schering Plough, Kenilworth, NJ. Hepatology200440(4):239AThe Epidemiology and survival of patients with Hepatocellular Carcinoma in the United States - A prelininary report from the liver cancer network. Hepatology. 2004; 40(4):216A.Alex S Befer, Saint Louis University, St Louis, MO; Jorge A Marrero, Univeristy of Michigan, Ann Arbor, MI; Ravi S Chari, Vanderbilt Univeristy, Nashville, TN; Lewis Roberts, Mayo Clinic, Rochester, MN; Nezam Afdhal, Harvard University Beth Israel Deaconess Hopsital, Boston, MA; David van Thiel, Loyola Univeristy, Chicago, IL; Adrian M Di Bisceglie, Saint Louis Univeristy, St Louis, MO. Hepatology200440(4):216AFinal phase I/II trial results for NM283, A new polymerase inhibitor for Hepatitis C: Antiviral efficancy and tolerance in patients with HCV-1 infection, including previous interferon failures. Hepatology. 2004; 40(4):726A.Nezam Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Eliot Godofsky, Bach & Godofsky, Brandenton, FL; Jules Dienstag, Massachusetts general Hospital, Boston MA; Vinod Rustgi, Metropolitan Research, Fairfax, VA; Lawton Schick, University of Massachusetts Health Center, Worcester, MA; David McEniry, Northwest Medical Specialties, PLLC, Tacoma, WA; Xiao-Jian Zhou, George Chao, Christopher Fang, Barbara Fielman, Maureen Myers, Nathaniel Brown, Idenix Pharmaceuticals, Cambridge, MA. Hepatology200440(4):726AHuman pharmacological activity of a new TLR9 agonist antiviral, CPG 10101 (Actilon). Hepatology The official Journal of the American Association for the Study of Liver Disease. 2004; 40(4):697A.John G McHutchison, Duke University, Durham, NC; Bruce R Bacon, Saint Louis University School of Medicine, Saint Louis MO; Stuart C Gordon, William Beaumont Hospital, Royal Oak, MI; Nezam H Afdhal, Beth Israel Deaconess Medical Center, Boston, MA; Ira M Jacobson, Cornell University, New York, NY; Andrew Muir, Duke Univeristy, Durham, NC; Arthur M Krieg, Susan Efler, Mohammed Al-Adhami, Heather L Davis, Tess K Schmalback, Coley Pharmaceutical Group, Inc. Wellesley, MA. Hepatology The official Journal of the American Association for the Study of Liver Disease200440(4):697Ahttp://www.ncbi.nlm.nih.gov/pubmed/15324940Antiviral therapy for treatment naïve patients with hepatitis C virus. Gastroenterol Clin North Am. 2004 Sep; 33(3):497-511, viii.Oh S, Afdhal NH. Gastroenterol Clin North Am2004 Sep33(3):497-511, viiihttp://www.ncbi.nlm.nih.gov/pubmed/15265953Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol. 2004 Aug 01; 173(3):2159-66.Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdhal N, Koziel MJ, Exley MA. J Immunol2004 Aug 01173(3):2159-66http://www.ncbi.nlm.nih.gov/pubmed/15277345Biopsy or biomarkers: is there a gold standard for diagnosis of liver fibrosis? Clin Chem. 2004 Aug; 50(8):1299-300.Afdhal NH. Clin Chem2004 Aug50(8):1299-300http://www.ncbi.nlm.nih.gov/pubmed/15236189Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones. Gastroenterology. 2004 Jul; 127(1):239-49.Wang HH, Afdhal NH, Wang DQ. Gastroenterology2004 Jul127(1):239-49http://www.ncbi.nlm.nih.gov/pubmed/15239095Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV. Hepatology. 2004 Jul; 40(1):125-32.Graham CS, Curry M, He Q, Afdhal N, Nunes D, Fleming C, Horsburgh R, Craven D, Sherman KE, Koziel MJ. Hepatology2004 Jul40(1):125-32http://www.ncbi.nlm.nih.gov/pubmed/15180741Evaluation of liver fibrosis: a concise review. Am J Gastroenterol. 2004 Jun; 99(6):1160-74.Afdhal NH, Nunes D. Am J Gastroenterol2004 Jun99(6):1160-74http://www.ncbi.nlm.nih.gov/pubmed/15131791Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroenterology. 2004 May; 126(5):1302-11.Afdhal NH, Dieterich DT, Pockros PJ, Schiff ER, Shiffman ML, Sulkowski MS, Wright T, Younossi Z, Goon BL, Tang KL, Bowers PJ. Gastroenterology2004 May126(5):1302-11http://www.ncbi.nlm.nih.gov/pubmed/15075252Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G547-54.Wang HH, Afdhal NH, Gendler SJ, Wang DQ. Am J Physiol Gastrointest Liver Physiol2004 Sep287(3):G547-54http://www.ncbi.nlm.nih.gov/pubmed/15191694Genetic analysis of cholesterol gallstone formation: searching for Lith (gallstone) genes. Curr Gastroenterol Rep. 2004 Apr; 6(2):140-50.Wang DQ, Afdhal NH. Curr Gastroenterol Rep2004 Apr6(2):140-50Oral IDN-6556, An Anti-Apoptotic Caspase Inhibitor, Lowers Aminotransferases in HCV Patients. Gastroenterology. 2004; 126(4):A-668.Eugene R Schiff, Paul Pockros, Mitchell L Shiffman, John McHutchison, Robert Gish, Nezam H Afdhal, Manana Makhviladze, Mira Huyghe, David Hecht, Tilman Oltersdorf, David A. Shapiro. Gastroenterology2004126(4):A-668Long-term Treatment with Epoetin Alfa Maintains Ribavirin Dose and Hemoglobin Levels in Anemic HCV-Infected Patients Receiving Interferon/Ribavirin (IFN/RBV)Therapy. Gastroenterology. 2004; 126(4):A-720.Paul J. Pockros, Mitchell L. Shiffman, Eugene R. Schiff, Nezam H. Afdhal, Mark S. Sulkowski, Zobair Younossi, Teresa Wright, Douglas T. Dieterich, Janice Jenkins, Gerhard J. Leitz, Peter J. Bowers. Gastroenterology2004126(4):A-720The Fate of Arterial Enhancing Nodules on MRI in the Cirrhotic Liver. Gastroenterology. 2004; 126(4):A-679.Valerie M. Byrnes, Honghu Shi, Shigeru Kiryu, Neil M. Rofsky, Nezam H. Afdhal . Gastroenterology2004126(4):A-679Des-Gamma Carboxyprothrombin (PIVKA-II)and Alfafetoprotein in Cirrhosis Secondary to HCV. Gastroenterology. 2004; 126(4):A-679.Brett D. Kalmowitz, Lorenzo Rossaro, Howard P. Monsour Jr., Robert S. Brown Jr., Mohamad A. El-Kurdi, K.R. Bhaskar, Nezam H. Afdhal . Gastroenterology2004126(4):A-679A Phase I/II Dose Escalation Trial Assessing Tolerance, Pharmacokinetics, and Antiviral Activity of NM283, a Novel Antiviral Treatment for Hepatitis C. Gastroenterology. 2004; 126(4):A-681.Eliot Godofsky, Nezam Afdhal, Vinod Rustgi, Lawton Shick, Lael Duncan, Xiao-Jian Zhou, George Chao, Christopher Fang, Barbara Fielman, Maureen Myers, Nathaniel Brown. Gastroenterology2004126(4):A-681The Outcome of Hepatitis C Therapy in African Americans and Hispanics with Persistently Normal Transaminases. Gastroenterology. 2004; 126(4):A-696.Eric J. Lawitz, Norma S. Cantu, Stephen A. Harrison, Shailesh Kadakia, Frank Adams, Mitchell Davis, Richard Sperling, Naoky Tsai, Andrei Gasic, Tarum Kothari, K.P. Ganeshappa, James Cox, Barry Sanders, Bruce Silverman, Elias Ghandour, Jeffrey Medoff, Nezam Afdhal, Mark Mailliard, Michael Curry, Alamo Study Group. Gastroenterology2004126(4):A-696Overexpression of Estrogen Receptor Alfa (ER-Alfa)Inhibits the Negative Feedback Regulation of Cholesterol (Ch) Biosynthesis and Increases Newly Synthesized Ch Leading to Biliary Ch Hypersecretion. Gastroenterology. 2004; 126(4):A-673.Helen H. Wang, Nezam H. Afdhal, David Q.H. Wang. Gastroenterology2004126(4):A-673The Effect of Amantadine on Sustained Virologic Response when Added to Pegylated Interferon Alfa 2b + Weight Based Ribavirin in Previous Nonresponders and Relapsers. Gastroenterology. 2004; 126(4):A-697.Eric J. Lawitz, Stephen A. Harrison, Norma S. Cantu, Shailesh C. Kadakia, K.P. Ganeshappa, Frank Adams, Mitchell Davis, Richard Sperling, Naoky Tsai, Andrei Gasic, Tarum Kothari, James Cox, Barry Sanders, Bruce Silverman, Elias Ghandour, Jeffrey Medoff, Vajravel Prasad, Nezam Afdhal, Mark Mailliard, Michael Curry, Alamo Study Group. Gastroenterology2004126(4):A-697Prospective Evaluation of a Serum (FibroSpect II) Panel to Predict Fibrosis in Chronic HCV Patients. Gastroenterology. 2004; 126(4):A-708-9.Keyur Patel, David R. Nelson, Nezam Afdhal, Esther Oh, Katie Smith, John G. McHutchison, Don Rockey. Gastroenterology2004126(4):A-708-9http://www.ncbi.nlm.nih.gov/pubmed/15081101Role of epoetin alfa in maintaining ribavirin dose. Gastroenterol Clin North Am. 2004 Mar; 33(1 Suppl):S25-35.Afdhal NH. Gastroenterol Clin North Am2004 Mar33(1 Suppl):S25-35http://www.ncbi.nlm.nih.gov/pubmed/15002984Interaction of mucin with cholesterol enriched vesicles: role of mucin structural domains. Biomacromolecules. 2004 Mar-Apr; 5(2):269-75.Afdhal NH, Cao X, Bansil R, Hong Z, Thompson C, Brown B, Wolf D. Biomacromolecules2004 Mar-Apr5(2):269-75http://www.ncbi.nlm.nih.gov/pubmed/14703511Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation. J Lipid Res. 2004 Mar; 45(3):438-47.Wang HH, Afdhal NH, Gendler SJ, Wang DQ. J Lipid Res2004 Mar45(3):438-47http://www.ncbi.nlm.nih.gov/pubmed/15118579Symptomatic focal nodular hyperplasia during pregnancy: a case report. Ann Hepatol. 2004 Jan-Mar; 3(1):35-7.Byrnes V, Cárdenas A, Afdhal N, Hanto D. Ann Hepatol2004 Jan-Mar3(1):35-7http://www.ncbi.nlm.nih.gov/pubmed/15346240The natural history of hepatitis C. Semin Liver Dis. 2004; 24 Suppl 2:3-8.Afdhal NH. Semin Liver Dis200424 Suppl 2:3-8Maintenance Therapies for Hepatitis C. Current Hepatitis Reports. 2004; 3:23-9.Kalmowitz BD, Afdhal NH. Current Hepatitis Reports20043:23-9http://www.ncbi.nlm.nih.gov/pubmed/14678990Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res. 2003 Dec 01; 63(23):8312-7.Yang C, Zeisberg M, Lively JC, Nyberg P, Afdhal N, Kalluri R. Cancer Res2003 Dec 0163(23):8312-7Hemoglobin Increase is Independently Associated with Increased Health-Related Quality of Life (HRQL)in Anemic Interferon/Ribavirin (IFN/RBV)-Treated Hepatitis C Virus (HCV)-Infected Patients Treated with Epoetin Alfa. Hepatology. 2003; 38(4):312A.Nezam H Afdhal, Angela Klopfer, Linda Tang, Zobair Younossi. Hepatology200338(4):312ATreatment of Chronic Hepatitis C with ISIS 14803, An Antisense Inhibitor of HCV, Given for 12 Weeks. Hepatology. 2003; 38(4):306-7A.Stuart C Gordon, Bruce R Bacon, Ira M Jacobson, Mitchell L Shiffman, Nezam H Afdhal, Rosie Z Yu, John G McHutchison, Jesse Kwoh. Hepatology200338(4):306-7AEpoetin Alfa (EPO) Improves and Maintains Health-Related Quality of Life (HRQL) in Anemic HCV-Infected Patients Receiving Interferon/Ribavirin (IFN/RBV): HRQL Results from the Proactive Study. Hepatology. 2003; 38(4):302-3A.Nezam h Afdhal, Betty Goon, Kevin Smith, Zobair Younossi. Hepatology200338(4):302-3ATriple Therapy Compared to Standard Pegylated Interferon Alfa 2B + Weight Based Ribavirin for Previous Nonresponders and Relapsers with Chronic Hepatitis C. Hepatology. 2003; 38(4):742A.Eric J Lawitz, Norma S Cantu, Mitchell Davis, Nezam Afdhal, Michael Curry, Mark Mailliard, Frank Adams, Naoky Tsai, Andrei Gasic, Tarun Kothari, K.P. Ganeshappa, James Cox, Bruce Silverman, Shailesh C Kadakia. Hepatology200338(4):742AEpithelial to Mesenchymal Transition During Liver Fibrosis. Hepatology. 2003; 38(4):332A.Changqing Yang, Jiyao Wang, Michael Zeisberg, Mary Soubasakos, Nezam H Afdhal, Raghu Kalluri. Hepatology200338(4):332AThe RENEW Trial: A National, Multicenter Study of High-Dose Peginterferon Alfa-2B + Ribavirin for Non-Responders with Hepatitis C. Hepatology. 2003; 38(4):312-13A.John B Gross, Terry M Therneau, Stephanie M Johnson, Paul Y Kwo, Nezam H Afdhal, Steven L Flamm, RENEW Trial Investigators. Hepatology200338(4):312-13ATriple Therapy Compared to Standard Pegylated Interferon Alfa 2B + Weight Based Ribavirin for Treatment Naive Chronic Hepatitis C [Tri-Star Trial]: Final Results. Hepatology. 2003; 38(4):636-7A.Eric J Lawitz, Norma S Cantu, Mitchell Davis, Nezam Afdhal, Michael Curry, Mark Mailliard, Frank AdamsNaoky TsaiTarun Kothari, K.P. Ganeshappa, James Cox, Bruce Silverman, Shailesh C Kadakia. Hepatology200338(4):636-7AThe Blockade of Estrogen Action by Fulvestrant (ICI 182,780) Prevents Cholesterol Gallstone Formation in the Mouse. Hepatology. 2003; 38(4):195A.Nezam H Afdhal, David Q Wang. Hepatology200338(4):195ARace, Insulin Resistance, Visceral Adiposity and Hepatic Steatosis in Genotype 1 Patients with Chronic Hepatitis C. Hepatology. 2003; 38(4):347A.Hari S Conjeevaram, David E Kleiner, Nezam Afdhal, Robert S Brown, Michael W Fried, Charles D Howell, Lennox J Jeffers, Nora Terrault, Thelma E Wiley, Chris Cherry, Steve Belle, Jay H Hoofnagle. Hepatology200338(4):347Ahttp://www.ncbi.nlm.nih.gov/pubmed/12717376Diagnosing fibrosis in hepatitis C: is the pendulum swinging from biopsy to blood tests? Hepatology. 2003 May; 37(5):972-4.Afdhal NH. Hepatology2003 May37(5):972-4Clinical Significance of Pegylated Interferon Induced Neutropenia: Results from the WIN-R Trial. Gastroenterology. 2003; 124(4):A-700.Furqaan Ahmed, Ira M. Jacobson, Robert S. Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederic Regenstein, David Bernstein, Robert Doig, Clifford Brass, WIN-R Study Group. Gastroenterology2003124(4):A-700Epoetin Alfa Treatment of Anemic HCV-infected Patients Allows for Maintenance of Ribavirin Dose, Increases Hemoglobin Levels, and Improves Quality of Life Vs Placebo: A Randomized, Double-blind, Multi-center Study. Gastroenterology. 2003; 124(4):A-714.Nezam H. Afdhal, Douglas T. Dieterich, Paul J. Pockros, Eugene R. Schiff, Mitchell L. Shiffman, Mark S. Sulkowski, Teresa Wright, Zobair Younossi, Peter J. Bowers. Gastroenterology2003124(4):A-714Effects of BMP-7 on Liver Regeneration after Partial Hepatectomy in Mice. Gastroenterology. 2003; 124(4):A-755.Changqing Yang, Hikaru Sugimoto, Sudhakar Akulppalli, Mauricio Giraldo, Nezam Afdhal, Michael Zeisberg, Raghu Kalluri. Gastroenterology2003124(4):A-755Targeted Disruption of Mucin Gene 1 (Muc1) Decreases Susceptibility to Cholesterol (Ch) Gallstone Formation in Mice. Gastroenterology. 2003; 124(4):A-698.Helen H. Wang, Nezam H. Afdhal, David Q.-H. Wang. Gastroenterology2003124(4):A-698Diseases of the Gallbladder and Bile Ducts. Cecils Textbook of Medicine Goldman L, Ed. 2003.Afdhal NH. Cecils Textbook of Medicine Goldman L, Ed2003AGA GTP Project 2003, Viral Hepatitis Section. 2003.Afdhal NH. AGA GTP Project 2003, Viral Hepatitis Section2003Hepatic Fibrosis. 2003.Afdhal NH. Hepatic Fibrosis2003http://www.ncbi.nlm.nih.gov/pubmed/12512039Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology. 2003 Jan; 124(1):147-59.Yang C, Zeisberg M, Mosterman B, Sudhakar A, Yerramalla U, Holthaus K, Xu L, Eng F, Afdhal N, Kalluri R. Gastroenterology2003 Jan124(1):147-59Characterictics of HCV Infection in African-Americans: Findings from the WIN-R Trial. Hepatology. 2002; 36(4):377A.Ira Jacobson, Robert S Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederic Regenstein, David Bernstein, Robert Doig, Clifford Brass. Hepatology200236(4):377ALiver Fibrosis: Extracellular Matrix Microenvironment Regulates Hepatocyte Behavior. Hepatology. 2002; 36(4):489A.Michael Zeisberg, Kyle Kramer, Changqing Yang, Nazia Akhtar, Nezam Afdhal, Raghu Kalluri. Hepatology200236(4):489AInterim Results in the RENEW Trial: A Dose Comparison Study of High-Dose PegInterferon Alfa-2B and Ribavirin for Interferon/Ribavirin Non-Responders with Chronic Hepatitis C. Hepatology. 2002; 36(4):359A.John B. Gross, Paul Kwo, Nezam Afdhal, RENEW Investigator Group. Hepatology200236(4):359AClinical Correlates of HCV Genotype and Viral Load: Findings from the WIN-R Trial. Hepatology. 2002; 36(4):376A.Ira Jacobson, Robert S Brown, Jr., Nezam Afdhal, Raymond Rubin, James Spivey, Bradley Freilich, Frederick Regenstein, David Bernstein, Robert Doig, Clifford Brass. Hepatology200236(4):376AA Phase II, 12-Week Study of ISIS 14083, An Antisense Inhibitor of HCV for the Treatment of Chronic Hepatitis C. Hepatology. 2002; 36(4):362A.S.C. Gordon, B.R. Bacon, I.M. Jacobson, M.L. Shiffman, N.H. Afdhal, J.G. McHutchison, T.J. Kwoh, F.A. Dorr. Hepatology200236(4):362ANew Insights into the Migratory Behavior of Human Hepatocellular Carcinoma HEPG2 Cells. Hepatology. 2002; 36(4):449A.Changqing Yang, Michael Zeisberg, Nezam Afdhal, Raghu Kalluri. Hepatology200236(4):449APotent Anti-HBV Activity of ACH-126,443 Correlated with 14-Day Pharmacokinetics and Safety: Predictions for Activity Against YMDD Mutant Strains. Hepatology. 2002; 36(4):372A.Nezam H Afdhal, Christopher B O'Brien, Scott C Oshana, Lisa M Dunkle. Hepatology200236(4):372ARacial/Ethnic Differences in Hematologic Toxicity of Pegylated Interferon and Ribavirin Therapy: Analysis of the Win-R Trial. Hepatology. 2002; 36(4):292A.Robert Brown, Ira Jacobson, Nezam Afdhal, Ray Rubin, James Spivey, Frederic Regenstein, David Bernstein, Clifford Brass, Bradley Freilich. Hepatology200236(4):292AComparison of Therapy with Peg-Intron 0.5mcg/kg Versus Colchicine 0.6mg BID in 250 Patients with Cirrhosis and HCV; Interim Data from Copilot. Hepatology. 2002; 36(4):312A.Nezam H. Afdhal, Bradley Freilich, Martin Black, Robert Levine, Clifford Brass. Hepatology200236(4):312ATransgenic Mice with 11 Beta-Hydroysteroid Dehydrogenase Type 1 Overexpression in Adipocytes Develop Fatty Liver Disease. Hepatology. 2002; 36(4):216A.Nezam H. Afdhal, Hiro Masuzaki, Bradley Turner, Imad Nasser, Jeffrey Flier. Hepatology200236(4):216ABone Morphogenic Protein-7, a Member of the TGF-Beta Superfamily, Accelerates Liver Regeneration After Partial Hepatectomy in Mice. Hepatology. 2002; 36(4):470A.Changqing Yang, Hikaru Sugimoto, Mauricio Giraldo, Nezam Afdhal, Michael Zeisberg, Raghu Kalluri. Hepatology200236(4):470ARegional and Racial Variation of Hepatitis C Genotypes in the United States. Hepatology. 2002; 36(4):711A.Vijayan Balan, Ira M Jacobson, Robert Brown, Jr., Nezam Afdhal, R Rubin, James Spivey, Bradley Freilich, David E Bernstein, Virender Sharma, Clifford Brass, WIN-R Study Group. Hepatology200236(4):711AIncreased Fecal Neutral Sterol and Bile Acid Excretion Confers Resistance to Diet-Induced Cholesterol (CH) Cholelithiasis in Gallstone-Resistant AKR Mice. Hepatology. 2002; 36(4):460A.Helen H Wang, Nezam H Afdhal, David Q Wang. Hepatology200236(4):460Ahttp://www.ncbi.nlm.nih.gov/pubmed/12202372A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems. Biophys J. 2002 Sep; 83(3):1465-78.Guo W, Kurze V, Huber T, Afdhal NH, Beyer K, Hamilton JA. Biophys J2002 Sep83(3):1465-78http://www.ncbi.nlm.nih.gov/pubmed/11879588Cholangiocarcinoma of the Hepatic Hilum (Klatskin Tumor). Curr Treat Options Gastroenterol. 2002 Apr; 5(2):87-94.Byrnes V, Afdhal N. Curr Treat Options Gastroenterol2002 Apr5(2):87-94http://www.ncbi.nlm.nih.gov/pubmed/11438511Good cholesterol, bad cholesterol: role of oxysterols in biliary tract diseases. Gastroenterology. 2001 Jul; 121(1):216-8.Wang DQ, Afdhal NH. Gastroenterology2001 Jul121(1):216-8http://www.ncbi.nlm.nih.gov/pubmed/11177689Hepatic fibrosis: are any of the serum markers useful? Curr Gastroenterol Rep. 2001 Feb; 3(1):12-8.Oh S, Afdhal NH. Curr Gastroenterol Rep2001 Feb3(1):12-8Hepatic adenoma. 2001.Curry MP, Afdhal NH. Hepatic adenoma2001Primary Care Medicine, 3rd Edition. Primary Care Medicine, 3rd Edition Noble J, Ed. 2001; 900-1026.Afdhal NH. Primary Care Medicine, 3rd Edition Noble J, Ed2001900-1026Biliary Tract Disease. Primary Care Medicine Noble J, Ed. 2001; 920-7.Afdhal NH. Primary Care Medicine Noble J, Ed2001920-7Formation and growth of cholesterol crystals in polymer solutions from model bile. Biophysical Journal (Poster presentation at the 45th annual meeting of the Biophysical Society, Boston, MA Feb. 17-21, 2001). 2001; 2(80):546a.Zhenning Hong, Rama Bansil, Nezam H. Afdhal, K. Ramakrishnan Bhaskar, Bradley S. Turner. Biophysical Journal (Poster presentation at the 45th annual meeting of the Biophysical Society, Boston, MA Feb. 17-21, 2001)20012(80):546aManagement of the Patient with Chronic Hepatitis. Chronic Viral Hepatitis; Diagnosis and Therapeutics, Wu GY, Koff RS, Eds. 2001; 211-32.Afdhal NH, Geahigan T. Chronic Viral Hepatitis; Diagnosis and Therapeutics, Wu GY, Koff RS, Eds2001211-32Pegylated (40kDa) Interferon Alfa-2a (PEGASYS) in Combination with Ribavirin , Mycophenolate Mofetil, Amantadine, or Amantadine plus Ribavirin in Patients that did not Respond to Rebetron Therapy: A Preliminary Report of a Randomized , Multicenter Study. Digestive Disease Week Presentation in Atlanta, Ga. 2001.Afdhal NH, Flamm S, Imperial JA, Malet PF, Tong M, Pappas SC, Campagna J. Digestive Disease Week Presentation in Atlanta, Ga2001Clinical Implications: Hepatitis in the New Millenium. Predictors of response to HCV. 2001.Afdhal NH. Clinical Implications: Hepatitis in the New Millenium. Predictors of response to HCV2001Atomic force microscopy of gastric mucin. Bulletin of the American Physical Society March poster presentation at the annual meeting of the American Physical Society, Seattle, WA. 2001; (46(1)):829.Bernard Chasan, Zhenning Hong, Rama Bansil, Bradley Turner, K. Ramakrishnan Bhaskar, Nezam Afdhal. Bulletin of the American Physical Society March poster presentation at the annual meeting of the American Physical Society, Seattle, WA2001(46(1)):829http://www.ncbi.nlm.nih.gov/pubmed/11068544An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C. Am J Clin Pathol. 2000 Nov; 114(5):712-8.O'Brien MJ, Keating NM, Elderiny S, Cerda S, Keaveny AP, Afdhal NH, Nunes DP. Am J Clin Pathol2000 Nov114(5):712-8Options for Non-responders to Combination Therapy. The Non-responding Hepatitis C Patient: Options and Variables, B. Bacon, Ed. 2000; 15-28.Afdhal NH. The Non-responding Hepatitis C Patient: Options and Variables, B. Bacon, Ed200015-28Diseases of the Gallbladder and Biliary Tract. Diseases of the Gallbladder and Biliary Tract N.H. Afdhal, Ed. 2000.N.H. Afdhal. Diseases of the Gallbladder and Biliary Tract N.H. Afdhal, Ed2000A 44 year old woman with sonographic evidence of gallstones. Internal Medicine Heffner JE, Sahn SA, Eds. 2000; 69-71.Keaveny AP, Afdhal NH. Internal Medicine Heffner JE, Sahn SA, Eds200069-71Randomized controlled trial of interferon A 5mU daily plus ribavirin 1000mg daily versus interferon A 3mU tiw plus ribavirin 1000mg daily in patients with HCV who have never received previous therapy. Hepatology. 2000; (32):363A.Afdhal NH, Brand M, Apstein A, Cooley J, Hoffman J, Mikolich D, Grace N, O'Connor C, Nunes DP. Hepatology2000(32):363ANon-invasive markers of hepatic fibrosis. 2000.Afdhal N.H., Curry MP. Non-invasive markers of hepatic fibrosis2000Hepatitis C treatment of patients in an urban medical center. Hepatology. 2000; (32):565A.Afdhal NH, Keaveny AP, Nunes DP. Hepatology2000(32):565AEpidemiology and Pathogenesis of Cholesterol Gallstones. Diseases of the Gallbladder and Biliary Tract Afdhal NH, Ed. 2000; 127-46.Afdhal NH. Diseases of the Gallbladder and Biliary Tract Afdhal NH, Ed2000127-46http://www.ncbi.nlm.nih.gov/pubmed/10701494Xenogeneic transplantation of porcine hepatocytes into the CCl4 cirrhotic rat model. Cell Transplant. 1999 Nov-Dec; 8(6):649-59.Stefan AM, Coulter S, Gray B, LaMorte W, Nikelaeson S, Edge AS, Afdhal NH. Cell Transplant1999 Nov-Dec8(6):649-59http://www.ncbi.nlm.nih.gov/pubmed/10235182Crohn's and stones. Am J Gastroenterol. 1999 May; 94(5):1130-2.Afdhal NH. Am J Gastroenterol1999 May94(5):1130-2http://www.ncbi.nlm.nih.gov/pubmed/10092316A recombinant bovine gallbladder mucin polypeptide binds biliary lipids and accelerates cholesterol crystal appearance time. Gastroenterology. 1999 Apr; 116(4):936-42.Nunes DP, Afdhal NH, Offner GD. Gastroenterology1999 Apr116(4):936-42http://www.ncbi.nlm.nih.gov/pubmed/10049309pH-dependent conformational change of gastric mucin leads to sol-gel transition. Biophys J. 1999 Mar; 76(3):1250-8.Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N, Afdhal NH. Biophys J1999 Mar76(3):1250-8Protecting New Jersey's Public Health; What healthcare professionals must know about hepatitis C. 1999.Afdhal N.H. Protecting New Jersey's Public Health; What healthcare professionals must know about hepatitis C1999Peripheral TH1 and TH2 cytokine responses in patients with HCV treated with interferon and interferon-ribavirin. Hepatology. 1999; (30):356A.Keaveny A, Cardenas A, Nunes DP, Edge AE, Afdhal NH. Hepatology1999(30):356ACholangitis in the immunosuppressed patient (AIDS Cholangiopathy). 1999.Raj V., Afdhal N.H. Cholangitis in the immunosuppressed patient (AIDS Cholangiopathy)1999Bacterial, Fungal and Granulomatous Diseases of the Liver. Therapy of Digestive Disorders Wolfe MM, Ed. 1999; 315-22.Afdhal NH. Therapy of Digestive Disorders Wolfe MM, Ed1999315-22Cystic diseases of biliary tract. 1999.Lowe R., Afdhal N.H. Cystic diseases of biliary tract1999Double blind placebo controlled study of interferon versus interferon plus ribavirin for the treatment of hepatitis C in patients who previously failed interferon monotherapy. Hepatology. 1999; (30):199A.Nunes DP, Anastopolous H, Gordon F, Chopra S, Petruff C, Salomons H, Wilson S, Afdhal NH. Hepatology1999(30):199AApproach to the patient with incidental gallstones. 1999.Afdhal N.H. Approach to the patient with incidental gallstones1999http://www.ncbi.nlm.nih.gov/pubmed/9790959The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem Biophys Res Commun. 1998 Oct 09; 251(1):350-5.Offner GD, Nunes DP, Keates AC, Afdhal NH, Troxler RF. Biochem Biophys Res Commun1998 Oct 09251(1):350-5http://www.ncbi.nlm.nih.gov/pubmed/9570570Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection. J Immunol. 1998 Feb 01; 160(3):1479-88.Wong DK, Dudley DD, Afdhal NH, Dienstag J, Rice CM, Wang L, Houghton M, Walker BD, Koziel MJ. J Immunol1998 Feb 01160(3):1479-88Treatment of acute cholecystitis. 1998.Zakko S., Afdhal N.H. Treatment of acute cholecystitis1998Epidemiology of and risk factors for gallstones. 1998.Lucas W., Afdhal N.H. Epidemiology of and risk factors for gallstones1998Acalculous cholecystitis. 1998.Afdhal N.H. Acalculous cholecystitis1998Inducible nitric oxide is the principal isoform expressed in human gallbladder. Gastroenterology. 1998; (114):526A.Keavney AP, Offner GD, Afdhal NH. Gastroenterology1998(114):526AHCV and HIV Co-infection. 1998.Afdhal N.H. HCV and HIV Co-infection1998Reduced sensitivity of HCV genotype 3 to interferon when co-infected with genotype 1. Gastroenterology. 1998; (114):1314A.Nunes DP, Offner GD, Afdhal NH. Gastroenterology1998(114):1314ACholangiocarcinoma. 1998.Lowe R., Afdhal N.H. Cholangiocarcinoma1998Serum cytokine profiles in patients with chronic HCV: Effect of interferon treatment. Hepatology. 1998; (28):364A.Nunes DP, Keaveny A, Gunsalus R, Lebel MD, Edge ASB, Offner GD, Afdhal NH. Hepatology1998(28):364AClinicians Companion I&II: Management of Hepatitis C. 1998.Afdhal N.H. Clinicians Companion I&II: Management of Hepatitis C1998Clinical features and diagnosis of acute cholecystitis. 1998.Zakko S., Afdhal N.H. Clinical features and diagnosis of acute cholecystitis1998The effect of iron depletion on serum markers of lipid peroxidation and fibrosis in hepatitis C. Hepatology. 1998; (28):568A.Tung BY, Afdhal NH, Nunes DP, Thummel KE, Kharasch ED, Croghan AM, Cox PP, Lin M, Kowdley KV. Hepatology1998(28):568ATNF-a stimulates mucin secretion, but not mucin synthesis in human gallbladder epithelial cells. Gastroenterology. 1998; (114):1238A.Eder MI, Nunes DP, Afdhal NH, Offner GD. Gastroenterology1998(114):1238AHuman spasmolytic polypeptide (hSP) significantly enhances the cholesterol crystal nucleating properties of mucin. Gastroenterology. 1998; (114):1313A.Nunes DP, Thim L, Niu N, Afdhal NH, Offner GD. Gastroenterology1998(114):1313Ahttp://www.ncbi.nlm.nih.gov/pubmed/9453424Urinary assays for desmosine and hydroxylysylpyridinoline in the detection of cirrhosis. J Hepatol. 1997 Dec; 27(6):993-1002.Afdhal NH, Keaveny AP, Cohen SB, Nunes DP, Maldonado N, O'Brien M, Stone PJ. J Hepatol1997 Dec27(6):993-1002http://www.ncbi.nlm.nih.gov/pubmed/9336189Diffusion behavior of lipid vesicles in entangled polymer solutions. Biophys J. 1997 Oct; 73(4):1932-9.Cao X, Bansil R, Gantz D, Moore EW, Niu N, Afdhal NH. Biophys J1997 Oct73(4):1932-9http://www.ncbi.nlm.nih.gov/pubmed/9164870Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem J. 1997 May 15; 324 ( Pt 1):295-303.Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Biochem J1997 May 15324 ( Pt 1):295-303http://www.ncbi.nlm.nih.gov/pubmed/9142907Nitric oxide and gallbladder motility in prairie dogs. Am J Physiol. 1997 Apr; 272(4 Pt 1):G770-8.Salomons H, Keaveny AP, Henihan R, Offner G, Sengupta A, Lamorte WW, Afdhal NH. Am J Physiol1997 Apr272(4 Pt 1):G770-8Complications of laparoscopic cholecystectomy. 1997.Afdhal N.H. Complications of laparoscopic cholecystectomy1997Mucin vesicle interactions are biphasic and depend on mucin glycosylated and non-glycosylated structural domains. Gastroenterology. 1997; (112):1237A.Cao X, Niu N, Offner GD, Nunes D, Bansil R, Wolf DE, Afdhal NH. Gastroenterology1997(112):1237AAcute Cholangitis, Up to Date in Medicine, Gastroenterology Series. 1997.Raj V, Afdhal N.H. Acute Cholangitis, Up to Date in Medicine, Gastroenterology Series1997Colorectal Cancer Screening, Core Curriculum in Medicine. 1997.Afdhal N.H. Colorectal Cancer Screening, Core Curriculum in Medicine1997Pancreatic and Hepatobiliary Infections in AIDS Patients. Gastrointestinal Infections LaMont JT, Ed. 1997; 361-97.Keaveny A, Karasik M, Afdhal NH. Gastrointestinal Infections LaMont JT, Ed1997361-97Small Bowel and Colonic Infections in AIDS Patients. Gastrointestinal Infections LaMont JT, Ed. 1997; 191-247.Karasik M, Afdhal NH. Gastrointestinal Infections LaMont JT, Ed1997191-247Substance P is not a neuromediator of splanchnic hyperemia or portal hypertension in the cirrhotic rat. Gastroenterology. 1997; (112):1324A.Lowe R, Bodkin S, Kenney T, Afdhal NH. Gastroenterology1997(112):1324AWhat prevents digestion of the gallbladder? Phospholipid protects against the toxic effect of taurochenodeoxycholate but not taurocholate. Gastroenterology. 1997; (112):1337A.Moore EW, Darby GH, Rege RV, Afdhal NH. Gastroenterology1997(112):1337AGallstone Ileus. 1997.Keavney A., Afdhal N.H. Gallstone Ileus1997Abnormal liver function tests for the Primary Care Physician, Core Curriculum in Medicine. 1997.Afdhal N.H. Abnormal liver function tests for the Primary Care Physician, Core Curriculum in Medicine1997http://www.ncbi.nlm.nih.gov/pubmed/8979052The acute and long-term effect of balloon sphincteroplasty on papillary structure in pigs. Gastrointest Endosc. 1996 Dec; 44(6):650-5.Mac Mathuna P, Siegenberg D, Gibbons D, Gorin D, O'Brien M, Afdhal NA, Chuttani R. Gastrointest Endosc1996 Dec44(6):650-5http://www.ncbi.nlm.nih.gov/pubmed/8677989Feasibility of high-volume screening sigmoidoscopy using a flexible fiberoptic endoscope and a disposable sheath system. Am J Gastroenterol. 1996 Jul; 91(7):1331-7.Schroy PC, Wilson S, Afdhal N. Am J Gastroenterol1996 Jul91(7):1331-7http://www.ncbi.nlm.nih.gov/pubmed/8964420The pronase resistance of cholesterol-nucleating glycoproteins in human bile. Gastroenterology. 1996 Jun; 110(6):1926-35.Zijlstra AI, Offner GD, Afdhal NH, van Overveld M, Tytgat GN, Groen AK. Gastroenterology1996 Jun110(6):1926-35Gastrointestinal Manifestations of AIDS. HIV Infection: A Clinical Manual Libman H, Witzburg RA, Eds. 1996; 165-80.Karasik M, Afdhal NH. HIV Infection: A Clinical Manual Libman H, Witzburg RA, Eds1996165-80Acalculous cholecystitis. Consultations in Gastroenterology Snape WJ, Ed. 1996; 853-7.Afdhal NH, Nunes D. Consultations in Gastroenterology Snape WJ, Ed1996853-7Biliary Tract Disease. Primary Care Medicine Noble J, Ed. 1996; 605-13.Karasik M, Afdhal NH. Primary Care Medicine Noble J, Ed1996605-13Randomized trial of interferon dose escalation for the treatment of chronic hepatitis C. Gastroenterology. 1996; (110):1281A.Nunes D, Sharma A, Cohen S, Rea C, Offner GD, Apstein M, Afdhal NH. Gastroenterology1996(110):1281AWhat prevents the gallbladder from digesting itself? Studies of taurochenodeoxycholate toxicity. Gastroenterology. 1996; (110):1268A.Moore EW, Darby G, Afdhal NH. Gastroenterology1996(110):1268AAlterations in gallbladder mucin gene expression in patients with cholesterol gallstones. Gastroenterology. 1996; (110):1282A54.Offner GD, Nunes DP, Zhang F, McAnany DB, Afdhal NH. Gastroenterology1996(110):1282A54http://www.ncbi.nlm.nih.gov/pubmed/7557151Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation. Gastroenterology. 1995 Nov; 109(5):1661-72.Afdhal NH, Ostrow JD, Koehler R, Niu N, Groen AK, Veis A, Nunes DP, Offner GD. Gastroenterology1995 Nov109(5):1661-72http://www.ncbi.nlm.nih.gov/pubmed/7593618HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest. 1995 Nov; 96(5):2311-21.Koziel MJ, Dudley D, Afdhal N, Grakoui A, Rice CM, Choo QL, Houghton M, Walker BD. J Clin Invest1995 Nov96(5):2311-21http://www.ncbi.nlm.nih.gov/pubmed/7657293Mucin-vesicle interactions in model bile: evidence for vesicle aggregation and fusion before cholesterol crystal formation. Hepatology. 1995 Sep; 22(3):856-65.Afdhal NH, Niu N, Nunes DP, Bansil R, Cao XX, Gantz D, Small DM, Offner GD. Hepatology1995 Sep22(3):856-65http://www.ncbi.nlm.nih.gov/pubmed/7646470Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats. Biochem J. 1995 Aug 15; 310 ( Pt 1):41-8.Nunes DP, Keates AC, Afdhal NH, Offner GD. Biochem J1995 Aug 15310 ( Pt 1):41-8Acute hyperglycemia impairs gallbladder motility in normal but not diabetic men. American Journal of Gastroenterology. 1995; (90):1606.Karasik M, Dunzendorfer T, Lee V, Chipkin S, Afdhal NH. American Journal of Gastroenterology1995(90):1606HIDA scintigraphy as a test for small intestinal transit: Effect of acute hyperglycemia. American Journal of Gastroenterology. 1995; (90):1631.Duzendorfer D, Lee V, Chipkin S, Afdhal NH, Karasik M. American Journal of Gastroenterology1995(90):1631New Perspectives on Gallstone Pathogenesis and Prevention. Journal of the Irish Colleges of Physicians and Surgeons. 1995; 24:267-78.Afdhal NH, Carey MC. Journal of the Irish Colleges of Physicians and Surgeons199524:267-78Prostaglandin E1 stimulates mucin secretion and increases MUC3 mRNA levels in cultured human gallbladder epithelial cells. Hepatology. 1995; (22):110.Offner GD, Nunes DP, Moore EW, Afdhal NH. Hepatology1995(22):110Effect of substance P and its receptor antagonist CP-96,345 on systemic arterial and portal pressure in normal and cirrhotic rats. Hepatology. 1995; (22):258.Kenney TJ, Stefan A, Nunes DP, Offner GD, Nikulasson S, Pouthalakis C and Afdhal NH. Hepatology1995(22):258http://www.ncbi.nlm.nih.gov/pubmed/7907074Identification of a 130-kilodalton human biliary concanavalin A binding protein as aminopeptidase N. Gastroenterology. 1994 Mar; 106(3):755-62.Offner GD, Gong D, Afdhal NH. Gastroenterology1994 Mar106(3):755-62Interaction of biliary cholesterol with mucin gels. Gastroenterology. 1994; (106):925A.Lataif LE, Niu N, Offner GD, Afdhal NH. Gastroenterology1994(106):925APathogenesis of Gallstones. Principles and Practices of Gastroenterology and Hepatology, Gitnick G, Ed. 1994; 561-571.Afdhal NH, LaMont JT. Principles and Practices of Gastroenterology and Hepatology, Gitnick G, Ed1994561-571Effect of mucus gel layer on phospholipid transfer across human cultured gallbladder epithelia. Hepatology. 1994; (20):115.Purdum PP, Afdhal NH, Rege R, Moore EW. Hepatology1994(20):115Cholesterol Gallstone Disease: From Pathogenesis to Prevention. Current Opinion in Gastroenterology. 1994; 10:523-5.LaMont JT, Afdhal NH. Current Opinion in Gastroenterology199410:523-5http://www.ncbi.nlm.nih.gov/pubmed/7693974Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol. 1993 Dec; 67(12):7522-32.Koziel MJ, Dudley D, Afdhal N, Choo QL, Houghton M, Ralston R, Walker BD. J Virol1993 Dec67(12):7522-32http://www.ncbi.nlm.nih.gov/pubmed/8482197Squamous metaplasia of extrahepatic biliary system in an AIDS patient with cryptosporidia and cholangitis. Dig Dis Sci. 1993 May; 38(5):960-2.Kline TJ, De las Morenas T, O'Brien M, Smith BF, Afdhal NH. Dig Dis Sci1993 May38(5):960-2http://www.ncbi.nlm.nih.gov/pubmed/8482463Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Gastroenterology. 1993 May; 104(5):1515-23.Afdhal NH, Niu N, Gantz D, Small DM, Smith BF. Gastroenterology1993 May104(5):1515-23http://www.ncbi.nlm.nih.gov/pubmed/8477974Cholesterol cholelithiasis in the prairie dog: role of mucin and nonmucin glycoproteins. Hepatology. 1993 Apr; 17(4):693-700.Afdhal NH, Gong D, Niu N, Turner B, LaMont JT, Offner GD. Hepatology1993 Apr17(4):693-700Gastrointestinal manifestations of the Acquired Immunodeficiency Syndrome. HIV Infection: A Clinical Manual Libman H, Witzburg R, Eds. 1993; 146-159.Afdhal NH. HIV Infection: A Clinical Manual Libman H, Witzburg R, Eds1993146-159Acute hyperglycemia impairs gallbladder and small intestinal motility in normal men. Gastroenterology. 1993; (104):530.Karasik MS, Dunzendorfer T, Lee V, Chipkin S, Afdhal NH. Gastroenterology1993(104):530Molecular basis of nucleation: differences between slow and fast pro-nucleating proteins. Gastroenterology. 1993; (104):867.Afdhal NH, Niu N, Nunes D, Bansil R, Gantz D, Small DM, Offner GD. Gastroenterology1993(104):867http://www.ncbi.nlm.nih.gov/pubmed/1568656Postprandial changes in portal haemodynamics in patients with cirrhosis. Gut. 1992 Mar; 33(3):364-7.O'Brien S, Keogan M, Patchett S, McCormick PA, Afdhal N, Hegarty JE. Gut1992 Mar33(3):364-7http://www.ncbi.nlm.nih.gov/pubmed/2007362Controlled trial of antimycobacterial therapy in Crohn's disease. Clofazimine versus placebo. Dig Dis Sci. 1991 Apr; 36(4):449-53.Afdhal NH, Long A, Lennon J, Crowe J, O'Donoghue DP. Dig Dis Sci1991 Apr36(4):449-53Calcium preferentially accelerates gallbladder mucin induced cholesterol monohydrate crystal nucleation rather than crystal growth in model bile. Gastroenterology. 1991; (100):781.Niu N, Smith BF, Small DM, Afdhal NH. Gastroenterology1991(100):781http://www.ncbi.nlm.nih.gov/pubmed/2210258Characterization of bovine gallbladder mucin. Amino acid sequences of tryptic peptides from the glycosylated domain of the protein core. Gastroenterology. 1990 Nov; 99(5):1493-501.Afdhal NH, Offner GD, Smith BF. Gastroenterology1990 Nov99(5):1493-501http://www.ncbi.nlm.nih.gov/pubmed/2186955Isolation and characterization of peptides from the protein core of bovine gallbladder mucin. Gastroenterology. 1990 Jun; 98(6):1633-41.Afdhal NH, Offner GD, Murray FE, Troxler RF, Smith BF. Gastroenterology1990 Jun98(6):1633-41http://www.ncbi.nlm.nih.gov/pubmed/2184117Cholesterol crystal nucleation: a decade-long search for the missing link in gallstone pathogenesis. Hepatology. 1990 Apr; 11(4):699-702.Afdhal NH, Smith BF. Hepatology1990 Apr11(4):699-702Pathogenesis of Cholesterol Gallstones. Viewpoints on Digestive Disease. 1990; 22:13-18.Afdhal NH, Smith BF. Viewpoints on Digestive Disease199022:13-18Calcium augments binding of bilirubin to bovine gallbladder mucin. Hepatology. 1990; 12:899.Gourdin TG, Afdhal NH, Niu N, Smith BF. Hepatology199012:899http://www.ncbi.nlm.nih.gov/pubmed/2612985Clot lysis by gastric juice: an in vitro study. Gut. 1989 Dec; 30(12):1704-7.Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP. Gut1989 Dec30(12):1704-7http://www.ncbi.nlm.nih.gov/pubmed/2778940Remission induction in refractory Crohns disease using a high calorie whole diet. JPEN J Parenter Enteral Nutr. 1989 Jul-Aug; 13(4):362-5.Afdhal NH, Kelly J, McCormick PA, O'Donoghue DP. JPEN J Parenter Enteral Nutr1989 Jul-Aug13(4):362-5http://www.ncbi.nlm.nih.gov/pubmed/3395828Conservative management of perforated duodenal ulcer. Br J Surg. 1988 Jun; 75(6):583-4.Keane TE, Dillon B, Afdhal NH, McCormack CJ. Br J Surg1988 Jun75(6):583-4http://www.ncbi.nlm.nih.gov/pubmed/3391755Serological markers of hepatitis B virus (HBV) infection in alcoholics and hospital controls. Ir J Med Sci. 1988 Mar; 157(3):77-8.McCormick PA, Ramsay N, Afdhal N, Shattuck AG, Hillary IB, Tubridy D, O'Donoghue DP. Ir J Med Sci1988 Mar157(3):77-8A Colorectal Cancer Database. Computers in Gastroenterology Vickery R, Editor. 1988.Bulger K, Afdhal NH, O'Donoghue DP. Computers in Gastroenterology Vickery R, Editor1988http://www.ncbi.nlm.nih.gov/pubmed/3297939Immunohistochemical Cal9-9 in primary colonic polyps and polyps synchronous with colorectal cancer. Gut. 1987 May; 28(5):594-600.Afdhal NH, Long A, Tobbia I, Cullen A, O'Donoghue DP. Gut1987 May28(5):594-600http://www.ncbi.nlm.nih.gov/pubmed/3733401Carbohydrate handling by colonic flora--is it pathogenic in the irritable bowel syndrome? Ir J Med Sci. 1986 Jun; 155(6):197-201.Afdhal NH, Piggott C, Long AA, O'Donoghue DP. Ir J Med Sci1986 Jun155(6):197-201http://www.ncbi.nlm.nih.gov/pubmed/3865919Ca-19-9, a new marker for gastrointestinal malignancy. Ir J Med Sci. 1985 Oct; 154(10):385-6.Duffy MJ, O'Sullivan F, O'Donoghue D, Afdhal NH, Kelleher D. Ir J Med Sci1985 Oct154(10):385-6http://www.ncbi.nlm.nih.gov/pubmed/3997447Obstructive sleep apnoea syndrome presenting as cardiac arrhythmia. Ir J Med Sci. 1985 Mar; 154(3):120-3.Afdhal NH, Chman M, Doyle D, Horgan JH. Ir J Med Sci1985 Mar154(3):120-3http://www.ncbi.nlm.nih.gov/pubmed/6735681Acute small bowel obstruction secondary to endometriosis: two case reports and a review of the literature. Ir Med J. 1984 May; 77(5):141-3.Afdhal NH, Smith J, Heffernan S, Doyle JS, Gaffney E. Ir Med J1984 May77(5):141-3http://www.ncbi.nlm.nih.gov/pubmed/6668172Vitamin B1, B2, B6 and C status in the elderly. Ir Med J. 1983 Dec; 76(12):488-90.Keatinge AM, Johnson AH, Collins PB, Afdhal N, Lynch D, Lavin JN. Ir Med J1983 Dec76(12):488-90Hepatitis C, Chronic931.043246942033998e+0011998-02-01T00:00:002020-08-22T00:00:00Liver Cirrhosis1059.485092480004051e+0001992-03-01T00:00:002022-09-09T00:00:00Antiviral Agents796.455209492956469e+0002004-03-01T00:00:002022-11-11T00:00:00Ribavirin485.352792708937224e+0002004-03-01T00:00:002018-04-26T00:00:00Elasticity Imaging Techniques254.710019388336949e+0002007-10-01T00:00:002024-09-06T00:00:00Hepacivirus554.249464182210623e+0001995-11-01T00:00:002021-06-09T00:00:00Fluorenes163.932648989637245e+0002014-04-11T00:00:002017-07-10T00:00:00Uridine Monophosphate153.197119753996287e+0002013-03-15T00:00:002017-05-01T00:00:00Hepatitis C323.164399248842098e+0001993-12-01T00:00:002021-06-09T00:00:00Benzimidazoles182.831784721908405e+0002014-04-11T00:00:002017-07-10T00:00:00Sofosbuvir232.813672042061782e+0002013-03-15T00:00:002020-08-22T00:00:00Non-alcoholic Fatty Liver Disease302.429760887536671e+0002012-04-24T00:00:002024-11-29T00:00:00Thrombocytopenia142.276337333327408e+0002004-03-01T00:00:002021-02-12T00:00:00Liver Diseases132.089958079764926e+0002006-01-01T00:00:002024-09-06T00:00:00Hepatitis B, Chronic102.022499568451273e+0002007-09-24T00:00:002022-11-11T00:00:00Interferon-alpha311.866808597456149e+0002004-03-01T00:00:002015-08-01T00:00:00Liver521.695542728809534e+0001993-04-01T00:00:002024-09-06T00:00:00Alanine Transaminase171.516178730482452e+0002005-04-13T00:00:002017-02-12T00:00:00Benzoates51.472953597797714e+0002007-11-29T00:00:002014-05-27T00:00:00Hydrazines51.459676427972449e+0002007-11-29T00:00:002014-05-27T00:00:00Polyethylene Glycols271.295443515546825e+0002004-03-01T00:00:002015-08-01T00:00:00Fatty Liver141.280229075457594e+0002005-03-24T00:00:002024-11-29T00:00:00Cinnamates21.265996749885815e+0002019-03-15T00:00:002021-02-12T00:00:00Receptors, Thrombopoietin61.244440704294386e+0002007-11-01T00:00:002021-02-12T00:00:00Genotype321.243060999385428e+0001998-02-01T00:00:002021-06-09T00:00:00Hematologic Agents31.197378979368958e+0002013-03-04T00:00:002014-05-27T00:00:00Carcinoma, Hepatocellular141.131878878216645e+0002003-12-01T00:00:002021-12-30T00:00:00Interleukins91.101120195448656e+0002010-04-24T00:00:002012-07-01T00:00:00Interferons141.060086980865724e+0002004-03-01T00:00:002017-04-26T00:00:00Postoperative Hemorrhage29.598504159377783e-0012019-03-15T00:00:002021-02-12T00:00:00Blood Loss, Surgical29.343763897999360e-0012019-03-15T00:00:002021-02-12T00:00:00Liver Neoplasms159.251026489615706e-0012003-12-01T00:00:002021-12-30T00:00:00Platelet Transfusion39.151900445528772e-0012007-11-01T00:00:002021-02-12T00:00:00Interferon alpha-2249.134709662425601e-0012004-03-01T00:00:002015-08-01T00:00:00Drug Therapy, Combination358.716508789787237e-0012004-03-01T00:00:002018-04-17T00:00:00Mucins158.664820334796236e-0011990-04-01T00:00:002006-07-01T00:00:00Liver Transplantation108.500116129039245e-0012005-04-01T00:00:002017-05-01T00:00:00Biopsy358.471585040540981e-0012000-11-01T00:00:002021-12-01T00:00:00Viral Load188.447571613077091e-0012004-05-01T00:00:002017-04-10T00:00:00Hypertension, Portal67.742638789459150e-0011992-03-01T00:00:002021-12-01T00:00:00Pyrazoles57.545397708538282e-0012007-11-29T00:00:002014-05-27T00:00:00Thiazoles27.510946070549800e-0012019-03-15T00:00:002021-02-12T00:00:00Aspartate Aminotransferases117.340851497730275e-0012005-04-25T00:00:002015-04-27T00:00:00Gallbladder147.283203665397621e-0011990-06-01T00:00:002006-07-01T00:00:00RNA, Viral197.209071313782832e-0012005-04-13T00:00:002018-04-17T00:00:00Cholesterol186.976021938762838e-0011990-04-01T00:00:002021-12-07T00:00:00Hyaluronic Acid96.520100327702114e-0012001-02-01T00:00:002013-06-05T00:00:00Proline46.482518242378220e-0012012-05-01T00:00:002015-05-25T00:00:00Hepatitis B36.361093212409488e-0011988-03-01T00:00:002022-11-11T00:00:00Esophageal and Gastric Varices36.250577714825543e-0012010-06-24T00:00:002010-10-07T00:00:00Recombinant Proteins336.037354512385064e-0011993-12-01T00:00:002015-08-01T00:00:00Drug Interactions25.968495072695401e-0012016-10-05T00:00:002021-06-09T00:00:00Portal Pressure35.957377914197852e-0012017-04-10T00:00:002021-12-01T00:00:00Gastric Mucins55.946214179341577e-0011999-03-01T00:00:002009-08-11T00:00:00Cholelithiasis85.743297616879582e-0011990-04-01T00:00:002006-07-01T00:00:00Imidazoles45.697124392260368e-0012017-12-26T00:00:002022-09-09T00:00:00Hepatic Veins25.449876794043194e-0012017-04-10T00:00:002019-05-28T00:00:00Bile105.441131315280162e-0011990-04-01T00:00:002005-12-27T00:00:00Humans2375.429114260021712e-0011983-12-01T00:00:002024-11-29T00:00:00Middle Aged1275.380039178235917e-0011985-03-01T00:00:002024-11-29T00:00:00Benzofurans15.290164587955422e-0012018-04-17T00:00:002018-04-17T00:00:00Sustained Virologic Response75.137011622797644e-0012016-06-11T00:00:002020-08-22T00:00:00Hematinics55.039555020621699e-0012004-03-01T00:00:002013-02-11T00:00:00Vibration35.020358634727060e-0012014-06-05T00:00:002015-08-25T00:00:00Male1515.005889002933288e-0011985-03-01T00:00:002024-11-29T00:00:00Drug Therapy14.903704401023825e-0012019-07-01T00:00:002019-07-01T00:00:00Oligopeptides44.858104054795431e-0012010-04-08T00:00:002015-05-25T00:00:00Quinoxalines14.845209753496116e-0012018-04-17T00:00:002018-04-17T00:00:00Hepatitis B e Antigens64.838837857468878e-0012007-09-24T00:00:002022-11-11T00:00:00Biomarkers314.829904825780214e-0012001-02-01T00:00:002024-11-29T00:00:00Female1504.707766896472147e-0011984-05-01T00:00:002024-11-29T00:00:00Tenofovir64.673302786976110e-0012012-12-10T00:00:002022-11-11T00:00:00Silymarin64.573383584510118e-0012004-11-01T00:00:002012-07-18T00:00:00Adult1074.554826194801532e-0011984-05-01T00:00:002024-11-29T00:00:00Histocytochemistry34.540277530105662e-0012008-01-09T00:00:002017-02-12T00:00:00End Stage Liver Disease44.496096276068974e-0012017-05-01T00:00:002021-12-30T00:00:00Keratin-1834.488471605357275e-0012009-04-01T00:00:002016-02-24T00:00:00Neurocognitive Disorders14.434614731254027e-0012017-04-26T00:00:002017-04-26T00:00:00Erythropoietin54.433299233755242e-0012004-03-01T00:00:002013-08-04T00:00:00Drug Administration Schedule94.386590068264716e-0012005-02-01T00:00:002019-03-15T00:00:00Disease Progression264.382901256175216e-0012004-01-01T00:00:002022-09-09T00:00:00Diagnostic Tests, Routine34.340116856301486e-0012004-06-01T00:00:002014-06-05T00:00:00Chronic Disease134.297016863185706e-0011993-12-01T00:00:002024-09-06T00:00:00Cost-Benefit Analysis74.295612364366548e-0012004-09-01T00:00:002017-05-01T00:00:00Hepatitis, Viral, Human34.295200099502426e-0012005-11-28T00:00:002015-01-01T00:00:00Protease Inhibitors24.283058070855124e-0012012-05-01T00:00:002015-05-25T00:00:00Liver Cirrhosis, Experimental24.282125581145340e-0011999-11-01T00:00:002008-03-01T00:00:00Hepatic Encephalopathy24.223448077815975e-0012014-06-04T00:00:002018-03-11T00:00:00Severity of Illness Index244.202581290032801e-0012004-06-01T00:00:002021-12-07T00:00:00Clinical Laboratory Techniques14.136783024143187e-0012019-04-01T00:00:002019-04-01T00:00:00Nucleosides14.126134388877297e-0012014-08-11T00:00:002014-08-11T00:00:00Treatment Outcome434.002838053356197e-0012005-04-13T00:00:002022-11-11T00:00:00Interferon Lambda93.883171288533194e-0012010-04-24T00:00:002012-07-01T00:00:00Predictive Value of Tests173.820680173032060e-0012005-04-25T00:00:002016-03-15T00:00:00Hepatitis, Chronic23.791761720909906e-0012011-07-01T00:00:002016-01-07T00:00:00Cystadenocarcinoma13.737565604239266e-0012012-05-01T00:00:002012-05-01T00:00:00Platelet Count93.722940628697817e-0012006-04-01T00:00:002014-10-14T00:00:00Perioperative Care13.650268630425028e-0012021-02-12T00:00:002021-02-12T00:00:00Nucleotides13.575052902164579e-0012014-08-11T00:00:002014-08-11T00:00:00Antidiuretic Hormone Receptor Antagonists13.542011983510293e-0012011-10-23T00:00:002011-10-23T00:00:00Proton Pump Inhibitors13.434109531705650e-0012016-10-05T00:00:002016-10-05T00:00:00Biopsy, Needle63.395339230913236e-0012004-06-01T00:00:002012-12-10T00:00:00Liver Circulation33.393758272765927e-0011992-03-01T00:00:002008-03-01T00:00:00Point-of-Care Systems23.292026182075627e-0012014-06-05T00:00:002024-09-06T00:00:00Gallstones43.290625780733448e-0012004-01-01T00:00:002010-06-01T00:00:00Clinical Enzyme Tests13.287847943712844e-0012010-09-01T00:00:002010-09-01T00:00:00Deep Learning13.157504308077196e-0012024-09-06T00:00:002024-09-06T00:00:00Aged593.146129466059006e-0011983-12-01T00:00:002021-10-26T00:00:00Tissue Inhibitor of Metalloproteinase-133.063768330343969e-0012005-03-01T00:00:002009-04-01T00:00:00Fibrosis93.057554463827504e-0012006-04-01T00:00:002024-03-22T00:00:00Benzazepines13.051382026377245e-0012011-10-23T00:00:002011-10-23T00:00:00Liver Function Tests72.998287917620947e-0012004-05-01T00:00:002011-11-30T00:00:00Portasystemic Shunt, Transjugular Intrahepatic12.959276771770498e-0012010-06-24T00:00:002010-06-24T00:00:00Hyponatremia12.926757704996227e-0012011-10-23T00:00:002011-10-23T00:00:00ROC Curve122.898333188817694e-0012006-10-01T00:00:002021-12-01T00:00:00Basal Ganglia12.864959979177436e-0012011-10-23T00:00:002011-10-23T00:00:00Intracranial Hemorrhages12.858240538761976e-0012014-06-04T00:00:002014-06-04T00:00:00Dose-Response Relationship, Drug132.842420167453320e-0011997-04-01T00:00:002019-03-15T00:00:00Carbamates32.808445814703273e-0012009-12-01T00:00:002016-07-20T00:00:00Methylene Blue22.787128815332843e-0011997-04-01T00:00:002007-02-17T00:00:00Isoindoles12.775642490783382e-0012008-03-01T00:00:002008-03-01T00:00:00Anthropometry12.763656278919278e-0012012-12-20T00:00:002012-12-20T00:00:00Viral Nonstructural Proteins62.749584597036496e-0011998-02-01T00:00:002016-12-05T00:00:00Cholestasis, Intrahepatic32.748848684055424e-0012008-01-09T00:00:002015-05-15T00:00:00Prognosis182.731868261786920e-0011988-06-01T00:00:002021-12-01T00:00:00Angiotensin II Type 1 Receptor Blockers12.669473445236176e-0012010-07-01T00:00:002010-07-01T00:00:00Gastroenterology12.648095806307851e-0012014-06-05T00:00:002014-06-05T00:00:00Adenosine Deaminase22.639281247545680e-0012017-11-21T00:00:002021-10-26T00:00:00Anemia82.636848891774508e-0012004-03-01T00:00:002013-08-04T00:00:00Hemangioma12.619879379312570e-0012012-05-01T00:00:002012-05-01T00:00:00Diagnostic Techniques, Digestive System12.537367465254733e-0012007-01-29T00:00:002007-01-29T00:00:00Substance P12.534976863128247e-0012008-03-01T00:00:002008-03-01T00:00:00Gastric Mucosa22.478841594187234e-0012005-11-01T00:00:002009-08-11T00:00:00Confidence Intervals32.474324449614003e-0012012-07-01T00:00:002019-03-15T00:00:00Sensitivity and Specificity152.473497083904199e-0012004-06-01T00:00:002016-03-15T00:00:00Administration, Oral72.422760710704646e-0012007-08-01T00:00:002019-03-15T00:00:00DNA, Viral42.413136933114141e-0012008-12-01T00:00:002022-11-11T00:00:00Health Care Costs32.395493239422587e-0012013-04-01T00:00:002015-12-30T00:00:00Crystallization102.375358040492353e-0011990-04-01T00:00:002010-06-01T00:00:00Nitric Oxide Synthase22.367679818693370e-0011997-04-01T00:00:002007-02-17T00:00:00Dipeptidyl-Peptidase IV Inhibitors12.363440781780178e-0012010-07-01T00:00:002010-07-01T00:00:00Double-Blind Method192.343962882988214e-0011991-04-01T00:00:002019-03-15T00:00:00Schistosomiasis12.311197630585791e-0012006-04-01T00:00:002006-04-01T00:00:00Frontal Lobe12.274996589963056e-0012011-10-23T00:00:002011-10-23T00:00:00Glycoproteins62.251728399142665e-0011993-04-01T00:00:002009-04-01T00:00:00Drug Design12.233792676906793e-0012010-07-01T00:00:002010-07-01T00:00:00Collagen Type III12.208262615062972e-0012005-03-01T00:00:002005-03-01T00:00:00United States232.205012849610164e-0012005-04-01T00:00:002024-11-29T00:00:00Biochemistry12.194832481966035e-0012005-11-01T00:00:002005-11-01T00:00:00Retrospective Studies202.192730132816723e-0012006-08-01T00:00:002022-09-09T00:00:00Hepatitis B virus22.183429824294532e-0012012-12-10T00:00:002022-11-11T00:00:00Endosonography12.179900860187415e-0012009-03-01T00:00:002009-03-01T00:00:00Cohort Studies162.155797815008266e-0011998-02-01T00:00:002024-11-29T00:00:00Drug Resistance, Viral52.152396659805470e-0012011-08-24T00:00:002016-12-05T00:00:00Benzamides32.131998070892278e-0012017-12-26T00:00:002022-09-09T00:00:00Guanine22.131312451693690e-0012014-08-11T00:00:002017-01-05T00:00:00Blood Flow Velocity12.111255249098964e-0012008-03-01T00:00:002008-03-01T00:00:00Prospective Studies242.100341766021291e-0011987-05-01T00:00:002024-03-22T00:00:00Sarcina12.089244733906596e-0012023-11-17T00:00:002023-11-17T00:00:00Serum32.074843971670667e-0012008-01-09T00:00:002017-11-21T00:00:00Heterocyclic Compounds, 4 or More Rings22.067516785760167e-0012015-11-17T00:00:002016-07-20T00:00:00Hepatitis B Surface Antigens32.022688355710821e-0011988-03-01T00:00:002022-11-11T00:00:00Cholangitis, Sclerosing22.004034704759254e-0012011-11-30T00:00:002019-01-11T00:00:00Adenoma21.997709552957570e-0011987-05-01T00:00:002012-05-01T00:00:00Young Adult201.939375346897948e-0012010-04-08T00:00:002021-06-09T00:00:00Drug Combinations41.931863013392234e-0012014-04-11T00:00:002018-04-17T00:00:00Stomach21.929065416632750e-0012005-11-01T00:00:002023-11-17T00:00:00Microspheres21.925691807853758e-0011997-10-01T00:00:002004-03-01T00:00:00Health Services Research11.924215089255518e-0012010-05-23T00:00:002010-05-23T00:00:00RNA-Dependent RNA Polymerase41.895919688053051e-0012014-04-11T00:00:002016-12-05T00:00:00Gastrointestinal Hemorrhage11.893521402333229e-0012010-06-24T00:00:002010-06-24T00:00:00Intercellular Signaling Peptides and Proteins21.875461831741935e-0012017-11-21T00:00:002021-10-26T00:00:00Sterols21.866954644801748e-0012001-07-01T00:00:002004-04-08T00:00:00Aged, 80 and over171.858686122752975e-0012008-01-15T00:00:002023-11-17T00:00:00Proteomics21.827745244759559e-0012008-01-15T00:00:002024-11-29T00:00:00HIV Infections81.817813648424212e-0012005-03-24T00:00:002014-10-14T00:00:00Diffusion of Innovation11.816622444389533e-0012007-01-29T00:00:002007-01-29T00:00:00Organophosphonates21.792471146954577e-0012012-12-10T00:00:002014-08-11T00:00:00Chemical and Drug Induced Liver Injury21.779880836665384e-0012006-01-01T00:00:002021-11-09T00:00:00Chemokine CXCL1021.737580635104380e-0012011-01-01T00:00:002014-06-06T00:00:00Chitinase-3-Like Protein 141.725938983897822e-0012006-04-01T00:00:002013-06-05T00:00:00Kupffer Cells11.717481123284527e-0012021-10-26T00:00:002021-10-26T00:00:00Mass Screening21.705702183519533e-0011996-07-01T00:00:002013-11-01T00:00:00Bile Ducts21.690462014840504e-0011993-05-01T00:00:002011-11-30T00:00:00Mitochondria, Liver11.688926146827677e-0012021-11-09T00:00:002021-11-09T00:00:00Autocrine Communication11.677341321478718e-0012021-10-26T00:00:002021-10-26T00:00:00Bile Duct Diseases11.677262759848906e-0012001-07-01T00:00:002001-07-01T00:00:00Hepatic Stellate Cells21.676112932769459e-0012010-10-26T00:00:002012-12-01T00:00:00Interferon Type I11.665801804095750e-0012005-08-01T00:00:002005-08-01T00:00:00Acetyltransferases11.661794327769452e-0012021-11-09T00:00:002021-11-09T00:00:00Collagen51.648643562793258e-0012018-01-25T00:00:002022-02-07T00:00:00Weight Loss11.647547786365616e-0012012-08-08T00:00:002012-08-08T00:00:00Registries21.637081353179978e-0012016-02-24T00:00:002016-07-25T00:00:00Cattle101.616270693044106e-0011990-06-01T00:00:002004-03-01T00:00:00Quality Assurance, Health Care11.611100877186863e-0012010-05-23T00:00:002010-05-23T00:00:00Quantitative Trait Loci21.608719160653772e-0012004-04-01T00:00:002010-06-01T00:00:00Quality Indicators, Health Care11.605771396594402e-0012010-05-23T00:00:002010-05-23T00:00:00Ascites31.604175958250441e-0012007-02-17T00:00:002018-03-11T00:00:00Randomized Controlled Trials as Topic91.602964599226048e-0012005-02-01T00:00:002021-12-01T00:00:00Hemorrhage11.595091249699335e-0012012-08-23T00:00:002012-08-23T00:00:00Chemoembolization, Therapeutic11.579922891302836e-0012021-02-12T00:00:002021-02-12T00:00:00Risk Assessment91.579303572821486e-0012005-02-01T00:00:002024-11-29T00:00:00Coinfection31.574144467109996e-0012012-03-15T00:00:002014-10-14T00:00:00Hepatitis, Alcoholic11.567217153782811e-0012021-12-07T00:00:002021-12-07T00:00:00Paracrine Communication11.562882537414240e-0012021-10-26T00:00:002021-10-26T00:00:00Cell-Derived Microparticles21.532383710556303e-0012010-10-26T00:00:002012-04-24T00:00:00Tooth Extraction11.517306462620820e-0012021-02-12T00:00:002021-02-12T00:00:00Lectins41.497456160472102e-0012006-04-01T00:00:002013-06-05T00:00:00Adipokines41.492016367931345e-0012006-04-01T00:00:002013-06-05T00:00:00Focal Nodular Hyperplasia21.435678514009573e-0012004-01-01T00:00:002012-05-01T00:00:00Antibodies, Monoclonal, Humanized41.431144030374875e-0012017-12-26T00:00:002019-05-28T00:00:00Pyridines31.396614462871449e-0012017-12-26T00:00:002022-09-09T00:00:00Radiofrequency Ablation11.395376830665287e-0012021-02-12T00:00:002021-02-12T00:00:00Endoscopy, Digestive System11.394600511599557e-0012021-02-12T00:00:002021-02-12T00:00:00Desmosine11.392359731248288e-0011997-12-01T00:00:001997-12-01T00:00:00Clinical Trials, Phase III as Topic31.391187507020645e-0012016-02-22T00:00:002019-08-19T00:00:00MAP Kinase Kinase Kinase 511.383455568006086e-0012017-12-26T00:00:002017-12-26T00:00:00Cognition Disorders11.368831719065872e-0012011-10-23T00:00:002011-10-23T00:00:00Recurrence41.367799388580268e-0011991-04-01T00:00:002014-09-28T00:00:00Magnetic Resonance Imaging81.364022418767606e-0012004-06-01T00:00:002018-10-04T00:00:00Amino Acid Oxidoreductases11.362874525360110e-0012018-07-07T00:00:002018-07-07T00:00:00Cell Transplantation11.356950151911114e-0011999-11-01T00:00:001999-11-01T00:00:00Neutropenia31.343025942583850e-0012004-03-01T00:00:002011-05-20T00:00:00Aging, Premature11.332280668966217e-0012018-01-25T00:00:002018-01-25T00:00:00Adenine21.316457996098898e-0012012-12-10T00:00:002014-08-11T00:00:00Radiography31.314859698829680e-0012005-11-01T00:00:002019-04-01T00:00:00Hepatitis B Virus, Woodchuck11.312251678368544e-0012017-01-05T00:00:002017-01-05T00:00:00Marmota11.306279378352203e-0012017-01-05T00:00:002017-01-05T00:00:00Procollagen31.292198502298065e-0011997-12-01T00:00:002006-04-01T00:00:00Practice Guidelines as Topic21.289335250886250e-0012012-05-01T00:00:002013-11-01T00:00:00Anesthesia11.284091764651761e-0012008-03-01T00:00:002008-03-01T00:00:00Reagent Kits, Diagnostic21.282910594870090e-0012015-05-28T00:00:002015-10-13T00:00:00Liver Diseases, Alcoholic21.281009543163720e-0012016-01-07T00:00:002016-07-01T00:00:00Decision Support Techniques21.278276039430928e-0012017-05-01T00:00:002017-11-21T00:00:00Crohn Disease31.249480778831303e-0011989-07-01T00:00:001999-05-01T00:00:00Time Factors151.245960426338665e-0011990-11-01T00:00:002018-07-07T00:00:00Solutions31.228514945972779e-0011997-10-01T00:00:002005-11-01T00:00:00Receptors, Concanavalin A21.217660972700932e-0011990-04-01T00:00:001993-04-01T00:00:00Polymorphism, Genetic41.214602547591983e-0012004-04-01T00:00:002012-02-22T00:00:00Age Factors61.203024953190261e-0012007-09-24T00:00:002016-02-22T00:00:00Viscosity41.193270822574098e-0011997-10-01T00:00:002009-08-11T00:00:00Forecasting21.192072339275412e-0012008-09-01T00:00:002019-07-01T00:00:00Epoetin Alfa31.191857610513987e-0012004-03-01T00:00:002004-12-01T00:00:00Sigmoidoscopy11.181499020054255e-0011996-07-01T00:00:001996-07-01T00:00:00Acute-On-Chronic Liver Failure11.170603977734816e-0012016-04-01T00:00:002016-04-01T00:00:00Enzyme Inhibitors31.153355285811647e-0011997-04-01T00:00:002018-07-07T00:00:00Concanavalin A21.135255705858517e-0011994-03-01T00:00:001996-06-01T00:00:00Lipoproteins, VLDL11.120598475241185e-0012016-02-24T00:00:002016-02-24T00:00:00Contraindications21.120366336667958e-0012004-09-01T00:00:002008-03-08T00:00:00Ammonia11.115276183566301e-0012016-04-01T00:00:002016-04-01T00:00:00Black or African American61.110612090598820e-0012006-08-01T00:00:002015-12-18T00:00:00Patient Care Management21.086370962545863e-0012007-11-01T00:00:002007-11-01T00:00:00RNA31.084173628801757e-0011998-10-09T00:00:002022-11-11T00:00:00Carbon Tetrachloride21.083024810542267e-0011999-11-01T00:00:002008-03-01T00:00:00Cholesterol, Dietary21.082845620160305e-0011993-04-01T00:00:002005-12-27T00:00:00Boston51.082073895115161e-0011996-07-01T00:00:002014-06-04T00:00:00Calcium Phosphates11.077094528732741e-0011995-11-01T00:00:001995-11-01T00:00:00Serine Proteinase Inhibitors21.071505520971277e-0012010-04-08T00:00:002013-02-11T00:00:00Data Interpretation, Statistical21.071327444398599e-0012007-09-24T00:00:002018-08-15T00:00:00Aspirin21.069401873132697e-0012016-01-07T00:00:002016-07-01T00:00:00Adolescent161.058321375921840e-0012006-08-01T00:00:002021-06-09T00:00:00alpha-Fetoproteins31.054107000343648e-0012008-01-15T00:00:002011-04-01T00:00:00Animals331.047496174433159e-0011990-06-01T00:00:002017-01-05T00:00:00Diagnostic Imaging21.045366155866384e-0012004-06-01T00:00:002008-05-01T00:00:00Biomarkers, Tumor31.035962673255848e-0012008-01-15T00:00:002011-04-01T00:00:00Reproducibility of Results91.031072920133306e-0012000-11-01T00:00:002019-08-19T00:00:00New Zealand11.017743576465099e-0012014-09-28T00:00:002014-09-28T00:00:00Liposomes11.009185720414639e-0011997-10-01T00:00:001997-10-01T00:00:00Ultrasonography, Doppler21.005207088495644e-0012004-06-01T00:00:002007-10-01T00:00:00Aminopeptidases11.000749558158171e-0011994-03-01T00:00:001994-03-01T00:00:00Blood Chemical Analysis11.000443756423864e-0012015-05-28T00:00:002015-05-28T00:00:00Amino Acids29.911558274389638e-0021990-06-01T00:00:001997-12-01T00:00:00Swine79.880494599210725e-0021996-12-01T00:00:002009-08-11T00:00:00Alprostadil19.855648494214840e-0021993-04-01T00:00:001993-04-01T00:00:00Outcome Assessment, Health Care29.818701978064992e-0022018-08-15T00:00:002018-08-23T00:00:00Follow-Up Studies129.804416646113541e-0021988-06-01T00:00:002018-08-23T00:00:00Transforming Growth Factor beta39.787180593921457e-0022003-01-01T00:00:002012-12-01T00:00:00Pyrophosphatases29.781442923891848e-0022010-06-12T00:00:002011-05-20T00:00:00Hydrogen-Ion Concentration59.780230474866825e-0021989-12-01T00:00:002009-08-11T00:00:00Bilirubin39.743626021195058e-0021990-06-01T00:00:002009-06-01T00:00:00Monocytes29.740639615583732e-0022004-07-01T00:00:002021-10-26T00:00:00Cryptosporidiosis19.713206124115295e-0021993-05-01T00:00:001993-05-01T00:00:00Models, Economic19.695264565403372e-0022017-05-01T00:00:002017-05-01T00:00:00Waiting Lists29.666456501141771e-0022014-09-28T00:00:002017-05-01T00:00:00Quality-Adjusted Life Years29.642381789172520e-0022015-08-25T00:00:002017-05-01T00:00:00Lamivudine19.602809116849778e-0022014-08-11T00:00:002014-08-11T00:00:00Polymorphism, Single Nucleotide59.485583081819318e-0022010-04-24T00:00:002012-07-01T00:00:00Liver Abscess, Amebic19.437131381934523e-0022012-05-01T00:00:002012-05-01T00:00:00Liver Abscess, Pyogenic19.434533482512064e-0022012-05-01T00:00:002012-05-01T00:00:00alpha-Macroglobulins29.330951390932679e-0022008-01-09T00:00:002009-06-01T00:00:00Echinococcosis19.269747136500650e-0022012-05-01T00:00:002012-05-01T00:00:00Intention to Treat Analysis19.234589426964468e-0022013-10-12T00:00:002013-10-12T00:00:00Maintenance Chemotherapy19.171947804561893e-0022013-10-12T00:00:002013-10-12T00:00:00Interferon-gamma49.118846168855976e-0022004-08-01T00:00:002012-12-01T00:00:00Cholangitis19.088902065843724e-0021993-05-01T00:00:001993-05-01T00:00:00Muscle Contraction19.067354467439073e-0021997-04-01T00:00:001997-04-01T00:00:00Reference Values19.045835759739535e-0022019-03-15T00:00:002019-03-15T00:00:00Professional Practice18.997190788640988e-0022014-02-01T00:00:002014-02-01T00:00:00Tolvaptan18.989642153079773e-0022011-10-23T00:00:002011-10-23T00:00:00Receptors, Natural Killer Cell18.923205854503825e-0022011-08-24T00:00:002011-08-24T00:00:00Europe28.921514007381191e-0022014-09-28T00:00:002018-07-07T00:00:00Quality of Life68.835714293162184e-0022004-05-01T00:00:002015-03-18T00:00:00Nucleotidyltransferases18.833106641196976e-0022014-04-11T00:00:002014-04-11T00:00:00Scattering, Radiation38.822402862821410e-0021995-09-01T00:00:001999-03-01T00:00:00Centers for Disease Control and Prevention, U.S.18.719223614729567e-0022013-11-01T00:00:002013-11-01T00:00:00Thrombopoiesis18.673140900262776e-0022013-03-04T00:00:002013-03-04T00:00:00Prevalence68.656175507409403e-0022005-04-01T00:00:002021-06-09T00:00:00Image Processing, Computer-Assisted38.649226750883482e-0022000-11-01T00:00:002021-12-01T00:00:00Elasticity38.641282910138567e-0022005-05-01T00:00:002009-08-11T00:00:00Cholestasis18.514212333148463e-0022014-10-14T00:00:002014-10-14T00:00:00White People58.496081595089025e-0022006-08-01T00:00:002011-10-23T00:00:00Hemoglobins58.450396818331402e-0022004-05-01T00:00:002013-02-11T00:00:00Sex Factors38.439896602129493e-0022009-06-01T00:00:002016-02-22T00:00:00Calcium-Binding Proteins18.432813985276870e-0021995-11-01T00:00:001995-11-01T00:00:00Clofazimine18.422079142500030e-0021991-04-01T00:00:001991-04-01T00:00:00Inositol18.320799110518094e-0022011-10-23T00:00:002011-10-23T00:00:00Leukopenia18.294497788737247e-0022011-05-20T00:00:002011-05-20T00:00:00Induction Chemotherapy18.290185628833414e-0022013-10-12T00:00:002013-10-12T00:00:00Drug Users18.130848903311738e-0022012-03-15T00:00:002012-03-15T00:00:00Multivariate Analysis78.129719056977909e-0022006-10-01T00:00:002016-04-01T00:00:00Macromolecular Substances28.101998733712190e-0021999-03-01T00:00:002005-11-01T00:00:00Cross-Sectional Studies78.087942129427134e-0022007-01-24T00:00:002024-03-22T00:00:00Postoperative Care18.076967789501575e-0022017-05-01T00:00:002017-05-01T00:00:00Extracellular Matrix38.064807096792614e-0022001-02-01T00:00:002003-12-01T00:00:00Software18.014393447994393e-0022024-09-06T00:00:002024-09-06T00:00:00Cerebrovascular Disorders17.961634507951358e-0022017-04-26T00:00:002017-04-26T00:00:00Antigens, Neoplasm37.815932354626720e-0021985-10-01T00:00:002006-07-01T00:00:00Lipase17.808726425056563e-0022012-04-29T00:00:002012-04-29T00:00:00Injections, Subcutaneous37.782583067564239e-0022007-11-01T00:00:002018-10-04T00:00:00Withholding Treatment17.693579239278836e-0022014-08-11T00:00:002014-08-11T00:00:00Biophysical Phenomena37.690881224329753e-0021997-10-01T00:00:002002-09-01T00:00:00AIDS-Related Opportunistic Infections17.680019209355950e-0021993-05-01T00:00:001993-05-01T00:00:00Phytotherapy17.677463197845344e-0022011-11-04T00:00:002011-11-04T00:00:00Clinical Trials, Phase II as Topic37.656366759484114e-0022007-03-01T00:00:002021-12-01T00:00:00Choline17.646982522198446e-0022011-10-23T00:00:002011-10-23T00:00:00Reverse Transcriptase Inhibitors17.629432530063940e-0022012-12-10T00:00:002012-12-10T00:00:00Polytetrafluoroethylene17.576182270079765e-0022010-06-24T00:00:002010-06-24T00:00:00Anemia, Hemolytic17.556638407159715e-0022010-06-12T00:00:002010-06-12T00:00:00Tertiary Care Centers17.553203249213218e-0022015-05-25T00:00:002015-05-25T00:00:00Creatine17.511317361933745e-0022011-10-23T00:00:002011-10-23T00:00:00Peptide Fragments57.503970935827259e-0021997-05-15T00:00:002006-04-01T00:00:00Aspartic Acid17.486399791565905e-0022011-10-23T00:00:002011-10-23T00:00:00Biophysics37.479193147149182e-0021997-10-01T00:00:002002-09-01T00:00:00Colon37.469750296706114e-0021986-06-01T00:00:002005-04-01T00:00:00Physicians, Primary Care17.469159008281454e-0022016-02-23T00:00:002016-02-23T00:00:00Hepatitis C Antibodies17.350923631954198e-0022009-04-30T00:00:002009-04-30T00:00:00gamma-Glutamyltransferase17.338638691134253e-0022009-06-01T00:00:002009-06-01T00:00:00Killer Cells, Natural27.306481849430987e-0022004-08-01T00:00:002011-08-24T00:00:00Molecular Weight27.232122657577043e-0021994-03-01T00:00:002005-11-01T00:00:00Uncertainty17.225962176258412e-0022013-11-07T00:00:002013-11-07T00:00:00Patient Admission17.078783695781384e-0022016-04-01T00:00:002016-04-01T00:00:00Consensus Statements as Topic16.967255988193211e-0022010-07-01T00:00:002010-07-01T00:00:00Nitric Oxide16.952794662749927e-0021997-04-01T00:00:001997-04-01T00:00:00Cystatins16.906921656718040e-0022008-01-15T00:00:002008-01-15T00:00:00Algorithms46.906513985830107e-0022006-04-01T00:00:002024-09-06T00:00:00Head16.890072024910787e-0022014-06-04T00:00:002014-06-04T00:00:00Immunologic Factors16.876430152994853e-0022017-05-23T00:00:002017-05-23T00:00:00Intestinal Absorption26.859452718585729e-0021986-06-01T00:00:002004-04-08T00:00:00Area Under Curve46.793243705847311e-0022006-10-01T00:00:002015-10-13T00:00:00Pentanoic Acids16.762585411105916e-0022007-08-01T00:00:002007-08-01T00:00:00Neurokinin-1 Receptor Antagonists16.731944490469845e-0022008-03-01T00:00:002008-03-01T00:00:00Publishing16.668124376071365e-0022015-01-01T00:00:002015-01-01T00:00:00Hyperlipidemias16.644470627041590e-0022012-08-08T00:00:002012-08-08T00:00:00Fluorescent Dyes46.629910862861085e-0021990-06-01T00:00:001999-03-01T00:00:00Splenic Artery16.610543228315866e-0022007-10-01T00:00:002007-10-01T00:00:00Preoperative Care16.597366675948731e-0022017-05-01T00:00:002017-05-01T00:00:00Surgical Procedures, Operative16.587097983652125e-0022019-03-15T00:00:002019-03-15T00:00:00Mucus16.580217227853590e-0022009-08-11T00:00:002009-08-11T00:00:00Risk16.577130997386219e-0022019-04-01T00:00:002019-04-01T00:00:00Triglycerides16.568973201039129e-0022015-04-27T00:00:002015-04-27T00:00:00Patient Compliance36.529782118301725e-0022004-09-01T00:00:002013-04-01T00:00:00Hypereosinophilic Syndrome16.503354756982947e-0022008-01-01T00:00:002008-01-01T00:00:00Caspase Inhibitors16.473392735729580e-0022007-08-01T00:00:002007-08-01T00:00:00Tomography, X-Ray Computed46.465116988353083e-0022004-06-01T00:00:002014-06-04T00:00:00Intestinal Polyps16.425719775525980e-0021987-05-01T00:00:001987-05-01T00:00:00Acute Disease36.416760669191746e-0022004-08-01T00:00:002006-05-01T00:00:00Phase Transition16.404866675934441e-0022007-04-03T00:00:002007-04-03T00:00:00Immunohistochemistry56.303074452300080e-0021997-04-01T00:00:002012-12-10T00:00:00Cysts16.277340665561600e-0022012-05-01T00:00:002012-05-01T00:00:00Pharmacogenetics16.243495660704225e-0022011-01-01T00:00:002011-01-01T00:00:00Treatment Failure46.238025156862033e-0022010-04-08T00:00:002016-12-05T00:00:00Colonic Diseases, Functional16.201716706529241e-0021986-06-01T00:00:001986-06-01T00:00:00Dietary Supplements26.177162962347763e-0022008-01-09T00:00:002011-11-30T00:00:00Sodium16.176991146649266e-0022011-10-23T00:00:002011-10-23T00:00:00Spectrometry, Fluorescence26.171679976329270e-0021990-06-01T00:00:002004-03-01T00:00:00Diffusion26.148855004211142e-0021997-10-01T00:00:001999-03-01T00:00:00Cystatin C16.144773153166193e-0022008-01-15T00:00:002008-01-15T00:00:00Risk Factors96.112933621332198e-0021999-05-01T00:00:002022-03-01T00:00:00Microscopy, Fluorescence36.109361215451519e-0021995-09-01T00:00:002009-08-11T00:00:00Clinical Trials as Topic46.105150672093622e-0022006-09-18T00:00:002012-05-01T00:00:00Oligodeoxyribonucleotides16.103260584317233e-0022007-11-01T00:00:002007-11-01T00:00:00Renal Circulation16.083569761824960e-0022007-02-17T00:00:002007-02-17T00:00:00Phenylurea Compounds16.073818041076643e-0022009-12-01T00:00:002009-12-01T00:00:00Peptides36.023704014265205e-0021990-06-01T00:00:001999-04-01T00:00:00Hepatic Artery16.006106149857952e-0022007-10-01T00:00:002007-10-01T00:00:00Prednisone25.968177252838898e-0022006-01-01T00:00:002008-01-01T00:00:00Serologic Tests15.959335979650851e-0022008-05-01T00:00:002008-05-01T00:00:00Anti-Inflammatory Agents, Non-Steroidal15.937841598466589e-0022016-01-07T00:00:002016-01-07T00:00:00Ubiquitin15.921769246945703e-0022011-04-01T00:00:002011-04-01T00:00:00Benzopyrans25.908891289756189e-0022015-11-17T00:00:002016-07-20T00:00:00Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization15.902752544709614e-0022008-01-15T00:00:002008-01-15T00:00:00Thrombopoietin15.899073940622185e-0022008-03-31T00:00:002008-03-31T00:00:00Renin-Angiotensin System15.896656272385823e-0022010-07-01T00:00:002010-07-01T00:00:00Vascular Resistance25.817776547351200e-0021992-03-01T00:00:002007-10-01T00:00:00Helicobacter pylori15.795013731326347e-0022009-08-11T00:00:002009-08-11T00:00:00Socioeconomic Factors15.698444395841610e-0022019-07-01T00:00:002019-07-01T00:00:00Combined Modality Therapy15.694027281965918e-0022017-05-01T00:00:002017-05-01T00:00:00Phlebitis15.691861616735346e-0022005-04-01T00:00:002005-04-01T00:00:00Carbohydrate Metabolism15.645574485863292e-0021986-06-01T00:00:001986-06-01T00:00:00Enzyme-Linked Immunosorbent Assay35.640367898499839e-0021996-06-01T00:00:002024-11-29T00:00:00Sciuridae25.622870055142223e-0021993-04-01T00:00:001997-04-01T00:00:00Protein Conformation25.606479711392364e-0021999-03-01T00:00:002005-11-01T00:00:00Fibrinolysis25.602526387604856e-0021989-12-01T00:00:002001-02-01T00:00:00Microscopy, Atomic Force15.596945737919293e-0022005-11-01T00:00:002005-11-01T00:00:00Insulin Resistance25.575265263591819e-0022007-01-01T00:00:002010-11-09T00:00:00Transaminases15.570847045590626e-0022005-11-28T00:00:002005-11-28T00:00:00Electrophoresis, Polyacrylamide Gel35.536542356255090e-0021990-06-01T00:00:001993-04-01T00:00:00Docosahexaenoic Acids15.483408582505671e-0022011-11-30T00:00:002011-11-30T00:00:00T-Lymphocytes, Cytotoxic35.469339768061934e-0021993-12-01T00:00:001998-02-01T00:00:00Patient Safety15.467739055365255e-0022016-02-22T00:00:002016-02-22T00:00:00Diagnosis, Differential45.412639808019872e-0022007-10-01T00:00:002021-12-01T00:00:00MicroRNAs25.396114403242656e-0022010-10-07T00:00:002011-04-01T00:00:00Estrogen Receptor alpha25.391362910472260e-0022004-07-01T00:00:002005-12-27T00:00:00Ileal Neoplasms15.389082363158810e-0021984-05-01T00:00:001984-05-01T00:00:00Cardiac Output15.370120272167304e-0022007-02-17T00:00:002007-02-17T00:00:00Cholesterol 7-alpha-Hydroxylase15.361938055587962e-0022004-04-01T00:00:002004-04-01T00:00:00Molecular Conformation15.357289758102254e-0022005-11-01T00:00:002005-11-01T00:00:00Blood Coagulation Disorders15.345466416175932e-0022007-11-01T00:00:002007-11-01T00:00:00Elective Surgical Procedures15.335781705316488e-0022012-08-23T00:00:002012-08-23T00:00:00Proteasome Endopeptidase Complex15.330030614173756e-0022011-04-01T00:00:002011-04-01T00:00:00Antioxidants15.321855258904849e-0022012-07-18T00:00:002012-07-18T00:00:00RNA, Messenger55.309914855397856e-0021995-08-15T00:00:002006-07-01T00:00:00Proto-Oncogene Proteins c-sis25.298655783027465e-0022003-01-01T00:00:002021-10-26T00:00:00Integrin alpha1beta115.281289443153994e-0022003-12-01T00:00:002003-12-01T00:00:00Integrin alpha2beta115.261838738957508e-0022003-12-01T00:00:002003-12-01T00:00:00Growth Substances25.254041121321366e-0022003-01-01T00:00:002003-12-01T00:00:00CD8-Positive T-Lymphocytes35.234462400637176e-0022010-10-26T00:00:002012-12-01T00:00:00Substance Abuse, Intravenous25.231603574947832e-0022005-04-01T00:00:002006-04-01T00:00:00Protective Agents15.199023047052729e-0022005-04-13T00:00:002005-04-13T00:00:00Iron Overload15.182128533820434e-0022006-06-01T00:00:002006-06-01T00:00:00Neurotransmitter Agents15.157819887486106e-0022008-03-01T00:00:002008-03-01T00:00:00Blotting, Western45.150358620231087e-0021993-04-01T00:00:002006-07-01T00:00:00Periodicals as Topic15.133082848616120e-0022015-01-01T00:00:002015-01-01T00:00:00Epigenesis, Genetic15.104987395354346e-0022018-01-25T00:00:002018-01-25T00:00:00Interferon-beta15.103564505902859e-0022006-01-01T00:00:002006-01-01T00:00:00Anilino Naphthalenesulfonates25.101303350088943e-0021990-06-01T00:00:001995-11-01T00:00:00Drug Implants15.097548801132776e-0022004-07-01T00:00:002004-07-01T00:00:00Endoscopy, Gastrointestinal15.086291520823627e-0022010-09-01T00:00:002010-09-01T00:00:00Magnetic Resonance Spectroscopy25.079484690443778e-0022002-09-01T00:00:002011-10-23T00:00:00Risk Reduction Behavior15.073447283225808e-0022010-07-01T00:00:002010-07-01T00:00:00Clostridium15.044906799852940e-0022023-11-17T00:00:002023-11-17T00:00:00Pilot Projects25.012146067047281e-0022011-11-30T00:00:002014-09-28T00:00:00Renal Insufficiency, Chronic15.007047498555336e-0022018-04-17T00:00:002018-04-17T00:00:00Mucin-124.957957247942438e-0022004-04-08T00:00:002006-07-01T00:00:00Microscopy, Electron24.955411205088549e-0021995-09-01T00:00:001997-10-01T00:00:00DNA Methylation14.926050319150455e-0022018-01-25T00:00:002018-01-25T00:00:00Gels24.901631411147658e-0021999-03-01T00:00:002007-04-03T00:00:00Bradycardia14.856423814030558e-0021985-03-01T00:00:001985-03-01T00:00:00Viral Core Proteins24.850123873362096e-0021993-12-01T00:00:002012-12-01T00:00:00Ultrasonography24.786795350683883e-0022012-05-01T00:00:002015-10-13T00:00:00Alkaline Phosphatase24.761572825031425e-0022011-11-30T00:00:002019-01-11T00:00:00Membrane Proteins44.753052116261880e-0021995-08-15T00:00:002012-04-29T00:00:00Glycosylation14.729002405618711e-0022005-11-01T00:00:002005-11-01T00:00:00Fluoresceins24.711320695744084e-0021995-09-01T00:00:002009-08-11T00:00:00Mental Disorders24.706944057433107e-0022007-02-17T00:00:002017-04-26T00:00:00Body Weight24.685861653061473e-0022007-10-01T00:00:002010-11-09T00:00:00Macrophages14.650869022156559e-0022017-11-21T00:00:002017-11-21T00:00:00Amino Acid Sequence94.629087269469324e-0021990-11-01T00:00:001999-04-01T00:00:00United States Food and Drug Administration14.628570719086303e-0022011-01-01T00:00:002011-01-01T00:00:00Infusions, Intravenous14.618242370540127e-0022007-02-17T00:00:002007-02-17T00:00:00Cholesterol, LDL14.608149525996869e-0022012-02-22T00:00:002012-02-22T00:00:00Matrix Metalloproteinases24.607386375326823e-0022001-02-01T00:00:002003-12-01T00:00:00Sphingomyelins14.594404186154364e-0022002-09-01T00:00:002002-09-01T00:00:00Logistic Models44.584944759185154e-0022006-10-01T00:00:002013-08-04T00:00:00Cytokines44.565801507391101e-0021995-11-01T00:00:002007-11-01T00:00:00Evaluation Studies as Topic14.557157152306599e-0022004-06-01T00:00:002004-06-01T00:00:00Light24.544911536538600e-0021997-10-01T00:00:001999-03-01T00:00:00Serum Albumin14.502380998355145e-0022005-04-25T00:00:002005-04-25T00:00:00Viral Proteases24.481640682979327e-0022004-07-01T00:00:002016-06-11T00:00:00Antigens, CD114.477924489872204e-0022004-08-01T00:00:002004-08-01T00:00:00Nucleoside-Triphosphatase24.455759198257822e-0022004-07-01T00:00:002016-06-11T00:00:00Health Surveys14.454759739181016e-0022011-10-23T00:00:002011-10-23T00:00:00Actins24.434363210678573e-0022018-08-23T00:00:002019-05-28T00:00:00Mice, Inbred Strains14.400368396196440e-0022004-04-01T00:00:002004-04-01T00:00:00Energy Intake14.396639251534854e-0021989-07-01T00:00:001989-07-01T00:00:00Abdominal Pain24.393750877402609e-0022004-01-01T00:00:002005-04-01T00:00:00Immunity, Innate14.363878237696652e-0022014-06-06T00:00:002014-06-06T00:00:00Genetic Predisposition to Disease44.351461816773293e-0022004-01-01T00:00:002010-06-01T00:00:00Electroencephalography14.309739529244603e-0022017-04-26T00:00:002017-04-26T00:00:00Myocardial Infarction14.305072026560387e-0022022-03-01T00:00:002022-03-01T00:00:00Inosine Triphosphatase24.301926982952706e-0022010-06-12T00:00:002011-05-20T00:00:00Analgesics14.218549628890578e-0022008-03-01T00:00:002008-03-01T00:00:00Neoplasm Staging14.196785911453149e-0022015-12-30T00:00:002015-12-30T00:00:00Gene Expression34.195374383128220e-0022004-07-01T00:00:002012-12-01T00:00:00Protein Kinase Inhibitors14.192724426771628e-0022017-12-26T00:00:002017-12-26T00:00:00Georgia (Republic)14.185598933761789e-0022020-08-22T00:00:002020-08-22T00:00:00HIV14.179272552926371e-0022007-10-18T00:00:002007-10-18T00:00:00Lipoproteins24.156927839698935e-0022004-04-08T00:00:002021-12-07T00:00:00Chromosome Mapping24.142215824617522e-0022004-04-01T00:00:002010-06-01T00:00:00Estradiol24.071471749608982e-0022004-07-01T00:00:002005-12-27T00:00:00Odds Ratio14.063640609952512e-0022012-07-01T00:00:002012-07-01T00:00:00Collagen Type IV14.063045625038679e-0022001-02-01T00:00:002001-02-01T00:00:00In Vitro Techniques24.036179790556067e-0021995-11-01T00:00:001997-10-01T00:00:00CD4-Positive T-Lymphocytes34.026671380818633e-0022004-07-01T00:00:002012-04-24T00:00:00Intestinal Obstruction13.998143985984446e-0021984-05-01T00:00:001984-05-01T00:00:00Drug Synergism13.963942910248954e-0022004-05-01T00:00:002004-05-01T00:00:00Long-Term Care13.959771728460179e-0022005-02-01T00:00:002005-02-01T00:00:00North America23.944448977664099e-0022007-01-24T00:00:002018-07-07T00:00:00Osmolar Concentration23.941564743199676e-0021994-03-01T00:00:002007-04-03T00:00:00Georgia13.941243825716229e-0022020-08-22T00:00:002020-08-22T00:00:00Apolipoproteins B13.939504819309773e-0022021-12-07T00:00:002021-12-07T00:00:00Adjuvants, Immunologic13.935327536247865e-0022006-01-01T00:00:002006-01-01T00:00:00Rats33.891583035698952e-0021999-11-01T00:00:002008-03-01T00:00:00Protein Binding33.840217629476803e-0021990-06-01T00:00:002005-11-01T00:00:00Inflammation23.832503029155296e-0022007-09-24T00:00:002012-04-24T00:00:00Venous Pressure13.812151781960473e-0022019-05-28T00:00:002019-05-28T00:00:00Laminin13.794153648699916e-0022001-02-01T00:00:002001-02-01T00:00:00Disease Models, Animal33.783542565631912e-0022004-04-01T00:00:002010-07-01T00:00:00Alanine13.735730580387608e-0022022-04-21T00:00:002022-04-21T00:00:00Catheter Ablation13.726515602874799e-0022012-06-07T00:00:002012-06-07T00:00:00Patient Selection23.670695239101439e-0022004-09-01T00:00:002018-03-11T00:00:00Blood Proteins13.656866295745338e-0022024-11-29T00:00:002024-11-29T00:00:00T-Lymphocytes, Regulatory13.632241365200941e-0022012-12-01T00:00:002012-12-01T00:00:00Plastic Surgery Procedures13.615186739402267e-0022012-06-07T00:00:002012-06-07T00:00:00Communicable Disease Control13.598666193050376e-0022005-04-01T00:00:002005-04-01T00:00:00Phospholipids13.590882577643734e-0022002-09-01T00:00:002002-09-01T00:00:00Body Mass Index33.576349619550283e-0022009-04-01T00:00:002015-04-27T00:00:00Network Meta-Analysis as Topic13.544766357131612e-0022018-08-15T00:00:002018-08-15T00:00:00Neuropsychological Tests13.540515360943538e-0022011-10-23T00:00:002011-10-23T00:00:00Static Electricity13.538240380676588e-0021999-03-01T00:00:001999-03-01T00:00:00Genetic Association Studies23.528038071125324e-0022012-02-22T00:00:002021-11-09T00:00:00Membrane Transport Proteins13.506343908876655e-0022004-04-08T00:00:002004-04-08T00:00:00Global Health13.482926161705585e-0022013-04-01T00:00:002013-04-01T00:00:00Rectal Neoplasms13.458193133134489e-0021987-05-01T00:00:001987-05-01T00:00:00DEAD-box RNA Helicases23.447578637818545e-0022004-07-01T00:00:002016-06-11T00:00:00Polyacrylamides13.442394276253795e-0021997-10-01T00:00:001997-10-01T00:00:00Nutrition Surveys23.427656781416788e-0022015-04-27T00:00:002016-01-07T00:00:00Angina, Unstable13.421056968589892e-0022022-03-01T00:00:002022-03-01T00:00:00Health Knowledge, Attitudes, Practice13.414507857882619e-0022013-04-01T00:00:002013-04-01T00:00:00Rats, Inbred Lew13.401998917277743e-0021999-11-01T00:00:001999-11-01T00:00:00Heart Failure13.359949227387960e-0022022-03-01T00:00:002022-03-01T00:00:00Survival Analysis23.336938383536005e-0022005-02-01T00:00:002012-06-07T00:00:00Diagnostic Techniques and Procedures13.334711663267190e-0022019-08-19T00:00:002019-08-19T00:00:00Bethanechol13.324609483531660e-0021997-04-01T00:00:001997-04-01T00:00:00Blood Platelets13.294789695987091e-0022008-03-31T00:00:002008-03-31T00:00:00Polystyrenes13.278806899712713e-0021997-10-01T00:00:001997-10-01T00:00:00Rheology23.254097209068683e-0022007-04-03T00:00:002009-08-11T00:00:00Muscle Tonus13.232981293167465e-0021997-04-01T00:00:001997-04-01T00:00:00Molecular Sequence Data83.227629991010280e-0021990-11-01T00:00:001999-04-01T00:00:00Acrylic Resins13.221655636442496e-0021997-10-01T00:00:001997-10-01T00:00:00Antiretroviral Therapy, Highly Active13.204021484550127e-0022005-03-24T00:00:002005-03-24T00:00:00Rats, Sprague-Dawley13.184059250524577e-0022008-03-01T00:00:002008-03-01T00:00:00Chromatography, High Pressure Liquid23.174570962932276e-0021990-06-01T00:00:001990-11-01T00:00:00Sigmoidoscopes13.172076940781298e-0021996-07-01T00:00:001996-07-01T00:00:00Ethnicity13.170121352920525e-0022012-07-01T00:00:002012-07-01T00:00:00Cholecystokinin13.168823315529704e-0021997-04-01T00:00:001997-04-01T00:00:00Cytotoxicity, Immunologic23.132229207130085e-0021993-12-01T00:00:001998-02-01T00:00:00Pronase13.132137994698458e-0021996-06-01T00:00:001996-06-01T00:00:00Sleep Apnea Syndromes13.129585787074424e-0021985-03-01T00:00:001985-03-01T00:00:00NG-Nitroarginine Methyl Ester13.115987582706922e-0021997-04-01T00:00:001997-04-01T00:00:00Albumins13.106607333247977e-0021999-11-01T00:00:001999-11-01T00:00:00Cell Transformation, Neoplastic13.106005904137923e-0022006-06-01T00:00:002006-06-01T00:00:00Extracellular Matrix Proteins13.077057359899801e-0022001-02-01T00:00:002001-02-01T00:00:00T-Lymphocyte Subsets13.076429828283316e-0022004-08-01T00:00:002004-08-01T00:00:00Exanthema23.062462501289420e-0022010-04-08T00:00:002011-09-15T00:00:00Serine Endopeptidases23.060683374755866e-0022004-07-01T00:00:002016-06-11T00:00:00Lipoprotein(a)13.029456695605262e-0022021-12-07T00:00:002021-12-07T00:00:00Receptors, Estrogen12.992566977691388e-0022004-07-01T00:00:002004-07-01T00:00:00In Situ Hybridization12.986795113246128e-0021999-11-01T00:00:001999-11-01T00:00:00Interleukin-1032.983478870665090e-0021995-11-01T00:00:002012-12-01T00:00:00Ampulla of Vater12.978667054488933e-0021996-12-01T00:00:001996-12-01T00:00:00Fatty Acids12.976986066726934e-0022004-04-08T00:00:002004-04-08T00:00:00Chemical Precipitation12.962696055589712e-0021995-11-01T00:00:001995-11-01T00:00:00Nephelometry and Turbidimetry12.959729126980835e-0021995-11-01T00:00:001995-11-01T00:00:00Epithelial Cells22.952835025184497e-0021998-10-09T00:00:002006-07-01T00:00:00Lipids22.949547423070024e-0022002-09-01T00:00:002004-04-01T00:00:00Acquired Immunodeficiency Syndrome12.946799206111708e-0022004-07-01T00:00:002004-07-01T00:00:00Egypt22.945488113127942e-0022004-11-01T00:00:002007-01-24T00:00:00Proteins12.920812454186164e-0021990-06-01T00:00:001990-06-01T00:00:00Energy Transfer12.907628337200360e-0021995-09-01T00:00:001995-09-01T00:00:00Genes, Viral12.898017618438300e-0022016-12-05T00:00:002016-12-05T00:00:00Species Specificity12.888231826758453e-0021999-11-01T00:00:001999-11-01T00:00:00Conserved Sequence12.884021161011621e-0021998-10-09T00:00:001998-10-09T00:00:00Endometriosis12.875065624121851e-0021984-05-01T00:00:001984-05-01T00:00:00Receptors, Lipoprotein12.853733783980085e-0021995-08-15T00:00:001995-08-15T00:00:00Exercise12.838939154682926e-0022012-08-08T00:00:002012-08-08T00:00:00Colonic Neoplasms12.819317779186942e-0021987-05-01T00:00:001987-05-01T00:00:00Delivery of Health Care12.799242942848144e-0022013-04-01T00:00:002013-04-01T00:00:00Physicians12.798423098487033e-0022013-04-01T00:00:002013-04-01T00:00:00Racial Groups12.783502629218812e-0022007-09-24T00:00:002007-09-24T00:00:00Estrogen Antagonists22.748607214179302e-0022004-07-01T00:00:002005-12-27T00:00:00Up-Regulation22.742186591474630e-0022010-10-26T00:00:002016-04-01T00:00:00Fiber Optic Technology12.718291332088033e-0021996-07-01T00:00:001996-07-01T00:00:00Lipid Metabolism22.714505921334259e-0021999-04-01T00:00:002004-07-01T00:00:00Phlebotomy12.703212294910269e-0022015-05-28T00:00:002015-05-28T00:00:00Linear Models22.685430050830622e-0022012-04-24T00:00:002016-02-24T00:00:00CD13 Antigens12.684396108577492e-0021994-03-01T00:00:001994-03-01T00:00:00Remission Induction22.672457949728067e-0021989-07-01T00:00:001991-04-01T00:00:00Binding, Competitive12.663949609118569e-0021995-11-01T00:00:001995-11-01T00:00:00Immunochemistry12.645944345217551e-0021994-03-01T00:00:001994-03-01T00:00:00Chromatography, Gel22.633580070408152e-0021990-06-01T00:00:001996-06-01T00:00:00Cysteine22.617203445576859e-0021995-08-15T00:00:001997-05-15T00:00:00Decision Trees12.616552907786631e-0022016-03-15T00:00:002016-03-15T00:00:00Datasets as Topic12.547788175537779e-0022018-01-25T00:00:002018-01-25T00:00:00Surveys and Questionnaires22.540292616881990e-0022011-10-23T00:00:002015-03-17T00:00:00Cognition12.530289198795149e-0022011-10-23T00:00:002011-10-23T00:00:00Transforming Growth Factor beta122.519333667755652e-0022003-01-01T00:00:002010-10-26T00:00:00Crystallography12.494822369403267e-0021993-05-01T00:00:001993-05-01T00:00:00Spleen12.480340646582195e-0021999-11-01T00:00:001999-11-01T00:00:00Particle Size12.475533982667281e-0021997-10-01T00:00:001997-10-01T00:00:00Probability12.475449932648796e-0022018-08-15T00:00:002018-08-15T00:00:00Depression12.473940956090427e-0022013-11-07T00:00:002013-11-07T00:00:00CpG Islands12.422214070619417e-0022018-01-25T00:00:002018-01-25T00:00:00Observational Studies as Topic12.412435750431259e-0022018-08-15T00:00:002018-08-15T00:00:00Collagen Type I, alpha 1 Chain12.401745644099098e-0022012-12-01T00:00:002012-12-01T00:00:00Transplantation, Heterologous12.386219438954495e-0021999-11-01T00:00:001999-11-01T00:00:00Headache22.360492823536391e-0022007-11-29T00:00:002013-03-15T00:00:00Mice82.347278808378810e-0022004-01-01T00:00:002010-06-01T00:00:00Matrix Metalloproteinase 112.340937067979352e-0022012-12-01T00:00:002012-12-01T00:00:00Phospholipases A2, Calcium-Independent12.330316128069929e-0022012-04-29T00:00:002012-04-29T00:00:00Portal System12.298912642068257e-0021992-03-01T00:00:001992-03-01T00:00:00Metaplasia12.282108017067466e-0021993-05-01T00:00:001993-05-01T00:00:00Blood Pressure22.269082715481989e-0021992-03-01T00:00:002007-02-17T00:00:00Receptors, KIR2DL312.258478490571773e-0022011-08-24T00:00:002011-08-24T00:00:00Hypertension12.255948634728510e-0022012-08-08T00:00:002012-08-08T00:00:00Imaging, Three-Dimensional12.255846125916211e-0022005-11-01T00:00:002005-11-01T00:00:00Receptors, KIR2DL112.252027353918940e-0022011-08-24T00:00:002011-08-24T00:00:00Receptors, KIR3DL112.244961156988125e-0022011-08-24T00:00:002011-08-24T00:00:00Puerto Rico12.208701536513792e-0022013-03-15T00:00:002013-03-15T00:00:00NK Cell Lectin-Like Receptor Subfamily C12.201507652016045e-0022011-08-24T00:00:002011-08-24T00:00:00Apoptosis12.200815847522645e-0022007-08-01T00:00:002007-08-01T00:00:00Catheterization12.181614596419368e-0021996-12-01T00:00:001996-12-01T00:00:00Water12.157339942521120e-0021997-10-01T00:00:001997-10-01T00:00:00Proportional Hazards Models22.145785566270589e-0022015-10-13T00:00:002016-04-01T00:00:00Reverse Transcriptase Polymerase Chain Reaction22.122372852724762e-0022004-04-08T00:00:002011-04-01T00:00:00Plasma12.111861784338672e-0022014-06-06T00:00:002014-06-06T00:00:00Receptor, Interferon alpha-beta12.098346525560249e-0022011-08-24T00:00:002011-08-24T00:00:00Organ Culture Techniques12.096461559327395e-0021993-04-01T00:00:001993-04-01T00:00:00Mass Spectrometry12.082282899103266e-0022018-04-26T00:00:002018-04-26T00:00:00Basigin12.064781866862141e-0022010-10-26T00:00:002010-10-26T00:00:00Prothrombin12.062349204703309e-0022011-04-01T00:00:002011-04-01T00:00:00Costs and Cost Analysis12.059794965956798e-0021996-07-01T00:00:001996-07-01T00:00:00Colonic Polyps12.054443350751436e-0021996-07-01T00:00:001996-07-01T00:00:00Immunologic Techniques12.036622135664021e-0021990-11-01T00:00:001990-11-01T00:00:00Multiple Sclerosis12.034449091704629e-0022006-01-01T00:00:002006-01-01T00:00:00Binding Sites12.030775105465427e-0021999-03-01T00:00:001999-03-01T00:00:00Acyltransferases12.026844090654952e-0022012-04-29T00:00:002012-04-29T00:00:00Half-Life12.026046381884690e-0022011-08-24T00:00:002011-08-24T00:00:00Sodium Dodecyl Sulfate12.003849756035293e-0021990-06-01T00:00:001990-06-01T00:00:00Chromatography, Ion Exchange12.000570795347831e-0021990-06-01T00:00:001990-06-01T00:00:00Microbial Sensitivity Tests12.000126340236020e-0022017-05-23T00:00:002017-05-23T00:00:00Editorial Policies11.999275192333884e-0022015-01-01T00:00:002015-01-01T00:00:00Chi-Square Distribution11.983435420017869e-0022016-04-01T00:00:002016-04-01T00:00:00Trypsin11.972165822669189e-0021990-11-01T00:00:001990-11-01T00:00:00Gastric Juice11.969446536054026e-0021989-12-01T00:00:001989-12-01T00:00:00Nausea11.967633914381728e-0022013-03-15T00:00:002013-03-15T00:00:00Viral Envelope Proteins11.957129433300226e-0021993-12-01T00:00:001993-12-01T00:00:00Signal Transduction21.949823475072982e-0022007-01-01T00:00:002010-10-07T00:00:00Obesity11.947286903167106e-0022012-08-08T00:00:002012-08-08T00:00:00Drug Evaluation11.943297431444096e-0021991-04-01T00:00:001991-04-01T00:00:00Urease11.936889051897362e-0022009-08-11T00:00:002009-08-11T00:00:00Research Design21.907262948711538e-0022011-11-04T00:00:002018-08-15T00:00:00Pregnancy Complications11.906282545664160e-0022004-01-01T00:00:002004-01-01T00:00:00Image-Guided Biopsy11.895593799326785e-0022015-10-13T00:00:002015-10-13T00:00:00Antigens, Tumor-Associated, Carbohydrate21.882432896955244e-0021985-10-01T00:00:001987-05-01T00:00:00Transcription Factors21.858861050625033e-0022004-04-01T00:00:002010-06-01T00:00:00Collagen Type I11.851769734479026e-0022012-12-01T00:00:002012-12-01T00:00:00Jurkat Cells11.849407974357089e-0022010-10-26T00:00:002010-10-26T00:00:00Virus Replication11.845093839226967e-0022017-01-05T00:00:002017-01-05T00:00:00Histocompatibility Antigens Class I11.833754046871160e-0021995-11-01T00:00:001995-11-01T00:00:00Fasting11.832493156074095e-0022015-04-27T00:00:002015-04-27T00:00:00Models, Molecular11.828803032918079e-0021999-03-01T00:00:001999-03-01T00:00:00Placebos11.801263923104021e-0022013-02-11T00:00:002013-02-11T00:00:00Viremia11.788637382722400e-0022012-05-01T00:00:002012-05-01T00:00:00Peptic Ulcer Perforation11.787787324907947e-0021988-06-01T00:00:001988-06-01T00:00:00Retreatment11.762795986971446e-0022010-04-08T00:00:002010-04-08T00:00:00Clinical Decision-Making11.749454733402158e-0022018-03-11T00:00:002018-03-11T00:00:00Receptors, Immunologic11.742922373218914e-0021995-08-15T00:00:001995-08-15T00:00:00Duodenal Ulcer11.742852351237147e-0021988-06-01T00:00:001988-06-01T00:00:00Jaundice, Obstructive11.719335319492504e-0022008-01-09T00:00:002008-01-09T00:00:00Genome-Wide Association Study21.710853609172696e-0022011-05-20T00:00:002021-11-09T00:00:00Case-Control Studies21.656301355045498e-0022012-04-24T00:00:002018-01-25T00:00:00Immunoassay11.654033873799004e-0022011-04-01T00:00:002011-04-01T00:00:00Metabolic Syndrome11.641701024770537e-0022018-08-23T00:00:002018-08-23T00:00:00Hepatitis B Antibodies11.637878131261985e-0021988-03-01T00:00:001988-03-01T00:00:00Safety Management11.625500228473480e-0022012-12-10T00:00:002012-12-10T00:00:00Peptide Hydrolases11.621842452718531e-0021990-06-01T00:00:001990-06-01T00:00:00Protein Precursors11.621054276544336e-0022011-04-01T00:00:002011-04-01T00:00:00Mucin-5B21.620479473022823e-0021997-05-15T00:00:001998-10-09T00:00:00Epitopes11.618217508080080e-0021993-12-01T00:00:001993-12-01T00:00:00Base Sequence41.609198181566600e-0021995-08-15T00:00:001999-04-01T00:00:00Intercellular Adhesion Molecule-111.601247499095624e-0022010-10-26T00:00:002010-10-26T00:00:00Secondary Prevention11.584591153802168e-0022013-03-15T00:00:002013-03-15T00:00:00Urea11.583331240557767e-0022009-08-11T00:00:002009-08-11T00:00:00Gallbladder Emptying11.581037044359624e-0022006-07-01T00:00:002006-07-01T00:00:00International Cooperation11.580131243434614e-0022013-04-01T00:00:002013-04-01T00:00:00California11.572893588554158e-0022011-04-01T00:00:002011-04-01T00:00:00Perception11.552680481100497e-0022013-04-01T00:00:002013-04-01T00:00:00Lactulose11.550098014850512e-0021986-06-01T00:00:001986-06-01T00:00:00Linkage Disequilibrium11.546532333716681e-0022011-05-20T00:00:002011-05-20T00:00:00Information Dissemination11.533968202199852e-0022015-01-01T00:00:002015-01-01T00:00:00Genetic Variation11.526950401238287e-0022021-11-09T00:00:002021-11-09T00:00:00Machine Learning11.507002619804763e-0022021-12-01T00:00:002021-12-01T00:00:00Toll-Like Receptor 911.506916387523417e-0022007-11-01T00:00:002007-11-01T00:00:00Glycolysis11.506850406047243e-0021990-11-01T00:00:001990-11-01T00:00:00Estrogen Receptor Modulators11.488027383818008e-0022005-12-27T00:00:002005-12-27T00:00:00Outpatients11.484508173678130e-0022013-11-07T00:00:002013-11-07T00:00:00Disease-Free Survival11.475330694916359e-0022016-04-01T00:00:002016-04-01T00:00:00Sterol Regulatory Element Binding Protein 211.468798969192780e-0022005-12-27T00:00:002005-12-27T00:00:00Silybum marianum11.453685989015525e-0022005-04-13T00:00:002005-04-13T00:00:00Kaplan-Meier Estimate11.452702673610968e-0022016-04-01T00:00:002016-04-01T00:00:00Eating11.435459812474422e-0021992-03-01T00:00:001992-03-01T00:00:00Hydrogen11.431753809057801e-0021986-06-01T00:00:001986-06-01T00:00:00Breath Tests11.393301005099469e-0021986-06-01T00:00:001986-06-01T00:00:00Diabetes Mellitus, Type 211.389043769629997e-0022009-04-01T00:00:002009-04-01T00:00:00Computer Simulation11.384730019394402e-0022018-08-15T00:00:002018-08-15T00:00:00Feasibility Studies11.374214242217193e-0021996-07-01T00:00:001996-07-01T00:00:00Multicenter Studies as Topic11.368942246462124e-0022010-11-09T00:00:002010-11-09T00:00:00DNA, Complementary21.362829939665615e-0021997-05-15T00:00:001998-10-09T00:00:00Fulvestrant11.360874002855475e-0022005-12-27T00:00:002005-12-27T00:00:00ATP Binding Cassette Transporter, Subfamily G, Member 511.352190565259607e-0022004-04-08T00:00:002004-04-08T00:00:00Cell Movement31.347202544904112e-0021993-12-01T00:00:002003-12-01T00:00:00Castration11.343721715088649e-0022004-07-01T00:00:002004-07-01T00:00:00ATP Binding Cassette Transporter, Subfamily G, Member 811.340835288127482e-0022004-04-08T00:00:002004-04-08T00:00:00NK Cell Lectin-Like Receptor Subfamily B11.338108286878193e-0022004-08-01T00:00:002004-08-01T00:00:00Fatty Acid Transport Proteins11.336993143399392e-0022004-04-08T00:00:002004-04-08T00:00:00Riboflavin Deficiency11.326033279508881e-0021983-12-01T00:00:001983-12-01T00:00:00Immunoenzyme Techniques11.318413510851384e-0021987-05-01T00:00:001987-05-01T00:00:00Vitamin B 6 Deficiency11.318242723864965e-0021983-12-01T00:00:001983-12-01T00:00:00High-Throughput Nucleotide Sequencing11.313949582763738e-0022016-12-05T00:00:002016-12-05T00:00:00CD56 Antigen11.302663831977346e-0022004-08-01T00:00:002004-08-01T00:00:00Data Collection11.297781095108163e-0022013-04-01T00:00:002013-04-01T00:00:00Hospitals, Pediatric11.297486517073310e-0022013-06-05T00:00:002013-06-05T00:00:00Ascorbic Acid Deficiency11.293303711160937e-0021983-12-01T00:00:001983-12-01T00:00:00Antigens, CD1d11.276575934345536e-0022004-08-01T00:00:002004-08-01T00:00:00Mice, Transgenic21.276162529714276e-0022006-06-01T00:00:002006-07-01T00:00:00Ovariectomy11.267681110357612e-0022005-12-27T00:00:002005-12-27T00:00:00Down-Regulation11.256365597435562e-0022010-10-26T00:00:002010-10-26T00:00:00Gastrointestinal Transit11.254527497881198e-0022004-04-08T00:00:002004-04-08T00:00:00Estrogen Receptor beta11.253013215575330e-0022004-07-01T00:00:002004-07-01T00:00:00Thiamine Deficiency11.245255381375952e-0021983-12-01T00:00:001983-12-01T00:00:00Patient Reported Outcome Measures11.241856251270172e-0022016-07-20T00:00:002016-07-20T00:00:00Cell Line31.222028609321845e-0021993-12-01T00:00:002004-08-01T00:00:00Regression Analysis11.206852982562316e-0022012-04-29T00:00:002012-04-29T00:00:001,2-Dipalmitoylphosphatidylcholine11.203379023974783e-0022002-09-01T00:00:002002-09-01T00:00:00Molecular Biology11.188643257861404e-0022006-06-01T00:00:002006-06-01T00:00:00Referral and Consultation11.186089387940430e-0022016-02-23T00:00:002016-02-23T00:00:00Enterocytes11.184286073159340e-0022004-04-08T00:00:002004-04-08T00:00:00Integrin alpha Chains11.172732349319722e-0022003-01-01T00:00:002003-01-01T00:00:00Disease Management11.165593047454532e-0022013-08-04T00:00:002013-08-04T00:00:00Clone Cells21.164138517333529e-0021993-12-01T00:00:001998-02-01T00:00:00Becaplermin11.157949461353961e-0022003-01-01T00:00:002003-01-01T00:00:00Sequence Homology, Amino Acid21.154685292967631e-0021995-08-15T00:00:001997-05-15T00:00:00Chemotactic Factors11.152290840803713e-0022003-01-01T00:00:002003-01-01T00:00:00Hydrogen Bonding11.145328434553225e-0022002-09-01T00:00:002002-09-01T00:00:00Rectum11.138439698069505e-0021987-05-01T00:00:001987-05-01T00:00:00Incidence21.137748059298021e-0022007-10-18T00:00:002013-08-04T00:00:00Models, Immunological11.137315748345388e-0022004-08-01T00:00:002004-08-01T00:00:00Interleukin-1311.130388708957755e-0022004-08-01T00:00:002004-08-01T00:00:00Gastrointestinal Motility11.126716729731223e-0022004-04-08T00:00:002004-04-08T00:00:00Comorbidity11.120775681923300e-0022016-07-20T00:00:002016-07-20T00:00:00Drug Carriers11.117459925137520e-0022006-08-01T00:00:002006-08-01T00:00:00Flow Cytometry11.101133748568906e-0022012-04-24T00:00:002012-04-24T00:00:00Longitudinal Studies11.093519960101253e-0022018-08-23T00:00:002018-08-23T00:00:00Ileum11.092611682170474e-0021984-05-01T00:00:001984-05-01T00:00:00Hemodynamics11.080307402675216e-0021992-03-01T00:00:001992-03-01T00:00:00Bile Acids and Salts11.069956556579767e-0022004-01-01T00:00:002004-01-01T00:00:00Cloning, Molecular21.063510266840506e-0021995-08-15T00:00:001997-05-15T00:00:00Lectins, C-Type11.047509319736343e-0022004-08-01T00:00:002004-08-01T00:00:00Prisoners11.044294965768297e-0022005-04-01T00:00:002005-04-01T00:00:00ATP-Binding Cassette Transporters11.034373952876024e-0022004-04-08T00:00:002004-04-08T00:00:00Platelet-Derived Growth Factor11.027325961896468e-0022003-01-01T00:00:002003-01-01T00:00:00Nutritional Status11.020442636865383e-0021989-07-01T00:00:001989-07-01T00:00:00Epidermal Growth Factor19.918865006552450e-0032003-01-01T00:00:002003-01-01T00:00:00Antigens, Surface19.838837822017093e-0032004-08-01T00:00:002004-08-01T00:00:00Diabetes Mellitus19.689392516639816e-0032018-08-23T00:00:002018-08-23T00:00:00Intestine, Small19.645472424136789e-0031986-06-01T00:00:001986-06-01T00:00:00Th1 Cells19.496092747131651e-0032004-08-01T00:00:002004-08-01T00:00:00Th2 Cells19.253877406621709e-0032004-08-01T00:00:002004-08-01T00:00:00Antigen Presentation19.035789202149067e-0032004-08-01T00:00:002004-08-01T00:00:00TATA Box19.020103479679064e-0031998-10-09T00:00:001998-10-09T00:00:00Analysis of Variance18.819099795717730e-0032006-10-01T00:00:002006-10-01T00:00:00Mice, Knockout28.809481482544138e-0032004-01-01T00:00:002004-04-08T00:00:00Models, Animal18.621736040710589e-0032004-07-01T00:00:002004-07-01T00:00:00Anti-Retroviral Agents18.573028246032290e-0032007-10-18T00:00:002007-10-18T00:00:00Ill-Housed Persons18.567849264524511e-0032005-04-01T00:00:002005-04-01T00:00:00Viral Structural Proteins18.556751202369258e-0031998-02-01T00:00:001998-02-01T00:00:00Reactive Oxygen Species18.549408177020270e-0032006-06-01T00:00:002006-06-01T00:00:00Gastrointestinal Neoplasms18.403219427565568e-0031985-10-01T00:00:001985-10-01T00:00:00Chymotrypsin18.235939901729952e-0031997-05-15T00:00:001997-05-15T00:00:00Polymerase Chain Reaction18.098738685332368e-0032006-07-01T00:00:002006-07-01T00:00:00Genomic Library18.093588209347096e-0031997-05-15T00:00:001997-05-15T00:00:00Hepatocytes18.039483528751451e-0032004-08-01T00:00:002004-08-01T00:00:00Peptide Mapping18.031948424929589e-0031997-05-15T00:00:001997-05-15T00:00:00Sphincterotomy, Endoscopic17.983586384070438e-0031996-12-01T00:00:001996-12-01T00:00:00Alcoholism17.955024490497195e-0031988-03-01T00:00:001988-03-01T00:00:00Transfection17.924645473112432e-0032004-08-01T00:00:002004-08-01T00:00:00Feces17.922454579508685e-0032004-04-08T00:00:002004-04-08T00:00:00Consensus Sequence17.899524317416466e-0031997-05-15T00:00:001997-05-15T00:00:00alpha 1-Antichymotrypsin17.861558803578415e-0031996-06-01T00:00:001996-06-01T00:00:00Restriction Mapping17.823317865019608e-0031997-05-15T00:00:001997-05-15T00:00:00Gene Expression Regulation27.742634001680220e-0032004-04-08T00:00:002004-08-01T00:00:00Databases, Factual17.705996085413530e-0032012-06-07T00:00:002012-06-07T00:00:00Prenatal Diagnosis17.683071890380301e-0032004-01-01T00:00:002004-01-01T00:00:00DNA Damage17.614877318386605e-0032006-06-01T00:00:002006-06-01T00:00:00Sepharose17.587439417229700e-0031996-06-01T00:00:001996-06-01T00:00:00Bacterial Proteins17.468391319121938e-0032009-08-11T00:00:002009-08-11T00:00:00Colorectal Neoplasms17.424839066805040e-0031996-07-01T00:00:001996-07-01T00:00:00Neoplasm Invasiveness17.262216233380680e-0032003-12-01T00:00:002003-12-01T00:00:00Scavenger Receptors, Class B17.244204155174783e-0031995-08-15T00:00:001995-08-15T00:00:00alpha 1-Antitrypsin17.227119983550501e-0031996-06-01T00:00:001996-06-01T00:00:00Temperature17.195735732319695e-0032002-09-01T00:00:002002-09-01T00:00:00Receptors, Scavenger17.080703974913756e-0031995-08-15T00:00:001995-08-15T00:00:00Repetitive Sequences, Nucleic Acid17.071290801518350e-0031997-05-15T00:00:001997-05-15T00:00:00Blotting, Southern16.948633672481777e-0031995-08-15T00:00:001995-08-15T00:00:00Health Services Accessibility16.943711247965566e-0032013-04-01T00:00:002013-04-01T00:00:00Epitope Mapping16.788427037332690e-0031995-11-01T00:00:001995-11-01T00:00:00Sequence Alignment16.744712002511662e-0031998-10-09T00:00:001998-10-09T00:00:00Introns16.675126004024883e-0031997-05-15T00:00:001997-05-15T00:00:00DNA Primers16.633264023280609e-0031998-10-09T00:00:001998-10-09T00:00:00Epitopes, T-Lymphocyte16.546916820329633e-0031998-02-01T00:00:001998-02-01T00:00:00Organ Specificity16.371531286063712e-0031998-10-09T00:00:001998-10-09T00:00:00Rural Population16.365248176029945e-0032004-11-01T00:00:002004-11-01T00:00:00Protein Isoforms16.364720638262751e-0031998-10-09T00:00:001998-10-09T00:00:00Hyperplasia16.306969606661152e-0031996-12-01T00:00:001996-12-01T00:00:00Mucous Membrane16.267387040950196e-0031997-05-15T00:00:001997-05-15T00:00:00Cholangiopancreatography, Endoscopic Retrograde16.235155088353695e-0031996-12-01T00:00:001996-12-01T00:00:00Antibodies, Viral16.213118919046149e-0032005-04-13T00:00:002005-04-13T00:00:00von Willebrand Factor16.180990623675482e-0031997-05-15T00:00:001997-05-15T00:00:00Genes, MHC Class I16.127784050984486e-0031993-12-01T00:00:001993-12-01T00:00:00Cells, Cultured25.944250362193633e-0031998-02-01T00:00:001998-10-09T00:00:00CD8 Antigens15.903877605194811e-0031993-12-01T00:00:001993-12-01T00:00:00Interleukin-815.893688974497822e-0031995-11-01T00:00:001995-11-01T00:00:00Vaccinia virus15.790103566597624e-0031993-12-01T00:00:001993-12-01T00:00:00Granulocyte-Macrophage Colony-Stimulating Factor15.725477300725259e-0031995-11-01T00:00:001995-11-01T00:00:00Mutation15.639465886839028e-0032016-12-05T00:00:002016-12-05T00:00:00Exons15.378124540930307e-0031997-05-15T00:00:001997-05-15T00:00:00Carrier Proteins15.330318175471015e-0032004-04-08T00:00:002004-04-08T00:00:00Survival Rate15.223991177086478e-0032005-04-01T00:00:002005-04-01T00:00:00Veterans15.192971018879551e-0032005-04-01T00:00:002005-04-01T00:00:00Infant15.167337014807388e-0032013-06-05T00:00:002013-06-05T00:00:00Cell Proliferation15.068590808637865e-0032006-06-01T00:00:002006-06-01T00:00:00Drug Resistance15.035386407464542e-0031996-06-01T00:00:001996-06-01T00:00:00Pepstatins15.019647402784546e-0031989-12-01T00:00:001989-12-01T00:00:00Protein Processing, Post-Translational15.019615038982793e-0031998-02-01T00:00:001998-02-01T00:00:00Sucralfate15.015776119869655e-0031989-12-01T00:00:001989-12-01T00:00:00Viral Vaccines14.983530252645783e-0031995-11-01T00:00:001995-11-01T00:00:00Child, Preschool14.886864283050420e-0032013-06-05T00:00:002013-06-05T00:00:00Regional Blood Flow14.416741641426210e-0031992-03-01T00:00:001992-03-01T00:00:00HLA Antigens14.369329573670452e-0031993-12-01T00:00:001993-12-01T00:00:00Peptic Ulcer14.332466138483427e-0031989-12-01T00:00:001989-12-01T00:00:00Ireland14.262169300098856e-0031988-03-01T00:00:001988-03-01T00:00:00Sequence Analysis, DNA14.130987855276120e-0031998-10-09T00:00:001998-10-09T00:00:00Mice, Inbred C57BL14.069653161415733e-0032006-07-01T00:00:002006-07-01T00:00:00Anti-Bacterial Agents14.026374520721732e-0031986-06-01T00:00:001986-06-01T00:00:00Tranexamic Acid14.010178270898349e-0031989-12-01T00:00:001989-12-01T00:00:00Cell Line, Tumor13.914341228014039e-0032003-12-01T00:00:002003-12-01T00:00:00Diet13.604625984181568e-0032004-01-01T00:00:002004-01-01T00:00:00Child13.412871729810724e-0032013-06-05T00:00:002013-06-05T00:00:00Carcinoembryonic Antigen13.367868693691866e-0031985-10-01T00:00:001985-10-01T00:00:00Hot Temperature12.950043261007545e-0031989-12-01T00:00:001989-12-01T00:00:00Pregnancy12.796906612360429e-0032004-01-01T00:00:002004-01-01T00:00:00Brain11.761645225352795e-0032002-09-01T00:00:002002-09-01T00:00:00Postoperative Complications18.720580102457445e-0041988-06-01T00:00:001988-06-01T00:00:00Rifqi Affan, Ph.D.RifqiAffan

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617 6677000

1BIDMCBeth Israel Deaconess Medical CenterNeurologyResearch Fellow in NeurologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/39819250Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning. J Neurophysiol. 2025 Feb 01; 133(2):625-637.Affan RO, Bright IM, Pemberton LN, Cruzado NA, Scott BB, Howard MW. J Neurophysiol2025 Feb 01133(2):625-637http://www.ncbi.nlm.nih.gov/pubmed/38076724Advances in cellular resolution microscopy for brain imaging in rats. Neurophotonics. 2023 Oct; 10(4):044304.Kim SJ, Affan RO, Frostig H, Scott BB, Alexander AS. Neurophotonics2023 Oct10(4):044304http://www.ncbi.nlm.nih.gov/pubmed/35926451Everything, everywhere, all at once: Functional specialization and distributed coding in the cerebral cortex. Neuron. 2022 08 03; 110(15):2361-2362.Affan RO, Scott BB. Neuron2022 08 03110(15):2361-2362http://www.ncbi.nlm.nih.gov/pubmed/35533160GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging. IEEE Trans Image Process. 2022; 31:3509-3524.Charles AS, Cermak N, Affan RO, Scott BB, Schiller J, Mishne G. IEEE Trans Image Process202231:3509-3524http://www.ncbi.nlm.nih.gov/pubmed/29778070High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults. Alcohol. 2018 08; 70:51-60.Affan RO, Huang S, Cruz SM, Holcomb LA, Nguyen E, Marinkovic K. Alcohol2018 0870:51-60Motor Cortex15.171890418977901e-0012025-01-17T00:00:002025-01-17T00:00:00Psychomotor Performance14.998990807922997e-0012025-01-17T00:00:002025-01-17T00:00:00Binge Drinking14.786843256873338e-0012018-01-08T00:00:002018-01-08T00:00:00Motor Activity14.551461138122923e-0012025-01-17T00:00:002025-01-17T00:00:00Neurons34.268225828743489e-0012022-05-18T00:00:002025-01-17T00:00:00Brain Waves14.013515489508367e-0012018-01-08T00:00:002018-01-08T00:00:00Cerebral Cortex12.419391561069219e-0012022-08-03T00:00:002022-08-03T00:00:00Movement11.376360554615570e-0012025-01-17T00:00:002025-01-17T00:00:00Brain28.860885100104196e-0022018-01-08T00:00:002022-05-18T00:00:00Calcium17.418131085976622e-0022022-05-18T00:00:002022-05-18T00:00:00Brain Mapping16.565757043500875e-0022022-08-03T00:00:002022-08-03T00:00:00Mice26.099895009348057e-0022022-08-03T00:00:002025-01-17T00:00:00Mice, Inbred C57BL15.888383597798980e-0022025-01-17T00:00:002025-01-17T00:00:00Time Factors14.874368143560055e-0022025-01-17T00:00:002025-01-17T00:00:00Electroencephalography14.525143188753050e-0022018-01-08T00:00:002018-01-08T00:00:00Algorithms14.361086566931570e-0022022-05-18T00:00:002022-05-18T00:00:00Animals24.348475294356540e-0022022-08-03T00:00:002025-01-17T00:00:00Magnetic Resonance Imaging12.723576776503736e-0022022-08-03T00:00:002022-08-03T00:00:00Male22.431898002025514e-0022018-01-08T00:00:002025-01-17T00:00:00Young Adult12.052290424033383e-0022018-01-08T00:00:002018-01-08T00:00:00Female18.760634479129904e-0032018-01-08T00:00:002018-01-08T00:00:00Humans16.092947687230885e-0032018-01-08T00:00:002018-01-08T00:00:00Nikita Agarwal, M.D.NikitaAgarwal

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGeneral MedicineInstructor in MedicineInstructorSurabhi Agarwal, M.B.,B.S.SurabhiAgarwal

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post DocKiran Jay Agarwal-Harding, M.D.KiranAgarwal-Harding

Massachusetts General HospitalWht 53555 Fruit StBoston, MA 02114617/726-2942

1BIDMCBeth Israel Deaconess Medical CenterOrthopedic SurgeryAssistant Professor of Orthopedic Surgery, Part-timeAssistant Professorhttp://www.ncbi.nlm.nih.gov/pubmed/41557466Pediatric Supracondylar Humerus Fractures: Evaluation and Management Approach in Resource-limited Settings. J Am Acad Orthop Surg Glob Res Rev. 2026 Jan 01; 10(1).Chomba D, Mavrommatis S, Krishna SV, Challa ST, Simister SK, Dooregekant A, Mengesha MG, Agarwal-Harding KJ. J Am Acad Orthop Surg Glob Res Rev2026 Jan 0110(1)http://www.ncbi.nlm.nih.gov/pubmed/41180943Is the Timing of Surgery Associated With the Risk of Mortality Among Older Adults Undergoing Operative Hip Fracture Repair? Geriatr Orthop Surg Rehabil. 2025; 16:21514593251366227.Akodu M, Rajesh D, Steele A, Aung N, Zhang C, McTague M, DesRoches C, Wixted J, Agarwal-Harding K, Appleton P, Rodriguez E, Chahal K, Olveczky D. Geriatr Orthop Surg Rehabil202516:21514593251366227http://www.ncbi.nlm.nih.gov/pubmed/41143110The reuse of orthopaedic devices in trauma care. OTA Int. 2025 Dec; 8(4):e453.Dworkin M, Hinchman C, Agarwal-Harding K, Hayda R. OTA Int2025 Dec8(4):e453http://www.ncbi.nlm.nih.gov/pubmed/40901974Assessment of the Mechanical Performance of an Affordable External Fixator (AEFIX) Designed for Resource-Limited Settings. J Bone Joint Surg Am. 2025 Oct 15; 107(20):2289-2299.Momenzadeh K, Garcia MJ, Zhao L, Chainani P, Simister SK, Hua C, Miller T, Höntzsch D, Nazarian A, Agarwal-Harding KJ. J Bone Joint Surg Am2025 Oct 15107(20):2289-2299http://www.ncbi.nlm.nih.gov/pubmed/40896920Rethinking Global Orthopedic Education: Centering Needs, Fostering Collaboration, and Building Networks. J Surg Educ. 2025 10; 82(10):103661.Kadiyala S, Powis E, Agarwal-Harding KJ. J Surg Educ2025 1082(10):103661http://www.ncbi.nlm.nih.gov/pubmed/40172568The Transformative Impact and Persisting Challenges of Intramedullary Nailing in Low- and Middle-Income Countries: Commentary on an article by Aditya Subramanian, et al.: "Delayed Surgery Increases the Rate of Infection in Closed Diaphyseal Tibial and Femoral Fractures". J Bone Joint Surg Am. 2025 Apr 02; 107(7):e31.Agarwal-Harding KJ. J Bone Joint Surg Am2025 Apr 02107(7):e31http://www.ncbi.nlm.nih.gov/pubmed/40146811Access to Orthopaedic Devices in Low and Middle-Income Countries: Challenges and Opportunities. J Bone Joint Surg Am. 2025 May 21; 107(10):1154-1160.Dworkin M, Woolley PM, Shahab F, Noe MC, Barry R, Chomba D, Makasa E, Singh Pradhan NM, Byiringiro JC, Agarwal-Harding KJ. J Bone Joint Surg Am2025 May 21107(10):1154-1160http://www.ncbi.nlm.nih.gov/pubmed/39928712Risk Factors for Amputation and Prolonged Hospitalization Among Children Who Received Traditional Bonesetting in Ethiopia. J Bone Joint Surg Am. 2025 May 21; 107(10):1050-1062.Adem EG, Morgan-Asiedu PK, Mengesha MG, Keko M, Mo C, Bussa S, Alemu E, Zerihun Y, Derilo HT, Areis M, Reda KT, Workneh WA, Shiferaw BA, Jira MC, Gula HB, Geneti MB, Martin C, Agarwal-Harding KJ, Harrison WJ. J Bone Joint Surg Am2025 May 21107(10):1050-1062http://www.ncbi.nlm.nih.gov/pubmed/39522553Outcomes of external versus internal fixation for traumatic lower limb fractures in low- and middle-income countries. Bone Jt Open. 2024 Nov 11; 5(11):1020-1026.Pigeolet M, Sana H, Askew MR, Jaswal S, Ortega PF, Bradley SR, Shah A, Mita C, Corlew DS, Saeed A, Makasa E, Agarwal-Harding KJ. Bone Jt Open2024 Nov 115(11):1020-1026http://www.ncbi.nlm.nih.gov/pubmed/40018394Technical Priorities for Orthopaedic Trauma Care Development in Malawi. Malawi Med J. 2024 Sep; 36(3):185-207.Agarwal-Harding KJ, Mody K, Amlani LM, Nanyumba K, Chokotho L, Banza LN, Lubega N, Bates JJ, Young S, Mkandawire N, Maina S, Manda K, Manjolo G, Mankhokwe TM, Mkochi VL, Mpanga C, Msukuma MS, Mukuzunga C, Munthali B, Mwafulirwa K, Naminga F, Ngulube CD, Nyamulani N, Theis JC, Yesaya MH, Chawinga M. Malawi Med J2024 Sep36(3):185-207http://www.ncbi.nlm.nih.gov/pubmed/39619411The utility of low-cost negative pressure wound therapy in Cameroon. Pan Afr Med J. 2024; 48:151.Amlani L, Ndasi H, Aminake G, Penda X, Timam S, Lechtig A, Dejean CB, Agarwal-Harding K. Pan Afr Med J202448:151http://www.ncbi.nlm.nih.gov/pubmed/39042502Epidemiology and Management of Pediatric Fractures in Malawi. J Am Acad Orthop Surg Glob Res Rev. 2024 07 01; 8(7).Cassidy BP, Yeramosu T, Mbomuwa FJ, Chidothi P, Wu HH, Martin C, Harrison WJ, Chokotho L, Agarwal-Harding KJ. 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Therapy17.261630519876459e-0012024-08-05T00:00:002024-08-05T00:00:00Tibial Fractures17.259492440799743e-0012025-09-03T00:00:002025-09-03T00:00:00Fractures, Bone37.203025202484837e-0012019-05-15T00:00:002025-02-10T00:00:00Ankle Fractures26.920752093690623e-0012021-02-17T00:00:002022-10-18T00:00:00Alaska Natives16.907660799632541e-0012022-02-01T00:00:002022-02-01T00:00:00Health Priorities16.802376896242716e-0012024-10-16T00:00:002024-10-16T00:00:00Musculoskeletal Diseases25.876639809484451e-0012021-12-21T00:00:002022-02-01T00:00:00Hospital Bed Capacity15.728612502815841e-0012019-11-20T00:00:002019-11-20T00:00:00Health Services Accessibility35.672706559833802e-0012016-11-02T00:00:002025-03-27T00:00:00Indians, North American15.557906687268338e-0012022-02-01T00:00:002022-02-01T00:00:00Resource-Limited Settings35.213607346844859e-0012024-03-15T00:00:002026-01-01T00:00:00Ankle Joint15.054225710206503e-0012021-02-17T00:00:002021-02-17T00:00:00Global Health44.272958534779867e-0012014-03-13T00:00:002025-09-01T00:00:00Fractures, Open23.871169743266449e-0012023-08-31T00:00:002024-07-01T00:00:00Time-to-Treatment13.440330018640127e-0012019-05-15T00:00:002019-05-15T00:00:00Accidental Falls13.373978221357548e-0012019-05-15T00:00:002019-05-15T00:00:00Muscle, Skeletal23.138403056410804e-0012010-04-08T00:00:002019-05-15T00:00:00Accidents, Traffic13.020437735804186e-0012015-03-18T00:00:002015-03-18T00:00:00Athletic Injuries12.928054395404111e-0012019-05-15T00:00:002019-05-15T00:00:00Health Services Needs and Demand12.879308730023911e-0012016-11-02T00:00:002016-11-02T00:00:00Gait Disorders, Neurologic12.651395167512851e-0012010-04-08T00:00:002010-04-08T00:00:00Physical Exertion12.629994373313200e-0012010-04-08T00:00:002010-04-08T00:00:00Orthopedic Procedures12.524457382074135e-0012016-11-02T00:00:002016-11-02T00:00:00Delivery of Health Care12.492142388452177e-0012024-10-16T00:00:002024-10-16T00:00:00Tendons12.368907437555708e-0012010-04-08T00:00:002010-04-08T00:00:00Health Knowledge, Attitudes, Practice12.358675255546310e-0012021-02-17T00:00:002021-02-17T00:00:00Medicine, African Traditional12.219206018452898e-0012025-02-10T00:00:002025-02-10T00:00:00Cameroon12.186885272073100e-0012024-08-05T00:00:002024-08-05T00:00:00Gait12.135315922593500e-0012010-04-08T00:00:002010-04-08T00:00:00Telemedicine12.099329392566836e-0012022-02-01T00:00:002022-02-01T00:00:00Brachial Artery12.096690628522727e-0012026-01-01T00:00:002026-01-01T00:00:00Quality of Life22.072118919467541e-0012020-07-07T00:00:002023-09-01T00:00:00Wrist Fractures11.995460617941896e-0012024-03-26T00:00:002024-03-26T00:00:00Walking11.877859042048998e-0012010-04-08T00:00:002010-04-08T00:00:00Fracture Fixation, Intramedullary21.809758308740409e-0012018-10-01T00:00:002021-03-24T00:00:00Wound Infection11.809141848563140e-0012024-08-05T00:00:002024-08-05T00:00:00Child101.806347016026397e-0012010-04-08T00:00:002026-01-01T00:00:00Materials Testing11.743582574799964e-0012025-09-03T00:00:002025-09-03T00:00:00Knee Joint11.716683509131660e-0012010-04-08T00:00:002010-04-08T00:00:00Multiple Trauma11.672378875575082e-0012023-08-31T00:00:002023-08-31T00:00:00Diaphyses11.557186908391078e-0012019-11-20T00:00:002019-11-20T00:00:00Joint Dislocations11.547548788591233e-0012023-08-31T00:00:002023-08-31T00:00:00Humans281.540112520152406e-0012010-04-08T00:00:002026-01-01T00:00:00Health Resources11.509433689577462e-0012026-01-01T00:00:002026-01-01T00:00:00Length of Stay21.468736157690675e-0012021-03-01T00:00:002025-02-10T00:00:00Triage11.423379285023376e-0012026-01-01T00:00:002026-01-01T00:00:00Cooperative Behavior11.400692807616950e-0012025-09-01T00:00:002025-09-01T00:00:00Amputation, Surgical11.398837972967572e-0012025-02-10T00:00:002025-02-10T00:00:00After-Hours Care11.394328418494165e-0012019-05-15T00:00:002019-05-15T00:00:00Child, Preschool51.381401899928897e-0012015-03-18T00:00:002025-02-10T00:00:00Radius Fractures11.378850781521797e-0012024-03-26T00:00:002024-03-26T00:00:00Biomechanical Phenomena11.367974460357982e-0012025-09-03T00:00:002025-09-03T00:00:00Poisson Distribution11.358887751456171e-0012019-05-15T00:00:002019-05-15T00:00:00Equipment Design11.291174405037944e-0012025-09-03T00:00:002025-09-03T00:00:00Socioeconomic Factors21.184154623082419e-0012015-03-18T00:00:002023-09-01T00:00:00Feasibility Studies21.176061594754450e-0012022-10-18T00:00:002024-08-05T00:00:00Vascular Diseases11.174927090150608e-0012024-03-15T00:00:002024-03-15T00:00:00Specialties, Surgical11.169798976001859e-0012020-07-07T00:00:002020-07-07T00:00:00Infant41.107307625500281e-0012015-03-18T00:00:002025-02-10T00:00:00Workforce11.086477130565024e-0012019-11-20T00:00:002019-11-20T00:00:00Wound Healing19.748325096635759e-0022024-08-05T00:00:002024-08-05T00:00:00Adolescent59.507350956219719e-0022015-03-18T00:00:002025-02-10T00:00:00Emergency Medical Services19.330336843507546e-0022024-10-16T00:00:002024-10-16T00:00:00Referral and Consultation18.465122911183633e-0022024-07-01T00:00:002024-07-01T00:00:00Hydrodynamics18.309789432826829e-0022012-01-01T00:00:002012-01-01T00:00:00Hospitals18.048958605266213e-0022023-09-01T00:00:002023-09-01T00:00:00Radiography17.907472764241522e-0022021-02-17T00:00:002021-02-17T00:00:00Male97.776254138381271e-0022010-04-08T00:00:002025-02-10T00:00:00Bone Nails27.428417048230890e-0022020-07-21T00:00:002021-03-24T00:00:00Treatment Outcome47.191117959439279e-0022020-07-21T00:00:002024-08-05T00:00:00Registries16.687353771784174e-0022024-07-01T00:00:002024-07-01T00:00:00Retrospective Studies66.611765202417741e-0022019-05-15T00:00:002024-03-26T00:00:00Infant, Newborn26.304771282720328e-0022015-03-18T00:00:002019-05-15T00:00:00Hand26.205904858275323e-0022020-07-07T00:00:002024-03-15T00:00:00Adult56.057536535524942e-0022015-03-18T00:00:002024-08-05T00:00:00Multivariate Analysis16.033024105440300e-0022019-05-15T00:00:002019-05-15T00:00:00Female76.009686797117015e-0022010-04-08T00:00:002025-02-10T00:00:00Anti-Bacterial Agents15.678406776647735e-0022024-08-05T00:00:002024-08-05T00:00:00Models, Biological25.565245164704258e-0022010-04-08T00:00:002012-01-01T00:00:00Hydrocephalus15.494916760940796e-0022012-01-01T00:00:002012-01-01T00:00:00Prospective Studies24.828439645079502e-0022024-08-05T00:00:002025-02-10T00:00:00Ethiopia14.737283218728251e-0022025-02-10T00:00:002025-02-10T00:00:00Hospitals, Public14.720515080736277e-0022024-03-26T00:00:002024-03-26T00:00:00Cost-Benefit Analysis34.710178566276044e-0022018-10-01T00:00:002021-03-24T00:00:00Middle Aged34.331713779579699e-0022015-03-18T00:00:002024-08-05T00:00:00Volunteers14.061238242923888e-0022021-12-21T00:00:002021-12-21T00:00:00Fibula14.001112839157813e-0022022-10-18T00:00:002022-10-18T00:00:00Haiti13.678670308251197e-0022021-02-08T00:00:002021-02-08T00:00:00Bone Screws13.641890926363477e-0022022-10-18T00:00:002022-10-18T00:00:00Delphi Technique13.566876225364318e-0022023-08-31T00:00:002023-08-31T00:00:00Humerus13.517765958888772e-0022020-07-21T00:00:002020-07-21T00:00:00Costs and Cost Analysis13.187016345271063e-0022022-10-18T00:00:002022-10-18T00:00:00Computer Simulation13.104339721274708e-0022010-04-08T00:00:002010-04-08T00:00:00Risk Factors23.059503412291487e-0022019-05-15T00:00:002025-02-10T00:00:00Incidence13.050141826974871e-0022015-03-18T00:00:002015-03-18T00:00:00Education, Medical, Continuing12.940990368497498e-0022021-02-08T00:00:002021-02-08T00:00:00Fracture Fixation, Internal12.794141731716370e-0022022-10-18T00:00:002022-10-18T00:00:00Algorithms12.653539991773675e-0022015-03-18T00:00:002015-03-18T00:00:00United States12.497955259532438e-0022022-02-01T00:00:002022-02-01T00:00:00Young Adult22.478063976592949e-0022015-03-18T00:00:002024-03-26T00:00:00Income12.401439984773716e-0022021-12-21T00:00:002021-12-21T00:00:00COVID-1912.064209093497959e-0022021-02-08T00:00:002021-02-08T00:00:00Intracranial Pressure11.873267439860227e-0022012-01-01T00:00:002012-01-01T00:00:00Research Personnel11.591673526600453e-0022012-01-01T00:00:002012-01-01T00:00:00Quality-Adjusted Life Years11.586797020168946e-0022014-03-13T00:00:002014-03-13T00:00:00Health Policy11.504197691907441e-0022018-10-01T00:00:002018-10-01T00:00:00History, 21st Century11.463400685955978e-0022012-01-01T00:00:002012-01-01T00:00:00Clinical Competence11.354825838710723e-0022021-02-08T00:00:002021-02-08T00:00:00History, 20th Century11.311964269758869e-0022012-01-01T00:00:002012-01-01T00:00:00Biomedical Research11.186396834321460e-0022018-10-01T00:00:002018-10-01T00:00:00Research Design11.184158899064550e-0022018-10-01T00:00:002018-10-01T00:00:00Reproducibility of Results11.182320884167828e-0022021-02-08T00:00:002021-02-08T00:00:00Pandemics11.066112640126157e-0022021-02-08T00:00:002021-02-08T00:00:00Models, Theoretical19.931134173880300e-0032012-01-01T00:00:002012-01-01T00:00:00SARS-CoV-219.150178556944402e-0032021-02-08T00:00:002021-02-08T00:00:00Julia Sroda Agudogo, M.D.JuliaAgudogo

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterObstetrics Gynecology & Repro. Bio.Clinical Fellow in Obstetrics, Gynecology and Reproductive BiologyFellow or Post DocLaura Patricia Aguilar Franco, M.D.LauraAguilar Franco

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineResearch Fellow in MedicineFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=199249591@LauraAguilarMD201520182015201720182022202320232023202320242025University of Yucatan, School of MedicineMerida, MexicoMD2019School of Public Health, Harvard T.H CHANBoston, MAMPH2025EpidemiologyBeth Israel Deaconess Medical Center Boston, MA 2025Research Fellowship - Heart Failure and Heart Transplant http://www.ncbi.nlm.nih.gov/pubmed/41507643Development of Validity Evidence of a Standardized Competency Tool for Internal Jugular Vein Point of Care Ultrasound: Consensus Recommendations from International Experts. J Gen Intern Med. 2026 Jan 08.Aguilar Franco L, Rosenberg N, Mohanty A, Baston C, Gargani L, Kimura BJ, Wang L, Wang MK, Zhang K, Ma IWY, Cool JA. J Gen Intern Med2026 Jan 08http://www.ncbi.nlm.nih.gov/pubmed/41297830Have We Been Overlooking Lipoprotein(a) in Heart Failure? J Card Fail. 2026 Feb; 32(2):391-393.Aguilar Franco L, Zhang AL, Garan AR. J Card Fail2026 Feb32(2):391-393Saeed Ahmad, M.B.,B.S.SaeedAhmad

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyResearch Fellow in MedicineFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=265200845King Edward Medical UniversityLahoreMBBS06/2024Medicinehttp://www.ncbi.nlm.nih.gov/pubmed/41696665Nonadherence to Antiviral Therapy Leading to Severe Hepatic Decompensation in a Patient With Chronic Hepatitis B. ACG Case Rep J. 2026 Feb; 13(2):e01999.Ahmad S, Paracha S, Ali R, Akbar SMA, Asif MA, Saeed MO, Bai R, Afzal HMT, Shah SB, Lau DTY. ACG Case Rep J2026 Feb13(2):e01999http://www.ncbi.nlm.nih.gov/pubmed/41325127Letter to the Editor: Detrimental effects of diabetes mellitus in alcoholic liver disease. Hepatol Commun. 2025 Dec 01; 9(12).Akbar Syed MA, Abbas M, Asif MA, Bai R, Saeed MO, Paracha S, Ahmad S, Afzal Hafiz MT. Hepatol Commun2025 Dec 019(12)http://www.ncbi.nlm.nih.gov/pubmed/39651846Letter: Should HBV Therapy Be Stopped Based on HBsAg Level Alone? Aliment Pharmacol Ther. 2025 Jan; 61(2):402-403.Khan NA, Shah SB, Choudhary UIJ, Ullah A, Ahmad S, Patwardhan V. Aliment Pharmacol Ther2025 Jan61(2):402-403http://www.ncbi.nlm.nih.gov/pubmed/38434828Beneficial Effects of Natural Alkaloids from Berberis glaucocarpa as Antidiabetic Agents: An In Vitro, In Silico, and In Vivo Approach. ACS Omega. 2024 Feb 27; 9(8):9813-9822.Alamzeb M, Shah SWA, Hussain H, Zahoor M, Ahmad S, Mughal EU, Ahmad S, Ullah I, Khan S, Ullah A, Ghias M, Ullah R, Ali EA. ACS Omega2024 Feb 279(8):9813-9822http://www.ncbi.nlm.nih.gov/pubmed/33623730Impact of pangolin bootleg market on the dynamics of COVID-19 model. Results Phys. 2021 Apr; 23:103913.Ullah A, Ahmad S, Rahman GU, Alqarni MM, Mahmoud EE. Results Phys2021 Apr23:103913http://www.ncbi.nlm.nih.gov/pubmed/32109202Hepatitis-C Virus and Cirrhosis: An Overview from Khyber Pakhtunkhwa Province of Pakistan. Viral Immunol. 2020 06; 33(5):396-403.Ullah A, Rehman IU, Ahmad J, Gohar M, Ahmad S, Ahmad B. Viral Immunol2020 0633(5):396-403http://www.ncbi.nlm.nih.gov/pubmed/26019581Fungal biotransformation of ezetimibe. Biotechnol Biotechnol Equip. 2014 Sep 03; 28(5):934-940.Pervaiz I, Ahmad S, Khaliq FH, Arshad A, Imran M, Khan BA, Ullah A, Ali U, Iqbal K, Usman M, Bibi H, Khan NU, Mahmood W. Biotechnol Biotechnol Equip2014 Sep 0328(5):934-940http://www.ncbi.nlm.nih.gov/pubmed/25169514Genetic susceptibility to esophageal cancer due to CYP1A1 gene variant rs4646903 in tobacco addicted patients of Pashtun ethnicity: a case control study in Khyber Pakhtunkhwa province of Pakistan. Asian Pac J Cancer Prev. 2014; 15(16):6715-20.Saeed M, Ali S, Javed N, Khisroon M, Muhammad B, Khuda F, Ahmad S, Ismail M. Asian Pac J Cancer Prev201415(16):6715-20http://www.ncbi.nlm.nih.gov/pubmed/22418457Biological characterization and phylogenetic analysis of a novel genetic group of Newcastle disease virus isolated from outbreaks in commercial poultry and from backyard poultry flocks in Pakistan. Infect Genet Evol. 2012 Jul; 12(5):1010-9.Munir M, Cortey M, Abbas M, Qureshi ZU, Afzal F, Shabbir MZ, Khan MT, Ahmed S, Ahmad S, Baule C, Ståhl K, Zohari S, Berg M. Infect Genet Evol2012 Jul12(5):1010-9Cytochrome P-450 CYP1A111.031692944150603e-0012014-01-01T00:00:002014-01-01T00:00:00Hepacivirus19.603055307296483e-0022020-02-28T00:00:002020-02-28T00:00:00Newcastle Disease19.342699861187469e-0022012-03-06T00:00:002012-03-06T00:00:00Newcastle disease virus19.310835577607754e-0022012-03-06T00:00:002012-03-06T00:00:00Poultry19.100013806201726e-0022012-03-06T00:00:002012-03-06T00:00:00Genes, Viral18.340010813191322e-0022012-03-06T00:00:002012-03-06T00:00:00Pakistan37.986827267092023e-0022012-03-06T00:00:002020-02-28T00:00:00Hepatitis C17.736324869540012e-0022020-02-28T00:00:002020-02-28T00:00:00Liver Cirrhosis17.294460515732461e-0022020-02-28T00:00:002020-02-28T00:00:00Viral Envelope Proteins16.939759399828552e-0022012-03-06T00:00:002012-03-06T00:00:00Tobacco Use Disorder16.886550499705661e-0022014-01-01T00:00:002014-01-01T00:00:00Genetic Association Studies15.421959022271949e-0022014-01-01T00:00:002014-01-01T00:00:00Esophageal Neoplasms14.939301865062847e-0022014-01-01T00:00:002014-01-01T00:00:00Genotype22.407023452083753e-0022014-01-01T00:00:002020-02-28T00:00:00Hemagglutination Tests12.341382660210175e-0022012-03-06T00:00:002012-03-06T00:00:00Genetic Predisposition to Disease12.246369714954019e-0022014-01-01T00:00:002014-01-01T00:00:00RNA, Viral12.194509777280936e-0022020-02-28T00:00:002020-02-28T00:00:00Viral Load12.067597403502950e-0022020-02-28T00:00:002020-02-28T00:00:00Sequence Alignment11.708291621155262e-0022012-03-06T00:00:002012-03-06T00:00:00Cluster Analysis11.394194404261365e-0022012-03-06T00:00:002012-03-06T00:00:00Phylogeny11.277306664584124e-0022012-03-06T00:00:002012-03-06T00:00:00Prevalence11.179719138813570e-0022020-02-28T00:00:002020-02-28T00:00:00Disease Outbreaks11.164440172004042e-0022012-03-06T00:00:002012-03-06T00:00:00Base Sequence11.088389161580830e-0022012-03-06T00:00:002012-03-06T00:00:00Sequence Analysis, DNA11.046291070342872e-0022012-03-06T00:00:002012-03-06T00:00:00Molecular Sequence Data19.695457937877627e-0032012-03-06T00:00:002012-03-06T00:00:00Ethnicity18.795552296096349e-0032014-01-01T00:00:002014-01-01T00:00:00Case-Control Studies17.477535647893303e-0032014-01-01T00:00:002014-01-01T00:00:00Polymorphism, Single Nucleotide16.728652650748550e-0032014-01-01T00:00:002014-01-01T00:00:00Aged, 80 and over16.570941865713563e-0032020-02-28T00:00:002020-02-28T00:00:00Aged26.369346651392979e-0032014-01-01T00:00:002020-02-28T00:00:00Young Adult15.950410280624703e-0032020-02-28T00:00:002020-02-28T00:00:00Adult25.701361387296428e-0032014-01-01T00:00:002020-02-28T00:00:00Middle Aged25.700981867593208e-0032014-01-01T00:00:002020-02-28T00:00:00Male24.435066912213519e-0032014-01-01T00:00:002020-02-28T00:00:00Risk Factors13.842507176421077e-0032014-01-01T00:00:002014-01-01T00:00:00Humans22.919454300955220e-0032014-01-01T00:00:002020-02-28T00:00:00Female12.540058115505872e-0032020-02-28T00:00:002020-02-28T00:00:00Animals12.417215980701806e-0032012-03-06T00:00:002012-03-06T00:00:00Munif Ahmad Hatem, M.D.MunifAhmad Hatem

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterOrthopedic SurgeryMember of the Faculty of Orthopedic SurgeryOther Facultyhttp://www.ncbi.nlm.nih.gov/pubmed/41281458Sagittal Orientation of the Acetabulum and Its Relationship to Spinopelvic Alignment: Three-Dimensional Assessment of 3700 Individuals. Orthop J Sports Med. 2025 Nov; 13(11):23259671251390432.Hatem MA, Movahhedi M, Kim JY, Singh M, De Silva SA, Bixby S, Kim YJ, Novais EN, Kiapour AM. Orthop J Sports Med2025 Nov13(11):23259671251390432https://academic.oup.com/jhps/advance-article/doi/10.1093/jhps/hnaf049/8315080Normative metrics and sex-specific differences in 3D acetabular morphology in asymptomatic young adults: implications for hip preservation surgery. . Journal of Hip Preservation Surgery. 2025.Novais EN, Hatem M, Movahhedi M, De Silva S, Kim YJ, Kiapour A. . Journal of Hip Preservation Surgery2025http://www.ncbi.nlm.nih.gov/pubmed/39043148The predominant insertion of the ischiofemoral ligament is a merging to the iliofemoral ligament as demonstrated on magnetic resonance arthrogram studies. Acta Radiol. 2024 Sep; 65(9):1080-1086.Hatem M, Badejo M, McCarroll M, Feng R, Martin HD. Acta Radiol2024 Sep65(9):1080-1086http://www.ncbi.nlm.nih.gov/pubmed/37091761Imaging changes following surgery for ischiofemoral impingement. Proc (Bayl Univ Med Cent). 2023; 36(3):329-334.Hatem M, Feng R, Teel J, Martin HD. Proc (Bayl Univ Med Cent)202336(3):329-334http://www.ncbi.nlm.nih.gov/pubmed/36661128Acute Adductor Muscle Injury: A Systematic Review on Diagnostic Imaging, Treatment, and Prevention. Am J Sports Med. 2023 11; 51(13):3591-3603.Farrell SG, Hatem M, Bharam S. Am J Sports Med2023 1151(13):3591-3603http://www.ncbi.nlm.nih.gov/pubmed/36866321Anterior Electronic Hip Pain Drawings Are Helpful for Diagnosis of Intra-articular Sources of Pain: Lateral or Posterior Drawings Are Unreliable. Arthrosc Sports Med Rehabil. 2023 Feb; 5(1):e87-e92.Feng R, Hatem M, Martin HD. Arthrosc Sports Med Rehabil2023 Feb5(1):e87-e92http://www.ncbi.nlm.nih.gov/pubmed/35754596Hip physical examination extension loss and radiographic osseous findings in patients with low back pain and nonarthritic hips. Proc (Bayl Univ Med Cent). 2022; 35(4):455-459.Feng R, Hatem M, Nimmons SJ, Disantis A, Martin RL, Martin HD. Proc (Bayl Univ Med Cent)202235(4):455-459http://www.ncbi.nlm.nih.gov/pubmed/34541009Surgical Outcomes of Inguinal-, Pubic-, and Adductor-Related Chronic Pain in Athletes: A Systematic Review Based on Surgical Technique. Orthop J Sports Med. 2021 Sep; 9(9):23259671211023116.Hatem M, Martin RL, Bharam S. Orthop J Sports Med2021 Sep9(9):23259671211023116http://www.ncbi.nlm.nih.gov/pubmed/34219926Usefulness of magnetic resonance imaging to diagnose greater trochanteric-ischial impingement. Proc (Bayl Univ Med Cent). 2021 Mar 30; 34(4):460-463.Hatem M, Canavan KE, Martin RL, Dawkins J, Martin HD. Proc (Bayl Univ Med Cent)2021 Mar 3034(4):460-463http://www.ncbi.nlm.nih.gov/pubmed/33460710Low Back Pain Improves After Surgery for Lesser Trochanteric-Ischial Impingement. Arthroscopy. 2021 05; 37(5):1503-1509.Hatem M, Martin HD. Arthroscopy2021 0537(5):1503-1509http://www.ncbi.nlm.nih.gov/pubmed/33415172Anteroinferior Hip Instability in Flexion During Dynamic Arthroscopic Examination Is Associated With Abnormal Anterior Acetabular Horn. Orthop J Sports Med. 2020 Dec; 8(12):2325967120965564.Hatem MA, Helal A, Khoury AN, Martin HD. Orthop J Sports Med2020 Dec8(12):2325967120965564http://www.ncbi.nlm.nih.gov/pubmed/33948195Hip-spine syndrome: rationale for ischiofemoral impingement, femoroacetabular impingement and abnormal femoral torsion leading to low back pain. J Hip Preserv Surg. 2020 Aug; 7(3):390-400.Khoury AN, Hatem M, Bowler J, Martin HD. J Hip Preserv Surg2020 Aug7(3):390-400http://www.ncbi.nlm.nih.gov/pubmed/33678956Frequency of ischiofemoral space discrepancy when comparing magnetic resonance images of distinct institutions for the same patient. Proc (Bayl Univ Med Cent). 2020 Nov 20; 34(2):242-246.Hatem M, Martin RL, Nimmons SJ, Martin HD. Proc (Bayl Univ Med Cent)2020 Nov 2034(2):242-246http://www.ncbi.nlm.nih.gov/pubmed/33117848Spinopelvic Parameters Do Not Predict the Sagittal Orientation of the Acetabulum. Orthop J Sports Med. 2020 Oct; 8(10):2325967120957420.Hatem M, Nimmons SJ, Khoury AN, Martin HD. Orthop J Sports Med2020 Oct8(10):2325967120957420http://www.ncbi.nlm.nih.gov/pubmed/32828933Femoral Derotation Osteotomy Improves Hip and Spine Function in Patients With Increased or Decreased Femoral Torsion. Arthroscopy. 2021 01; 37(1):111-123.Hatem M, Khoury AN, Erickson LR, Jones AL, Martin HD. Arthroscopy2021 0137(1):111-123http://www.ncbi.nlm.nih.gov/pubmed/33100526Carbon dioxide gas endoscopy of the deep gluteal space. Proc (Bayl Univ Med Cent). 2020 Jul 06; 33(4):550-553.Martin HD, Hatem M, Gómez-Hoyos J, Pérez-Carro L, Khoury AN. Proc (Bayl Univ Med Cent)2020 Jul 0633(4):550-553http://www.ncbi.nlm.nih.gov/pubmed/32773704Snapping of the Sciatic Nerve and Sciatica Provoked by Impingement Between the Greater Trochanter and Ischium: A Case Report. JBJS Case Connect. 2020 Jul-Sep; 10(3):e20.00014.Hatem M, Martin HD, Safran MR. JBJS Case Connect2020 Jul-Sep10(3):e20.00014http://www.ncbi.nlm.nih.gov/pubmed/28630728Parameters for assessment of the inferior acetabulum morphology in 300 adult hips. J Hip Preserv Surg. 2017 Jan; 4(1):97-105.Hatem MA, da Cunha LAM, Abdo JCM, Martin HD. J Hip Preserv Surg2017 Jan4(1):97-105http://www.ncbi.nlm.nih.gov/pubmed/27011866A MRI study of the lesser trochanteric version and its relationship to proximal femoral osseous anatomy. J Hip Preserv Surg. 2015 Dec; 2(4):410-6.Schröder RG, Reddy M, Hatem MA, Gómez-Hoyos J, Toye L, Khoury A, Martin HD. J Hip Preserv Surg2015 Dec2(4):410-6http://www.ncbi.nlm.nih.gov/pubmed/26229912Alignment of the tibial component in total knee arthroplasty procedures using an intramedullary or extramedullary guide: double-blind randomized prospective study. Rev Bras Ortop. 2015 Mar-Apr; 50(2):168-73.da Rocha Moreira Rezende B, Fuchs T, Nishi RN, Hatem MA, da Silva LM, Fuchs R, de Alencar PG. Rev Bras Ortop2015 Mar-Apr50(2):168-73http://www.ncbi.nlm.nih.gov/pubmed/25278353Diagnosis and 2-year outcomes of endoscopic treatment for ischiofemoral impingement. Arthroscopy. 2015 Feb; 31(2):239-46.Hatem MA, Palmer IJ, Martin HD. Arthroscopy2015 Feb31(2):239-46http://www.ncbi.nlm.nih.gov/pubmed/24908256Function of the ligamentum teres in limiting hip rotation: a cadaveric study. Arthroscopy. 2014 Sep; 30(9):1085-91.Martin HD, Hatem MA, Kivlan BR, Martin RL. Arthroscopy2014 Sep30(9):1085-91http://www.ncbi.nlm.nih.gov/pubmed/26229810Evaluation of the results from proximal fixation of uncemented conical femoral components in Dorr type C femurs. Rev Bras Ortop. 2014 May-Jun; 49(3):260-6.Ahmad Hatem M, Ferreira da Luz B, Nishimoto Nishi R, Gilberto Cimbalista de Alencar P. Rev Bras Ortop2014 May-Jun49(3):260-6http://www.ncbi.nlm.nih.gov/pubmed/24183195Monopolar radiofrequency use in deep gluteal space endoscopy: sciatic nerve safety and fluid temperature. Arthroscopy. 2014 Jan; 30(1):60-4.Martin HD, Palmer IJ, Hatem M. Arthroscopy2014 Jan30(1):60-4Long-term outcomes of percutaneous vertebroplasty for treatment of vertebral osteoporotic fractures. Coluna / Columna. 2006; 2(6):61-67.Barros, D.S., de Abreu, E.V., Simões, M.S., Hatem, M.A. . Coluna / Columna20062(6):61-67Hip Joint58.169654093386011e-0012014-06-06T00:00:002024-07-23T00:00:00Femur47.685221298627092e-0012014-09-30T00:00:002021-01-15T00:00:00Ischium25.476778873636971e-0012014-09-30T00:00:002020-07-01T00:00:00Ligaments, Articular25.270330460238539e-0012014-06-06T00:00:002024-07-23T00:00:00Soccer13.334202992701191e-0012023-01-20T00:00:002023-01-20T00:00:00Torsion Abnormality13.197922114752826e-0012020-08-21T00:00:002020-08-21T00:00:00Sciatic Neuropathy13.181809596409037e-0012020-07-01T00:00:002020-07-01T00:00:00Osteotomy12.271824579727158e-0012020-08-21T00:00:002020-08-21T00:00:00Arthroscopy32.089853114658164e-0012013-10-30T00:00:002020-08-21T00:00:00Buttocks12.007308222755403e-0012013-10-30T00:00:002013-10-30T00:00:00Hip11.962610409949163e-0012014-09-30T00:00:002014-09-30T00:00:00Spine11.957286679856392e-0012020-08-21T00:00:002020-08-21T00:00:00Athletic Injuries11.890092801872756e-0012023-01-20T00:00:002023-01-20T00:00:00Range of Motion, Articular21.865167900774501e-0012014-06-06T00:00:002020-08-21T00:00:00Low Back Pain11.839678780354662e-0012021-01-15T00:00:002021-01-15T00:00:00Radio Waves11.821642357934390e-0012013-10-30T00:00:002013-10-30T00:00:00Body Fluids11.799472317016461e-0012013-10-30T00:00:002013-10-30T00:00:00Bone Diseases11.686428193173608e-0012014-09-30T00:00:002014-09-30T00:00:00Sciatic Nerve11.563373666913262e-0012013-10-30T00:00:002013-10-30T00:00:00Rupture21.328643351382162e-0012014-06-06T00:00:002023-01-20T00:00:00Temperature11.247904714886990e-0012013-10-30T00:00:002013-10-30T00:00:00Magnetic Resonance Imaging49.620133589106741e-0022014-09-30T00:00:002024-07-23T00:00:00Groin19.473205737509161e-0022023-01-20T00:00:002023-01-20T00:00:00Cadaver27.646661951464430e-0022013-10-30T00:00:002014-06-06T00:00:00Tendons17.183695706762469e-0022023-01-20T00:00:002023-01-20T00:00:00Patient Positioning16.943631248291393e-0022021-01-15T00:00:002021-01-15T00:00:00Radiofrequency Therapy15.091123211144885e-0022013-10-30T00:00:002013-10-30T00:00:00Disability Evaluation14.929494593778187e-0022020-08-21T00:00:002020-08-21T00:00:00Follow-Up Studies34.878859771808806e-0022014-09-30T00:00:002021-01-15T00:00:00Rotation14.667757333694737e-0022014-06-06T00:00:002014-06-06T00:00:00Lumbar Vertebrae14.244452242967417e-0022021-01-15T00:00:002021-01-15T00:00:00Adult53.700170062315385e-0022014-09-30T00:00:002024-07-23T00:00:00Young Adult33.662490374900901e-0022014-09-30T00:00:002024-07-23T00:00:00Middle Aged53.563098871650459e-0022014-09-30T00:00:002024-07-23T00:00:00Muscle, Skeletal13.305581910210551e-0022023-01-20T00:00:002023-01-20T00:00:00Ultrasonography13.199672279525780e-0022020-07-01T00:00:002020-07-01T00:00:00Adolescent33.156915893156789e-0022014-09-30T00:00:002023-01-20T00:00:00Retrospective Studies33.141768203287274e-0022014-09-30T00:00:002024-07-23T00:00:00Male52.878347941511530e-0022014-09-30T00:00:002024-07-23T00:00:00Humans82.721783503467437e-0022013-10-30T00:00:002024-07-23T00:00:00Endoscopy12.640192234190804e-0022014-09-30T00:00:002014-09-30T00:00:00Female42.083519119571526e-0022014-09-30T00:00:002024-07-23T00:00:00Pain11.909287396873203e-0022014-09-30T00:00:002014-09-30T00:00:00Aged21.865094100448169e-0022021-01-15T00:00:002024-07-23T00:00:00Tomography, X-Ray Computed11.570779618018054e-0022020-07-01T00:00:002020-07-01T00:00:00Treatment Outcome11.278681471238871e-0022021-01-15T00:00:002021-01-15T00:00:00Mohamed Ahmed, M.B.,B.S.MohamedAhmed

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post DocMuneeb Ahmed, M.D.MuneebAhmed

Beth Israel Deaconess Medical CenterRadiology Rosenberg W308FOne Deaconess RdBoston, MA 02215617/754-251942.33852520000000-71.10928630000000

1BIDMCBeth Israel Deaconess Medical CenterRadiologyMiriam H. Stoneman Professor of RadiologyFull ProfessorCo-InvestigatorCenter for Translational Cancer NanomedicineNIH2010-09-012015-07-31TORCHILIN, VLADIMIR PThe proposed Center is designed to provide rapid translation of our bench studies of a broad set of nanomedicines for cancer with in-depth physico-chemical, in vivo disposition and imaging studies into a real industrial product by developing the appropriate technologies and scaling them up for manufacture of test batches of candidates for preclinical and clinical evaluation under GMP/GLP conditions. We will establish a Center for Cancer Nanotechnology Excellence (CCNE) at Northeastern University (NU), Boston with collaborations at Beth Israel Deaconess Hospital;Harvard Medical School;Rutgers, The State University of New Jersey, Auburn University, and Nemucore Medical Innovations, Inc. The proposed CCNE will collaborate with the NIH-designated Cancer Institute of New Jersey and SPORE. The CCNE will utilize the support and facilities of the NU-based Center for High-rate Nanomanufacturing (NSF-funded Nanoscale Science and Engineering Center). Cross-disciplinary collaboration will enable integration of the fundamental biological knowledge base with physical science and engineering approaches for intimate involvement in scale-up and manufacture to rapidly translate bench research into animal testing and GMP production and to narrow the gap between discovery and development of anticancer therapeutics. The CCNE will concentrate on multifunctional, targeted devices that will bypass current biological barriers to delivery of multiple therapeutic agents at high local concentrations, with appropriate timing, directly to cancer cells. The main objective of the Center will be to develop, test pre-clinically in vitro and in vivo, characterize, scale up and manufacture under GMP conditions test batches of the most promising nanopreparations for cancer. Nanocarriers will include polymeric micelles, liposomes, polymeric particles, and dendrimers, while the drugs to be used will include pro-apoptotic agents, DNA, and siRNA together with diagnostic labels. The proposed CCNE will: a) create and supply appropriate "starting materials";b) establish proof-of-concept through in vitro studies;c) conduct pharmacologic studies with animal models;d) perform a variety of in vivo model studies;e) provide quality assurance;and f) develop production schemes for a broad set of nanopreparations for cancer treatment and diagnosis.Principal InvestigatorModulating systemic pro-oncogenic effects of focal image-guided tumor ablationNIH2016-09-092021-08-31AHMED, MUNEEB? DESCRIPTION (provided by applicant): Minimally-invasive, energy-based radiofrequency (RF) ablation is now in widespread clinical use to treat a wide range of small focal primary and metastatic tumors in the liver, kidney, and lung. Yet, we and others have recently confirmed initial clinical suspicions that local tumor ablation can have broad systemic pro-oncogenic effects, stimulating distant tumor growth and de novo oncogenesis. We have identified three key mediators (Interleukin-6, the HGF/c-Met complex, and VEGF) that are increased locally and/or systemically in concert with periablational recruitment of inflammatory cell populations, and have determined that these are key contributors to secondary systemic pro-oncogenic effects. Our preliminary studies also suggest that tumor receptor expression can identify those tumors that are most susceptible to such `off-target' tumorigenesis. Similarly, we demonstrate that well-selected use of adjuvant drugs to block key mediators can reduce early signs of oncogenic stimulation, though long-term survival studies are still required. Accordingly, we propose to systematically study these issues as a basis for developing a paradigm of combination therapy to block `off- target' pro-oncogenic effects in susceptible tumors with the intent of improving overall ablation outcome. In this proposal we will initially study the relative influence of three mediators (IL-6, HGF/c-Met, and VEGF) using selective gene silencing on the production of pro-oncogenic factors (Aim 1a). Next, we will study how selective mediator silencing affects three key cell populations (neutrophils, macrophages, and activated myofibroblasts) recruited to the ablation zone (Aim 1b), followed by selective depletion/inhibition of these cell populations to identify cellular contributions to key mediator production (Aim 1c). In Aim 2, we will overexpress or silence of IL-6, c-met, and VEGF tumor receptors to determine which distant tumors are most susceptible to `off-target' hepatic RFA effects and suppress stimulation of distant tumor growth for receptor positive or negative tumor lines using adjuvant receptor inhibitors. Finally, in Aim 3 we will perform long-term endpoint survival studies in pre-clinical models that simulate commonly encountered clinical situations, including hepatic ablation: 1) in the presence of a distant primary tumor in the liver and breast, 2) in cirrhotic liver pre-disposed to de novo hepati tumorigenesis, and 3) in the setting of diffuse progressive micrometastases. Thus, we will characterize key molecules and cell populations in a common mechanistic pathway that underlies hepatic RF ablation-induced pro-oncogenic effects, identify key tumor biomarkers that can be used to predict susceptibility to these effects and show response to adjuvant drug inhibition, and identify regimens that can be applied in three relevant pre-clinical / in situ tumo models that closely reproduce current clinical hepatic RF ablation applications. Thus, with the completion of this proposal we will be well-positioned to translate our paradigm into clinical studies in keeping with our track record of rapid translation of combination therapy regimens that have improved local image-guided tumor ablation efficacy.http://www.ncbi.nlm.nih.gov/pubmed/41577005Safety and Effectiveness of Radiation Lobectomy for Primary Liver Cancers Using Resin Microspheres. J Vasc Interv Radiol. 2026 Jan 21; 37(5):108543.Murcia DJ, Malik MS, Ali RS, Shenoy-Bhangle A, Bullock A, Curry M, Catana AM, Eckhoff D, Dinh D, Weinstein JL, Ahmed M, Sarwar A. J Vasc Interv Radiol2026 Jan 2137(5):108543http://www.ncbi.nlm.nih.gov/pubmed/41332383Minimally Invasive Diagnosis of a Cardiac Mass: Resolving Clinical-Imaging Discordance. Circ Cardiovasc Imaging. 2026 Feb; 19(2):e018599.Wanderley MRB, Asnani AH, Albayouk E, Kunamalla A, Ahmed M, Laham R, Towery EA, VanderLaan PA, Upshaw JN, Hoeger CW. Circ Cardiovasc Imaging2026 Feb19(2):e018599http://www.ncbi.nlm.nih.gov/pubmed/41308972Left versus Right Portal Vein Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation in Patients with Grade 1 Hepatic Encephalopathy. J Vasc Interv Radiol. 2026 Mar; 37(3):107930.Ramalingam V, Sarwar A, Faiz Z, Tahir MM, Huang D, Ali R, Yang L, Curry M, Weinstein J, Ahmed M. J Vasc Interv Radiol2026 Mar37(3):107930http://www.ncbi.nlm.nih.gov/pubmed/41217471Histopathologic analysis of intrahepatic cholangiocarcinoma treated with transarterial radioembolization using Yttrium-90 resin microspheres. Eur J Nucl Med Mol Imaging. 2026 Mar; 53(4):2455-2465.Tahir MM, Nasser IA, Odeh M, Ali A, De Paepe KN, Kim C, Nizamic S, Dinh D, Weinstein JL, Shenoy-Bhangle AS, Bullock A, Dib M, Eckhoff D, Ahmed M, Sarwar A. Eur J Nucl Med Mol Imaging2026 Mar53(4):2455-2465http://www.ncbi.nlm.nih.gov/pubmed/41013745Real-time 3D confirmation of complete ablation with margins as a local cure for colorectal liver metastases: the ACCLAIM trial. Trials. 2025 Sep 26; 26(1):360.Sofocleous CT, Callstrom MR, Petre EN, Gonen M, Rilling WS, Ahmed M, Kelekis A, Soulen MC, Pereira P, Crocetti L, Dupuy DE, Solbiati L. Trials2025 Sep 2626(1):360http://www.ncbi.nlm.nih.gov/pubmed/40762798Histopathologic outcomes of hepatocellular carcinoma treated with transarterial radioembolization with yttrium-90 resin microspheres. Eur J Nucl Med Mol Imaging. 2026 Jan; 53(2):876-889.Sarwar A, Nasser I, Weinstein JL, Odeh M, Babar H, Dinh D, Curry M, Bullock A, Eckhoff D, Dib M, Parker JA, Ahmed M. Eur J Nucl Med Mol Imaging2026 Jan53(2):876-889http://www.ncbi.nlm.nih.gov/pubmed/40685123The Aldosteronoma Resolution Score as a Predictive Metric for Outcomes after Radiofrequency Ablation for Primary Aldosteronism. J Vasc Interv Radiol. 2025 11; 36(11):1705-1713.Moussa M, Hamam O, Maaly A, Elkholy M, Farghaly M, Abiola G, Faintuch S, Sacks B, Vaidya A, Ahmed M, Sarwar A. J Vasc Interv Radiol2025 1136(11):1705-1713http://www.ncbi.nlm.nih.gov/pubmed/40784692Portal Vein Embolization: Efficacy, Methodology, and Alternatives. Tech Vasc Interv Radiol. 2025 Sep; 28(3):101061.Dinh DC, Ahmed M. Tech Vasc Interv Radiol2025 Sep28(3):101061http://www.ncbi.nlm.nih.gov/pubmed/40588024Prediction of Recurrence of Hepatocellular Carcinoma Following Radiation Segmentectomy with Resin Microspheres Based on Underdosed Tumor Volume on Yttrium-90 Positron Emission Tomography/CT Dosimetry. J Vasc Interv Radiol. 2025 10; 36(10):1576-1586.e1.Vo NH, Malik MS, Tahir MM, Parker JA, Tsai LL, Dinh D, Lam M, Weinstein J, Ahmed M, Sarwar A. J Vasc Interv Radiol2025 1036(10):1576-1586.e1http://www.ncbi.nlm.nih.gov/pubmed/40524034Safety and Efficacy of Primary Stent Placement for Hepatic Artery Kinks in Liver Transplant Recipients. Cardiovasc Intervent Radiol. 2025 Jul; 48(7):1055-1062.Ramalingam V, Sarwar A, Shami SMU, Weinstein J, Lee D, Curry M, Eckhoff D, Ahmed M. Cardiovasc Intervent Radiol2025 Jul48(7):1055-1062http://www.ncbi.nlm.nih.gov/pubmed/40425433Night Float vs. Traditional Call in Interventional Radiology: Impacts on Resident Wellness and Nighttime Clinical Service. Acad Radiol. 2025 Aug; 32(8):4853-4859.Metrouh O, Bulman J, Degerstedt S, DeBacker SS, Ahmed M, Weinstein J. Acad Radiol2025 Aug32(8):4853-4859http://www.ncbi.nlm.nih.gov/pubmed/40413459Accuracy of cross-sectional imaging in predicting tumor viability using the LI-RADS treatment response algorithm after image-guided percutaneous ablation with radiologic-pathologic explant correlation. Cancer Imaging. 2025 May 24; 25(1):65.Shenoy-Bhangle AS, Malik MS, Ali A, Jiang NN, Andrabi SY, Singal A, Curry MP, Catana MA, Eckhoff DE, Faintuch S, Ahmed M, Nasser IA, Sarwar A. Cancer Imaging2025 May 2425(1):65http://www.ncbi.nlm.nih.gov/pubmed/40407939Hand Motion Analysis of Different Segments of a Procedure: Is One Segment Enough? J Med Syst. 2025 May 23; 49(1):69.Weinstein J, Ali H, Metrouh O, Sarwar A, Mitchell JD, Baribeau V, Wong VT, Matyal R, Palmer MR, MacLellan C, Ahmed M. J Med Syst2025 May 2349(1):69http://www.ncbi.nlm.nih.gov/pubmed/39809884Hepatocellular Carcinoma with Vascular Invasion Treated with Resin Yttrium-90 Transarterial Radioembolization Using Single Compartment Dosimetry. Cardiovasc Intervent Radiol. 2025 Apr; 48(4):485-492.Tahir MM, Ali A, Nasser I, Dinh DC, Catana AM, Bullock A, Curry MP, Eckhoff D, Weinstein JL, Ahmed M, Sarwar A. Cardiovasc Intervent Radiol2025 Apr48(4):485-492http://www.ncbi.nlm.nih.gov/pubmed/39979003Comparison of wired and wireless electromagnetic hand motion tracking in central venous access: Are they equivalent enough to cut the cord? Med Eng Phys. 2025 Feb; 136:104280.Ali H, Metrouh O, Ahmed M, Mitchell JD, Baribeau V, Palmer MR, MacLellan C, Weinstein J. Med Eng Phys2025 Feb136:104280http://www.ncbi.nlm.nih.gov/pubmed/39586537Safety and Effectiveness of Early Primary Stent Placement for Hepatic Artery Stenosis in Liver Transplant Recipients. J Vasc Interv Radiol. 2025 03; 36(3):425-434.Ramalingam V, Shami SMU, Weinstein J, Lee D, Curry M, Eckhoff D, Ahmed M, Sarwar A. J Vasc Interv Radiol2025 0336(3):425-434http://www.ncbi.nlm.nih.gov/pubmed/39514046Proceedings from an international consensus meeting on ablation in urogenital diseases. Insights Imaging. 2024 Nov 08; 15(1):267.Iezzi R, Contegiacomo A, De Filippis A, Gunn AJ, Atwell T, Mcclure T, Jing Z, Posa A, Scrofani AR, Maresca A, Madoff DC, Goldberg SN, Kelekis A, Filippiadis D, Sala E, Ahmed M. Insights Imaging2024 Nov 0815(1):267http://www.ncbi.nlm.nih.gov/pubmed/39291585Ultrasound-guided percutaneous thrombin injection for the management of upper extremity pseudoaneurysms: 20?years of tertiary care center experience. J Clin Ultrasound. 2025 Jan; 53(1):113-121.McCarthy CJ, Weinstein JL, Bulman JC, Schroeppel DeBacker SE, Berkowitz SJ, Dowlatshahi AS, Ahmed M, Faintuch S. J Clin Ultrasound2025 Jan53(1):113-121http://www.ncbi.nlm.nih.gov/pubmed/39160358The Effect of Time Pressure on Motion Economy and Smoothness of Interventional Radiology Trainee Performance in Simulated Central Venous Line Placement. Cardiovasc Intervent Radiol. 2024 Oct; 47(10):1365-1371.Metrouh O, Ali H, DeBacker SES, McCarthy CJ, MacLellan C, Palmer MR, Ahmed M, Weinstein JL. Cardiovasc Intervent Radiol2024 Oct47(10):1365-1371http://www.ncbi.nlm.nih.gov/pubmed/38964631Utility of Intraoperative Neuromonitoring to Protect against Adjacent Nerve Injury in Musculoskeletal and Lymph Nodal Cryoablation. J Vasc Interv Radiol. 2024 10; 35(10):1498-1507.Moussa M, Alswang JM, Degerstedt SG, Honhart J, Abiola GO, Ramalingam V, Ahmed M. J Vasc Interv Radiol2024 1035(10):1498-1507http://www.ncbi.nlm.nih.gov/pubmed/38922448Analyzing the Evolution of Needle and Ultrasound Probe Manipulation Skills of Interventional Radiology Trainees With Time and Experience. Simul Healthc. 2025 Feb 01; 20(1):16-20.Weinstein JL, Ali H, Mitchell JD, Sarwar A, Palmer MR, MacLellan C, Matyal R, Ahmed M. Simul Healthc2025 Feb 0120(1):16-20http://www.ncbi.nlm.nih.gov/pubmed/38713023Efficacy and Safety of Radiation Segmentectomy with 90Y Resin Microspheres for Hepatocellular Carcinoma. Radiology. 2024 05; 311(2):e231386.Sarwar A, Malik MS, Vo NH, Tsai LL, Tahir MM, Curry MP, Catana AM, Bullock AJ, Parker JA, Eckhoff DE, Nasser IA, Weinstein JL, Ahmed M. Radiology2024 05311(2):e231386http://www.ncbi.nlm.nih.gov/pubmed/38483589Highest 3-month international normalized ratio (INR): a predictor of bleeding following ultrasound-guided liver biopsy. Eur Radiol. 2024 Oct; 34(10):6416-6424.Vo NH, Sari MA, Grimaldi E, Berchmans E, Curry MP, Ahmed M, Siewert B, Brook A, Brook OR. Eur Radiol2024 Oct34(10):6416-6424http://www.ncbi.nlm.nih.gov/pubmed/38426887Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with Hyperpolarized 13C Pyruvate MRI and Mass Spectrometry. Radiol Imaging Cancer. 2024 03; 6(2):e230056.Dou Q, Grant AK, Coutinto de Souza P, Moussa M, Nasser I, Ahmed M, Tsai LL. Radiol Imaging Cancer2024 036(2):e230056http://www.ncbi.nlm.nih.gov/pubmed/38142888The Impact of Implementation of a Commercial Inferior Vena Cava Filter Database Program on Filter Retrieval versus Physician Tracking over a 9-Year Period: A Retrospective, Observational Study. J Vasc Interv Radiol. 2024 04; 35(4):576-582.Bulman JC, Ali H, Sikaria D, Ahmed M, Weinstein JL. J Vasc Interv Radiol2024 0435(4):576-582http://www.ncbi.nlm.nih.gov/pubmed/37985479Evaluation of Primary Lymphedema with Intranodal Lymphangiography. Cardiovasc Intervent Radiol. 2024 Feb; 47(2):238-244.Kim C, Ali H, Tsai LL, Bulman J, Singhal D, Carroll B, Ahmed M, Weinstein J. Cardiovasc Intervent Radiol2024 Feb47(2):238-244http://www.ncbi.nlm.nih.gov/pubmed/38071028Expanding the Horizons of Interventional Radiology With Advanced Image Guidance and Robotics. Tech Vasc Interv Radiol. 2023 Sep; 26(3):100910.Cornelis FH, Solomon SB, Ahmed M. Tech Vasc Interv Radiol2023 Sep26(3):100910http://www.ncbi.nlm.nih.gov/pubmed/37883367Combined thermal ablation and liposomal granulocyte-macrophage colony stimulation factor increases immune cell trafficking in a small animal tumor model. PLoS One. 2023; 18(10):e0293141.Moussa M, Chowdhury MR, Mwin D, Fatih M, Selveraj G, Abdelmonem A, Farghaly M, Dou Q, Filipczak N, Levchenko T, Torchilin VP, Boussiotis V, Goldberg SN, Ahmed M. PLoS One202318(10):e0293141http://www.ncbi.nlm.nih.gov/pubmed/37857902Routine radiology-pathology concordance evaluation of CT-guided percutaneous lung biopsies increases the number of cancers identified. Eur Radiol. 2024 May; 34(5):3271-3283.Rigiroli F, Hamam O, Kavandi H, Brook A, Berkowitz S, Ahmed M, Siewert B, Brook OR. Eur Radiol2024 May34(5):3271-3283http://www.ncbi.nlm.nih.gov/pubmed/37805172Percutaneous CT-Guided Cryoablation for Locally Recurrent Prostate Cancer: Technical Feasibility, Safety, and Effectiveness. J Vasc Interv Radiol. 2024 01; 35(1):36-44.Ramalingam V, Degerstedt S, Moussa M, Tsai LL, Einstein D, Ahmed M. J Vasc Interv Radiol2024 0135(1):36-44http://www.ncbi.nlm.nih.gov/pubmed/37770545Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation. Sci Rep. 2023 09 28; 13(1):16341.Markezana A, Paldor M, Liao H, Ahmed M, Zorde-Khvalevsky E, Rozenblum N, Stechele M, Salvermoser L, Laville F, Goldmann S, Rosenberg N, Andrasina T, Ricke J, Galun E, Goldberg SN. Sci Rep2023 09 2813(1):16341http://www.ncbi.nlm.nih.gov/pubmed/37707549Safety profile and technical success of narrow window CT-guided percutaneous biopsy with blunt needle approach in the abdomen and pelvis. Eur Radiol. 2024 Apr; 34(4):2364-2373.Rigiroli F, Camacho A, Chung A, Andrabi SY, Brook A, Siewert B, Ahmed M, Brook OR. Eur Radiol2024 Apr34(4):2364-2373http://www.ncbi.nlm.nih.gov/pubmed/37696431Association between Patient Experience Scores and Low Utilization of Hepatocellular Carcinoma Treatment in the United States: A Surveillance, Epidemiology, and End Results-Consumer Assessment of Healthcare Providers and Systems Analysis (SEER-CAHPS). J Vasc Interv Radiol. 2024 01; 35(1):102-112.e5.Malik MS, Subrize MW, Ou J, Curry MP, Parikh ND, Novack V, Weinstein JL, Ahmed M, Sarwar A. J Vasc Interv Radiol2024 0135(1):102-112.e5http://www.ncbi.nlm.nih.gov/pubmed/37763708Image-Guided Prostate Cryoablation: State-of-the-Art. Medicina (Kaunas). 2023 Sep 02; 59(9).Ramalingam V, McCarthy CJ, Degerstedt S, Ahmed M. Medicina (Kaunas)2023 Sep 0259(9)http://www.ncbi.nlm.nih.gov/pubmed/37638802Angiography with cone-beam CT versus contrast-enhanced MRI for living donor transplant imaging: Is MRI enough? Clin Anat. 2024 Mar; 37(2):185-192.Ali H, Weinstein J, Sarwar A, Evenson A, Raven K, Curry MP, Ahmed M. Clin Anat2024 Mar37(2):185-192http://www.ncbi.nlm.nih.gov/pubmed/37414212New Frontiers in the Role of Locoregional Therapies in Breast Cancer: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel. J Vasc Interv Radiol. 2023 10; 34(10):1835-1842.Daye D, Panagides J, Norton L, Ahmed M, Fukuma E, Ward RC, Gomez D, Kokabi N, Vogl T, Abi-Jaoudeh N, Deipolyi A. J Vasc Interv Radiol2023 1034(10):1835-1842http://www.ncbi.nlm.nih.gov/pubmed/37348786Radiofrequency Ablation-Induced Tumor Growth Is Suppressed by MicroRNA-21 Inhibition in Murine Models of Intrahepatic Colorectal Carcinoma. J Vasc Interv Radiol. 2023 10; 34(10):1785-1793.e2.Salvermoser L, Goldberg SN, Laville F, Markezana A, Stechele M, Ahmed M, Wildgruber M, Kazmierczak PM, Alunni-Fabbroni M, Galun E, Ricke J, Paldor M. J Vasc Interv Radiol2023 1034(10):1785-1793.e2http://www.ncbi.nlm.nih.gov/pubmed/37330210Evaluation of an Artificial Intelligence Chatbot for Delivery of IR Patient Education Material: A Comparison with Societal Website Content. J Vasc Interv Radiol. 2023 10; 34(10):1760-1768.e32.McCarthy CJ, Berkowitz S, Ramalingam V, Ahmed M. J Vasc Interv Radiol2023 1034(10):1760-1768.e32http://www.ncbi.nlm.nih.gov/pubmed/37374045Interventional Approach to Portal Vein Thrombosis and Liver Transplantation: State of the Art. Life (Basel). 2023 May 26; 13(6).Ramalingam V, Yang LM, McCarthy CJ, Ahmed M. Life (Basel)2023 May 2613(6)http://www.ncbi.nlm.nih.gov/pubmed/37187437Evaluation of Technical Performance of Ultrasound-Guided Procedures through Hand Motion Analysis: An Exploration of Motion Metrics. J Vasc Interv Radiol. 2023 08; 34(8):1337-1344.Weinstein JL, Ali H, Sarwar A, Dadour JR, Brook OR, Mitchell JD, Matyal R, Palmer MR, MacLellan C, Ahmed M. J Vasc Interv Radiol2023 0834(8):1337-1344http://www.ncbi.nlm.nih.gov/pubmed/37182668Transjugular Intrahepatic Portosystemic Shunt and Thrombectomy (TIPS-Thrombectomy) for Symptomatic Acute Noncirrhotic Portal Vein Thrombosis. J Vasc Interv Radiol. 2023 08; 34(8):1373-1381.e3.Shalvoy MR, Ahmed M, Weinstein JL, Ramalingam V, Malik MS, Ali A, Shenoy-Bhangle AS, Curry MP, Sarwar A. J Vasc Interv Radiol2023 0834(8):1373-1381.e3http://www.ncbi.nlm.nih.gov/pubmed/36972387Stage migration as a surrogate of survival in hepatocellular carcinoma treated with transarterial chemoembolization. Hepatol Commun. 2023 04 01; 7(4).Kassab I, Singal AG, Ali A, Narasimman M, Arvind A, Ahmed M, Joshi S, Manzoor K, Rich N, Chen VL, Zhao Z, Sarwar A, Parikh ND. Hepatol Commun2023 04 017(4)http://www.ncbi.nlm.nih.gov/pubmed/36521795Technical Feasibility of Suction Thrombectomy Using a Large-Bore Aspiration System in the Portomesenteric Venous System. J Vasc Interv Radiol. 2023 03; 34(3):351-356.Ramalingam V, Weinstein J, Gimenez J, Curry M, Yang L, Sarwar A, Ahmed M. J Vasc Interv Radiol2023 0334(3):351-356http://www.ncbi.nlm.nih.gov/pubmed/36475810Factors Associated With Complete Pathologic Necrosis of Hepatocellular Carcinoma on Explant Evaluation After Locoregional Therapy: A National Analysis Using the UNOS Database. AJR Am J Roentgenol. 2023 05; 220(5):727-735.Sarwar A, Bonder A, Hassan L, Malik MS, Novack V, Curry M, Ahmed M. AJR Am J Roentgenol2023 05220(5):727-735http://www.ncbi.nlm.nih.gov/pubmed/36423815MR Imaging-Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. J Vasc Interv Radiol. 2023 Mar; 34(3):395-403.e5.Santana JG, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald LA, Boustani A, Walsh JJ, Kucukkaya AS, Malpani R, Madoff DC, Goldberg SN, Ahmed M, Joshi N, Coman D, Chapiro J. J Vasc Interv Radiol2023 Mar34(3):395-403.e5http://www.ncbi.nlm.nih.gov/pubmed/36414114Patient and Provider Perspectives of Telehealth and In-Person Interventional Radiology Clinic Visits. J Vasc Interv Radiol. 2023 Mar; 34(3):466-473.Bulman JC, El-Gabalawy F, Martinez LA, Sarwar A, Weinstein JL, Faintuch S, Ahmed M. J Vasc Interv Radiol2023 Mar34(3):466-473http://www.ncbi.nlm.nih.gov/pubmed/36162723PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation. Cell Mol Gastroenterol Hepatol. 2023; 15(1):61-75.Dou Q, Grant AK, Callahan C, Coutinho de Souza P, Mwin D, Booth AL, Nasser I, Moussa M, Ahmed M, Tsai LL. Cell Mol Gastroenterol Hepatol202315(1):61-75http://www.ncbi.nlm.nih.gov/pubmed/35978173Filter-Assisted Shunt Embolization of Large Portosystemic Shunts: Technical Feasibility, Safety, and Outcomes. Cardiovasc Intervent Radiol. 2022 Oct; 45(10):1540-1546.Ramalingam V, Weinstein J, Sarwar A, Gimenez J, Ahmed M. Cardiovasc Intervent Radiol2022 Oct45(10):1540-1546http://www.ncbi.nlm.nih.gov/pubmed/35857766Myofibroblasts: A key promoter of tumorigenesis following radiofrequency tumor ablation. PLoS One. 2022; 17(7):e0266522.Moussa M, Mwin D, Liao H, Atac MF, Markezana A, Galun E, Goldberg SN, Ahmed M. PLoS One202217(7):e0266522http://www.ncbi.nlm.nih.gov/pubmed/35798144Outcomes of Postprocedural Closeout Checklist Implementation to Prevent Adverse Events during Interventional Radiology Procedures: An Initiative to Improve Outcomes. J Vasc Interv Radiol. 2022 10; 33(10):1240-1246.Siewert B, Brook OR, Swedeen S, Ahmed M, Kruskal JB. J Vasc Interv Radiol2022 1033(10):1240-1246http://www.ncbi.nlm.nih.gov/pubmed/35581474Extrinsic Arterial Compression by a Venous Stent Graft in a Patient Undergoing Dialysis. Cardiovasc Intervent Radiol. 2022 08; 45(8):1225-1227.Randhawa A, Bulman JC, Brook OR, Mehta SV, Faintuch S, Ahmed M, Weinstein JL. Cardiovasc Intervent Radiol2022 0845(8):1225-1227http://www.ncbi.nlm.nih.gov/pubmed/35286421Is routine imaging necessary prior to percutaneous abscess catheter removal? Abdom Radiol (NY). 2022 08; 47(8):2604-2611.Sari MA, Camacho A, Ahmed M, Siewert B, Brook I, Brook OR. Abdom Radiol (NY)2022 0847(8):2604-2611http://www.ncbi.nlm.nih.gov/pubmed/35170360Echocardiographic and Other Preprocedural Predictors of Heart Failure After TIPS Placement in Patients With Cirrhosis: A Single-Center 15-Year Analysis. AJR Am J Roentgenol. 2022 07; 219(1):110-118.Ali A, Sarwar A, Patwardhan VR, Fraiche AM, Tahir MM, Luo M, Weinstein JL, Hussain MS, Curry MP, Ahmed M. AJR Am J Roentgenol2022 07219(1):110-118http://www.ncbi.nlm.nih.gov/pubmed/35114399Gender-Based Survey Analysis of Research and Mentoring in Interventional Radiology. J Vasc Interv Radiol. 2022 05; 33(5):578-585.e3.Li S, Sun VH, Galla N, Salazar G, Lewis T, Ahmed M, Daye D. J Vasc Interv Radiol2022 0533(5):578-585.e3http://www.ncbi.nlm.nih.gov/pubmed/35248319Osteoplasty, Fixation, and Ablations in Peripheral Bones: It is Time for Interventional Radiologists to Move Forward. Tech Vasc Interv Radiol. 2022 Mar; 25(1):100796.Cornelis FH, Solomon SB, Ahmed M. Tech Vasc Interv Radiol2022 Mar25(1):100796http://www.ncbi.nlm.nih.gov/pubmed/34862123Mentorship in Interventional Radiology: Addressing Obstacles to Pursuing Research and Innovation Among IR Trainees. Acad Radiol. 2022 08; 29(8):1275-1281.Xiang DH, Snyder A, Capua JD, Galla N, Tischfield DJ, Lewis T, Somani S, Sucher A, Ahmed M, Daye D. Acad Radiol2022 0829(8):1275-1281http://www.ncbi.nlm.nih.gov/pubmed/34780925Concordance Assessment of Pathology Results with Imaging Findings after Image-Guided Biopsy. J Vasc Interv Radiol. 2022 02; 33(2):159-168.e1.Camacho A, Chung AD, Rigiroli F, Sari MA, Brook A, Siewert B, Ahmed M, Brook OR. J Vasc Interv Radiol2022 0233(2):159-168.e1http://www.ncbi.nlm.nih.gov/pubmed/34581627Consensus Guidelines for the Definition of Time-to-Event End Points in Image-guided Tumor Ablation: Results of the SIO and DATECAN Initiative. Radiology. 2021 12; 301(3):533-540.Puijk RS, Ahmed M, Adam A, Arai Y, Arellano R, de Baère T, Bale R, Bellera C, Binkert CA, Brace CL, Breen DJ, Brountzos E, Callstrom MR, Carrafiello G, Chapiro J, de Cobelli F, Coupé VMH, Crocetti L, Denys A, Dupuy DE, Erinjeri JP, Filippiadis D, Gangi A, Gervais DA, Gillams AR, Greene T, Guiu B, Helmberger T, Iezzi R, Kang TW, Kelekis A, Kim HS, Kröncke T, Kwan S, Lee MW, Lee FT, Lee EW, Liang P, Lissenberg-Witte BI, Lu DS, Madoff DC, Mauri G, Meloni MF, Morgan R, Nadolski G, Narayanan G, Newton I, Nikolic B, Orsi F, Pereira PL, Pua U, Rhim H, Ricke J, Rilling W, Salem R, Scheffer HJ, Sofocleous CT, Solbiati LA, Solomon SB, Soulen MC, Sze D, Uberoi R, Vogl TJ, Wang DS, Wood BJ, Goldberg SN, Meijerink MR. Radiology2021 12301(3):533-540http://www.ncbi.nlm.nih.gov/pubmed/34454031Neoadjuvant Yttrium-90 Transarterial Radioembolization with Resin Microspheres Prescribed Using the Medical Internal Radiation Dose Model for Intrahepatic Cholangiocarcinoma. J Vasc Interv Radiol. 2021 11; 32(11):1560-1568.Sarwar A, Ali A, Ljuboja D, Weinstein JL, Shenoy-Bhangle AS, Nasser IA, Morrow MK, Faintuch S, Curry MP, Bullock AJ, Ahmed M. J Vasc Interv Radiol2021 1132(11):1560-1568http://www.ncbi.nlm.nih.gov/pubmed/34297268Priming of Sorafenib Prior to Radiofrequency Ablation Does Not Increase Treatment Effect in Hepatocellular Carcinoma. Dig Dis Sci. 2022 07; 67(7):3455-3463.Bockorny B, Bullock AJ, Abrams TA, Faintuch S, Alsop DC, Goldberg SN, Ahmed M, Miksad RA. Dig Dis Sci2022 0767(7):3455-3463http://www.ncbi.nlm.nih.gov/pubmed/34102304Prostate Artery Embolization in 6 Patients Who Previously Underwent Failed Transurethral Interventions for Lower Urinary Tract Symptoms. J Vasc Interv Radiol. 2021 08; 32(8):1245-1247.Mehta SV, Veyg D, Lewis T, Faintuch S, Ahmed M. J Vasc Interv Radiol2021 0832(8):1245-1247http://www.ncbi.nlm.nih.gov/pubmed/33939974Time-Driven Activity-Based Costing in Interventional Oncology: Cost Measurement and Cost Variability for Hepatocellular Carcinoma Therapies. J Am Coll Radiol. 2021 Aug; 18(8):1095-1105.Ljuboja D, Ahmed M, Ali A, Perez E, Subrize MW, Kaplan RS, Sarwar A. J Am Coll Radiol2021 Aug18(8):1095-1105http://www.ncbi.nlm.nih.gov/pubmed/33901585In vivo detection of distal tumor glycolytic flux stimulated by hepatic ablation in a breast cancer model using hyperpolarized 13C MRI. Magn Reson Imaging. 2021 07; 80:90-97.Goodwin JS, Tsai LL, Mwin D, Coutinho de Souza P, Dialani S, Moon JT, Zhang Z, Grant AK, Ahmed M. Magn Reson Imaging2021 0780:90-97http://www.ncbi.nlm.nih.gov/pubmed/33905749Safely Shortening the Observation Time After CT-Guided Lung Procedures. J Am Coll Radiol. 2021 Aug; 18(8):1118-1127.Ah-Lan KC, Nakhaei M, Camacho A, Appel E, Siewert B, Ahmed M, Brook OR. J Am Coll Radiol2021 Aug18(8):1118-1127http://www.ncbi.nlm.nih.gov/pubmed/33703927Efficacy of TIPS Reduction for Refractory Hepatic Encephalopathy, Right Heart Failure, and Liver Dysfunction. AJR Am J Roentgenol. 2021 05; 216(5):1267-1272.Sarwar A, Esparaz AM, Chakrala N, Mangano M, Ganguli S, Malik R, Ahmed M. AJR Am J Roentgenol2021 05216(5):1267-1272http://www.ncbi.nlm.nih.gov/pubmed/33640082Transsplenic Arterial Embolization for Splenic Artery Steal Following Liver Transplant. J Vasc Interv Radiol. 2021 03; 32(3):474-475.Bulman JC, Weinstein JL, Moussa M, Ahmed M. J Vasc Interv Radiol2021 0332(3):474-475http://www.ncbi.nlm.nih.gov/pubmed/33612046Incomplete thermal ablation of tumors promotes increased tumorigenesis. Int J Hyperthermia. 2021; 38(1):263-272.Markezana A, Goldberg SN, Kumar G, Zorde-Khvalevsky E, Gourevtich S, Rozenblum N, Galun E, Ahmed M. Int J Hyperthermia202138(1):263-272http://www.ncbi.nlm.nih.gov/pubmed/33339678Analysis of Kinematic Differences in Hand Motion between Novice and Experienced Operators in IR: A Pilot Study. J Vasc Interv Radiol. 2021 02; 32(2):226-234.Weinstein JL, El-Gabalawy F, Sarwar A, DeBacker SS, Faintuch S, Berkowitz SJ, Bulman JC, Palmer MR, Matyal R, Mahmood F, Ahmed M. J Vasc Interv Radiol2021 0232(2):226-234http://www.ncbi.nlm.nih.gov/pubmed/33328709Percutaneous Thermal Ablation for Hepatocellular Carcinoma. Semin Intervent Radiol. 2020 Dec; 37(5):527-536.Weinstein JL, Ahmed M. Semin Intervent Radiol2020 Dec37(5):527-536http://www.ncbi.nlm.nih.gov/pubmed/33088374Extrahepatic transarterial radioembolization to treat fibrolamellar hepatocellular carcinoma: A case report. Radiol Case Rep. 2020 Dec; 15(12):2613-2616.Ljuboja D, Weinstein JL, Ahmed M, Sarwar A. Radiol Case Rep2020 Dec15(12):2613-2616http://www.ncbi.nlm.nih.gov/pubmed/32901301Yttrium-90 radioembolization using MIRD dosimetry with resin microspheres. Eur Radiol. 2021 Mar; 31(3):1316-1324.Sarwar A, Kudla A, Weinstein JL, Ali A, Malik R, Bullock A, Khwaja KO, Curry M, Faintuch S, Ahmed M. Eur Radiol2021 Mar31(3):1316-1324http://www.ncbi.nlm.nih.gov/pubmed/32620320Transitioning the IR Clinic to Telehealth: A Single-Center Experience during the COVID-19 Pandemic. J Vasc Interv Radiol. 2020 08; 31(8):1315-1319.e4.Bulman JC, Moussa M, Lewis TK, Berkowitz S, Sarwar A, Faintuch S, Ahmed M. J Vasc Interv Radiol2020 0831(8):1315-1319.e4http://www.ncbi.nlm.nih.gov/pubmed/32591892Dependent lesion positioning at CT-guided lung biopsy to reduce risk of pneumothorax. Eur Radiol. 2020 Nov; 30(11):6369-6375.Appel E, Dommaraju S, Camacho A, Nakhaei M, Siewert B, Ahmed M, Brook A, Brook OR. Eur Radiol2020 Nov30(11):6369-6375http://www.ncbi.nlm.nih.gov/pubmed/32374665Causes and Rates of 30-Day Readmissions After Transjugular Intrahepatic Portosystemic Shunts. AJR Am J Roentgenol. 2020 07; 215(1):235-241.Sarwar A, Weinstein JL, Novack V, Chakrala N, Tapper EB, Malik R, Ahmed M. AJR Am J Roentgenol2020 07215(1):235-241http://www.ncbi.nlm.nih.gov/pubmed/31969029Moderate hyperthermic heating encountered during thermal ablation increases tumor cell activity. Int J Hyperthermia. 2020; 37(1):119-129.Markezana A, Ahmed M, Kumar G, Zorde-Khvalevsky E, Rozenblum N, Galun E, Goldberg SN. Int J Hyperthermia202037(1):119-129http://www.ncbi.nlm.nih.gov/pubmed/31845846Thermal Ablation Induces Transitory Metastatic Growth by Means of the STAT3/c-Met Molecular Pathway in an Intrahepatic Colorectal Cancer Mouse Model. Radiology. 2020 02; 294(2):464-472.Liao H, Ahmed M, Markezana A, Zeng G, Stechele M, Galun E, Goldberg SN. Radiology2020 02294(2):464-472http://www.ncbi.nlm.nih.gov/pubmed/31409569Uterine Artery Embolization with Gelfoam for Acquired Symptomatic Uterine Arteriovenous Shunting. J Vasc Interv Radiol. 2019 Nov; 30(11):1750-1758.Camacho A, Ahn EH, Appel E, Boos J, Nguyen Q, Justaniah AI, Faintuch S, Ahmed M, Brook OR. J Vasc Interv Radiol2019 Nov30(11):1750-1758http://www.ncbi.nlm.nih.gov/pubmed/31349976Percutaneous Balloon Pericardiotomy and Indwelling Pericardial-Pleural Drain Placement for Refractory Malignant Pericardial Effusion. J Vasc Interv Radiol. 2019 Aug; 30(8):1208-1209.Schroeppel DeBacker SE, Sarwar A, Weinstein JL, Laham R, Ahmed M. J Vasc Interv Radiol2019 Aug30(8):1208-1209http://www.ncbi.nlm.nih.gov/pubmed/31012818Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper. Radiology. 2019 07; 292(1):25-34.Erinjeri JP, Fine GC, Adema GJ, Ahmed M, Chapiro J, den Brok M, Duran R, Hunt SJ, Johnson DT, Ricke J, Sze DY, Toskich BB, Wood BJ, Woodrum D, Goldberg SN. Radiology2019 07292(1):25-34http://www.ncbi.nlm.nih.gov/pubmed/31005490Transsplenic Catheter-Directed Thrombolysis for Early Portal Vein Thrombosis after Right Trisegmentectomy. J Vasc Interv Radiol. 2019 Oct; 30(10):1619-1622.Moon JT, Sarwar A, Khwaja KO, Soden PA, Moser AJ, Ahmed M. J Vasc Interv Radiol2019 Oct30(10):1619-1622http://www.ncbi.nlm.nih.gov/pubmed/30803397Image-Guided Thyroid Ablation: Proposal for Standardization of Terminology and Reporting Criteria. Thyroid. 2019 05; 29(5):611-618.Mauri G, Pacella CM, Papini E, Solbiati L, Goldberg SN, Ahmed M, Sconfienza LM. Thyroid2019 0529(5):611-618http://www.ncbi.nlm.nih.gov/pubmed/30824305Electronic IR Group Peer Review and Learning Performed during Daily Clinical Rounds. J Vasc Interv Radiol. 2019 Apr; 30(4):594-600.Luo M, Berkowitz S, Nguyen Q, Yam CS, Faintuch S, Ahmed M, Collares F, Sarwar A, Weinstein JL, Brook OR. J Vasc Interv Radiol2019 Apr30(4):594-600http://www.ncbi.nlm.nih.gov/pubmed/30599096Causes and Rates of 30-day Readmissions after Percutaneous Transhepatic Biliary Drainage Procedure. Radiology. 2019 03; 290(3):722-729.Sarwar A, Hostage CA, Weinstein JL, Kim G, Novack V, Chakrala N, Park Y, Brook OR, Ahmed M. Radiology2019 03290(3):722-729http://www.ncbi.nlm.nih.gov/pubmed/31179781Ultrasound-guided percutaneous microwave ablation of central intraductal papilloma: a prospective pilot study. Int J Hyperthermia. 2019; 36(1):606-612.Yu J, Wu H, Meng XW, Mu MJ, Dou JP, Ahmed M, Liang P. Int J Hyperthermia201936(1):606-612http://www.ncbi.nlm.nih.gov/pubmed/30303807Ongoing Professional Practice Evaluation of Radiologists: Strategies and Tools for Simplifying a Complex Process. Radiographics. 2018 10; 38(6):1593-1608.Kruskal JB, Eisenberg RL, Ahmed M, Siewert B. Radiographics2018 1038(6):1593-1608http://www.ncbi.nlm.nih.gov/pubmed/30359488Primary Stent Placement for Hepatic Artery Stenosis After Liver Transplantation: Improving Primary Patency and Reintervention Rates. Liver Transpl. 2018 10; 24(10):1377-1383.Sarwar A, Chen C, Khwaja K, Malik R, Raven KE, Weinstein JL, Evenson A, Faintuch S, Fisher R, Curry MP, Ahmed M. Liver Transpl2018 1024(10):1377-1383http://www.ncbi.nlm.nih.gov/pubmed/30017623Impact of Performing Nonurgent Interventional Radiology Procedures on Weekends. J Am Coll Radiol. 2018 Sep; 15(9):1246-1253.Ahmed M, Sarwar A, Hallett D, Guthrie M, O'Bryan B, Mehta S, Fudim T, Faintuch S. J Am Coll Radiol2018 Sep15(9):1246-1253http://www.ncbi.nlm.nih.gov/pubmed/29702018Percutaneous Ablation for Hepatocellular Carcinoma. AJR Am J Roentgenol. 2018 Jun; 210(6):1368-1375.Weinstein JL, Ahmed M. AJR Am J Roentgenol2018 Jun210(6):1368-1375http://www.ncbi.nlm.nih.gov/pubmed/29631466Radiofrequency ablation (RFA)-induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins. Int J Hyperthermia. 2018 11; 34(7):934-942.Ahmed M, Kumar G, Gourevitch S, Levchenko T, Galun E, Torchilin V, Goldberg SN. Int J Hyperthermia2018 1134(7):934-942http://www.ncbi.nlm.nih.gov/pubmed/29373245Structured Reporting of IR Procedures: Effect on Report Compliance, Accuracy, and Satisfaction. J Vasc Interv Radiol. 2018 03; 29(3):345-352.Nguyen Q, Sarwar A, Luo M, Berkowitz S, Ahmed M, Brook OR. J Vasc Interv Radiol2018 0329(3):345-352http://www.ncbi.nlm.nih.gov/pubmed/28681542Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States. Hepatology. 2018 02; 67(2):690-699.Sarwar A, Zhou L, Novack V, Tapper EB, Curry M, Malik R, Ahmed M. Hepatology2018 0267(2):690-699http://www.ncbi.nlm.nih.gov/pubmed/28975378Percutaneous Ultrasound-Guided Cryoablation for Symptomatic Plantar Fibromas. Cardiovasc Intervent Radiol. 2018 Feb; 41(2):298-304.Ahmed M, Weinstein JL, Hussain J, Sarwar A, Anderson M, Dillon B. Cardiovasc Intervent Radiol2018 Feb41(2):298-304http://www.ncbi.nlm.nih.gov/pubmed/28466184Thirty-day emergency room visits and hospital admissions after outpatient non-vascular image-guided procedures. Abdom Radiol (NY). 2017 10; 42(10):2538-2543.Nguyen Q, Mehta SV, Fang J, Sheiman R, Kane R, Ahmed M, Sarwar A, Siewert B, Brook OR. Abdom Radiol (NY)2017 1042(10):2538-2543http://www.ncbi.nlm.nih.gov/pubmed/28880787Targeting STAT3 to Suppress Systemic Pro-Oncogenic Effects from Hepatic Radiofrequency Ablation. Radiology. 2018 02; 286(2):524-536.Kumar G, Goldberg SN, Gourevitch S, Levchenko T, Torchilin V, Galun E, Ahmed M. Radiology2018 02286(2):524-536http://www.ncbi.nlm.nih.gov/pubmed/28779396Fluoroscopic percutaneous brush cytology, forceps biopsy and both in tandem for diagnosis of malignant biliary obstruction. Eur Radiol. 2018 Feb; 28(2):522-529.Boos J, Yoo RJ, Steinkeler J, Ayata G, Ahmed M, Sarwar A, Weinstein J, Faintuch S, Brook OR. Eur Radiol2018 Feb28(2):522-529http://www.ncbi.nlm.nih.gov/pubmed/28263243Use of 3-Dimensional Printing to Create Patient-Specific Thoracic Spine Models as Task Trainers. Reg Anesth Pain Med. 2017 Jul/Aug; 42(4):469-474.Jeganathan J, Baribeau Y, Bortman J, Mahmood F, Shnider M, Ahmed M, Mashari A, Amir R, Amador Y, Matyal R. Reg Anesth Pain Med2017 Jul/Aug42(4):469-474http://www.ncbi.nlm.nih.gov/pubmed/28422778Ultrasound as a Screening Tool for Central Venous Catheter Positioning and Exclusion of Pneumothorax. Crit Care Med. 2017 Jul; 45(7):1192-1198.Amir R, Knio ZO, Mahmood F, Oren-Grinberg A, Leibowitz A, Bose R, Shaefi S, Mitchell JD, Ahmed M, Bardia A, Talmor D, Matyal R. Crit Care Med2017 Jul45(7):1192-1198http://www.ncbi.nlm.nih.gov/pubmed/28097389Observation time after outpatient non-arterial interventional procedures: standards, safety, and outcomes. Abdom Radiol (NY). 2017 05; 42(5):1571-1578.Chen CK, Boos J, Sarwar A, O'Bryan-Alberts B, Ahmed M, Brook OR. Abdom Radiol (NY)2017 0542(5):1571-1578http://www.ncbi.nlm.nih.gov/pubmed/27853849Measuring and improving the patient experience in radiology. Abdom Radiol (NY). 2017 04; 42(4):1259-1267.Brook OR, Siewert B, Weinstein J, Ahmed M, Kruskal J. Abdom Radiol (NY)2017 0442(4):1259-1267http://www.ncbi.nlm.nih.gov/pubmed/28291716The Relevance of Readmissions after Common IR Procedures: Readmission Rates and Association with Early Mortality. J Vasc Interv Radiol. 2017 May; 28(5):629-636.Sarwar A, Zhou L, Chakrala N, Brook OR, Weinstein JL, Rosen MP, Ahmed M. J Vasc Interv Radiol2017 May28(5):629-636http://www.ncbi.nlm.nih.gov/pubmed/28175974Resolution of Metallic Biliary Stent Allergic Reaction After Partial Stent Removal in a Patient with Nickel Sensitivity. Cardiovasc Intervent Radiol. 2017 Jul; 40(7):1118-1122.Esparaz AM, Ahmed M. Cardiovasc Intervent Radiol2017 Jul40(7):1118-1122http://www.ncbi.nlm.nih.gov/pubmed/27959638Comparison of Vascular Plugs and Pushable Coils for Variceal Embolization After TIPS. AJR Am J Roentgenol. 2017 Mar; 208(3):650-655.Sarwar A, Esparaz AM, Tapper EB, Brook OR, Grunwald D, Malik R, Ahmed M. AJR Am J Roentgenol2017 Mar208(3):650-655http://www.ncbi.nlm.nih.gov/pubmed/27600101Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies. 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J Pak Med Assoc2000 Jul50(7):215-6Catheter Ablation504.906843135416422e+0002002-03-01T00:00:002023-09-28T00:00:00Portasystemic Shunt, Transjugular Intrahepatic83.848095491848389e+0002016-01-01T00:00:002023-05-12T00:00:00Liver Neoplasms313.419470018813820e+0002002-07-01T00:00:002025-09-26T00:00:00Radiography, Interventional133.341219070816468e+0002011-02-01T00:00:002025-07-06T00:00:00Radiology, Interventional133.088548336019588e+0002014-10-23T00:00:002025-05-26T00:00:00Carcinoma, Hepatocellular232.770444187777033e+0002002-07-01T00:00:002025-08-05T00:00:00Embolization, Therapeutic112.766044098329267e+0002016-05-05T00:00:002025-11-11T00:00:00Yttrium Radioisotopes72.491951126127573e+0002020-09-08T00:00:002025-11-11T00:00:00Mammary Neoplasms, Experimental172.395880079941169e+0002002-03-01T00:00:002018-04-24T00:00:00Ablation Techniques112.319792969919210e+0002011-04-01T00:00:002025-09-26T00:00:00Cryosurgery52.077663223444052e+0002002-11-01T00:00:002024-07-02T00:00:00Portal Vein72.023629554626995e+0002002-09-01T00:00:002025-07-06T00:00:00Doxorubicin181.913334924467736e+0002002-03-01T00:00:002016-09-06T00:00:00Microspheres61.906634265693610e+0002020-09-08T00:00:002025-11-11T00:00:00Radiofrequency Ablation71.898735496865774e+0002018-04-24T00:00:002025-07-18T00:00:00Chemoembolization, Therapeutic61.794527574329180e+0002002-11-01T00:00:002023-03-24T00:00:00Hyperthermia, Induced111.774922588117626e+0002001-04-01T00:00:002023-09-28T00:00:00Catheterization, Central Venous51.612992141866837e+0002017-07-01T00:00:002025-05-23T00:00:00Hepatic Artery41.612626516486821e+0002012-01-01T00:00:002025-06-16T00:00:00Hepatectomy31.512810263487560e+0002016-05-05T00:00:002025-07-06T00:00:00Antibiotics, Antineoplastic61.503049045510461e+0002003-10-01T00:00:002016-09-06T00:00:00Bile Duct Neoplasms51.455736069318356e+0002017-08-04T00:00:002025-11-11T00:00:00Liver Transplantation71.387338050381435e+0002012-01-01T00:00:002025-06-16T00:00:00Hand51.370391443057774e+0002020-12-16T00:00:002025-05-23T00:00:00Ultrasonography, Interventional101.328415684434275e+0002012-10-22T00:00:002024-09-18T00:00:00Hepatic Encephalopathy21.314248385879001e+0002021-03-11T00:00:002022-08-17T00:00:00Rats, Inbred F344201.272267466737287e+0002002-03-01T00:00:002024-03-01T00:00:00Venous Thrombosis61.251832446779658e+0002002-09-01T00:00:002023-05-12T00:00:00Esophageal and Gastric Varices31.236620052687414e+0002016-12-13T00:00:002023-05-12T00:00:00Liver201.231129257020715e+0002001-04-01T00:00:002024-03-14T00:00:00Radiologists41.099466075397912e+0002018-10-01T00:00:002022-01-20T00:00:00Cholangiocarcinoma39.965058055618717e-0012019-04-17T00:00:002025-11-11T00:00:00Clinical Competence89.772905817605464e-0012017-04-01T00:00:002025-05-23T00:00:00Catheterization, Peripheral29.702679895539768e-0012019-04-17T00:00:002020-12-16T00:00:00End Stage Liver Disease29.620145111533085e-0012018-10-01T00:00:002022-12-07T00:00:00Liposomes138.768795854331397e-0012002-03-01T00:00:002023-10-26T00:00:00Liver Neoplasms, Experimental48.744209675487586e-0012016-01-18T00:00:002019-12-17T00:00:00Electromagnetic Phenomena28.219027893160080e-0012020-12-16T00:00:002025-01-01T00:00:00Surgery, Computer-Assisted68.198323222776178e-0012007-01-23T00:00:002019-04-12T00:00:00Neoplasms, Multiple Primary27.853748919930338e-0012005-05-01T00:00:002023-10-26T00:00:00Stents57.812066734982561e-0012017-02-07T00:00:002025-06-16T00:00:00Evoked Potentials, Somatosensory17.696177887750308e-0012024-07-02T00:00:002024-07-02T00:00:00Intraoperative Neurophysiological Monitoring17.537275355676887e-0012024-07-02T00:00:002024-07-02T00:00:00Microwaves37.477544812538248e-0012016-07-13T00:00:002025-09-26T00:00:00Adenocarcinoma107.279325905998672e-0012002-09-01T00:00:002021-01-01T00:00:00Image-Guided Biopsy77.141189730191386e-0012017-08-04T00:00:002024-03-14T00:00:00Peripheral Nerve Injuries16.962392416653821e-0012024-07-02T00:00:002024-07-02T00:00:00Chemotherapy, Adjuvant136.892810962705905e-0012002-07-01T00:00:002017-09-06T00:00:00Needles26.848729500293809e-0012020-06-27T00:00:002024-06-27T00:00:00Evoked Potentials, Motor16.746732279661892e-0012024-07-02T00:00:002024-07-02T00:00:00Quercetin46.727798853305872e-0012011-01-01T00:00:002016-09-06T00:00:00Splenic Artery16.701052092644356e-0012021-03-01T00:00:002021-03-01T00:00:00Transurethral Resection of Prostate16.609312094963793e-0012021-06-05T00:00:002021-06-05T00:00:00Patient Readmission36.423947631828704e-0012017-03-11T00:00:002020-05-06T00:00:00Lower Urinary Tract Symptoms16.378130531745716e-0012021-06-05T00:00:002021-06-05T00:00:00Granulocyte-Macrophage Colony-Stimulating Factor16.372666080283032e-0012023-10-26T00:00:002023-10-26T00:00:00Treatment Outcome436.199455635678588e-0012000-07-01T00:00:002025-11-11T00:00:00Venereal Tumors, Veterinary36.130846063776181e-0012002-07-01T00:00:002004-03-01T00:00:00Splenic Vein16.106797782351237e-0012019-04-17T00:00:002019-04-17T00:00:00Neoplasms146.059413848028618e-0012004-11-01T00:00:002021-09-28T00:00:00Pericardiectomy15.962387589894028e-0012019-08-01T00:00:002019-08-01T00:00:00Cholangitis, Sclerosing15.770959312118241e-0012021-03-01T00:00:002021-03-01T00:00:00Radial Artery15.711563470425958e-0012020-12-16T00:00:002020-12-16T00:00:00Retrospective Studies525.645353147372503e-0012000-07-01T00:00:002025-11-11T00:00:00Postoperative Complications65.611718776958915e-0012012-10-22T00:00:002025-06-16T00:00:00Motor Skills15.355015357433749e-0012020-12-16T00:00:002020-12-16T00:00:00Catheters25.348111372645612e-0012019-08-01T00:00:002022-03-14T00:00:00Terminology as Topic35.306334207240331e-0012014-06-13T00:00:002019-04-12T00:00:00Prostatic Hyperplasia15.297544139789069e-0012021-06-05T00:00:002021-06-05T00:00:00Heat-Shock Proteins45.290384586046705e-0012010-09-21T00:00:002018-04-24T00:00:00After-Hours Care15.263658759743762e-0012018-07-14T00:00:002018-07-14T00:00:00Drainage35.249960578917240e-0012019-01-01T00:00:002022-03-14T00:00:00Common Bile Duct Diseases15.219658644995895e-0012017-02-07T00:00:002017-02-07T00:00:00Cholestasis, Extrahepatic15.209434811040231e-0012017-02-07T00:00:002017-02-07T00:00:00Rats235.150298507906957e-0012002-03-01T00:00:002024-03-01T00:00:00Pericardial Effusion15.140179256172691e-0012019-08-01T00:00:002019-08-01T00:00:00HSP70 Heat-Shock Proteins35.126496866587033e-0012010-02-16T00:00:002016-09-06T00:00:00STAT3 Transcription Factor25.107826121194454e-0012017-09-06T00:00:002019-12-17T00:00:00Health Literacy15.020745066582131e-0012023-06-16T00:00:002023-06-16T00:00:00Foot Diseases14.917091737387066e-0012017-10-03T00:00:002017-10-03T00:00:00Necrosis84.897885732669787e-0012002-03-01T00:00:002025-08-05T00:00:00Nickel14.896689746422615e-0012017-02-07T00:00:002017-02-07T00:00:00Graft Occlusion, Vascular24.891867623148673e-0012018-10-01T00:00:002022-05-17T00:00:00Neoplasm Seeding14.860478362162049e-0012016-07-13T00:00:002016-07-13T00:00:00Ampulla of Vater14.827767380376677e-0012017-02-07T00:00:002017-02-07T00:00:00Fibroma14.751976420424981e-0012017-10-03T00:00:002017-10-03T00:00:00Humans1144.678623389882136e-0012000-07-01T00:00:002025-11-11T00:00:00Nanoparticles34.620496417124031e-0012014-08-18T00:00:002016-09-06T00:00:00Celecoxib14.527597723447442e-0012016-06-10T00:00:002016-06-10T00:00:00Sarcoma, Experimental24.374162273419171e-0012004-03-01T00:00:002005-05-01T00:00:00Gastrointestinal Hemorrhage34.353312403454847e-0012016-12-13T00:00:002023-05-12T00:00:00Angioplasty, Balloon14.244733801080975e-0012018-10-01T00:00:002018-10-01T00:00:00Middle Aged544.222904836182856e-0012000-07-01T00:00:002025-11-11T00:00:00Electric Conductivity64.194330664682153e-0012001-04-01T00:00:002013-10-28T00:00:00Cyclooxygenase 2 Inhibitors14.183782670188065e-0012016-06-10T00:00:002016-06-10T00:00:00Hepatocyte Growth Factor44.178406907653746e-0012015-09-29T00:00:002022-07-20T00:00:00Kidney Neoplasms54.112801220934027e-0012004-03-01T00:00:002019-08-01T00:00:00Male644.112717645042270e-0012000-11-01T00:00:002025-11-11T00:00:00Telemedicine24.098688948516104e-0012020-06-30T00:00:002022-11-19T00:00:00Angioplasty13.971031036976970e-0012016-05-05T00:00:002016-05-05T00:00:00Female773.964754527065720e-0012000-11-01T00:00:002025-11-11T00:00:00Device Removal23.934116085552678e-0012017-02-07T00:00:002023-12-22T00:00:00Electroporation43.919657071029905e-0012012-11-20T00:00:002016-01-27T00:00:00Sulfones13.876665159231595e-0012015-09-29T00:00:002015-09-29T00:00:00Internship and Residency53.830427290910391e-0012021-11-30T00:00:002025-05-26T00:00:00Microvessels23.803482767654767e-0012013-05-09T00:00:002017-09-06T00:00:00Liver Diseases13.710659260417901e-0012021-03-11T00:00:002021-03-11T00:00:00Vascular Patency43.668366752246550e-0012018-10-01T00:00:002025-06-16T00:00:00Pneumothorax33.645427463975475e-0012017-07-01T00:00:002021-04-24T00:00:00Combined Modality Therapy163.634149595946395e-0012002-03-01T00:00:002018-04-27T00:00:00Feasibility Studies53.410900439589046e-0012002-09-01T00:00:002023-10-06T00:00:00Carcinogenesis53.406084940189025e-0012017-09-06T00:00:002023-09-28T00:00:00Animals503.321448263032668e-0012001-04-01T00:00:002024-03-01T00:00:00Boronic Acids13.300832077366483e-0012014-10-16T00:00:002014-10-16T00:00:00Micelles33.292297669801998e-0012014-08-18T00:00:002016-09-06T00:00:00Hypoxia-Inducible Factor 1, alpha Subunit13.278925339776582e-0012014-10-16T00:00:002014-10-16T00:00:00Thrombolytic Therapy13.234331841011683e-0012019-04-17T00:00:002019-04-17T00:00:00Thermal Conductivity23.129411017373440e-0012006-06-01T00:00:002008-11-01T00:00:00Up-Regulation23.069968193461278e-0012014-10-16T00:00:002017-09-06T00:00:00Phantoms, Imaging43.038909330519361e-0012005-08-01T00:00:002025-05-23T00:00:00Neoplasm Transplantation63.018074787699449e-0012002-03-01T00:00:002017-09-06T00:00:00Aged362.973211895381439e-0012002-07-01T00:00:002025-11-11T00:00:00Physicians22.893407593918495e-0012023-09-02T00:00:002023-12-22T00:00:00Pyrazines12.888217701251967e-0012014-10-16T00:00:002014-10-16T00:00:00Thrombosis12.877179604652713e-0012022-12-12T00:00:002022-12-12T00:00:00Ventricular Function, Left12.870921121607041e-0012022-02-16T00:00:002022-02-16T00:00:00Research Design22.848102773141547e-0012014-06-13T00:00:002014-10-23T00:00:00Varicose Veins22.842889550550306e-0012016-12-13T00:00:002023-05-12T00:00:00Liver Diseases, Parasitic12.839018568730681e-0012008-03-01T00:00:002008-03-01T00:00:00Disease Models, Animal132.837898982074693e-0012003-07-01T00:00:002023-10-26T00:00:00Neoplasm Recurrence, Local52.798099878432618e-0012012-01-01T00:00:002025-06-28T00:00:00Patient Care Planning12.761650771673311e-0012013-12-01T00:00:002013-12-01T00:00:00Time Factors202.736171818700677e-0012002-07-01T00:00:002025-09-26T00:00:00Antineoplastic Agents112.710509613570731e-0012002-03-01T00:00:002015-07-08T00:00:00Vascular Endothelial Growth Factor A52.668643423468600e-0012015-07-08T00:00:002022-07-20T00:00:00Hypersensitivity12.667480962555450e-0012017-02-07T00:00:002017-02-07T00:00:00Liver Cirrhosis32.653373612952928e-0012008-03-01T00:00:002022-02-16T00:00:00Splenic Diseases12.651252882857479e-0012008-03-01T00:00:002008-03-01T00:00:00Schistosomiasis12.639546689136273e-0012008-03-01T00:00:002008-03-01T00:00:00Heart Failure22.597087080946947e-0012021-03-11T00:00:002022-02-16T00:00:00Hyperaldosteronism22.589170834049389e-0012016-05-27T00:00:002025-07-18T00:00:00Betacoronavirus12.573838156783088e-0012020-06-30T00:00:002020-06-30T00:00:00Indoles12.544277575952360e-0012015-09-29T00:00:002015-09-29T00:00:00RNA, Small Interfering12.453127043268984e-0012015-07-08T00:00:002015-07-08T00:00:00Tomography, Spiral Computed22.446615953333825e-0012003-07-01T00:00:002005-05-01T00:00:00Carcinoma, Renal Cell22.373682205989727e-0012012-08-21T00:00:002019-08-01T00:00:00Inflammation22.369833368679209e-0012016-06-10T00:00:002016-07-13T00:00:00Soft Tissue Neoplasms22.325266296645807e-0012004-03-01T00:00:002005-05-01T00:00:00Positron Emission Tomography Computed Tomography22.313617163027598e-0012024-05-01T00:00:002025-06-28T00:00:00Mortality12.307414317203832e-0012017-03-11T00:00:002017-03-11T00:00:00Saline Solution, Hypertonic22.205821038468830e-0012001-04-01T00:00:002002-07-01T00:00:00Tomography, X-Ray Computed142.198963730823064e-0012002-07-01T00:00:002025-09-26T00:00:00Splenomegaly12.159952506523964e-0012005-05-01T00:00:002005-05-01T00:00:00Prostate22.097675034963551e-0012021-06-05T00:00:002023-09-02T00:00:00Ambulatory Care32.085394801005405e-0012017-05-01T00:00:002022-11-19T00:00:00Wireless Technology12.062003365946175e-0012025-01-01T00:00:002025-01-01T00:00:00Liver Regeneration12.045696969379270e-0012025-07-06T00:00:002025-07-06T00:00:00Acetic Acid12.020603456754495e-0012003-08-01T00:00:002003-08-01T00:00:00Coronavirus Infections11.948263042143013e-0012020-06-30T00:00:002020-06-30T00:00:00Pneumonia, Viral11.928044938797990e-0012020-06-30T00:00:002020-06-30T00:00:00Adult291.898908544529036e-0012000-07-01T00:00:002025-07-18T00:00:00Shift Work Schedule11.873000236550478e-0012025-05-26T00:00:002025-05-26T00:00:00International Normalized Ratio11.846550915018930e-0012024-03-14T00:00:002024-03-14T00:00:00Dog Diseases11.831641839412434e-0012003-08-01T00:00:002003-08-01T00:00:00Pelvis21.811083531379217e-0012023-09-02T00:00:002023-09-14T00:00:00Margins of Excision11.805419990790170e-0012025-09-26T00:00:002025-09-26T00:00:00Aneurysm, False11.804673640108547e-0012024-09-18T00:00:002024-09-18T00:00:00Granulocytes11.782444034137881e-0012023-10-26T00:00:002023-10-26T00:00:00Thrombin11.772715714260705e-0012024-09-18T00:00:002024-09-18T00:00:00Suction11.770305746585617e-0012022-12-12T00:00:002022-12-12T00:00:00Movement21.752714885203352e-0012025-01-01T00:00:002025-05-23T00:00:00Vena Cava Filters11.741499606887077e-0012023-12-22T00:00:002023-12-22T00:00:00Hemostatic Techniques11.731213972888814e-0012002-07-01T00:00:002002-07-01T00:00:00Colorectal Neoplasms51.721007240659102e-0012012-10-22T00:00:002025-09-26T00:00:00Kidney51.712478530309210e-0012004-03-01T00:00:002015-07-08T00:00:00Prostatic Neoplasms11.666211946919320e-0012023-10-06T00:00:002023-10-06T00:00:00Thrombectomy21.642033737351635e-0012022-12-12T00:00:002023-05-12T00:00:00Simulation Training21.639079149817568e-0012024-06-27T00:00:002024-08-19T00:00:00Pandemics11.635098680076662e-0012020-06-30T00:00:002020-06-30T00:00:00Arterial Occlusive Diseases11.632602009657904e-0012024-11-23T00:00:002024-11-23T00:00:00Myofibroblasts11.619595757472656e-0012022-07-20T00:00:002022-07-20T00:00:00Subcutaneous Tissue21.595708617798298e-0012004-03-01T00:00:002015-07-08T00:00:00Risk Factors141.592825014805918e-0012000-11-01T00:00:002025-06-28T00:00:00Lymph Nodes31.588835749126923e-0012012-08-21T00:00:002024-07-02T00:00:00Tonsillectomy21.581565522676661e-0012000-07-01T00:00:002000-11-01T00:00:00Bile Ducts, Intrahepatic11.571384603572271e-0012021-08-25T00:00:002021-08-25T00:00:00Polyethylene Glycols31.564842848591861e-0012002-03-01T00:00:002016-09-06T00:00:00Electrocoagulation11.545384701727833e-0012000-07-01T00:00:002000-07-01T00:00:00Constriction, Pathologic21.539695493147158e-0012018-10-01T00:00:002024-11-23T00:00:00Breast Neoplasms31.532558144291680e-0012013-05-09T00:00:002023-07-04T00:00:00Gelatin Sponge, Absorbable11.531782897874928e-0012019-08-10T00:00:002019-08-10T00:00:00Patient Satisfaction31.531038612855945e-0012017-04-01T00:00:002023-09-09T00:00:00Consensus31.514185400574807e-0012019-02-27T00:00:002023-07-04T00:00:00Heating11.503023773857895e-0012020-01-01T00:00:002020-01-01T00:00:00Cell Proliferation41.501513509321194e-0012015-07-08T00:00:002022-09-24T00:00:00Atorvastatin11.492604149332845e-0012022-07-20T00:00:002022-07-20T00:00:00Punctures11.492248005703885e-0012020-12-16T00:00:002020-12-16T00:00:00ROC Curve21.475969348745871e-0012017-08-04T00:00:002025-05-23T00:00:00Uterine Artery Embolization11.475748252377566e-0012019-08-10T00:00:002019-08-10T00:00:00Living Donors11.472184129910341e-0012023-08-28T00:00:002023-08-28T00:00:00Upper Extremity11.464039028655056e-0012024-09-18T00:00:002024-09-18T00:00:00Lymphatic Vessels11.463032414762447e-0012023-11-20T00:00:002023-11-20T00:00:00Cone-Beam Computed Tomography11.448987144711595e-0012023-08-28T00:00:002023-08-28T00:00:00Peer Review, Health Care11.441288324509672e-0012019-02-27T00:00:002019-02-27T00:00:00Tertiary Care Centers11.441054523336433e-0012024-09-18T00:00:002024-09-18T00:00:00Ascites21.438443354642897e-0012016-01-01T00:00:002023-05-12T00:00:00Cholangiography11.437001231439740e-0012019-01-01T00:00:002019-01-01T00:00:00Dissection11.423166934572915e-0012000-07-01T00:00:002000-07-01T00:00:00Mice, Inbred C57BL71.423086522637595e-0012015-07-08T00:00:002023-06-20T00:00:00Abscess11.412385432797008e-0012022-03-14T00:00:002022-03-14T00:00:00Radiopharmaceuticals21.399984006794848e-0012025-01-14T00:00:002025-06-28T00:00:00Employee Performance Appraisal11.391161259284970e-0012018-10-01T00:00:002018-10-01T00:00:00Angiography11.386444093820875e-0012023-08-28T00:00:002023-08-28T00:00:00Arteriovenous Shunt, Surgical11.377845278499350e-0012022-05-17T00:00:002022-05-17T00:00:00Aminosalicylic Acids11.364184825564153e-0012017-09-06T00:00:002017-09-06T00:00:00Uterine Hemorrhage11.356970583498042e-0012019-08-10T00:00:002019-08-10T00:00:00Magnetic Resonance Imaging81.342891645803064e-0012008-03-01T00:00:002025-05-24T00:00:00Neoplasm Metastasis31.302528889779226e-0012012-08-21T00:00:002017-09-06T00:00:00Macrophages31.289135512742239e-0012016-07-13T00:00:002023-10-26T00:00:00Intention to Treat Analysis11.283791239841660e-0012018-07-14T00:00:002018-07-14T00:00:00Abdomen11.280841308415560e-0012023-09-14T00:00:002023-09-14T00:00:00Hot Temperature51.280652628640192e-0012004-01-01T00:00:002016-01-18T00:00:00Lymphedema11.277062022652254e-0012023-11-20T00:00:002023-11-20T00:00:00Predictive Value of Tests51.276129641532924e-0012012-08-21T00:00:002025-07-18T00:00:00Centers for Medicare and Medicaid Services, U.S.11.276105094693262e-0012020-06-30T00:00:002020-06-30T00:00:00Patch Tests11.271251454830892e-0012017-02-07T00:00:002017-02-07T00:00:00Benzenesulfonates11.269602251766028e-0012017-09-06T00:00:002017-09-06T00:00:00Time-to-Treatment11.261656381128891e-0012024-11-23T00:00:002024-11-23T00:00:00Aldosterone21.243832370363525e-0012016-05-27T00:00:002025-07-18T00:00:00Professional Practice11.242979506482680e-0012018-10-01T00:00:002018-10-01T00:00:00Angiography, Digital Subtraction11.241507983047586e-0012018-10-01T00:00:002018-10-01T00:00:00Length of Stay41.240139171141704e-0012016-01-01T00:00:002018-07-14T00:00:00Arteries11.237045007788197e-0012021-06-05T00:00:002021-06-05T00:00:00Neoplasms, Connective Tissue11.226241428339423e-0012016-07-13T00:00:002016-07-13T00:00:00Mice101.225606125351218e-0012013-05-09T00:00:002023-09-28T00:00:00Forkhead Transcription Factors11.209999857322796e-0012023-10-26T00:00:002023-10-26T00:00:00Minimally Invasive Surgical Procedures21.209695322325752e-0012011-02-01T00:00:002013-12-01T00:00:00Equipment Failure Analysis21.201909287434904e-0012007-01-23T00:00:002016-12-13T00:00:00Interleukin-621.188827609111027e-0012015-07-08T00:00:002016-07-13T00:00:00Societies, Medical31.187763148617774e-0012019-04-23T00:00:002023-06-16T00:00:00Tumor Burden21.186317046014030e-0012016-07-13T00:00:002025-06-28T00:00:00Radiation Dosage21.184524492469890e-0012003-07-01T00:00:002021-08-25T00:00:00Mentoring11.176681920424428e-0012022-02-01T00:00:002022-02-01T00:00:00Hospitals, Low-Volume11.167863114874044e-0012017-12-27T00:00:002017-12-27T00:00:00Postpartum Hemorrhage11.163310465652432e-0012019-08-10T00:00:002019-08-10T00:00:00Lung Neoplasms41.146403372939757e-0012004-03-01T00:00:002023-10-20T00:00:00Dogs41.142917242960684e-0012002-07-01T00:00:002004-03-01T00:00:00Xenograft Model Antitumor Assays21.124909947666326e-0012013-05-09T00:00:002014-08-18T00:00:00Checklist11.116445785870028e-0012022-07-05T00:00:002022-07-05T00:00:00Outpatients11.110549667583553e-0012022-11-19T00:00:002022-11-19T00:00:00Decision Support Techniques11.107539619972361e-0012025-07-18T00:00:002025-07-18T00:00:00Fatal Outcome11.099058942597979e-0012019-08-01T00:00:002019-08-01T00:00:00Teaching Rounds11.091895705068101e-0012019-02-27T00:00:002019-02-27T00:00:00Syndrome11.088507425268694e-0012021-03-01T00:00:002021-03-01T00:00:00Radiology Department, Hospital11.086151955221128e-0012018-10-01T00:00:002018-10-01T00:00:00Hospitals, High-Volume11.071524700413676e-0012017-12-27T00:00:002017-12-27T00:00:00Vinblastine11.070845992722504e-0012016-01-18T00:00:002016-01-18T00:00:00Adrenal Cortex Neoplasms11.069207989700505e-0012016-05-27T00:00:002016-05-27T00:00:00Prospective Studies81.064385722314234e-0012017-07-01T00:00:002025-09-26T00:00:00Hypertrophy11.061185242106521e-0012016-05-05T00:00:002016-05-05T00:00:00Ki-67 Antigen11.050377950984284e-0012016-07-13T00:00:002016-07-13T00:00:00Hospital Mortality21.047256224500123e-0012017-12-27T00:00:002018-07-14T00:00:00Analgesia, Epidural11.045767365937105e-0012017-07-01T00:00:002017-07-01T00:00:00Radio Waves11.040023057418590e-0012015-09-29T00:00:002015-09-29T00:00:00Cholestasis11.034242632349504e-0012017-08-04T00:00:002017-08-04T00:00:00Severity of Illness Index21.030945599920534e-0012021-03-11T00:00:002022-12-07T00:00:00Adrenalectomy11.030880023476057e-0012016-05-27T00:00:002016-05-27T00:00:00Prostate-Specific Antigen11.030094172571302e-0012023-10-06T00:00:002023-10-06T00:00:00Imaging, Three-Dimensional31.011537304376765e-0012003-07-01T00:00:002025-09-26T00:00:00Random Allocation21.004431114285679e-0012003-07-01T00:00:002016-07-13T00:00:00Paraspinal Muscles11.003966124523326e-0012013-10-28T00:00:002013-10-28T00:00:00Radiology Information Systems11.002364955829596e-0012018-03-01T00:00:002018-03-01T00:00:00Oncogene Proteins11.001833764919489e-0012017-09-06T00:00:002017-09-06T00:00:00Models, Anatomic19.958025102656706e-0022017-07-01T00:00:002017-07-01T00:00:00Foot19.914558152449637e-0022017-10-03T00:00:002017-10-03T00:00:00Allografts19.869756162192983e-0022018-10-01T00:00:002018-10-01T00:00:00Biomechanical Phenomena19.866315933113899e-0022020-12-16T00:00:002020-12-16T00:00:00Fluoroscopy19.815104487957567e-0022017-08-04T00:00:002017-08-04T00:00:00May-Thurner Syndrome19.650325184559637e-0022012-12-01T00:00:002012-12-01T00:00:00Equipment Design49.572217333843407e-0022002-09-01T00:00:002016-12-13T00:00:00Patient Education as Topic19.434140049991939e-0022023-06-16T00:00:002023-06-16T00:00:00Thoracic Vertebrae19.414009525901802e-0022017-07-01T00:00:002017-07-01T00:00:00Renal Dialysis19.413656457182147e-0022022-05-17T00:00:002022-05-17T00:00:00Models, Theoretical39.409473349324973e-0022004-01-01T00:00:002019-01-01T00:00:00Postoperative Hemorrhage19.361451182728614e-0022016-08-11T00:00:002016-08-11T00:00:00Pancreaticoduodenectomy19.341087361689147e-0022016-08-11T00:00:002016-08-11T00:00:00Dendritic Cells19.049780830767178e-0022023-10-26T00:00:002023-10-26T00:00:00Printing, Three-Dimensional18.951958022196879e-0022017-07-01T00:00:002017-07-01T00:00:00Antineoplastic Agents, Phytogenic18.944610713534801e-0022016-01-18T00:00:002016-01-18T00:00:00Electrodes38.930513708878576e-0022007-01-23T00:00:002012-11-20T00:00:00Aged, 80 and over118.844114898237673e-0022002-07-01T00:00:002024-09-18T00:00:00Thyroid Nodule18.827670896378793e-0022019-04-12T00:00:002019-04-12T00:00:00Echocardiography28.623449998368768e-0022017-07-01T00:00:002022-02-16T00:00:00Reproducibility of Results38.486924590217984e-0022021-09-28T00:00:002025-07-18T00:00:00Computer Simulation48.476809475489164e-0022005-08-01T00:00:002008-11-01T00:00:00Documentation18.472592953935171e-0022018-03-01T00:00:002018-03-01T00:00:00Radiometry38.461319183340293e-0022003-07-01T00:00:002025-06-28T00:00:00Administration, Intravenous18.457725744195231e-0022013-05-09T00:00:002013-05-09T00:00:00Sarcoma18.447156488589967e-0022002-07-01T00:00:002002-07-01T00:00:00Lung48.335968742741075e-0022004-03-01T00:00:002023-10-20T00:00:00Pilot Projects38.239124234585281e-0022002-07-01T00:00:002020-12-16T00:00:00Algorithms48.224792827213731e-0022007-01-23T00:00:002025-05-24T00:00:00Bortezomib18.101791716962715e-0022014-10-16T00:00:002014-10-16T00:00:00Down-Regulation18.087173350087819e-0022017-09-06T00:00:002017-09-06T00:00:00Particle Size17.975775292437039e-0022014-08-18T00:00:002014-08-18T00:00:00Endovascular Procedures17.858388109273364e-0022024-11-23T00:00:002024-11-23T00:00:00Mental Health17.834614288321820e-0022025-05-26T00:00:002025-05-26T00:00:00Ultrasonography17.804484483061129e-0022023-05-13T00:00:002023-05-13T00:00:00Medical History Taking17.790175461797368e-0022013-12-01T00:00:002013-12-01T00:00:00Neoadjuvant Therapy17.765793688196956e-0022021-08-25T00:00:002021-08-25T00:00:00Muscle, Skeletal17.741931000111441e-0022005-05-01T00:00:002005-05-01T00:00:00Learning17.523460243820812e-0022019-02-27T00:00:002019-02-27T00:00:00Cell Line, Tumor37.490414198886773e-0022011-12-30T00:00:002016-09-06T00:00:00Swine77.481931079675655e-0022001-04-01T00:00:002016-07-25T00:00:00Software17.361182921655674e-0022023-06-16T00:00:002023-06-16T00:00:00Chi-Square Distribution37.330327962276281e-0022005-05-01T00:00:002016-08-11T00:00:00Boston27.204894923394113e-0022016-05-27T00:00:002019-01-01T00:00:00Pulmonary Blastoma16.990853456728732e-0022008-06-01T00:00:002008-06-01T00:00:00Young Adult56.929456001092069e-0022016-03-14T00:00:002022-12-12T00:00:00Students, Medical16.900420064182404e-0022021-11-30T00:00:002021-11-30T00:00:00Hepatocytes16.860903369651204e-0022015-07-08T00:00:002015-07-08T00:00:00Cell Transformation, Neoplastic16.781884295525097e-0022017-09-06T00:00:002017-09-06T00:00:00Injections, Intravenous36.743916394957948e-0022002-09-01T00:00:002004-11-01T00:00:00Recurrence16.716462276025915e-0022020-05-06T00:00:002020-05-06T00:00:00Graft Survival16.707523773318969e-0022018-10-01T00:00:002018-10-01T00:00:00Physical Examination16.674054279930307e-0022013-12-01T00:00:002013-12-01T00:00:00Stroke Volume16.595759776125744e-0022022-02-16T00:00:002022-02-16T00:00:00Reoperation16.584112615319739e-0022018-10-01T00:00:002018-10-01T00:00:00Workflow26.512867402478109e-0022019-02-27T00:00:002025-05-26T00:00:00Chemoradiotherapy16.505211110882243e-0022014-08-18T00:00:002014-08-18T00:00:00Pain Measurement16.418349999511210e-0022017-10-03T00:00:002017-10-03T00:00:00Immunohistochemistry36.401201444953499e-0022012-08-21T00:00:002015-09-29T00:00:00Preoperative Care26.398471598788583e-0022012-08-21T00:00:002013-12-01T00:00:00MicroRNAs16.398419840678336e-0022023-06-20T00:00:002023-06-20T00:00:00Mice, Nude16.355197033176280e-0022013-05-09T00:00:002013-05-09T00:00:00Referral and Consultation26.317895105154456e-0022013-12-01T00:00:002025-05-26T00:00:00Medical Oncology16.282276121861610e-0022019-04-23T00:00:002019-04-23T00:00:00Ethanol26.203803729398703e-0022002-11-01T00:00:002003-08-01T00:00:00Phosphorylation16.189369322776604e-0022017-09-06T00:00:002017-09-06T00:00:00Activities of Daily Living16.187915277980349e-0022016-01-01T00:00:002016-01-01T00:00:00Artificial Intelligence16.090025595070087e-0022023-06-16T00:00:002023-06-16T00:00:00Perfusion25.990371369806015e-0022008-05-27T00:00:002008-11-01T00:00:00Mentors25.989229789759024e-0022021-11-30T00:00:002022-02-01T00:00:00Spinal Cord Injuries15.848712576517015e-0022014-04-25T00:00:002014-04-25T00:00:00Neovascularization, Pathologic15.693725164516628e-0022015-07-08T00:00:002015-07-08T00:00:00Gene Expression15.665229328796079e-0022017-09-06T00:00:002017-09-06T00:00:00Adenoma15.627848979590774e-0022016-05-27T00:00:002016-05-27T00:00:00Quality Improvement25.592592001392351e-0022017-04-01T00:00:002018-03-01T00:00:00Injections, Intralesional15.348197992913915e-0022005-05-01T00:00:002005-05-01T00:00:00Lumbar Vertebrae15.325394652480092e-0022014-04-25T00:00:002014-04-25T00:00:00Regression Analysis35.254126751343929e-0022002-07-01T00:00:002016-01-01T00:00:00Follow-Up Studies45.186186009713938e-0022012-10-22T00:00:002019-04-12T00:00:00Extracellular Fluid15.158613936170307e-0022005-05-01T00:00:002005-05-01T00:00:00Biomarkers, Tumor25.150901315539005e-0022013-05-09T00:00:002016-05-27T00:00:00Health Care Surveys25.075331895819688e-0022017-04-01T00:00:002023-09-09T00:00:00Bronchography15.038702901788723e-0022003-07-01T00:00:002003-07-01T00:00:00Renin14.993867789578797e-0022025-07-18T00:00:002025-07-18T00:00:00Pleural Neoplasms14.980270992847188e-0022008-06-01T00:00:002008-06-01T00:00:00Lactates14.931343268205416e-0022024-03-01T00:00:002024-03-01T00:00:00Attitude of Health Personnel14.929930251518024e-0022018-03-01T00:00:002018-03-01T00:00:00Ferrocyanides14.924650309216597e-0022022-11-21T00:00:002022-11-21T00:00:00Pyruvic Acid14.855602007618455e-0022024-03-01T00:00:002024-03-01T00:00:00Paclitaxel14.818907972595181e-0022010-09-21T00:00:002010-09-21T00:00:00Phosphofructokinase-214.807240495789532e-0022022-09-24T00:00:002022-09-24T00:00:00Brachial Artery14.794442647367302e-0022024-09-18T00:00:002024-09-18T00:00:00Lymphography14.793762004636984e-0022023-11-20T00:00:002023-11-20T00:00:00Diagnostic Imaging14.789831688137396e-0022017-04-01T00:00:002017-04-01T00:00:00Prognosis24.773061562665144e-0022012-08-21T00:00:002022-02-16T00:00:00Systems Analysis14.773002378573318e-0022023-09-09T00:00:002023-09-09T00:00:00Radiography24.749019952860750e-0022002-09-01T00:00:002012-01-01T00:00:00alpha-Fetoproteins14.647967708928101e-0022023-03-24T00:00:002023-03-24T00:00:00Immunotherapy14.641378467059807e-0022019-04-23T00:00:002019-04-23T00:00:00Bilirubin14.540458427783472e-0022024-03-14T00:00:002024-03-14T00:00:00Rabbits24.535200839442130e-0022004-03-01T00:00:002005-05-01T00:00:00Hemostatics14.529576385600251e-0022024-09-18T00:00:002024-09-18T00:00:00Lymphatic System14.492545611281237e-0022023-11-20T00:00:002023-11-20T00:00:00Antimetabolites, Antineoplastic14.483345276806180e-0022005-10-01T00:00:002005-10-01T00:00:00Observer Variation14.479238798507510e-0022008-03-01T00:00:002008-03-01T00:00:00Sodium Chloride14.431221815213569e-0022004-01-01T00:00:002004-01-01T00:00:00Spectrometry, Fluorescence14.327614665772164e-0022003-10-01T00:00:002003-10-01T00:00:00Antihypertensive Agents24.287525250782407e-0022016-05-27T00:00:002025-07-18T00:00:00Tissue Distribution14.282519220910527e-0022005-05-01T00:00:002005-05-01T00:00:00Potassium14.271121959349204e-0022025-07-18T00:00:002025-07-18T00:00:00Patient Selection14.253739659294115e-0022013-12-01T00:00:002013-12-01T00:00:00Drug Synergism14.248247262398133e-0022005-05-01T00:00:002005-05-01T00:00:00Absorptiometry, Photon14.220323948415058e-0022007-01-23T00:00:002007-01-23T00:00:00Cyclosporine14.194425986626361e-0022003-08-01T00:00:002003-08-01T00:00:00Work Schedule Tolerance14.190303329472351e-0022025-05-26T00:00:002025-05-26T00:00:00Task Performance and Analysis14.143134753301658e-0022024-08-19T00:00:002024-08-19T00:00:00Nanostructures14.129533863465119e-0022005-10-01T00:00:002005-10-01T00:00:00Vena Cava, Inferior14.098856296564539e-0022023-12-22T00:00:002023-12-22T00:00:00Tonsillar Neoplasms14.073011707446726e-0022000-11-01T00:00:002000-11-01T00:00:00Fluorouracil14.064511809268682e-0022005-10-01T00:00:002005-10-01T00:00:00Administration, Cutaneous14.060807463925720e-0022002-11-01T00:00:002002-11-01T00:00:00Temperature24.035394908559729e-0022003-10-01T00:00:002006-06-01T00:00:00Ultrasonic Therapy14.020458883741362e-0022002-09-01T00:00:002002-09-01T00:00:00Anti-Infective Agents, Local14.011854468417101e-0022002-11-01T00:00:002002-11-01T00:00:00Hospitalization24.006485411631384e-0022016-01-01T00:00:002017-10-01T00:00:00Sorafenib14.004917358595726e-0022021-07-23T00:00:002021-07-23T00:00:00Surveys and Questionnaires43.942558257684437e-0022018-03-01T00:00:002025-05-26T00:00:00Hemorrhage23.938091708465447e-0022020-06-27T00:00:002024-03-14T00:00:00Patient Outcome Assessment13.902813706586938e-0022023-09-09T00:00:002023-09-09T00:00:00Palatine Tonsil13.870863726865965e-0022000-11-01T00:00:002000-11-01T00:00:00Dilatation and Curettage13.845880283654444e-0022019-08-10T00:00:002019-08-10T00:00:00Chest Tubes13.844316973160377e-0022020-06-27T00:00:002020-06-27T00:00:00Multicenter Studies as Topic13.839939246681606e-0022025-09-26T00:00:002025-09-26T00:00:00Remission Induction13.817682135143839e-0022025-07-18T00:00:002025-07-18T00:00:00Forms as Topic13.795514707623498e-0022019-02-27T00:00:002019-02-27T00:00:00Time-to-Pregnancy13.749804543411499e-0022019-08-10T00:00:002019-08-10T00:00:00Contrast Media33.744428891740829e-0022012-10-22T00:00:002022-11-21T00:00:00Cisplatin13.741704322215099e-0022005-10-01T00:00:002005-10-01T00:00:00Niacinamide13.718405531362410e-0022021-07-23T00:00:002021-07-23T00:00:00Hemoptysis13.700546703669529e-0022020-06-27T00:00:002020-06-27T00:00:00Video Recording13.653205896019865e-0022024-08-19T00:00:002024-08-19T00:00:00Multivariate Analysis33.651086989017845e-0022016-01-01T00:00:002016-08-11T00:00:00Workload13.648526195844484e-0022025-05-26T00:00:002025-05-26T00:00:00Pleura13.623994445386233e-0022020-06-27T00:00:002020-06-27T00:00:00Fever13.591429472282216e-0022006-06-01T00:00:002006-06-01T00:00:00Spectroscopy, Near-Infrared13.561819612980942e-0022003-10-01T00:00:002003-10-01T00:00:00Joint Commission on Accreditation of Healthcare Organizations13.544782834611207e-0022018-10-01T00:00:002018-10-01T00:00:00Forms and Records Control13.539375376398047e-0022019-02-27T00:00:002019-02-27T00:00:00Creatinine13.516474012527639e-0022024-03-14T00:00:002024-03-14T00:00:00SARS-CoV-213.508410912179768e-0022020-06-30T00:00:002020-06-30T00:00:00Thorax13.475842519556897e-0022021-04-24T00:00:002021-04-24T00:00:00Glycolysis13.436958343662491e-0022022-09-24T00:00:002022-09-24T00:00:00Radiotherapy Dosage13.434630876771787e-0022025-01-14T00:00:002025-01-14T00:00:00United States33.430504408376472e-0022018-10-01T00:00:002023-09-09T00:00:00Skin Neoplasms13.428234615827461e-0022017-09-06T00:00:002017-09-06T00:00:00Credentialing13.428217847379581e-0022018-10-01T00:00:002018-10-01T00:00:00Phenylurea Compounds13.402836522563840e-0022021-07-23T00:00:002021-07-23T00:00:00Risk Assessment33.365803311505036e-0022008-05-27T00:00:002016-08-11T00:00:00Fibroblast Growth Factors13.359128512322758e-0022023-09-28T00:00:002023-09-28T00:00:00Lactic Acid13.296899921278085e-0022022-09-24T00:00:002022-09-24T00:00:00Emergency Service, Hospital13.275702636898079e-0022017-10-01T00:00:002017-10-01T00:00:00Immunity13.200261969442805e-0022022-11-21T00:00:002022-11-21T00:00:00Feedback, Psychological13.155051969188162e-0022017-04-01T00:00:002017-04-01T00:00:00Neoplasm Invasiveness13.139932781086791e-0022025-01-14T00:00:002025-01-14T00:00:00Cattle23.135526462616359e-0022007-01-23T00:00:002016-07-25T00:00:00Clinical Coding13.028785075013342e-0022018-03-01T00:00:002018-03-01T00:00:00Agar23.008921828186342e-0022005-08-01T00:00:002006-06-01T00:00:00Vinorelbine13.003875719763967e-0022016-01-18T00:00:002016-01-18T00:00:00Fluorescent Dyes12.916330938673216e-0022003-10-01T00:00:002003-10-01T00:00:00Apoptosis42.885853625423983e-0022010-02-16T00:00:002013-10-28T00:00:00Linear Models12.872893338019204e-0022005-05-01T00:00:002005-05-01T00:00:00Neuroendocrine Tumors12.866282012666202e-0022002-07-01T00:00:002002-07-01T00:00:00Laser Therapy12.859668589954972e-0022002-11-01T00:00:002002-11-01T00:00:00Career Choice12.823548888606534e-0022021-11-30T00:00:002021-11-30T00:00:00Biomedical Research12.821408450744194e-0022011-04-01T00:00:002011-04-01T00:00:00Florida12.806421592585653e-0022016-08-11T00:00:002016-08-11T00:00:00Wounds and Injuries12.780072181633184e-0022008-05-27T00:00:002008-05-27T00:00:00Calcinosis12.751258030281007e-0022003-10-01T00:00:002003-10-01T00:00:00Fertility12.667997228672538e-0022019-08-10T00:00:002019-08-10T00:00:00Disease-Free Survival22.618931036885932e-0022012-08-21T00:00:002016-03-14T00:00:00Trachea12.585735393921133e-0022020-06-27T00:00:002020-06-27T00:00:00Neoplasm Staging22.563300351321854e-0022012-08-21T00:00:002023-03-24T00:00:00Kaplan-Meier Estimate22.529431583158998e-0022011-12-30T00:00:002016-03-14T00:00:00Analysis of Variance22.511078650997725e-0022010-09-21T00:00:002012-11-20T00:00:00Abortion, Induced12.497738497513918e-0022019-08-10T00:00:002019-08-10T00:00:00Ischemia12.491157954521784e-0022023-05-12T00:00:002023-05-12T00:00:00Lymphoma, Non-Hodgkin12.458694876682160e-0022000-11-01T00:00:002000-11-01T00:00:00Chronic Disease12.435933872080901e-0022008-03-01T00:00:002008-03-01T00:00:00Personal Satisfaction12.424558806549859e-0022018-03-01T00:00:002018-03-01T00:00:00Sulfur Hexafluoride12.420050723045771e-0022012-10-22T00:00:002012-10-22T00:00:00Diagnosis, Differential12.391883803335662e-0022008-03-01T00:00:002008-03-01T00:00:00Sensitivity and Specificity12.383050175530891e-0022008-03-01T00:00:002008-03-01T00:00:00Triiodobenzoic Acids12.378806920602100e-0022012-12-01T00:00:002012-12-01T00:00:00Models, Biological12.298581564146587e-0022008-05-27T00:00:002008-05-27T00:00:00Iohexol12.261845773841707e-0022012-12-01T00:00:002012-12-01T00:00:00Adolescent52.201258537994246e-0022000-07-01T00:00:002016-08-11T00:00:00Mice, Inbred BALB C12.112246306249401e-0022019-12-17T00:00:002019-12-17T00:00:00Retreatment12.102255574218907e-0022012-10-22T00:00:002012-10-22T00:00:00Immunosuppressive Agents12.006937154168200e-0022003-08-01T00:00:002003-08-01T00:00:00Antineoplastic Combined Chemotherapy Protocols12.005043833337808e-0022011-12-30T00:00:002011-12-30T00:00:00Logistic Models22.002207304493409e-0022012-12-01T00:00:002016-08-11T00:00:00COVID-1911.978675515340807e-0022020-06-30T00:00:002020-06-30T00:00:008-Hydroxy-2'-Deoxyguanosine11.978634313312581e-0022010-02-16T00:00:002010-02-16T00:00:00Radiography, Thoracic11.977985269748034e-0022017-07-01T00:00:002017-07-01T00:00:00Deoxyguanosine11.928915705613148e-0022010-02-16T00:00:002010-02-16T00:00:00Clinical Decision-Making11.870665318573691e-0022019-02-27T00:00:002019-02-27T00:00:00Health Personnel11.858776681427929e-0022023-09-09T00:00:002023-09-09T00:00:00Endpoint Determination11.828742086945372e-0022011-12-30T00:00:002011-12-30T00:00:00Aldehydes11.815249220332164e-0022010-02-16T00:00:002010-02-16T00:00:00Phospholipids11.813074753544158e-0022012-10-22T00:00:002012-10-22T00:00:00Acetylcysteine11.795278670013482e-0022010-02-16T00:00:002010-02-16T00:00:00Disability Evaluation11.787134004215305e-0022016-01-01T00:00:002016-01-01T00:00:00Cytokines11.777900268960145e-0022023-09-28T00:00:002023-09-28T00:00:00Thermography11.758832399187030e-0022008-11-01T00:00:002008-11-01T00:00:00Survival Rate21.754041151909003e-0022012-08-21T00:00:002012-10-22T00:00:00Image Processing, Computer-Assisted11.719044371641856e-0022005-05-01T00:00:002005-05-01T00:00:00Caspase 311.699079056938764e-0022010-02-16T00:00:002010-02-16T00:00:00Point-of-Care Systems11.687099107002420e-0022017-07-01T00:00:002017-07-01T00:00:00Biopsy, Needle11.661452624619459e-0022012-08-21T00:00:002012-08-21T00:00:00Nephrectomy11.631455056545510e-0022012-08-21T00:00:002012-08-21T00:00:00Quality Indicators, Health Care11.614431509261721e-0022017-04-01T00:00:002017-04-01T00:00:00Immunoenzyme Techniques11.600598300632602e-0022010-02-16T00:00:002010-02-16T00:00:00Staining and Labeling11.523288231271104e-0022010-09-21T00:00:002010-09-21T00:00:00Clinical Trials as Topic11.512982294699421e-0022002-09-01T00:00:002002-09-01T00:00:00Cell Survival11.503932796039131e-0022016-01-18T00:00:002016-01-18T00:00:00Computer Graphics11.484798543898911e-0022008-05-27T00:00:002008-05-27T00:00:00Finite Element Analysis11.466748421043576e-0022008-05-27T00:00:002008-05-27T00:00:00Tyrosine11.463227174425669e-0022010-02-16T00:00:002010-02-16T00:00:00Medicare11.390906149670467e-0022023-09-09T00:00:002023-09-09T00:00:00Odds Ratio11.350972214906876e-0022016-08-11T00:00:002016-08-11T00:00:00Mass Screening11.331520798857217e-0022000-11-01T00:00:002000-11-01T00:00:00Arsenic Trioxide11.316286823889764e-0022004-03-01T00:00:002004-03-01T00:00:00Adrenergic Agonists11.308898605416736e-0022004-03-01T00:00:002004-03-01T00:00:00Halothane11.290574825437790e-0022004-03-01T00:00:002004-03-01T00:00:00Laser-Doppler Flowmetry11.267430478997683e-0022004-03-01T00:00:002004-03-01T00:00:00Arsenicals11.266241323431103e-0022004-03-01T00:00:002004-03-01T00:00:00Physician-Patient Relations11.263589160223889e-0022017-04-01T00:00:002017-04-01T00:00:00Calcium Oxalate11.236181298302925e-0022003-10-01T00:00:002003-10-01T00:00:00Biomarkers11.234905630115027e-0022025-07-18T00:00:002025-07-18T00:00:00Survival Analysis11.203060927648479e-0022015-05-22T00:00:002015-05-22T00:00:00Durapatite11.152614819353024e-0022003-10-01T00:00:002003-10-01T00:00:00Oxides11.145368691405039e-0022004-03-01T00:00:002004-03-01T00:00:00Academic Medical Centers11.136650162790534e-0022012-08-21T00:00:002012-08-21T00:00:00Autoradiography11.106004767348717e-0022002-09-01T00:00:002002-09-01T00:00:00Incidence11.099413392765942e-0022020-06-27T00:00:002020-06-27T00:00:00Surface-Active Agents11.095319524970801e-0022002-03-01T00:00:002002-03-01T00:00:00Proportional Hazards Models11.086581585395392e-0022016-03-14T00:00:002016-03-14T00:00:00Cohort Studies21.083163659221508e-0022012-08-21T00:00:002016-01-01T00:00:00Pneumonectomy11.072380566657963e-0022008-06-01T00:00:002008-06-01T00:00:00Tonsillitis11.054610815371532e-0022000-11-01T00:00:002000-11-01T00:00:00Pseudolymphoma11.047051677715841e-0022000-11-01T00:00:002000-11-01T00:00:00Databases, Factual11.029432609134816e-0022016-08-11T00:00:002016-08-11T00:00:00Child31.029229635551102e-0022000-07-01T00:00:002012-12-01T00:00:00In Vitro Techniques11.025820448153540e-0022007-01-23T00:00:002007-01-23T00:00:00Epinephrine11.016647059342693e-0022004-03-01T00:00:002004-03-01T00:00:00Regional Blood Flow11.014700771590638e-0022004-03-01T00:00:002004-03-01T00:00:00Child, Preschool21.002008112221882e-0022000-07-01T00:00:002000-11-01T00:00:00Cross-Sectional Studies19.965981566925380e-0032022-02-01T00:00:002022-02-01T00:00:00DNA Damage19.849656146648442e-0032010-02-16T00:00:002010-02-16T00:00:00Signal Processing, Computer-Assisted19.742787684859951e-0032007-01-23T00:00:002007-01-23T00:00:00Practice Patterns, Physicians'19.551735414171474e-0032017-04-01T00:00:002017-04-01T00:00:00Contraindications19.435353429733166e-0032000-11-01T00:00:002000-11-01T00:00:00Histones19.416144977828419e-0032010-02-16T00:00:002010-02-16T00:00:00Pakistan19.393197403590719e-0032000-11-01T00:00:002000-11-01T00:00:00Anesthetics, Inhalation19.320790741666432e-0032004-03-01T00:00:002004-03-01T00:00:00Pulmonary Embolism19.265692543738165e-0032012-12-01T00:00:002012-12-01T00:00:00Body Temperature Regulation19.192255913088412e-0032001-04-01T00:00:002001-04-01T00:00:00Body Composition19.050983334081591e-0032008-05-27T00:00:002008-05-27T00:00:00Oxidative Stress18.987362521547627e-0032010-02-16T00:00:002010-02-16T00:00:00Pregnancy18.250073842234676e-0032019-08-10T00:00:002019-08-10T00:00:00Infusions, Intravenous18.182977309257343e-0032002-03-01T00:00:002002-03-01T00:00:00Models, Animal17.593769333224565e-0032002-09-01T00:00:002002-09-01T00:00:00Hypertension17.339470596715932e-0032016-05-27T00:00:002016-05-27T00:00:00Medical Records17.184159547216899e-0032000-11-01T00:00:002000-11-01T00:00:00Disease Progression17.115049488907731e-0032012-10-22T00:00:002012-10-22T00:00:00Case-Control Studies16.936192758645181e-0032012-12-01T00:00:002012-12-01T00:00:00Tumor Cells, Cultured16.783198209005126e-0032002-03-01T00:00:002002-03-01T00:00:00Carcinoma15.977637953013758e-0032004-03-01T00:00:002004-03-01T00:00:00Dose-Response Relationship, Drug14.664161355654521e-0032001-04-01T00:00:002001-04-01T00:00:00Cost-Benefit Analysis14.101639016436694e-0032000-11-01T00:00:002000-11-01T00:00:00Genetic Predisposition to Disease13.813199269428695e-0032008-06-01T00:00:002008-06-01T00:00:00Infant13.651259699777204e-0032008-06-01T00:00:002008-06-01T00:00:00Tasnim Ahmed, M.D.TasnimAhmed

Beth Israel Deaconess Medical CenterDivision: Adm-House Staff330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterMedicineAdm-House StaffClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/39122232Generative Artificial Intelligence Tools in Gastroenterology Training. Clin Gastroenterol Hepatol. 2024 Oct; 22(10):1975-1978.Ahmed T, Rabinowitz LG, Rodman A, Berzin TM. Clin Gastroenterol Hepatol2024 Oct22(10):1975-1978Gastroenterology15.359382875691111e-0012024-08-06T00:00:002024-08-06T00:00:00Artificial Intelligence12.636618017260949e-0012024-08-06T00:00:002024-08-06T00:00:00Humans19.611570038755081e-0032024-08-06T00:00:002024-08-06T00:00:00Usman Ahmed, M.B.,B.S.UsmanAhmed

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaClinical ResearchResearch Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41680053Peak Gradients and Left Ventricular Outflow Tract Area in Hypertrophic Obstructive Cardiomyopathy:A 3-Dimensional Echocardiography Study. J Cardiothorac Vasc Anesth. 2026 Apr; 40(4):1112-1121.Sharkey A, Ahmed U, Manji AA, Mahmood F, Saeed S, Valencia J, Fatima H, Matyal R, Rastegar H, Khabbaz KR. J Cardiothorac Vasc Anesth2026 Apr40(4):1112-1121http://www.ncbi.nlm.nih.gov/pubmed/41377471Impaired PGC-1a-pAMPK signaling in postmenopausal women undergoing cardiac surgery and the role of nicotinamide in its reversal: Insights from a murine model. J Mol Cell Cardiol Plus. 2025 Dec; 14:100831.Robitaille M, Ahmed U, Valencia J, Khan A, Manji AA, Russ E, Chu L, Khabbaz K, Mahmood F, Matyal R. J Mol Cell Cardiol Plus2025 Dec14:100831http://www.ncbi.nlm.nih.gov/pubmed/41152120Atypical Tricuspid Valve Anatomy: Adding Value with 3-Dimensional Imaging. J Cardiothorac Vasc Anesth. 2026 Jan; 40(1):392-393.Ahmed U, Manji AA, Hussain HS, Saeed S, Valencia J, Laham R, Mahmood F, Sharkey A. J Cardiothorac Vasc Anesth2026 Jan40(1):392-393http://www.ncbi.nlm.nih.gov/pubmed/41245054Sex Differences in 90-Day Readmission and Mortality Trends in Heart Failure With Preserved Ejection Fraction: Insights From the National Readmissions Database. Int J Heart Fail. 2025 Oct; 7(4):216-226.Ahmed U, Hussain H, Saeed S, Manji AA, Valencia J, Yunus R, Robitaille M, Chen G, Mahmood F, Matyal R. Int J Heart Fail2025 Oct7(4):216-226http://www.ncbi.nlm.nih.gov/pubmed/40987638The Rotated Aortic Root: A Hidden Anatomical Variant Revealed by Three-dimensional Echocardiography. J Cardiothorac Vasc Anesth. 2026 Feb; 40(2):758-760.Ahmed U, Noor F, Ahmad S, Sharkey A, Robitaille M, Mahmood F. J Cardiothorac Vasc Anesth2026 Feb40(2):758-760http://www.ncbi.nlm.nih.gov/pubmed/40762637Peripheral Nerve Blocks for Enhanced Recovery in Cardiac Surgery: A Retrospective Observational Study. Ann Card Anaesth. 2025 Oct 01; 28(4):392-400.Sharkey A, Khan AA, Saeed S, Yunus RA, Ahmed U, Manji AA, Bose R, Khabbaz K, Mahmood F, Matyal R. Ann Card Anaesth2025 Oct 0128(4):392-400http://www.ncbi.nlm.nih.gov/pubmed/40747423Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma. bioRxiv. 2025 Jul 17.Gupta S, Khanna P, Saad E, Saliby RM, AbuHammad S, Li J, Li B, Konda P, Ahmed UA, Sadagopan A, Xu Q, Bakouny Z, Xu W, Srinivasan R, Choueiri TK, Viswanathan SR. bioRxiv2025 Jul 17http://www.ncbi.nlm.nih.gov/pubmed/40483247Right Ventricular Function and Echocardiographic Pressure-Volume Loops: Overview and Perioperative Clinical Implications. J Cardiothorac Vasc Anesth. 2025 Oct; 39(10):2857-2865.Ahmed U, Mahmood F, Nicoara A, Kiarad V. J Cardiothorac Vasc Anesth2025 Oct39(10):2857-2865http://www.ncbi.nlm.nih.gov/pubmed/40287128Sex Disparities in Medical Management: Influence on Morbidity in Peripheral Arterial Disease. Ann Vasc Surg. 2025 Oct; 119:67-78.Zhong Q, Ahmed U, Yunus RA, Saeed S, Sohail M, Manji A, Robitaille M, Schermerhorn ML, Mahmood F, Matyal R. Ann Vasc Surg2025 Oct119:67-78http://www.ncbi.nlm.nih.gov/pubmed/39705583Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations. J Extra Corpor Technol. 2024 Dec; 56(4):191-202.Pervaiz Butt S, Kakar V, Abdulaziz S, Razzaq N, Saleem Y, Kumar A, Ashiq F, Ghisulal P, Thrush A, Malik S, Griffin M, Amir M, Khan U, Salim A, Zoumot Z, Mydin I, Aljabery Y, Bhatnagar G, Bayrak Y, Obeso A, Ahmed U. J Extra Corpor Technol2024 Dec56(4):191-202http://www.ncbi.nlm.nih.gov/pubmed/39794195Sex-Based Differences in Ruptured Abdominal Aortic Aneurysm Management and Outcomes: An Update. J Cardiothorac Vasc Anesth. 2025 Mar; 39(3):711-723.Saeed S, Robitaille M, Ahmed U, Yunus RA, Sohail M, Levy N, Neves S, Schermerhorn ML, Matyal R, Mahmood F. J Cardiothorac Vasc Anesth2025 Mar39(3):711-723http://www.ncbi.nlm.nih.gov/pubmed/39168126A genetic basis for sex differences in Xp11 translocation renal cell carcinoma. Cell. 2024 Oct 03; 187(20):5735-5752.e25.Achom M, Sadagopan A, Bao C, McBride F, Li J, Konda P, Tourdot RW, Xu Q, Nakhoul M, Gallant DS, Ahmed UA, O'Toole J, Freeman D, Lee GM, Hecht JL, Kauffman EC, Einstein DJ, Choueiri TK, Zhang CZ, Viswanathan SR. Cell2024 Oct 03187(20):5735-5752.e25http://www.ncbi.nlm.nih.gov/pubmed/38623957Long-term clinical outcomes of intravascular imaging-guided percutaneous coronary intervention versus angiography-guided percutaneous coronary intervention in complex coronary lesions: a systematic review and meta-analysis. Future Cardiol. 2024; 20(3):137-150.Ashraf DA, Ahmed U, Khan ZZ, Mushtaq F, Bano S, Khan AR, Azam S, Haroon A, Malik SA, Aslam R, Kumar J, Khan FZ, Faheem A, Kumar S, Hassan S. Future Cardiol202420(3):137-150http://www.ncbi.nlm.nih.gov/pubmed/37577497A genetic basis for cancer sex differences revealed in Xp11 translocation renal cell carcinoma. bioRxiv. 2023 Aug 06.Achom M, Sadagopan A, Bao C, McBride F, Xu Q, Konda P, Tourdot RW, Li J, Nakhoul M, Gallant DS, Ahmed UA, O'Toole J, Freeman D, Mary Lee GS, Hecht JL, Kauffman EC, Einstein DJ, Choueiri TK, Zhang CZ, Viswanathan SR. bioRxiv2023 Aug 06http://www.ncbi.nlm.nih.gov/pubmed/37593294Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review. Cureus. 2023 Jul; 15(7):e41991.Khan ZZ, Ahmed U, Shahzad F, Ali M, Tousif K, Ahmed U, Muhammad Safwan Q, Naufil SI, Murtaza S, Saeed S, Basit J, Haider T, Shabbir H. Cureus2023 Jul15(7):e41991Ventricular Function, Right16.565388487640231e-0012025-05-17T00:00:002025-05-17T00:00:00Ventricular Dysfunction, Right16.056557710171666e-0012025-05-17T00:00:002025-05-17T00:00:00Perioperative Care14.903250388994787e-0012025-05-17T00:00:002025-05-17T00:00:00Lung Transplantation14.492481941796379e-0012024-12-20T00:00:002024-12-20T00:00:00Extracorporeal Membrane Oxygenation13.891909224143940e-0012024-12-20T00:00:002024-12-20T00:00:00Echocardiography13.656800608890679e-0012025-05-17T00:00:002025-05-17T00:00:00Ventricular Outflow Obstruction11.962969425290459e-0012026-01-11T00:00:002026-01-11T00:00:00Chromosomes, Human, X11.856605538426647e-0012024-08-20T00:00:002024-08-20T00:00:00Enhanced Recovery After Surgery11.808287189644998e-0012025-08-05T00:00:002025-08-05T00:00:00Basic Helix-Loop-Helix Leucine Zipper Transcription Factors11.770536727269459e-0012024-08-20T00:00:002024-08-20T00:00:00Aortic Rupture11.768462735758007e-0012024-12-19T00:00:002024-12-19T00:00:00Peripheral Nerves11.742535570068487e-0012025-08-05T00:00:002025-08-05T00:00:00Echocardiography, Three-Dimensional11.624872491441222e-0012026-01-11T00:00:002026-01-11T00:00:00Translocation, Genetic11.457915554072221e-0012024-08-20T00:00:002024-08-20T00:00:00Nerve Block11.439799259263775e-0012025-08-05T00:00:002025-08-05T00:00:00Sex Characteristics21.298651641942818e-0012024-08-20T00:00:002024-12-19T00:00:00Cardiomyopathy, Hypertrophic11.203007021284629e-0012026-01-11T00:00:002026-01-11T00:00:00Vascular Surgical Procedures11.180035012157084e-0012025-04-24T00:00:002025-04-24T00:00:00Ultrasonography, Interventional11.146464533445170e-0012024-04-16T00:00:002024-04-16T00:00:00Aortic Aneurysm, Abdominal11.108284726649444e-0012024-12-19T00:00:002024-12-19T00:00:00Postoperative Pain11.089736214879116e-0012025-08-05T00:00:002025-08-05T00:00:00Hypertension, Pulmonary11.033249586253602e-0012025-05-17T00:00:002025-05-17T00:00:00Disease Management11.025774124417574e-0012024-12-19T00:00:002024-12-19T00:00:00Heart Ventricles19.956085406970419e-0022026-01-11T00:00:002026-01-11T00:00:00Health Status Disparities19.555933570256918e-0022025-04-24T00:00:002025-04-24T00:00:00Peripheral Arterial Disease19.444373463228444e-0022025-04-24T00:00:002025-04-24T00:00:00Coronary Angiography19.402995350665777e-0022024-04-16T00:00:002024-04-16T00:00:00Percutaneous Coronary Intervention18.668335067444670e-0022024-04-16T00:00:002024-04-16T00:00:00Endovascular Procedures17.897258054318972e-0022024-12-19T00:00:002024-12-19T00:00:00Cardiac Surgical Procedures17.579076533117737e-0022025-08-05T00:00:002025-08-05T00:00:00Carcinoma, Renal Cell17.296444727477823e-0022024-08-20T00:00:002024-08-20T00:00:00Healthcare Disparities16.944057573548761e-0022025-04-24T00:00:002025-04-24T00:00:00Kidney Neoplasms16.535601425811724e-0022024-08-20T00:00:002024-08-20T00:00:00Treatment Outcome45.857639680301011e-0022024-04-16T00:00:002025-04-24T00:00:00Ropivacaine15.799137370662007e-0022025-08-05T00:00:002025-08-05T00:00:00Postoperative Complications25.519327538121299e-0022024-12-19T00:00:002025-04-24T00:00:00Coronary Artery Disease15.325153791090850e-0022024-04-16T00:00:002024-04-16T00:00:00Sex Factors24.215339122009348e-0022024-12-19T00:00:002025-04-24T00:00:00Anesthetics, Local13.651488579905713e-0022025-08-05T00:00:002025-08-05T00:00:00Humans83.498683562193111e-0022024-04-16T00:00:002026-01-11T00:00:00Haplotypes13.465069823049033e-0022024-08-20T00:00:002024-08-20T00:00:00Surgery, Computer-Assisted12.954745299187556e-0022024-04-16T00:00:002024-04-16T00:00:00Retrospective Studies42.952548500373668e-0022024-12-19T00:00:002026-01-11T00:00:00Oncogene Proteins, Fusion12.951196503875820e-0022024-08-20T00:00:002024-08-20T00:00:00Aged42.229365250582995e-0022024-12-19T00:00:002026-01-11T00:00:00Length of Stay12.156401436144920e-0022025-08-05T00:00:002025-08-05T00:00:00Middle Aged41.995427720523965e-0022024-12-19T00:00:002026-01-11T00:00:00Tomography, Optical Coherence11.955036794691196e-0022024-04-16T00:00:002024-04-16T00:00:00Male51.918343537045250e-0022024-08-20T00:00:002026-01-11T00:00:00Databases, Factual11.881571833124618e-0022025-04-24T00:00:002025-04-24T00:00:00Aged, 80 and over21.856120338343039e-0022024-12-19T00:00:002025-04-24T00:00:00Female51.815666160767202e-0022024-08-20T00:00:002026-01-11T00:00:00Risk Assessment11.259410364469890e-0022025-04-24T00:00:002025-04-24T00:00:00Time Factors11.241231632674128e-0022025-04-24T00:00:002025-04-24T00:00:00Cohort Studies11.125237612756406e-0022024-12-19T00:00:002024-12-19T00:00:00Risk Factors18.415529888562416e-0032025-04-24T00:00:002025-04-24T00:00:00United States17.809307140803349e-0032025-04-24T00:00:002025-04-24T00:00:00Adult15.182217013158730e-0032026-01-11T00:00:002026-01-11T00:00:00Zahin Ahmed, M.D.ZahinAhmed

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaClinical ResearchClinical Fellow in AnaesthesiaFellow or Post DocAnjali P. Ahn, M.D.AnjaliAhn

Beth Israel Deaconess Medical CenterPulmonary, Critical Care & Sleep Medicine, KSB 36330 Brookline AveBoston, MA 02215617/667-586442.34720000000000-71.14180000000000

1BIDMCBeth Israel Deaconess Medical CenterMedicinePulmonaryAssistant Professor of MedicineAssistant ProfessorLynne Ahn, M.D.LynneAhn

Beth Israel Deaconess Medical CenterDivision: Gastroenterology330 Brookline AveBoston, MA 02215617/667-1846

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyInstructor in MedicineInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/22689913The Your Disease Risk Index for colorectal cancer is an inaccurate risk stratification tool for advanced colorectal neoplasia at screening colonoscopy. Cancer Prev Res (Phila). 2012 Aug; 5(8):1044-52.Schroy PC, Coe AM, Mylvaganam SR, Ahn LB, Lydotes MA, Robinson PA, Davis JT, Chen CA, Ashba J, Atkinson ML, Colditz GA, Heeren TC. Cancer Prev Res (Phila)2012 Aug5(8):1044-52http://www.ncbi.nlm.nih.gov/pubmed/16401495Statins and colorectal cancer risk: a new panacea? Gastroenterology. 2006 Jan; 130(1):278-80.Ahn LB, Schroy PC. Gastroenterology2006 Jan130(1):278-80http://www.ncbi.nlm.nih.gov/pubmed/15905716Crohn's disease after gastric bypass surgery for morbid obesity: is there an association? Inflamm Bowel Dis. 2005 Jun; 11(6):622-4.Ahn LB, Huang CS, Forse RA, Hess DT, Andrews C, Farraye FA. Inflamm Bowel Dis2005 Jun11(6):622-4Gastric Bypass11.256762528388283e-0012005-06-01T00:00:002005-06-01T00:00:00Obesity, Morbid11.051198003041811e-0012005-06-01T00:00:002005-06-01T00:00:00Crohn Disease19.173096280680215e-0022005-06-01T00:00:002005-06-01T00:00:00Colonoscopy15.102418131451731e-0022012-06-11T00:00:002012-06-11T00:00:00Abdominal Pain13.615877238582339e-0022005-06-01T00:00:002005-06-01T00:00:00Diarrhea13.474304291967791e-0022005-06-01T00:00:002005-06-01T00:00:00Mass Screening12.977133049832703e-0022012-06-11T00:00:002012-06-11T00:00:00Weight Loss12.502833941176282e-0022005-06-01T00:00:002005-06-01T00:00:00Colorectal Neoplasms12.242263706305350e-0022012-06-11T00:00:002012-06-11T00:00:00Risk Assessment12.064737784578925e-0022012-06-11T00:00:002012-06-11T00:00:00Risk Factors21.192564276373100e-0022005-06-01T00:00:002012-06-11T00:00:00Middle Aged26.987046343391897e-0032005-06-01T00:00:002012-06-11T00:00:00Prevalence16.910763817774125e-0032012-06-11T00:00:002012-06-11T00:00:00Prognosis15.399316218470137e-0032012-06-11T00:00:002012-06-11T00:00:00Female25.144625391288295e-0032005-06-01T00:00:002012-06-11T00:00:00Follow-Up Studies15.133045722912112e-0032012-06-11T00:00:002012-06-11T00:00:00Adult14.966541526299446e-0032005-06-01T00:00:002005-06-01T00:00:00Humans23.578043742629991e-0032005-06-01T00:00:002012-06-11T00:00:00United States13.200738214463096e-0032012-06-11T00:00:002012-06-11T00:00:00Aged12.257751669739750e-0032012-06-11T00:00:002012-06-11T00:00:00Male11.572104687419970e-0032012-06-11T00:00:002012-06-11T00:00:00Elena Ahrens, M.D.ElenaAhrens

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaClinical ResearchResearch Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41717663Dose-dependent relationship between intra-operative dexmedetomidine and delirium after non-cardiac surgery: a retrospective cohort study. Anaesthesia. 2026 Feb 20.Ahrens E, Wachtendorf LJ, Tenge T, Riesemann S, Kaiser L, Chen G, Neves SE, Robitaille MJ, Xu X, Allain RM, Ma H, Schaefer MS. Anaesthesia2026 Feb 20http://www.ncbi.nlm.nih.gov/pubmed/41660365Association of intraoperative dexamethasone administration with postoperative delirium and the role of hyperglycaemia: a retrospective cohort study. EClinicalMedicine. 2026 Feb; 92:103771.Riesemann S, Tenge T, Ahrens E, Wachtendorf LJ, Paschold BS, Shay D, von Wedel D, Liebich K, Student JP, Fligor SC, Kaiser L, Xu X, Katsiampoura A, Valeri L, Novack V, Kent TS, Ma H, Schaefer MS. EClinicalMedicine2026 Feb92:103771http://www.ncbi.nlm.nih.gov/pubmed/41343719Changes in Intraoperative Rocuronium Dosing after the Introduction of Sugammadex and Association with Postoperative Respiratory Complications: A Retrospective Cohort Study. Anesthesiology. 2026 Mar 01; 144(3):597-610.Wachtendorf LJ, Kaiser L, Ahrens E, Tenge T, Riesemann S, Xu X, Shay D, von Wedel D, Paschold BS, Chen G, Kiziltug H, Ramachandran SK, Fassbender PJ, Kienbaum P, Eikermann M, Schaefer MS. Anesthesiology2026 Mar 01144(3):597-610http://www.ncbi.nlm.nih.gov/pubmed/41212517Acetaminophen 5-HT 3 Antagonist Interaction: Reply. Anesthesiology. 2026 Jan 01; 144(1):246-247.Ahrens E, Ratajczak N, Schaefer MS. Anesthesiology2026 Jan 01144(1):246-247http://www.ncbi.nlm.nih.gov/pubmed/41048666Development and validation of a prediction score for early identification of palliative care needs for patients in the intensive care unit: a multicentre retrospective cohort study. EClinicalMedicine. 2025 Nov; 89:103519.Tenge T, Hadler R, Mahal E, Ahrens E, Wachtendorf LJ, Redaelli S, Riesemann S, Paschold BS, Chen G, Khan S, Schwartz J, Schallenburger M, Allain RM, Lee K, Neukirchen M, Schaefer MS. EClinicalMedicine2025 Nov89:103519http://www.ncbi.nlm.nih.gov/pubmed/40923837Race, Ethnicity, and Antiemetic Management: Comment. Anesthesiology. 2025 Oct 01; 143(4):1134-1135.Ahrens E, Schaefer MS, Wachtendorf LJ. Anesthesiology2025 Oct 01143(4):1134-1135http://www.ncbi.nlm.nih.gov/pubmed/40619168Dose-dependent relationship between intra-operative ketamine administration and postoperative delirium: a retrospective cohort study. Anaesthesia. 2025 Nov; 80(11):1360-1369.Kaiser L, Paschold BS, Wachtendorf LJ, Ahrens E, Tenge T, Redaelli S, Hentges M, Sahli SD, Chen G, Novack V, Eikermann M, Ma H, Schaefer MS. Anaesthesia2025 Nov80(11):1360-1369http://www.ncbi.nlm.nih.gov/pubmed/40493793Hepatopulmonary syndrome: pathophysiological mechanisms and clinical implications. Curr Opin Anaesthesiol. 2025 Aug 01; 38(4):485-491.La Via L, Ahrens E, Voza A, Tesauro M, Zanza C, Longhitano Y. Curr Opin Anaesthesiol2025 Aug 0138(4):485-491http://www.ncbi.nlm.nih.gov/pubmed/40532893Comparison of established comorbidity scores using administrative data of patients undergoing surgery or interventional procedures in Massachusetts. J Clin Epidemiol. 2025 Sep; 185:111869.Ahrens E, von Wedel D, Redaelli S, Tenge T, Wachtendorf LJ, Munoz-Acuna R, Chen G, Schaefer MS, Shay D. J Clin Epidemiol2025 Sep185:111869http://www.ncbi.nlm.nih.gov/pubmed/40492659The role of veno-venous bypass in liver transplant. Curr Opin Anaesthesiol. 2025 Aug 01; 38(4):478-484.Ahrens E, Caputo G, Planinsic R, Zanza C, Longhitano Y. Curr Opin Anaesthesiol2025 Aug 0138(4):478-484http://www.ncbi.nlm.nih.gov/pubmed/40251137Association Between Neuromuscular Blockade and Its Reversal With Postoperative Delirium in Older Patients: A Hospital Registry Study. Anesth Analg. 2025 Aug 01; 141(2):363-372.Ahrens E, Wachtendorf LJ, Shay D, Tenge T, Paschold BS, Rudolph MI, Redaelli S, Kaiser L, Suleiman A, Ma H, Fassbender PJ, Schaefer MS. Anesth Analg2025 Aug 01141(2):363-372http://www.ncbi.nlm.nih.gov/pubmed/40204668Association of cannabis use with major cardiovascular and cerebrovascular events after surgery or interventional procedures. Am J Addict. 2025 Sep; 34(5):517-527.Ashrafian S, Ahrens E, Wachtendorf LJ, Munoz-Acuna R, Shay D, Suleiman A, Redaelli S, von Wedel D, Chen G, Wolff G, Hill KP, Schaefer MS. Am J Addict2025 Sep34(5):517-527http://www.ncbi.nlm.nih.gov/pubmed/40197456Acetaminophen 5-HT3 Antagonist Interaction: Reply. Anesthesiology. 2025 May 01; 142(5):952-954.Ratajczak N, Ahrens E, Wachtendorf LJ, Schaefer MS. Anesthesiology2025 May 01142(5):952-954http://www.ncbi.nlm.nih.gov/pubmed/39863469Preoperative SGLT-2 inhibitor use and risk of adverse postoperative events: a single-centre retrospective observational study. Br J Anaesth. 2025 Apr; 134(4):1214-1217.Tenge T, Roth S, Ahrens E, Wachtendorf LJ, Paschold BS, Chen G, M'Pembele R, Kindgen-Milles D, Katsiampoura A, Kienbaum P, Buse GL, Schaefer MS. Br J Anaesth2025 Apr134(4):1214-1217http://www.ncbi.nlm.nih.gov/pubmed/39392782Intraoperative Vasopressors and Delirium: Reply. Anesthesiology. 2024 Dec 01; 141(6):1211-1212.Ma H, Ahrens E, Wachtendorf LJ, Chen G, Rhee J, Schaefer MS. Anesthesiology2024 Dec 01141(6):1211-1212http://www.ncbi.nlm.nih.gov/pubmed/39617807Considerations for Anesthesia in Older Adults with Cannabis Use. Drugs Aging. 2024 12; 41(12):933-943.Ahrens E, Wachtendorf LJ, Hill KP, Schaefer MS. Drugs Aging2024 1241(12):933-943http://www.ncbi.nlm.nih.gov/pubmed/39495288Preoperative hypoxic biomarkers and postoperative delirium in patients with obstructive sleep apnea. J Anesth. 2025 Feb; 39(1):31-40.Breitkopf M, Ahrens E, Herrmann ML, Heinemann S, Kuester O, Ma H, Walther A, Thomas C, Eschweiler GW, von Arnim CAF, Wagner S. J Anesth2025 Feb39(1):31-40http://www.ncbi.nlm.nih.gov/pubmed/39804591Real-World Evaluation of i-gel Introduction on Intraoperative Airway-Related Safety Events: A Retrospective Cohort Study From a New England Hospital Network. Anesth Analg. 2025 Feb 01; 140(2):253-261.Obeidat SS, Suleiman A, Ahrens E, Needham MJ, Stewart C, Khany M, Tartler TM, Zucco L, Pandit JJ, Schaefer MS, Ramachandran SK. Anesth Analg2025 Feb 01140(2):253-261http://www.ncbi.nlm.nih.gov/pubmed/39191081The association between intraoperative low driving pressure ventilation and perioperative healthcare-associated costs: A retrospective multicenter cohort study. J Clin Anesth. 2024 11; 98:111567.Wachtendorf LJ, Ahrens E, Suleiman A, von Wedel D, Tartler TM, Rudolph MI, Redaelli S, Santer P, Munoz-Acuna R, Santarisi A, Calderon HN, Kiyatkin ME, Novack L, Talmor D, Eikermann M, Schaefer MS. J Clin Anesth2024 1198:111567http://www.ncbi.nlm.nih.gov/pubmed/38700445Increased Postoperative Opioid Consumption in the Presence of Coadministration of 5-Hydroxytryptamine Type 3 Antagonists with Acetaminophen: A Hospital Registry Study. Anesthesiology. 2024 Aug 01; 141(2):326-337.Ratajczak N, Munoz-Acuna R, Redaelli S, Suleiman A, Seibold EL, von Wedel D, Shay D, Ashrafian S, Chen G, Sundar E, Ahrens E, Wachtendorf LJ, Schaefer MS. Anesthesiology2024 Aug 01141(2):326-337http://www.ncbi.nlm.nih.gov/pubmed/39058628Previous Coronavirus Disease-2019 Infection and Lung Mechanics in Surgical Patients: A Hospital Registry Study. Anesth Analg. 2024 Nov 01; 139(5):997-1005.Suleiman A, Munoz-Acuna R, Redaelli S, Ahrens E, Tartler TM, Ashrafian S, Hashish MM, Santarisi A, Chen G, Riedel S, Talmor D, Baedorf Kassis EN, Schaefer MS, Goodspeed V. Anesth Analg2024 Nov 01139(5):997-1005http://www.ncbi.nlm.nih.gov/pubmed/38965629Impact of the COVID-19 pandemic on lung-protective ventilation practice in critically ill patients with respiratory failure: a retrospective cohort study from a New England healthcare network. Crit Care. 2024 07 04; 28(1):219.Munoz-Acuna R, Ahrens E, Suleiman A, Wachtendorf LJ, Azizi BA, Redaelli S, Tartler TM, Chen G, Baedorf-Kassis EN, Schaefer MS, Siddiqui S. Crit Care2024 07 0428(1):219http://www.ncbi.nlm.nih.gov/pubmed/38926028Association of anaesthesia provider sex with perioperative complications: a two-centre retrospective cohort study. Br J Anaesth. 2024 Sep; 133(3):628-636.von Wedel D, Redaelli S, Wachtendorf LJ, Ahrens E, Rudolph MI, Shay D, Chiarella LS, Suleiman A, Munoz-Acuna R, Ashrafian S, Seibold EL, Woloszynek S, Chen G, Talmor D, Banner-Goodspeed V, Eikermann M, Oriol NE, Schaefer MS. Br J Anaesth2024 Sep133(3):628-636http://www.ncbi.nlm.nih.gov/pubmed/37725759Intraoperative Use of Phenylephrine versus Ephedrine and Postoperative Delirium: A Multicenter Retrospective Cohort Study. Anesthesiology. 2024 Apr 01; 140(4):657-667.Ma H, Ahrens E, Wachtendorf LJ, Suleiman A, Shay D, Munoz-Acuna R, Tartler TM, Teja B, Wagner S, Subramaniam B, Rhee J, Schaefer MS. Anesthesiology2024 Apr 01140(4):657-667http://www.ncbi.nlm.nih.gov/pubmed/38000222Recovery and safety with prolonged high-frequency jet ventilation for catheter ablation of atrial fibrillation: A hospital registry study from a New England healthcare network. J Clin Anesth. 2024 05; 93:111324.Munoz-Acuna R, Tartler TM, Azizi BA, Suleiman A, Ahrens E, Wachtendorf LJ, Linhardt FC, Chen G, Tung P, Waks JW, Schaefer MS, Sehgal S. J Clin Anesth2024 0593:111324http://www.ncbi.nlm.nih.gov/pubmed/37957439Development and validation of an instrument to predict prolonged length of stay in the postanesthesia care unit following ambulatory surgery. Can J Anaesth. 2023 12; 70(12):1939-1949.Rupp S, Ahrens E, Rudolph MI, Azimaraghi O, Schaefer MS, Fassbender P, Himes CP, Anand P, Mirhaji P, Smith R, Freda J, Eikermann M, Wongtangman K. Can J Anaesth2023 1270(12):1939-1949http://www.ncbi.nlm.nih.gov/pubmed/37695139High Mechanical Power and Driving Pressures are Associated With Postoperative Respiratory Failure Independent From Patients' Respiratory System Mechanics. Crit Care Med. 2024 01 01; 52(1):68-79.Tartler TM, Ahrens E, Munoz-Acuna R, Azizi BA, Chen G, Suleiman A, Wachtendorf LJ, Costa ELV, Talmor DS, Amato MBP, Baedorf-Kassis EN, Schaefer MS. Crit Care Med2024 01 0152(1):68-79http://www.ncbi.nlm.nih.gov/pubmed/37639750The impact of residency training level on early postoperative desaturation: A retrospective multicenter cohort study. J Clin Anesth. 2023 11; 90:111238.Beier J, Ahrens E, Rufino M, Patel J, Azimaraghi O, Kumar V, Houle TT, Schaefer MS, Eikermann M, Wongtangman K. J Clin Anesth2023 1190:111238http://www.ncbi.nlm.nih.gov/pubmed/37380320Hyperventilation Before Apneic Oxygenation During Pulmonary Vein Isolation May Be Unnecessary and Potentially Harmful. JACC Clin Electrophysiol. 2023 06; 9(6):871.Schaefer MS, Ahrens E, Butler T. JACC Clin Electrophysiol2023 069(6):871http://www.ncbi.nlm.nih.gov/pubmed/37236317Intensity of one-lung ventilation and postoperative respiratory failure: A hospital registry study. Anaesth Crit Care Pain Med. 2023 10; 42(5):101250.Suleiman A, Azizi BA, Munoz-Acuna R, Ahrens E, Tartler TM, Wachtendorf LJ, Linhardt FC, Santer P, Chen G, Wilson JL, Gangadharan SP, Schaefer MS. Anaesth Crit Care Pain Med2023 1042(5):101250http://www.ncbi.nlm.nih.gov/pubmed/37024938Mechanical power and 30-day mortality in mechanically ventilated, critically ill patients with and without Coronavirus Disease-2019: a hospital registry study. J Intensive Care. 2023 Apr 06; 11(1):14.Azizi BA, Munoz-Acuna R, Suleiman A, Ahrens E, Redaelli S, Tartler TM, Chen G, Jung B, Talmor D, Baedorf-Kassis EN, Schaefer MS. J Intensive Care2023 Apr 0611(1):14http://www.ncbi.nlm.nih.gov/pubmed/36995964Association of Obstructive Sleep Apnea With Postoperative Delirium in Procedures of Moderate-to-High Complexity: A Hospital-Registry Study. Anesth Analg. 2024 Mar 01; 138(3):626-634.Wagner S, Ahrens E, Wachtendorf LJ, Suleiman A, Tartler TM, Shay D, Azimaraghi O, Munoz-Acuna R, Chen G, Ma H, Eikermann M, Schaefer MS. Anesth Analg2024 Mar 01138(3):626-634http://www.ncbi.nlm.nih.gov/pubmed/36798752Prevalence and association of non-medical cannabis use with post-procedural healthcare utilisation in patients undergoing surgery or interventional procedures: a retrospective cohort study. EClinicalMedicine. 2023 Mar; 57:101831.Ahrens E, Wachtendorf LJ, Chiarella LS, Ashrafian S, Suleiman A, Tartler TM, Azizi BA, Chen G, Berger AA, Shay D, Teja B, Banner-Goodspeed V, Ma H, Eikermann M, Hill KP, Schaefer MS. EClinicalMedicine2023 Mar57:101831http://www.ncbi.nlm.nih.gov/pubmed/36697936The association of intraoperative low driving pressure ventilation and nonhome discharge: a historical cohort study. Can J Anaesth. 2023 03; 70(3):359-373.Tartler TM, Wachtendorf LJ, Suleiman A, Blank M, Ahrens E, Linhardt FC, Althoff FC, Chen G, Santer P, Nagrebetsky A, Eikermann M, Schaefer MS. Can J Anaesth2023 0370(3):359-373http://www.ncbi.nlm.nih.gov/pubmed/36719955Loss of Independent Living in Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement: A Retrospective Cohort Study. Anesth Analg. 2023 09 01; 137(3):618-628.Blank M, Robitaille MJ, Wachtendorf LJ, Linhardt FC, Ahrens E, Strom JB, Azimaraghi O, Schaefer MS, Chu LM, Moon JY, Tarantino N, Nair SR, Thalappilil R, Tam CW, Leff J, Di Biase L, Eikermann M. Anesth Analg2023 09 01137(3):618-628http://www.ncbi.nlm.nih.gov/pubmed/36609226Cognitive function in older patients and their stress challenge using different anesthesia regimes: a single center observational study. BMC Anesthesiol. 2023 01 06; 23(1):6.Wagner S, Breitkopf M, Ahrens E, Ma H, Kuester O, Thomas C, von Arnim CAF, Walther A. BMC Anesthesiol2023 01 0623(1):6http://www.ncbi.nlm.nih.gov/pubmed/36564246Comparison of the effects of sugammadex versus neostigmine for reversal of neuromuscular block on hospital costs of care. Br J Anaesth. 2023 02; 130(2):133-141.Wachtendorf LJ, Tartler TM, Ahrens E, Witt AS, Azimaraghi O, Fassbender P, Suleiman A, Linhardt FC, Blank M, Nabel SY, Chao JY, Goriacko P, Mirhaji P, Houle TT, Schaefer MS, Eikermann M. Br J Anaesth2023 02130(2):133-141http://www.ncbi.nlm.nih.gov/pubmed/36535827Association of sugammadex reversal of neuromuscular block and postoperative length of stay in the ambulatory care facility: a multicentre hospital registry study. Br J Anaesth. 2023 03; 130(3):296-304.Azimaraghi O, Ahrens E, Wongtangman K, Witt AS, Rupp S, Suleiman A, Tartler TM, Wachtendorf LJ, Fassbender P, Choice C, Houle TT, Eikermann M, Schaefer MS. Br J Anaesth2023 03130(3):296-304http://www.ncbi.nlm.nih.gov/pubmed/36192221Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients. Br J Anaesth. 2023 02; 130(2):e298-e306.Ahrens E, Tartler TM, Suleiman A, Wachtendorf LJ, Ma H, Chen G, Kendale SM, Kienbaum P, Subramaniam B, Wagner S, Schaefer MS. Br J Anaesth2023 02130(2):e298-e306http://www.ncbi.nlm.nih.gov/pubmed/28865837Evaluation of scar quality after treatment of superficial burns of the hands and face with Dressilk or Biobrane-An intra-individual comparison. Burns. 2018 03; 44(2):305-317.Schiefer JL, Rath R, Ahrens E, Grigutsch D, Gräff I, Stromps JP, Fuchs PC, Schulz A. Burns2018 0344(2):305-317Emergence Delirium51.863109761339567e+0002022-10-01T00:00:002025-07-06T00:00:00Neuromuscular Nondepolarizing Agents31.233314030626488e+0002022-12-21T00:00:002025-12-04T00:00:00Neuromuscular Blockade41.219255233605582e+0002022-12-17T00:00:002025-12-04T00:00:00Anesthesia, General86.524259719393444e-0012023-01-06T00:00:002025-07-06T00:00:00Anesthesia35.303121638936241e-0012023-11-13T00:00:002024-12-01T00:00:00Delirium24.823275543226976e-0012024-11-04T00:00:002025-04-18T00:00:00Liver Transplantation24.727395537843833e-0012025-05-20T00:00:002025-06-24T00:00:00Postoperative Complications104.677564303603640e-0012022-10-01T00:00:002025-12-04T00:00:00Neostigmine34.645526512835765e-0012022-12-17T00:00:002025-04-18T00:00:00Respiratory Insufficiency44.387081499032206e-0012023-01-25T00:00:002024-07-04T00:00:00Surgical Procedures, Operative14.065164745782807e-0012025-06-16T00:00:002025-06-16T00:00:00Nervous System Diseases13.583159239402642e-0012022-10-01T00:00:002022-10-01T00:00:00Marijuana Use23.409159320737872e-0012024-12-01T00:00:002025-04-09T00:00:00Comorbidity13.324626619989526e-0012025-06-16T00:00:002025-06-16T00:00:00Sugammadex33.307365886635145e-0012022-12-17T00:00:002025-12-04T00:00:00Rocuronium22.842251189876348e-0012022-12-21T00:00:002025-12-04T00:00:00Respiration, Artificial62.822585570943474e-0012023-01-25T00:00:002024-08-26T00:00:00Hypotension22.724918239891167e-0012023-11-23T00:00:002024-04-01T00:00:00Intraoperative Complications22.665004095509652e-0012024-06-25T00:00:002024-09-19T00:00:00Registries62.515126845392681e-0012022-12-17T00:00:002025-04-18T00:00:00Massachusetts52.506434786923418e-0012024-07-26T00:00:002025-06-16T00:00:00Hypoxia32.457114212592240e-0012022-10-01T00:00:002024-11-04T00:00:00Hepatopulmonary Syndrome12.277057971192503e-0012025-06-24T00:00:002025-06-24T00:00:00S100 Calcium Binding Protein beta Subunit12.189702507989250e-0012024-11-04T00:00:002024-11-04T00:00:00Serotonin 5-HT3 Receptor Antagonists12.171960421328259e-0012024-08-01T00:00:002024-08-01T00:00:00Intraoperative Care22.138290026141166e-0012024-08-26T00:00:002025-07-06T00:00:00High-Frequency Jet Ventilation12.058265165879953e-0012023-11-23T00:00:002023-11-23T00:00:00Laryngeal Masks12.045957571670334e-0012024-09-19T00:00:002024-09-19T00:00:00Hyperventilation11.980561564940878e-0012023-06-01T00:00:002023-06-01T00:00:00One-Lung Ventilation11.953877000837994e-0012023-05-24T00:00:002023-05-24T00:00:00Hypocapnia11.922572580157642e-0012022-10-01T00:00:002022-10-01T00:00:00Respiration Disorders11.883662384894197e-0012025-12-04T00:00:002025-12-04T00:00:00Postoperative Cognitive Complications11.853891514738540e-0012023-01-06T00:00:002023-01-06T00:00:00Vena Cava, Inferior11.807872119113927e-0012025-05-20T00:00:002025-05-20T00:00:00Analgesics, Non-Narcotic11.678076850631185e-0012024-08-01T00:00:002024-08-01T00:00:00Airway Management11.666861395602168e-0012024-09-19T00:00:002024-09-19T00:00:00Marijuana Abuse11.635136969615276e-0012025-04-09T00:00:002025-04-09T00:00:00Sleep Apnea, Obstructive21.632456047215943e-0012023-03-30T00:00:002024-11-04T00:00:00Acetaminophen11.602715597320155e-0012024-08-01T00:00:002024-08-01T00:00:00Anesthesia, Conduction11.554628476201820e-0012023-01-06T00:00:002023-01-06T00:00:00Aged161.471190721235313e-0012022-10-01T00:00:002025-12-04T00:00:00Ketamine11.471162957774829e-0012025-07-06T00:00:002025-07-06T00:00:00Analgesics11.403978884401076e-0012025-07-06T00:00:002025-07-06T00:00:00Ambulatory Surgical Procedures11.401690356774740e-0012023-11-13T00:00:002023-11-13T00:00:00Cannabis11.387010807007885e-0012024-12-01T00:00:002024-12-01T00:00:00Cerebrovascular Disorders11.381736198670222e-0012025-04-09T00:00:002025-04-09T00:00:00Pulmonary Veins11.352677315228376e-0012023-06-01T00:00:002023-06-01T00:00:00Silk11.275312318160651e-0012017-08-31T00:00:002017-08-31T00:00:00Intubation, Intratracheal11.240484701563566e-0012024-09-19T00:00:002024-09-19T00:00:00Retrospective Studies111.209154075904320e-0012023-01-24T00:00:002025-12-04T00:00:00Bandages11.172101045972021e-0012017-08-31T00:00:002017-08-31T00:00:00Facial Injuries11.166350834591884e-0012017-08-31T00:00:002017-08-31T00:00:00Coated Materials, Biocompatible11.089664461069684e-0012017-08-31T00:00:002017-08-31T00:00:00Hand Injuries11.089274109070406e-0012017-08-31T00:00:002017-08-31T00:00:00Graft Survival11.062331047139138e-0012025-05-20T00:00:002025-05-20T00:00:00Humans301.061290903938932e-0012017-08-31T00:00:002025-12-04T00:00:00Transcatheter Aortic Valve Replacement11.036880340618487e-0012023-01-24T00:00:002023-01-24T00:00:00Postoperative Pain11.016036520735863e-0012024-08-01T00:00:002024-08-01T00:00:00Risk Assessment21.012047432415411e-0012025-04-18T00:00:002025-06-16T00:00:00Patient Selection19.417496870138252e-0022025-05-20T00:00:002025-05-20T00:00:00Anesthesia Recovery Period29.274650089048922e-0022022-12-17T00:00:002023-11-13T00:00:00Heart Valve Prosthesis Implantation19.193411933689101e-0022023-01-24T00:00:002023-01-24T00:00:00Middle Aged139.048669217762520e-0022017-08-31T00:00:002025-12-04T00:00:00Cicatrix18.786749537267699e-0022017-08-31T00:00:002017-08-31T00:00:00Hospital Mortality18.621443574725451e-0022025-06-16T00:00:002025-06-16T00:00:00Tidal Volume28.591383671459485e-0022023-05-24T00:00:002023-09-11T00:00:00Critical Illness18.538916990468516e-0022024-07-04T00:00:002024-07-04T00:00:00Health Care Costs18.449832115359528e-0022024-08-26T00:00:002024-08-26T00:00:00New England28.422711208325330e-0022023-09-11T00:00:002024-07-04T00:00:00Adult158.302070382865273e-0022017-08-31T00:00:002025-12-04T00:00:00Catheter Ablation18.247127088445205e-0022023-11-23T00:00:002023-11-23T00:00:00Respiratory Mechanics28.023997882158021e-0022023-09-11T00:00:002024-07-26T00:00:00Aortic Valve Stenosis17.943948828925999e-0022023-01-24T00:00:002023-01-24T00:00:00Patient Discharge17.706903064664043e-0022023-01-25T00:00:002023-01-25T00:00:00Aged, 80 and over27.546941853104289e-0022025-04-18T00:00:002025-06-16T00:00:00Liver17.447460401665935e-0022025-05-20T00:00:002025-05-20T00:00:00Male147.367623849729139e-0022017-08-31T00:00:002025-12-04T00:00:00Age Factors17.047423429128895e-0022025-04-18T00:00:002025-04-18T00:00:00Female146.973279316706156e-0022017-08-31T00:00:002025-12-04T00:00:00Analgesics, Opioid16.887642380677146e-0022024-08-01T00:00:002024-08-01T00:00:00Cohort Studies66.494916932920890e-0022023-01-25T00:00:002025-12-04T00:00:00Hospitals35.914188034609091e-0022022-12-17T00:00:002023-11-23T00:00:00Burns15.911437327084970e-0022017-08-31T00:00:002017-08-31T00:00:00Treatment Outcome45.911369416878447e-0022023-01-24T00:00:002025-07-06T00:00:00Risk Factors45.626280430060490e-0022023-01-24T00:00:002025-04-18T00:00:00Atrial Fibrillation15.509564413138895e-0022023-11-23T00:00:002023-11-23T00:00:00Ephedrine15.291973611901571e-0022024-04-01T00:00:002024-04-01T00:00:00Lung Compliance15.275432192212061e-0022024-07-26T00:00:002024-07-26T00:00:00COVID-1925.236652829223203e-0022024-07-04T00:00:002024-07-26T00:00:00Dose-Response Relationship, Drug25.086917950552872e-0022025-07-06T00:00:002025-12-04T00:00:00Phenylephrine14.983325113282969e-0022024-04-01T00:00:002024-04-01T00:00:00Internship and Residency14.852486002202553e-0022023-08-26T00:00:002023-08-26T00:00:00Hypertension, Portal14.794256419627577e-0022025-06-24T00:00:002025-06-24T00:00:00Postoperative Nausea and Vomiting14.447776516983693e-0022022-12-17T00:00:002022-12-17T00:00:00Hospitals, University14.386466504043569e-0022023-08-26T00:00:002023-08-26T00:00:00Cholinesterase Inhibitors14.153804515750423e-0022022-12-17T00:00:002022-12-17T00:00:00Lung34.104408737527564e-0022023-01-25T00:00:002024-07-26T00:00:00Respiratory System13.988965274699250e-0022023-09-11T00:00:002023-09-11T00:00:00Drug Interactions13.928895353325659e-0022024-08-01T00:00:002024-08-01T00:00:00Vasoconstrictor Agents13.906827125260129e-0022024-04-01T00:00:002024-04-01T00:00:00Anesthesiologists13.832813262337951e-0022024-06-25T00:00:002024-06-25T00:00:00Length of Stay23.709609695580630e-0022022-12-17T00:00:002023-11-13T00:00:00Cardiovascular Diseases13.677650852161672e-0022025-04-09T00:00:002025-04-09T00:00:00Independent Living13.531945289759139e-0022023-01-24T00:00:002023-01-24T00:00:00Hospital Costs13.147042984134895e-0022022-12-21T00:00:002022-12-21T00:00:00Equipment Design13.021072879965130e-0022024-09-19T00:00:002024-09-19T00:00:00Perioperative Care12.914780552551377e-0022024-08-26T00:00:002024-08-26T00:00:00ROC Curve12.897887049293078e-0022023-11-13T00:00:002023-11-13T00:00:00Esthetics12.880725454963872e-0022017-08-31T00:00:002017-08-31T00:00:00Elasticity12.871720075212593e-0022017-08-31T00:00:002017-08-31T00:00:00Spectrum Analysis12.864863084167291e-0022017-08-31T00:00:002017-08-31T00:00:00Heart Arrest12.722970699569917e-0022025-04-09T00:00:002025-04-09T00:00:00Drug Therapy, Combination12.670478974328742e-0022024-08-01T00:00:002024-08-01T00:00:00Hydrocortisone12.647341293924673e-0022023-01-06T00:00:002023-01-06T00:00:00Liver Cirrhosis12.636758956686886e-0022025-06-24T00:00:002025-06-24T00:00:00Odds Ratio12.503720112473002e-0022025-07-06T00:00:002025-07-06T00:00:00Patient Safety12.476734561664654e-0022024-09-19T00:00:002024-09-19T00:00:00Aortic Valve12.349381586159224e-0022023-01-24T00:00:002023-01-24T00:00:00Ambulatory Care12.201156398068940e-0022022-12-17T00:00:002022-12-17T00:00:00Logistic Models12.091514305463126e-0022025-07-06T00:00:002025-07-06T00:00:00Sex Factors12.013683819019140e-0022024-06-25T00:00:002024-06-25T00:00:00Prospective Studies21.834639596009078e-0022023-01-06T00:00:002024-11-04T00:00:00Severity of Illness Index11.630093387543935e-0022025-06-24T00:00:002025-06-24T00:00:00Wound Healing11.507548409711960e-0022017-08-31T00:00:002017-08-31T00:00:00Oxygen11.481608941568905e-0022017-08-31T00:00:002017-08-31T00:00:00Delivery of Health Care11.463591648048502e-0022023-11-23T00:00:002023-11-23T00:00:00Cognition11.375450875083977e-0022023-01-06T00:00:002023-01-06T00:00:00Pandemics11.349477517839490e-0022024-07-04T00:00:002024-07-04T00:00:00Myocardial Infarction11.334947901363992e-0022025-04-09T00:00:002025-04-09T00:00:00Skin11.269187969374416e-0022017-08-31T00:00:002017-08-31T00:00:00Biomarkers11.176345472324630e-0022024-11-04T00:00:002024-11-04T00:00:00Animals16.077147454464985e-0032025-06-24T00:00:002025-06-24T00:00:00Young Adult15.005696906577473e-0032017-08-31T00:00:002017-08-31T00:00:00William Cameron Aird, M.D.WilliamAird

Beth Israel Deaconess Med CtrDivision of Hem/Onc330 Brookline AveBoston, MA 02215617/667-103142.34022770000000-71.10585400000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineHematology/OncologyProfessor of MedicineFull ProfessorCo-Principal InvestigatorPathophysiology of the EndotheliumNIH1984-07-012015-06-30LUSCINSKAS, FRANCIS W.Inflammation is a key component of cardiovascular diseases and related pathophysiological processes, including atherosclerosis, autoimmunity, allograft rejection, the diabetes-metabolic syndrome, hemostasis and thrombosis, and wound healing. The vascular endothelium plays an active and vital role in regulating inflammatory responses and in maintaining homeostasis of the innate and adaptive immune systems. Two basic functions of the endothelium, particularly important in the context of inflammation, are the regulation of leukocyte recruitment and vascular permeability, both of which involve coordinated interactions of cell-cell adhesion/junctional molecules and the actin cytoskeleton. Dysregulation of these endothelial functions promotes inflammatory disease processes. Since its inception 30 years ago, this Program Project has combined cell and molecular biological, biochemical, morphological, molecular genetic, and experimental pathological approaches in in vitro cell culture and in vivo animal models to gain new insights into the active role of vascular endothelium in inflammation. In this amended renewal application, Project 1 will study the contribution of endothelial CD47 and its ligands Signal Regulatory Proteins and thrombospondin, as well as leukocyte CD47 dependent regulation of VLA-4 and LFA-1 integrin adhesion, in the recruitment of inflammatory mononuclear leukocytes into sites of chronic inflammation. Project 2 will examine the mechanisms by which endothelium selectively regulates recruitment of the IL17- and IFN-y producing subsets of T lymphocytes into tissues. Project 3 will determine how endothelial barrier function and leukocyte integrin-mediated adhesion may be selectively regulated by the subcellular compartmentalization of signaling by the intracellular mediator cAMP and its effectors molecules. In support of the scientific goals of these projects. Core A (Cell Biology) will provide well characterized vascular cell cultures (human, mouse, wildtype and mutant); monoclonal hybridoma cells and leukocyte cell lines; Core B (Morphology) will assist in immunohistochemistry and histopathology of mouse tissues; Core C (Physiological and Molecular Imaging) will support intravital and confocal microscopy studies as well as in vitro leukocyte-endothelial adhesion studies under defined flow conditions. Core D will provide administrative, secretarial and laboratory management support for the Program. The results of these proposed studies should yield valuable new insights into how vascular endothelial cells actively participate in the regulation of the inflammatory process, which is central to so many pathophysiological conditions that affect the heart and blood vessels (e.g., heart attacks and strokes), as well as other organs and tissues of the body. These mechanistic insights may help identify novel therapeutic targets for the treatment of a broad spectrum of inflammatory diseases.Principal InvestigatorVASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENENIH1998-07-012003-06-30AIRD, WILLIAM CThe development of the vascular system is dependent on a tightly regulated program beginning with the differentiation of endothelial cells from mesoderm, followed by their subsequent assembly into vascular channels, and ending with the establishment of organ and region-specific endothelial cell properties. Phenotypic diversity, which allows the endothelium to carry out specialized tasks according to the needs of the local environment, has been described at the level of cellular structure, function and antigen composition. However, the molecular pathways involved in establishing and maintaining these phenotypic patterns remain poorly defined. As one approach to this problem, we have focused on the mechanisms that govern regional differences in the expression of the von Willebrand factor (vWF) gene. We have shown in transgenic mice that distinct promoter elements of the human vWF gene direct expression to different vascular beds. Specifically, we have identified sequences within the 5' region and/or first intron that contain information for expression either within the blood vessels of the brain or microvessels of the heart. In addition, we have shown that transgene activation is mediated by signals residing in the extracellular milieu. These results raise the interesting possibility that vWF and perhaps other endothelial cell genes are differentially regulated by region-and organ-specific signaling pathways. The long range goals of this proposal are to elucidate the molecular basis of differential expression of the vWF gene. In the first two aims, we will characterize the DNA:protein interactions that mediate heart microvascular bed-specific expression of vWF. To delineate the putative transcriptional control elements, we will use screening strategies which take into account the potential role of environmental signals in modulating endothelial cell gene expression. These will include a combination of transgenic, co-culture and in vivo liposome- based transient transfection assays. We will then use a lambdagt11 or yeast-based screening system to clone the transcription factor that interacts specifically with these sequences. In the third and final aim, we will characterize the heart endothelial cell-specific transcriptional pathway in non-expressing vascular beds. We will reconstitute the signaling pathway under in vitro and in vivo conditions and determine the extent to which the transcriptional network is inducible in non-cardiac endothelial cells. Taken together, these studies should provide important information about the mechanisms of endothelial cell heterogeneity and vascular diversity.Co-Principal InvestigatorResearch Resource for Complex Physiologic SignalsNIH1999-09-032007-08-28GOLDBERGER, ARY LOUISThe NIH/NCRR Research Resource for Complex Physiologic Signals was established in September, 1999, in order to accelerate research progress and to stimulate new basic and clinical studies of biomedical signals. This competitive renewal request proposes to enhance and expand the components of this multidisciplinary Resource, including: PhysioBank - a large and growing archive of well-characterized digital recordings of physiologic signals and related data currently includes over 35 databases of cardiopulmonary, neural and other biomedical signals from healthy subjects and from patients with a variety of conditions with major public health implications, including sudden cardiac death, congestive heart failure, Parkinson's disease, sleep apnea, and aging. Core and collaborative research supporting this component develops new databases and specialized software to assist in this process. PhysioToolkit - a large and growing library of open source software for physiologic signal processing and analysis, detection of physiologically significant events using both classical techniques and novel methods based on statistical physics and nonlinear dynamics, interactive display and characterization of signals, creation of new databases, simulation of physiologic and other signals, evaluation and comparison of analysis methods, and analysis of complex processes. A unifying theme of research projects that contribute software to PhysioToolkit is the extraction of hidden information from biomedical signals, information that may have diagnostic or prognostic value in medicine, or explanatory or predictive power in basic research. PhysioNet - the Resource's web site (www.physionet.org) provides free access to PhysioBank and PhysioToolkit, and facilities for discussion and cooperative analysis of data and algorithms. PhysioNet offers a growing set of tutorials to assist in training investigators, clinicians and students in complex signal analysis. PhysioNet also hosts a highly successful series of open challenges that focus research efforts and promote rapid progress on important basic and clinical research questions. We also propose to develop new data analysis and archival biotechnology tools in support of the missions of the NCRR's General Clinical Research Centers, and to expand our core and collaborative research directed at a wide range of basic and clinical problems, including infant apnea, Parkinson's disease, and life-threatening cardiac arrhythmias.Principal InvestigatorENDOTHELIAL CELL SIGNALING AND CARDIAC ANGIOGENESISNIH2000-04-012005-03-31AIRD, WILLIAM CThe Specialized Center of Research (SCOR) in Ischemic Heart Disease will bring together faculty with clinical and basic science appointments at the Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) as well as Division of Health, Science and Technology (HST) and Department of Biology at the Massachusetts Institute of Technology. The Principal goal of this research is to lay down a foundation for new therapeutic approaches to the ischemic heart disease that will be at the core of our ability to design novel ways of stimulating collateral vessel growth in the diseased heart. Thus, the program combines basic, applied, and clinical research in vascular biology and molecular medicine. In addition, considerable emphasis is placed on the development of novel clinical and functional endpoints needed to assess the efficacy of angiogenic therapy. Recent investigations have conclusively demonstrated vascular bed- and milieu-specific regulation of endothelial cell function. Thus, there is every reason to expect that signaling events involved- both to and from endothelial cells are also vascular-bed and organ specific. Therefore, any investigation of endothelial cell signaling should be linked to the local context. With this concept in mind, three projects in this SCOR application are designed to assess endothelial cell signaling at several different levels. These include: 1) Identification and characterization of myocyte-derived stimulators of angiogenesis; 2) Molecular analysis of a novel syndecan-4-dependent signaling pathway in endothelial cells that is involved in mediation of bFGF-dependent angiogenesis; 3) The study of vascular bed-specific endothelial cell transcription. In combination, these projects provide a comprehensive approach to the role of endothelial cell diversity and inside-out as well outside-in signaling in regulation of local processes. The clinical project in this SCOR application addresses two fundamental issues in therapeutic application of this research- Development of effective local delivery strategies and characterization of novel clinical end-points that would be useful in large scale trials of angiogenic therapy. These projects are supported by Core laboratories that provide critical expertise in large and small bore magnetic resonance imaging and generation and evaluation of transgenic mice. Although our focus is primarily on cardiovascular applications, this program will provide broad biological insights into endothelial cell biology, angiogenesis and signal transduction that will be relevant to lung, blood and other diseases.Principal InvestigatorMOLECULAR BASIS OF CARDIAC-SPECIFIC HEMOSTASIS-COLLABORANIH2000-08-012006-07-31AIRD, WILLIAM CThe hemostatic balance is regulated by vascular bed-specific endothelial cell signaling pathways. We propose that coronary artery thrombosis arises through local alterations in one or more of these pathways. The overall goals of the Collaborative Program are to elucidate the molecular basis of endothelial cell subtype-specific gene expression in the heart and to identify the critical components of cardiac hemostasis. Dr. Rosenberg will study the role of a platelet-derived growth factor signaling pathway in mediating expression of a gene program within cardiac microvascular endothelial cells that includes tissue factor (TF). He will also optimize a recently developed mouse model of coronary artery thrombosis. Dr. Aird will examine the role of the Egr-1 transcription factor in mediating cardiac-specific hemostasis. He will ask how a single gene can serve to "fine tune" hemostasis according to the local needs of the tissue. Dr. Mackman will evaluate the role of a thrombin-PAR-1 signaling pathway in governing local levels of procoagulant (TF) and fibrinolytic (tissue-type plasminogen activator) molecules within the heart. In addition, he will address the contribution of monocyte-derived TF to cardiac hemostasis. Dr. Housman will use genetic approaches in large populations to identify genotypes which significantly contribute to coronary thrombosis. The three basic science projects (Projects 1-3) are interrelated by several common themes. Each component involves: (1) the study of a cardiac endothelial cell type-specific signaling pathway, (2) the determination of the effects of cell type-specific signaling pathways on global hemostasis (fibrin deposition) (3) the study of TF gene regulation and its role as the initiator of coagulation in the cardiac circulation, and (4) the use of transgenic mouse technology for studying vascular-bed specific hemostasis in the heart. The clinical project will serve as a vital link to validate the role of local hemostatic components in human populations. Dr. Rosenberg provides expertise in both genetic mouse models of hypercoagulability and in the functional analysis of in vivo hemostasis. Dr. Aird contributes tools for studying vascular bed-specific gene regulation. Dr. Mackman has experience in studying TF gene regulation in cultured cells and animal models. Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis.Principal InvestigatorTRANSCRIPTIONAL CONTROL OF CARDIAC-SPECIFIC HEMOSTASISNIH2000-08-012006-07-31AIRD, WILLIAM CThe hemostatic balance is regulated by vascular bed-specific endothelial cell signaling pathways. We propose that coronary artery thrombosis arises through local alterations in one or more of these pathways. The overall goals of the Collaborative Program are to elucidate the molecular basis of endothelial cell subtype-specific gene expression in the heart and to identify the critical components of cardiac hemostasis. Specific Aim 1) Dr. Rosenberg will study the role of a platelet-derived growth factor signaling pathway in mediating expression of a gene program within cardiac microvascular endothelial cells that includes tissue factor (TF). He will also optimize a recently developed mouse model of coronary artery thrombosis. Specific Aim 2) Dr. Aird will examine the role of the Egr-1 transcription factor in mediating cardiac-specific hemostasis. He will ask how a single gene can serve to "fine tune" hemostasis according to the local needs of the tissue. Specific Aim 3) Dr. Mackman will evaluate the role of a thrombin-PAR-1 signaling pathway in governing local levels of pro-coagulant (TF) and fibrinolytic (tissue-type plasminogen activator) molecules within the heart. In addition, he will address the contribution of monocyte-plasminogen activator) molecules within the heart. In addition, he will address the contribution of monocyte-derived TF to cardiac hemostasis. Specific Aim 4) Dr. Housman will use genetic approaches in large populations to identify genotypes which significantly contribute to coronary thrombosis. The three basic science projects Specific Aims 1-3) are interrelated by several common themes. Each component involves: (1) the study of a cardiac endothelial cell type-specific signaling pathway, (2) the determination of the effects of cell type-specific signaling pathways on global hemostasis (fibrin deposition), (3) the study of TF gene regulation and its role as the initiator of coagulation in the cardiac circulation, and (4) the use of transgenic mouse technology for studying vascular-bed specific hemostasis in the heart. The clinical project will serve as a vital link to validate the role of local hemostatic components in human populations. Dr. Rosenberg provides expertise in both genetic mouse models of hypercoagulability and in the functional analysis of in vivo hemostasis. Dr. Aird contributes tools for studying vascular gene-specific gene regulation. Dr. Mackman has experience in studying TF gene regulation in cultured cells and animal models. Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis.Principal InvestigatorModular Regulation of Genes within the EndotheliumNIH2003-09-302004-07-31AIRD, WILLIAM CEndothelial cell phenotypes display remarkable heterogeneity in health and disease. An important goal in vascular biology is to understand the molecular mechanisms underlying the spatial and temporal modulation of endothelial cell phenotypes. One approach to this problem is to delineate mechanisms of endothelial cell gene regulation. We have recently proposed a model of endothelial cell-specific gene expression that emphasis the importance of vascular bed-signaling pathways. According to this hypothesis, the expression of a single gene within the endothelium is regulated not by a common transcriptional control mechanism (or master switch), but rather by a constellation of site-specific pathways that begin in the extracellular environment and end at distinct regions of the promoter. The overall goal of this proposal is to map basal and inducible site-specific transcriptional modules in different organs (lung and brain) and different segments of the vascular tree (arteries and veins). This information will then be used to: 1) probe for mechanisms of endothelial cell heterogeneity, and 2) generate synthetic promoters for purposes of optimizing spatial and temporal control of gene expression. The primary focus of the first specific aim will be to delineate site-specific DNA elements of the human von Willebrand factor, Flt-1 and Tie-2 promoters. In addition, fate-mapping studies will be employed to track the longitudinal history of transgene expression over the lifetime of the animal. Two subsidiary studies will be carried out that address important questions relating to the interpretation of the results of transgenic assays and Hprt targeting, namely the degree to which the choice of reporter gene contributes to microheterogeneity, and the role of genetic background in determining the level and pattern of transgene expression. In the second specific aim, Hprt-targeted mice will be generated with synthetic endothelial cell-specific promoters that carry information for spatially- or temporally-restricted gene expression under normal conditions and in response to pathophysiological stimuli, including hypoxia and sepsis. Together, these studies will provide new insights into the modular control of endothelial cell gene expression and in doing so facilitate the development of selective gene targeting strategies in cardiovascular disease.Principal InvestigatorEndothelial Cell Phenotypes in Health and DiseaseNIH2004-07-012016-07-31AIRD, WILLIAM CVascular diseases are among the most common causes of morbidity and mortality in the Western world. A remarkable feature of these disorders is the local nature of their distribution; virtually all diseases are associated with focal pathological lesions in characteristic sites of the vascular tree. A key to understanding the mechanisms of focal vasculopathy is found within the endothelium. Endothelial cell (EC) phenotypes are differentially regulated in space and time. Phenotypic heterogeneity is governed largely at the level of gene expression. The integrating theme of this program is that cis-trans and epigenetics contribute to lineage determination and EC heterogeneity. The overall goal is to apply multidisciplinary approaches, including cutting-edge epigenetic assays, gene targeting, embryoid body differentiation assays, flow models and sepsis models to dissect the relative contribution of cis-trans and epigenetic forces in mediating lineage- and vascular bed-specific endothelial gene expression and phenotypes. The PPG integrates investigators with diverse expertise required to advance our understanding of gene regulation in the endothelium. Project 1 (Spatial and temporal dynamics of von Willebrand factor (vWF) gene expression; William C. Aird, Project Leader) focuses on molecular mechanisms governing vWF expression in health and disease. Project 2 (Transcriptional regulation of endothelial differentiation by ERG; Peter Oettgen, Project Leader) explores the role of the ETS transcription factor ERG in the regulation of EC differentiation, vascular development, and human endothelial progenitor cell function. Project 3 (Endothelial lineage diversity: role of epigenetics; Philip Marsden, Project Leader) examines the role of epigenetic forces in mediating endothelial cell-specific gene expression of eNOS. Core A (Administrative Support; William C. Aird, Core Leader) provides standard administrative support, including the coordination of all applicable statutory compliance, for the Program. Core B (Epigenetics Core; John Whetstine, Core Leader) provides expertise and technical support for studying epigenetic modification of endothelial genes. Core C (Gene Targeting Core; William C. Aird, Core Leader) provides the necessary tools for targeting the Hprt locus and the loci of endogenous genes in ES cells and mice.Principal InvestigatorForkhead signaling in the endotheliumNIH2004-07-012015-09-30AIRD, WILLIAM CEndothelial cell (EC) phenotypes display remarkable heterogeneity in health and disease. An important goal in vascular biology is to understand the molecular mechanisms underlying the spatial and temporal modulation of EC phenotypes. This competing renewal application is an extension of our previous work aimed towards elucidating the role of forkhead (FOXO) transcription factors in EC biology. Three novel and exciting aspects of FOXO biology have emerged in the past 3 years, which together with our own published data and preliminary results provide a strong foundation for the current proposal: 1) despite the fact that FOXO proteins are ubiquitously expressed, FOXO- deficient mice display a vascular phenotype, whether the gene is deleted during embryogenesis or in adults, 2) the vascular phenotype is organ-specific and FOXO-deficient ECs from different organs demonstrate different gene expression patterns and functional changes, and 3) FOXO proteins (at least in other cell types) have been shown to bind to and/or interact with a broad spectrum of transcription factors. Based on these considerations, we hypothesize that FOXO proteins (in particular FOXO1) cooperate with other transcription factors to regulate EC phenotypes. The overall goal is to identify FOXO1-associated transcriptional networks in ECs, to understand how these mediate vascular bed-specific gene expression, and to define the in vivo role of FOXO1 in the intact endothelium. Aim 1 is to characterize functional interactions between FOXO1 and other transcription factors in ECs. Aim 2 is to characterize combinatorial gene regulation by FOXO1 and NF-kB in ECs. Aim 3 is to analyze the effect of conditional FOXO1 over-expression and knockout on EC function and dysfunction in normal and pathological states.Principal Investigator2004 Endothelial Cell Phenotypes in Health &DiseaseNIH2004-07-012005-06-30AIRD, WILLIAM CThe endothelium, in traversing each and every organ, establishes a dialogue that is unique to the underlying tissue. The endothelial-tissue interface plays an important role not only in maintaining health of the organism, but also in dictating the focal nature of vascular disease states. Viewed from this perspective, the endothelium transcends all clinical disciplines. While twenty years ago, one was hard pressed to identify a single disease in which the endothelium played a prominent role, today, it may be argued that virtually every disease involves the endothelium, either as a primary determinant of disease or as a victim of collateral damage. At the present time, the field is lacking a formal venue for interdisciplinary interactions. To overcome this limitation, we have initiated a new Gordon Research Conference (GRC), entitled: "Endothelial Cell Phenotypes in Health and Disease". The inaugural conference will be held at Proctor Academy, NH, August 22-27, 2004. The overall goal of this conference is to bring together scientists from diverse fields with a common interest in understanding the role of endothelial cell phenotypes in health and disease. The fields include Darwinian medicine, history of medicine, non-linear dynamics, genomics, proteomics, hematology, oncology, pulmonary, cardiology, developmental biology, dermatology, placental biology, gastroenterology, neurosciences nephrology, transplant biology, stem cell biology and diabetes. The aims of this conference are to: 1) provide a forum for direct and intense discussion in a vital and emerging area, 2) discuss the mechanisms that mediate phenotypic heterogeneity of the endothelium, 3) apply these considerations to an understanding of vascular disease states, and 4) encourage new avenues of research and development. This R13 application is a request for partial funding of the first GRC on Endothelial Cell Phenotypes in Health and Disease in 2004. Principal InvestigatorVEGF, Transcriptional Networks and Vascular InflammationNIH2007-01-192010-12-31AIRD, WILLIAM CVascular endothelial growth factor (VEGF) is an endothelial cell (EC)-specific mitogen, and chemotactic agent, which is involved in wound repair, angiogenesis of ischemic tissue, tumor growth, microvascular permeability, vascular protection, and hemostasis. Over the past several years, there has been a major thrust towards developing therapies that either decrease VEGF levels or activity (e.g. Avastin in cancer), or increase VEGF (e.g. gene delivery strategies in ischemic heart disease). At the same time, there is increasing evidence that VEGF plays a role in modulating inflammation and coagulation. VEGF may alter EC phenotype through transcriptional and/or post-transcriptional mechanisms. Among the transcription factors that have been implicated in VEGF signaling are NF-kB, Egr-1, NF-AT, and GATA. The overall goal of this proposal is to identify the transcriptional mechanisms that underlie VEGF signaling in inflammation and coagulation. The first aim will explore mechanisms by which VEGF induces expression of VCAM-1 and ICAM-1. In the second aim, siRNA and dominant negative approaches will be employed to map links between VEGF-responsive transcription factors and target gene expression/cellular function. The third aims is dedicated to an in vivo analysis of VEGF-responsive transcriptional networks in health and disease, with a particular emphasis on sepsis. A more complete understanding of the transcriptional mechanisms by which VEGF is coupledto endothelial cell phenotype should provide a framework for tailoring and fine tuning therapeutic modalities in vascular disease states.Principal InvestigatorDownstream of Akt in the tumor vesselNIH2008-07-012014-05-31AIRD, WILLIAM CSummary: We have found that Akt signaling contributes to some of the more notable abnormalities in tumor vascular stroma. Vascular abnormalities include the propensity for excessive vascular permeability leading to tissue edema and sluggish blood flow, extravasation of fibrin and other matrix proteins that alter the extracellular microenvironment, and the trafficking of inflammatory cells and tumor cells in and out of the tumor-associated vasculature. Our overall hypothesis is the same signaling pathways that govern chronic permeability also govern leukocyte extravasation and tumor cell extravasation. Thus in this application we are testing this hypothesis in the following 3 aims. Aim 1 Test the hypothesis that inactivation GSK3 mediates Akt-driven baseline permeability and explores the signaling pathway from Akt to mTOR that contributes to angiogenesis and vascular permeability and the signaling that alters GSK3 phosphorylation in endothelial cell and tumor cells Aim 2: To explore the role of Akt and downstream signaling pathways on cellular trafficking of leukocytes and tumor cells across the endothelium. Aim 3: Test the hypothesis that Akt effects on chronic permeability, leukocyte adhesion and diapedesis and tumor cell metastasis are mediated through Akt inactivation of GSK3 and subsequent Snail repression of VE-cadherin. Disease Relevance: The overall goal of my laboratory is to study the integration of signaling pathways that control angiogenesis and microvascular function. No one project can study all pathways at once, but the current focus of the lab is on the Akt signaling pathway, how it is regulated and how it regulates microvascular formation and function. In addition to exploring molecular mechanisms, we also study clinically feasible approaches to target this pathway. This application is proposing to explore some of the downstream signaling pathways that mediate the effects of endothelial Akt signaling in pathological angiogenesis, including cancer. While Akt pathway inhibitors are under development, most of the cancer studies that utilize those inhibitors are focused on the inhibition of tumor cell signaling. We have found that the vascular response to rapamycin is an important part of that Akt pathway inhibitor's efficacy in preclinical models. Our hope for this project is that by carefully examining the mediators of Akt's function in pathological angiogenesis we can uncover novel stromal targets to expand the repertoire of cancer therapeutics. In addition, we hope to significantly aid in the progress towards an effective use of existing Akt pathway inhibitors in cancer by exploring the understudied stromal effects of this pathway. We anticipate our findings to be relevant not only to the management of tumor progression but to have particular applications in preventing metastasisPrincipal InvestigatorRole of VEGF and PlGF signaling in sepsisNIH2009-09-152011-08-31AIRD, WILLIAM CWe have shown that circulating levels of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are elevated in mouse and human models of sepsis, that VEGF plays a pathogenic role in sepsis, and that the upregulation of PlGF represents an adaptive host response that protects against sepsis morbidity and mortality. To our knowledge, these data are the first to demonstrate any physiological role for PlGF. In spite of the protective role of PlGF in sepsis, mice carrying a tyrosine kinase-deficient VEGFR1/Flt-1 receptor displayed reduced endotoxin-mediated mortality. Based on these findings we hypothesize that a finely tuned balance between VEGF and PlGF signaling is central to the host response and that an imbalance leads to pathophysiology. The overall goal is to understand how VEGF and PlGF signaling is coordinated during the host innate immune response. Aim 1 is delineate the role of VEGF in the host response to infection. In the revised application (for the two-year ARRA award), we have refocused our studies in Aim 1 to measure VEGFA isoform expression in animal models of sepsis, determine the role of VEGF-B in animal models of sepsis and to generate Hprt-targeted mice with inducible over-expression of VEGF, VEGFR1, VEGFR2 and sVEGFR1. Aim 2 is to delineate the role of PlGF in the host response to infection. In the revised application, Aim 2 focuses specifically on the role of VEGFR1 and PlGF-VEGF heterodimers in sepsis.Principal InvestigatorMechanisms of Mosaic Heterogeneity in EndotheliumNIH2015-07-012021-04-30AIRD, WILLIAM C? DESCRIPTION (provided by applicant): Endothelial cells (ECs) display marked phenotypic heterogeneity in structure and function, in time and space and in health and disease. Phenotypes differ between: 1) different segments of the vasculature (i.e., artery vs. vein vs. capillary); 2) different organs (i.e., lung capillary vs. heart capillary); and 3) neighboring cell (so-called mosaic heterogeneity). The mechanisms underlying the first two types of heterogeneity involve a combination of site-specific environmental signals (nurture) and vascular bed-specific epigenetic programs (nature). However, such mechanisms do not adequately explain mosaic heterogeneity of the endothelium, where phenotypically distinct neighbors have near-identical histories and environments. Mosaics of mutually exclusive phenotypes are observed across all domains of life. They are believed to arise from multistable regulatory circuits that are sensitive to biological noise. We propose that the normal endothelium leverages intrinsic noise-driven mosaic heterogeneity as a means of responding to opposing environmental demands with flexibility and speed. This ability to enhance its response repertoire (and hedge its bets) may be compromised in diseased or dysfunctional endothelium. The objective of this proposal is to use a combination of experimentation and modeling to delineate the mechanisms that govern mosaic heterogeneity of the endothelial-restricted procoagulant, von Willebrand factor (VWF), and to understand the adaptive significance of this phenomenon. We have shown that VWF expression is expressed in a minority of capillary ECs in heart, skeletal muscle, lung and brain and that this mosaic pattern is dynamically regulated. We have also observed dynamic mosaic heterogeneity of VWF in cultured primary human ECs. Surprisingly, we found that the bistable switch responsible for mosaic VWF expression involves noise-sensitive DNA methylation of the VWF promoter. Finally, and most importantly, our preliminary data indicate that the absence of mosaic VWF expression in the heart leads to profound endothelial damage. Based on these findings, we hypothesize that organ-specific mosaic heterogeneity of VWF is mediated by a cell-autonomous, bistable DNA methylation switch, whose sensitivity to noise is modulated by its extracellular and intracellular environment. We further hypothesize that mosaic VWF heterogeneity is required for cardiac health. Our goal is to measure, model and predict the behavior of this switch and to delineate the mechanisms by which mosaic heterogeneity promotes cardiac health. We propose three specific aims. In the first aim, we will delineate the role of biological noise in generating VWF mosaic heterogeneity. In the second aim, we will delineate the molecular basis of the bistable switch underlying VWF mosaic heterogeneity. In the third aim, we will delineate the role of VWF mosaic heterogeneity in cardiac health. The project is significant because it establishes a foundation for testing the hypothesis that dynamic mosaic heterogeneity of the endothelium provides a means for tunable, organ-specific bet hedging. Such behavior has important therapeutic implications for treating vascular diseases.Principal Investigator19th International Vascular Biology MeetingNIH2016-06-012017-05-31AIRD, WILLIAM C? DESCRIPTION (provided by applicant): The International Vascular Biology Meeting (IVBM) is a time-honored biannual event that provides a unique opportunity for the exchange, update, and discussion of timely vascular biology research by the global community. The meeting, which began 41 years ago, rotates between Europe, Australia, Asia and North America. The last meeting took place in Kyoto, Japan in 2014. The most recent USA meeting was in 2010. Six years later, the USA is once again charged with organizing IVBM. Following a call for sites, the North American Vascular Biology Organization (NAVBO) appointed a special selection committee, which chose Boston based on the combined features of accessibility of the location, well established infrastructure, and breadth of expertise of the organizing committee. The meeting will take place October 30 to November 3 at the Sheraton Boston Hotel. The scientific program was developed by a Local Organizing Committee with extensive input from a 65-member International Scientific Program Committee. The program includes 39 scientific sessions with nearly 80 invited speakers, including a significant number of women and junior investigators. It will cover a broad spectrum of vascular biology prioritizing the emerging areas of contemporary vascular biology research. As such, it aims at serving as an integrative hub bridging and cross-fertilizing the different branches of the vascular biology field. Towards this end, the program will incorporate different presentation formats including plenary sessions, simultaneous sessions, workshops, and poster sessions. The meeting has been tailored to attract the next generation of young vascular biologists by including oral presentations selected from the abstracts and Meet-the-Professor discussion groups. Additional incentives for young attendees include travel awards and the abundance of inexpensive airfares to Boston from both national and international airports. NIH support is essential for the success of this opportunity fr the USA to host the premier scientific meeting of the international vascular biology community. Narrative: The International Vascular Biology Meeting provides a forum for trainees and principle investigators from around the world to exchange knowledge about cutting edge research in vascular biology. It also provides attendees with an opportunity to interact with each other in non-didactic formats with the goal of providing/receiving career advice and fostering new collaborations. By promoting information sharing on multiple levels, the meeting should lead to the development of novel and improved strategies for treatment of vascular pathologies and other pathologies with vascular involvement in a broad context.http://www.ncbi.nlm.nih.gov/pubmed/41055630Icefish: Peculiar Creatures Without Hemoglobin or Red Blood Cells. Mayo Clin Proc. 2025 Nov; 100(11):2039-2042.Steensma DP, Aird WC. Mayo Clin Proc2025 Nov100(11):2039-2042http://www.ncbi.nlm.nih.gov/pubmed/41112877Form Follows Function: Introducing a Comparative Hematology Course into the Post-Clerkship Phase of Medical School. Med Sci Educ. 2025 Aug; 35(4):1893-1899.Kometas ML, Raman G, Adkins BD, Rambally S, Hofmann SL, Aird WC, Bavli N. Med Sci Educ2025 Aug35(4):1893-1899http://www.ncbi.nlm.nih.gov/pubmed/38987596Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. 2024 Jul; 631(8021):645-653.Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann WA, Guo C, Piontek G, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Aird WC, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S. Nature2024 Jul631(8021):645-653http://www.ncbi.nlm.nih.gov/pubmed/34525794Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo. Haematologica. 2022 07 01; 107(7):1669-1680.Nicolai L, Kaiser R, Escaig R, Hoffknecht ML, Anjum A, Leunig A, Pircher J, Ehrlich A, Lorenz M, Ishikawa-Ankerhold H, Aird WC, Massberg S, Gaertner F. Haematologica2022 07 01107(7):1669-1680http://www.ncbi.nlm.nih.gov/pubmed/32988649New Uses for Thromboelastography and Other Forms of Viscoelastic Monitoring in the Emergency Department: A Narrative Review. Ann Emerg Med. 2021 03; 77(3):357-366.Tyler PD, Yang LM, Snider SB, Lerner AB, Aird WC, Shapiro NI. Ann Emerg Med2021 0377(3):357-366http://www.ncbi.nlm.nih.gov/pubmed/32766883Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood. 2020 09 10; 136(11):1342-1346.Patell R, Bogue T, Koshy A, Bindal P, Merrill M, Aird WC, Bauer KA, Zwicker JI. Blood2020 09 10136(11):1342-1346http://www.ncbi.nlm.nih.gov/pubmed/32692862Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19. J Thromb Haemost. 2020 09; 18(9):2349-2357.Patell R, Bogue T, Bindal P, Koshy A, Merrill M, Aird WC, Bauer KA, Zwicker JI. J Thromb Haemost2020 0918(9):2349-2357http://www.ncbi.nlm.nih.gov/pubmed/32658337Heparin induced thrombocytopenia antibodies in Covid-19. Am J Hematol. 2020 Oct; 95(10):E295-E296.Patell R, Khan AM, Bogue T, Merrill M, Koshy A, Bindal P, Joyce R, Aird WC, Neuberg D, Bauer KA, Zwicker JI. Am J Hematol2020 Oct95(10):E295-E296http://www.ncbi.nlm.nih.gov/pubmed/31996458Epigenetic Heterogeneity and Mitotic Heritability Prime Endothelial Cell Gene Induction. J Immunol. 2020 03 01; 204(5):1173-1187.Turgeon PJ, Chan GC, Chen L, Jamal AN, Yan MS, Ho JJD, Yuan L, Ibeh N, Ku KH, Cybulsky MI, Aird WC, Marsden PA. J Immunol2020 03 01204(5):1173-1187http://www.ncbi.nlm.nih.gov/pubmed/31712416The in vivo endothelial cell translatome is highly heterogeneous across vascular beds. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23618-23624.Cleuren ACA, van der Ent MA, Jiang H, Hunker KL, Yee A, Siemieniak DR, Molema G, Aird WC, Ganesh SK, Ginsburg D. Proc Natl Acad Sci U S A2019 11 19116(47):23618-23624http://www.ncbi.nlm.nih.gov/pubmed/30211758Leukocyte Transcriptional Response in Sepsis. Shock. 2019 08; 52(2):166-173.Skibsted S, Bhasin MK, Henning DJ, Jaminet SC, Lewandowski J, Kirkegaard H, Aird WC, Shapiro NI. Shock2019 0852(2):166-173http://www.ncbi.nlm.nih.gov/pubmed/30984439Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient. Case Rep Transplant. 2019; 2019:3682378.Yang D, Thamcharoen N, Marcus C, Varkaris A, Aird W, Khankin EV, Cardarelli F. Case Rep Transplant20192019:3682378http://www.ncbi.nlm.nih.gov/pubmed/30665023Endothelial cells of different organs exhibit heterogeneity in von Willebrand factor expression in response to hypoxia. Atherosclerosis. 2019 03; 282:1-10.Mojiri A, Alavi P, Lorenzana Carrillo MA, Nakhaei-Nejad M, Sergi CM, Thebaud B, Aird WC, Jahroudi N. Atherosclerosis2019 03282:1-10http://www.ncbi.nlm.nih.gov/pubmed/30510113The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation. J Cell Sci. 2019 01 02; 132(1).Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y. J Cell Sci2019 01 02132(1)http://www.ncbi.nlm.nih.gov/pubmed/30458880Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care. 2018 Nov 20; 22(1):308.Massey MJ, Hou PC, Filbin M, Wang H, Ngo L, Huang DT, Aird WC, Novack V, Trzeciak S, Yealy DM, Kellum JA, Angus DC, Shapiro NI. Crit Care2018 Nov 2022(1):308http://www.ncbi.nlm.nih.gov/pubmed/30268146In vivo quantification of rolling and adhered leukocytes in human sepsis. Crit Care. 2018 09 30; 22(1):240.Fabian-Jessing BK, Massey MJ, Filbin MR, Hou PC, Wang HE, Kirkegaard H, Yealy DM, Aird WC, Kellum JA, Angus DC, Shapiro NI. Crit Care2018 09 3022(1):240http://www.ncbi.nlm.nih.gov/pubmed/29734527Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: reply. J Thromb Haemost. 2018 07; 16(7):1454-1456.Beeler DL, Aird WC, Grant MA. J Thromb Haemost2018 0716(7):1454-1456http://www.ncbi.nlm.nih.gov/pubmed/29618782ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation. Sci Rep. 2018 04 04; 8(1):5653.Tanaka T, Izawa K, Maniwa Y, Okamura M, Okada A, Yamaguchi T, Shirakura K, Maekawa N, Matsui H, Ishimoto K, Hino N, Nakagawa O, Aird WC, Mizuguchi H, Kawabata K, Doi T, Okada Y. Sci Rep2018 04 048(1):5653http://www.ncbi.nlm.nih.gov/pubmed/29418058Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey. J Thromb Haemost. 2018 04; 16(4):734-748.Beeler DL, Aird WC, Grant MA. J Thromb Haemost2018 0416(4):734-748http://www.ncbi.nlm.nih.gov/pubmed/29137978Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation. Biochem Biophys Res Commun. 2018 01 01; 495(1):801-806.Shirakura K, Ishiba R, Kashio T, Sakai M, Fukushima Y, Yamamoto N, Manabe S, Shigesada N, Tanaka T, Hino N, Aird WC, Doi T, Okada Y. Biochem Biophys Res Commun2018 01 01495(1):801-806http://www.ncbi.nlm.nih.gov/pubmed/28899852Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis. Blood. 2017 12 07; 130(23):2548-2558.Grant MA, Beeler DL, Spokes KC, Chen J, Dharaneeswaran H, Sciuto TE, Dvorak AM, Interlandi G, Lopez JA, Aird WC. Blood2017 12 07130(23):2548-2558http://www.ncbi.nlm.nih.gov/pubmed/28109962Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial. Chest. 2017 07; 152(1):22-31.Hou PC, Filbin MR, Wang H, Ngo L, Huang DT, Aird WC, Yealy DM, Angus DC, Kellum JA, Shapiro NI. Chest2017 07152(1):22-31http://www.ncbi.nlm.nih.gov/pubmed/28381804Tumor Necrosis Factor a Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-?B Pathway. Biol Pharm Bull. 2017; 40(4):504-509.Tanaka T, Maekawa N, Kashio T, Izawa K, Ishiba R, Shirakura K, Ishimoto K, Hino N, Aird WC, Doi T, Okada Y. Biol Pharm Bull201740(4):504-509http://www.ncbi.nlm.nih.gov/pubmed/27183587Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin. J Immunol. 2016 06 01; 196(11):4681-91.Moser J, Heeringa P, Jongman RM, Zwiers PJ, Niemarkt AE, Yan R, de Graaf IA, Li R, Ravasz Regan E, Kümpers P, Aird WC, van Nieuw Amerongen GP, Zijlstra JG, Molema G, van Meurs M. J Immunol2016 06 01196(11):4681-91http://www.ncbi.nlm.nih.gov/pubmed/26979940Principles of dynamical modularity in biological regulatory networks. Sci Rep. 2016 Mar 16; 6:21957.Deritei D, Aird WC, Ercsey-Ravasz M, Regan ER. Sci Rep2016 Mar 166:21957http://www.ncbi.nlm.nih.gov/pubmed/26744078A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nat Commun. 2016 Jan 08; 7:10160.Yuan L, Chan GC, Beeler D, Janes L, Spokes KC, Dharaneeswaran H, Mojiri A, Adams WJ, Sciuto T, Garcia-Cardeña G, Molema G, Kang PM, Jahroudi N, Marsden PA, Dvorak A, Regan ER, Aird WC. Nat Commun2016 Jan 087:10160http://www.ncbi.nlm.nih.gov/pubmed/26719538VEGF-A/VEGFR Inhibition Restores Hematopoietic Homeostasis in the Bone Marrow and Attenuates Tumor Growth. Cancer Res. 2016 Feb 01; 76(3):517-24.O'Donnell RK, Falcon B, Hanson J, Goldstein WE, Perruzzi C, Rafii S, Aird WC, Benjamin LE. Cancer Res2016 Feb 0176(3):517-24http://www.ncbi.nlm.nih.gov/pubmed/26459591Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):987-91.Okada Y, Naruse H, Tanaka T, Funahashi N, Regan ER, Yamakawa K, Hino N, Ishimoto K, Doi T, Aird WC. Biochem Biophys Res Commun2015 Nov 27467(4):987-91http://www.ncbi.nlm.nih.gov/pubmed/25855898Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med. 2015 Jul; 43(7):e230-40.Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM. Crit Care Med2015 Jul43(7):e230-40http://www.ncbi.nlm.nih.gov/pubmed/25666572Endothelium and haemostasis. Hamostaseologie. 2015; 35(1):11-6.Aird WC. Hamostaseologie201535(1):11-6http://www.ncbi.nlm.nih.gov/pubmed/25009290PGC-1a induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15; 115(5):504-17.Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z. Circ Res2014 Aug 15115(5):504-17http://www.ncbi.nlm.nih.gov/pubmed/24874427FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014 Jul 07; 115(2):238-251.Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler D, Spokes KC, Janes L, Sciuto T, Kang PM, Jaminet SS, Dvorak A, Grant MA, Regan ER, Aird WC. Circ Res2014 Jul 07115(2):238-251http://www.ncbi.nlm.nih.gov/pubmed/24855053Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1531-8.Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T. Arterioscler Thromb Vasc Biol2014 Jul34(7):1531-8http://www.ncbi.nlm.nih.gov/pubmed/24313705Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Am J Respir Cell Mol Biol2014 May50(5):876-81http://www.ncbi.nlm.nih.gov/pubmed/24246501Plasmodium falciparum picks (on) EPCR. Blood. 2014 Jan 09; 123(2):163-7.Aird WC, Mosnier LO, Fairhurst RM. Blood2014 Jan 09123(2):163-7http://www.ncbi.nlm.nih.gov/pubmed/24093155Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care. 2013 Oct 04; 17(5):231.Skibsted S, Bhasin MK, Aird WC, Shapiro NI. Crit Care2013 Oct 0417(5):231http://www.ncbi.nlm.nih.gov/pubmed/23848403RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins. J Thromb Haemost. 2013 Sep; 11(9):1742-50.Okada Y, Watanabe M, Nakai T, Kamikawa Y, Shimizu M, Fukuhara Y, Yonekura M, Matsuura E, Hoshika Y, Nagai R, Aird WC, Doi T. J Thromb Haemost2013 Sep11(9):1742-50http://www.ncbi.nlm.nih.gov/pubmed/24052946Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13.Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Stem Cell Reports20131(2):105-13http://www.ncbi.nlm.nih.gov/pubmed/23825515Correction: Overexpression of MyrAkt1 in Endothelial Cells Leads to Erythropoietin- and BMP4-Independent Splenic Erythropoiesis in Mice. PLoS One. 2013; 8(6).O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC. PLoS One20138(6)http://www.ncbi.nlm.nih.gov/pubmed/23809110Evolutionary origins of the blood vascular system and endothelium. J Thromb Haemost. 2013 Jun; 11 Suppl 1:46-66.Monahan-Earley R, Dvorak AM, Aird WC. J Thromb Haemost2013 Jun11 Suppl 1:46-66http://www.ncbi.nlm.nih.gov/pubmed/23723450Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood. 2013 Jul 18; 122(3):443-55.Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Blood2013 Jul 18122(3):443-55http://www.ncbi.nlm.nih.gov/pubmed/23524845Biomarkers of endothelial cell activation in early sepsis. Shock. 2013 May; 39(5):427-32.Skibsted S, Jones AE, Puskarich MA, Arnold R, Sherwin R, Trzeciak S, Schuetz P, Aird WC, Shapiro NI. Shock2013 May39(5):427-32http://www.ncbi.nlm.nih.gov/pubmed/23563632The flow dependency of Tie2 expression in endotoxemia. Intensive Care Med. 2013 Jul; 39(7):1262-71.Kurniati NF, Jongman RM, vom Hagen F, Spokes KC, Moser J, Regan ER, Krenning G, Moonen JR, Harmsen MC, Struys MM, Hammes HP, Zijlstra JG, Aird WC, Heeringa P, Molema G, van Meurs M. Intensive Care Med2013 Jul39(7):1262-71http://www.ncbi.nlm.nih.gov/pubmed/23529929Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium. Blood. 2013 May 23; 121(21):4404-12.Yuan L, Janes L, Beeler D, Spokes KC, Smith J, Li D, Jaminet SC, Oettgen P, Aird WC. Blood2013 May 23121(21):4404-12http://www.ncbi.nlm.nih.gov/pubmed/23449636A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood. 2013 Apr 25; 121(17):3531-40.Shirodkar AV, St Bernard R, Gavryushova A, Kop A, Knight BJ, Yan MS, Man HS, Sud M, Hebbel RP, Oettgen P, Aird WC, Marsden PA. Blood2013 Apr 25121(17):3531-40http://www.ncbi.nlm.nih.gov/pubmed/23446734The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood. 2013 Apr 18; 121(16):3205-15.Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, Ryeom S. Blood2013 Apr 18121(16):3205-15http://www.ncbi.nlm.nih.gov/pubmed/23365463Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody. Blood. 2013 Apr 04; 121(14):2804-13.Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Blood2013 Apr 04121(14):2804-13http://www.ncbi.nlm.nih.gov/pubmed/23383068Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice. PLoS One. 2013; 8(1):e55095.O'Donnell RK, Goldstein WE, Perruzzi C, Benjamin LE, Aird WC. PLoS One20138(1):e55095http://www.ncbi.nlm.nih.gov/pubmed/22932696Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis. Development. 2012 Nov; 139(21):3973-85.Vijayaraj P, Le Bras A, Mitchell N, Kondo M, Juliao S, Wasserman M, Beeler D, Spokes K, Aird WC, Baldwin HS, Oettgen P. Development2012 Nov139(21):3973-85http://www.ncbi.nlm.nih.gov/pubmed/22723222Dynamical systems approach to endothelial heterogeneity. Circ Res. 2012 Jun 22; 111(1):110-30.Regan ER, Aird WC. Circ Res2012 Jun 22111(1):110-30http://www.ncbi.nlm.nih.gov/pubmed/22608986Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med. 2012 Jul; 125(7):670-8.Schuetz P, Kennedy M, Lucas JM, Howell MD, Aird WC, Yealy DM, Shapiro NI. Am J Med2012 Jul125(7):670-8http://www.ncbi.nlm.nih.gov/pubmed/22258235Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8.van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Shock2012 Apr37(4):392-8http://www.ncbi.nlm.nih.gov/pubmed/22373634From hagfish to humans: teaching comparative physiology to internal medicine residents. Acad Med. 2012 Mar; 87(3):372-7.Herzig SJ, Aird WC, Shah BJ, McKernan M, Zeidel ML. Acad Med2012 Mar87(3):372-7http://www.ncbi.nlm.nih.gov/pubmed/22617763Vascular heterogeneity in the kidney. Semin Nephrol. 2012 Mar; 32(2):145-55.Molema G, Aird WC. Semin Nephrol2012 Mar32(2):145-55http://www.ncbi.nlm.nih.gov/pubmed/22342727Embryonic stem cell differentiation system for evaluating gene functions involved in physiological megakaryocytic differentiation. Biochem Biophys Res Commun. 2012 Mar 16; 419(3):477-81.Okada Y, Yonekura M, Watanabe M, Nakai T, Wakimura A, Shimizu M, Kamikawa Y, Kitayama M, Kitajima K, Aird WC, Doi T. Biochem Biophys Res Commun2012 Mar 16419(3):477-81http://www.ncbi.nlm.nih.gov/pubmed/22235125ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. J Biol Chem. 2012 Feb 24; 287(9):6582-91.Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P. J Biol Chem2012 Feb 24287(9):6582-91http://www.ncbi.nlm.nih.gov/pubmed/22315715Endothelial cell heterogeneity. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a006429.Aird WC. Cold Spring Harb Perspect Med2012 Jan2(1):a006429http://www.ncbi.nlm.nih.gov/pubmed/21931859Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. PLoS One. 2011; 6(9):e24837.Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T. 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J Biol Chem2004 May 14279(20):20626-35http://www.ncbi.nlm.nih.gov/pubmed/15171965Natural anticoagulant inhibitors: activated Protein C. Best Pract Res Clin Haematol. 2004 Mar; 17(1):161-82.Aird WC. Best Pract Res Clin Haematol2004 Mar17(1):161-82http://www.ncbi.nlm.nih.gov/pubmed/14656735Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):294-300.Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, Walsh K, Aird WC. Arterioscler Thromb Vasc Biol2004 Feb24(2):294-300http://www.ncbi.nlm.nih.gov/pubmed/14724463Oxygen delivery. Crit Care Med. 2003 Dec; 31(12 Suppl):S658-67.Hameed SM, Aird WC, Cohn SM. Crit Care Med2003 Dec31(12 Suppl):S658-67http://www.ncbi.nlm.nih.gov/pubmed/14551154Thrombin and phenotypic modulation of the endothelium. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):41-53.Minami T, Sugiyama A, Wu SQ, Abid R, Kodama T, Aird WC. Arterioscler Thromb Vasc Biol2004 Jan24(1):41-53http://www.ncbi.nlm.nih.gov/pubmed/14551207The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem. 2004 Jan 09; 279(2):1513-25.Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K. J Biol Chem2004 Jan 09279(2):1513-25http://www.ncbi.nlm.nih.gov/pubmed/12893685Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol. 2003 Nov 01; 23(11):2041-7.Minami T, Kuivenhoven JA, Evans V, Kodama T, Rosenberg RD, Aird WC. Arterioscler Thromb Vasc Biol2003 Nov 0123(11):2041-7http://www.ncbi.nlm.nih.gov/pubmed/12839083The hematologic system as a marker of organ dysfunction in sepsis. Mayo Clin Proc. 2003 Jul; 78(7):869-81.Aird WC. Mayo Clin Proc2003 Jul78(7):869-81http://www.ncbi.nlm.nih.gov/pubmed/12682444Endothelial cell heterogeneity. Crit Care Med. 2003 Apr; 31(4 Suppl):S221-30.Aird WC. Crit Care Med2003 Apr31(4 Suppl):S221-30http://www.ncbi.nlm.nih.gov/pubmed/12871493Hemostasis and irreducible complexity. J Thromb Haemost. 2003 Feb; 1(2):227-30.Aird WC. J Thromb Haemost2003 Feb1(2):227-30http://www.ncbi.nlm.nih.gov/pubmed/12543866Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood. 2003 May 15; 101(10):3940-7.Pawlinski R, Pedersen B, Kehrle B, Aird WC, Frank RD, Guha M, Mackman N. Blood2003 May 15101(10):3940-7http://www.ncbi.nlm.nih.gov/pubmed/12543869The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003 May 15; 101(10):3765-77.Aird WC. Blood2003 May 15101(10):3765-77http://www.ncbi.nlm.nih.gov/pubmed/14633796Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2003; 497-519.Warkentin TE, Aird WC, Rand JH. Hematology Am Soc Hematol Educ Program2003497-519http://www.ncbi.nlm.nih.gov/pubmed/12493764Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem. 2003 Feb 28; 278(9):6976-84.Minami T, Abid MR, Zhang J, King G, Kodama T, Aird WC. J Biol Chem2003 Feb 28278(9):6976-84http://www.ncbi.nlm.nih.gov/pubmed/12393668Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood. 2002 Dec 01; 100(12):4019-25.Minami T, Donovan DJ, Tsai JC, Rosenberg RD, Aird WC. Blood2002 Dec 01100(12):4019-25http://www.ncbi.nlm.nih.gov/pubmed/12118099Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set". Physiol Genomics. 2002 Jul 12; 10(1):1-3.Aird WC, Glueck SB, Dzau VJ, Pratt RE. Physiol Genomics2002 Jul 1210(1):1-3http://www.ncbi.nlm.nih.gov/pubmed/12393577The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells. Blood. 2002 Dec 15; 100(13):4454-61.Wu SQ, Minami T, Donovan DJ, Aird WC. Blood2002 Dec 15100(13):4454-61http://www.ncbi.nlm.nih.gov/pubmed/12015397Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-2002. A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting. N Engl J Med. 2002 05 16; 346(20):1562-70.Aird WC, Mark EJ. N Engl J Med2002 05 16346(20):1562-70http://www.ncbi.nlm.nih.gov/pubmed/12004233Endothelial cell dynamics and complexity theory. Crit Care Med. 2002 May; 30(5 Suppl):S180-5.Aird WC. Crit Care Med2002 May30(5 Suppl):S180-5http://www.ncbi.nlm.nih.gov/pubmed/12011586Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter. J Vasc Res. 2002 Mar-Apr; 39(2):148-59.Tsai JC, Zhang J, Minami T, Voland C, Zhao S, Yi X, Lassalle P, Oettgen P, Aird WC. J Vasc Res2002 Mar-Apr39(2):148-59http://www.ncbi.nlm.nih.gov/pubmed/11709430PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2612-8.Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post MJ. Am J Physiol Heart Circ Physiol2001 Dec281(6):H2612-8http://www.ncbi.nlm.nih.gov/pubmed/11668036Epidermal growth factor induces Egr-1 promoter activity in hepatocytes in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol. 2001 Nov; 281(5):G1271-8.Tsai JC, Liu L, Zhang J, Spokes KC, Topper JN, Aird WC. Am J Physiol Gastrointest Liver Physiol2001 Nov281(5):G1271-8http://www.ncbi.nlm.nih.gov/pubmed/11600404NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1422-33.Stevens T, Rosenberg R, Aird W, Quertermous T, Johnson FL, Garcia JG, Hebbel RP, Tuder RM, Garfinkel S. Am J Physiol Cell Physiol2001 Nov281(5):C1422-33http://www.ncbi.nlm.nih.gov/pubmed/11590177Thrombin stimulation of the vascular cell adhesion molecule-1 promoter in endothelial cells is mediated by tandem nuclear factor-kappa B and GATA motifs. J Biol Chem. 2001 Dec 14; 276(50):47632-41.Minami T, Aird WC. J Biol Chem2001 Dec 14276(50):47632-41http://www.ncbi.nlm.nih.gov/pubmed/11641265Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism. FASEB J. 2001 Nov; 15(13):2548-50.Abid MR, Tsai JC, Spokes KC, Deshpande SS, Irani K, Aird WC. FASEB J2001 Nov15(13):2548-50http://www.ncbi.nlm.nih.gov/pubmed/11445731Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis. Crit Care Med. 2001 Jul; 29(7 Suppl):S28-34; discussion S34-5.Aird WC. Crit Care Med2001 Jul29(7 Suppl):S28-34; discussion S34-5http://www.ncbi.nlm.nih.gov/pubmed/11119713NADPH oxidase activity is required for endothelial cell proliferation and migration. FEBS Lett. 2000 Dec 15; 486(3):252-6.Abid MR, Kachra Z, Spokes KC, Aird WC. FEBS Lett2000 Dec 15486(3):252-6http://www.ncbi.nlm.nih.gov/pubmed/11098056Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site. J Biol Chem. 2001 Feb 16; 276(7):5395-402.Minami T, Rosenberg RD, Aird WC. J Biol Chem2001 Feb 16276(7):5395-402http://www.ncbi.nlm.nih.gov/pubmed/11029289The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells. Am J Physiol Cell Physiol. 2000 Nov; 279(5):C1414-24.Tsai JC, Liu L, Guan J, Aird WC. Am J Physiol Cell Physiol2000 Nov279(5):C1414-24http://www.ncbi.nlm.nih.gov/pubmed/11023970The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice. FASEB J. 2000 Oct; 14(13):1870-2.Tsai JC, Liu L, Cooley BC, DiChiara MR, Topper JN, Aird WC. FASEB J2000 Oct14(13):1870-2http://www.ncbi.nlm.nih.gov/pubmed/10961876Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood. 2000 Sep 01; 96(5):1772-81.Liu L, Tsai JC, Aird WC. Blood2000 Sep 0196(5):1772-81http://www.ncbi.nlm.nih.gov/pubmed/10813714Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen. Cancer. 2000 May 01; 88(9):2037-41.Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN. Cancer2000 May 0188(9):2037-41http://www.ncbi.nlm.nih.gov/pubmed/11015584Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000 Mar 13; 2(2):67-75.Evans V, Hatzopoulos A, Aird WC, Rayburn HB, Rosenberg RD, Kuivenhoven JA. Physiol Genomics2000 Mar 132(2):67-75http://www.ncbi.nlm.nih.gov/pubmed/11015585Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics. 2000 Mar 13; 2(2):77-83.Guillot PV, Liu L, Kuivenhoven JA, Guan J, Rosenberg RD, Aird WC. Physiol Genomics2000 Mar 132(2):77-83http://www.ncbi.nlm.nih.gov/pubmed/10613823PR39, a peptide regulator of angiogenesis. Nat Med. 2000 Jan; 6(1):49-55.Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Sellke F, Carmeliet P, Simons M. Nat Med2000 Jan6(1):49-55http://www.ncbi.nlm.nih.gov/pubmed/11129402The endothelium and thrombosis. Semin Thromb Hemost. 2000; 26(5):463-78.Gross PL, Aird WC. Semin Thromb Hemost200026(5):463-78http://www.ncbi.nlm.nih.gov/pubmed/10552950Characterization of the mouse von Willebrand factor promoter. Blood. 1999 Nov 15; 94(10):3405-12.Guan J, Guillot PV, Aird WC. Blood1999 Nov 1594(10):3405-12http://www.ncbi.nlm.nih.gov/pubmed/10332019Vascular-bed--specific hemostasis and hypercoagulable states. N Engl J Med. 1999 May 20; 340(20):1555-64.Rosenberg RD, Aird WC. N Engl J Med1999 May 20340(20):1555-64http://www.ncbi.nlm.nih.gov/pubmed/10079100A vascular bed-specific pathway. J Clin Invest. 1999 Mar; 103(6):799-805.Guillot PV, Guan J, Liu L, Kuivenhoven JA, Rosenberg RD, Sessa WC, Aird WC. J Clin Invest1999 Mar103(6):799-805http://www.ncbi.nlm.nih.gov/pubmed/9710453PDGF mediates cardiac microvascular communication. J Clin Invest. 1998 Aug 15; 102(4):837-43.Edelberg JM, Aird WC, Wu W, Rayburn H, Mamuya WS, Mercola M, Rosenberg RD. J Clin Invest1998 Aug 15102(4):837-43http://www.ncbi.nlm.nih.gov/pubmed/9435305Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest. 1998 Jan 15; 101(2):337-43.Edelberg JM, Aird WC, Rosenberg RD. J Clin Invest1998 Jan 15101(2):337-43http://www.ncbi.nlm.nih.gov/pubmed/9281588Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997 Sep 08; 138(5):1117-24.Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD. J Cell Biol1997 Sep 08138(5):1117-24http://www.ncbi.nlm.nih.gov/pubmed/8681807Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos. Development. 1996 Jul; 122(7):2271-81.Weiler-Guettler H, Aird WC, Rayburn H, Husain M, Rosenberg RD. Development1996 Jul122(7):2271-81http://www.ncbi.nlm.nih.gov/pubmed/8575060Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb; 78(2):180-7.Weiler-Guettler H, Aird WC, Husain M, Rayburn H, Rosenberg RD. Circ Res1996 Feb78(2):180-7http://www.ncbi.nlm.nih.gov/pubmed/7753844Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4567-71.Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD. Proc Natl Acad Sci U S A1995 May 0992(10):4567-71http://www.ncbi.nlm.nih.gov/pubmed/8288642The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression. J Biol Chem. 1994 Jan 14; 269(2):883-9.Aird WC, Parvin JD, Sharp PA, Rosenberg RD. J Biol Chem1994 Jan 14269(2):883-9http://www.ncbi.nlm.nih.gov/pubmed/1628134Long-term cryopreservation of human stem cells. Bone Marrow Transplant. 1992 Jun; 9(6):487-90.Aird W, Labopin M, Gorin NC, Antin JH. Bone Marrow Transplant1992 Jun9(6):487-90http://www.ncbi.nlm.nih.gov/pubmed/1905601Can oxygen consumption in blood in vitro be detected by a change in PCO2? Clin Invest Med. 1991 Apr; 14(2):125-30.Aird W, Cheema-Dhadli S, Sonnenberg B, Vandenbroucke A, Halperin M. Clin Invest Med1991 Apr14(2):125-30http://www.ncbi.nlm.nih.gov/pubmed/3400636Profound hypokalemia secondary to modest potassium depletion in a patient with coexisting hyponatremia: therapeutic implications. Am J Kidney Dis. 1988 Aug; 12(2):164-6.Aird W, Douek K, Halperin ML. Am J Kidney Dis1988 Aug12(2):164-6Endothelium, Vascular694.860009174304135e+0001995-05-09T00:00:002019-01-12T00:00:00Endothelial Cells513.132920237498747e+0002003-10-08T00:00:002019-11-11T00:00:00von Willebrand Factor172.273154227859023e+0001995-05-09T00:00:002019-01-12T00:00:00Promoter Regions, Genetic351.742704203290461e+0001994-01-14T00:00:002020-01-29T00:00:00Hemostasis121.463433580239473e+0001999-05-20T00:00:002022-07-01T00:00:00Thrombin121.392023901299613e+0002001-10-05T00:00:002009-11-23T00:00:00Sepsis231.336113634403199e+0002001-07-01T00:00:002019-08-01T00:00:00Gene Expression Regulation351.248802606538254e+0001994-01-14T00:00:002019-11-11T00:00:00Endothelium71.188019215515835e+0002001-10-05T00:00:002011-04-04T00:00:00Hagfishes41.160042752648927e+0002006-09-21T00:00:002017-09-12T00:00:00Vascular Endothelial Growth Factor A211.153510942958847e+0001998-08-15T00:00:002017-01-19T00:00:00Receptors, Cell Surface111.085527512097360e+0002007-05-10T00:00:002019-01-02T00:00:00Vascular Cell Adhesion Molecule-1141.079156487726110e+0002001-10-05T00:00:002020-01-29T00:00:00Vascular Endothelial Growth Factor Receptor-1109.448573204032926e-0012002-08-01T00:00:002017-01-19T00:00:00Blood Vessels79.424788467145755e-0012000-03-13T00:00:002015-01-01T00:00:00Blood Coagulation108.340070585408017e-0011999-05-20T00:00:002018-03-12T00:00:00Forkhead Transcription Factors108.204153168315164e-0012003-10-08T00:00:002015-07-01T00:00:00Hypoxanthine Phosphoribosyltransferase88.065717499372043e-0012000-03-13T00:00:002014-05-22T00:00:00Transcription Factors267.839175624642928e-0011994-01-14T00:00:002018-04-04T00:00:00Immediate-Early Proteins67.534038855793667e-0012000-09-01T00:00:002003-01-23T00:00:00Capillaries67.449171510425807e-0012000-01-01T00:00:002016-01-08T00:00:00Biological Evolution56.988648672596438e-0012003-02-01T00:00:002013-06-01T00:00:00Thrombosis126.756806281723344e-0011999-05-20T00:00:002022-07-01T00:00:00NADPH Oxidases76.690762735582562e-0012000-12-15T00:00:002010-06-02T00:00:00Umbilical Veins156.552956673300582e-0012000-01-01T00:00:002009-11-23T00:00:00Multiple Organ Failure46.436002256556450e-0012002-05-01T00:00:002010-10-13T00:00:00RNA, Messenger286.237434203501151e-0011994-01-14T00:00:002019-11-11T00:00:00DNA-Binding Proteins216.180706967514612e-0011994-01-14T00:00:002018-04-04T00:00:00Lipopolysaccharides135.941003784260119e-0012003-01-23T00:00:002019-11-11T00:00:00Proto-Oncogene Proteins c-akt85.900523667807396e-0012003-10-08T00:00:002014-05-29T00:00:00Cells, Cultured405.868888894623444e-0011996-07-01T00:00:002019-01-12T00:00:00Neovascularization, Pathologic105.513666190033559e-0012002-07-12T00:00:002019-01-02T00:00:00Signal Transduction315.442523295575258e-0011999-03-01T00:00:002019-01-02T00:00:00Animals1034.901150419447721e-0011994-01-14T00:00:002024-07-10T00:00:00Neovascularization, Physiologic64.849762567713368e-0011998-08-15T00:00:002014-07-09T00:00:00Human Umbilical Vein Endothelial Cells94.744084614068914e-0012012-01-10T00:00:002020-01-29T00:00:00Megakaryocytes64.738109853825991e-0011995-05-09T00:00:002024-07-10T00:00:00Thrombomodulin64.600704716320421e-0011996-02-01T00:00:002017-01-19T00:00:00Gene Expression104.421380915018833e-0011996-02-01T00:00:002017-09-12T00:00:00NF-kappa B74.284014636816168e-0012001-10-05T00:00:002017-01-01T00:00:00Epidermal Growth Factor34.179664142431339e-0012000-09-01T00:00:002001-11-01T00:00:00Transcription Factor AP-114.158958458505992e-0012015-10-14T00:00:002015-10-14T00:00:00Mice, Transgenic274.154656563932506e-0011995-05-09T00:00:002019-01-12T00:00:00Phenotype194.138802940170907e-0012001-07-01T00:00:002016-03-16T00:00:00Blood Coagulation Factors24.087404344246163e-0012001-07-01T00:00:002015-01-01T00:00:00Protein Modification, Translational13.957406718628014e-0012013-01-28T00:00:002013-01-28T00:00:00Nuclear Proteins73.934997488299021e-0011994-01-14T00:00:002010-04-04T00:00:00Lac Operon73.920561506690221e-0011999-03-01T00:00:002013-03-25T00:00:00Blood Coagulation Disorders33.875901345526368e-0011999-05-20T00:00:002020-09-26T00:00:00Malaria, Cerebral13.836644345427399e-0012013-11-18T00:00:002013-11-18T00:00:00Shock, Septic33.831871205312739e-0012011-03-21T00:00:002018-11-20T00:00:00Aorta63.791682170442103e-0011995-05-09T00:00:002016-01-08T00:00:00Receptor, TIE-253.791093047291592e-0012000-03-13T00:00:002013-04-06T00:00:00Vascular Diseases33.782619831251934e-0012008-01-01T00:00:002010-05-20T00:00:00GA-Binding Protein Transcription Factor33.724313140741300e-0012007-05-10T00:00:002011-09-12T00:00:00Mice653.703389698750458e-0011994-01-14T00:00:002024-07-10T00:00:00Roundabout Proteins73.679513496731773e-0012007-05-10T00:00:002018-04-04T00:00:00Inflammation153.662040815090408e-0012003-01-23T00:00:002019-08-01T00:00:00Mosaicism13.645511480100314e-0012016-01-08T00:00:002016-01-08T00:00:00Cardiovascular System23.637272210404122e-0012007-02-02T00:00:002011-07-01T00:00:00Endotoxemia63.608239238033913e-0012003-01-23T00:00:002019-01-02T00:00:00Blood Circulation23.602586436286478e-0011999-03-01T00:00:002011-07-01T00:00:00Tumor Necrosis Factor-alpha143.480800882873424e-0012001-10-05T00:00:002020-01-29T00:00:00Dermis33.461283553414760e-0012006-09-21T00:00:002013-02-28T00:00:00Proteoglycans23.435214429250177e-0012002-03-01T00:00:002006-09-07T00:00:00Nitric Oxide Synthase43.330144853055113e-0011999-03-01T00:00:002005-09-19T00:00:00Organ Specificity93.329284237675900e-0011995-05-09T00:00:002019-11-11T00:00:00Endothelial Growth Factors43.301369846801674e-0011998-08-15T00:00:002001-09-17T00:00:00Thromboplastin43.296586611732508e-0012003-01-23T00:00:002018-06-06T00:00:00Muscle, Smooth, Vascular43.267327141239844e-0012000-03-13T00:00:002013-02-28T00:00:00Superoxide Dismutase23.264523120758549e-0012001-09-17T00:00:002004-08-11T00:00:00Pregnancy Proteins23.249053465386141e-0012006-05-15T00:00:002008-10-13T00:00:00Protein C33.214085390395323e-0012004-03-01T00:00:002007-10-01T00:00:00Lymphokines43.198760955198001e-0011998-08-15T00:00:002001-09-17T00:00:00Forkhead Box Protein O173.187689870252410e-0012003-10-08T00:00:002015-07-01T00:00:00Early Growth Response Protein 183.182290795863857e-0012000-09-01T00:00:002009-11-23T00:00:00I-kappa B Proteins43.166964173919378e-0012001-12-01T00:00:002006-04-20T00:00:00Nonlinear Dynamics13.141510319688661e-0012012-06-22T00:00:002012-06-22T00:00:00Cloning, Molecular53.138960823095245e-0011999-11-15T00:00:002018-03-12T00:00:00Cell Adhesion123.126194412946646e-0012005-05-09T00:00:002018-09-30T00:00:00Muscle Proteins53.090768449465238e-0012004-09-23T00:00:002013-02-27T00:00:00Early Growth Response Transcription Factors13.082834625043827e-0012009-10-12T00:00:002009-10-12T00:00:00Active Transport, Cell Nucleus83.046858343220275e-0012003-10-08T00:00:002008-09-11T00:00:00GATA Transcription Factors13.045608432528096e-0012009-05-30T00:00:002009-05-30T00:00:00CREB-Binding Protein12.976104159653797e-0012009-10-12T00:00:002009-10-12T00:00:00Erythropoiesis12.940713158382950e-0012013-01-28T00:00:002013-01-28T00:00:00Spleen32.929033261390286e-0011995-05-09T00:00:002013-01-28T00:00:00Humans1402.864750789900766e-0011988-08-01T00:00:002024-07-10T00:00:00Platelet Factor 432.848673965368218e-0011994-01-14T00:00:002013-09-01T00:00:00Kidney92.828461811967308e-0011995-05-09T00:00:002019-01-12T00:00:00Proto-Oncogene Proteins62.780610142980725e-0011998-08-15T00:00:002018-04-04T00:00:00Thrombopoiesis22.771423369031875e-0012013-02-27T00:00:002024-07-10T00:00:00RNA Splicing12.765606380913946e-0012013-03-25T00:00:002013-03-25T00:00:00Multiprotein Complexes12.761803725976054e-0012014-05-29T00:00:002014-05-29T00:00:00Leukocytes52.736712503446831e-0012005-05-09T00:00:002019-08-01T00:00:00Forkhead Box Protein O342.725947541248618e-0012003-12-01T00:00:002014-05-29T00:00:00DNA Methylation52.698398664125891e-0012013-02-28T00:00:002019-01-12T00:00:00Hyperhomocysteinemia12.666243329517447e-0012008-03-24T00:00:002008-03-24T00:00:00Intercellular Adhesion Molecule-1102.664606840419040e-0012001-12-01T00:00:002013-05-01T00:00:00Factor VIIa22.658806323008999e-0012018-03-12T00:00:002018-06-06T00:00:00Muscle, Skeletal52.646745004100113e-0011997-09-08T00:00:002014-07-09T00:00:00Proto-Oncogene Proteins c-ets42.639145981985397e-0012002-03-01T00:00:002013-09-01T00:00:00Neoplasms, Experimental32.588307121960790e-0012002-08-01T00:00:002008-06-02T00:00:00Hepatocyte Growth Factor12.567636664533611e-0012008-09-11T00:00:002008-09-11T00:00:00Physiology12.556412191371620e-0012007-08-10T00:00:002007-08-10T00:00:00Homeostasis52.547031012802563e-0012010-05-20T00:00:002024-07-10T00:00:00Mesenteric Arteries12.518446843432776e-0012007-05-30T00:00:002007-05-30T00:00:00Models, Cardiovascular22.507574773990142e-0012007-08-10T00:00:002015-01-01T00:00:00Cell Lineage32.488709394040287e-0012013-03-25T00:00:002024-07-10T00:00:00Thrombocytopenia42.481343761507748e-0012000-05-01T00:00:002005-07-01T00:00:00Transcriptional Activation82.439640627201096e-0012000-11-29T00:00:002012-01-10T00:00:00Chromatin Immunoprecipitation62.384199793774121e-0012010-04-29T00:00:002016-01-08T00:00:00Erythropoietin32.380959955991925e-0011994-01-14T00:00:002013-01-28T00:00:00Cardiovascular Physiological Phenomena12.364690130967837e-0012007-08-10T00:00:002007-08-10T00:00:00Myocytes, Smooth Muscle32.314672094294502e-0012005-04-15T00:00:002014-05-22T00:00:00Malaria, Falciparum12.290708911866097e-0012013-11-18T00:00:002013-11-18T00:00:00TOR Serine-Threonine Kinases12.267638952365245e-0012014-05-29T00:00:002014-05-29T00:00:00Antigens, CD32.260569661936599e-0012013-02-28T00:00:002019-01-02T00:00:00Base Sequence92.259519615778247e-0011994-01-14T00:00:002015-10-14T00:00:00Transfection102.246520059201850e-0011996-07-01T00:00:002014-05-22T00:00:00RNA, Small Interfering92.237123361144535e-0012006-09-15T00:00:002019-01-12T00:00:00Homocysteine12.224497764084688e-0012008-03-24T00:00:002008-03-24T00:00:00Models, Biological82.210650233609287e-0011998-08-15T00:00:002012-06-22T00:00:00Oxidation-Reduction32.203419595018960e-0012004-08-11T00:00:002010-06-02T00:00:00Hematologic Diseases32.183118485105771e-0012001-11-01T00:00:002003-07-01T00:00:00Erythrocytes12.157271189251364e-0012013-11-18T00:00:002013-11-18T00:00:00Sequence Homology, Nucleic Acid32.151449862804751e-0011999-11-15T00:00:002015-10-14T00:00:00Phosphatidylinositol 3-Kinases52.141927592438556e-0012002-12-18T00:00:002008-09-11T00:00:00Trans-Activators62.140180128998884e-0012003-07-31T00:00:002012-01-10T00:00:00Platelet-Derived Growth Factor52.121607780255901e-0011998-08-15T00:00:002005-09-19T00:00:00Environment12.106107550223891e-0012010-05-20T00:00:002010-05-20T00:00:00Myocardium82.089410798760605e-0011995-05-09T00:00:002019-01-12T00:00:00Heart62.073500150901571e-0011997-09-08T00:00:002010-10-27T00:00:00Intracellular Signaling Peptides and Proteins72.071279700801002e-0012003-10-08T00:00:002013-02-27T00:00:00Plasmodium falciparum12.063920346566871e-0012013-11-18T00:00:002013-11-18T00:00:00Monocytes72.028998547244704e-0012006-04-20T00:00:002017-11-11T00:00:00Receptors, Growth Factor32.026833497847891e-0011998-08-15T00:00:002000-11-29T00:00:00Serum Response Factor22.018951886703913e-0012002-06-28T00:00:002009-11-23T00:00:00Phosphorylation92.018894249530646e-0012000-09-01T00:00:002008-09-11T00:00:00Mice, Inbred C57BL231.982323624287480e-0012000-01-01T00:00:002024-07-10T00:00:00Tunica Intima11.966876008719242e-0012005-06-15T00:00:002005-06-15T00:00:00Gene Targeting31.964278855505889e-0012000-03-13T00:00:002002-07-12T00:00:00Vasodilation11.956389148256366e-0012007-05-30T00:00:002007-05-30T00:00:00Serum Response Element11.905278854271202e-0012002-06-28T00:00:002002-06-28T00:00:00Enzyme Induction31.899565664314156e-0011999-03-01T00:00:002014-05-29T00:00:00Gene Expression Profiling51.885354422838947e-0012002-07-12T00:00:002019-01-12T00:00:00Protein Binding81.868364470669159e-0012001-10-05T00:00:002018-06-06T00:00:00Nitric Oxide Synthase Type III51.860673774839121e-0011999-03-01T00:00:002014-05-29T00:00:00Microcirculation41.837746810800019e-0011997-09-08T00:00:002018-11-20T00:00:00Pneumonia21.812381211382590e-0012008-11-14T00:00:002011-03-21T00:00:00Genes, Reporter81.808540738981753e-0011997-09-08T00:00:002010-04-29T00:00:00Intravital Microscopy21.803370468037120e-0012018-09-30T00:00:002024-07-10T00:00:00Atherosclerosis31.795924023636988e-0012006-01-01T00:00:002008-03-24T00:00:00Gene Expression Regulation, Developmental51.747103437343625e-0011996-07-01T00:00:002014-05-22T00:00:00Cattle61.746361819290982e-0012000-01-01T00:00:002013-03-25T00:00:00Reactive Oxygen Species61.742681848432097e-0012000-12-15T00:00:002010-06-02T00:00:00Receptor Cross-Talk21.731910344968629e-0012001-07-01T00:00:002017-11-11T00:00:00GATA2 Transcription Factor51.729744758215137e-0011994-01-14T00:00:002009-07-13T00:00:00Lampreys21.719646065675536e-0012018-03-12T00:00:002018-06-06T00:00:00beta-Galactosidase71.715100416449026e-0011995-05-09T00:00:002004-03-16T00:00:00Cell Line141.698782528428932e-0012000-03-13T00:00:002017-11-11T00:00:00Database Management Systems11.695723917898050e-0012002-07-12T00:00:002002-07-12T00:00:00NFATC Transcription Factors41.694557585372802e-0012006-04-20T00:00:002013-02-27T00:00:00E-Selectin51.665305220426555e-0012005-09-19T00:00:002013-05-01T00:00:00Plasminogen Activator Inhibitor 141.640810650384305e-0012003-01-23T00:00:002013-05-01T00:00:00Transcriptional Regulator ERG51.633766836067211e-0012009-04-09T00:00:002012-08-29T00:00:00Receptors, Vascular Endothelial Growth Factor41.631040057718596e-0011998-08-15T00:00:002015-12-30T00:00:00Protein Transport31.599952743758102e-0012002-06-28T00:00:002017-09-12T00:00:00Early Growth Response Protein 321.595456969754325e-0012009-10-12T00:00:002009-11-23T00:00:00rac1 GTP-Binding Protein11.594540450697083e-0012001-09-17T00:00:002001-09-17T00:00:00Down-Regulation81.587451426389455e-0012000-11-29T00:00:002013-04-06T00:00:00Amino Acid Motifs41.584331899164173e-0012001-10-05T00:00:002003-07-31T00:00:00Structure-Activity Relationship31.573087166457629e-0012007-02-02T00:00:002018-03-12T00:00:00Computational Biology11.561818953842535e-0012012-06-22T00:00:002012-06-22T00:00:00Microvessels31.558173438802885e-0012012-01-10T00:00:002013-11-18T00:00:00Systemic Inflammatory Response Syndrome11.554099708705866e-0012005-07-01T00:00:002005-07-01T00:00:00Binding Sites71.554041806949248e-0012002-03-01T00:00:002014-05-22T00:00:00Epigenesis, Genetic41.551388148667766e-0012006-02-03T00:00:002020-01-29T00:00:00Coronary Vessels101.549052544637588e-0011998-08-15T00:00:002012-01-10T00:00:00Ribonucleases41.547587715876658e-0012001-10-05T00:00:002005-09-19T00:00:00Protein Kinase C21.535981767776699e-0012002-12-18T00:00:002008-01-28T00:00:00History, 17th Century21.530724679630428e-0012007-08-10T00:00:002011-07-01T00:00:00Receptor Protein-Tyrosine Kinases41.529911812715394e-0011998-08-15T00:00:002000-11-29T00:00:00Respiratory Mucosa11.515782683098240e-0012003-04-01T00:00:002003-04-01T00:00:00Evolution, Molecular21.513675201832152e-0012017-09-12T00:00:002018-03-12T00:00:00Lung81.503344792991370e-0011995-05-09T00:00:002019-01-12T00:00:00Cell Communication51.496997995409430e-0011998-08-15T00:00:002017-11-11T00:00:00Tumor Necrosis Factor Receptor-Associated Peptides and Proteins11.484512851326026e-0012019-01-02T00:00:002019-01-02T00:00:00Transcription Factor RelA41.481149294768719e-0012002-12-18T00:00:002020-01-29T00:00:00Introns21.479935214341220e-0012010-10-27T00:00:002013-03-25T00:00:00Blotting, Northern41.477459528808285e-0012001-09-17T00:00:002006-09-07T00:00:00Mice, Knockout101.470492623698834e-0011996-07-01T00:00:002019-01-02T00:00:00Oncogene Proteins31.469844976814215e-0012009-04-09T00:00:002012-08-29T00:00:00Real-Time Polymerase Chain Reaction41.459620820373090e-0012011-09-12T00:00:002019-08-01T00:00:00Molecular Biology11.432862684206141e-0012002-05-01T00:00:002002-05-01T00:00:00Solubility31.419441666648088e-0012008-04-01T00:00:002009-04-04T00:00:00Exons41.411100694074819e-0011995-05-09T00:00:002013-03-25T00:00:00Demethylation11.407773644278794e-0012018-04-04T00:00:002018-04-04T00:00:00Vascular Endothelial Growth Factors51.396241323684933e-0011998-08-15T00:00:002010-06-02T00:00:00Reverse Transcriptase Polymerase Chain Reaction41.383374840262724e-0012005-09-19T00:00:002011-05-31T00:00:00Pulmonary Artery51.377054493930892e-0012002-03-01T00:00:002016-01-08T00:00:00Extracellular Matrix Proteins11.365197706173254e-0012002-08-01T00:00:002002-08-01T00:00:00Weibel-Palade Bodies11.363266284798993e-0012017-09-12T00:00:002017-09-12T00:00:00Platelet Aggregation21.362428909607152e-0012017-09-12T00:00:002019-01-12T00:00:00Fish Proteins11.357592005720772e-0012018-03-12T00:00:002018-03-12T00:00:00Receptors, Immunologic21.351994095845544e-0012013-01-30T00:00:002017-01-01T00:00:00Angiopoietin-221.345357156434019e-0012015-07-01T00:00:002017-01-19T00:00:00Thrombelastography11.339803501217375e-0012020-09-26T00:00:002020-09-26T00:00:00Transplantation, Homologous11.338491213368910e-0012006-07-15T00:00:002006-07-15T00:00:00Embryo, Mammalian51.320552943198236e-0011996-07-01T00:00:002008-06-02T00:00:00Culture Media, Conditioned31.316693922701730e-0011999-03-01T00:00:002006-09-07T00:00:00Chromones41.308747713321087e-0012002-12-18T00:00:002008-01-28T00:00:00Tissue Distribution41.304711144014666e-0011999-03-01T00:00:002013-01-30T00:00:00Fluorescent Antibody Technique31.297188179788563e-0012000-03-13T00:00:002016-01-08T00:00:00Medicine11.292999389135202e-0012005-05-01T00:00:002005-05-01T00:00:00Cecum21.290229538410581e-0012006-05-15T00:00:002009-04-04T00:00:00Cell Membrane Permeability11.287807387276909e-0012019-01-02T00:00:002019-01-02T00:00:00Transcription, Genetic101.277832624267620e-0011994-01-14T00:00:002011-04-04T00:00:00Mixed Function Oxygenases11.274519202681826e-0012018-04-04T00:00:002018-04-04T00:00:00ADAMTS13 Protein11.268651277642736e-0012017-09-12T00:00:002017-09-12T00:00:00Molecular Sequence Data61.263644504788895e-0011994-01-14T00:00:002009-10-12T00:00:00Time Factors121.251292232305578e-0011992-06-01T00:00:002014-07-09T00:00:00Sp1 Transcription Factor31.231583718799267e-0012007-05-10T00:00:002019-01-12T00:00:00Platelet Endothelial Cell Adhesion Molecule-121.231352907987905e-0012006-09-07T00:00:002007-05-10T00:00:00Cardiology11.231179057372737e-0012007-08-10T00:00:002007-08-10T00:00:00Luciferases31.229358313253266e-0012001-10-05T00:00:002002-12-18T00:00:00Placenta Growth Factor21.209978702705311e-0012006-05-15T00:00:002008-10-13T00:00:00Hepatocytes21.208859855117374e-0012001-11-01T00:00:002013-02-28T00:00:00Vertebrates11.206698867795898e-0012017-09-12T00:00:002017-09-12T00:00:00Protein Conformation31.191323339613655e-0012017-09-12T00:00:002018-06-06T00:00:00DEAD Box Protein 5811.190859289750643e-0012016-04-29T00:00:002016-04-29T00:00:00Heparin21.177738669856697e-0012002-05-16T00:00:002003-01-01T00:00:00Cyclin-Dependent Kinase Inhibitor p2731.177322319422079e-0012003-12-01T00:00:002008-08-01T00:00:00Venous Thrombosis11.168101679885883e-0012005-07-01T00:00:002005-07-01T00:00:00Cricetulus11.166651065179731e-0012017-09-12T00:00:002017-09-12T00:00:00Nerve Tissue Proteins31.158096903625611e-0012005-06-15T00:00:002017-01-01T00:00:00Resuscitation21.155125409080494e-0012017-01-19T00:00:002018-11-20T00:00:00Adenoviridae41.149898785704263e-0012001-09-17T00:00:002014-07-09T00:00:00Databases, Genetic11.148116458844867e-0012002-07-12T00:00:002002-07-12T00:00:00Gene Regulatory Networks21.147634018290393e-0012012-06-22T00:00:002016-03-16T00:00:00Transgenes41.140331839989948e-0012000-03-13T00:00:002019-11-11T00:00:00Yolk Sac21.131155573203187e-0011996-07-01T00:00:002014-05-29T00:00:00Peptide Fragments21.129874603312383e-0012001-12-01T00:00:002007-05-10T00:00:00Cell Cycle31.116775111133519e-0012003-12-01T00:00:002016-03-16T00:00:00Anticoagulants41.110852087761562e-0012002-05-16T00:00:002020-08-23T00:00:00CHO Cells11.102908967619224e-0012017-09-12T00:00:002017-09-12T00:00:00Biomarkers81.094010272860894e-0011996-07-01T00:00:002017-01-19T00:00:00Bone Marrow31.087192383881128e-0012015-12-30T00:00:002024-07-10T00:00:00Capillary Permeability31.085836082523081e-0012012-01-10T00:00:002013-05-30T00:00:00Blotting, Western51.078283193820662e-0012001-09-17T00:00:002011-05-31T00:00:00Calcineurin21.074965658731380e-0012009-05-20T00:00:002013-02-27T00:00:00Neoplasms41.071526837942585e-0012008-08-23T00:00:002020-08-23T00:00:00Neoplasm Proteins21.067699488043423e-0012002-03-01T00:00:002006-09-07T00:00:00NIH 3T3 Cells11.065745600522997e-0012016-01-08T00:00:002016-01-08T00:00:00Blood Platelets51.062939298058489e-0012003-01-01T00:00:002024-07-10T00:00:00DNA, Complementary11.061232541609708e-0012017-09-12T00:00:002017-09-12T00:00:00Endothelial Protein C Receptor11.050975102768771e-0012013-11-18T00:00:002013-11-18T00:00:00Periodicals as Topic11.050363401257005e-0012005-05-01T00:00:002005-05-01T00:00:00Morpholines41.046930839769632e-0012002-12-18T00:00:002008-01-28T00:00:00Microscopy, Electron, Transmission11.041763532478306e-0012016-01-08T00:00:002016-01-08T00:00:00In Situ Hybridization21.035619748795683e-0012006-09-07T00:00:002008-10-13T00:00:00Interleukin-621.021355015843341e-0012008-04-01T00:00:002017-11-11T00:00:00Proto-Oncogene Proteins c-sis31.009027006409059e-0011998-08-15T00:00:002005-06-15T00:00:00Hospital Mortality69.984363205415130e-0022010-06-12T00:00:002017-01-19T00:00:00Megakaryocyte Progenitor Cells19.895599621734370e-0022013-02-27T00:00:002013-02-27T00:00:00Protein Domains19.849649521005396e-0022017-09-12T00:00:002017-09-12T00:00:00DNA Replication Timing19.846120344735330e-0022013-02-28T00:00:002013-02-28T00:00:00Mammary Neoplasms, Experimental19.800515158314932e-0022015-12-30T00:00:002015-12-30T00:00:00Immunohistochemistry59.777146551799544e-0021996-07-01T00:00:002016-01-08T00:00:00Transforming Growth Factor beta19.702853070510895e-0022000-11-29T00:00:002000-11-29T00:00:00Blood Platelet Disorders19.677863241378279e-0022013-09-01T00:00:002013-09-01T00:00:00Simvastatin19.597725758191000e-0022015-07-01T00:00:002015-07-01T00:00:00Dendritic Cells19.503898335248188e-0022024-07-10T00:00:002024-07-10T00:00:00Becaplermin29.476479149377245e-0022000-11-01T00:00:002005-06-15T00:00:00Protein Folding19.433045902723401e-0022017-09-12T00:00:002017-09-12T00:00:00Severity of Illness Index19.417057350934011e-0022010-10-13T00:00:002010-10-13T00:00:00Respiratory Distress Syndrome19.412454691149469e-0022003-04-01T00:00:002003-04-01T00:00:00Bone Morphogenetic Protein 419.377520604568439e-0022013-01-28T00:00:002013-01-28T00:00:00Protein Multimerization19.362220999139871e-0022017-09-12T00:00:002017-09-12T00:00:00Physiology, Comparative19.360175780698546e-0022012-03-01T00:00:002012-03-01T00:00:00Oligonucleotide Array Sequence Analysis59.305343908130173e-0022003-10-09T00:00:002011-04-04T00:00:00Mitogen-Activated Protein Kinases39.295543610138626e-0022000-09-01T00:00:002002-12-18T00:00:00Amino Acid Sequence39.292827812142983e-0022017-09-12T00:00:002019-01-02T00:00:00Osteopontin19.270379074773869e-0022014-07-09T00:00:002014-07-09T00:00:00Toll-Like Receptor 419.264474303034077e-0022016-04-29T00:00:002016-04-29T00:00:00Biomedical Research29.235908399172339e-0022004-05-01T00:00:002005-05-01T00:00:00Receptors, Lysosphingolipid19.201583104521467e-0022013-05-30T00:00:002013-05-30T00:00:00Enzyme Inhibitors69.198796314580271e-0022000-12-15T00:00:002014-05-22T00:00:00Electrophoretic Mobility Shift Assay39.063225774149625e-0022002-06-28T00:00:002013-09-01T00:00:00Protein Biosynthesis19.033107362886711e-0022019-11-11T00:00:002019-11-11T00:00:00Renal Veins18.988478263942067e-0022012-03-01T00:00:002012-03-01T00:00:00Acetophenones28.879103737255398e-0022000-12-15T00:00:002002-12-18T00:00:00Down Syndrome48.863062833333869e-0022004-09-23T00:00:002013-02-27T00:00:00Biomarkers, Tumor38.848538830130505e-0022008-05-21T00:00:002013-01-30T00:00:00S Phase18.844607647388815e-0022013-02-28T00:00:002013-02-28T00:00:00Cadherins38.813914388235558e-0022007-05-10T00:00:002019-01-02T00:00:00History, 16th Century18.744314222371599e-0022011-07-01T00:00:002011-07-01T00:00:00Endocardium18.732522987144245e-0022012-08-29T00:00:002012-08-29T00:00:00Cell Division48.725176703333951e-0022000-12-15T00:00:002016-03-16T00:00:00Gene Knock-In Techniques18.717614597044669e-0022013-03-25T00:00:002013-03-25T00:00:00Core Binding Factor Alpha 2 Subunit18.715966007987465e-0022013-09-01T00:00:002013-09-01T00:00:00Macrophage Activation18.711043271448854e-0022014-07-09T00:00:002014-07-09T00:00:00Hemorrhage28.702554830595737e-0022020-08-23T00:00:002020-09-10T00:00:00DNA Footprinting28.694413525946784e-0022000-11-29T00:00:002002-03-01T00:00:00Shock, Hemorrhagic18.592292272173602e-0022013-04-06T00:00:002013-04-06T00:00:00Arterioles18.566916481355154e-0022012-03-01T00:00:002012-03-01T00:00:00Proteolysis18.531951726189846e-0022017-09-12T00:00:002017-09-12T00:00:00Culture Media28.514664224331245e-0022000-11-01T00:00:002005-09-19T00:00:00Male358.457887728202772e-0021995-05-09T00:00:002024-07-10T00:00:00History, Ancient18.373976963519966e-0022011-07-01T00:00:002011-07-01T00:00:00Disease Models, Animal98.360490706740738e-0021999-05-20T00:00:002019-01-02T00:00:00Heart Valves18.339772820147343e-0022012-08-29T00:00:002012-08-29T00:00:00STAT6 Transcription Factor18.327183951244339e-0022011-04-04T00:00:002011-04-04T00:00:00Models, Genetic28.301254063395487e-0022001-10-05T00:00:002016-03-16T00:00:00Rats88.253560633299709e-0021994-01-14T00:00:002011-09-12T00:00:00Heart Failure28.250505891808985e-0022011-06-16T00:00:002014-05-29T00:00:00Dimerization28.241814607059485e-0022001-10-05T00:00:002002-12-18T00:00:00Dose-Response Relationship, Drug48.230650237654816e-0022000-12-15T00:00:002005-09-19T00:00:00Vascular Endothelial Growth Factor Receptor-238.219413878378189e-0022004-03-10T00:00:002013-02-28T00:00:00Cryopreservation28.158100527606543e-0021992-06-01T00:00:002014-05-01T00:00:00Claudins18.146979027225634e-0022012-01-10T00:00:002012-01-10T00:00:00Mutation78.141465340399452e-0022001-10-05T00:00:002013-09-01T00:00:00DNA Primers38.047147418647695e-0021997-09-08T00:00:002008-05-21T00:00:00Renal Artery18.028753326219539e-0022012-03-01T00:00:002012-03-01T00:00:00NFI Transcription Factors17.923196772152226e-0022010-04-29T00:00:002010-04-29T00:00:00Protein Processing, Post-Translational17.817845914298892e-0022017-09-12T00:00:002017-09-12T00:00:00Systems Biology17.804126936882086e-0022013-10-04T00:00:002013-10-04T00:00:00Serpins27.772593562669772e-0022003-10-08T00:00:002009-04-04T00:00:00In Situ Hybridization, Fluorescence17.727394482787359e-0022016-01-08T00:00:002016-01-08T00:00:00Mechanistic Target of Rapamycin Complex 117.704973518718040e-0022014-05-29T00:00:002014-05-29T00:00:00Embryonic Development27.679508159427662e-0021996-07-01T00:00:002010-05-20T00:00:00rho GTP-Binding Proteins17.603683010609215e-0022011-05-31T00:00:002011-05-31T00:00:00Physicians17.570261075916664e-0022007-08-10T00:00:002007-08-10T00:00:00Serpin E217.537956027111210e-0022009-04-04T00:00:002009-04-04T00:00:00Mesoderm17.492539758063228e-0022012-08-29T00:00:002012-08-29T00:00:00Kidney Glomerulus17.480816680226848e-0022012-03-01T00:00:002012-03-01T00:00:00Research Design17.474836455871360e-0022005-05-01T00:00:002005-05-01T00:00:00Blood Coagulation Tests17.431999003540052e-0022010-06-12T00:00:002010-06-12T00:00:00Muscle Contraction17.406678885805650e-0022014-05-01T00:00:002014-05-01T00:00:00Wounds, Stab17.393387218938148e-0022009-04-04T00:00:002009-04-04T00:00:00Arteries27.361737842289451e-0022002-05-16T00:00:002005-05-09T00:00:00Flow Cytometry37.359098405676925e-0022003-10-08T00:00:002016-01-08T00:00:00Regulatory Sequences, Nucleic Acid27.345143741381272e-0022000-03-13T00:00:002011-04-04T00:00:00Species Specificity17.309724011708821e-0022013-03-25T00:00:002013-03-25T00:00:00Embryonic Stem Cells27.266292234915758e-0022012-02-10T00:00:002014-05-22T00:00:00Cell Nucleus47.233571487716747e-0021994-01-14T00:00:002008-01-28T00:00:00Antimicrobial Cationic Peptides27.219060777732407e-0022000-01-01T00:00:002001-12-01T00:00:00Blood17.159766272599505e-0021991-04-01T00:00:001991-04-01T00:00:00GATA3 Transcription Factor17.087189235038743e-0022009-08-12T00:00:002009-08-12T00:00:00Inositol17.033040418466462e-0022009-05-20T00:00:002009-05-20T00:00:00Genes17.019567888966143e-0022012-02-10T00:00:002012-02-10T00:00:00Bone Marrow Cells26.996930085690263e-0022010-04-04T00:00:002013-01-28T00:00:00Protein Serine-Threonine Kinases46.986061193915599e-0022002-06-28T00:00:002009-05-20T00:00:00Ligation16.973178739126658e-0022009-04-04T00:00:002009-04-04T00:00:00Neutrophils46.941708423872139e-0022001-12-01T00:00:002009-04-09T00:00:00Up-Regulation36.920761928923344e-0022001-10-05T00:00:002008-09-11T00:00:00Female286.863715480024028e-0021988-08-01T00:00:002024-07-10T00:00:00Nitric Oxide Synthase Type II26.834641291003056e-0021999-03-01T00:00:002000-03-13T00:00:00Heart Transplantation36.833830471820573e-0021997-09-08T00:00:002004-03-16T00:00:00Apoptosis66.820872325448334e-0022001-07-01T00:00:002024-07-10T00:00:00Lung Transplantation16.779469991639994e-0021997-09-08T00:00:001997-09-08T00:00:00Macrophages36.758453274960387e-0022000-01-01T00:00:002014-07-09T00:00:00Emergency Service, Hospital46.752396033246658e-0022008-04-01T00:00:002020-09-26T00:00:00Gene Transfer Techniques36.723346034802544e-0021996-02-01T00:00:002003-12-01T00:00:00Recombinant Fusion Proteins26.720016529636071e-0022008-11-14T00:00:002014-05-29T00:00:00APACHE16.665000807597288e-0022008-04-01T00:00:002008-04-01T00:00:00Models, Molecular16.608966505507835e-0022017-09-12T00:00:002017-09-12T00:00:00Protein Isoforms26.593137775924461e-0022004-09-23T00:00:002019-11-11T00:00:00Interleukin-416.542132849065420e-0022011-04-04T00:00:002011-04-04T00:00:00Patient Discharge16.537683710466498e-0022020-09-10T00:00:002020-09-10T00:00:00Hypokalemia16.530951726258197e-0021988-08-01T00:00:001988-08-01T00:00:00Betacoronavirus16.523119056878211e-0022020-09-10T00:00:002020-09-10T00:00:00Hirudins16.506186635570688e-0022008-05-01T00:00:002008-05-01T00:00:00Calcium-Calmodulin-Dependent Protein Kinase Type 216.430126766298938e-0022008-01-28T00:00:002008-01-28T00:00:00History, 18th Century16.419596748802975e-0022007-08-10T00:00:002007-08-10T00:00:00Bradykinin16.351045646574220e-0022007-05-30T00:00:002007-05-30T00:00:00P-Selectin16.285291842879891e-0022009-04-04T00:00:002009-04-04T00:00:00Prospective Studies96.254807496998448e-0022008-04-01T00:00:002019-08-01T00:00:00Hyperglycemia26.233104933934962e-0022011-06-16T00:00:002012-05-19T00:00:00Cell Differentiation56.207982355581809e-0022003-07-31T00:00:002014-05-22T00:00:00Phenylephrine16.203389360803712e-0022007-05-30T00:00:002007-05-30T00:00:00Gene Deletion26.176584167814916e-0022000-11-01T00:00:002006-09-15T00:00:00Cadherin 526.167985564757507e-0022013-02-28T00:00:002019-01-02T00:00:00Venules16.159157647373774e-0022006-09-21T00:00:002006-09-21T00:00:00Hyperplasia26.148744257665299e-0022005-06-15T00:00:002010-04-04T00:00:00Carbon Dioxide16.140454314674252e-0021991-04-01T00:00:001991-04-01T00:00:00Histone Deacetylases26.118310787200228e-0022006-09-28T00:00:002008-01-28T00:00:00Adenosine Diphosphate16.096665623840832e-0022007-05-30T00:00:002007-05-30T00:00:00Adiponectin16.062099617175618e-0022012-04-01T00:00:002012-04-01T00:00:00RNA46.043413658309157e-0022001-10-05T00:00:002006-04-20T00:00:00Neutrophil Infiltration16.004528002584544e-0022008-11-14T00:00:002008-11-14T00:00:00Interleukin-815.983460080721450e-0022009-04-09T00:00:002009-04-09T00:00:00p38 Mitogen-Activated Protein Kinases25.861312223960684e-0022002-12-18T00:00:002013-05-30T00:00:00Hyponatremia15.851119112389924e-0021988-08-01T00:00:001988-08-01T00:00:00Transduction, Genetic15.835700940828472e-0022008-09-11T00:00:002008-09-11T00:00:00Diabetes Complications15.793412846534919e-0022012-05-19T00:00:002012-05-19T00:00:00Calcium-Binding Proteins45.762741491297326e-0022008-11-14T00:00:002013-02-27T00:00:00Induced Pluripotent Stem Cells25.746037952185728e-0022013-07-25T00:00:002018-04-04T00:00:00Hypotension15.731940970142734e-0022011-08-01T00:00:002011-08-01T00:00:00Cytoplasm25.703604661977443e-0022005-09-19T00:00:002010-06-02T00:00:00History, 19th Century15.673195481902358e-0022007-08-10T00:00:002007-08-10T00:00:00Acetylcholine15.634839107215590e-0022007-05-30T00:00:002007-05-30T00:00:00Stress, Physiological15.600842942161974e-0022013-01-28T00:00:002013-01-28T00:00:00YY1 Transcription Factor25.586885975172783e-0022010-04-29T00:00:002019-01-12T00:00:00Phylogeny15.566829103071550e-0022013-06-01T00:00:002013-06-01T00:00:00Sulfones25.517630876377616e-0022000-12-15T00:00:002013-04-06T00:00:00Protease Inhibitors15.458724824857725e-0022008-05-01T00:00:002008-05-01T00:00:00Mutagenesis, Site-Directed25.439414823373825e-0022002-03-01T00:00:002012-01-10T00:00:00Cyclic AMP Response Element-Binding Protein25.431787313279513e-0022002-03-01T00:00:002009-11-23T00:00:00Internal Medicine15.419191321417783e-0022012-03-01T00:00:002012-03-01T00:00:00Mice, 129 Strain25.407216950387973e-0022014-07-09T00:00:002016-04-29T00:00:00Immunoconjugates15.405031323885606e-0022013-01-30T00:00:002013-01-30T00:00:00Diabetes Mellitus35.378717281310006e-0022011-02-01T00:00:002014-07-09T00:00:00Middle Aged185.373560116286898e-0021992-06-01T00:00:002020-09-10T00:00:00Oxygen Consumption15.373207694111209e-0021991-04-01T00:00:001991-04-01T00:00:00PubMed15.368216690024751e-0022005-05-01T00:00:002005-05-01T00:00:00Bone Marrow Transplantation15.366791964207138e-0021992-06-01T00:00:001992-06-01T00:00:00Interleukin-115.352795086394081e-0022008-04-01T00:00:002008-04-01T00:00:00Intercellular Signaling Peptides and Proteins25.338848130928055e-0022008-08-01T00:00:002008-11-14T00:00:00Tumor Suppressor Proteins25.331384808851072e-0022003-12-01T00:00:002005-06-15T00:00:00Lectins15.323252449195642e-0022006-09-21T00:00:002006-09-21T00:00:00Aged165.290850730055294e-0021988-08-01T00:00:002020-09-10T00:00:00Chromosomes, Human, Pair 2115.290485667352894e-0022004-09-23T00:00:002004-09-23T00:00:00Urokinase-Type Plasminogen Activator15.267979199227396e-0022005-04-15T00:00:002005-04-15T00:00:00Mice, Inbred Strains15.209046245737491e-0022006-09-07T00:00:002006-09-07T00:00:00Sequence Analysis, DNA25.086061330771537e-0022002-03-01T00:00:002007-05-10T00:00:00Oligodeoxyribonucleotides15.074224348934162e-0022005-03-03T00:00:002005-03-03T00:00:00Hematopoietic Stem Cells25.047511387828602e-0021992-06-01T00:00:002015-12-30T00:00:00Hyaluronan Receptors15.047383447983166e-0022005-09-19T00:00:002005-09-19T00:00:00Carrier Proteins24.992655976080306e-0022003-10-08T00:00:002008-11-14T00:00:00Infections14.966570019265222e-0022010-06-12T00:00:002010-06-12T00:00:00Coronavirus Infections14.937665464521141e-0022020-09-10T00:00:002020-09-10T00:00:00Protein Kinase C zeta14.934128251276230e-0022002-12-18T00:00:002002-12-18T00:00:00Receptors, Thrombin14.933309936584612e-0022003-10-09T00:00:002003-10-09T00:00:00Animals, Newborn24.914346797543606e-0021997-09-08T00:00:002000-03-13T00:00:00Pneumonia, Viral14.886424831975431e-0022020-09-10T00:00:002020-09-10T00:00:00Vasodilator Agents14.874660214561580e-0022007-05-30T00:00:002007-05-30T00:00:00Cell Cycle Proteins24.865587172670530e-0022003-12-01T00:00:002005-06-15T00:00:00Vasoconstrictor Agents14.863333070270397e-0022007-05-30T00:00:002007-05-30T00:00:00Nonmuscle Myosin Type IIB14.783053895950791e-0022002-08-01T00:00:002002-08-01T00:00:00Lipoproteins, LDL14.756123824641870e-0022006-02-03T00:00:002006-02-03T00:00:00Biomechanical Phenomena14.739975907277046e-0022010-05-20T00:00:002010-05-20T00:00:00Benzopyrans14.715382102917122e-0022002-12-18T00:00:002002-12-18T00:00:00DNA34.711988566531263e-0022000-11-29T00:00:002007-05-10T00:00:00Protein Kinase C-delta14.704463539274818e-0022002-12-18T00:00:002002-12-18T00:00:00Culture Media, Serum-Free14.677037962461885e-0022002-06-28T00:00:002002-06-28T00:00:00Drug Design24.662824498194574e-0022001-07-01T00:00:002013-01-30T00:00:00Cell Movement44.645541663224211e-0022000-12-15T00:00:002014-07-09T00:00:00Staining and Labeling14.617746415415871e-0022006-09-21T00:00:002006-09-21T00:00:00MAP Kinase Kinase 214.600081345547941e-0022002-06-28T00:00:002002-06-28T00:00:00Genes, Synthetic14.540141251316458e-0022002-06-28T00:00:002002-06-28T00:00:00Feedback, Physiological14.522698454591463e-0022024-07-10T00:00:002024-07-10T00:00:00Cysteine Endopeptidases24.519497784286640e-0022000-01-01T00:00:002001-12-01T00:00:00Cell Proliferation34.483928760505133e-0022005-06-15T00:00:002024-07-10T00:00:00Financing, Government14.405388681642136e-0022005-05-01T00:00:002005-05-01T00:00:00Academic Medical Centers14.399755862636112e-0022012-03-01T00:00:002012-03-01T00:00:00Angiogenesis Inhibitors14.388133888969743e-0022012-01-01T00:00:002012-01-01T00:00:00Polymerase Chain Reaction34.381363130754295e-0021995-05-09T00:00:002011-04-04T00:00:00Transplantation, Heterologous14.326848860924010e-0022008-06-02T00:00:002008-06-02T00:00:00History, 21st Century14.316613099114038e-0022007-08-10T00:00:002007-08-10T00:00:00Histone Deacetylase Inhibitors14.314132964040649e-0022006-09-28T00:00:002006-09-28T00:00:00Catalase14.298066716429026e-0022001-09-17T00:00:002001-09-17T00:00:00Models, Anatomic14.291104523824394e-0022005-05-09T00:00:002005-05-09T00:00:00Multienzyme Complexes24.287660928785218e-0022000-01-01T00:00:002001-12-01T00:00:00Genotype24.286125506671679e-0022012-06-22T00:00:002012-08-29T00:00:00National Institutes of Health (U.S.)14.280220866225437e-0022005-05-01T00:00:002005-05-01T00:00:00Shock14.192039843899491e-0022003-12-01T00:00:002003-12-01T00:00:00Blood Physiological Phenomena14.183404893407162e-0022000-11-01T00:00:002000-11-01T00:00:00Infarction14.179567908788486e-0022002-05-16T00:00:002002-05-16T00:00:00Xanthine Oxidase14.159715329513364e-0022000-12-15T00:00:002000-12-15T00:00:00Myosin Heavy Chains14.132057537217057e-0022002-08-01T00:00:002002-08-01T00:00:00Caspases14.131776507037417e-0022003-10-08T00:00:002003-10-08T00:00:00Free Radical Scavengers14.126962525705094e-0022001-09-17T00:00:002001-09-17T00:00:00Plasmids24.103997023009082e-0022001-10-05T00:00:002006-04-20T00:00:00Inflammation Mediators24.095001406289312e-0022003-10-09T00:00:002013-05-30T00:00:00Veins14.094315586124152e-0022005-05-09T00:00:002005-05-09T00:00:00Kinetics34.080751615505388e-0021991-04-01T00:00:002016-03-16T00:00:00Rats, Sprague-Dawley34.075130352907917e-0022001-12-01T00:00:002010-04-04T00:00:00MAP Kinase Kinase 114.074566695398091e-0022002-06-28T00:00:002002-06-28T00:00:00Analysis of Variance14.061818062440571e-0022008-10-13T00:00:002008-10-13T00:00:00Hydroxymethylglutaryl-CoA Reductase Inhibitors14.059316963579673e-0022015-07-01T00:00:002015-07-01T00:00:00Critical Illness14.053513315565334e-0022013-10-04T00:00:002013-10-04T00:00:00Consensus Sequence14.039328780279918e-0022000-11-29T00:00:002000-11-29T00:00:00Antigen-Presenting Cells14.034692439358366e-0022004-03-16T00:00:002004-03-16T00:00:00NG-Nitroarginine Methyl Ester14.028923691374182e-0022000-12-15T00:00:002000-12-15T00:00:00Mitoxantrone13.979551156010381e-0022000-05-01T00:00:002000-05-01T00:00:00Genes, Dominant13.965029430977484e-0022002-12-18T00:00:002002-12-18T00:00:00Injections, Intraperitoneal13.959900689671188e-0022000-09-01T00:00:002000-09-01T00:00:00Cell Hypoxia23.898776952130124e-0022000-01-01T00:00:002019-01-12T00:00:00History, 20th Century13.869919022698258e-0022007-08-10T00:00:002007-08-10T00:00:00Coculture Techniques23.856008452550964e-0021997-09-08T00:00:002009-04-09T00:00:00Clone Cells23.852390895872099e-0022000-03-13T00:00:002000-03-13T00:00:00Receptors, G-Protein-Coupled13.839146109231280e-0022007-08-27T00:00:002007-08-27T00:00:00Gene Expression Regulation, Neoplastic23.836435104986870e-0022002-07-12T00:00:002008-08-23T00:00:00Mitogen-Activated Protein Kinase Kinases13.829007153773799e-0022002-06-28T00:00:002002-06-28T00:00:00Peptides23.794049201730104e-0022000-01-01T00:00:002002-12-18T00:00:00Response Elements13.769606360861766e-0022000-11-01T00:00:002000-11-01T00:00:00Viscera13.765644393449891e-0022019-11-11T00:00:002019-11-11T00:00:00Phosphoinositide-3 Kinase Inhibitors13.763747759296948e-0022003-12-01T00:00:002003-12-01T00:00:005' Untranslated Regions13.754829317744167e-0022000-11-29T00:00:002000-11-29T00:00:00Disease Susceptibility13.753266437059469e-0022006-02-03T00:00:002006-02-03T00:00:003T3 Cells13.712827725771336e-0022000-11-01T00:00:002000-11-01T00:00:00Allopurinol13.705600230023677e-0022000-12-15T00:00:002000-12-15T00:00:00B-Lymphocytes13.690970636575052e-0022013-01-28T00:00:002013-01-28T00:00:00Enzyme Activation33.685050098038545e-0022003-10-08T00:00:002013-05-30T00:00:00Mitogen-Activated Protein Kinase 313.678650187984226e-0022000-09-01T00:00:002000-09-01T00:00:00Interleukin-1713.651238091653863e-0022005-03-03T00:00:002005-03-03T00:00:00GATA6 Transcription Factor13.633015645991453e-0022019-01-12T00:00:002019-01-12T00:00:00Muscle, Smooth13.627800103491214e-0022002-12-18T00:00:002002-12-18T00:00:00Mitogen-Activated Protein Kinase 113.617014139324629e-0022000-09-01T00:00:002000-09-01T00:00:00DNA Mutational Analysis13.614170350958730e-0022007-05-10T00:00:002007-05-10T00:00:00Cohort Studies43.594270001465548e-0022010-10-13T00:00:002018-11-20T00:00:00Genetic Vectors23.576919373539587e-0022001-09-17T00:00:002014-07-09T00:00:00Injections, Intravenous23.572612851971536e-0022000-05-01T00:00:002017-01-01T00:00:00Fibroblast Growth Factor 213.550279037354316e-0022000-11-01T00:00:002000-11-01T00:00:00Myocardial Reperfusion Injury13.521766678493251e-0022001-12-01T00:00:002001-12-01T00:00:00Antigen Presentation13.520890056991795e-0022004-03-16T00:00:002004-03-16T00:00:00Calcium23.482866513178744e-0022007-08-27T00:00:002010-06-02T00:00:00Microscopy, Video13.481477650799693e-0022018-09-30T00:00:002018-09-30T00:00:00Cytarabine13.478462945680781e-0022000-05-01T00:00:002000-05-01T00:00:00Sequence Deletion13.473564555299656e-0022002-06-28T00:00:002002-06-28T00:00:00Protein-Tyrosine Kinases23.455942336465558e-0022002-06-28T00:00:002009-05-20T00:00:00Morphogenesis23.453700537820437e-0022011-05-31T00:00:002012-08-29T00:00:00Immunoprecipitation23.438339009335972e-0022009-08-12T00:00:002011-05-31T00:00:00Fever13.421770473101708e-0022005-09-19T00:00:002005-09-19T00:00:00Prothrombin Time13.404745977789572e-0022018-03-12T00:00:002018-03-12T00:00:00Liver23.385758387315106e-0022000-09-01T00:00:002006-09-21T00:00:00Fatal Outcome13.333837650181638e-0022002-05-16T00:00:002002-05-16T00:00:00Insulin-Like Growth Factor I13.333390003105714e-0022005-06-15T00:00:002005-06-15T00:00:00Blood Glucose13.318676726204094e-0022012-05-19T00:00:002012-05-19T00:00:00Ribosomal Proteins13.301506528848280e-0022019-11-11T00:00:002019-11-11T00:00:00Point Mutation13.261289185968880e-0022002-06-28T00:00:002002-06-28T00:00:00Biopsy13.248959131204830e-0022009-04-04T00:00:002009-04-04T00:00:00Genome, Human13.241243040871532e-0022010-05-20T00:00:002010-05-20T00:00:00Gene Expression Regulation, Enzymologic13.233165042416637e-0022001-09-17T00:00:002001-09-17T00:00:00Adult123.231966175273313e-0021991-04-01T00:00:002020-09-10T00:00:00Gene Knockdown Techniques23.215502080575196e-0022011-05-31T00:00:002012-01-10T00:00:00Transforming Growth Factor beta113.206530502706453e-0022000-11-29T00:00:002000-11-29T00:00:00Repressor Proteins13.193914915676534e-0022008-01-28T00:00:002008-01-28T00:00:00Organ Dysfunction Scores13.193208451660894e-0022018-11-20T00:00:002018-11-20T00:00:00Receptors, Adrenergic, beta-213.156907169327448e-0021998-01-15T00:00:001998-01-15T00:00:00COVID-1933.154490389151288e-0022020-08-23T00:00:002024-07-10T00:00:00Mammals13.149189250659826e-0022022-07-01T00:00:002022-07-01T00:00:00Hepatectomy13.118921267658902e-0022000-10-01T00:00:002000-10-01T00:00:00Hypoxia13.109260654259275e-0022005-09-19T00:00:002005-09-19T00:00:00Melanoma23.096533020268107e-0022009-11-23T00:00:002013-01-30T00:00:00Allosteric Regulation13.095568550959861e-0022018-03-12T00:00:002018-03-12T00:00:00Recombinant Proteins33.089362075135312e-0021994-01-14T00:00:002013-01-30T00:00:00Antimetabolites, Antineoplastic13.079625538028757e-0022000-05-01T00:00:002000-05-01T00:00:00Coronary Thrombosis13.046366129436688e-0021999-05-20T00:00:001999-05-20T00:00:00Ribosomes13.041299948177262e-0022019-11-11T00:00:002019-11-11T00:00:00Blood Transfusion13.012857481004473e-0022003-07-01T00:00:002003-07-01T00:00:00Viral Proteins13.012029361731066e-0022003-10-08T00:00:002003-10-08T00:00:00Critical Care23.010842672286200e-0022003-12-01T00:00:002012-05-19T00:00:00Skin Neoplasms22.991941988373027e-0022009-11-23T00:00:002013-01-30T00:00:00Fibroblasts22.973861943101771e-0022014-05-22T00:00:002019-01-12T00:00:00G2 Phase12.956481322183303e-0022016-03-16T00:00:002016-03-16T00:00:00Antibodies, Monoclonal12.950359626584801e-0022013-01-30T00:00:002013-01-30T00:00:00Embryonic and Fetal Development12.905122355335396e-0021996-07-01T00:00:001996-07-01T00:00:00RNA Polymerase II12.879222136991708e-0022020-01-29T00:00:002020-01-29T00:00:00Cell Survival32.873811022079622e-0022003-10-08T00:00:002014-05-01T00:00:00Algorithms12.843319182179129e-0022016-03-16T00:00:002016-03-16T00:00:00MAP Kinase Signaling System12.841701172796066e-0022002-06-28T00:00:002002-06-28T00:00:00Dioxygenases12.832447689923724e-0022018-04-04T00:00:002018-04-04T00:00:00Stem Cells22.807572626526335e-0021996-02-01T00:00:002000-03-13T00:00:00Tumor Cells, Cultured12.793215090260160e-0022002-08-01T00:00:002002-08-01T00:00:00Molecular Dynamics Simulation12.777859289955145e-0022018-03-12T00:00:002018-03-12T00:00:00Conserved Sequence12.770820203708122e-0022018-03-12T00:00:002018-03-12T00:00:00Homeodomain Proteins12.759757668643638e-0022004-03-10T00:00:002004-03-10T00:00:00Permeability12.743644243018104e-0022017-01-19T00:00:002017-01-19T00:00:00Restriction Mapping12.720879161422030e-0021995-05-09T00:00:001995-05-09T00:00:00Cell Adhesion Molecules22.719154567746823e-0022008-11-14T00:00:002013-02-28T00:00:00Risk22.692236173160055e-0022010-03-30T00:00:002020-08-23T00:00:00Microscopy, Confocal12.682645291079119e-0022000-09-01T00:00:002000-09-01T00:00:00NF-KappaB Inhibitor alpha22.631235870585177e-0022001-12-01T00:00:002006-04-20T00:00:00Genetic Therapy22.620219254085730e-0021998-01-15T00:00:002014-07-09T00:00:00Erythroid-Specific DNA-Binding Factors12.611972345252181e-0021994-01-14T00:00:001994-01-14T00:00:00TATA Box12.598792574953702e-0021994-01-14T00:00:001994-01-14T00:00:00Mitochondria12.522077807875121e-0022007-08-27T00:00:002007-08-27T00:00:00DNA Modification Methylases12.491724647475675e-0022014-05-22T00:00:002014-05-22T00:00:00HEK293 Cells22.485381850483870e-0022011-04-04T00:00:002014-05-22T00:00:00Freezing12.477768933664831e-0022014-05-01T00:00:002014-05-01T00:00:00Incidence22.465742115917904e-0022003-07-01T00:00:002020-08-23T00:00:00Oxidative Stress12.452567373209519e-0022004-08-11T00:00:002004-08-11T00:00:00Coronary Artery Bypass12.443750076227677e-0022002-05-16T00:00:002002-05-16T00:00:00Green Fluorescent Proteins22.441422794688200e-0022003-10-08T00:00:002012-02-10T00:00:00Fluorescent Dyes12.403094966235202e-0022000-12-15T00:00:002000-12-15T00:00:00Subcellular Fractions12.376331550670904e-0022013-09-01T00:00:002013-09-01T00:00:00Drug Repositioning12.366774999138558e-0022015-07-01T00:00:002015-07-01T00:00:00GATA1 Transcription Factor12.361577947826353e-0021994-01-14T00:00:001994-01-14T00:00:00Snail Family Transcription Factors12.334558130436063e-0022012-08-29T00:00:002012-08-29T00:00:00Fas Ligand Protein12.328557703745225e-0022013-02-27T00:00:002013-02-27T00:00:00Premedication12.328177102375243e-0022013-04-06T00:00:002013-04-06T00:00:00Insulator Elements12.299795278192588e-0022012-02-10T00:00:002012-02-10T00:00:00Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha12.298710911154799e-0022014-07-09T00:00:002014-07-09T00:00:00In Vitro Techniques22.292491199747911e-0021994-01-14T00:00:002000-01-01T00:00:00Oxygen12.285034654517271e-0022003-12-01T00:00:002003-12-01T00:00:00Claudin-512.279057854389727e-0022012-01-10T00:00:002012-01-10T00:00:00Pregnancy22.264993441228976e-0021996-07-01T00:00:002013-01-28T00:00:00Chemokine CCL212.244576811664543e-0022014-07-09T00:00:002014-07-09T00:00:00Maine12.238580170235704e-0022012-03-01T00:00:002012-03-01T00:00:00Testis12.214705683376473e-0021995-05-09T00:00:001995-05-09T00:00:00Cell Line, Transformed12.207426884512959e-0022013-01-30T00:00:002013-01-30T00:00:00Immunity, Innate12.196271535934245e-0022024-07-10T00:00:002024-07-10T00:00:00Genes, Bacterial12.194504780045576e-0021995-05-09T00:00:001995-05-09T00:00:00Internship and Residency12.188884220286212e-0022012-03-01T00:00:002012-03-01T00:00:00Tissue Plasminogen Activator12.178742110488901e-0022017-01-19T00:00:002017-01-19T00:00:00Lung Diseases12.168278091596685e-0022001-11-01T00:00:002001-11-01T00:00:00beta-Globins12.163210968859470e-0022012-02-10T00:00:002012-02-10T00:00:00Peptide Library12.161686966781953e-0022013-01-30T00:00:002013-01-30T00:00:00Coronary Circulation12.159040385867926e-0021997-09-08T00:00:001997-09-08T00:00:00Ligands22.155292893021683e-0022008-05-21T00:00:002008-11-14T00:00:00Intercellular Junctions12.144598022285349e-0022012-01-10T00:00:002012-01-10T00:00:00Microdissection12.127015247387301e-0022011-05-31T00:00:002011-05-31T00:00:00Muscle Fibers, Skeletal12.094245691753654e-0022014-07-09T00:00:002014-07-09T00:00:00Brain42.092670502090697e-0022000-03-13T00:00:002019-11-11T00:00:00Statistics as Topic12.084367615087493e-0022017-01-19T00:00:002017-01-19T00:00:00Regional Blood Flow12.079893296833468e-0022014-07-09T00:00:002014-07-09T00:00:00Antibody Specificity12.079589387948712e-0022013-01-30T00:00:002013-01-30T00:00:00SARS-CoV-222.048711834577264e-0022020-09-10T00:00:002024-07-10T00:00:00RNA-Binding Proteins12.040145646986369e-0022019-11-11T00:00:002019-11-11T00:00:00Hep G2 Cells12.031903259154454e-0022011-09-12T00:00:002011-09-12T00:00:00Egtazic Acid12.022359024643840e-0022010-06-02T00:00:002010-06-02T00:00:00Peroxidase22.006995623362798e-0022001-12-01T00:00:002005-03-03T00:00:00Platelet Count11.997451513307556e-0022013-02-27T00:00:002013-02-27T00:00:00Rosiglitazone11.983049910309223e-0022010-06-02T00:00:002010-06-02T00:00:00Tumor Necrosis Factor alpha-Induced Protein 311.963405517658062e-0022010-04-04T00:00:002010-04-04T00:00:00U937 Cells11.951213973692884e-0022010-04-04T00:00:002010-04-04T00:00:00Chromatin Assembly and Disassembly11.927558919796008e-0022014-05-22T00:00:002014-05-22T00:00:00Dyrk Kinases11.915239959374900e-0022009-05-20T00:00:002009-05-20T00:00:00Ions11.910639962289864e-0022010-06-02T00:00:002010-06-02T00:00:00Clinical Trials as Topic11.906419126405314e-0022006-01-01T00:00:002006-01-01T00:00:00ErbB Receptors11.905581831999420e-0022000-09-01T00:00:002000-09-01T00:00:00Pyrazoles21.898644619712741e-0022008-01-28T00:00:002013-05-30T00:00:00Cell Line, Tumor11.896892796064605e-0022006-09-07T00:00:002006-09-07T00:00:00Academies and Institutes11.892728718553975e-0022012-03-01T00:00:002012-03-01T00:00:00Neointima11.887984959407632e-0022010-04-04T00:00:002010-04-04T00:00:00Myocardial Ischemia11.884715912712988e-0022000-01-01T00:00:002000-01-01T00:00:00Catechols11.883590988230138e-0022009-05-20T00:00:002009-05-20T00:00:00Angiopoietin-111.844701692621941e-0022009-08-12T00:00:002009-08-12T00:00:00Growth Arrest-Specific Protein 611.821782754227792e-0022008-08-01T00:00:002008-08-01T00:00:00Leukocyte Rolling11.811218440012844e-0022008-11-14T00:00:002008-11-14T00:00:00Cell Death11.807204645784280e-0022014-05-01T00:00:002014-05-01T00:00:00Heart Diseases11.785249918962211e-0022001-11-01T00:00:002001-11-01T00:00:00Keratinocytes11.779995824017290e-0022013-02-28T00:00:002013-02-28T00:00:00National Heart, Lung, and Blood Institute (U.S.)11.779334021071197e-0022010-03-30T00:00:002010-03-30T00:00:00Biological Transport11.768999396864499e-0022013-01-30T00:00:002013-01-30T00:00:00Hospitals, University11.756366371693822e-0022010-06-12T00:00:002010-06-12T00:00:00Histones11.745399772732234e-0022019-01-12T00:00:002019-01-12T00:00:00Hospitals, Urban11.741871360312751e-0022010-06-12T00:00:002010-06-12T00:00:00Tyrphostins11.737599464510104e-0022008-01-28T00:00:002008-01-28T00:00:00Skin11.733556233120106e-0022002-03-01T00:00:002002-03-01T00:00:00Hemodynamics11.721402249855133e-0022018-11-20T00:00:002018-11-20T00:00:00Coronary Disease11.705070051298717e-0022002-05-16T00:00:002002-05-16T00:00:00Aged, 80 and over41.694796225610407e-0021988-08-01T00:00:002020-09-10T00:00:00Stromal Cells11.693662446101087e-0022013-05-30T00:00:002013-05-30T00:00:00Nitriles11.687242158541757e-0022013-04-06T00:00:002013-04-06T00:00:00Chromatography, Gel11.659288371140791e-0022008-05-21T00:00:002008-05-21T00:00:00Lymphocyte Function-Associated Antigen-111.645768965189738e-0022008-11-14T00:00:002008-11-14T00:00:00Inositol 1,4,5-Trisphosphate Receptors11.642412671425403e-0022007-08-27T00:00:002007-08-27T00:00:00Cerebrovascular Circulation11.627439433666315e-0021997-09-08T00:00:001997-09-08T00:00:00Thiazolidinediones11.627112319304341e-0022010-06-02T00:00:002010-06-02T00:00:00Receptors, Cytoplasmic and Nuclear11.625745494854869e-0022011-09-12T00:00:002011-09-12T00:00:00Receptor, PAR-111.624680738546601e-0022007-08-27T00:00:002007-08-27T00:00:00High-Throughput Nucleotide Sequencing11.610081523883036e-0022019-11-11T00:00:002019-11-11T00:00:00Interleukin-1beta11.606921313112080e-0022013-04-06T00:00:002013-04-06T00:00:00Calmodulin11.600921933260689e-0022008-01-28T00:00:002008-01-28T00:00:00Diagnosis, Differential11.600827747573155e-0022002-05-16T00:00:002002-05-16T00:00:00Lasers11.600236904312026e-0022011-05-31T00:00:002011-05-31T00:00:00Single-Cell Analysis11.594381708273913e-0022019-11-11T00:00:002019-11-11T00:00:00High-Throughput Screening Assays11.584895455085801e-0022013-01-30T00:00:002013-01-30T00:00:00E1A-Associated p300 Protein11.583368706826364e-0022008-01-28T00:00:002008-01-28T00:00:00Pulmonary Embolism11.582924239970557e-0022020-08-23T00:00:002020-08-23T00:00:00Histone Deacetylase 311.579626895840707e-0022006-09-28T00:00:002006-09-28T00:00:00Leupeptins11.572773384599471e-0022006-09-28T00:00:002006-09-28T00:00:00Cytoskeleton11.567805735410741e-0022012-01-10T00:00:002012-01-10T00:00:00Hospitalization21.567380934079379e-0022012-05-19T00:00:002020-08-23T00:00:00Nucleic Acid Conformation11.562501872175020e-0022010-04-29T00:00:002010-04-29T00:00:00Practice Guidelines as Topic11.561037261218331e-0022004-03-01T00:00:002004-03-01T00:00:00Microfilament Proteins11.541952676829570e-0022011-09-12T00:00:002011-09-12T00:00:00Hematopoiesis11.541604594950307e-0022015-12-30T00:00:002015-12-30T00:00:00Hydrogen-Ion Concentration11.538163086994765e-0021991-04-01T00:00:001991-04-01T00:00:00Peritonitis11.536204382985201e-0022008-11-14T00:00:002008-11-14T00:00:00Bronchoalveolar Lavage Fluid11.527244110276171e-0022008-11-14T00:00:002008-11-14T00:00:00Superoxides11.518512385586628e-0022007-08-27T00:00:002007-08-27T00:00:00Leukemia, Myelogenous, Chronic, BCR-ABL Positive11.502324978286053e-0021991-04-01T00:00:001991-04-01T00:00:00Heart Rate11.489388510118643e-0021998-01-15T00:00:001998-01-15T00:00:00Electrophoresis, Polyacrylamide Gel11.481674229034255e-0022008-05-21T00:00:002008-05-21T00:00:00Cell Culture Techniques11.464630291005632e-0022013-07-25T00:00:002013-07-25T00:00:00Antibodies, Neutralizing11.459811306369399e-0022015-12-30T00:00:002015-12-30T00:00:00Histone Acetyltransferases11.454788762581873e-0022008-01-28T00:00:002008-01-28T00:00:00Diuretics11.428342332441582e-0021988-08-01T00:00:001988-08-01T00:00:00Interleukin-23 Subunit p1911.421789939665930e-0022005-03-03T00:00:002005-03-03T00:00:00Prognosis21.419978105695278e-0022010-03-30T00:00:002020-09-10T00:00:00Chickens11.406949863607698e-0022007-08-27T00:00:002007-08-27T00:00:00Mice, Nude11.388784964348674e-0022011-05-31T00:00:002011-05-31T00:00:00Gene Dosage11.384505532380903e-0022009-05-20T00:00:002009-05-20T00:00:00Retrospective Studies31.356006995919160e-0021992-06-01T00:00:002020-09-10T00:00:00Azepines11.352917918644180e-0022006-09-28T00:00:002006-09-28T00:00:00Ischemia11.349817610246890e-0022014-07-09T00:00:002014-07-09T00:00:00Leukemia, Myeloid, Acute11.342027992656537e-0022000-05-01T00:00:002000-05-01T00:00:00Sensitivity and Specificity11.340172941711499e-0022019-11-11T00:00:002019-11-11T00:00:00Myocardial Infarction21.323509680890433e-0022000-01-01T00:00:002002-05-16T00:00:00Rats, Long-Evans11.316551401939324e-0022005-03-03T00:00:002005-03-03T00:00:00Proteasome Endopeptidase Complex21.308976801893981e-0022000-01-01T00:00:002001-12-01T00:00:00Cardiovascular Diseases11.297719178150199e-0022010-03-30T00:00:002010-03-30T00:00:00Endoplasmic Reticulum11.295814606091074e-0022010-06-02T00:00:002010-06-02T00:00:00Enzyme-Linked Immunosorbent Assay11.295497800322935e-0022011-02-01T00:00:002011-02-01T00:00:00CASP8 and FADD-Like Apoptosis Regulating Protein11.291107754101155e-0022003-10-08T00:00:002003-10-08T00:00:00Vaccinia11.284040973051680e-0022004-03-16T00:00:002004-03-16T00:00:00Hypoglycemia11.282046855701105e-0022011-06-16T00:00:002011-06-16T00:00:00Anoikis11.270905150040485e-0022003-10-08T00:00:002003-10-08T00:00:00Program Evaluation11.268601804199533e-0022012-03-01T00:00:002012-03-01T00:00:00Hydroxamic Acids11.260431755284428e-0022006-09-28T00:00:002006-09-28T00:00:00Interleukin-2311.247519296282944e-0022005-03-03T00:00:002005-03-03T00:00:00Caspase 911.245195008317161e-0022003-10-08T00:00:002003-10-08T00:00:00Isoenzymes11.244926446513528e-0022008-01-28T00:00:002008-01-28T00:00:00GATA4 Transcription Factor11.242283918747403e-0022004-03-10T00:00:002004-03-10T00:00:00DNA Fragmentation11.226501445787862e-0022003-10-08T00:00:002003-10-08T00:00:00Caspase 811.222802862224448e-0022003-10-08T00:00:002003-10-08T00:00:00Escherichia coli11.216270930324847e-0021995-05-09T00:00:001995-05-09T00:00:00Regression Analysis11.211442257072536e-0022012-05-19T00:00:002012-05-19T00:00:00Genetic Loci11.201174654279127e-0022012-02-10T00:00:002012-02-10T00:00:00Calcium Signaling11.200423974853885e-0022007-08-27T00:00:002007-08-27T00:00:00Acute Disease11.185765341597352e-0022013-05-30T00:00:002013-05-30T00:00:00Vaccinia virus11.181439198608283e-0022004-03-16T00:00:002004-03-16T00:00:00Anti-Bacterial Agents11.179131314984382e-0022001-12-01T00:00:002001-12-01T00:00:00Interleukin-1211.165712030829697e-0022005-03-03T00:00:002005-03-03T00:00:00Growth Substances11.093839300268796e-0022003-10-08T00:00:002003-10-08T00:00:00Trachea11.093712157509110e-0022008-01-28T00:00:002008-01-28T00:00:00Quinazolines11.092130519563529e-0022008-01-28T00:00:002008-01-28T00:00:00Neoplasm Recurrence, Local11.075416709000430e-0022000-05-01T00:00:002000-05-01T00:00:00Manometry11.073687924574163e-0022003-12-01T00:00:002003-12-01T00:00:00Antiphospholipid Syndrome11.072047934036274e-0022003-01-01T00:00:002003-01-01T00:00:00Forecasting11.065939551831063e-0022010-03-30T00:00:002010-03-30T00:00:00Pyridines11.058872082835898e-0022013-05-30T00:00:002013-05-30T00:00:00United States21.056749655788762e-0022005-05-01T00:00:002010-03-30T00:00:00Luminescent Proteins11.038923556436986e-0022003-10-08T00:00:002003-10-08T00:00:00Zinc Fingers11.037296342886770e-0022003-01-23T00:00:002003-01-23T00:00:00Pandemics11.035995924197436e-0022020-09-10T00:00:002020-09-10T00:00:00RNA Interference11.035906657587090e-0022009-04-09T00:00:002009-04-09T00:00:00Risk Factors11.030044830119365e-0022008-03-24T00:00:002008-03-24T00:00:00Kidney Diseases11.005862490388842e-0022011-06-16T00:00:002011-06-16T00:00:00CpG Islands19.907032345179668e-0032005-03-03T00:00:002005-03-03T00:00:00Antibodies19.903322340707153e-0032008-01-28T00:00:002008-01-28T00:00:00Interleukins19.874831866620972e-0032005-03-03T00:00:002005-03-03T00:00:00Thymus Gland19.866611138475982e-0032005-03-03T00:00:002005-03-03T00:00:00Autoantigens19.772789247598888e-0032004-03-16T00:00:002004-03-16T00:00:00Genetic Carrier Screening19.452670954878369e-0032000-03-13T00:00:002000-03-13T00:00:00Leukemia, Lymphocytic, Chronic, B-Cell19.427856851485074e-0031991-04-01T00:00:001991-04-01T00:00:00Boston19.417344481122320e-0032012-05-19T00:00:002012-05-19T00:00:00Hypoxia-Inducible Factor 119.293236417449955e-0032000-01-01T00:00:002000-01-01T00:00:00Follow-Up Studies19.092831092022472e-0032020-09-10T00:00:002020-09-10T00:00:00Age Factors29.029981149267201e-0032000-05-01T00:00:002009-07-13T00:00:00Spectroscopy, Near-Infrared19.008228596036800e-0032003-12-01T00:00:002003-12-01T00:00:00Tomography, X-Ray Computed18.942497884782567e-0032002-05-16T00:00:002002-05-16T00:00:00Hypoglycemic Agents18.939093958669427e-0032012-05-19T00:00:002012-05-19T00:00:00Antineoplastic Combined Chemotherapy Protocols18.933573846200655e-0032000-05-01T00:00:002000-05-01T00:00:00Skin Transplantation18.869006558984297e-0032004-03-16T00:00:002004-03-16T00:00:00Odds Ratio18.811344060608902e-0032010-06-12T00:00:002010-06-12T00:00:00Multivariate Analysis18.791837236032621e-0032011-08-01T00:00:002011-08-01T00:00:00Ubiquitins18.772479318155781e-0032000-01-01T00:00:002000-01-01T00:00:00Adolescent28.701388780145055e-0031992-06-01T00:00:002020-09-10T00:00:00Receptors, Platelet-Derived Growth Factor18.684458772250617e-0031998-08-15T00:00:001998-08-15T00:00:00Curriculum18.657595851512568e-0032012-03-01T00:00:002012-03-01T00:00:00Cell Separation18.627454903511118e-0032003-10-08T00:00:002003-10-08T00:00:00Insulin18.449066491411819e-0032012-05-19T00:00:002012-05-19T00:00:00Cerebellar Diseases18.373241806876380e-0032000-05-01T00:00:002000-05-01T00:00:00Case-Control Studies18.293893581061718e-0032015-07-01T00:00:002015-07-01T00:00:00Antineoplastic Agents18.133671032690968e-0032000-05-01T00:00:002000-05-01T00:00:00Attitude of Health Personnel18.132124051672105e-0032012-03-01T00:00:002012-03-01T00:00:00Genomics18.069535280687554e-0032013-10-04T00:00:002013-10-04T00:00:00Protein Structure, Tertiary17.970095331954719e-0032003-10-08T00:00:002003-10-08T00:00:00Drug Eruptions17.945329851564537e-0032000-05-01T00:00:002000-05-01T00:00:00Logistic Models17.894584658165177e-0032011-06-16T00:00:002011-06-16T00:00:00Comorbidity17.872989868610181e-0032011-06-16T00:00:002011-06-16T00:00:00RNA, Complementary17.863561613778001e-0031996-07-01T00:00:001996-07-01T00:00:00Microscopy, Fluorescence17.741025653181985e-0032003-10-08T00:00:002003-10-08T00:00:00Extraembryonic Membranes17.725436697357176e-0031996-07-01T00:00:001996-07-01T00:00:00Receptor, Platelet-Derived Growth Factor alpha17.678383712026960e-0031998-08-15T00:00:001998-08-15T00:00:00Pulmonary Disease, Chronic Obstructive17.620980134366450e-0032011-06-16T00:00:002011-06-16T00:00:00Hypoxia-Inducible Factor 1, alpha Subunit17.351773130186380e-0032000-01-01T00:00:002000-01-01T00:00:00Exanthema17.307593052780387e-0032000-05-01T00:00:002000-05-01T00:00:00Endoderm17.299879190667429e-0031996-07-01T00:00:001996-07-01T00:00:00Research17.225513335560607e-0032003-12-01T00:00:002003-12-01T00:00:00Pyrimidines17.088415437201156e-0032008-01-28T00:00:002008-01-28T00:00:00Neutropenia16.860072254548347e-0032000-05-01T00:00:002000-05-01T00:00:00Trophoblasts16.651228923360443e-0031996-07-01T00:00:001996-07-01T00:00:00Remission Induction16.649926026467499e-0032000-05-01T00:00:002000-05-01T00:00:00Predictive Value of Tests16.367573582971464e-0032010-06-12T00:00:002010-06-12T00:00:00Young Adult16.174735059244379e-0032020-09-10T00:00:002020-09-10T00:00:00Phosphoproteins15.971426972174258e-0032001-12-01T00:00:002001-12-01T00:00:00Myocardial Contraction15.827352868312744e-0031998-01-15T00:00:001998-01-15T00:00:00Risk Assessment15.654123941032908e-0032013-10-04T00:00:002013-10-04T00:00:00Death, Sudden, Cardiac15.534860870796647e-0032000-05-01T00:00:002000-05-01T00:00:00Recombination, Genetic15.399042393462748e-0031996-02-01T00:00:001996-02-01T00:00:00Survival Rate15.195320287836660e-0032005-03-03T00:00:002005-03-03T00:00:00Wounds and Injuries15.092297451132944e-0032003-12-01T00:00:002003-12-01T00:00:00Swine15.047150527170115e-0032000-01-01T00:00:002000-01-01T00:00:00Disease-Free Survival14.894562863631466e-0032000-05-01T00:00:002000-05-01T00:00:00Cause of Death14.802615598550936e-0032000-05-01T00:00:002000-05-01T00:00:00Feasibility Studies14.439566082814648e-0032000-03-13T00:00:002000-03-13T00:00:00Ventricular Function, Left14.420741670803198e-0032001-12-01T00:00:002001-12-01T00:00:00Placenta13.994470317650312e-0031996-07-01T00:00:001996-07-01T00:00:00T-Lymphocytes13.738496180434223e-0032004-03-16T00:00:002004-03-16T00:00:00Child13.182056602991149e-0031992-06-01T00:00:001992-06-01T00:00:00Treatment Outcome11.521690212066090e-0032000-05-01T00:00:002000-05-01T00:00:00Syed Muhammad Ali Akbar, M.B.,B.S.Syed Muhammad AliAkbar

Beth Israel Deaconess Medical CenterDana 501330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyResearch Fellow in MedicineFellow or Post DocSerkan Akbas, M.D.SerkanAkbas

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/31222785Superb Microvascular Imaging Compared With Power Doppler Ultrasound in Assessing Synovitis of the Knee in Juvenile Idiopathic Arthritis: A Preliminary Study. J Ultrasound Med. 2020 Jan; 39(1):99-106.Alis D, Erol BC, Akbas S, Barut K, Kasapcopur O, Adaletli I. J Ultrasound Med2020 Jan39(1):99-106http://www.ncbi.nlm.nih.gov/pubmed/30777674Increased vein wall thickness in Behçet disease. J Vasc Surg Venous Lymphat Disord. 2019 09; 7(5):677-684.e2.Seyahi E, Gjoni M, Durmaz ES, Akbas S, Sut N, Dikici AS, Mihmanli I, Yazici H. J Vasc Surg Venous Lymphat Disord2019 097(5):677-684.e2http://www.ncbi.nlm.nih.gov/pubmed/30027586Shear Wave Elastography in the Evaluation of the Kidneys in Pediatric Patients with Unilateral Vesicoureteral Reflux. J Ultrasound Med. 2019 Feb; 38(2):379-385.Kalyoncu Ucar A, Cicek RY, Alis D, Akbas S, Arioz Habibi H, Arslan MU, Eral G, Suleyman A, Caliskan S, Adaletli I. J Ultrasound Med2019 Feb38(2):379-385http://www.ncbi.nlm.nih.gov/pubmed/28258641Amyloid Goiter: A Diagnosis to Consider in Diffuse Fatty Infiltration of the Thyroid. J Ultrasound Med. 2017 May; 36(5):1045-1049.Bakan S, Kandemirli SG, Akbas S, Cingoz M, Ozcan Guzelbey B, Kantarci F, Akman C. J Ultrasound Med2017 May36(5):1045-1049http://www.ncbi.nlm.nih.gov/pubmed/27138071CT and MR imaging features of diffuse lipomatosis of the abdomen. Diagn Interv Imaging. 2016 Nov; 97(11):1189-1191.Ure E, Cingoz M, Kandemirli SG, Akbas S, Tutar O, Ogut AG. Diagn Interv Imaging2016 Nov97(11):1189-1191Ultrasonography, Doppler22.495420911075869e-0012019-02-15T00:00:002019-06-20T00:00:00Femoral Vein11.399407875132750e-0012019-02-15T00:00:002019-02-15T00:00:00Behcet Syndrome11.370635753398432e-0012019-02-15T00:00:002019-02-15T00:00:00Synovitis11.328122458804685e-0012019-06-20T00:00:002019-06-20T00:00:00Familial Mediterranean Fever11.251639380665549e-0012017-03-04T00:00:002017-03-04T00:00:00Saphenous Vein11.158368190437052e-0012019-02-15T00:00:002019-02-15T00:00:00Vesico-Ureteral Reflux11.076569256795667e-0012018-07-19T00:00:002018-07-19T00:00:00Lipoma11.039084743030100e-0012016-04-29T00:00:002016-04-29T00:00:00Arthritis, Juvenile11.034183159491318e-0012019-06-20T00:00:002019-06-20T00:00:00Elasticity Imaging Techniques19.630050655083666e-0022018-07-19T00:00:002018-07-19T00:00:00Intestinal Diseases18.705440636883294e-0022016-04-29T00:00:002016-04-29T00:00:00Thyroid Gland17.893714808148702e-0022017-03-04T00:00:002017-03-04T00:00:00Abdomen17.681791650650308e-0022016-04-29T00:00:002016-04-29T00:00:00Venous Thrombosis17.509528320613730e-0022019-02-15T00:00:002019-02-15T00:00:00Amyloidosis17.426355931178692e-0022017-03-04T00:00:002017-03-04T00:00:00Image Interpretation, Computer-Assisted16.050549548525414e-0022019-06-20T00:00:002019-06-20T00:00:00Image Enhancement15.795415965497536e-0022016-04-29T00:00:002016-04-29T00:00:00Adipose Tissue15.519397526298520e-0022017-03-04T00:00:002017-03-04T00:00:00Kidney14.766100329746553e-0022018-07-19T00:00:002018-07-19T00:00:00Diagnostic Imaging14.764447680705500e-0022017-03-04T00:00:002017-03-04T00:00:00Goiter13.170794210383941e-0022017-03-04T00:00:002017-03-04T00:00:00Reproducibility of Results33.075910148884650e-0022018-07-19T00:00:002019-06-20T00:00:00Tomography, X-Ray Computed22.976221432500244e-0022016-04-29T00:00:002017-03-04T00:00:00Hypertrophy12.809983172642945e-0022017-03-04T00:00:002017-03-04T00:00:00Microvessels12.715276086685030e-0022019-06-20T00:00:002019-06-20T00:00:00Observer Variation12.393655035837305e-0022019-02-15T00:00:002019-02-15T00:00:00Intestinal Obstruction12.295459310481866e-0022016-04-29T00:00:002016-04-29T00:00:00Magnetic Resonance Imaging22.232415558456085e-0022016-04-29T00:00:002017-03-04T00:00:00Diagnosis, Differential22.169286262402971e-0022016-04-29T00:00:002017-03-04T00:00:00Knee Joint12.029986376539436e-0022019-06-20T00:00:002019-06-20T00:00:00Child, Preschool21.439619978862167e-0022018-07-19T00:00:002019-06-20T00:00:00Ultrasonography11.270393359692578e-0022017-03-04T00:00:002017-03-04T00:00:00Male51.169505989772057e-0022016-04-29T00:00:002019-06-20T00:00:00Predictive Value of Tests11.162083979598225e-0022019-02-15T00:00:002019-02-15T00:00:00Child21.005396925912278e-0022018-07-19T00:00:002019-06-20T00:00:00Adolescent29.908030663149315e-0032018-07-19T00:00:002019-06-20T00:00:00Female49.121676026854748e-0032017-03-04T00:00:002019-06-20T00:00:00Middle Aged38.660327242954560e-0032016-04-29T00:00:002019-02-15T00:00:00Humans57.698461735561176e-0032016-04-29T00:00:002019-06-20T00:00:00Cohort Studies17.685417074111725e-0032019-06-20T00:00:002019-06-20T00:00:00Prospective Studies16.303998479474678e-0032018-07-19T00:00:002018-07-19T00:00:00Adult26.015890219434146e-0032017-03-04T00:00:002019-02-15T00:00:00Retrospective Studies14.751062421571939e-0032019-02-15T00:00:002019-02-15T00:00:00Vimal K. Akhouri, M.B.,B.S., M.D.VimalAkhouri

Beth Israel Deaconess Med CtrAnesthesia & Critical Care330 Brookline AveBoston, MA 02215617/667-311242.34022770000000-71.10585400000000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaAssistant Professor of AnaesthesiaAssistant Professorhttp://www.ncbi.nlm.nih.gov/pubmed/30723060Transversus abdominis plane block reduces pain and narcotic consumption after robot-assisted distal pancreatectomy. HPB (Oxford). 2019 08; 21(8):1039-1045.Solis-Velasco MA, Ore Carranza AS, Stackhouse KA, Verkoulen K, Watkins AA, Akhouri V, Callery MP, Kent TS, James Moser A. HPB (Oxford)2019 0821(8):1039-1045http://www.ncbi.nlm.nih.gov/pubmed/21668751Intra- and postoperative very low dose intravenous ketamine infusion does not increase pain relief after major spine surgery in patients with preoperative narcotic analgesic intake. Pain Med. 2011 Aug; 12(8):1276-83.Subramaniam K, Akhouri V, Glazer PA, Rachlin J, Kunze L, Cronin M, Desilva D, Asdourian CP, Steinbrook RA. Pain Med2011 Aug12(8):1276-83http://www.ncbi.nlm.nih.gov/pubmed/12482217Labetalol for prophylactic treatment of intractable migraine during pregnancy. Headache. 2002 Jul-Aug; 42(7):642-5.Dey R, Khan S, Akhouri V, Wootton J, Bajwa ZH. Headache2002 Jul-Aug42(7):642-5Abdominal Muscles11.372697265198099e-0012019-02-02T00:00:002019-02-02T00:00:00Postoperative Pain21.102981936286179e-0012011-06-13T00:00:002019-02-02T00:00:00Pancreatectomy11.040136413791298e-0012019-02-02T00:00:002019-02-02T00:00:00Nerve Block19.172292923268907e-0022019-02-02T00:00:002019-02-02T00:00:00Robotic Surgical Procedures17.592790038753156e-0022019-02-02T00:00:002019-02-02T00:00:00Narcotics17.561848363379832e-0022011-06-13T00:00:002011-06-13T00:00:00Analgesia16.330324841290885e-0022011-06-13T00:00:002011-06-13T00:00:00Ketamine15.549859333437111e-0022011-06-13T00:00:002011-06-13T00:00:00Analgesics15.296412116933231e-0022011-06-13T00:00:002011-06-13T00:00:00Spine15.175458454807679e-0022011-06-13T00:00:002011-06-13T00:00:00Labetalol14.736092289856968e-0022002-07-01T00:00:002002-07-01T00:00:00Analgesics, Opioid14.706072623666239e-0022019-02-02T00:00:002019-02-02T00:00:00Intractable Pain14.296132387673510e-0022002-07-01T00:00:002002-07-01T00:00:00Infusions, Intravenous24.202304402322447e-0022011-06-13T00:00:002019-02-02T00:00:00Bupivacaine12.921394741257690e-0022019-02-02T00:00:002019-02-02T00:00:00Pain Measurement22.796222870281075e-0022011-06-13T00:00:002019-02-02T00:00:00Statistics, Nonparametric12.504093496067504e-0022019-02-02T00:00:002019-02-02T00:00:00Chi-Square Distribution12.414821500126037e-0022019-02-02T00:00:002019-02-02T00:00:00Antihypertensive Agents12.267776173733541e-0022002-07-01T00:00:002002-07-01T00:00:00Reference Values12.243931465740241e-0022019-02-02T00:00:002019-02-02T00:00:00Drug Administration Schedule12.141641695055122e-0022019-02-02T00:00:002019-02-02T00:00:00Migraine Disorders11.915362051395188e-0022002-07-01T00:00:002002-07-01T00:00:00Pregnancy Complications11.717671272727162e-0022002-07-01T00:00:002002-07-01T00:00:00Dose-Response Relationship, Drug11.606224084156815e-0022019-02-02T00:00:002019-02-02T00:00:00Placebos11.604667587531740e-0022011-06-13T00:00:002011-06-13T00:00:00Pain Management11.569792260294359e-0022019-02-02T00:00:002019-02-02T00:00:00Postoperative Period11.532168669698994e-0022011-06-13T00:00:002011-06-13T00:00:00Databases, Factual11.222322420082556e-0022019-02-02T00:00:002019-02-02T00:00:00Adrenergic alpha-Antagonists11.139114271120147e-0022002-07-01T00:00:002002-07-01T00:00:00Case-Control Studies11.063874124824507e-0022019-02-02T00:00:002019-02-02T00:00:00Treatment Outcome28.872371742864040e-0032011-06-13T00:00:002019-02-02T00:00:00Adrenergic beta-Antagonists17.937718376788527e-0032002-07-01T00:00:002002-07-01T00:00:00Double-Blind Method17.922034592540435e-0032011-06-13T00:00:002011-06-13T00:00:00Pre-Eclampsia16.061889349153474e-0032002-07-01T00:00:002002-07-01T00:00:00Aged25.685576951198585e-0032011-06-13T00:00:002019-02-02T00:00:00Middle Aged25.088963261012052e-0032011-06-13T00:00:002019-02-02T00:00:00Retrospective Studies14.739355742266018e-0032019-02-02T00:00:002019-02-02T00:00:00Female34.493787610396164e-0032002-07-01T00:00:002019-02-02T00:00:00Male23.958948318127721e-0032011-06-13T00:00:002019-02-02T00:00:00Prospective Studies13.853962349835339e-0032011-06-13T00:00:002011-06-13T00:00:00Humans33.125391533329844e-0032002-07-01T00:00:002019-02-02T00:00:00Adult22.900310279905902e-0032002-07-01T00:00:002011-06-13T00:00:00Pregnancy12.520175275947015e-0032002-07-01T00:00:002002-07-01T00:00:00Ralph Akiki, M.D.RalphAkiki

Beth Israel Deaconess Medical CenterDivision: General Medicine330 Brookline AveBoston, MA 02215617/754-4677

1BIDMCBeth Israel Deaconess Medical CenterMedicineGeneral MedicineInstructor in MedicineInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/38332441Tropheryma whipplei Endocarditis Presenting as Valvulopathy and Multiple Septic Emboli. J Gen Intern Med. 2024 May; 39(7):1252-1256.Akiki R, Ozturk NB, Patel R, Bernacki K, Davila F. J Gen Intern Med2024 May39(7):1252-1256Tropheryma18.507819396906009e-0012024-02-08T00:00:002024-02-08T00:00:00Whipple Disease18.411803873687014e-0012024-02-08T00:00:002024-02-08T00:00:00Embolism16.576445188123848e-0012024-02-08T00:00:002024-02-08T00:00:00Endocarditis, Bacterial16.260072447111460e-0012024-02-08T00:00:002024-02-08T00:00:00Heart Valve Diseases11.221230217972505e-0012024-02-08T00:00:002024-02-08T00:00:00Aortic Valve11.010025200844152e-0012024-02-08T00:00:002024-02-08T00:00:00Anti-Bacterial Agents15.488753967318441e-0022024-02-08T00:00:002024-02-08T00:00:00Middle Aged11.813874182419575e-0022024-02-08T00:00:002024-02-08T00:00:00Male11.411099623925594e-0022024-02-08T00:00:002024-02-08T00:00:00Humans19.288790784195356e-0032024-02-08T00:00:002024-02-08T00:00:00Eloho Akpovi, M.D.ElohoAkpovi

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterObstetrics Gynecology & Repro. Bio.Instructor in Obstetrics, Gynecology and Reproductive BiologyInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/32992103Medicaid member perspectives on innovation in prenatal care delivery: A call to action from pregnant people using unscheduled care. Healthc (Amst). 2020 Dec; 8(4):100456.Akpovi EE, Carter T, Kangovi S, Srinivas SK, Bernstein JA, Mehta PK. Healthc (Amst)2020 Dec8(4):100456http://www.ncbi.nlm.nih.gov/pubmed/28625554Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome. Semin Perinatol. 2017 08; 41(5):308-317.Gadson A, Akpovi E, Mehta PK. Semin Perinatol2017 0841(5):308-317Pregnant People14.582253154986744e-0012020-08-28T00:00:002020-08-28T00:00:00Prenatal Care24.525392940062698e-0012017-07-29T00:00:002020-08-28T00:00:00Medicaid12.520918659607957e-0012020-08-28T00:00:002020-08-28T00:00:00Appointments and Schedules11.231290458182437e-0012020-08-28T00:00:002020-08-28T00:00:00Maternal Health11.092252181593293e-0012017-07-29T00:00:002017-07-29T00:00:00Social Support17.786256693625870e-0022020-08-28T00:00:002020-08-28T00:00:00Qualitative Research17.031852235476022e-0022020-08-28T00:00:002020-08-28T00:00:00Quality of Health Care15.808789243372225e-0022020-08-28T00:00:002020-08-28T00:00:00Pregnancy24.266136553440121e-0022017-07-29T00:00:002020-08-28T00:00:00Healthcare Disparities14.061639728587323e-0022017-07-29T00:00:002017-07-29T00:00:00United States22.719138361572747e-0022017-07-29T00:00:002020-08-28T00:00:00Maternal Mortality12.685089356725980e-0022017-07-29T00:00:002017-07-29T00:00:00Adult11.428474232505262e-0022020-08-28T00:00:002020-08-28T00:00:00Racial Groups11.376908402704244e-0022017-07-29T00:00:002017-07-29T00:00:00Female21.264073220263920e-0022017-07-29T00:00:002020-08-28T00:00:00Socioeconomic Factors11.246921817149099e-0022017-07-29T00:00:002017-07-29T00:00:00Ethnicity11.126725128415721e-0022017-07-29T00:00:002017-07-29T00:00:00Humans28.791523059483355e-0032017-07-29T00:00:002020-08-28T00:00:00Berk Kaan Aktas, M.D.BerkAktas

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterPathologyClinical Fellow in PathologyFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41290119Immune profiling may improve risk stratification in early-stage colorectal carcinoma. Hum Pathol. 2026 Jan; 167:105987.Oganesyan R, Aktas BK, Lee SH, Pankaj A, Yilmaz O, Patil D, Deshpande V, Yilmaz O. Hum Pathol2026 Jan167:105987Lymphocytes, Tumor-Infiltrating11.503564979171638e-0012025-11-23T00:00:002025-11-23T00:00:00Tumor Microenvironment18.923967086489917e-0022025-11-23T00:00:002025-11-23T00:00:00Colorectal Neoplasms15.696445784479359e-0022025-11-23T00:00:002025-11-23T00:00:00Biomarkers, Tumor15.496416002480385e-0022025-11-23T00:00:002025-11-23T00:00:00Tissue Array Analysis15.214833194580316e-0022025-11-23T00:00:002025-11-23T00:00:00Immunohistochemistry12.277081258332840e-0022025-11-23T00:00:002025-11-23T00:00:00Neoplasm Staging12.083908183542756e-0022025-11-23T00:00:002025-11-23T00:00:00Risk Assessment11.311360793106707e-0022025-11-23T00:00:002025-11-23T00:00:00Aged, 80 and over19.778952386052545e-0032025-11-23T00:00:002025-11-23T00:00:00Aged15.735792781787466e-0032025-11-23T00:00:002025-11-23T00:00:00Adult15.134251483150901e-0032025-11-23T00:00:002025-11-23T00:00:00Middle Aged15.133909713972143e-0032025-11-23T00:00:002025-11-23T00:00:00Male13.993914317138836e-0032025-11-23T00:00:002025-11-23T00:00:00Female13.780144137166386e-0032025-11-23T00:00:002025-11-23T00:00:00Humans12.629058492603021e-0032025-11-23T00:00:002025-11-23T00:00:00Zeynep Akyol Sari, M.D.ZeynepAkyol Sari

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyInstructor in RadiologyInstructorhttp://www.ncbi.nlm.nih.gov/pubmed/40392296Assessing the risk of unintended intestinal sampling in omental and mesenteric core needle biopsies. Eur Radiol. 2025 Nov; 35(11):7363-7371.Sari L, Rigiroli F, Akyol Sari ZN, Siewert B, Brook OR. Eur Radiol2025 Nov35(11):7363-7371http://www.ncbi.nlm.nih.gov/pubmed/38587026Thorax computed tomography (CTX) guided ground truth annotation of CHEST radiographs (CXR) for improved classification and detection of COVID-19. Int J Numer Method Biomed Eng. 2024 Jun; 40(6):e3823.Ertürk SM, Toprak T, Cömert RG, Candemir C, Cingöz E, Akyol Sari ZN, Ercan CC, Düvek E, Ersoy B, Karapinar E, Tunaci A, Selver MA. Int J Numer Method Biomed Eng2024 Jun40(6):e3823http://www.ncbi.nlm.nih.gov/pubmed/34520686Shear wave elastography evaluation of liver, pancreas, spleen and kidneys in patients with familial mediterranean fever and amyloidosis. Br J Radiol. 2021 Dec; 94(1128):20210237.Bayramoglu Z, Akyol Sari ZN, Koker O, Adaletli I, Eker Omeroglu R. Br J Radiol2021 Dec94(1128):20210237http://www.ncbi.nlm.nih.gov/pubmed/31705696Superb Microvascular Imaging in the Evaluation of Pediatric Graves Disease and Hashimoto Thyroiditis. J Ultrasound Med. 2020 May; 39(5):901-909.Bayramoglu Z, Kandemirli SG, Akyol Sari ZN, Kardelen AD, Poyrazoglu S, Bas F, Darendeliler F, Adaletli I. J Ultrasound Med2020 May39(5):901-909http://www.ncbi.nlm.nih.gov/pubmed/31031038Multi-parametric Ultrasound Evaluation of Pediatric Thyroid Dyshormonogenesis. Ultrasound Med Biol. 2019 07; 45(7):1644-1653.Adaletli I, Bayramoglu Z, Caliskan E, Yilmaz R, Akyol Sari ZN, Bas F, Kardelen AD, Poyrazoglu S, Darendeliler F. Ultrasound Med Biol2019 0745(7):1644-1653http://www.ncbi.nlm.nih.gov/pubmed/30391975Author`s Reply. Anatol J Cardiol. 2018 11; 20(5):308.Atici A, Panç C, Karaayvaz EB, Demirkiran A, Kutlu O, Kasali K, Kekeç E, Sari L, Akyol Sari ZN, Bilge AK. Anatol J Cardiol2018 1120(5):308http://www.ncbi.nlm.nih.gov/pubmed/30088483Evaluation of the Tp-Te interval, Tp-Te/QTc ratio, and QT dispersion in patients with Turner syndrome. Anatol J Cardiol. 2018 Aug; 20(2):93-99.Atici A, Panç C, Karaayvaz EB, Demirkiran A, Kutlu O, Kasali K, Kekeç E, Sari L, Akyol Sari ZN, Bilge AK. Anatol J Cardiol2018 Aug20(2):93-99Turner Syndrome22.607432372228272e-0012018-08-01T00:00:002018-11-01T00:00:00Mesentery12.117872251610654e-0012025-05-20T00:00:002025-05-20T00:00:00Omentum12.110798035438145e-0012025-05-20T00:00:002025-05-20T00:00:00Familial Mediterranean Fever11.713484642675642e-0012021-09-14T00:00:002021-09-14T00:00:00Thyroid Dysgenesis11.540666998816918e-0012019-04-25T00:00:002019-04-25T00:00:00Image-Guided Biopsy11.475174909532351e-0012025-05-20T00:00:002025-05-20T00:00:00Elasticity Imaging Techniques21.452439431254110e-0012019-04-25T00:00:002021-09-14T00:00:00Hashimoto Disease11.411239705022947e-0012019-11-09T00:00:002019-11-09T00:00:00Graves Disease11.366713633371663e-0012019-11-09T00:00:002019-11-09T00:00:00Radiography, Thoracic11.265032181950893e-0012024-04-08T00:00:002024-04-08T00:00:00Ultrasonography21.201474839663057e-0012019-04-25T00:00:002019-11-09T00:00:00Intestines11.189711990080453e-0012025-05-20T00:00:002025-05-20T00:00:00Thyroid Gland21.179629343666680e-0012019-04-25T00:00:002019-11-09T00:00:00Spleen11.129438241947643e-0012021-09-14T00:00:002021-09-14T00:00:00Microvessels11.115776664140045e-0012019-11-09T00:00:002019-11-09T00:00:00Pancreas11.091029065743305e-0012021-09-14T00:00:002021-09-14T00:00:00Amyloidosis11.016662389797249e-0012021-09-14T00:00:002021-09-14T00:00:00Heart Conduction System19.766179955290633e-0022018-08-01T00:00:002018-08-01T00:00:00Arrhythmias, Cardiac17.205484112470552e-0022018-11-01T00:00:002018-11-01T00:00:00Kidney15.931855759752508e-0022021-09-14T00:00:002021-09-14T00:00:00Liver15.770840279524846e-0022021-09-14T00:00:002021-09-14T00:00:00Tomography, X-Ray Computed25.181594849948895e-0022024-04-08T00:00:002025-05-20T00:00:00Biopsy, Large-Core Needle14.990790084901161e-0022025-05-20T00:00:002025-05-20T00:00:00SARS-CoV-214.557029050220643e-0022024-04-08T00:00:002024-04-08T00:00:00Thorax14.266492773098015e-0022024-04-08T00:00:002024-04-08T00:00:00Ultrasonography, Doppler13.242482633349335e-0022019-11-09T00:00:002019-11-09T00:00:00Ultrasonography, Interventional13.091613703949163e-0022025-05-20T00:00:002025-05-20T00:00:00COVID-1912.570075749412770e-0022024-04-08T00:00:002024-04-08T00:00:00Prospective Studies32.139652737102906e-0022019-04-25T00:00:002021-09-14T00:00:00Adolescent42.108659698366440e-0022018-08-01T00:00:002021-09-14T00:00:00Machine Learning11.773824536056034e-0022024-04-08T00:00:002024-04-08T00:00:00Female61.701206909653873e-0022018-08-01T00:00:002025-05-20T00:00:00Child31.651839793503818e-0022019-04-25T00:00:002021-09-14T00:00:00Pneumonia, Viral11.565195222310509e-0022024-04-08T00:00:002024-04-08T00:00:00Male51.556830402208663e-0022019-04-25T00:00:002025-05-20T00:00:00Echocardiography11.427261096505634e-0022018-08-01T00:00:002018-08-01T00:00:00Lung11.424130289420481e-0022024-04-08T00:00:002024-04-08T00:00:00Electrocardiography11.387937217456162e-0022018-08-01T00:00:002018-08-01T00:00:00Humans71.344330737220073e-0022018-08-01T00:00:002025-05-20T00:00:00Pandemics11.327380182153708e-0022024-04-08T00:00:002024-04-08T00:00:00Reproducibility of Results11.084103018843578e-0022019-11-09T00:00:002019-11-09T00:00:00Aged21.066014675567291e-0022024-04-08T00:00:002025-05-20T00:00:00Middle Aged29.541528619216019e-0032024-04-08T00:00:002025-05-20T00:00:00Aged, 80 and over19.438006130517419e-0032025-05-20T00:00:002025-05-20T00:00:00Cross-Sectional Studies17.816739746109481e-0032018-08-01T00:00:002018-08-01T00:00:00Retrospective Studies17.331573445291497e-0032025-05-20T00:00:002025-05-20T00:00:00Adult14.586919619930776e-0032024-04-08T00:00:002024-04-08T00:00:00Ra'ad Al-Faouri, M.D.Ra'adAl-Faouri

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryClinical Fellow in SurgeryFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/38830219Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer : A Decision Model Analysis. Ann Intern Med. 2024 Jul; 177(7):871-881.Gulati R, Jiao B, Al-Faouri R, Sharma V, Kaul S, Fleishman A, Wymer K, Boorjian SA, Olumi AF, Etzioni R, Gershman B. Ann Intern Med2024 Jul177(7):871-881http://www.ncbi.nlm.nih.gov/pubmed/38606616Enhanced prostatic Esr1+ luminal epithelial cells in the absence of SRD5A2. J Pathol. 2024 07; 263(3):300-314.Sharkey C, Long X, Al-Faouri R, Strand D, Olumi AF, Wang Z. J Pathol2024 07263(3):300-314http://www.ncbi.nlm.nih.gov/pubmed/38239633Impact of smoking status on health-related quality of life (HRQoL) in cancer survivors. Front Oncol. 2023; 13:1261041.Nolazco JI, Rosner BA, Roebuck EH, Bergerot CD, Rammant E, Iyer GS, Tang Y, Al-Faouri R, Filipas DK, Leapman MS, Mossanen M, Chang SL. Front Oncol202313:1261041http://www.ncbi.nlm.nih.gov/pubmed/39492303Effect of TNF-a Inhibitor Therapy on Growth of the Prostate Gland. Eur Urol Focus. 2024 Jul; 10(4):641-647.Al-Faouri R, Sharkey C, Gershman B, Tsai LL, Wang Z, Olumi AF. Eur Urol Focus2024 Jul10(4):641-647http://www.ncbi.nlm.nih.gov/pubmed/34854747Zonal Growth Pattern of the Prostate Is Affected by Age and Body Mass Index. J Urol. 2022 04; 207(4):876-884.Sharkey C, Long X, Wang Z, Al-Faouri R, Gershman B, Tsai LL, Olumi AF. J Urol2022 04207(4):876-884Prostatic Hyperplasia39.237645400489795e-0012021-12-02T00:00:002024-04-12T00:00:00Prostate36.748307428258944e-0012021-12-02T00:00:002024-04-12T00:00:003-Oxo-5-alpha-Steroid 4-Dehydrogenase24.107943575169116e-0012023-10-27T00:00:002024-04-12T00:00:00Tumor Necrosis Factor-alpha13.730139382148606e-0012023-10-27T00:00:002023-10-27T00:00:00Multiparametric Magnetic Resonance Imaging11.791246227061188e-0012024-06-04T00:00:002024-06-04T00:00:00Organ Size21.749932569411148e-0012021-12-02T00:00:002023-10-27T00:00:00Estrogen Receptor alpha11.563235382164239e-0012024-04-12T00:00:002024-04-12T00:00:00Magnetic Resonance Imaging31.328898430235876e-0012021-12-02T00:00:002024-06-04T00:00:00Quality-Adjusted Life Years11.289713441893366e-0012024-06-04T00:00:002024-06-04T00:00:00Membrane Proteins21.263712088369418e-0012023-10-27T00:00:002024-04-12T00:00:00Prostate-Specific Antigen11.078504522052295e-0012024-06-04T00:00:002024-06-04T00:00:00Decision Support Techniques11.024826873256435e-0012024-06-04T00:00:002024-06-04T00:00:005-alpha Reductase Inhibitors28.873098636214050e-0022021-12-02T00:00:002024-04-12T00:00:00Epithelial Cells18.835440588907302e-0022024-04-12T00:00:002024-04-12T00:00:00Cost-Benefit Analysis18.416408153073872e-0022024-06-04T00:00:002024-06-04T00:00:00Early Detection of Cancer17.278294249263695e-0022024-06-04T00:00:002024-06-04T00:00:00Body Mass Index15.184427401675398e-0022021-12-02T00:00:002021-12-02T00:00:00Lower Urinary Tract Symptoms14.857943700019125e-0022024-04-12T00:00:002024-04-12T00:00:00Aging14.569288708176208e-0022021-12-02T00:00:002021-12-02T00:00:00Prostatic Neoplasms14.361293285846782e-0022024-06-04T00:00:002024-06-04T00:00:00Tomography, X-Ray Computed13.954737901038117e-0022023-10-27T00:00:002023-10-27T00:00:00Retrospective Studies23.208145512891411e-0022021-12-02T00:00:002023-10-27T00:00:00Aged32.940364082736317e-0022021-12-02T00:00:002024-06-04T00:00:00Middle Aged32.631818181247211e-0022021-12-02T00:00:002024-06-04T00:00:00Male42.404503102783162e-0022021-12-02T00:00:002024-06-04T00:00:00Biopsy12.324220480137664e-0022024-06-04T00:00:002024-06-04T00:00:00Mice, Knockout11.779629904677019e-0022024-04-12T00:00:002024-04-12T00:00:00Cell Proliferation11.748483573540760e-0022024-04-12T00:00:002024-04-12T00:00:00Mass Screening11.707643953822557e-0022024-06-04T00:00:002024-06-04T00:00:00Humans41.582802934888960e-0022021-12-02T00:00:002024-06-04T00:00:00Cell Differentiation11.524965149633207e-0022024-04-12T00:00:002024-04-12T00:00:00Disease Models, Animal11.338569277960664e-0022024-04-12T00:00:002024-04-12T00:00:00Mice17.844879063978134e-0032024-04-12T00:00:002024-04-12T00:00:00United States17.343603618929767e-0032024-06-04T00:00:002024-06-04T00:00:00Animals15.592434418075292e-0032024-04-12T00:00:002024-04-12T00:00:00Oludamilola Adeola Aladesanmi, M.D.OludamilolaAladesanmi

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyClinical Fellow in MedicineFellow or Post DocMaria Alejandra Alape Moya, M.D.MariaAlape Moya

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaClinical ResearchResearch Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41101834Inhalational Agents as Intensive Care Unit Sedatives. Crit Care Clin. 2025 Oct; 41(4):721-734.Alape Moya MA, O'Gara B. Crit Care Clin2025 Oct41(4):721-734Anesthetics, Inhalation16.658133158762689e-0012025-10-01T00:00:002025-10-01T00:00:00Hypnotics and Sedatives15.248184596167107e-0012025-10-01T00:00:002025-10-01T00:00:00Critical Care13.773944595951345e-0012025-10-01T00:00:002025-10-01T00:00:00Intensive Care Units13.621638407077561e-0012025-10-01T00:00:002025-10-01T00:00:00Respiration, Artificial11.065599103461451e-0012025-10-01T00:00:002025-10-01T00:00:00Humans11.041099196567859e-0022025-10-01T00:00:002025-10-01T00:00:00Adam S Albano, M.D.AdamAlbano

Fenway Community Health Center142 Berkley St7 Haviland StBoston, MA 02215617/927-6422

1BIDMCBeth Israel Deaconess Medical CenterMedicineFenwayInstructor in MedicineInstructorDuha Albeik, M.D.DuhaAlbeik

Beth Israel Deaconess Medical Center One Deaconess RdBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyResearch Fellow in RadiologyFellow or Post DocMahsa Alborzi Avanaki, M.D.MahsaAlborzi Avanaki

Beth Israel Deaconess Medical Center One Deaconess RdBoston, MA 02215617/754-2009

1BIDMCBeth Israel Deaconess Medical CenterRadiologyResearch Fellow in Radiology; Metastatic Spinal DiseaseFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=214791451http://www.ncbi.nlm.nih.gov/pubmed/40036250Introducing the Team Card: Enhancing governance for medical Artificial Intelligence (AI) systems in the age of complexity. PLOS Digit Health. 2025 Mar; 4(3):e0000495.Modise LM, Alborzi Avanaki M, Ameen S, Celi LA, Chen VXY, Cordes A, Elmore M, Fiske A, Gallifant J, Hayes M, Marcelo A, Matos J, Nakayama L, Ozoani E, Silverman BC, Comeau DS. PLOS Digit Health2025 Mar4(3):e0000495http://www.ncbi.nlm.nih.gov/pubmed/34025894Multi-organ infarction following percutaneous transhepatic esophageal variceal obliteration with glue injection: a case report. Radiol Case Rep. 2021 Jul; 16(7):1828-1832.Abrishami A, Alborzi Avanaki M, Khalili N, Taher M, Ghanaati H. Radiol Case Rep2021 Jul16(7):1828-1832Mary Alexandra Albrecht, M.D.MaryAlbrecht

Beth Israel Deaconess Med CtrInfectious Disease330 Brookline AveBoston, MA 02215617/632-076042.34022770000000-71.10585400000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineInfectious DiseaseAssociate Professor of MedicineAssociate Professorhttp://www.ncbi.nlm.nih.gov/pubmed/27419167Fatal Spontaneous Clostridium bifermentans Necrotizing Endometritis: A Case Report and Literature Review of the Pathogen. Open Forum Infect Dis. 2016 Apr; 3(2):ofw095.Hale A, Kirby JE, Albrecht M. Open Forum Infect Dis2016 Apr3(2):ofw095http://www.ncbi.nlm.nih.gov/pubmed/26730393Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report. Open Forum Infect Dis. 2016 Jan; 3(1):ofv185.Leahey PA, Tahan SR, Kasper EM, Albrecht M. Open Forum Infect Dis2016 Jan3(1):ofv185http://www.ncbi.nlm.nih.gov/pubmed/26494772Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men. J Infect Dis. 2016 Mar 01; 213(5):771-5.Scully E, Lockhart A, Huang L, Robles Y, Becerril C, Romero-Tejeda M, Albrecht MA, Palmer CD, Bosch RJ, Altfeld M, Kuritzkes DR, Lin NH. J Infect Dis2016 Mar 01213(5):771-5http://www.ncbi.nlm.nih.gov/pubmed/23503447Discordant associations between SLCO1B1 521T?C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. Ther Drug Monit. 2013 Apr; 35(2):209-16.Zhang X, Tierney C, Albrecht M, Demeter LM, Morse G, DiFrancesco R, Dykes C, Jiang H, Haas DW. Ther Drug Monit2013 Apr35(2):209-16http://www.ncbi.nlm.nih.gov/pubmed/22044856A randomized clinical trial evaluating therapeutic drug monitoring (TDM) for protease inhibitor-based regimens in antiretroviral-experienced HIV-infected individuals: week 48 results of the A5146 study. HIV Clin Trials. 2011 Jul-Aug; 12(4):201-14.Albrecht M, Mukherjee AL, Tierney C, Morse GD, Dykes C, Klingman KL, Demeter LM. HIV Clin Trials2011 Jul-Aug12(4):201-14http://www.ncbi.nlm.nih.gov/pubmed/20592644Quality assessment for therapeutic drug monitoring in AIDS Clinical Trials Group (ACTG 5146): a multicenter clinical trial. Ther Drug Monit. 2010 Aug; 32(4):458-66.DiFrancesco R, Rosenkranz S, Mukherjee AL, Demeter LM, Jiang H, DiCenzo R, Dykes C, Rinehart A, Albrecht M, Morse GD. Ther Drug Monit2010 Aug32(4):458-66http://www.ncbi.nlm.nih.gov/pubmed/20001856No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy. J Infect Dis. 2010 Jan 15; 201(2):293-6.Gandhi RT, Bosch RJ, Aga E, Albrecht M, Demeter LM, Dykes C, Bastow B, Para M, Lai J, Siliciano RF, Siliciano JD, Eron JJ. J Infect Dis2010 Jan 15201(2):293-6http://www.ncbi.nlm.nih.gov/pubmed/19114860A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviral-experienced, HIV-1-infected patients. AIDS. 2009 Jan 28; 23(3):357-68.Demeter LM, Jiang H, Mukherjee AL, Morse GD, DiFrancesco R, DiCenzo R, Dykes C, Sista P, Bacheler L, Klingman K, Rinehart A, Albrecht M. AIDS2009 Jan 2823(3):357-68http://www.ncbi.nlm.nih.gov/pubmed/18215983The design and implementation of A5146, a prospective trial assessing the utility of therapeutic drug monitoring using an inhibitory quotient in antiretroviral-experienced HIV-infected patients. HIV Clin Trials. 2008 Jan-Feb; 9(1):61-72.Demeter LM, Mukherjee AL, DiFrancesco R, Jiang H, DiCenzo R, Bastow B, Rinehart AR, Morse GD, Albrecht M. HIV Clin Trials2008 Jan-Feb9(1):61-72http://www.ncbi.nlm.nih.gov/pubmed/17278071Evidence of ongoing immune reconstitution in subjects with sustained viral suppression following 6 years of lopinavir-ritonavir treatment. Clin Infect Dis. 2007 Mar 01; 44(5):749-54.Landay A, da Silva BA, King MS, Albrecht M, Benson C, Eron J, Glesby M, Gulick R, Hicks C, Kessler H, Murphy R, Thompson M, White AC, Wolfe P, McMillan FI, Hanna GJ. Clin Infect Dis2007 Mar 0144(5):749-54http://www.ncbi.nlm.nih.gov/pubmed/17183628Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment. J Acquir Immune Defic Syndr. 2006 Dec 01; 43(4):433-5.Bosch RJ, Wang R, Vaida F, Lederman MM, Albrecht MA. J Acquir Immune Defic Syndr2006 Dec 0143(4):433-5http://www.ncbi.nlm.nih.gov/pubmed/15316338Genetic correlates of efavirenz hypersusceptibility. AIDS. 2004 Sep 03; 18(13):1781-5.Shulman NS, Bosch RJ, Mellors JW, Albrecht MA, Katzenstein DA. AIDS2004 Sep 0318(13):1781-5http://www.ncbi.nlm.nih.gov/pubmed/16215131Combination megestrol acetate, oxandrolone, and dietary advice restores weight in human immunodeficiency virus. Nutr Clin Pract. 2004 Aug; 19(4):395-402.Mwamburi DM, Gerrior J, Wilson IB, Chang H, Scully E, Saboori S, Miller L, Forfia J, Albrecht M, Wanke CA. Nutr Clin Pract2004 Aug19(4):395-402http://www.ncbi.nlm.nih.gov/pubmed/14999637Comparing megestrol acetate therapy with oxandrolone therapy for HIV-related weight loss: similar results in 2 months. Clin Infect Dis. 2004 Mar 15; 38(6):895-902.Mwamburi DM, Gerrior J, Wilson IB, Chang H, Scully E, Saboori S, Miller L, Forfia J, Albrecht M, Wanke CA. Clin Infect Dis2004 Mar 1538(6):895-902http://www.ncbi.nlm.nih.gov/pubmed/14571193Evaluation of cutpoints for phenotypic hypersusceptibility to efavirenz. AIDS. 2003 Nov 07; 17(16):2395-6.Bosch RJ, Downey GF, Katzenstein DA, Hellmann N, Bacheler L, Albrecht MA. AIDS2003 Nov 0717(16):2395-6http://www.ncbi.nlm.nih.gov/pubmed/14513420Assessing resistance costs of antiretroviral therapies via measures of future drug options. J Infect Dis. 2003 Oct 01; 188(7):1001-8.Jiang H, Deeks SG, Kuritzkes DR, Lallemant M, Katzenstein D, Albrecht M, DeGruttola V. J Infect Dis2003 Oct 01188(7):1001-8http://www.ncbi.nlm.nih.gov/pubmed/12898440Clinical impact of the M184V mutation on switching to didanosine or maintaining lamivudine treatment in nucleoside reverse-transcriptase inhibitor-experienced patients. J Infect Dis. 2003 Aug 15; 188(4):537-40.Winters MA, Bosch RJ, Albrecht MA, Katzenstein DA. J Infect Dis2003 Aug 15188(4):537-40http://www.ncbi.nlm.nih.gov/pubmed/12788996Successful cardiac transplantation in an HIV-1-infected patient with advanced disease. N Engl J Med. 2003 Jun 05; 348(23):2323-8.Calabrese LH, Albrecht M, Young J, McCarthy P, Haug M, Jarcho J, Zackin R. N Engl J Med2003 Jun 05348(23):2323-8http://www.ncbi.nlm.nih.gov/pubmed/12837969Advances in antiretroviral therapy. Top HIV Med. 2003 May-Jun; 11(3):97-127.Albrecht MA, Wilkin TJ, Coakley EP, Hammer SM. Top HIV Med2003 May-Jun11(3):97-127http://www.ncbi.nlm.nih.gov/pubmed/12660529Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs. AIDS. 2003 Apr 11; 17(6):821-30.Katzenstein DA, Bosch RJ, Hellmann N, Wang N, Bacheler L, Albrecht MA. AIDS2003 Apr 1117(6):821-30HIV Protease Inhibitors58.818851779290735e-0012008-01-01T00:00:002013-04-01T00:00:00Drug Monitoring45.088946119256612e-0012008-01-01T00:00:002011-07-01T00:00:00Anti-HIV Agents124.035400726533553e-0012003-04-11T00:00:002015-10-22T00:00:00HIV-1123.690985515750435e-0012003-04-11T00:00:002015-10-22T00:00:00Reverse Transcriptase Inhibitors63.430691407495622e-0012003-04-11T00:00:002006-12-01T00:00:00HIV Infections132.927330657962174e-0012003-04-11T00:00:002015-10-22T00:00:00HIV21.650616294637302e-0012003-05-01T00:00:002008-01-01T00:00:00Viral Load81.530701368124449e-0012003-04-11T00:00:002011-07-01T00:00:00Antiretroviral Therapy, Highly Active51.526884653053682e-0012003-05-01T00:00:002010-08-01T00:00:00Ritonavir21.390084495941433e-0012007-01-25T00:00:002013-04-01T00:00:00Acquired Immunodeficiency Syndrome31.263249635668867e-0012003-06-05T00:00:002013-04-01T00:00:00CD4 Lymphocyte Count41.200747311351837e-0012003-06-05T00:00:002011-07-01T00:00:00Bacterial Translocation11.154502909024295e-0012015-10-22T00:00:002015-10-22T00:00:00RNA, Viral61.054052814137272e-0012003-04-11T00:00:002009-01-28T00:00:00Drug Resistance, Viral41.029527673546036e-0012003-04-11T00:00:002009-01-28T00:00:00Chemokine CCL219.815912947880820e-0022015-10-22T00:00:002015-10-22T00:00:00Oxazines39.794146258618929e-0022003-04-11T00:00:002004-09-03T00:00:00Organic Anion Transporters19.313017948139306e-0022013-04-01T00:00:002013-04-01T00:00:00Linkage Disequilibrium17.040893009692878e-0022013-04-01T00:00:002013-04-01T00:00:00HIV Envelope Protein gp4116.772974021884232e-0022010-01-15T00:00:002010-01-15T00:00:00Virus Latency16.314752697321745e-0022010-01-15T00:00:002010-01-15T00:00:00Lamivudine25.887619930232149e-0022003-07-24T00:00:002007-01-25T00:00:00Megestrol Acetate15.363248290830724e-0022004-03-01T00:00:002004-03-01T00:00:00Oxandrolone15.299546575881498e-0022004-03-01T00:00:002004-03-01T00:00:00Pyrimidinones15.188187525239758e-0022007-01-25T00:00:002007-01-25T00:00:00Genetic Association Studies15.146256312065897e-0022013-04-01T00:00:002013-04-01T00:00:00Drug Resistance, Multiple, Viral15.066549836185505e-0022003-09-23T00:00:002003-09-23T00:00:00Didanosine15.008733360742317e-0022003-07-24T00:00:002003-07-24T00:00:00Drug Therapy, Combination34.723363686995285e-0022003-04-11T00:00:002010-01-15T00:00:00Drug Administration Schedule14.279627112751886e-0022009-01-28T00:00:002009-01-28T00:00:00Alkynes33.589718659111606e-0022003-04-11T00:00:002004-09-03T00:00:00Cyclopropanes33.423572484675063e-0022003-04-11T00:00:002004-09-03T00:00:00Benzoxazines33.405878910396472e-0022003-04-11T00:00:002004-09-03T00:00:00Peptide Fragments13.262795131183909e-0022010-01-15T00:00:002010-01-15T00:00:00CD4-Positive T-Lymphocytes13.253731958374458e-0022010-01-15T00:00:002010-01-15T00:00:00Antiviral Agents13.236910702916267e-0022010-01-15T00:00:002010-01-15T00:00:00Aging12.990957728001645e-0022015-10-22T00:00:002015-10-22T00:00:00Male112.462463896704071e-0022003-04-11T00:00:002015-10-22T00:00:00Body Weight12.452544852935472e-0022004-03-01T00:00:002004-03-01T00:00:00Liver-Specific Organic Anion Transporter 112.436910609948975e-0022013-04-01T00:00:002013-04-01T00:00:00Humans172.410191435486462e-0022003-04-11T00:00:002015-10-22T00:00:00Adult82.398245676257789e-0022003-06-05T00:00:002015-10-22T00:00:00Treatment Outcome32.386303120943924e-0022006-12-01T00:00:002010-08-01T00:00:00HIV Reverse Transcriptase22.350505539026888e-0022003-04-11T00:00:002003-11-07T00:00:00Weight Loss12.294918298092269e-0022004-03-01T00:00:002004-03-01T00:00:00Follow-Up Studies22.276327409700727e-0022007-01-25T00:00:002011-07-01T00:00:00Research Design12.248530519952962e-0022008-01-01T00:00:002008-01-01T00:00:00Female92.063182274315923e-0022003-04-11T00:00:002013-04-01T00:00:00Cardiomyopathies12.031399006585929e-0022003-06-05T00:00:002003-06-05T00:00:00Enfuvirtide12.009731096827734e-0022010-01-15T00:00:002010-01-15T00:00:00Middle Aged52.005021505487091e-0022007-01-25T00:00:002015-10-22T00:00:00Heart Transplantation11.877610150279796e-0022003-06-05T00:00:002003-06-05T00:00:00Calibration11.706379307336928e-0022010-08-01T00:00:002010-08-01T00:00:00Quality Control11.670674641034573e-0022010-08-01T00:00:002010-08-01T00:00:00CD4-CD8 Ratio11.616719438554677e-0022007-01-25T00:00:002007-01-25T00:00:00Stavudine11.612671336731097e-0022007-01-25T00:00:002007-01-25T00:00:00Treatment Failure21.606860205431057e-0022003-04-11T00:00:002003-09-23T00:00:00Clinical Trials as Topic11.584086474875613e-0022003-05-01T00:00:002003-05-01T00:00:00Laboratories11.581934363499330e-0022010-08-01T00:00:002010-08-01T00:00:00Genotype21.575056735886616e-0022004-09-03T00:00:002015-10-22T00:00:00Lopinavir11.542574357684539e-0022007-01-25T00:00:002007-01-25T00:00:00Virus Replication21.496391812235990e-0022003-04-11T00:00:002004-09-03T00:00:00Specimen Handling11.427648557781137e-0022010-08-01T00:00:002010-08-01T00:00:00Lymphocyte Activation11.362170362038720e-0022015-10-22T00:00:002015-10-22T00:00:00Proportional Hazards Models31.357607812518330e-0022003-04-11T00:00:002003-11-07T00:00:00Clinical Trials, Phase II as Topic11.286891508794820e-0022007-01-25T00:00:002007-01-25T00:00:00Immunity, Innate11.200241519372646e-0022015-10-22T00:00:002015-10-22T00:00:00Cyclosporine11.037324762697295e-0022003-06-05T00:00:002003-06-05T00:00:00Biomarkers29.718271407407702e-0032007-01-25T00:00:002015-10-22T00:00:00AIDS-Related Opportunistic Infections19.663083309262814e-0032003-06-05T00:00:002003-06-05T00:00:00Erythrocyte Transfusion18.649808417694143e-0032003-06-05T00:00:002003-06-05T00:00:00T-Lymphocytes18.354105933429674e-0032015-10-22T00:00:002015-10-22T00:00:00Multicenter Studies as Topic18.351604151105630e-0032003-09-23T00:00:002003-09-23T00:00:00Androgens17.846512076870794e-0032004-03-01T00:00:002004-03-01T00:00:00Microbial Sensitivity Tests17.518179503015248e-0032003-04-11T00:00:002003-04-11T00:00:00Anti-Infective Agents17.334077088624214e-0032003-06-05T00:00:002003-06-05T00:00:00Phenotype27.322277497929470e-0032003-04-11T00:00:002004-09-03T00:00:00Inflammation17.064557249977385e-0032015-10-22T00:00:002015-10-22T00:00:00Weight Gain16.404535121471510e-0032004-03-01T00:00:002004-03-01T00:00:00Immunosuppressive Agents14.963362361938759e-0032003-06-05T00:00:002003-06-05T00:00:00Graft Rejection14.793302382885570e-0032003-06-05T00:00:002003-06-05T00:00:00Mutation24.644286004276086e-0032003-07-24T00:00:002004-09-03T00:00:00Models, Statistical14.643107866313605e-0032003-09-23T00:00:002003-09-23T00:00:00Risk Factors23.839731219653125e-0032003-04-11T00:00:002004-09-03T00:00:00Randomized Controlled Trials as Topic13.723605254276516e-0032003-09-23T00:00:002003-09-23T00:00:00Cohort Studies13.253857189481279e-0032007-01-25T00:00:002007-01-25T00:00:00Postoperative Complications12.468074279099810e-0032003-06-05T00:00:002003-06-05T00:00:00Retrospective Studies11.583710175100856e-0032003-04-11T00:00:002003-04-11T00:00:00Nawaf Alfuraih, M.B.,B.S.NawafAlfuraih

Beth Israel Deaconess Medical CenterBaker 4th Floor330 Brookline AveBoston, MA 02215617/667-8800

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyClinical Fellow in MedicineFellow or Post DocHassan Adam Alhassan, M.B.,Ch.B.HassanAlhassan

Beth Israel Deaconess Medical CenterDivision: Cardiology330 Brookline AveBoston, MA 02215617/667-8800

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyClinical Fellow in MedicineFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=215024241http://www.ncbi.nlm.nih.gov/pubmed/41556237The Pause at the Table: A Fellow's Perspective on Uncertainty in the EP Lab. J Cardiovasc Electrophysiol. 2026 Feb; 37(2):231-232.Alhassan HA. J Cardiovasc Electrophysiol2026 Feb37(2):231-232http://www.ncbi.nlm.nih.gov/pubmed/41534380Association of Sleep Quality With Arterial Stiffness Measures in a Community-Based Sample. JACC Adv. 2026 Feb; 5(2):102535.Alhassan HA, Heckman E, Jha M, Vasan RS, Mitchell GF, Thomas RJ, Tsao CW. JACC Adv2026 Feb5(2):102535http://www.ncbi.nlm.nih.gov/pubmed/41589784PVC Location and Heart Failure: Signal, Surrogate, or Substrate? JACC Clin Electrophysiol. 2026 Jan; 12(1):181.Alhassan HA. JACC Clin Electrophysiol2026 Jan12(1):181http://www.ncbi.nlm.nih.gov/pubmed/41532942Private Equity in Cardiology: A Crossroads for a New Generation of Physicians. J Am Coll Cardiol. 2025 Dec 25.Alhassan HA. J Am Coll Cardiol2025 Dec 25http://www.ncbi.nlm.nih.gov/pubmed/41118128Multivariable Prediction Models for Atrial Fibrillation after Cardiac Surgery: A Systematic Review and Critical Appraisal. Anesthesiology. 2025 Dec 01; 143(6):1643-1655.Fields KG, Milner GDM, Ma J, Dhiman P, Redfern OC, Karamnov S, He J, Gerry S, Alhassan H, Providencia R, Lip GYH, Bedford JP, Clifton DA, O'Brien B, Watkinson PJ, Collins GS, Muehlschlegel JD. Anesthesiology2025 Dec 01143(6):1643-1655http://www.ncbi.nlm.nih.gov/pubmed/40995906The efficacy of combined povidone-iodine 1% and dexamethasone 0.08% prepared eye drops in treating post-viral corneal subepithelial infiltrates. Indian J Ophthalmol. 2025 Oct 01; 73(10):1477-1481.Alkassasbeh MK, Alzweimel FH, Alshdaifat MA, Alkilany IM, Alhassan HA, Khlaifat AK, Nawaiseh MB. Indian J Ophthalmol2025 Oct 0173(10):1477-1481http://www.ncbi.nlm.nih.gov/pubmed/40672504SEX DIFFERENCES IN PHARMACOLOGIC OPTIMAL MEDICAL THERAPY FOR ISCHEMIC HEART DISEASE, 2010-2020: AN OBSERVATIONAL STUDY. medRxiv. 2025 Jul 10.Alhassan HA, Mann H, Chiu L, Malik B, Countouris M, Johnson AE. medRxiv2025 Jul 10http://www.ncbi.nlm.nih.gov/pubmed/37860878Comparison of Atherosclerotic Cardiovascular Risk Factors and Cardiometabolic Profiles Between Current and Never Users of Marijuana. Circ Cardiovasc Qual Outcomes. 2023 11; 16(11):e009609.Alhassan HA, Akunor H, Howard A, Donohue J, Kainat A, Onyeaka HK, Aiyer A. Circ Cardiovasc Qual Outcomes2023 1116(11):e009609http://www.ncbi.nlm.nih.gov/pubmed/37449569Safety of Catheter Ablation Therapy for Atrial Fibrillation in Cardiac Amyloidosis. J Am Heart Assoc. 2023 07 18; 12(14):e029339.Alhassan HA, Kainat A, Donohue J, Baumgartner SJ, Akunor H, Saba S, Jain S, Soman P. J Am Heart Assoc2023 07 1812(14):e029339http://www.ncbi.nlm.nih.gov/pubmed/37452803Prevalence and Trends of Comorbid Depression and Heart Failure in the United States, 2005-2020. JACC Heart Fail. 2023 08; 11(8 Pt 1):1024-1026.Alhassan HA, Akunor H, Atarere J, Onyeaka HK, Donohue J, Aryan A, Hickey G, Rollman BL. JACC Heart Fail2023 0811(8 Pt 1):1024-1026http://www.ncbi.nlm.nih.gov/pubmed/36914189Multivariable prediction models for atrial fibrillation after cardiac surgery: a systematic review protocol. BMJ Open. 2023 03 13; 13(3):e067260.Fields KG, Ma J, Petrinic T, Alhassan H, Eze A, Reddy A, Hedayat M, Providencia R, Lip GYH, Bedford JP, Clifton DA, Redfern OC, O'Brien B, Watkinson PJ, Collins GS, Muehlschlegel JD. BMJ Open2023 03 1313(3):e067260http://www.ncbi.nlm.nih.gov/pubmed/35142834Association of Primary Care Physicians Per Capita With COVID-19 Vaccination Rates Among US Counties. JAMA Netw Open. 2022 02 01; 5(2):e2147920.Lo CH, Chiu L, Qian A, Khan MZ, Alhassan HA, Duval AJ, Chan AT. JAMA Netw Open2022 02 015(2):e2147920http://www.ncbi.nlm.nih.gov/pubmed/32766451The Analgesic Effect of Transcranial Direct Current Stimulation (tDCS) combined with Physical Therapy on Common Musculoskeletal Conditions: A Systematic Review and Meta-Analysis. Princ Pract Clin Res. 2020 Jan-Apr; 6(1):23-26.Teixeira PEP, Alawdah L, Alhassan HAA, Guidetti M, Priori A, Papatheodorou S, Fregni F. Princ Pract Clin Res2020 Jan-Apr6(1):23-26Cannabis15.134681237747337e-0012023-10-20T00:00:002023-10-20T00:00:00Cardiomyopathy, Dilated15.080114781608318e-0012023-07-14T00:00:002023-07-14T00:00:00Amyloidosis14.616274791733960e-0012023-07-14T00:00:002023-07-14T00:00:00Atrial Fibrillation33.303226127090519e-0012023-03-13T00:00:002025-10-21T00:00:00Cardiomyopathies13.274383187321157e-0012023-07-14T00:00:002023-07-14T00:00:00Catheter Ablation13.217240785227002e-0012023-07-14T00:00:002023-07-14T00:00:00Atherosclerosis12.683715434517786e-0012023-10-20T00:00:002023-10-20T00:00:00Povidone-Iodine12.297447735895047e-0012025-09-25T00:00:002025-09-25T00:00:00Eye Infections, Viral12.215171244599780e-0012025-09-25T00:00:002025-09-25T00:00:00Epithelium, Corneal11.857565618498733e-0012025-09-25T00:00:002025-09-25T00:00:00Vaccination Coverage11.579931569395472e-0012022-02-01T00:00:002022-02-01T00:00:00Heart Failure11.477190927180712e-0012023-07-12T00:00:002023-07-12T00:00:00Cardiac Surgical Procedures21.410891757417244e-0012023-03-13T00:00:002025-10-21T00:00:00Heart Disease Risk Factors11.391496453135681e-0012023-10-20T00:00:002023-10-20T00:00:00Dexamethasone11.362039696036268e-0012025-09-25T00:00:002025-09-25T00:00:00Cardiovascular Diseases11.328532791794667e-0012023-10-20T00:00:002023-10-20T00:00:00Nutrition Surveys11.204263306675442e-0012023-10-20T00:00:002023-10-20T00:00:00Physicians, Primary Care11.127503051079798e-0012022-02-01T00:00:002022-02-01T00:00:00Comorbidity17.270738653829653e-0022023-07-12T00:00:002023-07-12T00:00:00COVID-19 Vaccines16.730184355921408e-0022022-02-01T00:00:002022-02-01T00:00:00Risk Factors26.005866254470537e-0022023-07-12T00:00:002023-10-20T00:00:00Prevalence15.959532154571876e-0022023-07-12T00:00:002023-07-12T00:00:00Cross-Sectional Studies25.485844515558425e-0022022-02-01T00:00:002023-10-20T00:00:00Ophthalmic Solutions15.247085681380365e-0022025-09-25T00:00:002025-09-25T00:00:00Anti-Infective Agents, Local14.904845424835182e-0022025-09-25T00:00:002025-09-25T00:00:00Depression14.837855025097407e-0022023-07-12T00:00:002023-07-12T00:00:00Postoperative Complications14.656922757538982e-0022025-10-21T00:00:002025-10-21T00:00:00Review Literature as Topic14.235876236530344e-0022023-03-13T00:00:002023-03-13T00:00:00Systematic Reviews as Topic14.070102219881058e-0022023-03-13T00:00:002023-03-13T00:00:00Treatment Outcome23.924538635653467e-0022023-07-14T00:00:002025-09-25T00:00:00Humans73.635888132499696e-0022022-02-01T00:00:002025-10-21T00:00:00United States23.384661613496214e-0022022-02-01T00:00:002023-07-12T00:00:00Glucocorticoids12.953561329756066e-0022025-09-25T00:00:002025-09-25T00:00:00Drug Therapy, Combination12.892041507510681e-0022025-09-25T00:00:002025-09-25T00:00:00Bias12.873394320156162e-0022023-03-13T00:00:002023-03-13T00:00:00Visual Acuity12.663587289708732e-0022025-09-25T00:00:002025-09-25T00:00:00Dose-Response Relationship, Drug12.545853783724804e-0022025-09-25T00:00:002025-09-25T00:00:00Adult22.283891645742904e-0022023-10-20T00:00:002025-09-25T00:00:00Male32.083360254089589e-0022022-02-01T00:00:002025-09-25T00:00:00Female31.971850526764435e-0022022-02-01T00:00:002025-09-25T00:00:00Predictive Value of Tests11.846444530601553e-0022025-10-21T00:00:002025-10-21T00:00:00Reproducibility of Results11.366532388517099e-0022023-03-13T00:00:002023-03-13T00:00:00Risk Assessment11.303174030599614e-0022025-10-21T00:00:002025-10-21T00:00:00Follow-Up Studies11.289525040920830e-0022025-09-25T00:00:002025-09-25T00:00:00Prospective Studies11.037437858864643e-0022025-09-25T00:00:002025-09-25T00:00:00SARS-CoV-219.793434916865044e-0032022-02-01T00:00:002022-02-01T00:00:00Young Adult18.756871649065615e-0032025-09-25T00:00:002025-09-25T00:00:00COVID-1915.523306809305602e-0032022-02-01T00:00:002022-02-01T00:00:00Middle Aged15.076747844149872e-0032025-09-25T00:00:002025-09-25T00:00:00Hamza Ali, M.B.,B.S.HamzaAli

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/754-2523

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=186053074King Edward Medical UniversityLahore MBBS04/2021Rahmat Ali, M.B.,B.S.RahmatAli

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyResearch Fellow in MedicineFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=306987500http://www.ncbi.nlm.nih.gov/pubmed/41696665Nonadherence to Antiviral Therapy Leading to Severe Hepatic Decompensation in a Patient With Chronic Hepatitis B. ACG Case Rep J. 2026 Feb; 13(2):e01999.Ahmad S, Paracha S, Ali R, Akbar SMA, Asif MA, Saeed MO, Bai R, Afzal HMT, Shah SB, Lau DTY. ACG Case Rep J2026 Feb13(2):e01999http://www.ncbi.nlm.nih.gov/pubmed/40928014Letter to the Editor: Assessing HCC risk in HBV indeterminate phase. Hepatology. 2026 Jan 01; 83(1):E15-E16.Saeed MO, Paracha S, Ali R, Ali Akbar SM, Tousif Afzal HM. Hepatology2026 Jan 0183(1):E15-E16Sadique Ali, M.B.,B.S.SadiqueAli

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post DocKonstantinos Aliazis, Ph.D.KonstantinosAliazis

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineHematology/OncologyResearch Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/40514448The tumor microenvironment's role in the response to immune checkpoint blockade. Nat Cancer. 2025 Jun; 6(6):924-937.Aliazis K, Christofides A, Shah R, Yeo YY, Jiang S, Charest A, Boussiotis VA. Nat Cancer2025 Jun6(6):924-937http://www.ncbi.nlm.nih.gov/pubmed/39044285Emergency myelopoiesis in solid cancers. Br J Haematol. 2024 Sep; 205(3):798-811.Aliazis K, Yenyuwadee S, Phikulsod P, Boussiotis VA. Br J Haematol2024 Sep205(3):798-811http://www.ncbi.nlm.nih.gov/pubmed/38232704A four-cell pathway orchestrated by Flt3-L-dependent cDCs controls anti-tumor responses. Cell Rep Med. 2024 01 16; 5(1):101378.Aliazis K, Boussiotis VA. Cell Rep Med2024 01 165(1):101378http://www.ncbi.nlm.nih.gov/pubmed/37342323Immune-related adverse effects of checkpoint immunotherapy and implications for the treatment of patients with cancer and autoimmune diseases. Front Immunol. 2023; 14:1197364.Ibis B, Aliazis K, Cao C, Yenyuwadee S, Boussiotis VA. Front Immunol202314:1197364http://www.ncbi.nlm.nih.gov/pubmed/36881002Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma. Cancer Immunol Res. 2023 05 03; 11(5):629-645.Yeo AT, Shah R, Aliazis K, Pal R, Xu T, Zhang P, Rawal S, Rose CM, Varn FS, Appleman VA, Yoon J, Varma H, Gygi SP, Verhaak RGW, Boussiotis VA, Charest A. Cancer Immunol Res2023 05 0311(5):629-645http://www.ncbi.nlm.nih.gov/pubmed/36581713SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses. 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Bone2022 05158:116354http://www.ncbi.nlm.nih.gov/pubmed/34548339The human liver microenvironment shapes the homing and function of CD4+ T-cell populations. Gut. 2022 07; 71(7):1399-1411.Wiggins BG, Pallett LJ, Li X, Davies SP, Amin OE, Gill US, Kucykowicz S, Patel AM, Aliazis K, Liu YS, Reynolds GM, Davidson BR, Gander A, Luong TV, Hirschfield GM, Kennedy PTF, Huang Y, Maini MK, Stamataki Z. Gut2022 0771(7):1399-1411http://www.ncbi.nlm.nih.gov/pubmed/34071712The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence. Viruses. 2021 05 28; 13(6).Abdullah N, Ahemad N, Aliazis K, Khairat JE, Lee TC, Abdul Ahmad SA, Adnan NAA, Macha NO, Hassan SS. Viruses2021 05 2813(6)http://www.ncbi.nlm.nih.gov/pubmed/28349484In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma. 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Methods Mol Biol20171591:195-214Myelopoiesis18.015990566124288e-0012024-07-23T00:00:002024-07-23T00:00:00Tumor Microenvironment55.360745169433162e-0012022-08-18T00:00:002025-06-13T00:00:00Killer Cells, Natural14.278842185117187e-0012024-01-16T00:00:002024-01-16T00:00:00Neoplasms64.105432457296334e-0012022-08-18T00:00:002025-06-13T00:00:00Immune Checkpoint Inhibitors13.406454894450665e-0012025-06-13T00:00:002025-06-13T00:00:00Alphavirus11.763457364518289e-0012021-05-28T00:00:002021-05-28T00:00:00Myeloid-Derived Suppressor Cells11.711892591537458e-0012023-05-03T00:00:002023-05-03T00:00:00Adaptive Immunity11.588799151736635e-0012025-06-13T00:00:002025-06-13T00:00:00Viral Nonstructural Proteins11.527595473732005e-0012021-05-28T00:00:002021-05-28T00:00:00Granulocyte-Macrophage Colony-Stimulating Factor11.504712391380747e-0012022-12-29T00:00:002022-12-29T00:00:00Parenchymal Tissue11.271480964835946e-0012017-01-01T00:00:002017-01-01T00:00:00Immunotherapy41.164242278756443e-0012022-08-18T00:00:002025-06-13T00:00:00Liver29.944596860017621e-0022017-01-01T00:00:002021-09-21T00:00:00Endometriosis19.857907217244251e-0022022-02-09T00:00:002022-02-09T00:00:00Lymphocyte Activation19.642803600788819e-0022024-01-16T00:00:002024-01-16T00:00:00Evolution, Molecular19.617743510590884e-0022021-05-28T00:00:002021-05-28T00:00:00T-Lymphocytes29.544454820146663e-0022017-01-01T00:00:002024-01-16T00:00:00Drug-Related Side Effects and Adverse Reactions19.495004525552452e-0022023-06-05T00:00:002023-06-05T00:00:00Host-Pathogen Interactions19.401485052406206e-0022021-05-28T00:00:002021-05-28T00:00:00Antineoplastic Agents, Immunological18.891421796232618e-0022023-06-05T00:00:002023-06-05T00:00:00Hematopoietic Stem Cells18.869547342640585e-0022024-07-23T00:00:002024-07-23T00:00:00Autoimmune Diseases18.419324416669485e-0022023-06-05T00:00:002023-06-05T00:00:00CD4-Positive T-Lymphocytes17.312356145005253e-0022021-09-21T00:00:002021-09-21T00:00:00Glioblastoma16.761006418917388e-0022023-05-03T00:00:002023-05-03T00:00:00Animals56.200018124161283e-0022021-05-28T00:00:002025-06-13T00:00:00MicroRNAs15.823628235773375e-0022022-02-09T00:00:002022-02-09T00:00:00Cell Movement15.473973584030110e-0022017-01-01T00:00:002017-01-01T00:00:00Protein Tyrosine Phosphatase, Non-Receptor Type 614.772980908535721e-0022022-12-29T00:00:002022-12-29T00:00:00Programmed Cell Death 1 Receptor24.478818993065173e-0022022-12-29T00:00:002023-05-03T00:00:00Protein Tyrosine Phosphatase, Non-Receptor Type 1114.462580770810342e-0022022-12-29T00:00:002022-12-29T00:00:00Monitoring, Immunologic14.331855613720590e-0022021-09-21T00:00:002021-09-21T00:00:00Brain Neoplasms14.308291291043075e-0022023-05-03T00:00:002023-05-03T00:00:00Humans94.067842476796110e-0022017-01-01T00:00:002025-06-13T00:00:00Menstrual Cycle13.506050688825090e-0022022-02-09T00:00:002022-02-09T00:00:00Bone Remodeling13.500558353197296e-0022022-02-09T00:00:002022-02-09T00:00:00CTLA-4 Antigen13.390253628188066e-0022023-05-03T00:00:002023-05-03T00:00:00Myeloid Cells13.254829114734312e-0022022-12-29T00:00:002022-12-29T00:00:00Kupffer Cells13.075102253844905e-0022017-01-01T00:00:002017-01-01T00:00:00Hepatic Stellate Cells12.982896688292372e-0022017-01-01T00:00:002017-01-01T00:00:00Cellular Microenvironment12.885302439275389e-0022017-01-01T00:00:002017-01-01T00:00:00Myofibroblasts12.756568198001966e-0022017-01-01T00:00:002017-01-01T00:00:00Immunologic Memory12.690830426222758e-0022021-09-21T00:00:002021-09-21T00:00:00Endothelium12.650903202934196e-0022017-01-01T00:00:002017-01-01T00:00:00Virus Replication12.501590174864965e-0022021-05-28T00:00:002021-05-28T00:00:00Immunologic Factors12.471540676647617e-0022022-08-18T00:00:002022-08-18T00:00:00Binding Sites12.372257239457606e-0022021-05-28T00:00:002021-05-28T00:00:00Mice32.095076326817093e-0022021-05-28T00:00:002023-05-03T00:00:00Signal Transduction21.884115312515866e-0022022-08-18T00:00:002022-12-29T00:00:00Bone Density11.871437693020092e-0022022-02-09T00:00:002022-02-09T00:00:00CD8-Positive T-Lymphocytes11.654798369648110e-0022021-09-21T00:00:002021-09-21T00:00:00Cell Line11.652187155199572e-0022021-05-28T00:00:002021-05-28T00:00:00Cytokines11.545844063977629e-0022021-09-21T00:00:002021-09-21T00:00:00Antibodies, Monoclonal11.510735239320078e-0022023-06-05T00:00:002023-06-05T00:00:00Cell Line, Tumor11.503994191312245e-0022023-05-03T00:00:002023-05-03T00:00:00Cell Differentiation11.394837721824835e-0022022-12-29T00:00:002022-12-29T00:00:00Epithelial Cells11.333836042627309e-0022017-01-01T00:00:002017-01-01T00:00:00Biomarkers19.731948044465203e-0032022-02-09T00:00:002022-02-09T00:00:00Mutation18.792147659543080e-0032023-05-03T00:00:002023-05-03T00:00:00Prospective Studies18.069400941228683e-0032022-02-09T00:00:002022-02-09T00:00:00Female12.907534845188266e-0032022-02-09T00:00:002022-02-09T00:00:00Sanam Alilou, M.D.SanamAlilou

Beth Israel Deaconess Medical CenterDivision: Cardiology330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyResearch Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41389862Adjunctive superior vena cava isolation to pulmonary vein isolation in atrial fibrillation ablation: A systematic review and meta-analysis of randomized trials. Heart Rhythm. 2025 Dec 11.Alilou S, Babaei M, Fallahtafti P, Castro-Urda V, Oraii A, Rashedi S, Di Biase L. Heart Rhythm2025 Dec 11http://www.ncbi.nlm.nih.gov/pubmed/41354926Improving CAR T cell therapy against malignancies through gene knock-down/out strategies: a systematic review. Cancer Cell Int. 2025 Dec 07; 26(1):8.Karimi A, Kazemi-Harikandei SZ, Alilou S, Salabat D, Pourfaraji SM, Shirmard FO, Seighali N, Maleki S, Akbari B, Noorbakhsh F, Hadjati J, Mirzaei HR. Cancer Cell Int2025 Dec 0726(1):8http://www.ncbi.nlm.nih.gov/pubmed/40877612The role of glucagon-like peptide-1 receptor agonists in weight regain treatment or prevention after bariatric surgery: a systematic review and meta-analysis. Eat Weight Disord. 2025 Aug 28; 30(1):70.Mousavi A, Shojaei S, Azarboo A, Bahri RA, Mohammadi S, Alilou S, Yousefifar S, Maleki S, Radkhah H. Eat Weight Disord2025 Aug 2830(1):70http://www.ncbi.nlm.nih.gov/pubmed/40551274Ischemic modified albumin and thiol levels in Coronavirus disease 19: a systematic review and meta-analysis. Diagn Progn Res. 2025 Jun 23; 9(1):13.Mousavi A, Shojaei S, Parhizkar P, Bahri RA, Alilou S, Radkhah H. Diagn Progn Res2025 Jun 239(1):13http://www.ncbi.nlm.nih.gov/pubmed/40108619Intraosseous versus intravenous vascular access in out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2025 Mar 19; 29(1):124.Alilou S, Moskowitz A, Rashedi S. Crit Care2025 Mar 1929(1):124http://www.ncbi.nlm.nih.gov/pubmed/40083673A Systematic Review of Vascular Injuries: A Review of Petechiae, Purpura, and Ecchymosis in Critical Situations Following COVID-19 Vaccination. Health Sci Rep. 2025 Mar; 8(3):e70503.Kalantari Y, Mirahmadi SMS, Alilou S, Sadeghi S, Aryanian Z, Jafarzadeh A, Goodarzi A. Health Sci Rep2025 Mar8(3):e70503http://www.ncbi.nlm.nih.gov/pubmed/38676847Periprocedural Changes of Serum Biomarkers in Predicting Complications Following Bariatric Surgery for Obesity: Systematic Review and Meta-analysis. Obes Surg. 2024 Jun; 34(6):2198-2215.AziziKia H, Shojaei S, Mousavi A, Salabat D, Shaker F, Dolama RH, Radkhah H, Alilou S. Obes Surg2024 Jun34(6):2198-2215http://www.ncbi.nlm.nih.gov/pubmed/37849915Insights into the Role of Galectin-3 as a Diagnostic and Prognostic Biomarker of Atrial Fibrillation. Dis Markers. 2023; 2023:2097012.Mohtasham Kia Y, Cannavo A, Bahiraie P, Alilou S, Saeedian B, Babajani N, Ghondaghsaz E, Khalaji A, Behnoush AH. Dis Markers20232023:2097012http://www.ncbi.nlm.nih.gov/pubmed/37542221The utility of syndecan-1 circulating levels as a biomarker in patients with previous or active COVID-19: a systematic review and meta-analysis. BMC Infect Dis. 2023 Aug 04; 23(1):510.Ghondaghsaz E, Khalaji A, Norouzi M, Fraser DD, Alilou S, Behnoush AH. BMC Infect Dis2023 Aug 0423(1):510http://www.ncbi.nlm.nih.gov/pubmed/37491177Radiological Findings as Predictors of COVID-19 Lung Sequelae: A Systematic Review and Meta-analysis. Acad Radiol. 2023 12; 30(12):3076-3085.Alilou S, Zangiabadian M, Pouramini A, Jaberinezhad M, Shobeiri P, Ghozy S, Haseli S, Beizavi Z. Acad Radiol2023 1230(12):3076-3085http://www.ncbi.nlm.nih.gov/pubmed/37259934The Effectiveness of Face Masks in Preventing COVID-19 Transmission: A Systematic Review. Infect Disord Drug Targets. 2023 Jun 01.SeyedAlinaghi S, Karimi A, Afsahi AM, Mirzapour P, Varshochi S, Mojdeganlou H, Mojdeganlou P, Razi A, Alilou S, Dashti M, Ghasemzadeh A, Saeidi S, Mehraeen E, Dadras O. Infect Disord Drug Targets2023 Jun 01http://www.ncbi.nlm.nih.gov/pubmed/37158917Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2023 May 08; 22(1):61.Khalaji A, Behnoush AH, Alilou S, Rezaee M, Peiman S, Sahebkar A. Lipids Health Dis2023 May 0822(1):61http://www.ncbi.nlm.nih.gov/pubmed/36947499Circulating long non-coding RNAs as novel diagnostic biomarkers for Alzheimer's disease (AD): A systematic review and meta-analysis. PLoS One. 2023; 18(3):e0281784.Shobeiri P, Alilou S, Jaberinezhad M, Zare F, Karimi N, Maleki S, Teixeira AL, Perry G, Rezaei N. PLoS One202318(3):e0281784http://www.ncbi.nlm.nih.gov/pubmed/36515930Relationship Between Preprocedural Lipid Levels and Periprocedural Myocardial Injury in Patients Undergoing Elective Percutaneous Coronary Intervention. Tex Heart Inst J. 2022 11 01; 49(6).Maadani M, Sarraf NS, Alilou S, Aeinfar K, Sadeghipour P, Zahedmehr A, Fathollahi MS, Hashemi Ghadi SI, Zavarehee A, Zolfaghari M, Zolfaghari R. Tex Heart Inst J2022 11 0149(6)http://www.ncbi.nlm.nih.gov/pubmed/36273121A systematic review and meta-analysis of the epidemiological characteristics of COVID-19 in children. BMC Pediatr. 2022 10 22; 22(1):613.Vosoughi F, Makuku R, Tantuoyir MM, Yousefi F, Shobeiri P, Karimi A, Alilou S, LaPorte R, Tilves C, Nabian MH, Yekaninejad MS. BMC Pediatr2022 10 2222(1):613http://www.ncbi.nlm.nih.gov/pubmed/35534886A systematic review on COVID-19 vaccination and cosmetic filler reactions: A focus on case studies and original articles. J Cosmet Dermatol. 2022 Jul; 21(7).Kalantari Y, Aryanian Z, Mirahmadi SM, Alilou S, Hatami P, Goodarzi A. J Cosmet Dermatol2022 Jul21(7)http://www.ncbi.nlm.nih.gov/pubmed/35318872Public acceptability of COVID-19 vaccines and its predictors in Middle ?Eastern/North African (MENA) countries: a systematic review?. Hum Vaccin Immunother. 2022 11 30; 18(5):2043719.Dadras O, SeyedAlinaghi S, Karimi A, Shamsabadi A, Mahdiabadi S, Mohammadi P, Amiri A, Shojaei A, Pashaei Z, Mirzapour P, Qaderi K, MohsseniPour M, Alilou S, Mehraeen E, Jahanfar S. Hum Vaccin Immunother2022 11 3018(5):2043719http://www.ncbi.nlm.nih.gov/pubmed/35252593Mucormycosis infection in patients with COVID-19: A systematic review. Health Sci Rep. 2022 Mar; 5(2):e529.SeyedAlinaghi S, Karimi A, Barzegary A, Pashaei Z, Afsahi AM, Alilou S, Janfaza N, Shojaei A, Afroughi F, Mohammadi P, Soleimani Y, Nazarian N, Amiri A, Tantuoyir MM, Oliaei S, Mehraeen E, Dadras O. Health Sci Rep2022 Mar5(2):e529http://www.ncbi.nlm.nih.gov/pubmed/35224217Impact of COVID-19 pandemic on routine vaccination coverage of children and adolescents: A systematic review. Health Sci Rep. 2022 Mar; 5(2):e00516.SeyedAlinaghi S, Karimi A, Mojdeganlou H, Alilou S, Mirghaderi SP, Noori T, Shamsabadi A, Dadras O, Vahedi F, Mohammadi P, Shojaei A, Mahdiabadi S, Janfaza N, Keshavarzpoor Lonbar A, Mehraeen E, Sabatier JM. Health Sci Rep2022 Mar5(2):e00516http://www.ncbi.nlm.nih.gov/pubmed/34412709The effects of hyperbaric oxygen therapy (HBOT) on coronavirus disease-2019 (COVID-19): a systematic review. Eur J Med Res. 2021 Aug 19; 26(1):96.Oliaei S, SeyedAlinaghi S, Mehrtak M, Karimi A, Noori T, Mirzapour P, Shojaei A, MohsseniPour M, Mirghaderi SP, Alilou S, Shobeiri P, Azadi Cheshmekabodi H, Mehraeen E, Dadras O. Eur J Med Res2021 Aug 1926(1):96http://www.ncbi.nlm.nih.gov/pubmed/34302737Effects of Androgen Deprivation Therapy on COVID-19 in Patients with Prostate Cancer: A Systematic Review and Meta-Analysis. Urol J. 2021 07 24; 18(6):577-584.Karimi A, Nowroozi A, Alilou S, Amini E. Urol J2021 07 2418(6):577-584http://www.ncbi.nlm.nih.gov/pubmed/33866537Indirect Factors Affecting Fertility in the Era of COVID-19. Urol J. 2021 04 18; 18(3):358.Karimi A, Nowroozi A, Alilou S, Amini E. Urol J2021 04 1818(3):358http://www.ncbi.nlm.nih.gov/pubmed/33767992Adverse Events Following Administration of Anti-CTLA4 Antibody Ipilimumab. Front Oncol. 2021; 11:624780.Karimi A, Alilou S, Mirzaei HR. Front Oncol202111:624780http://www.ncbi.nlm.nih.gov/pubmed/33423246Adjuvant vs. salvage Radiation Therapy after Radical Prostatectomy: Role of Decipher® in the Era of Personalized Medicine. Urol J. 2021 Jan 10; 18(3):349-350.Nowroozi A, Karimi A, Alilou S, Amini E. Urol J2021 Jan 1018(3):349-350http://www.ncbi.nlm.nih.gov/pubmed/33357637A systematic review of ECG findings in patients with COVID-19. Indian Heart J. 2020 Nov-Dec; 72(6):500-507.Mehraeen E, Seyed Alinaghi SA, Nowroozi A, Dadras O, Alilou S, Shobeiri P, Behnezhad F, Karimi A. Indian Heart J2020 Nov-Dec72(6):500-507http://www.ncbi.nlm.nih.gov/pubmed/32633262Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention. Turk Kardiyol Dern Ars. 2020 07; 48(5):472-483.Kiani R, Alilou S, Rafatnia S, Taslimi Y, Habibzadeh S, Gharibzadeh S, Firouzi A, Rahim S, Zahedmehr A, Mehrvarz F, Moghadam Ahari M, Sadeghipour P. Turk Kardiyol Dern Ars2020 0748(5):472-483http://www.ncbi.nlm.nih.gov/pubmed/32338153Effect of drug-coated balloons versus bare-metal stents on endothelial function in patients with severe lower limb peripheral artery disease. Vascular. 2020 Oct; 28(5):548-556.Shafe O, Moosavi J, Shishehbor MH, Sedigh H, Bakhshandeh H, Mahboubian F, Alilou S, Rafatnia S, Sadeghipour P. Vascular2020 Oct28(5):548-556http://www.ncbi.nlm.nih.gov/pubmed/31896801Keratopigmentation: a comprehensive review. Eye (Lond). 2020 06; 34(6):1039-1046.Hasani H, Es'haghi A, Rafatnia S, Alilou S, Abolmaali M. Eye (Lond)2020 0634(6):1039-1046Infusions, Intraosseous19.150066631851589e-0012025-03-19T00:00:002025-03-19T00:00:00Out-of-Hospital Cardiac Arrest16.366621042518024e-0012025-03-19T00:00:002025-03-19T00:00:00Pulmonary Fibrosis15.916102444707759e-0012023-06-06T00:00:002023-06-06T00:00:00Bariatric Surgery25.180892470681502e-0012024-04-27T00:00:002025-08-28T00:00:00Obesity, Morbid13.897422698012190e-0012024-04-27T00:00:002024-04-27T00:00:00COVID-19102.976717859849709e-0012020-11-13T00:00:002023-08-04T00:00:00Biomarkers52.239648598903073e-0012022-11-01T00:00:002024-04-27T00:00:00Fenofibrate11.903204952372116e-0012023-05-08T00:00:002023-05-08T00:00:00Dermal Fillers11.792962708186437e-0012022-05-31T00:00:002022-05-31T00:00:00Heart Injuries11.687295228072444e-0012022-11-01T00:00:002022-11-01T00:00:00Cosmetics11.682540346288539e-0012022-05-31T00:00:002022-05-31T00:00:00Postoperative Complications11.680694308745601e-0012024-04-27T00:00:002024-04-27T00:00:00No-Reflow Phenomenon11.653161339092070e-0012020-07-01T00:00:002020-07-01T00:00:00Hyperbaric Oxygenation11.628817587919259e-0012021-08-19T00:00:002021-08-19T00:00:00Cosmetic Techniques11.537941248100299e-0012022-05-31T00:00:002022-05-31T00:00:00Corneal Opacity11.535920917787754e-0012020-01-02T00:00:002020-01-02T00:00:00Glucagon-Like Peptide-1 Receptor Agonists11.527411641337221e-0012025-08-28T00:00:002025-08-28T00:00:00Tattooing11.515684834185492e-0012020-01-02T00:00:002020-01-02T00:00:00Respiratory Sounds11.472688156119074e-0012023-06-06T00:00:002023-06-06T00:00:00Percutaneous Coronary Intervention21.450071697955755e-0012020-07-01T00:00:002022-11-01T00:00:00COVID-19 Vaccines21.367825024791926e-0012022-03-23T00:00:002022-05-31T00:00:00Nitric Oxide Synthase Type III11.326274031235362e-0012020-07-01T00:00:002020-07-01T00:00:00Intermittent Claudication11.317429278627442e-0012020-04-26T00:00:002020-04-26T00:00:00Coated Materials, Biocompatible11.309650354128145e-0012020-04-26T00:00:002020-04-26T00:00:00Cardiopulmonary Resuscitation11.222473784144492e-0012025-03-19T00:00:002025-03-19T00:00:00Fertility11.199767175707132e-0012021-04-18T00:00:002021-04-18T00:00:00Vasodilation11.196723627662413e-0012020-04-26T00:00:002020-04-26T00:00:00Angioplasty, Balloon11.183084345588158e-0012020-04-26T00:00:002020-04-26T00:00:00Metals11.153658753778855e-0012020-04-26T00:00:002020-04-26T00:00:00Weight Gain11.136384086067120e-0012025-08-28T00:00:002025-08-28T00:00:00ST Elevation Myocardial Infarction11.109853019103352e-0012020-07-01T00:00:002020-07-01T00:00:00RNA, Long Noncoding11.083832711447147e-0012023-03-22T00:00:002023-03-22T00:00:00Fatty Acids, Omega-311.015067255249335e-0012023-05-08T00:00:002023-05-08T00:00:00Prostatectomy19.557420453636817e-0022021-01-10T00:00:002021-01-10T00:00:00C-Reactive Protein19.223495361576661e-0022024-04-27T00:00:002024-04-27T00:00:00SARS-CoV-269.048971317170268e-0022020-11-13T00:00:002023-06-06T00:00:00Lower Extremity18.631290487233903e-0022020-04-26T00:00:002020-04-26T00:00:00Arrhythmias, Cardiac18.296585307627638e-0022020-11-13T00:00:002020-11-13T00:00:00Randomized Controlled Trials as Topic28.055386900269927e-0022023-05-08T00:00:002025-03-19T00:00:00Prostatic Neoplasms27.022232280534931e-0022021-01-10T00:00:002021-07-24T00:00:00Hydroxymethylglutaryl-CoA Reductase Inhibitors16.995623275470024e-0022023-05-08T00:00:002023-05-08T00:00:00Endothelium, Vascular16.984964536898668e-0022020-04-26T00:00:002020-04-26T00:00:00Stents16.810043091032078e-0022020-04-26T00:00:002020-04-26T00:00:00Peripheral Arterial Disease16.681032645409991e-0022020-04-26T00:00:002020-04-26T00:00:00Predictive Value of Tests16.663861471553506e-0022024-04-27T00:00:002024-04-27T00:00:00Electrocardiography16.505017105485400e-0022020-11-13T00:00:002020-11-13T00:00:00Precision Medicine16.380667994419374e-0022021-01-10T00:00:002021-01-10T00:00:00Humans206.304831516117410e-0022020-01-02T00:00:002025-08-28T00:00:00Disease Progression15.942038764145134e-0022023-06-06T00:00:002023-06-06T00:00:00Atrial Fibrillation15.462714160138769e-0022023-10-09T00:00:002023-10-09T00:00:00Lung15.374122179310682e-0022023-06-06T00:00:002023-06-06T00:00:00Coronary Artery Disease14.813777731709994e-0022022-11-01T00:00:002022-11-01T00:00:00Syndecan-114.778438485918948e-0022023-08-04T00:00:002023-08-04T00:00:00Africa, Northern14.514325378723774e-0022022-03-23T00:00:002022-03-23T00:00:00Myocardial Infarction14.509960254464710e-0022022-11-01T00:00:002022-11-01T00:00:00Galectin 314.412969205737059e-0022023-10-09T00:00:002023-10-09T00:00:00Middle East14.240955560238396e-0022022-03-23T00:00:002022-03-23T00:00:00Polymorphism, Single Nucleotide14.222453526981161e-0022020-07-01T00:00:002020-07-01T00:00:00Alzheimer Disease14.221293062968390e-0022023-03-22T00:00:002023-03-22T00:00:00Galectins14.145329990290170e-0022023-10-09T00:00:002023-10-09T00:00:00PCSK9 Inhibitors14.138741685962169e-0022023-05-08T00:00:002023-05-08T00:00:00Ankle Brachial Index13.821473585332866e-0022020-04-26T00:00:002020-04-26T00:00:00Lipoproteins, LDL13.794689999823087e-0022022-11-01T00:00:002022-11-01T00:00:00Heart Failure13.755880791079509e-0022023-10-09T00:00:002023-10-09T00:00:00Proprotein Convertase 913.727404843628780e-0022023-05-08T00:00:002023-05-08T00:00:00Hyperemia13.624707096756643e-0022020-04-26T00:00:002020-04-26T00:00:00Hypolipidemic Agents13.588142143647507e-0022023-05-08T00:00:002023-05-08T00:00:00Cough13.587199435313281e-0022022-10-22T00:00:002022-10-22T00:00:00Troponin I13.557347987987261e-0022022-11-01T00:00:002022-11-01T00:00:00Hyaluronic Acid13.515750448447414e-0022022-05-31T00:00:002022-05-31T00:00:00Female53.443972860967638e-0022020-04-26T00:00:002024-04-27T00:00:00Blood Proteins13.378632656386663e-0022023-10-09T00:00:002023-10-09T00:00:00Observational Studies as Topic13.348041361652111e-0022023-05-08T00:00:002023-05-08T00:00:00Heart Atria13.327285520322533e-0022023-10-09T00:00:002023-10-09T00:00:00Coloring Agents13.237579386470708e-0022020-01-02T00:00:002020-01-02T00:00:00Patients13.224052241233191e-0022023-08-04T00:00:002023-08-04T00:00:00Vascular Patency13.101938932892593e-0022020-04-26T00:00:002020-04-26T00:00:00Radiotherapy, Adjuvant12.925817094021788e-0022021-01-10T00:00:002021-01-10T00:00:00Fatigue12.862105410455339e-0022022-10-22T00:00:002022-10-22T00:00:00Fever12.796668878066859e-0022022-10-22T00:00:002022-10-22T00:00:00Confidence Intervals12.776752855333990e-0022020-07-01T00:00:002020-07-01T00:00:00Salvage Therapy12.634354913586091e-0022021-01-10T00:00:002021-01-10T00:00:00Coronary Circulation12.623635872010252e-0022020-07-01T00:00:002020-07-01T00:00:00Androgens12.620339576661079e-0022021-07-24T00:00:002021-07-24T00:00:00Weight Loss12.544982367292704e-0022025-08-28T00:00:002025-08-28T00:00:00Male52.473347446176035e-0022020-04-26T00:00:002023-06-06T00:00:00Prosthesis Design12.436729067174374e-0022020-04-26T00:00:002020-04-26T00:00:00COVID-19 Drug Treatment12.378015728620992e-0022021-08-19T00:00:002021-08-19T00:00:00Prognosis22.352982957604913e-0022023-08-04T00:00:002023-10-09T00:00:00Hypoxia12.342557122108140e-0022021-08-19T00:00:002021-08-19T00:00:00Time-to-Treatment12.325511858413006e-0022020-07-01T00:00:002020-07-01T00:00:00Androgen Antagonists12.322758646636908e-0022021-07-24T00:00:002021-07-24T00:00:00Cornea12.277690158448699e-0022020-01-02T00:00:002020-01-02T00:00:00Pandemics22.200594220529264e-0022020-11-13T00:00:002022-03-23T00:00:00Lipids12.184510330185505e-0022022-11-01T00:00:002022-11-01T00:00:00Oxygen11.950547713641444e-0022021-08-19T00:00:002021-08-19T00:00:00Ventricular Function, Left11.884364866018874e-0022022-11-01T00:00:002022-11-01T00:00:00Alleles11.875085138642392e-0022020-07-01T00:00:002020-07-01T00:00:00Vaccination11.874733652334385e-0022022-05-31T00:00:002022-05-31T00:00:00Coronary Angiography11.807415337702341e-0022020-07-01T00:00:002020-07-01T00:00:00Odds Ratio11.768802311013583e-0022020-07-01T00:00:002020-07-01T00:00:00Stroke Volume11.731683659755117e-0022022-11-01T00:00:002022-11-01T00:00:00Sensitivity and Specificity11.691558974225128e-0022023-03-22T00:00:002023-03-22T00:00:00Comorbidity11.511788822257629e-0022020-11-13T00:00:002020-11-13T00:00:00Prospective Studies21.434493306067202e-0022020-04-26T00:00:002020-07-01T00:00:00Clinical Trials as Topic11.408250852685024e-0022021-08-19T00:00:002021-08-19T00:00:00Genomics11.335571192841146e-0022021-01-10T00:00:002021-01-10T00:00:00Treatment Outcome21.274191332758875e-0022020-04-26T00:00:002021-08-19T00:00:00Severity of Illness Index11.139870353842989e-0022020-04-26T00:00:002020-04-26T00:00:00Middle Aged31.105261610489075e-0022020-04-26T00:00:002022-05-31T00:00:00Risk Assessment19.358017275752702e-0032021-01-10T00:00:002021-01-10T00:00:00Cross-Sectional Studies18.927254529701853e-0032020-07-01T00:00:002020-07-01T00:00:00Time Factors18.780581465460846e-0032020-04-26T00:00:002020-04-26T00:00:00Child16.538564212249042e-0032022-10-22T00:00:002022-10-22T00:00:00United States16.051225756534136e-0032021-08-19T00:00:002021-08-19T00:00:00Risk Factors15.953219674425007e-0032020-04-26T00:00:002020-04-26T00:00:00Aged13.896807592133206e-0032020-04-26T00:00:002020-04-26T00:00:00Chidumebi Alim, M.D.ChidumebiAlim

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterRadiologyClinical Fellow in RadiologyFellow or Post DocAnie Day Asa Alindogan, Ph.D.Anie DayAlindogan

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryResearch Fellow in SurgeryFellow or Post DocAida Alirezaee, M.D.AidaAlirezaee

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineGastroenterologyResearch Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/39413860Effects of Alpha-Lipoic Acid Supplementation on Weight Loss, Inflammatory, Lipid, and Hematological Levels in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Ren Nutr. 2025 Mar; 35(2):289-299.Rezaei H, Ravankhah M, Ansari M, Alirezaee A, Keshavarzian O, Abdollahi M, Sabet HR. J Ren Nutr2025 Mar35(2):289-299http://www.ncbi.nlm.nih.gov/pubmed/39387006A case report of osteopenia of prematurity. Radiol Case Rep. 2024 Dec; 19(12):6369-6372.Hosseinzadeh V, Mazrooei Rad E, Alirezaee A. Radiol Case Rep2024 Dec19(12):6369-6372http://www.ncbi.nlm.nih.gov/pubmed/38766053Origins and diversity of pan-isotype human bone marrow plasma cells. bioRxiv. 2024 May 10.Pacheco GA, Rao V, Yoo DK, Saghaei S, Tong P, Kumar S, Marini-Rapoport O, Allahyari Z, Moghaddam AS, Esbati R, Alirezaee A, Parnes A, Patil SU, Wesemann DR. bioRxiv2024 May 10Thioctic Acid12.190769795274491e-0012024-10-15T00:00:002024-10-15T00:00:00Lipids11.000599321649381e-0012024-10-15T00:00:002024-10-15T00:00:00Weight Loss19.585580413956964e-0022024-10-15T00:00:002024-10-15T00:00:00Dietary Supplements18.550478858577064e-0022024-10-15T00:00:002024-10-15T00:00:00Renal Insufficiency, Chronic17.855222459612758e-0022024-10-15T00:00:002024-10-15T00:00:00Inflammation15.266921273395383e-0022024-10-15T00:00:002024-10-15T00:00:00C-Reactive Protein12.381929693701866e-0022024-10-15T00:00:002024-10-15T00:00:00Randomized Controlled Trials as Topic11.603251385695481e-0022024-10-15T00:00:002024-10-15T00:00:00Humans12.435025816935841e-0032024-10-15T00:00:002024-10-15T00:00:00Ron Noah Alkalay, Ph.D.RonAlkalay

Beth Israel Deaconess Medical CenterCenter for Advanced Orthopedic Studies1 Overland StreetBoston, MA 02215617/667-518542.37840800000000-71.11650810000000

1BIDMCBeth Israel Deaconess Medical CenterOrthopedic SurgeryAssociate Professor of Orthopedic SurgeryAssociate ProfessorCo-InvestigatorBIOELASTIC MATERIAL TO PREVENT POST-LAMINECTOMY ADHESIONNIH1997-03-012002-06-30XU, JIEUsing two biocompatible elastic protein-based polymers (in viscolelastic gel and elastic sheet forms), the Phase I study demonstrated both materials to be highly effective in preventing adhesions to the spinal dura in the rabbit laminectomy model. The specific aims of Phase II are: 1) to identify the preferred membrane and/or gel configuration(s) of two biocompatible and resorbable polymer compositions for prevention of adhesions in a large animal laminectomy model, 2) to develop sensitive double radio-label standards for purification and a quality control protocol, 3) to utilize an adult sheep lumbar spine model with laminectomies performed at two non-contiguous levels (L3-L4 and L5-L6) allowing for a randomization of the polymer placement to surgical site, 4) to develop a mechanical test method for assessing the interface between the dura mater and the tested polymer and the epidural fibrotic tissue at the control site, and 5) to complete biocompatibility testing and prepare an IDE application for the preferred polymer(s) and state(s). The physical disability resulting from intervertebral disc herniation constitutes the third most common condition for worker disability in the U.S. An improved outcome of intervertebral disc laminectomy would improve the quality of life and restore function for many millions of disabled Americans. PROPOSED COMMERCIAL APPLICATION: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other medical condition and in an annual health care cost of $33 billion. Over four million cases of prolapsed intervertebral discs are reported annually in the U.S. Development of materials that would improve the outcome of intervertebral disc laminectomy would clearly be of commercial significance while impacting favorably on medical care costs.Co-InvestigatorBIOELASTIC MATERIAL TO PREVENT POST-LAMINECTOMY ADHESIONNIH1997-03-012003-06-30XU, JIEUsing two biocompatible elastic protein-based polymers (in viscolelastic gel and elastic sheet forms), the Phase I study demonstrated both materials to be highly effective in preventing adhesions to the spinal dura in the rabbit laminectomy model. The specific aims of Phase II are: 1) to identify the preferred membrane and/or gel configuration(s) of two biocompatible and resorbable polymer compositions for prevention of adhesions in a large animal laminectomy model, 2) to develop sensitive double radio-label standards for purification and a quality control protocol, 3) to utilize an adult sheep lumbar spine model with laminectomies performed at two non-contiguous levels (L3-L4 and L5-L6) allowing for a randomization of the polymer placement to surgical site, 4) to develop a mechanical test method for assessing the interface between the dura mater and the tested polymer and the epidural fibrotic tissue at the control site, and 5) to complete biocompatibility testing and prepare an IDE application for the preferred polymer(s) and state(s). The physical disability resulting from intervertebral disc herniation constitutes the third most common condition for worker disability in the U.S. An improved outcome of intervertebral disc laminectomy would improve the quality of life and restore function for many millions of disabled Americans. PROPOSED COMMERCIAL APPLICATION: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other medical condition and in an annual health care cost of $33 billion. Over four million cases of prolapsed intervertebral discs are reported annually in the U.S. Development of materials that would improve the outcome of intervertebral disc laminectomy would clearly be of commercial significance while impacting favorably on medical care costs.Co-InvestigatorBIOELASTIC MATERIALS FOR INTERVERTEBRAL DISC RESTORATIONNIH1999-04-012000-03-31PATTANAIK, ASIMAThe broad, long term objective of this application is to provide a markedly less expensive, minimally invasive treatment for low back pain arising from intervertebral disc pathology. The specific alms are: 1) to design pressure-active and biocompatible viscoelastic protein-based polymers i) to effect proper intra-disc pressure development on implantation in the nucleus pulposus for mechanical restoration of the compressed disc to its correct dimensions and internal pressure and ii) to stimulate tissue reconstruction for structural restoration of the intervertebral disc to its more natural state, 2) to evaluate the diseased state of human cadaver lumbar spines and to select appropriate diseased states for implantation of bioelastic polymers, 3) to perform mechanical studies on the selected lumbar spine segments (L1-L5) to assess efficacy of implanted viscoelastic protein-based polymers in restoring proper mechanical properties to diseased intervertebral discs, 4) to genetically engineer four specially designed bioelastic polymers for production by microbial biosynthesis, and 5) to plan in vivo animal model studies using the four designed bioelastic polymers in Phase II wherein injured intervertebral discs could be studied for efficacy of designed bioelastic polymers to restore the normal state. Success could, annually in the U.S. alone, return millions to work and reduce health care costs by tens of billions of dollars. PROPOSED COMMERCIAL APPLICATIONS: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other medical condition and a health care cost of $33 billion dollars/year. Over 4 million cases of prolapsed intervertebral discs are reported annually in the U.S. Development of materials to restore diseased intervertebral discs would be of commercial significance and would impact favorably on medical care costs.Co-InvestigatorBIOELASTIC MATERIALS FOR INTERVERTEBRAL DISC RESTORATIONNIH1999-04-012000-03-31PATTANAIK, ASIMAThe broad, long term objective of this application is to provide a markedly less expensive, minimally invasive treatment for low back pain arising from intervertebral disc pathology. The specific alms are: 1) to design pressure-active and biocompatible viscoelastic protein-based polymers i) to effect proper intra-disc pressure development on implantation in the nucleus pulposus for mechanical restoration of the compressed disc to its correct dimensions and internal pressure and ii) to stimulate tissue reconstruction for structural restoration of the intervertebral disc to its more natural state, 2) to evaluate the diseased state of human cadaver lumbar spines and to select appropriate diseased states for implantation of bioelastic polymers, 3) to perform mechanical studies on the selected lumbar spine segments (L1-L5) to assess efficacy of implanted viscoelastic protein-based polymers in restoring proper mechanical properties to diseased intervertebral discs, 4) to genetically engineer four specially designed bioelastic polymers for production by microbial biosynthesis, and 5) to plan in vivo animal model studies using the four designed bioelastic polymers in Phase II wherein injured intervertebral discs could be studied for efficacy of designed bioelastic polymers to restore the normal state. Success could, annually in the U.S. alone, return millions to work and reduce health care costs by tens of billions of dollars. PROPOSED COMMERCIAL APPLICATIONS: Low back pain, for which intervertebral disc pathology is the major cause, is second only to the common cold for work absenteeism in the United States; it is reported to result in more productivity loss than any other medical condition and a health care cost of $33 billion dollars/year. Over 4 million cases of prolapsed intervertebral discs are reported annually in the U.S. Development of materials to restore diseased intervertebral discs would be of commercial significance and would impact favorably on medical care costs.Principal InvestigatorPre-Operative QCT Planning Protocol for Treating the Structural Deficiency of SpiNIH2008-07-032013-04-30ALKALAY, RON NThe spine is the skeletal site most often affected by metastatic breast cancer, and 17-50% of patients with spinal metastasis sustain a vertebral fracture. Systemic treatments with cytotoxic agents, hormone manipulation, bisphosphonates and/or local treatment with radiation and/or surgical stabilization, constitute the range of therapies available to breast cancer patients with skeletal metastasis. However, there are no objective methods for selecting which treatment will best reduce the patient's risk for sustaining a pathologic fracture and for monitoring the patient's response to therapy. Therefore, establishing objective criteria to evaluate the load carrying capacity of the involved vertebrae can be used both to monitor changes in bone structure that reflect the interaction of the tumor with the host bone, and to guide treatment for fracture prevention. Objective measures of fracture risk will both enhance patient management and resource utilization. Our overall hypothesis is that the loss of structural integrity of the spine due to tumor induced osteolysis, assessed using CT based structural analysis protocol, can be restored using structural polymers deployed in a minimally invasive manner. In Aim 1, in a series of in vitro tests, the ability of a QCT based structural analysis protocol to classify the fracture risk of thoracolumbar human spines with simulated critical osteolytic defects will be quantified under physiological loading conditions. Predicated fracture load, computed for the vertebrae, will be compared to the failure load measured by mechanical testing. The role of spinal ligaments in effecting the predicted failure load will be investigated. In Aim 2, a novel image-based algorithm will be developed and integrated within the CT structural analysis protocol, to provide pre-operative planning for prophylactic augmentation of the affected vertebra. Specific anatomically and materially detailed computational models will be used to optimize the design rules incorporated within the image based module to achieve restoration of the structural integrity of the affected vertebra. Using a series of in vitro studies, we will characterize the dependencies of the mechanical properties of treated vertebrae on the material properties of the injectable biopolymer and the geometrical properties of the lytic defect. We will compare this performance to the use of Polymethylmetacrylate cement. In Aim 3, the efficacy of the developed CT based pre-operative analysis, prediction and augmentation system, in restoring the structural integrity of thoracolumbar spines with simulated lytic defects, will be quantified. In summary, Drawing on principles of structural engineering, a novel CT based pre-operative analysis, prediction and augmentation system, will be developed to allow pre-operative planning for prophylactic augmentation of the human thoracolumbar spines with critical lytic defects. Principal InvestigatorLesion-specific QCT Improves Prediction of Pathologic Vertebrae Fracture LoadNIH2015-04-012017-10-31ALKALAY, RON N? DESCRIPTION (provided by applicant): Pathologic Vertebral Fractures (PVF), associated with intractable pain, loss of function and severe neurologic compromise in up to 50% of patients with spinal metastases, represent the most dreaded complication associated with this condition. Lung, breast and prostate cancer are the leading causes of cancer death in the western world and vertebral bone is the most frequent site of skeletal metastasis. Current guidelines for estimating fracture risk for pathologic vertebra remain poorly defined with low specificity and sensitivity. The quantitative computed tomography structural analysis protocol (QCT-SAP) for prediction of pathologic vertebral fracture relies upon computing bone modulus and strength based on the relationship between CT number and bone density. By quantifying the effect of the lesion on the strength of the cancellous bone (architecture and density) and the structural load carrying capacity of the vertebra (cross sectional properties), we and others have shown this method to offer improved predictive accuracy compared to that reported for current radiological guidelines. However this CT - bone modulus relationship was established for non-pathologic bone only, and it may not account for the deleterious effects of metastatic lesions on the composition and material properties as well as architectural efficiency of the vertebral bone, that forms a critical portion of load carrying capacity of the human vertebra. Based on our experimental, image analysis and computational work, we will apply a multiscale approach to determine the deleterious effect of lytic (LM) and blastic (BM) metastasis on the compositional and material properties and architectural efficiency of vertebral bone. These properties will be compared to bone obtained from adjacent vertebrae showing no radiographic evidence of metastasis (internal control) and from age/sex matched vertebral levels from donors with no history of cancer (external control). Using both experimental and computational models we will establish LM- and BM- specific relationships between CT and bone modulus and implemented these models in QCT-SAP. In addition, for the lesion specific models, we will incorporate patient specific factors (co-morbidities, radiation, antiresorptive treatment) found to significantly affec the model. We will then test whether the improvement in prediction accuracy of the lesion specific QCT- SAP exceeds 10%, a difference deemed to be clinically important. Finally, we will compare the improved accuracy of the lesion and patient specific QCT-SAP to that of the current non-specific QCT-SAP, in predicting the structural response of complete lumbar human spines under functional loads. This aim establishes whether metastatic specific material models significantly improve the accuracy of CT-SAP in predicting failure of pathologic spines. By providing quantitative, sensitive and objective, assessment of the change in the skeletal status of the patient, we expect this novel approach to enable robustly informed treatment decisions and thus improve patient management and outcome.Principal InvestigatorPredicting Fracture Risk in Patients Treated with Radiotherapy for Spinal Metastatic DiseaseNIH2019-09-252020-03-31ALKALAY, RON NProject Summary/Abstract We seek to improve the prediction of the risk of pathologic vertebral fracture (PVF) in patients who are treated with radiotherapy for bone metastases in the spine. Vertebral bone is the most frequent site of skeletal metastasis. Radiation therapy aims to palliate pain and reduce the risk of pathologic vertebral fracture. However, vertebral fractures are a common complication afflicting up to 39% of patients within 6 months after- radiotherapy. Clinical guidelines for estimating fracture risk remain subjective and suffer from low specificity and sensitivity. Improved assessment of fracture risk would facilitate selection of whether, how, and when to intervene prior to the occurrence of fractures. Such individualized prediction is not available in clinical practice. As part of our previous NIH grant, we have developed a computed tomography (CT) based structural analysis (CT-SAP) to successfully predict the failure of human spines with lytic defects. Based on these accomplishments, the objectives of this observational prospective study are threefold: 1) To test the performance of CT-SAP (providing a snapshot of bone structure and calcium content) and bone turnover markers (providing an indication of disease trajectory) for predicting the baseline risk of vertebral fractures in a cohort of patients treated with radiotherapy for spinal bone metastases. For this purpose, we will acquire the standard clinical CT and serum sample at the patient's radiotherapy planning. From the CT, we will derive individualized estimates of vertebral strength (CT-SAP) and vertebral loading to compute the loading / strength ratio for both treated and untreated vertebrae, and measure the value for markers for bone resorption and formation from the serum sample. We will test the independent association of the vertebral loading / strength ratio and marker value with the observed vertebral fractures within 6 months after treatment. This novel data will provide information on the effect of radiation and metastatic disease on the baseline and short term risk of vertebral fracture in this patient cohort. 2) To establish the performance of the spinal instability neoplastic score (SINS) for predicting the patient's risk of vertebral fracture within 6 months after treatment and test whether adding the load / strength ratio (CT-SAP) and bone turnover risk models, independently and combined, improves the model's performance. This will establish a new paradigm for individualized prediction of baseline risk for fracture in this patient cohort. 3) To test the established model performance for predicting the evolving risk of PVF within a 3 month interval by acquiring and analyzing the CT scans and serum samples collected at 3, 6, and 9 months after treatment as part of standard clinical care. This time period provides clinically meaningful guidelines for assessing the impact of a low vs. high risk of PVF to the health and quality of life of this infirm population with short life expectancy. Successful completion of this project will address a critical gap in our ability to individualize evaluation and management of these patients.Principal InvestigatorPredicting Fracture Risk in Patients Treated with Radiotherapy for Spinal Metastatic DiseaseNIH2020-04-012025-03-31ALKALAY, RON NPrincipal InvestigatorThis administrative supplement proposal to improve the AI/ML-readiness aims to establish a curated, publicly accessible, 4D clinical and imaging dataset enabling the advancement of deep learning methods to analyze disease progression and fracture risk in patients with metastatic spine disease. Developing expert-driven deep learning systems will improve insight into the drivers of PVF risk in patients with metastatic spine disease.Curating musculoskeletal CT data to enable the development of AI/ML approaches for analysis of clinical CT in patients with metastatic spinal diseaseNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022-09-152026-05-31Alkalay RonProject Summary/Abstract Vertebral bone metastases, widespread in patients with cancer, destroy vertebral anatomy, bone architecture, and mechanical strength, exposing patients to a high risk of pathologic vertebral fracture (PVF). PVFs cause neurological deficits in up to 50% of patients, with further complications that may be fatal. Our parent grant (AR075964) develops and validates a novel computational musculoskeletal approach for patient-specific, precise prediction of PVF risk from clinical CT. Segmentation of vertebral anatomy, bone properties, and individual spinal musculature cross-sectional area from clinical CT imaging, a fundamental step for assembling the computational musculoskeletal models, faces unique challenges due to the cancer-mediated alteration in skeletal tissues' radiological appearance. Application of deep learning (DL) methods will speed and standardize the critical segmentation step, permitting analysis of larger datasets, promoting new DL analysis for improved insight into the drivers of PVF risk in patients with metastatic spine disease. This development is hindered by the lack of publicly available, clinically annotated image data specific to metastatic human spines. This proposal aims to establish a curated, publicly accessible, 4D CT imaging dataset of human metastatic spines and associated radiological delineations of lesions and vertebral features, to enable the advancement of DL methods to analyze PVF risk. We thus propose three specific aims: 1) prepare the CT dataset for the application of deep learning: Our data is based on our parent grant (AR075964) de-identified spinal column and thoracoabdominal muscles CT image datasets obtained from 140 patients at radiation planning and additional CT diagnostic data at 3, 6, 9, and 12 months follow up (1400 image data sets overall). We will assemble and curate the data for public distribution by a) preprocessing the CT images for machine learning applications, b) delineating the vertebrae, lesions, and muscles in the images, c) assembling metadata, including limited subject demographic and disease status into JSON files, and d) extract SIFT features for computer-vision style analyses. 2) Testbed Deep Learning (DL) Segmentation: To ensure that the curated data set is suitable for training artificial intelligence and machine learning (AI/ML) systems, we will develop and train testbed DL segmentation networks to segment bones, lesions, and muscles in baseline and follow-up clinical CT. We will use the networks to control the quality the curated CT images and delineations, 3) Disseminate 4D dataset following best practices: Upon completion of tasks 1 and 2, we will make the data available to the research community via the Cancer Image Archive (TCIA) following their established methods for de-identifying DICOM scans and annotating and encoding clinical data and analysis results. Integrating DL systems within our approach will change the patient management paradigm from reactive to data-driven, proactive management to prevent PVF events and critically reduce bias in patient management.http://www.ncbi.nlm.nih.gov/pubmed/41704934Automated segmentation of trunk musculature with a deep CNN trained from sparse annotations in radiation therapy patients with metastatic spine disease: an observational study. Front Bioeng Biotechnol. 2025; 13:1707724.Hong V, Pieper S, James J, Anderson DE, Pinter C, Chang YS, Bulent A, Kozono D, Doyle P, Caplan S, Kang H, Balboni T, Spektor A, Keko M, Kikinis R, Hackney DB, Alkalay RN. Front Bioeng Biotechnol202513:1707724http://www.ncbi.nlm.nih.gov/pubmed/41502905Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals. JOR Spine. 2026 Mar; 9(1):e70111.Anderson DE, Keko M, James J, Allaire BT, Kozono D, Doyle PF, Kang H, Caplan S, Balboni T, Spektor A, Huynh MA, Bouxsein ML, Hackney DB, Alkalay RN. JOR Spine2026 Mar9(1):e70111http://www.ncbi.nlm.nih.gov/pubmed/40548161Spinal Instability Neoplastic Score as a Predictor of Vertebral Fracture in Patients Undergoing Radiation Therapy for Spinal Metastases: A Single-Institution Study. Adv Radiat Oncol. 2025 Jul; 10(7):101803.Doyle P, Caplan S, Klinger N, Shin KY, Groff M, Dillon-Martin M, Johnson T, Kang H, Perkins T, Novack C, Spektor A, Huynh MA, Kim E, Tanguturi S, Richards C, Xu WV, Kozono D, Alkalay R, Hackney D, Balboni T. Adv Radiat Oncol2025 Jul10(7):101803http://www.ncbi.nlm.nih.gov/pubmed/39484265An open annotated dataset and baseline machine learning model for segmentation of vertebrae with metastatic bone lesions from CT. medRxiv. 2024 Nov 12.Haouchine N, Hackney DB, Pieper SD, Wells WM, Sanhinova M, Balboni TA, Spektor A, Huynh MA, Kozono DE, Doyle P, Alkalay RN. medRxiv2024 Nov 12http://www.ncbi.nlm.nih.gov/pubmed/39108596CT-based finite element simulating spatial bone damage accumulation predicts metastatic human vertebrae strength and stiffness. Front Bioeng Biotechnol. 2024; 12:1424553.Soltani Z, Xu M, Radovitzky R, Stadelmann MA, Hackney D, Alkalay RN. Front Bioeng Biotechnol202412:1424553http://www.ncbi.nlm.nih.gov/pubmed/39310216Registration of Longitudinal Spine CTs for Monitoring Lesion Growth. Proc SPIE Int Soc Opt Eng. 2024 Feb; 12926.Sanhinova M, Haouchine N, Pieper SD, Wells WM, Balboni TA, Spektor A, Huynh MA, Guenette JP, Czajkowski B, Caplan S, Doyle P, Kang H, Hackney DB, Alkalay RN. Proc SPIE Int Soc Opt Eng2024 Feb12926http://www.ncbi.nlm.nih.gov/pubmed/35992350Evaluation of Load-To-Strength Ratios in Metastatic Vertebrae and Comparison With Age- and Sex-Matched Healthy Individuals. Front Bioeng Biotechnol. 2022; 10:866970.Anderson DE, Groff MW, Flood TF, Allaire BT, Davis RB, Stadelmann MA, Zysset PK, Alkalay RN. Front Bioeng Biotechnol202210:866970http://www.ncbi.nlm.nih.gov/pubmed/35253282Influence of Metastatic Bone Lesion Type and Tumor Origin on Human Vertebral Bone Architecture, Matrix Quality, and Mechanical Properties. J Bone Miner Res. 2022 05; 37(5):896-907.Bailey S, Stadelmann MA, Zysset PK, Vashishth D, Alkalay RN. J Bone Miner Res2022 0537(5):896-907http://www.ncbi.nlm.nih.gov/pubmed/34479191Improved estimates of strength and stiffness in pathologic vertebrae with bone metastases using CT-derived bone density compared with radiographic bone lesion quality classification. J Neurosurg Spine. 2022 Jan 01; 36(1):113-124.Alkalay RN, Groff MW, Stadelmann MA, Buck FM, Hoppe S, Theumann N, Mektar U, Davis RB, Hackney DB. J Neurosurg Spine2022 Jan 0136(1):113-124http://www.ncbi.nlm.nih.gov/pubmed/33755638Large Lytic Defects Produce Kinematic Instability and Loss of Compressive Strength in Human Spines: An in Vitro Study. J Bone Joint Surg Am. 2021 05 19; 103(10):887-899.Alkalay RN, Adamson R, Miropolsky A, Davis RB, Groff ML, Hackney DB. J Bone Joint Surg Am2021 05 19103(10):887-899Compared to the radiographic bone lesion quality classification of bone metastases, CT-derived bone density offers improved estimates of pathologic vertebrae's strength and stiffness. Journal of Neurosurgery: Spine, (Accepted for publication). 2021.Ron N. Alkalay, Michael W. Groff, Marc A. Stadelmann, Florian M. Buck, Sven Hoppe, Nicolas Theumann, Umesh Mektar, Roger B Davis and David B. Hackney. Journal of Neurosurgery: Spine, (Accepted for publication)2021http://www.ncbi.nlm.nih.gov/pubmed/32829037Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure. Bone. 2020 12; 141:115598.Stadelmann MA, Schenk DE, Maquer G, Lenherr C, Buck FM, Bosshardt DD, Hoppe S, Theumann N, Alkalay RN, Zysset PK. Bone2020 12141:115598http://www.ncbi.nlm.nih.gov/pubmed/32543225Finite element models can reproduce the effect of nucleotomy on the multi-axial compliance of human intervertebral discs. Comput Methods Biomech Biomed Engin. 2020 Oct; 23(13):934-944.Stadelmann MA, Stocker R, Maquer G, Hoppe S, Vermathen P, Alkalay RN, Zysset PK. Comput Methods Biomech Biomed Engin2020 Oct23(13):934-944http://www.ncbi.nlm.nih.gov/pubmed/31759204The effects of metastatic lesion on the structural determinants of bone: Current clinical and experimental approaches. Bone. 2020 09; 138:115159.Bailey S, Hackney D, Vashishth D, Alkalay RN. Bone2020 09138:115159http://www.ncbi.nlm.nih.gov/pubmed/30458331Diffusion based MR measurements correlates with age-related changes in human intervertebral disks. Clin Biomech (Bristol). 2019 01; 61:38-45.Alkalay R, David H. Clin Biomech (Bristol)2019 0161:38-45http://www.ncbi.nlm.nih.gov/pubmed/29869960Female Human Spines with Simulated Osteolytic Defects: CT-based Structural Analysis of Vertebral Body Strength. Radiology. 2018 08; 288(2):436-444.Alkalay R, Adamson R, Miropolsky A, Hackney D. Radiology2018 08288(2):436-444http://www.ncbi.nlm.nih.gov/pubmed/29843094Integrating MRI-based geometry, composition and fiber architecture in a finite element model of the human intervertebral disc. J Mech Behav Biomed Mater. 2018 09; 85:37-42.Stadelmann MA, Maquer G, Voumard B, Grant A, Hackney DB, Vermathen P, Alkalay RN, Zysset PK. J Mech Behav Biomed Mater2018 0985:37-42http://www.ncbi.nlm.nih.gov/pubmed/29526639The effect of interbody fusion cage design on the stability of the instrumented spine in response to cyclic loading: an experimental study. Spine J. 2018 10; 18(10):1867-1876.Alkalay RN, Adamson R, Groff MW. Spine J2018 1018(10):1867-1876http://www.ncbi.nlm.nih.gov/pubmed/26748564Mechanical assessment of the effects of metastatic lytic defect on the structural response of human thoracolumbar spine. J Orthop Res. 2016 10; 34(10):1808-1819.Alkalay RN, Harrigan TP. J Orthop Res2016 1034(10):1808-1819http://www.ncbi.nlm.nih.gov/pubmed/25912639Augmentation of failed human vertebrae with critical un-contained lytic defect restores their structural competence under functional loading: An experimental study. Clin Biomech (Bristol). 2015 Jul; 30(6):608-16.Alkalay RN, von Stechow D, Hackney DB. Clin Biomech (Bristol)2015 Jul30(6):608-16http://www.ncbi.nlm.nih.gov/pubmed/25586264Effect of the metastatic defect on the structural response and failure process of human vertebrae: an experimental study. Clin Biomech (Bristol). 2015 Feb; 30(2):121-8.Alkalay RN. Clin Biomech (Bristol)2015 Feb30(2):121-8http://www.ncbi.nlm.nih.gov/pubmed/25579978The degenerative state of the intervertebral disk independently predicts the failure of human lumbar spine to high rate loading: an experimental study. Clin Biomech (Bristol). 2015 Feb; 30(2):211-8.Alkalay RN, Vader D, Hackney D. Clin Biomech (Bristol)2015 Feb30(2):211-8http://www.ncbi.nlm.nih.gov/pubmed/24889510MR diffusion is sensitive to mechanical loading in human intervertebral disks ex vivo. J Magn Reson Imaging. 2015 Mar; 41(3):654-64.Alkalay RN, Burstein D, Westin CF, Meier D, Hackney DB. J Magn Reson Imaging2015 Mar41(3):654-64http://www.ncbi.nlm.nih.gov/pubmed/25024122Effect of the Degenerative State of the Intervertebral Disk on the Impact Characteristics of Human Spine Segments. Front Bioeng Biotechnol. 2013; 1:16.Wilson SE, Alkalay RN, Myers E. 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J Spinal Disord Tech2009 Jun22(4):270-7http://www.ncbi.nlm.nih.gov/pubmed/18594454The effect of cement augmentation on the geometry and structural response of recovered osteopenic vertebrae: an anterior-wedge fracture model. Spine (Phila Pa 1976). 2008 Jul 01; 33(15):1627-36.Alkalay RN, von Stechow D, Torres K, Hassan S, Sommerich R, Zurakowski D. Spine (Phila Pa 1976)2008 Jul 0133(15):1627-36http://www.ncbi.nlm.nih.gov/pubmed/17499408Quantitative ultrasound predicts bone mineral density and failure load in human lumbar vertebrae. Clin Biomech (Bristol). 2007 Jul; 22(6):623-9.Nicholson PH, Alkalay R. Clin Biomech (Bristol)2007 Jul22(6):623-9http://www.ncbi.nlm.nih.gov/pubmed/15713308A biomechanical analysis of an instrumented spinal fixator under torsional loads. J Biomech. 2005 Apr; 38(4):865-76.Alkalay RN, Sharpe D, Bader DL. J Biomech2005 Apr38(4):865-76http://www.ncbi.nlm.nih.gov/pubmed/12897488Prevention of postlaminectomy epidural fibrosis using bioelastic materials. 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Computed32.752813926989747e-0012018-06-05T00:00:002021-09-03T00:00:00Equipment Design32.745232985227699e-0011999-01-01T00:00:002013-07-19T00:00:00Fractures, Bone12.667575938059382e-0012019-11-21T00:00:002019-11-21T00:00:00Polymethyl Methacrylate12.624031943144589e-0012008-07-01T00:00:002008-07-01T00:00:00Bone Neoplasms12.558337989144121e-0012019-11-21T00:00:002019-11-21T00:00:00Diffusion Magnetic Resonance Imaging22.458032946607872e-0012014-06-03T00:00:002018-06-18T00:00:00Shear Strength22.102207547452836e-0012014-10-12T00:00:002015-03-28T00:00:00Age Factors22.067560191060604e-0012013-07-19T00:00:002018-06-18T00:00:00Epidural Space11.869685850821860e-0012003-08-01T00:00:002003-08-01T00:00:00Laminectomy11.860544618536745e-0012003-08-01T00:00:002003-08-01T00:00:00Lumbosacral Region21.707521470489116e-0012003-08-01T00:00:002018-06-18T00:00:00Range of Motion, Articular31.658312632999180e-0012014-10-12T00:00:002020-06-16T00:00:00Nucleus Pulposus11.596195135981127e-0012020-06-16T00:00:002020-06-16T00:00:00Torsion Abnormality21.528346133196991e-0012005-04-01T00:00:002013-07-19T00:00:00Models, Biological41.475569631695358e-0011999-01-01T00:00:002021-05-19T00:00:00Pedicle Screws11.319310202730001e-0012018-03-08T00:00:002018-03-08T00:00:00Aged111.315228081301983e-0012012-04-01T00:00:002021-09-03T00:00:00Bone and Bones11.249671417676663e-0012007-05-11T00:00:002007-05-11T00:00:00Fibrosis11.206793798060674e-0012003-08-01T00:00:002003-08-01T00:00:00Polymers11.197239127963832e-0012003-08-01T00:00:002003-08-01T00:00:00Radionuclide Imaging11.178082004165316e-0012019-11-21T00:00:002019-11-21T00:00:00Neoplasms21.156649169044495e-0012020-08-20T00:00:002022-04-05T00:00:00Materials Testing31.148202528321160e-0012001-11-01T00:00:002012-04-01T00:00:00Observer Variation11.142489625752019e-0012021-09-03T00:00:002021-09-03T00:00:00Stress, Mechanical31.118584128525306e-0011999-01-01T00:00:002008-07-01T00:00:00Biocompatible Materials11.114171415828415e-0012003-08-01T00:00:002003-08-01T00:00:00Bone Plates11.072316376492293e-0012018-03-08T00:00:002018-03-08T00:00:00Spinal Diseases19.833240852355267e-0022018-06-18T00:00:002018-06-18T00:00:00Humans219.162523725325077e-0021999-01-01T00:00:002022-04-05T00:00:00Middle Aged88.141619008791889e-0022012-04-01T00:00:002021-09-03T00:00:00Reproducibility of Results27.894068533887380e-0022014-06-03T00:00:002021-09-03T00:00:00Elasticity27.477964690249178e-0021999-01-01T00:00:002003-08-01T00:00:00Absorptiometry, Photon17.198942298141492e-0022014-10-07T00:00:002014-10-07T00:00:00Tumor Microenvironment16.935974565225350e-0022022-04-05T00:00:002022-04-05T00:00:00Female116.924587985768295e-0022001-11-01T00:00:002021-09-03T00:00:00Aged, 80 and over46.774020593072186e-0022012-04-01T00:00:002018-06-18T00:00:00Cattle16.705194321863044e-0022013-07-19T00:00:002013-07-19T00:00:00Calibration26.311854068155423e-0022018-05-17T00:00:002020-06-16T00:00:00Accidental Falls16.131100438516746e-0022014-10-07T00:00:002014-10-07T00:00:00Kyphosis15.953605922388550e-0022009-06-01T00:00:002009-06-01T00:00:00Prostheses and Implants15.638469944485913e-0022012-04-01T00:00:002012-04-01T00:00:00Torque15.514708876487098e-0022005-04-01T00:00:002005-04-01T00:00:00Adult65.263069409214415e-0022012-04-01T00:00:002020-06-16T00:00:00Prosthesis Failure15.148933678727993e-0022009-06-01T00:00:002009-06-01T00:00:00Calcium Sulfate14.496496383800174e-0022001-11-01T00:00:002001-11-01T00:00:00Magnetic Resonance Imaging34.204890051868045e-0022014-10-07T00:00:002020-06-16T00:00:00Male64.039585543112695e-0022012-04-01T00:00:002022-04-05T00:00:00Rabbits23.987593076125817e-0022001-11-01T00:00:002003-08-01T00:00:00Bone Substitutes13.985315800711495e-0022001-11-01T00:00:002001-11-01T00:00:00Sensitivity and Specificity13.676691763596861e-0022014-06-03T00:00:002014-06-03T00:00:00Safety13.652872570089926e-0022003-08-01T00:00:002003-08-01T00:00:00Linear Models13.578298563499206e-0022008-07-01T00:00:002008-07-01T00:00:00Drug Evaluation, Preclinical13.542617513986089e-0022003-08-01T00:00:002003-08-01T00:00:00X-Ray Microtomography13.443981360772969e-0022020-08-20T00:00:002020-08-20T00:00:00Oligopeptides13.408876384084671e-0022003-08-01T00:00:002003-08-01T00:00:00Ultrasonography12.573542788635174e-0022007-05-11T00:00:002007-05-11T00:00:00Risk Assessment12.425241344365594e-0022014-10-07T00:00:002014-10-07T00:00:00Computer Simulation22.304383655410515e-0022009-06-01T00:00:002020-06-16T00:00:00Movement12.263050992030492e-0021999-01-01T00:00:001999-01-01T00:00:00Animals31.713965820677776e-0022001-11-01T00:00:002013-07-19T00:00:00Equipment Failure Analysis11.582974836012385e-0022009-06-01T00:00:002009-06-01T00:00:00Disease Models, Animal11.275335313383248e-0022003-08-01T00:00:002003-08-01T00:00:00Image Processing, Computer-Assisted11.061363542687532e-0022018-05-17T00:00:002018-05-17T00:00:00Postoperative Complications19.979666219730711e-0032003-08-01T00:00:002003-08-01T00:00:00Bone Transplantation17.895903201655518e-0032001-11-01T00:00:002001-11-01T00:00:00Treatment Outcome17.624578426629614e-0032003-08-01T00:00:002003-08-01T00:00:00Models, Animal17.168073907948829e-0032001-11-01T00:00:002001-11-01T00:00:00Electric Stimulation Therapy16.959086313310769e-0032001-11-01T00:00:002001-11-01T00:00:00Radiography15.189183458267719e-0032001-11-01T00:00:002001-11-01T00:00:00Rae Michele Allain, M.D.RaeAllain

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-311242.36241700000000-71.06893700000000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaLecturer on AnaesthesiaLecturerhttp://www.ncbi.nlm.nih.gov/pubmed/41717663Dose-dependent relationship between intra-operative dexmedetomidine and delirium after non-cardiac surgery: a retrospective cohort study. Anaesthesia. 2026 Feb 20.Ahrens E, Wachtendorf LJ, Tenge T, Riesemann S, Kaiser L, Chen G, Neves SE, Robitaille MJ, Xu X, Allain RM, Ma H, Schaefer MS. Anaesthesia2026 Feb 20http://www.ncbi.nlm.nih.gov/pubmed/41048666Development and validation of a prediction score for early identification of palliative care needs for patients in the intensive care unit: a multicentre retrospective cohort study. EClinicalMedicine. 2025 Nov; 89:103519.Tenge T, Hadler R, Mahal E, Ahrens E, Wachtendorf LJ, Redaelli S, Riesemann S, Paschold BS, Chen G, Khan S, Schwartz J, Schallenburger M, Allain RM, Lee K, Neukirchen M, Schaefer MS. EClinicalMedicine2025 Nov89:103519http://www.ncbi.nlm.nih.gov/pubmed/26967801Carotid Artery Stenosis: Anesthetic Considerations for Open and Endovascular Management. Int Anesthesiol Clin. 2016; 54(2):33-51.Kim UR, Allain RM. Int Anesthesiol Clin201654(2):33-51http://www.ncbi.nlm.nih.gov/pubmed/25168636Benefit of using a "bundled" consent for intensive care unit procedures as part of an early family meeting. J Crit Care. 2014 Dec; 29(6):919-22.Dhillon A, Tardini F, Bittner E, Schmidt U, Allain R, Bigatello L. J Crit Care2014 Dec29(6):919-22Case 33-2009--A 35 year old woman with fever, abdominal pain, and hypotension after Cesarean section. New England Journal of Medicine. 2009; 361(17):1689-1697.de Moya, Marc A., del Carmen, Marcela G., Allain Rae M., Hirschberg, Ronald E., Shepard, Jo-Anne O., and Kradin, Richard L. New England Journal of Medicine2009361(17):1689-1697http://www.ncbi.nlm.nih.gov/pubmed/19846855Case records of the Massachusetts General Hospital. Case 33-2009. A 35-year-old woman with fever, abdominal pain, and hypotension after cesarean section. N Engl J Med. 2009 Oct 22; 361(17):1689-97.de Moya MA, del Carmen MG, Allain RM, Hirschberg RE, Shepard JA, Kradin RL. N Engl J Med2009 Oct 22361(17):1689-97http://www.ncbi.nlm.nih.gov/pubmed/18922432Fatal heparin-induced thrombocytopenia 8 months after prior exposure to heparin. J Cardiothorac Vasc Anesth. 2008 Oct; 22(5):732-4.Crimi C, Berra L, Kalra A, Allain R, Cambria RP. J Cardiothorac Vasc Anesth2008 Oct22(5):732-4Transfusion Therapy and Anticoagulation. Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital. 2006.Allain R., Pino R. . Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital2006Ethical and End-of-Life Issues. Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital. 2006.Allain R., Brackett S., Hurford W. . Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital2006Vascular Surgery. Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital. 2006.Wesner L., Allain R. Bigatello L., Ed. Critical Care Handbook of the Massachusetts General Hospital2006Critical Care Handbook of the Massachusetts General Hospital. 2006.Allain, R., Associate Editor. Bigatello L., Senior Editor. . Critical Care Handbook of the Massachusetts General Hospital2006http://www.ncbi.nlm.nih.gov/pubmed/15632515Carotid endarterectomy. Int Anesthesiol Clin. 2005; 43(1):15-38.Allain R, Marone LK, Meltzer J, Jeyabalan G. Int Anesthesiol Clin200543(1):15-38http://www.ncbi.nlm.nih.gov/pubmed/15173690Acute lung injury after pulmonary resection. Minerva Anestesiol. 2004 Apr; 70(4):159-66.Bigatello LM, Allain R, Gaissert HA. Minerva Anestesiol2004 Apr70(4):159-66Liver Transplantation. Yao R., ed. Yao & Artusio's Anesthesiology: Problem-Oriented Patient Management. 2003.Peterfreund RA, Allain RM. . Yao R., ed. Yao & Artusio's Anesthesiology: Problem-Oriented Patient Management2003Ethical and End of Life Decisions. Hurford W., ed. Postoperative Critical Care of the Massachusetts General Hospital. 2000.Allain R., Hurford W. . Hurford W., ed. Postoperative Critical Care of the Massachusetts General Hospital2000Preoperative Evaluation of the Patient with Hepatobiliary Disease. Sweitzer B., ed. Handbook of Preoperative Assessment and Management. 2000.Allain R. Sweitzer B., ed. Handbook of Preoperative Assessment and Management2000Hematology and Transfusion Therapy. Hurford W., ed. Postoperative Critical Care of the Massachusetts General Hospital. 2000.Allain R., Pino R. . Hurford W., ed. Postoperative Critical Care of the Massachusetts General Hospital2000Respiratory Therapy and Critical Care. Dershwitz M., ed. The MGH Board Review of Anesthesiology. 1998.Allain R. . Dershwitz M., ed. The MGH Board Review of Anesthesiology1998Transfusion Therapy. Hurford W., Davison J., eds. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 1997.Hansell D., Allain R. . Hurford W., Davison J., eds. Clinical Anesthesia Procedures of the Massachusetts General Hospital1997Endarterectomy, Carotid24.782601578848964e-0012005-01-01T00:00:002016-01-01T00:00:00Carotid Stenosis24.162072472622582e-0012005-01-01T00:00:002016-01-01T00:00:00Anesthesia12.210421040917439e-0012016-01-01T00:00:002016-01-01T00:00:00Stents12.019470068016643e-0012016-01-01T00:00:002016-01-01T00:00:00Anesthesia, Conduction11.784274787279646e-0012005-01-01T00:00:002005-01-01T00:00:00Endovascular Procedures11.696754225113111e-0012016-01-01T00:00:002016-01-01T00:00:00Ultrasonography, Doppler, Transcranial21.540762549756699e-0012005-01-01T00:00:002016-01-01T00:00:00Carotid Artery Diseases11.425665974716997e-0012005-01-01T00:00:002005-01-01T00:00:00Anesthesia, General11.324850699524447e-0012005-01-01T00:00:002005-01-01T00:00:00Critical Care Nursing19.881609762810216e-0022014-07-10T00:00:002014-07-10T00:00:00Professional-Family Relations17.897788451903924e-0022014-07-10T00:00:002014-07-10T00:00:00Abdomen, Acute17.383197599280555e-0022009-10-22T00:00:002009-10-22T00:00:00Fasciitis, Necrotizing17.346174985429695e-0022009-10-22T00:00:002009-10-22T00:00:00Monitoring, Physiologic17.003140744771348e-0022016-01-01T00:00:002016-01-01T00:00:00Informed Consent16.718082069716816e-0022014-07-10T00:00:002014-07-10T00:00:00Streptococcus pyogenes16.562429403080830e-0022009-10-22T00:00:002009-10-22T00:00:00Cerebrovascular Circulation15.791560978333663e-0022016-01-01T00:00:002016-01-01T00:00:00Electroencephalography25.769189606325371e-0022005-01-01T00:00:002016-01-01T00:00:00Extremities15.258251871333158e-0022009-10-22T00:00:002009-10-22T00:00:00Family15.006105978080117e-0022014-07-10T00:00:002014-07-10T00:00:00Shock, Septic14.826518496626368e-0022009-10-22T00:00:002009-10-22T00:00:00Neurologic Examination14.421844104771159e-0022005-01-01T00:00:002005-01-01T00:00:00Critical Care14.332526970741182e-0022014-07-10T00:00:002014-07-10T00:00:00Cesarean Section14.293581258853372e-0022009-10-22T00:00:002009-10-22T00:00:00Intraoperative Care14.176580605468833e-0022005-01-01T00:00:002005-01-01T00:00:00Heparin14.090687868146464e-0022008-01-11T00:00:002008-01-11T00:00:00Thrombocytopenia13.887810813579497e-0022008-01-11T00:00:002008-01-11T00:00:00Communication13.755927053461657e-0022014-07-10T00:00:002014-07-10T00:00:00Postoperative Complications33.683029060549584e-0022004-04-01T00:00:002009-10-22T00:00:00Monitoring, Intraoperative13.521548964205629e-0022005-01-01T00:00:002005-01-01T00:00:00Postoperative Care13.436546728557816e-0022005-01-01T00:00:002005-01-01T00:00:00Pneumonectomy13.213434555320933e-0022004-04-01T00:00:002004-04-01T00:00:00Preoperative Care12.807013653910715e-0022005-01-01T00:00:002005-01-01T00:00:00Lung Diseases12.563346024395024e-0022004-04-01T00:00:002004-04-01T00:00:00Anticoagulants12.264146366747806e-0022008-01-11T00:00:002008-01-11T00:00:00Diagnostic Imaging12.049588525986479e-0022005-01-01T00:00:002005-01-01T00:00:00Coronary Disease12.046187673244882e-0022005-01-01T00:00:002005-01-01T00:00:00Comorbidity12.013453419248320e-0022005-01-01T00:00:002005-01-01T00:00:00Gangrene11.917772437910837e-0022009-10-22T00:00:002009-10-22T00:00:00Tachycardia11.642665889323514e-0022009-10-22T00:00:002009-10-22T00:00:00Debridement11.585061266382655e-0022009-10-22T00:00:002009-10-22T00:00:00Foot11.428746927463962e-0022009-10-22T00:00:002009-10-22T00:00:00Necrosis11.420763553861621e-0022009-10-22T00:00:002009-10-22T00:00:00Hand11.289419671723027e-0022009-10-22T00:00:002009-10-22T00:00:00Hypotension11.267170821943746e-0022009-10-22T00:00:002009-10-22T00:00:00Fatal Outcome11.233556522810821e-0022008-01-11T00:00:002008-01-11T00:00:00Amputation, Surgical11.210579956779005e-0022009-10-22T00:00:002009-10-22T00:00:00Stroke11.180525611018428e-0022005-01-01T00:00:002005-01-01T00:00:00Fever11.135854386458583e-0022009-10-22T00:00:002009-10-22T00:00:00Humans61.117361844903499e-0022004-04-01T00:00:002016-01-01T00:00:00Intensive Care Units11.039419477287019e-0022014-07-10T00:00:002014-07-10T00:00:00Intestines11.010435439085554e-0022009-10-22T00:00:002009-10-22T00:00:00Radiography19.017763604180466e-0032009-10-22T00:00:002009-10-22T00:00:00Risk Factors18.236985223397733e-0032005-01-01T00:00:002005-01-01T00:00:00Diagnosis, Differential16.700860847302498e-0032009-10-22T00:00:002009-10-22T00:00:00Prospective Studies14.769384585839194e-0032014-07-10T00:00:002014-07-10T00:00:00Female34.053517752179831e-0032008-01-11T00:00:002014-07-10T00:00:00Time Factors13.745855539132994e-0032008-01-11T00:00:002008-01-11T00:00:00Middle Aged12.333919348246946e-0032014-07-10T00:00:002014-07-10T00:00:00Male11.815667672269743e-0032014-07-10T00:00:002014-07-10T00:00:00Adult11.683417290371379e-0032009-10-22T00:00:002009-10-22T00:00:00Aged11.662404518578379e-0032008-01-11T00:00:002008-01-11T00:00:00Benjamin Allar, M.D.BenjaminAllar

Beth Israel Deaconess Medical CenterSuite 9B110 Francis StreetBoston, MA 02215617/632-9236

1BIDMCBeth Israel Deaconess Medical CenterSurgeryGeneral SurgeryClinical Fellow in SurgeryFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=105445473https://csph.brighamandwomens.org/?team=benjamin-allar1https://twitter.com/BenAllarMD2Tufts University School of MedicineBoston, MAMD2018Harvard T.H. Chan School of Public HealthBoston, MAMPH2022Clinical Effectivenesshttp://www.ncbi.nlm.nih.gov/pubmed/41676994Complications and Readmissions in Diverting Loop Ileostomies and Loop Colostomies. Dis Colon Rectum. 2026 Feb 12.Arndt KR, Papadimatos S, Allar BG, Kim K, Wong DJ, Crowell KT, Cataldo TE, Messaris E. Dis Colon Rectum2026 Feb 12http://www.ncbi.nlm.nih.gov/pubmed/40939544Understanding beyond words: The impact of English proficiency in postoperative outcomes after solid organ transplantation. Am J Surg. 2025 Dec; 250:116604.Canizares S, Chumdermpadetsuk R, Allar BG, Rivera M, Modest A, Dib M, Devin E. Am J Surg2025 Dec250:116604http://www.ncbi.nlm.nih.gov/pubmed/40234359Prostate Cancer Screening Among Traditionally Underserved Populations at a Large Public Safety-Net Institution. J Gen Intern Med. 2025 Apr 15.Zurl H, Dagnino F, Shabo M, Mahmood R, Allar BG, Gershman B, Weissman L, Ortega G, Hastings S, Rayala HJ. J Gen Intern Med2025 Apr 15http://www.ncbi.nlm.nih.gov/pubmed/40131762Language Serving Hospitals and their Impact on Readmission for Surgical Patients with a Non-English Primary Language: A Retrospective Cohort Study. Ann Surg. 2025 Mar 25.Dacier BM, Jones AN, Allar BG, Mejia J, Torres BS, Murphy RE, Magana N, Bergmark RW, Pusic AL, Fernandez A, Bates DW, Peck GL, Ortega G. Ann Surg2025 Mar 25http://www.ncbi.nlm.nih.gov/pubmed/39977591Research Perspective on Effectiveness of Organ Preservation for Locally Advanced Rectal Cancer With Complete Clinical Response After Neoadjuvant Chemoradiotherapy: Bayesian Network Meta-analysis. Dis Colon Rectum. 2025 Mar 01; 68(3):299.Allar BG. Dis Colon Rectum2025 Mar 0168(3):299http://www.ncbi.nlm.nih.gov/pubmed/39303651Interaction of Insurance and Neighborhood Income on Operative Colorectal Cancer Outcomes Within a National Database. J Surg Res. 2024 Nov; 303:95-104.Allar BG, Abraham L, Eruchalu CN, Rahimi A, Dey T, Peck GL, Kwakye G, Loehrer AP, Crowell KT, Messaris E, Bergmark RW, Ortega G. J Surg Res2024 Nov303:95-104http://www.ncbi.nlm.nih.gov/pubmed/39088781Factors Affecting Colorectal Cancer Screening in Primary Care Physician Practices in Ukraine. JCO Glob Oncol. 2024 Aug; 10:e2400053.Dzhemiliev A, Kizub D, Wanis KN, Allar BG, Vus V, Malovanna A, Huivaniuk I, Kopetskyi V, Beznosenko A, Shabat G, Antoniv M, Suprun U, Melnitchouk N. JCO Glob Oncol2024 Aug10:e2400053http://www.ncbi.nlm.nih.gov/pubmed/38921829A Randomized Crossover Trial Evaluating the Impact of Cultural Dexterity Training on Surgical Residents' Knowledge, Cross-Cultural Care, Skills, and Beliefs: The Provider Awareness and Cultural Dexterity Training for Surgeons (PACTS) Trial. Ann Surg. 2024 Sep 01; 280(3):403-413.Smink DS, Ortega G, Dacier BM, Petrusa ER, Chen YJ, Shaikh NQ, Allar BG, Chun MBJ, Green AR, Caldwell KE, Atkinson RB, Reidy E, Olufajo OA, Britt LD, Brittain MA, Zárate Rodriguez J, Swoboda SM, Cornwell EE, Lynch KA, Wise PE, Harrington DT, Kent TS, Mullen JT, Lipsett PA, Haider AH. Ann Surg2024 Sep 01280(3):403-413http://www.ncbi.nlm.nih.gov/pubmed/38531750Teaching cultural dexterity in surgical care: As essential to a surgeon's skill set as tying a knot. Am J Surg. 2024 Nov; 237:115705.Ortega G, Dacier BM, Zárate Rodriguez J, Chun MBJ, Udyavar NR, Allar BG, Green AR, Haider AH, Smink DS. Am J Surg2024 Nov237:115705http://www.ncbi.nlm.nih.gov/pubmed/38393458Mental health disorders as a risk factor in young patients with rectal prolapse. Langenbecks Arch Surg. 2024 Feb 23; 409(1):72.Whitlock AE, Arndt KR, Allar BG, Fakler MN, Cataldo TE, Crowell KT, Fabrizio AC, Messaris E. Langenbecks Arch Surg2024 Feb 23409(1):72http://www.ncbi.nlm.nih.gov/pubmed/38142149Changing Surgical Culture Through Surgical Education: Introduction to the PACTS Trial. J Surg Educ. 2024 03; 81(3):330-334.Allar BG, Ortega G, Chun MBJ, Rodriguez JGZ, Mullen JT, Lynch KA, Harrington DT, Green AR, Lipsett PA, Britt LD, Haider AH, Smink DS, Kent TS. J Surg Educ2024 0381(3):330-334http://www.ncbi.nlm.nih.gov/pubmed/37990875A Conduit for a Culturally Competent Consent: Medical Interpreters' Perspectives on Surgical Informed Consent Discussions. Ann Surg. 2024 Jul 01; 280(1):66-74.Allar BG, Ponce C, Wallace J, Ortega G, Reich AJ, Gold-Gomez S, Gangadharan SP, Kent TS. Ann Surg2024 Jul 01280(1):66-74http://www.ncbi.nlm.nih.gov/pubmed/37844709Unique Breast Cancer Screening Disparities in a Safety-Net Health System. Am J Prev Med. 2024 03; 66(3):473-482.Allar BG, Torres M, Mahmood R, Ortega G, Himmelstein J, Weissmann L, Sheth K, Rayala HJ. Am J Prev Med2024 0366(3):473-482http://www.ncbi.nlm.nih.gov/pubmed/37379025A Step Toward Language Equity Using Clinical Trials. JAMA Surg. 2023 09 01; 158(9):909.Peck GL, Allar BG, Ortega G. JAMA Surg2023 09 01158(9):909http://www.ncbi.nlm.nih.gov/pubmed/37036567Early C-reactive protein after colorectal surgery is not predictive of anastomotic leak: a retrospective cohort study. Langenbecks Arch Surg. 2023 Apr 10; 408(1):142.Raje P, Allar BG, Arndt KR, Crowell KT, Messaris E. Langenbecks Arch Surg2023 Apr 10408(1):142http://www.ncbi.nlm.nih.gov/pubmed/36898906Impact of National Accreditation Program for Rectal Cancer guidelines on surgical margin status. Surg Oncol. 2023 Dec; 51:101921.Arndt KR, Dombek GE, Allar BG, Storino A, Fleishman A, Quinn J, Fabrizio A, Cataldo TE, Messaris E. Surg Oncol2023 Dec51:101921http://www.ncbi.nlm.nih.gov/pubmed/36529404Colorectal cancer screening in a safety-net health system: The intersectional impact of race, ethnicity, language, and mental health. Prev Med. 2023 01; 166:107389.Allar BG, Mahmood R, Ortega G, Joseph T, Libaridian LN, Messaris E, Sheth K, Rayala HJ. Prev Med2023 01166:107389http://www.ncbi.nlm.nih.gov/pubmed/36332306Thromboprophylaxis Timing After Blunt Solid Organ Injury: A Systematic Review and Meta-analysis. J Surg Res. 2023 02; 282:270-279.Anteby R, Allar BG, Broekhuis JM, Patel PB, Marcaccio CL, Papageorge MV, Papatheodorou S, Mendoza AE. J Surg Res2023 02282:270-279http://www.ncbi.nlm.nih.gov/pubmed/36302697Trauma patients with limited English proficiency: Outcomes from two level one trauma centers. Am J Surg. 2023 04; 225(4):769-774.Maurer LR, Eruchalu CN, Gaitanidis A, El Hechi M, Allar BG, EdM AR, Salim A, Velmahos GC, Perez NP, de Crescenzo C, Mendoza AE, Dey T, Kaafarani HM, Ortega G. Am J Surg2023 04225(4):769-774http://www.ncbi.nlm.nih.gov/pubmed/36044675Trends in the Management of Non-emergent Surgery for Diverticular Disease and the Impact of Practice Parameters. Am Surg. 2023 Nov; 89(11):4590-4597.Ore AS, Allar BG, Fabrizio A, Cataldo TE, Messaris E. Am Surg2023 Nov89(11):4590-4597http://www.ncbi.nlm.nih.gov/pubmed/35339269Lost in translation: A qualitative analysis of facilitators and barriers to collecting patient reported outcome measures for surgical patients with limited English proficiency. Am J Surg. 2022 07; 224(1 Pt B):514-521.Allar BG, Eruchalu CN, Rahman S, Mou D, Ortega G, Reich AJ, Pusic AL, Brook CD, Sisodia RC, Bergmark RW. Am J Surg2022 07224(1 Pt B):514-521http://www.ncbi.nlm.nih.gov/pubmed/34387209Prioritizing Health Equity in Patient-reported Outcome Measurement to Improve Surgical Care. Ann Surg. 2022 03 01; 275(3):488-491.Ortega G, Allar BG, Kaur MN, Edelen MO, Witt EE, Fayanju OM, Telem DA, Wagman LD, Sisodia RC, Powe NR, Pusic AL. Ann Surg2022 03 01275(3):488-491http://www.ncbi.nlm.nih.gov/pubmed/35185128Association between Surgery, Anesthesia, and Obstetric Workforce and Emergent Surgical and Obstetric Mortality among United States Hospital Referral Regions. Ann Surg. 2023 06 01; 277(6):952-957.Truche P, Semco RS, Hansen NF, Uribe-Leitz T, Roa L, Allar BG, Layman IB, Bergmark RW, Williams W, Riviello R, McClain CD, Jarman MP, Cooper Z, Meara JG, Ortega G. Ann Surg2023 06 01277(6):952-957http://www.ncbi.nlm.nih.gov/pubmed/35150339Oncotype DX testing does not affect clinical practice in stage IIa colon cancer. Med Oncol. 2022 Feb 12; 39(5):59.Allar BG, Messaris E, Poylin VY, Schlechter BL, Cataldo TE. Med Oncol2022 Feb 1239(5):59http://www.ncbi.nlm.nih.gov/pubmed/35104065Speaking the Same Language: Improving Language-concordant Care in Surgery. Ann Surg. 2022 05 01; 275(5):e671-e672.Ruiz AM, Allar BG, Fernandez A, Bates DW, Ortega G. Ann Surg2022 05 01275(5):e671-e672http://www.ncbi.nlm.nih.gov/pubmed/34474213Non-English Primary Language is Associated with Emergency Surgery for Diverticulitis. J Surg Res. 2021 12; 268:643-649.Maurer LR, Allar BG, Perez NP, Witt EE, Uribe-Leitz T, Peck GL, Bergmark RW, Bates DW, Ortega G. J Surg Res2021 12268:643-649http://www.ncbi.nlm.nih.gov/pubmed/34049306Sclerotherapy for Aneurysmal Bone Cysts: Scale for Response. J Pediatr Orthop. 2021 Aug 01; 41(7):444-449.Ramkumar DB, Ercolano LB, Allar BG, Miller PE, Padua H, Anderson ME. J Pediatr Orthop2021 Aug 0141(7):444-449http://www.ncbi.nlm.nih.gov/pubmed/34344640Palliative Care Education for Surgical Residents: Current Practices and Future Directions. J Surg Educ. 2022 Jan-Feb; 79(1):3-7.Allar BG, Weinstock J, Buss MK, Kent TS. J Surg Educ2022 Jan-Feb79(1):3-7http://www.ncbi.nlm.nih.gov/pubmed/34258672Language Proficiency and Survival in Pancreatic Cancer: a Propensity Score-Matched Analysis. J Gastrointest Surg. 2022 01; 26(1):94-103.Calvillo-Ortiz R, Polanco-Santana JC, Castillo-Angeles M, Allar BG, Anguiano-Landa L, Ghaffarpasand E, Barrows C, Callery MP, Kent TS. J Gastrointest Surg2022 0126(1):94-103http://www.ncbi.nlm.nih.gov/pubmed/34182025Preoperative statin therapy is associated with higher 5-year survival after thoracic endovascular aortic repair. J Vasc Surg. 2021 12; 74(6):1996-2005.Allar BG, Swerdlow NJ, de Guerre LEVM, Dansey KD, Li C, Wang GJ, Patel VI, Schermerhorn ML. J Vasc Surg2021 1274(6):1996-2005http://www.ncbi.nlm.nih.gov/pubmed/33840445Differences in outcomes after emergency general surgery between Hispanic subgroups in the New Jersey State Inpatient Database (2009-2014): The Hispanic population is not monolithic. Am J Surg. 2021 09; 222(3):492-498.Maurer LR, Rahman S, Perez N, Allar BG, Witt E, Moya J, Pichardo MS, Romero Arenas MA, Uribe-Leitz T, Dey T, Bergmark RW, Peck G, Ortega G. Am J Surg2021 09222(3):492-498http://www.ncbi.nlm.nih.gov/pubmed/33812806Paging Patterns Among Junior Surgery Residents in a Tertiary Care Center. J Surg Educ. 2021 Sep-Oct; 78(5):1483-1491.Storino A, Polanco-Santana JC, Allar BG, Fakler MN, Wong D, Whyte R, Gangadharan SP, Kent TS. J Surg Educ2021 Sep-Oct78(5):1483-1491http://www.ncbi.nlm.nih.gov/pubmed/33315709Bibliometric Analysis of Five Major Colorectal Surgery Categories: Surpluses and Shortages. Dis Colon Rectum. 2021 02 01; 64(2):147-150.Allar BG, Ore AS, Fabrizio AC, Messaris E, Cataldo TE. Dis Colon Rectum2021 02 0164(2):147-150http://www.ncbi.nlm.nih.gov/pubmed/33282365Time to surgery in thoracic cancers and prioritization during COVID-19: a systematic review. J Thorac Dis. 2020 Nov; 12(11):6640-6654.Fligor SC, Tsikis ST, Wang S, Ore AS, Allar BG, Whitlock AE, Calvillo-Ortiz R, Arndt K, Callery MP, Gangadharan SP. J Thorac Dis2020 Nov12(11):6640-6654http://www.ncbi.nlm.nih.gov/pubmed/33096588Pausing for the pandemic? The impact of deferring breast cancer surgery. Breast J. 2020 12; 26(12):2437-2438.Whitlock AE, Allar BG, James T. Breast J2020 1226(12):2437-2438http://www.ncbi.nlm.nih.gov/pubmed/32754903Oropharyngeal psychogenic purpura. Br J Haematol. 2020 12; 191(5):651.Allar BG, Michaelsen K, Gupta A, Bose S. Br J Haematol2020 12191(5):651http://www.ncbi.nlm.nih.gov/pubmed/32607860Gastrointestinal Malignancies and the COVID-19 Pandemic: Evidence-Based Triage to Surgery. J Gastrointest Surg. 2020 10; 24(10):2357-2373.Fligor SC, Wang S, Allar BG, Tsikis ST, Ore AS, Whitlock AE, Calvillo-Ortiz R, Arndt KR, Gangadharan SP, Callery MP. J Gastrointest Surg2020 1024(10):2357-2373http://www.ncbi.nlm.nih.gov/pubmed/32001122ST Segment Elevation Caused by Artifact From Cylindrical Battery Ingestion. J Emerg Med. 2020 Apr; 58(4):673-676.Ordoobadi AJ, Allar BG, Orhurhu V, Keith S, Cocchi MN. J Emerg Med2020 Apr58(4):673-676http://www.ncbi.nlm.nih.gov/pubmed/30130519Measuring the Reliability and Construct Validity of the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT) in Children With Cerebral Palsy. Arch Phys Med Rehabil. 2019 01; 100(1):45-51.Shore BJ, Allar BG, Miller PE, Matheney TH, Snyder BD, Fragala-Pinkham M. Arch Phys Med Rehabil2019 01100(1):45-51http://www.ncbi.nlm.nih.gov/pubmed/28379484Evaluating the Discriminant Validity of the Pediatric Evaluation of Disability Inventory: Computer Adaptive Test in Children With Cerebral Palsy. Phys Ther. 2017 Jun 01; 97(6):669-676.Shore BJ, Allar BG, Miller PE, Matheney TH, Snyder BD, Fragala-Pinkham MA. Phys Ther2017 Jun 0197(6):669-676http://www.ncbi.nlm.nih.gov/pubmed/27135220Treatment outcomes after insufficiency femoral diaphyseal fractures in nonambulatory children. J Pediatr Orthop B. 2016 Jul; 25(4):331-7.Allar BG, Hedequist DJ, Miller PE, Glotzbecker MP, Spencer SA, Shore BJ. J Pediatr Orthop B2016 Jul25(4):331-7http://www.ncbi.nlm.nih.gov/pubmed/27111078Ipsilateral Nonvascularized Autograft and Periosteal Repair for the Treatment of Pediatric Tumors of the Distal Fibula. Orthopedics. 2016 Jul 01; 39(4):e687-94.Yeung CM, Lozano-Calderón SA, Allar B, Naqvi M, Gebhardt MC, Anderson ME. Orthopedics2016 Jul 0139(4):e687-94Limited English Proficiency39.473877111171456e-0012022-03-10T00:00:002025-09-02T00:00:00Cultural Competency37.341963672629759e-0012023-11-22T00:00:002024-06-26T00:00:00Translating17.231558616738496e-0012023-11-22T00:00:002023-11-22T00:00:00Factitious Disorders16.519957594457378e-0012020-08-04T00:00:002020-08-04T00:00:00Skin Diseases, Vascular16.422750920575369e-0012020-08-04T00:00:002020-08-04T00:00:00Language85.819066360086882e-0012018-08-18T00:00:002023-10-14T00:00:00Psychophysiologic Disorders15.786743086827143e-0012020-08-04T00:00:002020-08-04T00:00:00Colorectal Surgery15.785711612817411e-0012021-02-01T00:00:002021-02-01T00:00:00Informed Consent15.144439372124243e-0012023-11-22T00:00:002023-11-22T00:00:00Bibliometrics15.103010158180705e-0012021-02-01T00:00:002021-02-01T00:00:00Income14.647896983971772e-0012024-09-19T00:00:002024-09-19T00:00:00Internship and Residency44.592159096692235e-0012021-03-31T00:00:002024-06-26T00:00:00Aortic Diseases14.535434781231563e-0012021-06-26T00:00:002021-06-26T00:00:00Colorectal Neoplasms34.478607374777502e-0012022-12-15T00:00:002024-09-19T00:00:00Aorta, Thoracic14.342450397006913e-0012021-06-26T00:00:002021-06-26T00:00:00Fracture Fixation, Intramedullary14.308869267689868e-0012016-07-01T00:00:002016-07-01T00:00:00Surgeons24.198955594629372e-0012022-02-17T00:00:002023-12-23T00:00:00Fracture Fixation14.073295651272151e-0012016-07-01T00:00:002016-07-01T00:00:00Communication Barriers44.043420018491211e-0012021-07-13T00:00:002025-09-02T00:00:00Physician-Patient Relations23.892240894955885e-0012021-09-15T00:00:002023-11-22T00:00:00Bone Plates13.816771445739102e-0012016-07-01T00:00:002016-07-01T00:00:00Femoral Fractures13.639933095771432e-0012016-07-01T00:00:002016-07-01T00:00:00Blood Vessel Prosthesis Implantation13.395139765801116e-0012021-06-26T00:00:002021-06-26T00:00:00Colonic Neoplasms13.142975912695913e-0012022-02-12T00:00:002022-02-12T00:00:00Autoimmune Diseases12.767165288854395e-0012020-08-04T00:00:002020-08-04T00:00:00Ethnicity12.617510253894265e-0012022-12-15T00:00:002022-12-15T00:00:00Endovascular Procedures12.481425460630191e-0012021-06-26T00:00:002021-06-26T00:00:00Surgical Procedures, Operative32.479922624065469e-0012021-04-02T00:00:002023-11-22T00:00:00Hydroxymethylglutaryl-CoA Reductase Inhibitors12.459008746721454e-0012021-06-26T00:00:002021-06-26T00:00:00Curriculum32.263939927104598e-0012021-08-01T00:00:002024-06-26T00:00:00Medicare12.240280626407123e-0012023-10-14T00:00:002023-10-14T00:00:00Biomedical Research12.232207303861010e-0012021-02-01T00:00:002021-02-01T00:00:00Neoplasm Recurrence, Local32.159621747576705e-0012016-04-27T00:00:002023-03-02T00:00:00Psychotic Disorders12.157215913794684e-0012020-08-04T00:00:002020-08-04T00:00:00General Surgery32.125248744894045e-0012021-04-02T00:00:002024-06-26T00:00:00Early Detection of Cancer32.089412401027374e-0012022-12-15T00:00:002024-08-01T00:00:00Rectal Prolapse12.037086801335874e-0012024-02-23T00:00:002024-02-23T00:00:00Colectomy31.922761602762345e-0012021-08-30T00:00:002023-04-10T00:00:00Diverticular Diseases11.850445424059107e-0012022-08-31T00:00:002022-08-31T00:00:00Disability Evaluation31.828976698855711e-0012016-04-27T00:00:002018-08-18T00:00:00Linear Models21.775959953202019e-0012021-02-01T00:00:002022-02-12T00:00:00Haiti11.771557259311962e-0012023-10-14T00:00:002023-10-14T00:00:00Anastomotic Leak11.731150752807155e-0012023-04-10T00:00:002023-04-10T00:00:00Diverticulitis, Colonic11.694483371588580e-0012022-08-31T00:00:002022-08-31T00:00:00Fecal Incontinence11.673736059897131e-0012024-02-23T00:00:002024-02-23T00:00:00Clinical Competence31.513897444034140e-0012023-12-23T00:00:002024-06-26T00:00:00Margins of Excision11.510734665401221e-0012023-03-02T00:00:002023-03-02T00:00:00Abdominal Injuries11.506441095360529e-0012022-11-01T00:00:002022-11-01T00:00:00Patient Reported Outcome Measures21.467196458989219e-0012022-03-01T00:00:002022-03-10T00:00:00Humans361.463444163142659e-0012016-04-27T00:00:002025-09-02T00:00:00Medically Uninsured11.462036243724847e-0012024-09-19T00:00:002024-09-19T00:00:00Breast Neoplasms21.456135627174636e-0012020-10-23T00:00:002023-10-14T00:00:00Diverticulitis11.428824898819555e-0012021-08-30T00:00:002021-08-30T00:00:00Retrospective Studies131.426258199250578e-0012016-04-27T00:00:002025-09-02T00:00:00Protective Factors11.425519240330925e-0012021-06-26T00:00:002021-06-26T00:00:00Cross-Over Studies11.360035913061842e-0012024-06-26T00:00:002024-06-26T00:00:00Multicenter Studies as Topic11.359533390841930e-0012023-12-23T00:00:002023-12-23T00:00:00Physicians, Primary Care11.340548419559918e-0012024-08-01T00:00:002024-08-01T00:00:00Emergency Treatment11.333032693710700e-0012021-04-02T00:00:002021-04-02T00:00:00Clinical Trials as Topic21.311256886051845e-0012023-09-01T00:00:002023-12-23T00:00:00Healthcare Disparities21.291022521099893e-0012023-10-14T00:00:002024-09-19T00:00:00Postoperative Complications31.238456877527801e-0012021-06-26T00:00:002025-09-02T00:00:00Cerebral Palsy21.217975836568569e-0012017-06-01T00:00:002018-08-18T00:00:00Middle Aged111.194180338476905e-0012020-01-27T00:00:002025-09-02T00:00:00Wounds, Nonpenetrating11.191703920055732e-0012022-11-01T00:00:002022-11-01T00:00:00Patients11.170211309059359e-0012022-03-10T00:00:002022-03-10T00:00:00Interviews as Topic11.151616721513726e-0012023-11-22T00:00:002023-11-22T00:00:00Organ Transplantation11.128409553697187e-0012025-09-02T00:00:002025-09-02T00:00:00Female181.121394166998730e-0012016-04-27T00:00:002025-09-02T00:00:00Bone Nails11.095494665144915e-0012016-07-01T00:00:002016-07-01T00:00:00Children with Disabilities11.079911279297179e-0012017-06-01T00:00:002017-06-01T00:00:00ST Elevation Myocardial Infarction11.077477809005945e-0012020-01-27T00:00:002020-01-27T00:00:00Education, Medical, Graduate21.074163928930956e-0012023-12-23T00:00:002024-06-26T00:00:00Elasticity11.059478703831245e-0012016-07-01T00:00:002016-07-01T00:00:00Residence Characteristics11.048973523761017e-0012024-09-19T00:00:002024-09-19T00:00:00Rectal Neoplasms11.036459140415614e-0012023-03-02T00:00:002023-03-02T00:00:00Databases, Factual31.026412462067185e-0012021-04-02T00:00:002024-09-19T00:00:00Fibula11.021699906239357e-0012016-04-27T00:00:002016-04-27T00:00:00Male151.012511948834253e-0012016-04-27T00:00:002025-09-02T00:00:00Chemotherapy, Adjuvant19.974314557348409e-0022022-02-12T00:00:002022-02-12T00:00:00Triage19.718047248381688e-0022020-06-30T00:00:002020-06-30T00:00:00Insurance Coverage19.682412267089510e-0022024-09-19T00:00:002024-09-19T00:00:00Liver Transplantation19.632240527265640e-0022025-09-02T00:00:002025-09-02T00:00:00Health Equity19.505418308090918e-0022022-03-01T00:00:002022-03-01T00:00:00Bone Screws19.415136646937038e-0022016-07-01T00:00:002016-07-01T00:00:00Gastrointestinal Neoplasms19.341281588418184e-0022020-06-30T00:00:002020-06-30T00:00:00Burnout, Professional19.154084998488779e-0022021-03-31T00:00:002021-03-31T00:00:00Insurance, Health19.133597647677408e-0022024-09-19T00:00:002024-09-19T00:00:00Multivariate Analysis29.017931365325660e-0022021-04-02T00:00:002022-02-12T00:00:00Anesthesiology18.930510813614759e-0022022-02-17T00:00:002022-02-17T00:00:00Qualitative Research18.798422813823742e-0022023-11-22T00:00:002023-11-22T00:00:00Hispanic or Latino28.581046694946784e-0022021-04-02T00:00:002021-09-15T00:00:00C-Reactive Protein18.576885712794284e-0022023-04-10T00:00:002023-04-10T00:00:00Anesthesia18.451773392014116e-0022022-02-17T00:00:002022-02-17T00:00:00Mental Health28.408911711741215e-0022022-12-15T00:00:002024-02-23T00:00:00Medicaid18.350721985650575e-0022024-09-19T00:00:002024-09-19T00:00:00Aged68.232777910691425e-0022021-04-02T00:00:002024-02-23T00:00:00Hospital Mortality18.190817688646108e-0022024-09-19T00:00:002024-09-19T00:00:00Neoplasm Staging28.139763808183723e-0022022-02-12T00:00:002023-03-02T00:00:00Risk Assessment27.900618584782666e-0022021-06-26T00:00:002022-02-12T00:00:00Femur17.830059521944406e-0022016-07-01T00:00:002016-07-01T00:00:00Kidney Transplantation17.813802536071751e-0022025-09-02T00:00:002025-09-02T00:00:00Elective Surgical Procedures37.462966270556426e-0022020-06-30T00:00:002022-08-31T00:00:00Venous Thromboembolism17.444763779479874e-0022022-11-01T00:00:002022-11-01T00:00:00United States47.171371191209078e-0022022-02-17T00:00:002024-09-19T00:00:00Betacoronavirus16.434595391957720e-0022020-06-30T00:00:002020-06-30T00:00:00Adult96.431846392076880e-0022021-04-02T00:00:002025-09-02T00:00:00Risk Factors36.055483694553790e-0022021-06-26T00:00:002024-02-23T00:00:00Aged, 80 and over25.891572583767558e-0022021-06-26T00:00:002022-02-12T00:00:00Palliative Care15.886389664405144e-0022021-08-01T00:00:002021-08-01T00:00:00Gene Expression Profiling15.868281484947946e-0022022-02-12T00:00:002022-02-12T00:00:00Treatment Outcome45.757645890848707e-0022016-04-27T00:00:002024-02-23T00:00:00Patient Readmission35.467289405530229e-0022021-04-02T00:00:002025-09-02T00:00:00Registries15.426410045079454e-0022021-06-26T00:00:002021-06-26T00:00:00Electronic Health Records15.146023714016462e-0022022-03-10T00:00:002022-03-10T00:00:00Ukraine15.125337249917686e-0022024-08-01T00:00:002024-08-01T00:00:00Bone Neoplasms14.994682639598352e-0022016-04-27T00:00:002016-04-27T00:00:00Occult Blood14.981403385747486e-0022024-08-01T00:00:002024-08-01T00:00:00Surveys and Questionnaires24.969033368179648e-0022021-08-01T00:00:002024-08-01T00:00:00Pancreatic Neoplasms14.897349791991282e-0022021-07-13T00:00:002021-07-13T00:00:00Coronavirus Infections14.870657605357532e-0022020-06-30T00:00:002020-06-30T00:00:00Pneumonia, Viral14.820112346994975e-0022020-06-30T00:00:002020-06-30T00:00:00Pediatrics14.734610346854444e-0022018-08-18T00:00:002018-08-18T00:00:00Culturally Competent Care14.596622838712386e-0022024-06-26T00:00:002024-06-26T00:00:00Colon, Sigmoid14.497545707717383e-0022022-08-31T00:00:002022-08-31T00:00:00Cuba14.359799528910245e-0022021-04-02T00:00:002021-04-02T00:00:00Central America14.303508588816506e-0022021-04-02T00:00:002021-04-02T00:00:00Biomarkers, Tumor14.230029696494323e-0022022-02-12T00:00:002022-02-12T00:00:00South America14.196879184843659e-0022021-04-02T00:00:002021-04-02T00:00:00New Jersey14.133333384168090e-0022021-04-02T00:00:002021-04-02T00:00:00Puerto Rico13.858731365493369e-0022021-04-02T00:00:002021-04-02T00:00:00Time Factors13.807966612292735e-0022021-06-26T00:00:002021-06-26T00:00:00Length of Stay23.763826130047178e-0022021-04-02T00:00:002025-09-02T00:00:00Accreditation13.754166143302633e-0022023-03-02T00:00:002023-03-02T00:00:00Myocardial Infarction13.724032271265146e-0022020-01-27T00:00:002020-01-27T00:00:00Antineoplastic Agents13.681991812017264e-0022022-02-12T00:00:002022-02-12T00:00:00Constipation13.652455122678628e-0022024-02-23T00:00:002024-02-23T00:00:00Suture Techniques13.647518516798477e-0022024-03-11T00:00:002024-03-11T00:00:00Activities of Daily Living23.562568899989667e-0022017-06-01T00:00:002018-08-18T00:00:00Mexico13.549760857092642e-0022021-04-02T00:00:002021-04-02T00:00:00Health Priorities13.543397611987478e-0022022-03-01T00:00:002022-03-01T00:00:00Anesthesiologists13.256274513153577e-0022022-02-17T00:00:002022-02-17T00:00:00Discriminant Analysis13.221405349079989e-0022017-06-01T00:00:002017-06-01T00:00:00Workforce13.173532608836180e-0022022-02-17T00:00:002022-02-17T00:00:00Trauma Centers13.151442687159632e-0022022-10-19T00:00:002022-10-19T00:00:00Child43.045628791495251e-0022016-04-27T00:00:002018-08-18T00:00:00Child, Preschool23.015828123032269e-0022016-04-27T00:00:002016-07-01T00:00:00Computers13.015357433850471e-0022018-08-18T00:00:002018-08-18T00:00:00Colonoscopy12.959070703310669e-0022024-08-01T00:00:002024-08-01T00:00:00Periosteum12.875017211503218e-0022016-04-27T00:00:002016-04-27T00:00:00Autografts12.872724835841184e-0022016-04-27T00:00:002016-04-27T00:00:00Tertiary Care Centers12.832679388272262e-0022021-03-31T00:00:002021-03-31T00:00:00Graft Survival12.709278948718738e-0022025-09-02T00:00:002025-09-02T00:00:00Mobility Limitation12.690335692001208e-0022018-08-18T00:00:002018-08-18T00:00:00Infant12.557403393979613e-0022016-07-01T00:00:002016-07-01T00:00:00Prospective Studies42.517262657544915e-0022016-04-27T00:00:002021-03-31T00:00:00COVID-1922.517001534289639e-0022020-06-30T00:00:002020-10-23T00:00:00Eating12.483206516062606e-0022020-01-27T00:00:002020-01-27T00:00:00Self Care12.414033259751624e-0022018-08-18T00:00:002018-08-18T00:00:00Propensity Score12.404107626559841e-0022021-07-13T00:00:002021-07-13T00:00:00Limb Salvage12.328644304650056e-0022016-04-27T00:00:002016-04-27T00:00:00Mastectomy12.325665067656452e-0022020-10-23T00:00:002020-10-23T00:00:00Time-to-Treatment12.325070580097395e-0022020-06-30T00:00:002020-06-30T00:00:00Ankle Joint12.263221527694601e-0022016-04-27T00:00:002016-04-27T00:00:00Graft Rejection12.240150444133310e-0022025-09-02T00:00:002025-09-02T00:00:00Breast12.221066330968317e-0022020-10-23T00:00:002020-10-23T00:00:00Adolescent22.146921389315197e-0022016-07-01T00:00:002018-08-18T00:00:00Artifacts12.141896450475548e-0022020-01-27T00:00:002020-01-27T00:00:00Osteotomy12.105292175291590e-0022016-04-27T00:00:002016-04-27T00:00:00Pandemics22.066421176792991e-0022020-06-30T00:00:002020-10-23T00:00:00Reproducibility of Results21.911197589055910e-0022017-06-01T00:00:002018-08-18T00:00:00Amputation, Surgical11.901361788768495e-0022016-04-27T00:00:002016-04-27T00:00:00Health Knowledge, Attitudes, Practice11.859985812749913e-0022024-06-26T00:00:002024-06-26T00:00:00Mass Screening11.726543564376881e-0022024-08-01T00:00:002024-08-01T00:00:00Patient Selection11.677877375743493e-0022020-06-30T00:00:002020-06-30T00:00:00Primary Health Care11.642134985779391e-0022024-08-01T00:00:002024-08-01T00:00:00Psychometrics11.628723882198347e-0022017-06-01T00:00:002017-06-01T00:00:00Quality of Health Care11.611963726475901e-0022022-03-01T00:00:002022-03-01T00:00:00Practice Patterns, Physicians'11.588103572760541e-0022024-08-01T00:00:002024-08-01T00:00:00Anticoagulants11.579641231684909e-0022022-11-01T00:00:002022-11-01T00:00:00Electrocardiography11.538880700045917e-0022020-01-27T00:00:002020-01-27T00:00:00Cross-Sectional Studies21.505167509252877e-0022017-06-01T00:00:002018-08-18T00:00:00Communication11.496492654039685e-0022021-03-31T00:00:002021-03-31T00:00:00Recovery of Function11.456042888230701e-0022016-04-27T00:00:002016-04-27T00:00:00Plastic Surgery Procedures11.183323866479587e-0022016-04-27T00:00:002016-04-27T00:00:00Biomarkers11.054938708809007e-0022023-04-10T00:00:002023-04-10T00:00:00Pregnancy19.827584578144534e-0032022-02-17T00:00:002022-02-17T00:00:00Cohort Studies18.867684880506512e-0032021-07-13T00:00:002021-07-13T00:00:00SARS-CoV-218.771027280449420e-0032020-06-30T00:00:002020-06-30T00:00:00Quality of Life17.605421648299714e-0032018-08-18T00:00:002018-08-18T00:00:00Nouf K Almaghlouth, M.D.NoufAlmaghlouth

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterPathologyClinical Fellow in PathologyFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=294905804http://www.ncbi.nlm.nih.gov/pubmed/38690577Recurrent joint infection caused by a multidrug-resistant capnophilic Escherichia coli ST131 O25H4 strain. IDCases. 2024; 36:e01976.Nenninger EK, Geffert S, Charla S, Chou C, Uzun EDG, Sawyer D, Badeel R, Chargualaf T, Almaghlouth NK, Hong T. IDCases202436:e01976http://www.ncbi.nlm.nih.gov/pubmed/38166068Escherichia coli Meningitis in a 72-year-old Woman. R I Med J (2013). 2024 Jan 04; 107(1):12-14.Komsani MR, Almaghlouth NK, Charla S, Li J, Mileno MD, Neill MA, Hong T, Lonks JR. R I Med J (2013)2024 Jan 04107(1):12-14http://www.ncbi.nlm.nih.gov/pubmed/37998614Refractory Bilateral Tubo-Ovarian Abscesses in a Patient with Iatrogenic Hypogammaglobulinemia. Diagnostics (Basel). 2023 Nov 19; 13(22).Klein EJ, Almaghlouth NK, Weigel G, Farmakiotis D, Hardy E. Diagnostics (Basel)2023 Nov 1913(22)http://www.ncbi.nlm.nih.gov/pubmed/37984109Using a commercially available assay that measures cytomegalovirus (CMV)-specific T-cell immunity to predict protection against CMV: A prospective, blinded clinical study. Diagn Microbiol Infect Dis. 2024 Feb; 108(2):116139.Almaghlouth NK, Arvanitis P, Vieira K, London A, Farmakiotis D. Diagn Microbiol Infect Dis2024 Feb108(2):116139http://www.ncbi.nlm.nih.gov/pubmed/36780118Outpatient anti-spike monoclonal antibody administration is associated with decreased morbidity and mortality among patients with cancer and COVID-19. Clin Exp Med. 2023 Oct; 23(6):2739-2748.Arvanitis P, Lerner AH, Vieira K, Almaghlouth N, Farmakiotis D. Clin Exp Med2023 Oct23(6):2739-2748http://www.ncbi.nlm.nih.gov/pubmed/36711556Outpatient anti-spike monoclonal antibody administration is associated with decreased morbidity and mortality among patients with cancer and COVID-19. Res Sq. 2023 Jan 09.Arvanitis P, Lerner AH, Vieira K, Almaghlouth N, Farmakiotis D. Res Sq2023 Jan 09http://www.ncbi.nlm.nih.gov/pubmed/34277310The Use of Single Therapy With Tocilizumab Versus Combination Therapy With Remdesivir and Tocilizumab in SARS-CoV-2 Patients in El Paso, Texas. Cureus. 2021 Jul; 13(7):e16351.Almaghlouth NK, Anyiam FE, Shah S, Haq S, Attia MJ, Guevara R, Antony S. Cureus2021 Jul13(7):e16351http://www.ncbi.nlm.nih.gov/pubmed/32986248Risk factors for mortality among patients with SARS-CoV-2 infection: A longitudinal observational study. J Med Virol. 2021 04; 93(4):2021-2028.Almaghlouth NK, Davis MG, Davis MA, Anyiam FE, Guevara R, Antony SJ. J Med Virol2021 0493(4):2021-2028http://www.ncbi.nlm.nih.gov/pubmed/32644254Early use of tocilizumab in the prevention of adult respiratory failure in SARS-CoV-2 infections and the utilization of interleukin-6 levels in the management. J Med Virol. 2021 01; 93(1):491-498.Antony SJ, Davis MA, Davis MG, Almaghlouth NK, Guevara R, Omar F, Del Rey F, Hassan A, Arian MU, Antony N, Prakash BV. J Med Virol2021 0193(1):491-498http://www.ncbi.nlm.nih.gov/pubmed/32530531Are coinfections with COVID-19 and influenza low or underreported? An observational study examining current published literature including three new unpublished cases. J Med Virol. 2020 11; 92(11):2489-2497.Antony SJ, Almaghlouth NK, Heydemann EL. J Med Virol2020 1192(11):2489-2497http://www.ncbi.nlm.nih.gov/pubmed/32642434Falsely positive fourth generation ADVIA Centaur® HIV Antigen/Antibody Combo assay in the presence of autoimmune hepatitis type I (AIH). IDCases. 2020; 21:e00886.Robinson MA, Nagurla SR, Noblitt TR, Almaghlouth NK, Al-Rahamneh MM, Cashin LM. IDCases202021:e008862,6-Dichloroindophenol18.396617605740157e-0012023-11-17T00:00:002023-11-17T00:00:00Cytomegalovirus15.691604299602607e-0012023-11-17T00:00:002023-11-17T00:00:00Fibrin Fibrinogen Degradation Products15.618380952088945e-0012020-10-10T00:00:002020-10-10T00:00:00Multiple Organ Failure15.391227905117414e-0012020-10-10T00:00:002020-10-10T00:00:00Cytomegalovirus Infections14.994283892857839e-0012023-11-17T00:00:002023-11-17T00:00:00Interleukin-623.506112590675095e-0012020-07-15T00:00:002020-10-10T00:00:00Meningitis, Escherichia coli12.128716947673239e-0012024-01-04T00:00:002024-01-04T00:00:00Texas21.890480720876699e-0012020-06-29T00:00:002020-10-10T00:00:00Meningitis11.797611098185697e-0012024-01-04T00:00:002024-01-04T00:00:00Interleukin-6 Inhibitors11.543290133731557e-0012020-07-15T00:00:002020-07-15T00:00:00Escherichia coli Infections11.534684385686126e-0012024-01-04T00:00:002024-01-04T00:00:00COVID-1941.440519386851233e-0012020-06-29T00:00:002023-02-13T00:00:00Transplant Recipients11.437850775796985e-0012023-11-17T00:00:002023-11-17T00:00:00DNA, Viral11.238272973134090e-0012023-11-17T00:00:002023-11-17T00:00:00Coinfection11.081609466968090e-0012020-06-29T00:00:002020-06-29T00:00:00Respiratory Insufficiency18.823761670761915e-0022020-07-15T00:00:002020-07-15T00:00:00COVID-19 Drug Treatment18.816733336763022e-0022020-07-15T00:00:002020-07-15T00:00:00Antiviral Agents18.446346038178494e-0022023-11-17T00:00:002023-11-17T00:00:00CD8-Positive T-Lymphocytes17.685421035791437e-0022023-11-17T00:00:002023-11-17T00:00:00Influenza, Human17.303006550575619e-0022020-06-29T00:00:002020-06-29T00:00:00Longitudinal Studies15.070957315194952e-0022020-10-10T00:00:002020-10-10T00:00:00Antibodies, Monoclonal, Humanized14.928560563902407e-0022020-07-15T00:00:002020-07-15T00:00:00Prognosis13.847647443596866e-0022020-10-10T00:00:002020-10-10T00:00:00Prospective Studies13.648740729407785e-0022023-11-17T00:00:002023-11-17T00:00:00Biomarkers13.549134355847634e-0022020-10-10T00:00:002020-10-10T00:00:00SARS-CoV-213.518412183901334e-0022020-07-15T00:00:002020-07-15T00:00:00Morbidity13.345599865160388e-0022023-02-13T00:00:002023-02-13T00:00:00Aged42.902275711295740e-0022020-06-29T00:00:002024-01-04T00:00:00Outpatients12.822057783252330e-0022023-02-13T00:00:002023-02-13T00:00:00Middle Aged42.570782903445408e-0022020-06-29T00:00:002023-02-13T00:00:00Neoplasms12.508738200841983e-0022023-02-13T00:00:002023-02-13T00:00:00Humans62.461534791571796e-0022020-06-29T00:00:002024-01-04T00:00:00Risk Factors12.457964610678909e-0022020-10-10T00:00:002020-10-10T00:00:00Drug Administration Schedule12.367803630205707e-0022020-07-15T00:00:002020-07-15T00:00:00Escherichia coli12.216330528032034e-0022024-01-04T00:00:002024-01-04T00:00:00Adult32.147402984902529e-0022020-06-29T00:00:002020-10-10T00:00:00Female41.912729579306045e-0022020-06-29T00:00:002024-01-04T00:00:00Male31.670456453918272e-0022020-06-29T00:00:002020-10-10T00:00:00Antibodies, Monoclonal11.478963981238896e-0022023-02-13T00:00:002023-02-13T00:00:00Anti-Bacterial Agents11.363104524885361e-0022024-01-04T00:00:002024-01-04T00:00:00Tomography, X-Ray Computed17.850917734531237e-0032020-06-29T00:00:002020-06-29T00:00:00Jamil Almohtasib, M.D.JamilAlmohtasib

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryResearch Fellow in SurgeryFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=298628555http://www.ncbi.nlm.nih.gov/pubmed/41240014Study recruitment challenges when conducting a randomized controlled trial comparing long- and short-acting local anesthetics for pain control after penile prosthesis. J Sex Med. 2026 Jan 05; 23(1).Almohtasib J, Anians W, Parikh N, Helo S, Kohler T, Yang D, Ziegelmann MJ. J Sex Med2026 Jan 0523(1)http://www.ncbi.nlm.nih.gov/pubmed/41372083Dynamic prognostication of non-muscle invasive bladder cancer using conditional recurrence- and progression-free survival: A SEER-Medicare analysis. Urol Oncol. 2026 Feb; 44(2):119.e7-119.e16.Chang JC, Perez-Londoño A, Kaul S, Almohtasib J, Fleishman A, Korets R, Chang P, Wagner A, Bellmunt J, Olumi AF, Gershman B. Urol Oncol2026 Feb44(2):119.e7-119.e16http://www.ncbi.nlm.nih.gov/pubmed/40660625Assessing Acute and Long-Term Toxicities of Proton Radiation Therapy in Pediatric Pelvic Tumors: Findings From the Pediatric Proton Consortium Registry. Pediatr Blood Cancer. 2025 Oct; 72(10):e31811.Almohtasib J, Indelicato DJ, Paulino AC, Mihalcik S, Lee J, Ermoian R, Chang JH, Kwok Y, Perentesis J, Perkins SM, Hill-Kayser C, Zeina W, Laack NN, Yock TI, Gargollo PC. Pediatr Blood Cancer2025 Oct72(10):e31811http://www.ncbi.nlm.nih.gov/pubmed/40310029Treatment Access and Caregiver Experience in Pediatric Rhabdomyosarcoma: Results of an Online Survey. Children (Basel). 2025 Mar 29; 12(4).Almohtasib J, Boswell TC, Granberg CF, Gargollo PC. Children (Basel)2025 Mar 2912(4)http://www.ncbi.nlm.nih.gov/pubmed/38802816Postoperative pneumonia after femoral fracture surgery: an in-depth retrospective analysis. BMC Musculoskelet Disord. 2024 May 27; 25(1):413.Hamdan M, Haddad BI, Almohtasib J, Eid M, Al-Din TJ, Rayyan HA, Altantawi AM, Akaheal AS, Alshrouf MA. BMC Musculoskelet Disord2024 May 2725(1):413http://www.ncbi.nlm.nih.gov/pubmed/37670521Perceived attitudes and barriers towards medical research: a survey of Jordanian interns, residents, and other postgraduates. Korean J Med Educ. 2023 Sep; 35(3):249-261.AlMohtasib J, Al-Huneidy L, Taha H, Rayyan R, Mansour S, Samhouri J, Hammouri M, Al-Somadi H, Bedros AW, Al-Omairi J, Abbas R, Abu-Usba MI, Al-Ani A. Korean J Med Educ2023 Sep35(3):249-261http://www.ncbi.nlm.nih.gov/pubmed/37464087Factors influencing gender preference towards surgeons among Jordanian adults: an investigation of healthcare bias. Sci Rep. 2023 07 18; 13(1):11614.AlSamhori JF, Rayyan R, Hammouri M, Taha H, Al-Huneidy L, AlOweiwi W, AlMohtasib J, Mansour S, Dardas M, Qiqieh J, Halasa Z, Al-Huneidy Y, Al-Ani A. Sci Rep2023 07 1813(1):11614http://www.ncbi.nlm.nih.gov/pubmed/36901027Current Awareness Status of and Recommendations for Polycystic Ovarian Syndrome: A National Cross-Sectional Investigation of Central Jordan. Int J Environ Res Public Health. 2023 02 23; 20(5).Muhaidat N, Mansour S, Dardas M, Qiqieh J, Halasa Z, Al-Huneidy L, Samhouri J, Rayyan R, AlOweiwi W, AlMohtasib J, Alshrouf MA, Al-Labadi GM, Suboh LH, Al-Ani A. Int J Environ Res Public Health2023 02 2320(5)Pelvic Neoplasms18.014327361912051e-0012025-07-14T00:00:002025-07-14T00:00:00Academic Success17.225542184457781e-0012023-08-31T00:00:002023-08-31T00:00:00Radiation Injuries15.367320102365831e-0012025-07-14T00:00:002025-07-14T00:00:00Proton Therapy14.223180425684207e-0012025-07-14T00:00:002025-07-14T00:00:00Jordan32.962375960720564e-0012023-02-23T00:00:002023-08-31T00:00:00Registries12.873876578397884e-0012025-07-14T00:00:002025-07-14T00:00:00Biomedical Research12.668636440983536e-0012023-08-31T00:00:002023-08-31T00:00:00Femoral Fractures11.573884263457106e-0012024-05-27T00:00:002024-05-27T00:00:00Sexism11.546504784658839e-0012023-07-18T00:00:002023-07-18T00:00:00Attitude11.435946882110600e-0012023-08-31T00:00:002023-08-31T00:00:00Polycystic Ovary Syndrome11.345188029005408e-0012023-02-23T00:00:002023-02-23T00:00:00Urinary Bladder Neoplasms19.784498829674938e-0022025-12-09T00:00:002025-12-09T00:00:00Pneumonia19.320505916308099e-0022024-05-27T00:00:002024-05-27T00:00:00Surgeons18.350361487307943e-0022023-07-18T00:00:002023-07-18T00:00:00Length of Stay17.942148114943494e-0022024-05-27T00:00:002024-05-27T00:00:00Incidence27.681197221222184e-0022024-05-27T00:00:002025-07-14T00:00:00Prognosis26.726885815178546e-0022025-07-14T00:00:002025-12-09T00:00:00Neoplasm Recurrence, Local16.344944890987278e-0022025-12-09T00:00:002025-12-09T00:00:00Non-Muscle Invasive Bladder Neoplasms15.827083197289885e-0022025-12-09T00:00:002025-12-09T00:00:00Surveys and Questionnaires25.477152319823317e-0022023-07-18T00:00:002023-08-31T00:00:00Follow-Up Studies15.087135344385211e-0022025-07-14T00:00:002025-07-14T00:00:00Risk Factors34.932774005854086e-0022023-02-23T00:00:002025-07-14T00:00:00Infant14.783844525645730e-0022025-07-14T00:00:002025-07-14T00:00:00Fracture Fixation, Intramedullary14.657820181907596e-0022024-05-27T00:00:002024-05-27T00:00:00Child, Preschool14.524187000200104e-0022025-07-14T00:00:002025-07-14T00:00:00Postoperative Complications14.225725320601167e-0022024-05-27T00:00:002024-05-27T00:00:00Progression-Free Survival14.044504910325367e-0022025-12-09T00:00:002025-12-09T00:00:00SEER Program14.032536050499197e-0022025-12-09T00:00:002025-12-09T00:00:00Neoplasm Invasiveness13.342225245502657e-0022025-12-09T00:00:002025-12-09T00:00:00Child13.159586397132775e-0022025-07-14T00:00:002025-07-14T00:00:00Adolescent13.113723356300815e-0022025-07-14T00:00:002025-07-14T00:00:00Male52.988216614058984e-0022023-02-23T00:00:002025-12-09T00:00:00Humans62.867969506933682e-0022023-02-23T00:00:002025-12-09T00:00:00Female52.828275375299092e-0022023-02-23T00:00:002025-12-09T00:00:00Patient Preference12.756449003597892e-0022023-07-18T00:00:002023-07-18T00:00:00Arthroplasty, Replacement, Hip12.438755664034804e-0022024-05-27T00:00:002024-05-27T00:00:00Cross-Sectional Studies22.175013868284601e-0022023-02-23T00:00:002023-07-18T00:00:00Intensive Care Units12.061748485144896e-0022024-05-27T00:00:002024-05-27T00:00:00Hospital Mortality12.003499568608629e-0022024-05-27T00:00:002024-05-27T00:00:00Aged, 80 and over21.862678525240093e-0022024-05-27T00:00:002025-12-09T00:00:00Comorbidity11.770363746320356e-0022023-02-23T00:00:002023-02-23T00:00:00Medicare11.625717308682464e-0022025-12-09T00:00:002025-12-09T00:00:00Prevalence11.583163551576934e-0022024-05-27T00:00:002024-05-27T00:00:00Aged21.092544233582818e-0022024-05-27T00:00:002025-12-09T00:00:00Middle Aged28.872737246973437e-0032023-02-23T00:00:002024-05-27T00:00:00Adult28.605504109239793e-0032023-02-23T00:00:002023-07-18T00:00:00United States18.156167128122610e-0032025-12-09T00:00:002025-12-09T00:00:00Retrospective Studies16.850018067945025e-0032024-05-27T00:00:002024-05-27T00:00:00Angie Alonso, M.D.AngieAlonso

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617 6677000

1BIDMCBeth Israel Deaconess Medical CenterNeurologyResearch Fellow in NeurologyFellow or Post DocCarolyn D Alonso, M.D.CarolynAlonso

Beth Israel Deaconess Medical CenterLowry Medical Office Bldg - Ste GB110 Francis StreetBoston, MA 02215617/632-0760

1BIDMCBeth Israel Deaconess Medical CenterMedicineInfectious DiseaseAssociate Professor of MedicineAssociate Professorhttp://www.ncbi.nlm.nih.gov/pubmed/39873391Comparative Outcomes of Babesiosis in Immunocompromised and Nonimmunocompromised Hosts: A Multicenter Cohort Study. Clin Infect Dis. 2025 Dec 24; 81(5):987-994.Kakoullis L, Alonso CD, Burns R, Aleissa MM, Haddad EA, Kim AJ, Rooks R, Yates B, Kanwal U, Morreale NP, Morgan A, Arnaout R, Tong A, Izaguirre NE, Little JS, Hammond SP, Montgomery MW, Sherman AC, Maguire JH, Woolley AE, Baden LR, Issa NC, Harris CE. Clin Infect Dis2025 Dec 2481(5):987-994http://www.ncbi.nlm.nih.gov/pubmed/41244275Disseminated Lomentospora prolificans infection in a neutropenic patient with acute monocytic leukemia: a clinical and diagnostic challenge. ASM Case Rep. 2025 Nov; 1(6).Amaya S, Giovannini-Sanguineti G, Lopez C, Alonso CD, Riedel S. ASM Case Rep2025 Nov1(6)http://www.ncbi.nlm.nih.gov/pubmed/40366862Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions in C. difficile infection (CDI), asymptomatic carriage and non-CDI diarrhea. Gut Microbes. 2025 Dec; 17(1):2505269.Wang L, Chen X, Pollock NR, Villafuerte Gálvez JA, Alonso CD, Wang D, Daugherty K, Xu H, Yao J, Chen Y, Kelly CP, Cao Y. Gut Microbes2025 Dec17(1):2505269http://www.ncbi.nlm.nih.gov/pubmed/40177588Safety and Efficacy of Fecal Microbiota, Live-jslm, in Preventing Recurrent Clostridioides difficile Infection in Participants Who Were Mildly to Moderately Immunocompromised in the Phase 3 PUNCH CD3-OLS Study. Open Forum Infect Dis. 2025 Apr; 12(4):ofaf117.Alonso CD, Tillotson GS, Bidell MR, Guthmueller B, Hoeyer F, Fischer M, Dubberke ER. Open Forum Infect Dis2025 Apr12(4):ofaf117http://www.ncbi.nlm.nih.gov/pubmed/39498173Oral Vancomycin to Prevent Clostridioides difficile in Stem Cell Transplant Recipients: The Last Frontier in Antimicrobial Prophylaxis. Open Forum Infect Dis. 2024 Nov; 11(11):ofae623.Alonso CD. Open Forum Infect Dis2024 Nov11(11):ofae623http://www.ncbi.nlm.nih.gov/pubmed/39411667Informing estimates of probability of Clostridioides difficile infection for testing and treatment: expert consensus from a modified-Delphi procedure. Antimicrob Steward Healthc Epidemiol. 2024; 4(1):e168.Baghdadi JD, Wessel M, Dubberke ER, Lydecker A, Claeys KC, Alonso C, Coffey KC, Durkin M, Gonzales-Luna AJ, Guh AY, Kwon JH, Martin E, Mehrotra P, Polage CR, Pulia MS, Rock C, Skinner AM, Vaughn VM, Vijayan T, Yarrington ME, Morgan DJ. Antimicrob Steward Healthc Epidemiol20244(1):e168http://www.ncbi.nlm.nih.gov/pubmed/39195623Best Practices in the Management of Clostridioides difficile Infection in Developing Nations. Trop Med Infect Dis. 2024 Aug 19; 9(8).Mendo-Lopez R, Alonso CD, Villafuerte-Gálvez JA. Trop Med Infect Dis2024 Aug 199(8)http://www.ncbi.nlm.nih.gov/pubmed/39006315Efficacy of Fecal Microbiota, Live-jslm (REBYOTA®), Among Patients Exposed to Non-Clostridioides difficile Infection Antibiotics: Post Hoc Subgroup Analysis of a Phase 2 Open-Label Study. Open Forum Infect Dis. 2024 Jul; 11(7):ofae341.Reveles KR, Gonzales-Luna AJ, Golan Y, Alonso CD, Guthmueller B, Tan X, Bidell MR, Pokhilko V, Crawford CV, Skinner AM. Open Forum Infect Dis2024 Jul11(7):ofae341http://www.ncbi.nlm.nih.gov/pubmed/38698669Influence of induction therapy and antiretroviral regimen on outcomes in kidney transplant recipients living with human immunodeficiency. Transpl Infect Dis. 2024 Aug; 26(4):e14287.Marks CR, Durand CM, Bowring MG, Hand J, Abidi MZ, Malinis M, Barnaba B, Patel H, Pavlakis M, Alonso CD. Transpl Infect Dis2024 Aug26(4):e14287http://www.ncbi.nlm.nih.gov/pubmed/38516923Epidemiology and outcomes associated with enterococcal blood stream infection among liver and kidney transplant recipients. Clin Transplant. 2024 03; 38(3):e15285.He KD, Naqvi SS, Cowan VL, Stack CM, Alonso CD, Blair BM. Clin Transplant2024 0338(3):e15285http://www.ncbi.nlm.nih.gov/pubmed/38283325Single-Center Outcomes of Epstein-Barr Virus DNAemia in Adult Solid Organ Transplant Recipients. J Transplant. 2024; 2024:5598324.Dong SW, Blair BM, Alonso CD. J Transplant20242024:5598324http://www.ncbi.nlm.nih.gov/pubmed/37977229Adjunctive glucocorticoid therapy for Pneumocystis jirovecii pneumonia in solid organ transplant recipients: A multicenter cohort, 2015-2020. Am J Transplant. 2024 Apr; 24(4):653-668.Hosseini-Moghaddam SM, Kothari S, Humar A, Albasata H, Yetmar ZA, Razonable RR, Neofytos D, D'Asaro M, Boggian K, Hirzel C, Khanna N, Manuel O, Mueller NJ, Imlay H, Kabbani D, Tyagi V, Smibert OC, Nasra M, Fontana L, Obeid KM, Apostolopoulou A, Zhang SX, Permpalung N, Alhatimi H, Silverman MS, Guo H, Rogers BA, MacKenzie E, Pisano J, Gioia F, Rapi L, Prasad GVR, Banegas M, Alonso CD, Doss K, Rakita RM, Fishman JA. Am J Transplant2024 Apr24(4):653-668http://www.ncbi.nlm.nih.gov/pubmed/37661468Tixagevimab-Cilgavimab Decreases the Rate of SARS-CoV-2 Infection Among Solid Organ Transplant Recipients. Transplant Proc. 2023 Oct; 55(8):1784-1792.Sanayei AM, Montalvan A, Faria I, Ochalla J, Pavlakis M, Blair BM, Alonso CD, Curry M, Saberi B. Transplant Proc2023 Oct55(8):1784-1792http://www.ncbi.nlm.nih.gov/pubmed/37549387How Would You Manage This Patient With Clostridioides difficile Infection? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2023 08; 176(8):1101-1108.Kanjee Z, Allegretti JR, Alonso CD, Burns RB. Ann Intern Med2023 08176(8):1101-1108http://www.ncbi.nlm.nih.gov/pubmed/36533701Reply to Ito. Clin Infect Dis. 2023 04 17; 76(8):1529-1530.Villafuerte-Gálvez JA, Pollock NR, Alonso CD, Chen X, Xu H, Wang L, White N, Banz A, Miller M, Daugherty K, Gonzalez-Luna AJ, Barrett C, Sprague R, Garey KW, Kelly CP. Clin Infect Dis2023 04 1776(8):1529-1530http://www.ncbi.nlm.nih.gov/pubmed/37062301Redefining Clostridioides difficile infection antibiotic response and clinical outcomes. Lancet Infect Dis. 2023 07; 23(7):e259-e265.Gonzales-Luna AJ, Skinner AM, Alonso CD, Bouza E, Cornely OA, de Meij TGJ, Drew RJ, Garey KW, Gerding DN, Johnson S, Kahn SA, Kato H, Kelly CP, Kelly CR, Kociolek LK, Kuijper EJ, Louie T, Riley TV, Sandora TJ, Vehreschild MJGT, Wilcox MH, Dubberke ER. Lancet Infect Dis2023 0723(7):e259-e265http://www.ncbi.nlm.nih.gov/pubmed/36949876Preservation of the Innate Immune Response to Clostridioides difficile Infection in Hospitalized Immunocompromised Patients. Open Forum Infect Dis. 2023 Mar; 10(3):ofad090.Banegas M, Villafuerte-Gálvez J, Paredes R, Sprague R, Barrett C, Gonzales-Luna AJ, Daugherty K, Garey KW, Xu H, Lin Q, Wang L, Chen X, Pollock NR, Kelly CP, Alonso CD. Open Forum Infect Dis2023 Mar10(3):ofad090http://www.ncbi.nlm.nih.gov/pubmed/35906836Stool Interleukin-1ß Differentiates Clostridioides difficile Infection (CDI) From Asymptomatic Carriage and Non-CDI Diarrhea. Clin Infect Dis. 2023 02 08; 76(3):e1467-e1475.Villafuerte Gálvez JA, Pollock NR, Alonso CD, Chen X, Xu H, Wang L, White N, Banz A, Miller M, Daugherty K, Gonzalez-Luna AJ, Barrett C, Sprague R, Garey KW, Kelly CP. Clin Infect Dis2023 02 0876(3):e1467-e1475http://www.ncbi.nlm.nih.gov/pubmed/35607815Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection. Clin Infect Dis. 2022 11 30; 75(11):2019-2022.Alonso CD, Pollock NR, Garey KW, Gonzales-Luna AJ, Williams DN, Daugherty K, Cuddemi C, Villafuerte-Gálvez J, White NC, Chen X, Xu H, Sprague R, Barrett C, Miller M, Foussadier A, Lantz A, Banz A, Kelly CP. Clin Infect Dis2022 11 3075(11):2019-2022http://www.ncbi.nlm.nih.gov/pubmed/36096946Insights From the Eye for Patients With Kidney Transplant. Transplant Proc. 2022 Oct; 54(8):2182-2191.Xu C, Prager AJ, Alonso CD, Pawar AS. Transplant Proc2022 Oct54(8):2182-2191http://www.ncbi.nlm.nih.gov/pubmed/34537841Ultrasensitive and Quantitative Toxin Measurement Correlates With Baseline Severity, Severe Outcomes, and Recurrence Among Hospitalized Patients With Clostridioides difficile Infection. Clin Infect Dis. 2022 07 06; 74(12):2142-2149.Alonso CD, Kelly CP, Garey KW, Gonzales-Luna AJ, Williams D, Daugherty K, Cuddemi C, Villafuerte-Gálvez J, White NC, Chen X, Xu H, Sprague R, Barrett C, Miller M, Foussadier A, Lantz A, Banz A, Pollock NR. Clin Infect Dis2022 07 0674(12):2142-2149http://www.ncbi.nlm.nih.gov/pubmed/35026839Comparative outcomes for mature T-cell and NK/T-cell lymphomas in people with and without HIV and to AIDS-defining lymphomas. Blood Adv. 2022 03 08; 6(5):1420-1431.Koh MJ, Merrill MH, Koh MJ, Stuver R, Alonso CD, Foss FM, Mayor AM, Gill J, Epeldegui M, Cachay E, Thorne JE, Silverberg MJ, Horberg MA, Althoff KN, Nijhawan AE, McGinnis KA, Lee JS, Rabkin CS, Napravnik S, Li J, Castilho JL, Shen C, Jain S. Blood Adv2022 03 086(5):1420-1431http://www.ncbi.nlm.nih.gov/pubmed/35202891American Society for Transplantation and Cellular Therapy Series: #5-Management of Clostridioides difficile Infection in Hematopoietic Cell Transplant Recipients. Transplant Cell Ther. 2022 05; 28(5):225-232.Alonso CD, Maron G, Kamboj M, Carpenter PA, Gurunathan A, Mullane KM, Dubberke ER. Transplant Cell Ther2022 0528(5):225-232http://www.ncbi.nlm.nih.gov/pubmed/34324678Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study. J Antimicrob Chemother. 2021 10 11; 76(11):3020-3028.Stern A, Alonso CD, Garcia-Vidal C, Cardozo C, Slavin M, Yong MK, Ho SA, Mehta Steinke S, Avery RK, Koehler P, Scheid C, Cornely OA, Maertens J, Abi Aad Y, Epstein DJ, Papanicolaou GA, Neofytos D. J Antimicrob Chemother2021 10 1176(11):3020-3028http://www.ncbi.nlm.nih.gov/pubmed/34237021Case Report: Refractory Cryptosporidiosis after CAR T-Cell Therapy for Lymphoma. Am J Trop Med Hyg. 2021 07 08; 105(3):651-653.Trottier CA, Yen CF, Malvar G, Arnason J, Avigan DE, Alonso CD. Am J Trop Med Hyg2021 07 08105(3):651-653http://www.ncbi.nlm.nih.gov/pubmed/34258317Humoral Immune Response to Clostridioides difficile Toxins A and B in Hospitalized Immunocompromised Patients With C difficile Infection. Open Forum Infect Dis. 2021 Jul; 8(7):ofab286.Alonso CD, Papamichael K, Sprague R, Barrett C, Gonzales-Luna AJ, Daugherty K, Garey KW, Villafuerte-Gálvez J, Xu H, Lin Q, Wang L, Chen X, Pollock NR, Kelly CP. Open Forum Infect Dis2021 Jul8(7):ofab286http://www.ncbi.nlm.nih.gov/pubmed/33704352Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19. JAMA. 2021 04 20; 325(15):1535-1544.Stephenson KE, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Truyers C, Atyeo C, Loos C, Chandrashekar A, McMahan K, Tostanoski LH, Yu J, Gebre MS, Jacob-Dolan C, Li Z, Patel S, Peter L, Liu J, Borducchi EN, Nkolola JP, Souza M, Tan CS, Zash R, Julg B, Nathavitharana RR, Shapiro RL, Azim AA, Alonso CD, Jaegle K, Ansel JL, Kanjilal DG, Guiney CJ, Bradshaw C, Tyler A, Makoni T, Yanosick KE, Seaman MS, Lauffenburger DA, Alter G, Struyf F, Douoguih M, Van Hoof J, Schuitemaker H, Barouch DH. JAMA2021 04 20325(15):1535-1544http://www.ncbi.nlm.nih.gov/pubmed/33223246Casting a wider protective net: Anti-infective vaccine strategies for patients with hematologic malignancy and blood and marrow transplantation. Blood Rev. 2021 05; 47:100779.McMasters M, Blair BM, Lazarus HM, Alonso CD. Blood Rev2021 0547:100779http://www.ncbi.nlm.nih.gov/pubmed/33164145Absence of Toxemia in Clostridioides difficile Infection: Results from Ultrasensitive Toxin Assay of Serum. Dig Dis Sci. 2021 10; 66(10):3303-3306.Sprague R, Warny K, Pollock N, Daugherty K, Lin Q, Xu H, Cuddemi C, Barrett C, Chen X, Banz A, Lantz A, Garey KW, Gonzales-Luna AJ, Alonso CD, Galvez JAV, Kelly CP. Dig Dis Sci2021 1066(10):3303-3306http://www.ncbi.nlm.nih.gov/pubmed/31584632Laxative Use Does Not Preclude Diagnosis or Reduce Disease Severity in Clostridiodes difficile Infection. Clin Infect Dis. 2020 09 12; 71(6):1472-1478.White NC, Mendo-Lopez R, Papamichael K, Cuddemi CA, Barrett C, Daugherty K, Pollock N, Kelly CP, Alonso CD. Clin Infect Dis2020 09 1271(6):1472-1478http://www.ncbi.nlm.nih.gov/pubmed/33094122Beyond the Superficial: Disseminated Trichophyton rubrum Infection in a Kidney Transplant Recipient. Open Forum Infect Dis. 2020 Jul; 7(7):ofaa281.Trottier CA, Jhaveri VV, Zimarowski MJ, Blair BM, Alonso CD. Open Forum Infect Dis2020 Jul7(7):ofaa281http://www.ncbi.nlm.nih.gov/pubmed/32091351Identification of a norovirus outbreak on a hematopoietic stem cell transplant unit and development and implementation of a novel infection prevention algorithm for controlling transmission. Infect Control Hosp Epidemiol. 2020 04; 41(4):472-476.Branch-Elliman W, Araujo-Castillo RV, Snyder GM, Sullivan BF, Alonso CD, Wright SB. Infect Control Hosp Epidemiol2020 0441(4):472-476http://www.ncbi.nlm.nih.gov/pubmed/31606481Recent developments in the management of recurrent Clostridioides difficile infection. Anaerobe. 2020 Apr; 62:102108.Mendo-Lopez R, Villafuerte-Gálvez J, White N, Mahoney MV, Kelly CP, Alonso CD. Anaerobe2020 Apr62:102108http://www.ncbi.nlm.nih.gov/pubmed/31493500Prevention of recurrent Clostridioides difficile infection: A systematic review of randomized controlled trials. Anaerobe. 2020 Feb; 61:102098.Madoff SE, Urquiaga M, Alonso CD, Kelly CP. Anaerobe2020 Feb61:102098http://www.ncbi.nlm.nih.gov/pubmed/30588042Bezlotoxumab for the prevention of Clostridium difficile infection: a review of current evidence and safety profile. Infect Drug Resist. 2019; 12:1-9.Alonso CD, Mahoney MV. Infect Drug Resist201912:1-9http://www.ncbi.nlm.nih.gov/pubmed/30403300Adjunctive Use of Cidofovir and Intravenous Immunoglobulin to Treat Invasive Adenoviral Disease in Solid Organ Transplant Recipients. Pharmacotherapy. 2018 12; 38(12):1260-1266.Permpalung N, Mahoney MV, Alonso CD. Pharmacotherapy2018 1238(12):1260-1266http://www.ncbi.nlm.nih.gov/pubmed/30011107Fecal microbiota transplantation for recurrent Clostridium difficile infection in patients with solid organ transplants: an institutional experience and review of the literature. Transpl Infect Dis. 2018 Dec; 20(6):e12967.Lin SC, Alonso CD, Moss AC. Transpl Infect Dis2018 Dec20(6):e12967http://www.ncbi.nlm.nih.gov/pubmed/29947555Clinical characteristics and treatment outcomes among respiratory syncytial virus (RSV)-infected hematologic malignancy and hematopoietic stem cell transplant recipients receiving palivizumab. Leuk Lymphoma. 2019 01; 60(1):85-91.Permpalung N, Mahoney MV, McCoy C, Atsawarungruangkit A, Gold HS, Levine JD, Wong MT, LaSalvia MT, Alonso CD. Leuk Lymphoma2019 0160(1):85-91http://www.ncbi.nlm.nih.gov/pubmed/28544102A multicenter, retrospective, case-cohort study of the epidemiology and risk factors for Clostridium difficile infection among cord blood transplant recipients. Transpl Infect Dis. 2017 Aug; 19(4).Alonso CD, Braun DA, Patel I, Akbari M, Oh DJ, Jun T, McMasters M, Hammond SP, Glotzbecker B, Cutler C, Leffler DA, Ballen KK, Kelly CP. Transpl Infect Dis2017 Aug19(4)http://www.ncbi.nlm.nih.gov/pubmed/28480750Bezlotoxumab: Could This be the Answer for Clostridium difficile Recurrence? Ann Pharmacother. 2017 Sep; 51(9):804-810.Chapin RW, Lee T, McCoy C, Alonso CD, Mahoney MV. Ann Pharmacother2017 Sep51(9):804-810http://www.ncbi.nlm.nih.gov/pubmed/28480257Does Adjunctive Tigecycline Improve Outcomes in Severe-Complicated, Nonoperative Clostridium difficile Infection? Open Forum Infect Dis. 2017; 4(1):ofw264.LaSalvia MT, Branch-Elliman W, Snyder GM, Mahoney MV, Alonso CD, Gold HS, Wright SB. Open Forum Infect Dis20174(1):ofw264http://www.ncbi.nlm.nih.gov/pubmed/27943498Risk factors for the development of Clostridium difficile infection in adult allogeneic hematopoietic stem cell transplant recipients: A single-center study in Québec, Canada. Transpl Infect Dis. 2017 Feb; 19(1).Lavallée C, Labbé AC, Talbot JD, Alonso CD, Marr KA, Cohen S, Laverdière M, Dufresne SF. Transpl Infect Dis2017 Feb19(1)http://www.ncbi.nlm.nih.gov/pubmed/28115504Lack of adherence to SHEA-IDSA treatment guidelines for Clostridium difficile infection is associated with increased mortality. 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Transpl Infect Dis2011 Aug13(4):392-6Clostridium Infections204.044057658367184e+0002012-03-12T00:00:002025-05-14T00:00:00Clostridioides difficile193.444917549370545e+0002012-03-12T00:00:002025-05-14T00:00:00Bacterial Toxins61.218971633141582e+0002017-05-06T00:00:002023-02-08T00:00:00Hematopoietic Stem Cell Transplantation119.995568903943932e-0012012-03-12T00:00:002022-02-22T00:00:00Transplant Recipients78.783679767848502e-0012017-07-12T00:00:002024-05-02T00:00:00Antilymphocyte Serum17.473714775819325e-0012024-05-02T00:00:002024-05-02T00:00:00Cryptosporidiosis16.852530611612235e-0012021-07-08T00:00:002021-07-08T00:00:00Cidofovir26.384035692204830e-0012018-11-26T00:00:002021-10-11T00:00:00Palivizumab15.646435705218674e-0012018-06-27T00:00:002018-06-27T00:00:00Adenoviridae Infections15.610912295774648e-0012018-11-26T00:00:002018-11-26T00:00:00Hematologic Neoplasms25.251617964705980e-0012018-06-27T00:00:002020-11-17T00:00:00Kidney Transplantation54.988916176556933e-0012012-11-23T00:00:002024-05-02T00:00:00Immunomodulation14.920429126714254e-0012020-11-17T00:00:002020-11-17T00:00:00Infection Control24.902274856077090e-0012020-02-24T00:00:002020-11-17T00:00:00Cross Infection34.887716968652069e-0012012-03-12T00:00:002020-02-24T00:00:00Sparganosis14.682817346021669e-0012015-06-01T00:00:002015-06-01T00:00:00Spirometra14.682817346021669e-0012015-06-01T00:00:002015-06-01T00:00:00Diarrhea44.434079171613861e-0012017-07-12T00:00:002025-05-14T00:00:00Immunosuppression Therapy24.386414361487993e-0012014-11-04T00:00:002024-05-02T00:00:00Lymphoma, B-Cell14.377236599309017e-0012021-07-08T00:00:002021-07-08T00:00:00Ehrlichiosis14.355244948810401e-0012014-11-11T00:00:002014-11-11T00:00:00Anaplasma phagocytophilum14.299624987639343e-0012014-11-11T00:00:002014-11-11T00:00:00Feces64.297057222744136e-0012018-07-31T00:00:002025-05-14T00:00:00Nontuberculous Mycobacteria14.264144684762707e-0012014-11-04T00:00:002014-11-04T00:00:00Immunoglobulins, Intravenous14.228781296993830e-0012018-11-26T00:00:002018-11-26T00:00:00Infections14.094583449514082e-0012020-11-17T00:00:002020-11-17T00:00:00Graft Survival13.951426925814792e-0012024-05-02T00:00:002024-05-02T00:00:00Bacteremia23.898009484556675e-0012014-11-11T00:00:002024-03-01T00:00:00Respiratory Syncytial Virus Infections13.883466487975034e-0012018-06-27T00:00:002018-06-27T00:00:00Bone Marrow Transplantation13.859466803210822e-0012020-11-17T00:00:002020-11-17T00:00:00Pregnancy Complications, Hematologic13.730297082553695e-0012014-11-11T00:00:002014-11-11T00:00:00Breast Diseases13.692153196294827e-0012015-06-01T00:00:002015-06-01T00:00:00Mycobacterium Infections, Nontuberculous13.681074411602462e-0012014-11-04T00:00:002014-11-04T00:00:00beta-Thalassemia13.657012014386789e-0012014-11-11T00:00:002014-11-11T00:00:00Vaccines13.656719299575759e-0012020-11-17T00:00:002020-11-17T00:00:00Enterotoxins33.617350406937968e-0012020-11-08T00:00:002023-02-08T00:00:00Psoas Abscess13.523579418554896e-0012011-05-18T00:00:002011-05-18T00:00:00Enterocolitis, Pseudomembranous13.490793080025122e-0012013-08-01T00:00:002013-08-01T00:00:00Graft Rejection23.449437336758384e-0012022-09-10T00:00:002024-05-02T00:00:00Fetal Blood13.289506055394924e-0012017-07-12T00:00:002017-07-12T00:00:00Respiratory Tract Infections13.234806118524572e-0012018-06-27T00:00:002018-06-27T00:00:00Fecal Microbiota Transplantation43.137821121866228e-0012018-07-31T00:00:002023-08-08T00:00:00Immunotherapy, Adoptive13.071412739167891e-0012021-07-08T00:00:002021-07-08T00:00:00Erythrocyte Transfusion13.057626661362681e-0012014-11-11T00:00:002014-11-11T00:00:00Immunologic Factors13.054340838324138e-0012018-11-26T00:00:002018-11-26T00:00:00Immunocompromised Host22.757603209765537e-0012021-07-08T00:00:002025-12-24T00:00:00Transplantation Conditioning22.664086673055369e-0012013-08-01T00:00:002017-01-11T00:00:00Carrier State22.605555397118937e-0012015-04-27T00:00:002025-05-14T00:00:00Antiviral Agents22.575740125394107e-0012018-11-26T00:00:002021-10-11T00:00:00Anti-Bacterial Agents122.567281261562261e-0012012-11-23T00:00:002024-03-01T00:00:00Organ Transplantation32.452076263796759e-0012013-02-21T00:00:002023-11-17T00:00:00Babesiosis12.161600905890318e-0012025-12-24T00:00:002025-12-24T00:00:00Methicillin-Resistant Staphylococcus aureus12.124648727662802e-0012011-05-18T00:00:002011-05-18T00:00:00Vancomycin-Resistant Enterococci12.030281719263573e-0012024-03-01T00:00:002024-03-01T00:00:00Recurrence61.989698293159515e-0012015-04-27T00:00:002022-07-06T00:00:00Antibodies, Bacterial21.969929548304771e-0012014-11-11T00:00:002022-11-30T00:00:00Pneumocystis carinii11.947930673114934e-0012023-11-17T00:00:002023-11-17T00:00:00Ribotyping11.932526253955021e-0012022-11-30T00:00:002022-11-30T00:00:00Electrophoresis, Gel, Pulsed-Field11.929966388872215e-0012022-11-30T00:00:002022-11-30T00:00:00Pregnancy Complications, Infectious11.877193766243367e-0012014-11-11T00:00:002014-11-11T00:00:00Pneumonia, Pneumocystis11.824052286194495e-0012023-11-17T00:00:002023-11-17T00:00:00Staphylococcal Infections11.802146196481331e-0012011-05-18T00:00:002011-05-18T00:00:00Lymphoma, AIDS-Related11.761424649980895e-0012022-03-08T00:00:002022-03-08T00:00:00Gram-Positive Bacterial Infections11.736801870251946e-0012024-03-01T00:00:002024-03-01T00:00:00Induction Chemotherapy11.722994133678903e-0012024-05-02T00:00:002024-05-02T00:00:00Toxemia11.706043324256888e-0012020-11-08T00:00:002020-11-08T00:00:00Mucormycosis21.667211277625341e-0012011-03-28T00:00:002013-02-21T00:00:00Retrospective Studies151.663302718694010e-0012011-05-18T00:00:002025-12-24T00:00:00Lymphoma, T-Cell, Peripheral11.586771098862913e-0012022-03-08T00:00:002022-03-08T00:00:00Humans421.576498302467365e-0012011-03-28T00:00:002025-12-24T00:00:00Laxatives11.563219322406112e-0012020-09-12T00:00:002020-09-12T00:00:00Norovirus11.560144542055260e-0012020-02-24T00:00:002020-02-24T00:00:00Treatment Outcome111.559155053534981e-0012011-05-18T00:00:002025-12-24T00:00:00Organophosphonates11.557982890423099e-0012021-10-11T00:00:002021-10-11T00:00:00Bacterial Proteins31.530149522403234e-0012017-05-06T00:00:002022-11-30T00:00:00Immunoenzyme Techniques11.510486299753831e-0012022-07-06T00:00:002022-07-06T00:00:00Antibodies, Neutralizing21.484686427039814e-0012017-05-06T00:00:002021-04-20T00:00:00North America11.473889939640540e-0012022-11-30T00:00:002022-11-30T00:00:00Middle Aged231.401493854393676e-0012011-03-28T00:00:002025-12-24T00:00:00Gastroenteritis11.391437557386500e-0012020-02-24T00:00:002020-02-24T00:00:00Adult181.387238915029076e-0012011-05-18T00:00:002025-12-24T00:00:00HIV Infections11.317273727330365e-0012024-05-02T00:00:002024-05-02T00:00:00Pancreas Transplantation11.309869253388513e-0012018-07-31T00:00:002018-07-31T00:00:00Respiratory Syncytial Viruses11.306244254829106e-0012018-06-27T00:00:002018-06-27T00:00:00Cell- and Tissue-Based Therapy11.278614808294408e-0012022-02-22T00:00:002022-02-22T00:00:00Immunogenicity, Vaccine11.272301410495588e-0012021-04-20T00:00:002021-04-20T00:00:00Interleukin-1beta11.271585568909941e-0012023-02-08T00:00:002023-02-08T00:00:00Eye Diseases11.255128106145904e-0012022-09-10T00:00:002022-09-10T00:00:00Female231.226817450299526e-0012011-05-18T00:00:002025-12-24T00:00:00Food Parasitology11.175049428456168e-0012015-06-01T00:00:002015-06-01T00:00:00Praziquantel11.156628620386032e-0012015-06-01T00:00:002015-06-01T00:00:00Anura11.156067576617294e-0012015-06-01T00:00:002015-06-01T00:00:00Antiparasitic Agents11.135399522228551e-0012015-06-01T00:00:002015-06-01T00:00:00Metronidazole11.132706646807809e-0012016-11-14T00:00:002016-11-14T00:00:00Immunity, Cellular11.124660262673217e-0012021-04-20T00:00:002021-04-20T00:00:00Leukocyte Reduction Procedures11.124152996683213e-0012014-11-11T00:00:002014-11-11T00:00:00Foodborne Diseases11.118816199044836e-0012015-06-01T00:00:002015-06-01T00:00:00Blood Safety11.113460638987880e-0012014-11-11T00:00:002014-11-11T00:00:00Exophiala11.097856105182618e-0012014-06-03T00:00:002014-06-03T00:00:00Phaeohyphomycosis11.095280032909135e-0012014-06-03T00:00:002014-06-03T00:00:00Virus Activation11.091104328854932e-0012017-01-11T00:00:002017-01-11T00:00:00Anti-Retroviral Agents11.079141739434242e-0012024-05-02T00:00:002024-05-02T00:00:00Hodgkin Disease11.055014632218997e-0012022-03-08T00:00:002022-03-08T00:00:00Immunosuppressive Agents21.047660152450903e-0012023-09-01T00:00:002024-05-02T00:00:00Antibiotic Prophylaxis11.047501060753120e-0012019-10-10T00:00:002019-10-10T00:00:00Fluorescent Antibody Technique, Indirect11.045135390757416e-0012014-11-11T00:00:002014-11-11T00:00:00Male211.025154275545255e-0012011-03-28T00:00:002025-12-24T00:00:00Food Contamination11.015887323016362e-0012015-06-01T00:00:002015-06-01T00:00:00Bacteria11.012244925326939e-0012025-05-14T00:00:002025-05-14T00:00:00Acquired Immunodeficiency Syndrome11.003888115069520e-0012022-03-08T00:00:002022-03-08T00:00:00Vancomycin19.934231373319573e-0022016-11-14T00:00:002016-11-14T00:00:00Incidence69.832687267341100e-0022011-05-18T00:00:002017-01-11T00:00:00Blood Donors19.418366465324693e-0022014-11-11T00:00:002014-11-11T00:00:00Communicable Diseases, Emerging19.290974357779315e-0022014-06-03T00:00:002014-06-03T00:00:00Rifampin19.147873573066542e-0022014-11-11T00:00:002014-11-11T00:00:00Opportunistic Infections29.064137330492104e-0022011-03-28T00:00:002014-06-03T00:00:00Risk Factors98.921123688230259e-0022012-03-12T00:00:002024-03-01T00:00:00Cytomegalovirus18.852144350519454e-0022017-01-11T00:00:002017-01-11T00:00:00Drug Therapy, Combination28.769636797543037e-0022016-11-14T00:00:002018-11-26T00:00:00Kidney Failure, Chronic18.736002509314145e-0022024-05-02T00:00:002024-05-02T00:00:00Rhizopus18.698957413074214e-0022011-03-28T00:00:002011-03-28T00:00:00Lymphoma, Large B-Cell, Diffuse18.694098203610087e-0022022-03-08T00:00:002022-03-08T00:00:00Aged, 80 and over58.653162152739923e-0022011-05-18T00:00:002025-12-24T00:00:00Fournier Gangrene18.636348403464558e-0022011-03-28T00:00:002011-03-28T00:00:00Aspergillosis18.545578241035093e-0022013-02-21T00:00:002013-02-21T00:00:00Dermatomycoses18.499600123236163e-0022011-03-28T00:00:002011-03-28T00:00:00Length of Stay28.489832163393329e-0022011-05-18T00:00:002018-06-27T00:00:00Combined Modality Therapy28.418877662947899e-0022019-09-04T00:00:002019-10-10T00:00:00Penile Diseases18.408032713547198e-0022011-03-28T00:00:002011-03-28T00:00:00Graft vs Host Disease28.371816616007385e-0022013-08-01T00:00:002014-06-03T00:00:00Baltimore18.351665602543482e-0022011-05-18T00:00:002011-05-18T00:00:00Delayed Diagnosis18.170045043231083e-0022014-11-11T00:00:002014-11-11T00:00:00Gastrointestinal Microbiome18.070592773663080e-0022025-05-14T00:00:002025-05-14T00:00:00Cytomegalovirus Infections17.767602879585044e-0022017-01-11T00:00:002017-01-11T00:00:00Viral Load17.580473384859610e-0022018-11-26T00:00:002018-11-26T00:00:00Antibodies, Viral17.543876554275758e-0022021-04-20T00:00:002021-04-20T00:00:00Aged127.311075707325569e-0022011-05-18T00:00:002025-12-24T00:00:00China17.234531329059810e-0022015-06-01T00:00:002015-06-01T00:00:00Disease Management17.156582830168107e-0022019-10-10T00:00:002019-10-10T00:00:00Transplantation, Autologous16.967593540028570e-0022013-08-01T00:00:002013-08-01T00:00:00Broadly Neutralizing Antibodies26.919900120450262e-0022017-05-06T00:00:002023-08-08T00:00:00Immunoglobulin A26.848766285462880e-0022020-11-08T00:00:002023-02-08T00:00:00COVID-19 Vaccines16.373428707683927e-0022021-04-20T00:00:002021-04-20T00:00:00Kaplan-Meier Estimate16.349297979759103e-0022017-07-12T00:00:002017-07-12T00:00:00Cohort Studies56.130339556560156e-0022012-11-23T00:00:002025-12-24T00:00:00Antibodies, Monoclonal, Humanized16.122422893230265e-0022023-09-01T00:00:002023-09-01T00:00:00Academic Medical Centers26.078667249053224e-0022011-05-18T00:00:002020-02-24T00:00:00Guideline Adherence16.017089538127234e-0022016-11-14T00:00:002016-11-14T00:00:00Case-Control Studies45.766341398255144e-0022012-03-12T00:00:002024-03-01T00:00:00Antibodies, Monoclonal25.493792642221658e-0022017-05-06T00:00:002023-08-08T00:00:00Hospital Mortality15.317958961565208e-0022018-06-27T00:00:002018-06-27T00:00:00Patient Readmission15.200741718047404e-0022018-06-27T00:00:002018-06-27T00:00:00Diabetes Mellitus15.131591232720262e-0022022-09-10T00:00:002022-09-10T00:00:00Anti-Infective Agents15.090330058200238e-0022011-05-18T00:00:002011-05-18T00:00:00Antitoxins14.774714341552481e-0022023-02-08T00:00:002023-02-08T00:00:00Proportional Hazards Models14.765350285043645e-0022017-07-12T00:00:002017-07-12T00:00:00Severity of Illness Index14.681354020757836e-0022020-09-12T00:00:002020-09-12T00:00:00Young Adult54.647756560545810e-0022011-05-18T00:00:002021-04-20T00:00:00COVID-1924.557194074736126e-0022021-04-20T00:00:002023-09-01T00:00:00Hypertension14.539810993017109e-0022022-09-10T00:00:002022-09-10T00:00:00Massachusetts14.442114570695949e-0022014-11-11T00:00:002014-11-11T00:00:00Vaccine Potency14.346704799982479e-0022021-04-20T00:00:002021-04-20T00:00:00Metagenomics14.217668062549307e-0022025-05-14T00:00:002025-05-14T00:00:00Cytosine14.091354937467560e-0022021-10-11T00:00:002021-10-11T00:00:00Immunoglobulin G23.985026983116431e-0022020-11-08T00:00:002023-02-08T00:00:00Caliciviridae Infections13.939681942159137e-0022020-02-24T00:00:002020-02-24T00:00:00Teaching Rounds13.714366921668667e-0022023-08-08T00:00:002023-08-08T00:00:00Immunity, Humoral13.225335135738439e-0022021-04-20T00:00:002021-04-20T00:00:00Quebec13.185439357147357e-0022017-01-11T00:00:002017-01-11T00:00:00Europe13.171620218141497e-0022023-11-17T00:00:002023-11-17T00:00:00Comorbidity13.131912180076474e-0022011-05-18T00:00:002011-05-18T00:00:00Mucositis12.918086300935237e-0022017-01-11T00:00:002017-01-11T00:00:00Trimethoprim, Sulfamethoxazole Drug Combination12.888640358429867e-0022017-01-11T00:00:002017-01-11T00:00:00Leukemia, Myeloid, Acute12.857791637245986e-0022011-03-28T00:00:002011-03-28T00:00:00Infant, Newborn12.636821087790928e-0022014-11-11T00:00:002014-11-11T00:00:00Glucocorticoids12.596969888027493e-0022023-11-17T00:00:002023-11-17T00:00:00Drug Resistance, Fungal12.549299421629886e-0022014-06-03T00:00:002014-06-03T00:00:00United States12.507930074724712e-0022022-02-22T00:00:002022-02-22T00:00:00Child12.498028243480806e-0022022-02-22T00:00:002022-02-22T00:00:00Time Factors22.467984991689962e-0022011-03-28T00:00:002012-03-12T00:00:00Pregnancy12.375134800821081e-0022014-11-11T00:00:002014-11-11T00:00:00Medical Records12.183209384617910e-0022016-11-14T00:00:002016-11-14T00:00:00Lymphoma, Mantle-Cell12.131263551019407e-0022014-06-03T00:00:002014-06-03T00:00:00Adolescent22.111861732437369e-0022012-11-23T00:00:002017-07-12T00:00:00Secondary Prevention12.111615963047045e-0022017-05-06T00:00:002017-05-06T00:00:00Disease Outbreaks12.023180281249416e-0022020-02-24T00:00:002020-02-24T00:00:00Colonoscopy11.951702949869039e-0022018-07-31T00:00:002018-07-31T00:00:00Antifungal Agents11.837295011978340e-0022014-06-03T00:00:002014-06-03T00:00:00Transplantation, Homologous11.731417888195992e-0022017-01-11T00:00:002017-01-11T00:00:00Colitis11.718790993148090e-0022016-11-14T00:00:002016-11-14T00:00:00Liver11.711088271767807e-0022024-03-01T00:00:002024-03-01T00:00:00Boston11.613418246616745e-0022020-02-24T00:00:002020-02-24T00:00:00Double-Blind Method11.568402019236363e-0022021-04-20T00:00:002021-04-20T00:00:00Animals21.555830958254524e-0022015-06-01T00:00:002017-05-06T00:00:00Practice Guidelines as Topic11.501188608719161e-0022023-08-08T00:00:002023-08-08T00:00:00T-Lymphocytes11.299721743722171e-0022022-03-08T00:00:002022-03-08T00:00:00Randomized Controlled Trials as Topic11.124723306336958e-0022019-09-04T00:00:002019-09-04T00:00:00SARS-CoV-211.092672344350863e-0022023-09-01T00:00:002023-09-01T00:00:00Clinical Trials as Topic11.046198721325631e-0022017-05-06T00:00:002017-05-06T00:00:00Quality of Life11.007931220954991e-0022022-09-10T00:00:002022-09-10T00:00:00Algorithms19.342150383297346e-0032020-02-24T00:00:002020-02-24T00:00:00Prospective Studies18.989527475095946e-0032023-09-01T00:00:002023-09-01T00:00:00Disease Progression16.380728533861467e-0032011-03-28T00:00:002011-03-28T00:00:00Okechukwu Aloziem, M.D.OkechukwuAloziem

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post DocUniversity of Pittsburgh School of MedicinePittsburgh, PAMD05/2025Doctor of Medicinehttp://www.ncbi.nlm.nih.gov/pubmed/40725744Feasibility of Hypotension Prediction Index-Guided Monitoring for Epidural Labor Analgesia: A Randomized Controlled Trial. J Clin Med. 2025 Jul 16; 14(14).Aloziem O, Lin HS, Kelly K, Nicholas A, Romeo RC, Smith CT, Yu X, Lim G. J Clin Med2025 Jul 1614(14)http://www.ncbi.nlm.nih.gov/pubmed/39946191Anesthesiologist Training in Empathetic Communication for Obstetric Emergencies Improves Patient-reported Outcomes. Anesthesiology. 2025 Apr 01; 142(4):761-763.Aloziem OU, Thurston AL, Romeo RC, Bauchat JR, Gopalan P, Smith CT, Lim G. Anesthesiology2025 Apr 01142(4):761-763http://www.ncbi.nlm.nih.gov/pubmed/38336915An artificial intelligence based abdominal aortic aneurysm prognosis classifier to predict patient outcomes. Sci Rep. 2024 02 09; 14(1):3390.Chung TK, Gueldner PH, Aloziem OU, Liang NL, Vorp DA. Sci Rep2024 02 0914(1):3390http://www.ncbi.nlm.nih.gov/pubmed/37256753Assessing Common Content and Responsiveness of the QoR-15 and the SF-8 in the Context of Recovery from Regional Anesthesia for Joint Replacement. Mil Med. 2023 11 03; 188(11-12):e3469-e3476.Aloziem OU, Williams BA, Mikolic JM, Boudreaux-Kelly MY, Faruque S, Piva SR, Ibinson JW, Switzer GE. Mil Med2023 11 03188(11-12):e3469-e3476http://www.ncbi.nlm.nih.gov/pubmed/37208305Validity of the Modified Defense and Veterans Pain Rating Scale Supplemented With Items Germane to Total Joint Replacement: Secondary Analysis From a Randomized Trial. Mil Med. 2023 08 29; 188(9-10):e3017-e3025.Piva SR, Switzer GE, Mikolic JM, Boudreaux-Kelly MY, Faruque S, Aloziem OU, Ibinson JW, Williams BA. Mil Med2023 08 29188(9-10):e3017-e3025Anesthesia, Conduction16.584067636103204e-0012023-11-03T00:00:002023-11-03T00:00:00Arthroplasty, Replacement, Knee13.650120267866330e-0012023-11-03T00:00:002023-11-03T00:00:00Knee Joint11.099445980293915e-0012023-11-03T00:00:002023-11-03T00:00:00Aortic Aneurysm, Abdominal11.044172489072262e-0012024-02-09T00:00:002024-02-09T00:00:00Military Personnel11.042335164929984e-0012023-08-29T00:00:002023-08-29T00:00:00Veterans17.441342631642207e-0022023-08-29T00:00:002023-08-29T00:00:00Artificial Intelligence16.371394376878263e-0022024-02-09T00:00:002024-02-09T00:00:00Surveys and Questionnaires25.539491770574953e-0022023-08-29T00:00:002023-11-03T00:00:00Quality of Life14.365397852428218e-0022023-11-03T00:00:002023-11-03T00:00:00Arthralgia13.713777717489973e-0022023-08-29T00:00:002023-08-29T00:00:00Psychometrics12.510495299432836e-0022023-08-29T00:00:002023-08-29T00:00:00Pain Measurement12.415769979421794e-0022023-08-29T00:00:002023-08-29T00:00:00Pain11.770558746985215e-0022023-08-29T00:00:002023-08-29T00:00:00Machine Learning11.754074456123456e-0022024-02-09T00:00:002024-02-09T00:00:00Female21.634934398631546e-0022023-08-29T00:00:002023-11-03T00:00:00Reproducibility of Results11.411069778639362e-0022023-08-29T00:00:002023-08-29T00:00:00Male11.385361699055709e-0022023-11-03T00:00:002023-11-03T00:00:00Humans31.369346983025163e-0022023-08-29T00:00:002024-02-09T00:00:00Prognosis11.211818010849989e-0022024-02-09T00:00:002024-02-09T00:00:00Risk Factors17.741368794611068e-0032024-02-09T00:00:002024-02-09T00:00:00Michael M. Alper, M.D.MichaelAlper

Boston Ivf-the Waltham Center40 Second AvenueSuite 300Waltham, MA 02451781/434-650142.39584860000000-71.26423510000000

1BIDMCBeth Israel Deaconess Medical CenterObstetrics Gynecology & Repro. Bio.Associate Professor of Obstetrics, Gynecology and Reproductive Biology, Part-timeAssociate Professorhttp://www.ncbi.nlm.nih.gov/pubmed/41680481Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization. Nat Med. 2026 Mar; 32(3):906-914.Mutlu BR, Civale SC, Diettrich J, Gupta N, Barber T, Sayare M, Penzias AS, Alper MM, Toth TL, Kapur R, Toner M, Sakkas D, Ozkumur E. Nat Med2026 Mar32(3):906-914http://www.ncbi.nlm.nih.gov/pubmed/41160954Response to: Representation of study in recent RBMO Commentary. Reprod Biomed Online. 2025 Dec; 51(6):105338.Garcia-Velasco JA, Alper M, Capalbo A, Casper R, Fatemi H, Molinaro T, Ubaldi F, Pellicer A. Reprod Biomed Online2025 Dec51(6):105338http://www.ncbi.nlm.nih.gov/pubmed/40712966Achieving two live births from one ovarian stimulation cycle: the one-and-done approach revisited. Fertil Steril. 2026 Jan; 125(1):73-82.Huttler A, Duvall D, Sakkas D, Heyward Q, Sabbagh R, Alper M, Vaughan D. Fertil Steril2026 Jan125(1):73-82http://www.ncbi.nlm.nih.gov/pubmed/39579615Private versus funded infertility care: not a challenge but a call for cooperation. Reprod Biomed Online. 2025 01; 50(1):104694.Garcia-Velasco JA, Alper M, Capalbo A, Casper R, Fatemi H, Molinaro T, Ubaldi F, Pellicer A. Reprod Biomed Online2025 0150(1):104694http://www.ncbi.nlm.nih.gov/pubmed/33812650Validation study of the Access antimüllerian hormone assay for the prediction of poor ovarian response to controlled ovarian stimulation. Fertil Steril. 2021 08; 116(2):575-582.Baker VL, Glassner MJ, Doody K, Schnell VL, Gracia C, Shin SS, Behera MA, Le Saint CM, Alper MM, Pavone ME, Zbella EA, Coddington CC, Marshall LA, Feinberg RF, Cooper AR, Straseski JA, Broyles DL. Fertil Steril2021 08116(2):575-582http://www.ncbi.nlm.nih.gov/pubmed/34223253Economic evaluation of highly purified human menotropin or recombinant follicle-stimulating hormone for controlled ovarian stimulation in high-responder patients: analysis of the Menopur in Gonadotropin-releasing Hormone Antagonist Single Embryo Transfer-High Responder (MEGASET-HR) trial. F S Rep. 2020 Dec; 1(3):257-263.Robins JC, Khair AF, Widra EA, Alper MM, Nelson WW, Foster ED, Sinha A, Ando M, Heiser PW, Daftary GS. F S Rep2020 Dec1(3):257-263http://www.ncbi.nlm.nih.gov/pubmed/33279419A multi-centre international study of salivary hormone oestradiol and progesterone measurements in ART monitoring. Reprod Biomed Online. 2021 Feb; 42(2):421-428.Sakkas D, Howles CM, Atkinson L, Borini A, Bosch EA, Bryce C, Cattoli M, Copperman AB, de Bantel AF, French B, Gerris J, Granger SW, Grzegorczyk-Martin V, Lee JA, Levy MJ, Matin MJ, Somers S, Widra EA, Alper MM. Reprod Biomed Online2021 Feb42(2):421-428http://www.ncbi.nlm.nih.gov/pubmed/30388228Types and frequency of non-conformances in an IVF laboratory. Hum Reprod. 2018 12 01; 33(12):2196-2204.Sakkas D, Barrett CB, Alper MM. Hum Reprod2018 12 0133(12):2196-2204http://www.ncbi.nlm.nih.gov/pubmed/31367289Correlation between sonographic follow-up of follicular growth, serum and salivary estradiol in women undergoing controlled ovarian stimulation (IVF/ICSI). Facts Views Vis Obgyn. 2018 Dec; 10(4):173-179.Rottiers AS, Dalewyn L, Somers S, Alper MM, Sakkas D, Gerris J. Facts Views Vis Obgyn2018 Dec10(4):173-179http://www.ncbi.nlm.nih.gov/pubmed/29960708Multicenter evaluation of the Access AMH antimüllerian hormone assay for the prediction of antral follicle count and poor ovarian response to controlled ovarian stimulation. Fertil Steril. 2018 08; 110(3):506-513.e3.Baker VL, Gracia C, Glassner MJ, Schnell VL, Doody K, Coddington CC, Shin SS, Marshall LA, Alper MM, Morales AJ, Pavone ME, Behera MA, Zbella EA, Shapiro BS, Straseski JA, Broyles DL. Fertil Steril2018 08110(3):506-513.e3http://www.ncbi.nlm.nih.gov/pubmed/28169189Ovarian stimulation protocols for IVF: is more better than less? Reprod Biomed Online. 2017 Apr; 34(4):345-353.Alper MM, Fauser BC. Reprod Biomed Online2017 Apr34(4):345-353http://www.ncbi.nlm.nih.gov/pubmed/27916206How many oocytes are optimal to achieve multiple live births with one stimulation cycle? The one-and-done approach. Fertil Steril. 2017 02; 107(2):397-404.e3.Vaughan DA, Leung A, Resetkova N, Ruthazer R, Penzias AS, Sakkas D, Alper MM. Fertil Steril2017 02107(2):397-404.e3http://www.ncbi.nlm.nih.gov/pubmed/25226857When is clomiphene or gonadotropin intrauterine insemination futile? Results of the Fast Track and Standard Treatment Trial and the Forty and Over Treatment Trial, two prospective randomized controlled trials. Fertil Steril. 2014 Nov; 102(5):1331-1337.e1.Kaser DJ, Goldman MB, Fung JL, Alper MM, Reindollar RH. Fertil Steril2014 Nov102(5):1331-1337.e1http://www.ncbi.nlm.nih.gov/pubmed/24796764A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T). Fertil Steril. 2014 Jun; 101(6):1574-81.e1-2.Goldman MB, Thornton KL, Ryley D, Alper MM, Fung JL, Hornstein MD, Reindollar RH. Fertil Steril2014 Jun101(6):1574-81.e1-2http://www.ncbi.nlm.nih.gov/pubmed/24112531Experience with ISO quality control in assisted reproductive technology. Fertil Steril. 2013 Dec; 100(6):1503-8.Alper MM. Fertil Steril2013 Dec100(6):1503-8http://www.ncbi.nlm.nih.gov/pubmed/23932818Acupuncture - placebo? Fertil Steril. 2013 Oct; 100(4):e21.Domar AD, Alper MM. Fertil Steril2013 Oct100(4):e21http://www.ncbi.nlm.nih.gov/pubmed/21982228Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 2011 Oct 04; 9(4):293-4.Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Cell Stem Cell2011 Oct 049(4):293-4http://www.ncbi.nlm.nih.gov/pubmed/21496800Impact of a group mind/body intervention on pregnancy rates in IVF patients. Fertil Steril. 2011 Jun; 95(7):2269-73.Domar AD, Rooney KL, Wiegand B, Orav EJ, Alper MM, Berger BM, Nikolovski J. Fertil Steril2011 Jun95(7):2269-73http://www.ncbi.nlm.nih.gov/pubmed/21575846Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF. Reprod Biomed Online. 2011 Feb; 22 Suppl 1:S23-31.Fauser BC, Alper MM, Ledger W, Schoolcraft WB, Zandvliet A, Mannaerts BM. Reprod Biomed Online2011 Feb22 Suppl 1:S23-31http://www.ncbi.nlm.nih.gov/pubmed/20843746Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF. Reprod Biomed Online. 2010 Nov; 21(5):593-601.Fauser BC, Alper MM, Ledger W, Schoolcraft WB, Zandvliet A, Mannaerts BM. Reprod Biomed Online2010 Nov21(5):593-601http://www.ncbi.nlm.nih.gov/pubmed/19591985A prospective investigation into the reasons why insured United States patients drop out of in vitro fertilization treatment. Fertil Steril. 2010 Sep; 94(4):1457-1459.Domar AD, Smith K, Conboy L, Iannone M, Alper M. Fertil Steril2010 Sep94(4):1457-1459http://www.ncbi.nlm.nih.gov/pubmed/19531445A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial. Fertil Steril. 2010 Aug; 94(3):888-99.Reindollar RH, Regan MM, Neumann PJ, Levine BS, Thornton KL, Alper MM, Goldman MB. Fertil Steril2010 Aug94(3):888-99http://www.ncbi.nlm.nih.gov/pubmed/20485578Ovarian hyperstimulation syndrome: current views on pathophysiology, risk factors, prevention, and management. J Exp Clin Assist Reprod. 2009 Jun 10; 6:3.Alper MM, Smith LP, Sills ES. J Exp Clin Assist Reprod2009 Jun 106:3http://www.ncbi.nlm.nih.gov/pubmed/19487066Ovarian reserve screening in infertility: practical applications and theoretical directions for research. Eur J Obstet Gynecol Reprod Biol. 2009 Sep; 146(1):30-6.Sills ES, Alper MM, Walsh AP. Eur J Obstet Gynecol Reprod Biol2009 Sep146(1):30-6http://www.ncbi.nlm.nih.gov/pubmed/18976762Patients with severe ovarian hyperstimulation syndrome can be managed safely with aggressive outpatient transvaginal paracentesis. Fertil Steril. 2009 Dec; 92(6):1953-9.Smith LP, Hacker MR, Alper MM. Fertil Steril2009 Dec92(6):1953-9http://www.ncbi.nlm.nih.gov/pubmed/18647398Assessment of the biopotency of follitropin alfa and lutropin alfa combined in one injection: a comparative trial in Sprague-Dawley rats. Reprod Biol Endocrinol. 2008 Jul 22; 6:31.Alper M, Meyer R, Dekkers C, Ezcurra D, Schertz J, Kelly E. Reprod Biol Endocrinol2008 Jul 226:31http://www.ncbi.nlm.nih.gov/pubmed/18339377Oral contraceptive pretreatment in women undergoing controlled ovarian stimulation in ganirelix acetate cycles may, for a subset of patients, be associated with low serum luteinizing hormone levels, reduced ovarian response to gonadotropins, and early pregnancy loss. Fertil Steril. 2009 May; 91(5):1963-5.Meldrum DR, Scott RT, Levy MJ, Alper MM, Noyes N. Fertil Steril2009 May91(5):1963-5http://www.ncbi.nlm.nih.gov/pubmed/18314118The impact of acupuncture on in vitro fertilization outcome. Fertil Steril. 2009 Mar; 91(3):723-6.Domar AD, Meshay I, Kelliher J, Alper M, Powers RD. Fertil Steril2009 Mar91(3):723-6http://www.ncbi.nlm.nih.gov/pubmed/17482171Pregnancy loss in the first in vitro fertilization cycle is not predictive of subsequent delivery in women over 40 years. Fertil Steril. 2008 Feb; 89(2):364-7.Sneeringer R, Klipstein S, Ryley DA, Alper MM, Reindollar RH. Fertil Steril2008 Feb89(2):364-7http://www.ncbi.nlm.nih.gov/pubmed/16359993Staff management in the in vitro fertilization laboratory. Fertil Steril. 2005 Dec; 84(6):1786-8.Keck C, Fischer R, Baukloh V, Alper M. Fertil Steril2005 Dec84(6):1786-8http://www.ncbi.nlm.nih.gov/pubmed/16084887One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above. Fertil Steril. 2005 Aug; 84(2):435-45.Klipstein S, Regan M, Ryley DA, Goldman MB, Alper MM, Reindollar RH. Fertil Steril2005 Aug84(2):435-45http://www.ncbi.nlm.nih.gov/pubmed/15482776A mesothelial cyst of the round ligament presenting as an inguinal hernia after gonadotropin stimulation for in vitro fertilization. Fertil Steril. 2004 Oct; 82(4):944-6.Ryley DA, Moorman DW, Hecht JL, Alper MM. Fertil Steril2004 Oct82(4):944-6http://www.ncbi.nlm.nih.gov/pubmed/15066443Variations in individual physician success rates within an in vitro fertilization program might be due to patient demographics. Fertil Steril. 2004 Apr; 81(4):944-6.Lalwani S, Timmreck L, Friedman R, Penzias A, Alper M, Reindollar RH. Fertil Steril2004 Apr81(4):944-6http://www.ncbi.nlm.nih.gov/pubmed/15037393In vitro fertilization outcomes: why doesn't anyone get it? Fertil Steril. 2004 Mar; 81(3):514-6, discussion 526.Alper MM. Fertil Steril2004 Mar81(3):514-6, discussion 526http://www.ncbi.nlm.nih.gov/pubmed/15037431Initiation of the gonadotropin-releasing hormone antagonist ganirelix for in vitro fertilization cycles in which the lead follicle is >14 mm. Fertil Steril. 2004 Mar; 81(3):714-5.Klipstein S, Reindollar RH, Regan MM, Alper MM. Fertil Steril2004 Mar81(3):714-5http://www.ncbi.nlm.nih.gov/pubmed/12735861Luteal support with vaginal micronized progesterone gel in assisted reproduction. Reprod Biomed Online. 2003 Apr-May; 6(3):287-95.Penzias AS, Alper MM. Reprod Biomed Online2003 Apr-May6(3):287-95http://www.ncbi.nlm.nih.gov/pubmed/11756353Is your IVF programme good? Hum Reprod. 2002 Jan; 17(1):8-10.Alper MM, Brinsden PR, Fischer R, Wikland M. Hum Reprod2002 Jan17(1):8-10http://www.ncbi.nlm.nih.gov/pubmed/11730747Gender bias in the disposition of frozen embryos. Fertil Steril. 2001 Dec; 76(6):1181-4.Klipstein S, Reindollar RH, Regan MM, Alper MM. Fertil Steril2001 Dec76(6):1181-4http://www.ncbi.nlm.nih.gov/pubmed/11278206To blastocyst or not to blastocyst? That is the question. Hum Reprod. 2001 Apr; 16(4):617-9.Alper MM, Brinsden P, Fischer R, Wikland M. Hum Reprod2001 Apr16(4):617-9http://www.ncbi.nlm.nih.gov/pubmed/9673880Multivariate analysis of factors predictive of successful live births in in vitro fertilization (IVF) suggests strategies to improve IVF outcome. J Assist Reprod Genet. 1998 Jul; 15(6):365-71.Minaretzis D, Harris D, Alper MM, Mortola JF, Berger MJ, Power D. J Assist Reprod Genet1998 Jul15(6):365-71http://www.ncbi.nlm.nih.gov/pubmed/7589673Sperm morphology and in vitro fertilization outcome: a direct comparison of World Health Organization and strict criteria methodologies. Fertil Steril. 1995 Dec; 64(6):1177-82.Morgentaler A, Fung MY, Harris DH, Powers RD, Alper MM. Fertil Steril1995 Dec64(6):1177-82http://www.ncbi.nlm.nih.gov/pubmed/7750601Success rates with gamete intrafallopian transfer and in vitro fertilization in women of advanced maternal age. Fertil Steril. 1995 Jun; 63(6):1278-83.Bopp BL, Alper MM, Thompson IE, Mortola J. Fertil Steril1995 Jun63(6):1278-83http://www.ncbi.nlm.nih.gov/pubmed/7755066Gonadotropin-releasing hormone antagonist versus agonist administration in women undergoing controlled ovarian hyperstimulation: cycle performance and in vitro steroidogenesis of granulosa-lutein cells. Am J Obstet Gynecol. 1995 May; 172(5):1518-25.Minaretzis D, Alper MM, Oskowitz SP, Lobel SM, Mortola JF, Pavlou SN. Am J Obstet Gynecol1995 May172(5):1518-25http://www.ncbi.nlm.nih.gov/pubmed/7890077Safety of a freestanding surgical unit for the assisted reproductive technologies. Fertil Steril. 1995 Apr; 63(4):874-9.Oskowitz SP, Berger MJ, Mullen L, Smalky M, Alper M, Thompson I. Fertil Steril1995 Apr63(4):874-9http://www.ncbi.nlm.nih.gov/pubmed/7606153Relationship between urinary estrone conjugates as measured by enzyme immunoassay and serum estradiol in women receiving gonadotropins for in vitro fertilization. J Assist Reprod Genet. 1994 Sep; 11(8):405-8.Alper MM, Halvorson L, Lasley B, Mortola J. J Assist Reprod Genet1994 Sep11(8):405-8http://www.ncbi.nlm.nih.gov/pubmed/8405537Fertility and the use of assisted reproductive techniques in the adult male exstrophy/epispadias patient. Fertil Steril. 1993 Oct; 60(4):733-6.Bastuba MD, Alper MM, Oates RD. Fertil Steril1993 Oct60(4):733-6http://www.ncbi.nlm.nih.gov/pubmed/1382476Comparison of pregnancy rates following gamete intrafallopian transfer (GIFT) under general anesthesia with thiopental sodium or propofol. J Clin Anesth. 1992 Sep-Oct; 4(5):394-8.Pierce ET, Smalky M, Alper MM, Hunter JA, Amrhein RL, Pierce EC. J Clin Anesth1992 Sep-Oct4(5):394-8http://www.ncbi.nlm.nih.gov/pubmed/1348731Laparoscopic salpingectomy using conventional laparoscopy equipment. Int J Fertil. 1992 Jan-Feb; 37(1):26-8.Alper MM, Sperling A, Penzias AS. Int J Fertil1992 Jan-Feb37(1):26-8http://www.ncbi.nlm.nih.gov/pubmed/1757741Comparison of unilateral and bilateral tubal transfer in gamete intrafallopian transfer (GIFT). J In Vitro Fert Embryo Transf. 1991 Oct; 8(5):276-8.Penzias AS, Alper MM, Oskowitz SP, Berger MJ, Thompson IE. J In Vitro Fert Embryo Transf1991 Oct8(5):276-8http://www.ncbi.nlm.nih.gov/pubmed/1899394Gamete intrafallopian transfer: assessment of the optimal number of oocytes to transfer. Fertil Steril. 1991 Feb; 55(2):311-3.Penzias AS, Alper MM, Oskowitz SP, Berger MJ, Thompson IE. Fertil Steril1991 Feb55(2):311-3http://www.ncbi.nlm.nih.gov/pubmed/1984225Successful use of gamete intrafallopian transfer does not reverse the decline in fertility in women over 40 years of age. Obstet Gynecol. 1991 Jan; 77(1):37-9.Penzias AS, Thompson IE, Alper MM, Oskowitz SP, Berger MJ. Obstet Gynecol1991 Jan77(1):37-9http://www.ncbi.nlm.nih.gov/pubmed/3290479Pregnancy after gamete intrafallopian transfer in a woman with primary infertility and in utero exposure to diethylstilbestrol. A case report. J Reprod Med. 1988 May; 33(5):489-91.Alper MM, Oskowitz SP, Berger MJ, Thompson IE, Whitmyer J, Powers RD. J Reprod Med1988 May33(5):489-91http://www.ncbi.nlm.nih.gov/pubmed/3595917Comparison of follicular fluid hormones in patients with one or two ovaries participating in a program of in vitro fertilization. Fertil Steril. 1987 Jul; 48(1):94-7.Alper MM, Seibel MM, Oskowitz SP, Taymor ML. Fertil Steril1987 Jul48(1):94-7http://www.ncbi.nlm.nih.gov/pubmed/2950000Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans. Fertil Steril. 1987 Feb; 47(2):255-8.Alper MM, Garner PR. Fertil Steril1987 Feb47(2):255-8http://www.ncbi.nlm.nih.gov/pubmed/3534255Premature ovarian failure. Current concepts. J Reprod Med. 1986 Aug; 31(8):699-708.Alper MM, Garner PR, Seibel MM. J Reprod Med1986 Aug31(8):699-708http://www.ncbi.nlm.nih.gov/pubmed/3014408Pregnancy rates after hysterosalpingography with oil- and water-soluble contrast media. Obstet Gynecol. 1986 Jul; 68(1):6-9.Alper MM, Garner PR, Spence JE, Quarrington AM. Obstet Gynecol1986 Jul68(1):6-9http://www.ncbi.nlm.nih.gov/pubmed/3712361Intractable primary infertility in women exposed to diethylstilbestrol in utero. J Reprod Med. 1986 Apr; 31(4):231-5.Berger MJ, Alper MM. J Reprod Med1986 Apr31(4):231-5http://www.ncbi.nlm.nih.gov/pubmed/3080719Pregnancies after premature ovarian failure. Obstet Gynecol. 1986 Mar; 67(3 Suppl):59S-62S.Alper MM, Jolly EE, Garner PR. Obstet Gynecol1986 Mar67(3 Suppl):59S-62Shttp://www.ncbi.nlm.nih.gov/pubmed/4093705The relationship of semen parameters to fertilization in patients participating in a program of in vitro fertilization. J In Vitro Fert Embryo Transf. 1985 Dec; 2(4):217-23.Alper MM, Lee GS, Seibel MM, Smith D, Oskowitz SP, Ransil BJ, Taymor ML. J In Vitro Fert Embryo Transf1985 Dec2(4):217-23http://www.ncbi.nlm.nih.gov/pubmed/3932102Comparison of follicular response in patients with one or two ovaries in a program of in vitro fertilization. Fertil Steril. 1985 Nov; 44(5):652-5.Alper MM, Seibel MM, Oskowitz SP, Smith BD, Ransil BJ, Taymor ML. Fertil Steril1985 Nov44(5):652-5http://www.ncbi.nlm.nih.gov/pubmed/3158739Coexistence of gonadal dysgenesis and uterine aplasia. A case report. J Reprod Med. 1985 Mar; 30(3):232-4.Alper MM, Garner PR, Spence JE. J Reprod Med1985 Mar30(3):232-4http://www.ncbi.nlm.nih.gov/pubmed/6152991Pulmonary edema associated with ritodrine and dexamethasone treatment of threatened premature labor. A case report. J Reprod Med. 1983 May; 28(5):349-52.Alper M, Cohen WR. J Reprod Med1983 May28(5):349-52Fertilization in Vitro332.763593470469280e+0001985-11-01T00:00:002026-02-12T00:00:00Ovulation Induction142.146867140769937e+0001985-11-01T00:00:002025-07-23T00:00:00Pregnancy Rate131.101479296539202e+0002003-04-01T00:00:002018-12-01T00:00:00Oocyte Retrieval49.641720006506129e-0012016-12-01T00:00:002026-02-12T00:00:00Gonadotropins58.865543292726730e-0011994-09-01T00:00:002017-01-24T00:00:00Pregnancy, Multiple67.706399714668695e-0011983-05-01T00:00:002016-12-01T00:00:00Progesterone46.980018841754235e-0011987-07-01T00:00:002020-10-24T00:00:00Embryo Transfer96.260851483028239e-0011995-06-01T00:00:002025-07-23T00:00:00Infertility, Female116.163118967180825e-0011986-04-01T00:00:002014-04-30T00:00:00Infertility56.007576967180304e-0012009-06-16T00:00:002024-10-28T00:00:00Reproductive Techniques, Assisted55.906425011937682e-0012009-06-16T00:00:002024-10-28T00:00:00Estradiol95.695561224300325e-0011985-11-01T00:00:002020-10-24T00:00:00Laboratories, Hospital15.253897622393677e-0012018-12-01T00:00:002018-12-01T00:00:00Ovarian Follicle74.551697389042376e-0011985-11-01T00:00:002018-06-28T00:00:00Saliva14.521943960176040e-0012020-10-24T00:00:002020-10-24T00:00:00Follicle Stimulating Hormone84.409308869413628e-0011986-03-01T00:00:002014-04-30T00:00:00Family Characteristics13.529924182276243e-0012016-12-01T00:00:002016-12-01T00:00:00Acupuncture Therapy23.507734335074035e-0012008-03-07T00:00:002013-08-08T00:00:00Quality Assurance, Health Care23.217390594088918e-0012005-12-01T00:00:002013-10-07T00:00:00Luteinizing Hormone53.207745250701072e-0011987-02-01T00:00:002008-07-22T00:00:00Gonadotropin-Releasing Hormone43.165229404409425e-0011995-05-01T00:00:002020-10-24T00:00:00Quality Control33.136505236795281e-0012002-01-01T00:00:002013-10-07T00:00:00Pregnancy362.999726360796751e-0011983-05-01T00:00:002026-02-12T00:00:00Live Birth52.894840596022907e-0012005-08-01T00:00:002026-02-12T00:00:00Glycoprotein Hormones, alpha Subunit12.875486812076619e-0012008-07-22T00:00:002008-07-22T00:00:00Specimen Handling12.848346832459131e-0012013-10-07T00:00:002013-10-07T00:00:00Ovarian Hyperstimulation Syndrome12.800480200949663e-0012008-10-31T00:00:002008-10-31T00:00:00Paracentesis12.790940398552060e-0012008-10-31T00:00:002008-10-31T00:00:00Guideline Adherence12.773398993950446e-0012018-12-01T00:00:002018-12-01T00:00:00Ovary72.741356023737680e-0011985-11-01T00:00:002009-05-31T00:00:00Anti-Mullerian Hormone32.613112482933873e-0012009-05-31T00:00:002021-03-31T00:00:00Patient Dropouts12.596927066046033e-0012009-07-09T00:00:002009-07-09T00:00:00Documentation12.498698147050529e-0012013-10-07T00:00:002013-10-07T00:00:00Cryopreservation32.487612122368716e-0012001-12-01T00:00:002025-07-23T00:00:00Medical Errors12.333405394493803e-0012013-10-07T00:00:002013-10-07T00:00:00Follicular Fluid12.270763936584540e-0012026-02-12T00:00:002026-02-12T00:00:00Round Ligament of Uterus12.243984707443902e-0012004-10-01T00:00:002004-10-01T00:00:00Mesothelioma, Cystic12.237231502340076e-0012004-10-01T00:00:002004-10-01T00:00:00Reproductive Medicine12.169375717601382e-0012005-12-01T00:00:002005-12-01T00:00:00Oocytes72.103771116051441e-0011985-11-01T00:00:002026-02-12T00:00:00Staff Development12.022444573535591e-0012005-12-01T00:00:002005-12-01T00:00:00Clomiphene61.925447405777229e-0011985-11-01T00:00:002014-09-16T00:00:00Luteal Phase11.889873187125102e-0012003-04-01T00:00:002003-04-01T00:00:00Blastocyst21.849071251604824e-0012001-04-01T00:00:002026-02-12T00:00:00Fertility31.803727066409935e-0011993-10-01T00:00:002016-12-01T00:00:00Leuprolide31.763108405342601e-0011992-09-01T00:00:002020-10-24T00:00:00Practice Guidelines as Topic11.735956604134961e-0012018-12-01T00:00:002018-12-01T00:00:00Private Sector11.733929603209082e-0012024-10-28T00:00:002024-10-28T00:00:00Microfluidics11.644350952408726e-0012026-02-12T00:00:002026-02-12T00:00:00Embryo, Mammalian21.586155370635519e-0012001-12-01T00:00:002025-07-23T00:00:00Maternal Age41.500461830503993e-0011995-06-01T00:00:002007-05-04T00:00:00Fertility Agents, Female31.495879850780376e-0012009-06-16T00:00:002014-09-16T00:00:00Peritoneal Neoplasms11.379360669627159e-0012004-10-01T00:00:002004-10-01T00:00:00Sperm Injections, Intracytoplasmic11.358363621931818e-0012018-12-01T00:00:002018-12-01T00:00:00Europe21.349471068708153e-0012004-03-01T00:00:002020-10-24T00:00:00Gamete Intrafallopian Transfer71.337825236397205e-0011991-01-01T00:00:001995-06-01T00:00:00Insemination, Artificial21.293497279590403e-0012014-04-30T00:00:002014-09-16T00:00:00Female551.291114850071190e-0011983-05-01T00:00:002026-02-12T00:00:00Infertility, Male31.290847255955255e-0011993-10-01T00:00:002014-04-30T00:00:00Diethylstilbestrol21.288015360705409e-0011986-04-01T00:00:001988-05-01T00:00:00Reproductive Techniques31.253414500135694e-0011988-05-01T00:00:001995-04-01T00:00:00Menopause, Premature21.117138317123952e-0011986-03-01T00:00:001986-08-01T00:00:00Spermatozoa31.063777619686058e-0011985-12-01T00:00:001998-07-01T00:00:00Fallopian Tubes21.049161114935870e-0011991-10-01T00:00:001992-01-01T00:00:00Estrone11.014598475174391e-0011994-09-01T00:00:001994-09-01T00:00:00Birth Rate21.007383234157997e-0012004-04-01T00:00:002025-07-23T00:00:00Clinical Protocols29.908279055488466e-0022009-06-16T00:00:002017-01-24T00:00:00Adult359.907225397957263e-0021983-05-01T00:00:002026-02-12T00:00:00Chorionic Gonadotropin49.520540938640489e-0021986-04-01T00:00:002010-06-30T00:00:00Humans569.380419349577147e-0021983-05-01T00:00:002026-02-12T00:00:00Area Under Curve19.378406472762541e-0022016-12-01T00:00:002016-12-01T00:00:00Oocyte Donation18.582377266797332e-0022011-10-04T00:00:002011-10-04T00:00:00Pregnancy Outcome58.556423836004981e-0021991-10-01T00:00:002008-10-31T00:00:00Follicle Stimulating Hormone, Human18.224444208502113e-0022010-06-30T00:00:002010-06-30T00:00:00Pregnancy, Ectopic18.174101296215953e-0021992-01-01T00:00:001992-01-01T00:00:00ROC Curve28.138835357346878e-0022008-03-12T00:00:002016-12-01T00:00:00World Health Organization17.628601009478415e-0021995-12-01T00:00:001995-12-01T00:00:00Internationality16.991790437523344e-0022013-10-07T00:00:002013-10-07T00:00:00Syringes16.947115510027790e-0022008-07-22T00:00:002008-07-22T00:00:00Prospective Studies96.900818766736007e-0021986-07-01T00:00:002021-03-31T00:00:00Plastics16.864864594601373e-0022008-07-22T00:00:002008-07-22T00:00:00Menopause26.767658479763819e-0021986-03-01T00:00:001986-08-01T00:00:00Insurance16.695344329004822e-0022009-07-09T00:00:002009-07-09T00:00:00Gonadotropins, Pituitary16.641447562993237e-0021987-07-01T00:00:001987-07-01T00:00:00Embryo Loss16.550385837149288e-0022007-05-04T00:00:002007-05-04T00:00:00Acanthosis Nigricans16.515821348171678e-0021987-02-01T00:00:001987-02-01T00:00:00Mind-Body Therapies16.448674522824718e-0022011-04-15T00:00:002011-04-15T00:00:00Linear Models16.413726720670399e-0022016-12-01T00:00:002016-12-01T00:00:00Hirsutism16.375404429052300e-0021987-02-01T00:00:001987-02-01T00:00:00Abortion, Habitual16.335982504409546e-0022007-05-04T00:00:002007-05-04T00:00:00Iodized Oil16.333588168321598e-0021986-07-01T00:00:001986-07-01T00:00:00Hysterosalpingography16.253752822250062e-0021986-07-01T00:00:001986-07-01T00:00:00Dehydroepiandrosterone15.949029848256018e-0021987-02-01T00:00:001987-02-01T00:00:00Contraceptives, Oral15.814119356342367e-0022008-03-12T00:00:002008-03-12T00:00:00Injections15.787328992204972e-0022008-07-22T00:00:002008-07-22T00:00:00Retrospective Studies115.695002356452512e-0021991-02-01T00:00:002025-07-23T00:00:00Gonadal Dysgenesis15.694638610883365e-0021985-03-01T00:00:001985-03-01T00:00:00Ascorbic Acid15.664363484829287e-0022008-07-22T00:00:002008-07-22T00:00:00Vitrification15.559277508474703e-0022025-07-23T00:00:002025-07-23T00:00:00Odds Ratio15.519975762201988e-0022016-12-01T00:00:002016-12-01T00:00:00Young Adult65.491892384911425e-0022009-06-16T00:00:002021-03-31T00:00:00Logistic Models35.458195550791611e-0021998-07-01T00:00:002016-12-01T00:00:00Multivariate Analysis25.445610181840675e-0021998-07-01T00:00:002016-12-01T00:00:00Uterus25.307381796968069e-0021985-03-01T00:00:001986-04-01T00:00:00Prenatal Exposure Delayed Effects25.254341719886094e-0021986-04-01T00:00:001988-05-01T00:00:00Legislation as Topic15.197588390898046e-0022004-03-01T00:00:002004-03-01T00:00:00Stress, Psychological25.150566331374495e-0022009-07-09T00:00:002011-04-15T00:00:00Ritodrine15.088557244549411e-0021983-05-01T00:00:001983-05-01T00:00:00Preimplantation Diagnosis15.017005534881609e-0022025-07-23T00:00:002025-07-23T00:00:00Automation15.003122399124205e-0022026-02-12T00:00:002026-02-12T00:00:00Organ Size14.982947966917142e-0022008-07-22T00:00:002008-07-22T00:00:00Semen14.905399936140106e-0021985-12-01T00:00:001985-12-01T00:00:00Administration, Intravaginal14.837055474608790e-0022003-04-01T00:00:002003-04-01T00:00:00Databases, Factual14.831182742444856e-0022018-12-01T00:00:002018-12-01T00:00:00Vagina14.754325239338839e-0022008-10-31T00:00:002008-10-31T00:00:00Laboratories14.579404383737965e-0022005-12-01T00:00:002005-12-01T00:00:00Laparoscopy24.570994338328156e-0021985-03-01T00:00:001992-01-01T00:00:00Drug Combinations14.528138670006264e-0022008-07-22T00:00:002008-07-22T00:00:00Gels14.524241295634327e-0022003-04-01T00:00:002003-04-01T00:00:00Twins14.465585293051591e-0021983-05-01T00:00:001983-05-01T00:00:00Hernia, Inguinal14.442798016236622e-0022004-10-01T00:00:002004-10-01T00:00:00Obstetric Labor, Premature14.435570993525515e-0021983-05-01T00:00:001983-05-01T00:00:00United States44.428087083446661e-0022004-03-01T00:00:002020-10-24T00:00:00Divorce14.390974848671994e-0022001-12-01T00:00:002001-12-01T00:00:00Tissue Donors14.325860163661074e-0022011-10-04T00:00:002011-10-04T00:00:00Lab-On-A-Chip Devices14.209081379100257e-0022026-02-12T00:00:002026-02-12T00:00:00Outpatients14.193448061599335e-0022008-10-31T00:00:002008-10-31T00:00:00Sperm Count24.174711163264751e-0021985-12-01T00:00:001995-12-01T00:00:00Granulosa Cells24.159196897895996e-0021986-03-01T00:00:001995-05-01T00:00:00Workforce14.125973143624234e-0022005-12-01T00:00:002005-12-01T00:00:00Medical Audit14.037856704879116e-0022002-01-01T00:00:002002-01-01T00:00:00Sperm Motility24.037095970591006e-0021985-12-01T00:00:001995-12-01T00:00:00Pulmonary Edema14.027706237910658e-0021983-05-01T00:00:001983-05-01T00:00:00Data Collection14.008748137041893e-0022009-07-09T00:00:002009-07-09T00:00:00Delivery, Obstetric13.940271189986443e-0022007-05-04T00:00:002007-05-04T00:00:00Treatment Outcome83.903583907512634e-0021998-07-01T00:00:002016-12-01T00:00:00Testosterone23.802784555812185e-0021987-02-01T00:00:001987-07-01T00:00:00Inhibins23.734846814683623e-0022009-05-31T00:00:002010-06-30T00:00:00Demography13.726815517910348e-0022004-04-01T00:00:002004-04-01T00:00:00Amenorrhea33.546243562949678e-0021985-03-01T00:00:001986-08-01T00:00:00Patients13.374929404830288e-0022004-04-01T00:00:002004-04-01T00:00:00Ultrasonography33.357276335359079e-0021985-03-01T00:00:002009-05-31T00:00:00Rats, Sprague-Dawley13.271650070860493e-0022008-07-22T00:00:002008-07-22T00:00:00Death13.253294236564162e-0022001-12-01T00:00:002001-12-01T00:00:00Chi-Square Distribution23.183413491885677e-0021994-09-01T00:00:002011-04-15T00:00:00Drug Administration Schedule23.120459359204931e-0022014-04-30T00:00:002014-09-16T00:00:00Prevalence23.065679170672775e-0022009-07-09T00:00:002014-09-16T00:00:00Statistics, Nonparametric13.046406402711739e-0022001-12-01T00:00:002001-12-01T00:00:00Anxiety23.042918410008661e-0022008-03-07T00:00:002009-07-09T00:00:00Luteal Cells12.910468700192868e-0021995-05-01T00:00:001995-05-01T00:00:00International Cooperation12.898557867496779e-0022002-01-01T00:00:002002-01-01T00:00:00Dexamethasone12.882485891306286e-0021983-05-01T00:00:001983-05-01T00:00:00Time Factors62.830845870790085e-0021983-05-01T00:00:002014-04-30T00:00:00Surgicenters12.794584663708240e-0021995-04-01T00:00:001995-04-01T00:00:00Rats22.791041581952980e-0021986-03-01T00:00:002008-07-22T00:00:00Pregnancy, High-Risk12.715673359180057e-0021995-06-01T00:00:001995-06-01T00:00:00Menotropins32.644371943671958e-0021985-11-01T00:00:001992-09-01T00:00:00Time-to-Pregnancy12.600804155219795e-0022014-04-30T00:00:002014-04-30T00:00:00Epispadias12.534327590364631e-0021993-10-01T00:00:001993-10-01T00:00:00Patient Education as Topic12.477356261343234e-0022004-03-01T00:00:002004-03-01T00:00:00Predictive Value of Tests22.458235042937113e-0022018-06-28T00:00:002021-03-31T00:00:00Insulin Resistance12.431667248935820e-0021987-02-01T00:00:001987-02-01T00:00:00Severity of Illness Index22.407833542692486e-0021983-05-01T00:00:002008-10-31T00:00:00Contrast Media12.406421110367368e-0021986-07-01T00:00:001986-07-01T00:00:00Thiopental12.384128251767083e-0021992-09-01T00:00:001992-09-01T00:00:00Insurance Coverage12.329567184227221e-0022004-03-01T00:00:002004-03-01T00:00:00Male112.301948721997572e-0021985-12-01T00:00:002014-04-30T00:00:00Laparoscopes12.289988037156063e-0021992-01-01T00:00:001992-01-01T00:00:00Anesthesia, Intravenous12.249827991610618e-0021992-09-01T00:00:001992-09-01T00:00:00Insurance, Health12.197523588856654e-0022004-03-01T00:00:002004-03-01T00:00:00Menstrual Cycle12.191555172387016e-0021995-05-01T00:00:001995-05-01T00:00:00Stem Cell Research12.167042613354329e-0022011-10-04T00:00:002011-10-04T00:00:00Immunoassay12.096446979286839e-0021994-09-01T00:00:001994-09-01T00:00:00Safety12.050008152079544e-0021995-04-01T00:00:001995-04-01T00:00:00Surveys and Questionnaires22.021817659496449e-0022008-03-07T00:00:002009-07-09T00:00:00Boston21.950666916675888e-0022011-04-15T00:00:002014-04-30T00:00:00Hospitalization21.940246071426892e-0021995-04-01T00:00:002008-10-31T00:00:00Recombinant Proteins21.934966521181707e-0022008-03-12T00:00:002010-06-30T00:00:00Clinical Competence11.890997937859577e-0022005-12-01T00:00:002005-12-01T00:00:00Diagnosis, Differential11.887841066946220e-0022004-10-01T00:00:002004-10-01T00:00:00Patient Satisfaction11.855052219832482e-0022002-01-01T00:00:002002-01-01T00:00:00Creatinine11.816057537131726e-0021994-09-01T00:00:001994-09-01T00:00:00Estrogens21.794877364142477e-0021985-03-01T00:00:001986-03-01T00:00:00Sex Factors11.685644791899927e-0022001-12-01T00:00:002001-12-01T00:00:00Gravidity11.643033893231163e-0022007-05-04T00:00:002007-05-04T00:00:00Urinary Bladder11.627138789962675e-0021993-10-01T00:00:001993-10-01T00:00:00Propofol11.588359171021700e-0021992-09-01T00:00:001992-09-01T00:00:00Calibration11.578345130731645e-0022009-06-16T00:00:002009-06-16T00:00:00Embryo Implantation11.517511988184765e-0022008-03-12T00:00:002008-03-12T00:00:00Dehydroepiandrosterone Sulfate11.508863600881825e-0021987-02-01T00:00:001987-02-01T00:00:00Anovulation11.499878583268380e-0021986-04-01T00:00:001986-04-01T00:00:00Physicians11.499708956465890e-0022004-04-01T00:00:002004-04-01T00:00:00Guidelines as Topic11.390296939064058e-0022011-10-04T00:00:002011-10-04T00:00:00Prolactin11.377504729144421e-0021987-02-01T00:00:001987-02-01T00:00:00Turner Syndrome11.366058937629621e-0021986-03-01T00:00:001986-03-01T00:00:00Ultrasonics11.346454967485314e-0021985-11-01T00:00:001985-11-01T00:00:00Hyperinsulinism11.287703430016517e-0021987-02-01T00:00:001987-02-01T00:00:00Glucose Tolerance Test11.269974428869041e-0021987-02-01T00:00:001987-02-01T00:00:00Central Venous Pressure11.243104063544314e-0021983-05-01T00:00:001983-05-01T00:00:00Abortion, Spontaneous11.208736870510694e-0022008-03-12T00:00:002008-03-12T00:00:00Furosemide11.168327753407203e-0021983-05-01T00:00:001983-05-01T00:00:00Combined Modality Therapy11.155972577653273e-0022014-04-30T00:00:002014-04-30T00:00:00Middle Aged61.142881655228086e-0021991-01-01T00:00:002021-03-31T00:00:00Random Allocation11.137364744813288e-0021986-07-01T00:00:001986-07-01T00:00:00Water-Electrolyte Balance11.124524891391667e-0021983-05-01T00:00:001983-05-01T00:00:00Patient Selection11.094141631904982e-0022014-04-30T00:00:002014-04-30T00:00:00Sensitivity and Specificity11.019523398267910e-0021995-12-01T00:00:001995-12-01T00:00:00Age Factors29.873038141444782e-0031991-01-01T00:00:002014-04-30T00:00:00Risk Factors39.799390561797988e-0031983-05-01T00:00:002014-09-16T00:00:00Animals29.115168882590105e-0031986-03-01T00:00:002008-07-22T00:00:00Sperm-Ovum Interactions19.044333064816411e-0031998-07-01T00:00:001998-07-01T00:00:00Fluid Therapy19.019298724608080e-0031983-05-01T00:00:001983-05-01T00:00:00Infusions, Intravenous18.871993416772415e-0031983-05-01T00:00:001983-05-01T00:00:00Hodgkin Disease18.689075602112191e-0031986-03-01T00:00:001986-03-01T00:00:00Endometriosis18.208806820294384e-0031986-04-01T00:00:001986-04-01T00:00:00Uterine Neoplasms17.791738655466770e-0031986-04-01T00:00:001986-04-01T00:00:00Cross-Sectional Studies17.766466206741687e-0032018-06-28T00:00:002018-06-28T00:00:00Biomarkers17.572579106793389e-0032018-06-28T00:00:002018-06-28T00:00:00Emotions17.431207621448800e-0032008-03-07T00:00:002008-03-07T00:00:00Health Care Costs17.368360183733074e-0032009-06-16T00:00:002009-06-16T00:00:00Prognosis27.304132023916377e-0031986-04-01T00:00:002007-05-04T00:00:00Monitoring, Physiologic17.274523912866596e-0031983-05-01T00:00:001983-05-01T00:00:00Likelihood Functions17.080835623360030e-0031998-07-01T00:00:001998-07-01T00:00:00Adolescent36.976457008555204e-0031985-03-01T00:00:001992-01-01T00:00:00Aromatase16.878302829161320e-0031995-05-01T00:00:001995-05-01T00:00:00Follicular Phase16.793943592319351e-0031995-05-01T00:00:001995-05-01T00:00:00Double-Blind Method16.317025526646422e-0032008-03-07T00:00:002008-03-07T00:00:00Probability16.136000228778084e-0031998-07-01T00:00:001998-07-01T00:00:00Biopsy16.116036422256258e-0031985-03-01T00:00:001985-03-01T00:00:00Insulin15.853467914809198e-0031987-02-01T00:00:001987-02-01T00:00:00Chorionic Gonadotropin, beta Subunit, Human15.814807224619586e-0031992-09-01T00:00:001992-09-01T00:00:00Leukemia, Myeloid, Acute15.026328896990749e-0031986-03-01T00:00:001986-03-01T00:00:00Analysis of Variance14.977575413340991e-0031998-07-01T00:00:001998-07-01T00:00:00Laparotomy14.643412243787112e-0031991-10-01T00:00:001991-10-01T00:00:00Infant, Newborn13.607282937233087e-0031986-03-01T00:00:001986-03-01T00:00:00Incidence13.346959202982399e-0031983-05-01T00:00:001983-05-01T00:00:00Peptide Fragments12.446755893805312e-0031992-09-01T00:00:001992-09-01T00:00:00Cells, Cultured12.396890986805368e-0031995-05-01T00:00:001995-05-01T00:00:00Breast Neoplasms12.229556773807534e-0031986-03-01T00:00:001986-03-01T00:00:00Case-Control Studies12.049608901327114e-0031995-05-01T00:00:001995-05-01T00:00:00Seth Leo Alper, M.D., Ph.D.SethAlper

Beth Israel Deaconess Medical CenterNephrology/Medicine, RN380F99 Brookline AveBoston, MA 02215617/667-044542.34022770000000-71.10585400000000

1BIDMCBeth Israel Deaconess Medical CenterMedicineMolecular MedicineProfessor of MedicineFull ProfessorCo-Principal InvestigatorIntegrated Epithelial and Muscosal BiologyNIH1984-09-302026-03-31LENCER, WAYNE IProject Summary The Harvard Digestive Disease Center (HDDC) is a community of 66 Principal (Full) Members with over $39M annual funding for research directly related to the digestive diseases (this is our Research Base, 31% NIDDK). Center members focus on understanding the cell, tissue, and developmental biology of the mucosal surfaces lining the alimentary tract: this is the Center?s Theme. We address the fundamental mechanisms that underlie normal digestive tract function and the pathogenesis of digestive diseases. Center members work in 4 major Research Areas that address the basis for most diseases of the alimentary tract: n Cell, Developmental, and Stem Cell Biology of the Alimentary Tract; n Innate and Adaptive Mucosal Immunology and Microbial Pathogenesis; n Gut Microbiology and Metabolism; and n Clinical and Translational Human Studies. The Center also includes 55 Affiliate Members (not included in Research Base), who participate in Center activities, use our Cores, but who conduct research that falls outside the theme of the HDDC. Our Members? resources are amplified through services, equipment and training in 3 Biomedical Cores that provide: (Core B) high-resolution microscopy & histopathology, (Core C) diverse technologies to study epithelial cell function & mucosal immunology, and (Core D) technologies in gnotobiotic mice, microbiological and metabolic analyses. Our Cores helped produce 424 original papers. The HDDC Clinical Component supports clinical and translational GI research through subsidized biostatistical and bio-repository services. The Center fosters scientific collaborations through an Enrichment Program reflecting our theme, including an annual symposium, a biennial regional conference Frontiers in Mucosal Immunology, and monthly seminars and workshops focused on young investigators. The HDDC also promotes careers of young scientists through a competitive Pilot-Feasibility Grant Program that has supported 62 investigators since 2006: 92% were awarded major independent funding within 5 years of their award, and all, but one, remain active in digestive diseases-related research. Center Director Wayne Lencer (PI) and Associate Director Richard Blumberg (Co-PI) are highly accomplished physician-scientists, currently Division Chiefs of Pediatric and Adult GI at two major Harvard teaching hospitals, and both are Directors of NIH-funded T32 training programs in Gastroenterology. They are assisted in HDDC leadership by an Executive Committee that includes all Core Directors and Research Area (Affinity-group) Directors, and guided by an External Advisory Board who are all highly accomplished scientists and leaders in GI-related research. The HDDC?s overarching mission is to foster and expand basic and translational science in digestive diseases by n connecting people, n creating opportunity, and n extending resources.Principal InvestigatorMOLECULAR BIOLOGY OF CHLORIDE TRANSPORTNIH1985-07-011990-06-30ALPER, SETH LEOPrincipal InvestigatorMOLECULAR BIOLOGY OF CHLORIDE TRANSPORTNIH1985-07-011990-06-30ALPER, SETH LEOCo-Principal InvestigatorHARVARD CENTER FOR THE STUDY OF KIDNEY DISEASENIH1987-09-011992-07-31BRENNER, BARRY MThis proposal, a collaborative effort involving investigators in the basic and clinical departments at Harvard Medical School (HMS) and four of its major teaching and research affilates (Brigham and Women's Hospital (BWH), Beth Israel Hospital (BIH), Massachusetts General Hospital (MGH), and Joslin Diabetes Center (JDC), seeks support to establish an inter-institutional mulitdisciplinary Kidney Center devoted to a comprehensive understanding of nephropathy in diabetes mellitus. The emphases in this initiative are threefold; 1) to attract new scientific expertise to the intensive study of the basic molecular, cellular and physiological mechanisms of kidney injury in diabetes; 2) to exploit the strengths of the component institutional programs by establishing meaningful and unrestricted inter-institutional, interdisciplinary collaborative research initiatives; and 3) to extend these basic research initiatives to timely and innovative clinical and epidemiological studies of the pathogenesis, treatment and prevention of the nephropathy of this common metabolic disorder. Several specific basic and clinical research studies of diabetic nephropathy are already funded and in progress; the investigators involved in these studies have agreed to share their facilities, approaches and experience and will participate fully in the activities of the proposed Kidney Center, including its planned teaching and research conferences, annual symposia and extensive laboratory and clinical training programs. It is our belief that this proposed Center will foster an acceleration in the acquisition of knowledge in the general area of diabetic and other renal diseases and thereby contribute to improved care of patients.Principal InvestigatorMOLECULAR PHYSIOLOGY OF BAND 3-LIKE PROTEINS OF KIDNEYNIH1991-01-151998-03-31ALPER, SETH LEOSPECIFIC AIMS Our overall objective is to characterize the functional and regulatory properties (common and distinct) of the AE anion exchanger gene family proteins, and to ascribe those properties to defined amino acid residues or domains of the proteins. The proposed experiments are designed to develop an understanding of the mechanisms by which the AE anion exchanger proteins function as regulated ion transporters and interact directly with other proteins. To accomplish these objectives, we propose: 1. To extend the functional analyses of AE1, AE2, and AE3 isoforms in two heterologous expression systems: the Xenopus oocyte and the transiently transfected CHOP cell. 2. To assess the functional and biochemical properties of proteins encoded by defined mutant AE1 cDNAs from patients with hereditary spherocytosis and other erythroid disorders. To mutate AE2 and AE3 in those conserved residues and assess the functional consequences. 3. To define the molecular bases of AE protein regulation by defining the amino acids which mediate various regulatory influences: 4. To ascertain the role of oligomerization state, glycosylation, and fatty acylation on the function and regulation of AE1, AE2, and AE3. 5. To create and select for second-site revertants in loss-of-function mutants, in order to provide information on secondary and tertiary structure of AE proteins. 6. To identify, clone, and characterize proteins which bind to the cytoplasmic domains of AE2 and AE3, and to delineate their binding sites within the AE protein sequences.Principal InvestigatorMOLECULAR PHYSIOLOGY OF BAND 3 LIKE PROTEINS OF KIDNEYNIH1991-01-152008-09-30ALPER, SETH LEOThe AE anion exchanger gene family encodes complex polytopic transmembrane polypeptides that contribute to regulation of intracellular pH (pHi), cell [Cl-], and cell volume through their mediation of electroneutral Cl-/HCO3- exchange. AE-mediated Cl-/HCO3- exchange in polarized epithelia also regulates secretion and reabsorption of proton equivalents and of Cl-. AE-mediated Cl-/HCO3-exchange is thought to be of widespread physiological importance in many cell types. AE1 deficiencies have been particularly associated with hereditary syndromes of spherocytic anemia and of distal renal tubular acidosis. Deficiencies of AE2 or AE3 activity have yet to be defined. Deficiency of a different Cl-/HCO3- exchange activity leads to congenital chloride diarrhea. This competitive continuation grant application proposes to extend past and current experiments by pursuit of the following Specific Aims: 1. Further define structural loci of the regulatory differences among AE isoforms, especially AE1 and AE2. 2. Study natural variants of the AE genes and a different class of anion exchanger for clues about ion translocation pathways and mechanisms. These will include: a. AE1 mutations that cosegregate and likely contribute to heritable distal renal tubular acidosis b. AE polypeptides of genetically related fish that live in river or in soda lake environments c. a more distantly related member of the bicarbonate-transporter superfamily cloned from yeast d. the unrelated sulfate transporter DRA that when mutated results in congenital chloride diarrhea. 3. Further compare and define the mechanisms of electroneutral and electrogenic anion exchange mediated by AE1 E699Q and likely mediated by AE2 E1007Q. 4. Apply directed mutagenesis to define the residues of AE1 and AE2 that contribute to binding and transport of substrate anions and to deduce constraints on secondary and tertiary structure of AE polypeptides. 5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells.Principal InvestigatorCLOTRIMAZOLE THERAPY TO INHIBIT CYST ENLARGEMENT IN PKDNIH1995-09-302000-08-31ALPER, SETH LEOWe propose to examine the novel K channel blocker, clotrimazole (CLT, classically used as an antifungal agent), as a treatment for ADPKD which will act on the secretory, proliferative, and perhaps also signalling phenotypes of the disease. Our previous studies document the properties of CLT which form the basis for this proposal. CLT blocks calcium-gated and some voltage-gated K channels. In sickle erythrocytes, in a mouse model of sickle cell disease, and in sickle cell patients this property prevents K efflux from and dehydration of red cells. CLT blockade of epithelial K recycling at the basolateral membrane can also lead to inhibition of secretagogue-induced short-circuit current in T84 colon carcinoma cells, a model for transepithelial chloride secretion. Lastly, CLT also inhibits cell proliferation in concert with depletion of intracellular Ca stores. Despite these diverse effects, clotrimazole at high oral doses is very well tolerated in mice and normal humans, and well tolerated in humans with sickle cell disease. CLT is off-patent and available at low cost. We will test the following hypothesis: the combined antisecretory and antiproliferative properties of CLT will display characteristics in vitro and in mouse models of PKD which will recommend its consideration for clinical trials in PKD patients who have not yet developed severe renal insufficiency. The specific aims which will subject this hypothesis to experimental test are to: 1. Characterize the ability of CLT to block transepithelial Cl secretion by monolayers and cysts of Type I MDCK, mIMCD-K2, immortalized cpk kidney cells, and ADPKD monolayer in comparison with monolayers and cysts of T84 cells. 2. Characterize the ability of CLT to inhibit proliferation of type I MDCK, mIMCD.K2, cpk, ADPKD, and T84 cells. 3. Characterize the ability of CLT to deplete intracellular Ca stores in Type I MDCK, mIMCD-K2, and cpk cells in comparison with T84 cells. 4. Characterize the ability of CLT to block K channels in Type I MDCK cells, mIMCD-K2 cells, cpk cells, ADPKD cells, and T84 cells. Clone CLT- sensitive K channel(s) from T84, MDCK, and ADPKD cells. 5. Test the ability of oral CLT administration to retard the onset of or to attenuate the severity of polycystic kidney disease in the mouse models jck, cpk, and newly bred strains carrying these genotypes on alternate genetic backgrounds.Principal InvestigatorENDOSTATIN RECEPTOR CDNA CLONING AND IONIC SIGNALINGNIH2000-07-012003-06-30ALPER, SETH LEOThe metazoan circulatory system undergoes development and remodeling through the processes of vasculogenesis, angiogenesis, and arteriogenesis. Angiogenesis is now recognized as a process central to embryonic development, organogenesis and regenerative tissues proliferation, and tumor growth. Enhancement of angiogenesis and vasculogenesis is a current goal in the treatment of ischemic syndromes. Inhibition of angiogenesis, in contrast, is a current goal in the development of new adjunct therapies for cancer and for inflammatory or other benign disorders of hyperproliferation. Folkman and colleagues First postulated and confirmed the necessity of new capillary and microvessel growth for sustained tumor growth beyond a critical, usually nonlethal, mass determined by supply of nutrients and oxygen, and removal of metabolic waste products. Among the many substances Folkman and others subsequently identified as activators and inhibitors of angiogenesis have been proteolytic fragments of proteins with other functions. Objects of much recent attention due to their efficacy and lack of toxicity have been angiostatin, a carboxy-terminal fragment of the procoagulant, fibrinogen, endostatin, a carboxy-terminal fragment of collagen XVIII. Both were originally identified as inhibitors of human and murine tumor growth in mice, and subsequent biological investigation of these molecules has largely focused on their effects on angiogenesis in model system, and their effect on proliferation, cell progression, and apoptosis in tissue culture cells. Additional experiments, have described candidate proteolytic pathways for their biosynthesis and, more recently, structure determinations have been published. Still little studied has been the molecular mechanism by which angiostatin and endostatin interact with endothelial (and perhaps other target) cells and/or with matrix, and the hypothesized signaling cascades triggered by these putative binding interactions. Intracellular ions serve as important cellular second messengers and modulators in a wide variety of cell types and signaling pathways. We have therefore taken this approach to the study of angiogenesis inhibitors, and have discovered that both angiostatin and endostatin trigger acute Ca2+ transients in primary cultures of endothelial cells derived from both large and small-caliber vessels. Such transients are reduced or absent among a small panel of non-endothelial cells. More prolonged exposure to angiostatin and endostatin leads to attenuation of the Ca2+ transients produced by the angiogenic VEGF and FGF-2. In addition, endostatin triggers acute endothelial cell alkalinization. These observations form the basis of this two-year R2I proposal, in which we propose to study in greater detail the ionic signaling pathways elicited in endothelial cells by endostatin and angiostatin, and to use them to expression clone endothelial cell surface receptors for endostatin and, should time permit, for angiostatin as well. We will accomplish these objectives by pursuit of the following Specific Aims: 1. To clone cDNAs encoding endothelial cell receptors for endostatin and (time permitting) angiostatin, using parallel strategies enabled by the ability of these ligands to trigger elevations in intracellular [Ca2+]. 2. To extend our mechanistic characterization of Ca2+ signaling by endostatin and (time permitting) angiostatin, including interactions with endothelial responses to mechanical and aniosmotic perturbations. 3. To determine the molecular basis of pH-signaling by endostatin and (time permitting) angiostatin. Principal InvestigatorSickle Red Cell K+ Transporter Genetics in S. cerevisiaeNIH2001-09-302004-08-31ALPER, SETH LEOThe dehydrated state of the densest erythrocytes in sickle cell disease accelerates deoxygenation-induced polymerization of HbS and consequent, preferential sickling of these dense cells. Activity of the KCC K-Cl cotransporters and the IK1 K(ca) channel mediates nearly all of this dehydration. Pharmacological blockade of these K efflux pathways inhibits cellular dehydration in vitro in mouse models of sickle cell disease, and in patients, may bring clinical benefit. Understanding the mechanisms of ion transport by K-Cl cotransporters and of K ion permeation through the IK1 K(ca) channel is critical to development of safe pharmacological blockers of higher potency and specificity. Structure-function relationship studies using site-directed mutagenesis are underway for KCC K-Cl cotransporters and for the K(ca) IK1. Though productive, these studies are relatively slow. Experiments proposed in this R21 application will utilize strains of S. cerevisiae deficient in high-affinity K ion uptake in order to perform extensive, unbiased structure-function studies of K-Cl cotransporters and the IK1 K(ca) channel. A selection system has already been validated for KCC1. A selection system for IK1 is under development. The proposed experiments will accelerate production and selection of mutants exhibiting loss-of-function and gain-of-function phenotypes. In addition, the system should permit development of a high throughput screen for inhibitors of K ion uptake by these pathways. These goals will be achieved through pursuit of the following Specific Aims: 1) To validate, characterize, and standardize growth rescue of trk1delta/trk2delta S. cerevisiae in nonpermissive growth conditions by expression of cDNAs encoding KCC K-Cl cotransporters. 2) To define structural regions of KCC1 important to ion transport, to cation and anion selectivity, to inhibitor sensitivity, to a recently discovered dominant negative phenotype, and to acute regulation. This will be achieved by saturation mutagenesis of defined subregions of KCC K-Cl cotransporters, and screening mutants for their ability to rescue growth of trk1delta/trk2delta S. cerevisiae. Select mutants will be further studied in Xenopus oocytes and mammalian cells. 3) (Provisional Aim): Time permitting, to improve, validate, and standardize growth rescue of trk1delta/trk2delta S. cerevisiae by expression in nonpermissive conditions of cDNA encoding the mammalian IK1 K(ca) channel. Principal InvestigatorION CHANNEL REGULATION BY THE CYTOPLASMIC TAIL OF PDK1NIH2002-05-012006-04-30ALPER, SETH LEOPolycystic kidney disease is the most common inherited disease secondary to mutation of a single gene. Heterozygous germline mutations in the PKD-1 gene and consequent alterations in the amino acid sequence of the encoded polypeptide, polycystin-1, cosegregate with disease in affected cohorts. Somatic mutations in the second allele may be required for onset of or acceleration of cystogenesis. Cystogenesis is associated with and is thought to require dysregulation of growth control and altered matrix structure. These changes are coupled with conversion from an epithelial phenotype of net reabsorption to one of net secretion. However, despite the phenotypic reproduction of aspects of the human disease in PKD1 -/- mice, the discovery of candidate polycystin-1 binding partners, the discovery of alterations in cell signalling produced by overexpression of a polycystin-1 subdomain, the mechanisms by which polycystin-1 mutations lead to a sustained secretory phenotype accompanied by cyst enlargement remain unknown. Overexpression of part of the C-terminal cytoplasmic domain of polycystin-1 as the fusion protein CD16.7-PKD-1(115-226) upregulates cation channel activity in Xenopus oocytes and in HEK293 cells. We hypothesize that perturbation of this or similar functions accompanies the postulated somatic mutation of the normal germline polycystin-1 allele in the occasional tubular epithelial cells of ADPKD-1 heterozygotes that give rise to cysts. We further hypothesize that this dysregulation (or loss of this function) promotes or causes transition from the normal phenotype of net solute reabsorption to that of net secretion typifying cyst epithelial cells in ADPKD. We propose to extend these studies to polarized normal and ADPKD epithelial cells, and to study regulation of this activity. We will search for novel interacting proteins, and prepare protein suitable for structural analysis.Principal InvestigatorRBC Ion Transporters as Hemoglobinopathy Risk ModifiersNIH2006-06-152011-05-31ALPER, SETH LEOSickle cell disease and thalassemia are characterized by pathological red cell dehydration. The mean corpuscular hemoglobin concentration of sickle erythrocytes critically determines the lag time preceding the rapid phase of deoxygenation-induced polymerization of hemoglobin S. Several erythroid ion transporters and channels are believed on the basis of pharmacological and physiological studies to regulate red cell hemoglobin concentration secondary to regulation of red cell volume. Among these activities already studied as therapeutic targets in sickle cell disease are the KCNN/IK1/SK4 Ca2+-activated K+ channel of intermediate conductance (Gardos channel), several types of KCC K-CI cotransporters, at least two types of erythroid CI- conductance, and at least one type of Ca2+permeable cation conductance. The K-CI cotransporters have also been tested as therapeutic targets for thalassemia. The genes encoding these ion-transporting polypeptides are strong candidate risk modifier genes for the hemoglobinopathies. This application proposes the general hypothesis that genetic modulation of these transporter and channel activities will modulate disease severity in mouse models of hemoglobinopathies. This general hypothesis will be tested by experiments designed to pursue the following Specific Aims: Aim 1. We will test the hypothesis that genetic deficiency of the erythroid IK1/Gardos channel will decrease pathologic red cell dehydration and will ameliorate clinical severity in mouse models of sickle cell disease. Aim 2. We will test the hypothesis that genetic deficiency of erythroid KCC K-CI cotransporters will decrease pathologic red cell dehydration and will ameliorate clinical severity in mouse models of sickle cell disease and of beta-thalassemia intermedia. Aim 3. We will test the hypothesis that combined genetic deficiency of erythroid IK1/Gardos channel and of erythroid KCC K-CI cotransporters will further ameliorate clinical severity in mouse models of sickle cell disease. The proposed experiments will increase understanding of sickle cell disease and thalassemia by providing mouse models for genetic tests of new drug therapies under development for near-term clinical testing. Principal InvestigatorMolecular Mechanism of APOL1 Associated Kidney DiseaseNIH2013-07-032019-01-31POLLAK, MARTIN R.More than 500,000 Americans suffer from end-stage renal disease (ESRD). African Americans develop ESRD at rates 4-5 fold higher than European Americans. Recently we showed that coding sequence variants in the ApolipoproteinL1 (ApoL1) gene, present only in individuals with recent African ancestry, explain a very large proportion of this health disparity. This has now been confirmed by multiple additional studies. ApoL1 variants have a major impact on different types of kidney disease including hypertension-associated ESRD, focal segmental glomerulosclerosis, and HIV-associated nephropathy. Individuals with two variant ApoL1 alleles have a 7-30 fold increased risk for kidney disease. 3.5 million African Americans likely have the high risk ApoL1 genotype. African Americans without two variant alleles have minimal excess risk. At present, little is known about the biology of ApoL1 or its rol in the kidney. ApoL1 has a defined role in resistance to trypanosomes, and the G1 and G2 variants appear to have become common in Africa because they confer protection against the forms of trypanosomes that cause African Sleeping Sickness. Here, our goal is to elucidate the function of ApoL1 and its role in causing human kidney disease in order to understand the biological mechanisms underlying this large disparity in kidney disease risk. ApoL1 is a Bcl2 family member with a BH3-only domain, suggesting a possible role in apoptosis. Our initial experiments in oocytes lead us to believe that this pathway may be an important mechanism of glomerular injury in ApoL1-associated disease. We propose to: 1. Define the cell biology and cell physiology of ApoL1: We will define the basic cellular biology of ApoL1 including biosynthesis, trafficking, ion channel properties, endocytosis, and effects on organellar structure and function. We will compare wild type and renal risk variant ApoL1 biology to understand the mechanisms that lead to kidney disease. 2. Examine specific effects of ApoL1 on apoptosis in podocytes: We hypothesize that ApoL1 risk variants promote podocyte apoptosis via a BH3 domain in the N- terminus and that the renal risk variants enhance ApoL1's pro-apoptotic effects. We will test this hypothesis both in cultured podocytes of different ApoL1 genotypes and by transfecting podocytes with ApoL1 constructs designed to probe the underlying apoptotic mechanisms. 3. Use a zebrafish model to study ApoL1- mediated renal injury in vivo: We will use zebrafish to understand how ApoL1 variants promote glomerular injury. We have demonstrated that the G1 risk variant increases embryonic lethality and causes glomerular pathology, and that wild type ApoL1 can reverse the pathologic phenotype caused by G1. We will examine the effects of heterologous ApoL1 expression in a whole organism using ubiquitous and tissue-specific promoters. We will define the risk variant domains that cause disease and the wild type domains that prevent G1-mediated injury. We will also define the specific interactions between the wild-type, G1, and G2 forms of ApoL1 in vivo. Lastly, we will examine the role of ApoL1 variants in promoting or preventing apoptosis of glomerular cells.http://www.ncbi.nlm.nih.gov/pubmed/41122971Kcnn4/KCa3.1 inhibition blunts polycystic kidney disease progression in mouse models. JCI Insight. 2025 Oct 22; 10(20).Yao G, Kurbegovic A, Parrot C, Foley W, Roman W, Alper SL, Trudel M. 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Brain. 2025 May 13; 148(5):1817-1828.Allington G, Mehta NH, Dennis E, Mekbib KY, Reeves B, Kiziltug E, Chen S, Zhao S, Duy PQ, Saleh M, Ang LC, Fan B, Nelson-Williams C, Moreno-de-Luca A, Haider S, Lifton RP, Alper SL, McGee S, Jin SC, Kahle KT. Brain2025 May 13148(5):1817-1828http://www.ncbi.nlm.nih.gov/pubmed/40324076Single-cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2025 May 13; 122(19):e2412159122.Duy PQ, Kiziltug E, Greenberg ABW, Mehta NH, Hao LT, Fortes C, Mullany S, Fan B, Manichaikul A, Teich AF, Chan D, Alper SL, Hyman BT, Arnold SE, McKhann GM, Frosch MP, Kahle KT. Proc Natl Acad Sci U S A2025 May 13122(19):e2412159122http://www.ncbi.nlm.nih.gov/pubmed/40315599Clinical phenotypes among patients with familial forms of Chiari malformation type 1. J Neurosurg Pediatr. 2025 Jul 01; 36(1):109-118.Mekbib KY, Muñoz W, Allington G, Zhao S, Mehta NH, Fortes C, Shohfi JP, Fan B, Nelson-Williams C, DeSpenza T, Butler WE, Alper SL, Jackson EM, Kahle KT. J Neurosurg Pediatr2025 Jul 0136(1):109-118http://www.ncbi.nlm.nih.gov/pubmed/40294255Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1. Proc Natl Acad Sci U S A. 2025 May 06; 122(18):e2425494122.Ong ST, Nam YW, Nasburg JA, Ramanishka A, Ng XR, Zhuang Z, Goay SSM, Nguyen HM, Singh L, Singh V, Rivera A, Eyster ME, Xu Y, Alper SL, Wulff H, Zhang M, Chandy KG. Proc Natl Acad Sci U S A2025 May 06122(18):e2425494122http://www.ncbi.nlm.nih.gov/pubmed/40275365Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy. Acta Neuropathol Commun. 2025 04 24; 13(1):83.Riccardi V, Viscomi CF, Sandri M, D'Alessandro A, Dzieciatkowska M, Stephenson D, Federti E, Hermann A, Salviati L, Siciliano A, Andolfo I, Alper SL, Ceolan J, Iolascon A, Vattemi G, Danek A, Walker RH, Mensch A, Otto M, Deschauer M, Armbrust M, Beninca' C, Salari V, Fabene P, Peikert K, De Franceschi L. Acta Neuropathol Commun2025 04 2413(1):83http://www.ncbi.nlm.nih.gov/pubmed/40144023Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder. Front Mol Biosci. 2025; 12:1519977.Mao W, Zhang T, Chen H, Barge S, Wang Z, Olumi A, Alper S, Yu W. Front Mol Biosci202512:1519977http://www.ncbi.nlm.nih.gov/pubmed/39989457Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility. JCI Insight. 2025 Feb 24; 10(4).Luo Z, Wu A, Robson S, Alper SL, Yu W. JCI Insight2025 Feb 2410(4)http://www.ncbi.nlm.nih.gov/pubmed/39994410PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nat Neurosci. 2025 Mar; 28(3):536-557.DeSpenza T, Kiziltug E, Allington G, Barson DG, McGee S, O'Connor D, Robert SM, Mekbib KY, Nanda P, Greenberg ABW, Singh A, Duy PQ, Mandino F, Zhao S, Lynn A, Reeves BC, Marlier A, Getz SA, Nelson-Williams C, Shimelis H, Walsh LK, Zhang J, Wang W, Prina ML, OuYang A, Abdulkareem AF, Smith H, Shohfi J, Mehta NH, Dennis E, Reduron LR, Hong J, Butler W, Carter BS, Deniz E, Lake EMR, Constable RT, Sahin M, Srivastava S, Winden K, Hoffman EJ, Carlson M, Gunel M, Lifton RP, Alper SL, Jin SC, Crair MC, Moreno-De-Luca A, Luikart BW, Kahle KT. Nat Neurosci2025 Mar28(3):536-557http://www.ncbi.nlm.nih.gov/pubmed/39680459Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors. J Clin Invest. 2024 Dec 16; 134(24).Bazua-Valenti S, Brown MR, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom EH, Keller KH, Racette M, Dvela-Levitt M, Quintanova C, Demirci H, Sewerin S, Goss AC, Lin J, Yoo H, Vaca Jacome AS, Papanastasiou M, Udeshi N, Carr SA, Himmerkus N, Bleich M, Mutig K, Bachmann S, Halbritter J, Kmoch S, Živná M, Kidd K, Bleyer AJ, Weins A, Alper SL, Shaw JL, Kost-Alimova M, Pablo JLB, Greka A. J Clin Invest2024 Dec 16134(24)http://www.ncbi.nlm.nih.gov/pubmed/38833623TRIM71 mutations cause a neurodevelopmental syndrome featuring ventriculomegaly and hydrocephalus. Brain. 2024 Dec 03; 147(12):4292-4305.Duy PQ, Jux B, Zhao S, Mekbib KY, Dennis E, Dong W, Nelson-Williams C, Mehta NH, Shohfi JP, Juusola J, Allington G, Smith H, Marlin S, Belhous K, Monteleone B, Schaefer GB, Pisarska MD, Vásquez J, Estrada-Veras JI, Keren B, Mignot C, Flore LA, Palafoll IV, Alper SL, Lifton RP, Haider S, Moreno-De-Luca A, Jin SC, Kolanus W, Kahle KT. Brain2024 Dec 03147(12):4292-4305http://www.ncbi.nlm.nih.gov/pubmed/39585978Genetic risk factors for Mesoamerican nephropathy. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2404848121.Friedman DJ, Leone DA, Amador JJ, Kupferman J, Francey LJ, Lopez-Pilarte D, Lau J, Delgado I, Yih WK, Salinas A, Wang M, Genovese G, Shah S, Kelly J, Tattersfield CF, Raines NH, Amador M, Dias L, Pitsillides A, Ramirez-Rubio O, Amador AG, Cortopassi M, Applebaum KM, Alper SL, Banks AS, McClean MD, Leibler JH, Scammell MK, Dupuis J, Brooks DR. Proc Natl Acad Sci U S A2024 Dec 03121(49):e2404848121http://www.ncbi.nlm.nih.gov/pubmed/39536114INF2 mutations cause kidney disease through a gain-of-function mechanism. Sci Adv. 2024 11 15; 10(46):eadr1017.Subramanian B, Williams S, Karp S, Hennino MF, Jacas S, Lee M, Riella CV, Alper SL, Higgs HN, Pollak MR. Sci Adv2024 11 1510(46):eadr1017http://www.ncbi.nlm.nih.gov/pubmed/39554160Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility. bioRxiv. 2024 Oct 29.Luo Z, Wu A, Robson S, Alper S, Yu W. bioRxiv2024 Oct 29http://www.ncbi.nlm.nih.gov/pubmed/39356563Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo. Kidney360. 2024 Nov 01; 5(11):1601-1612.Fan Q, Hadla M, Peterson Z, Nelson G, Ye H, Wang X, Mardirossian JM, Harris PC, Alper SL, Prakash YS, Beyder A, Torres VE, Chebib FT. Kidney3602024 Nov 015(11):1601-1612http://www.ncbi.nlm.nih.gov/pubmed/39303030Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway. Sci Adv. 2024 09 20; 10(38):eadp2221.Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H. Sci Adv2024 09 2010(38):eadp2221http://www.ncbi.nlm.nih.gov/pubmed/39178477Genetics and molecular pathophysiology of normal pressure hydrocephalus. J Neurosurg. 2025 Feb 01; 142(2):346-352.Mehta NH, Maury EA, Buller Z, Duy PQ, Fortes C, Alper SL, Erson-Omay EZ, Kahle KT. J Neurosurg2025 Feb 01142(2):346-352http://www.ncbi.nlm.nih.gov/pubmed/39181397Differing sensitivities to angiotensin converting enzyme inhibition of kidney disease mediated by APOL1 high-risk variants G1 and G2. Kidney Int. 2024 12; 106(6):1072-1085.Sula Karreci E, Jacas S, Donovan O, Pintye D, Wiley N, Zsengeller ZK, Schlondorff J, Alper SL, Friedman DJ, Pollak MR. Kidney Int2024 12106(6):1072-1085http://www.ncbi.nlm.nih.gov/pubmed/38916997Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics. 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FASEB J. 2024 01 31; 38(2):e23416.Barge S, Wu A, Zhang L, Robson SC, Olumi A, Alper SL, Zeidel ML, Yu W. FASEB J2024 01 3138(2):e23416http://www.ncbi.nlm.nih.gov/pubmed/38223928Reduced surface pH and upregulated AE2 anion exchange in SLC26A3-deleted polarized intestinal epithelial cells. Am J Physiol Cell Physiol. 2024 03 01; 326(3):C829-C842.Amiri M, Jiang M, Salari A, Xiu R, Alper SL, Seidler UE. Am J Physiol Cell Physiol2024 03 01326(3):C829-C842http://www.ncbi.nlm.nih.gov/pubmed/37978175Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations. Nat Commun. 2023 11 17; 14(1):7452.Zhao S, Mekbib KY, van der Ent MA, Allington G, Prendergast A, Chau JE, Smith H, Shohfi J, Ocken J, Duran D, Furey CG, Hao LT, Duy PQ, Reeves BC, Zhang J, Nelson-Williams C, Chen D, Li B, Nottoli T, Bai S, Rolle M, Zeng X, Dong W, Fu PY, Wang YC, Mane S, Piwowarczyk P, Fehnel KP, See AP, Iskandar BJ, Aagaard-Kienitz B, Moyer QJ, Dennis E, Kiziltug E, Kundishora AJ, DeSpenza T, Greenberg ABW, Kidanemariam SM, Hale AT, Johnston JM, Jackson EM, Storm PB, Lang SS, Butler WE, Carter BS, Chapman P, Stapleton CJ, Patel AB, Rodesch G, Smajda S, Berenstein A, Barak T, Erson-Omay EZ, Zhao H, Moreno-De-Luca A, Proctor MR, Smith ER, Orbach DB, Alper SL, Nicoli S, Boggon TJ, Lifton RP, Gunel M, King PD, Jin SC, Kahle KT. Nat Commun2023 11 1714(1):7452http://www.ncbi.nlm.nih.gov/pubmed/38034282Challenges to dialysis treatment during the COVID-19 pandemic: a qualitative study of patients' and experts' perspectives. 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Trends Mol Med2023 1229(12):1059-1075http://www.ncbi.nlm.nih.gov/pubmed/37482902Blockade of the mineralocorticoid receptor improves markers of human endothelial cell dysfunction and hematological indices in a mouse model of sickle cell disease. FASEB J. 2023 08; 37(8):e23092.Rivera A, Vega C, Ramos-Rivera A, Maldonado ER, Prado GN, Karnes HE, Fesko YA, Snyder LM, Alper SL, Romero JR. FASEB J2023 0837(8):e23092http://www.ncbi.nlm.nih.gov/pubmed/37059330Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis. Transl Res. 2023 09; 259:28-34.Gebeshuber CA, Daniel-Fischer L, Regele H, Schachner H, Aufricht C, Kornauth C, Ley M, Alper SL, Herzog R, Kratochwill K, Perco P. Transl Res2023 09259:28-34http://www.ncbi.nlm.nih.gov/pubmed/36097331A neural stem cell paradigm of pediatric hydrocephalus. 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Proc Natl Acad Sci U S A. 2014 May 20; 111(20):E2130-9.Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Proc Natl Acad Sci U S A2014 May 20111(20):E2130-9http://www.ncbi.nlm.nih.gov/pubmed/24668450Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Arch. 2014 Aug; 466(8):1605-18.Shmukler BE, Reimold FR, Heneghan JF, Chen C, Zhao T, Paw BH, Alper SL. Pflugers Arch2014 Aug466(8):1605-18http://www.ncbi.nlm.nih.gov/pubmed/24603188Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions. Cell Physiol Biochem. 2014; 33(3):605-20.Sharma AK, Zelikovic I, Alper SL. Cell Physiol Biochem201433(3):605-20http://www.ncbi.nlm.nih.gov/pubmed/24429828Pendrin, a novel transcriptional target of the uroguanylin system. Cell Physiol Biochem. 2013; 32(7):221-37.Rozenfeld J, Tal O, Kladnitsky O, Adler L, Efrati E, Carrithers SL, Alper SL, Zelikovic I. Cell Physiol Biochem201332(7):221-37http://www.ncbi.nlm.nih.gov/pubmed/24029865Association of hypermagnesemia and blood pressure in the critically ill. J Hypertens. 2013 Nov; 31(11):2136-41; discussion 2141.Celi LA, Scott DJ, Lee J, Nelson R, Alper SL, Mukamal KJ, Mark RG, Danziger J. J Hypertens2013 Nov31(11):2136-41; discussion 2141http://www.ncbi.nlm.nih.gov/pubmed/24194990Metastatic infiltrating ductal carcinoma of the breast to the colon: a case report and literature review. Case Rep Gastrointest Med. 2013; 2013:603683.Samo S, Sherid M, Husein H, Sulaiman S, Brower JV, Alper S, Yungbluth M, Vainder JA. Case Rep Gastrointest Med20132013:603683http://www.ncbi.nlm.nih.gov/pubmed/23553550Na+/H+ exchange is inactivated during mouse oocyte meiosis, facilitating glycine accumulation that maintains embryo cell volume. J Cell Physiol. 2013 Oct; 228(10):2042-53.Zhou C, Fitzharris G, Alper SL, Baltz JM. J Cell Physiol2013 Oct228(10):2042-53http://www.ncbi.nlm.nih.gov/pubmed/24051746Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct. JAMA Otolaryngol Head Neck Surg. 2013 Sep; 139(9):907-13.Chattaraj P, Reimold FR, Muskett JA, Shmukler BE, Chien WW, Madeo AC, Pryor SP, Zalewski CK, Butman JA, Brewer CC, Kenna MA, Alper SL, Griffith AJ. JAMA Otolaryngol Head Neck Surg2013 Sep139(9):907-13http://www.ncbi.nlm.nih.gov/pubmed/23973043Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.Shmukler BE, Vandorpe DH, Rivera A, Auerbach M, Brugnara C, Alper SL. Blood Cells Mol Dis2014 Jan52(1):53-4http://www.ncbi.nlm.nih.gov/pubmed/23903370TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis. Kidney Int. 2014 Jan; 85(1):72-81.Xu C, Chang A, Hack BK, Eadon MT, Alper SL, Cunningham PN. Kidney Int2014 Jan85(1):72-81http://www.ncbi.nlm.nih.gov/pubmed/23878365Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. J Physiol. 2013 Oct 15; 591(20):4963-82.Al-Samir S, Papadopoulos S, Scheibe RJ, Meißner JD, Cartron JP, Sly WS, Alper SL, Gros G, Endeward V. J Physiol2013 Oct 15591(20):4963-82http://www.ncbi.nlm.nih.gov/pubmed/25960948SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct. World J Otorhinolaryngol. 2013 May 28; 3(2):26-34.Ito T, Muskett J, Chattaraj P, Choi BY, Lee KY, Zalewski CK, King KA, Li X, Wangemann P, Shawker T, Brewer CC, Alper SL, Griffith AJ. World J Otorhinolaryngol2013 May 283(2):26-34http://www.ncbi.nlm.nih.gov/pubmed/23506885The SLC26 gene family of anion transporters and channels. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):494-515.Alper SL, Sharma AK. Mol Aspects Med2013 Apr-Jun34(2-3):494-515http://www.ncbi.nlm.nih.gov/pubmed/23525530Short-term responses of the kidney to high altitude in mountain climbers. Nephrol Dial Transplant. 2014 Mar; 29(3):497-506.Goldfarb-Rumyantzev AS, Alper SL. Nephrol Dial Transplant2014 Mar29(3):497-506http://www.ncbi.nlm.nih.gov/pubmed/23504232Harnessing red cell membrane pathophysiology towards point-of-care diagnosis for sickle cell disease. J Physiol. 2013 Mar 15; 591(6):1403-4.Alper SL. J Physiol2013 Mar 15591(6):1403-4http://www.ncbi.nlm.nih.gov/pubmed/23482811Strain-specific variations in cation content and transport in mouse erythrocytes. Physiol Genomics. 2013 May 01; 45(9):343-50.Rivera A, Zee RY, Alper SL, Peters LL, Brugnara C. Physiol Genomics2013 May 0145(9):343-50http://www.ncbi.nlm.nih.gov/pubmed/23479567Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 09; 121(19):3925-35, S1-12.Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A. Blood2013 May 09121(19):3925-35, S1-12http://www.ncbi.nlm.nih.gov/pubmed/23481459N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes. Blood Cells Mol Dis. 2013 Jun; 51(1):9-16.Shmukler BE, Hsu A, Alves J, Trudel M, Rust MB, Hubner CA, Rivera A, Alper SL. Blood Cells Mol Dis2013 Jun51(1):9-16http://www.ncbi.nlm.nih.gov/pubmed/23406318Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout. Br J Haematol. 2013 May; 161(4):602-4.Shmukler BE, Mukodzi S, Andres O, Eber S, Alper SL. Br J Haematol2013 May161(4):602-4http://www.ncbi.nlm.nih.gov/pubmed/23418565Transcriptional patterns in peritoneal tissue of encapsulating peritoneal sclerosis, a complication of chronic peritoneal dialysis. PLoS One. 2013; 8(2):e56389.Reimold FR, Braun N, Zsengellér ZK, Stillman IE, Karumanchi SA, Toka HR, Latus J, Fritz P, Biegger D, Segerer S, Alscher MD, Bhasin MK, Alper SL. PLoS One20138(2):e56389http://www.ncbi.nlm.nih.gov/pubmed/23396133Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet. 2013 Mar; 45(3):299-303.Kirby A, Gnirke A, Jaffe DB, Barešová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hulková H, Sovová J, Vylet'al P, Antignac C, Guttman M, Handsaker RE, Perrin D, Steelman S, Sigurdsson S, Scheinman SJ, Sougnez C, Cibulskis K, Parkin M, Green T, Rossin E, Zody MC, Xavier RJ, Pollak MR, Alper SL, Lindblad-Toh K, Gabriel S, Hart PS, Regev A, Nusbaum C, Kmoch S, Bleyer AJ, Lander ES, Daly MJ. Nat Genet2013 Mar45(3):299-303http://www.ncbi.nlm.nih.gov/pubmed/23341620SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2163-8.Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO. Proc Natl Acad Sci U S A2013 Feb 05110(6):2163-8http://www.ncbi.nlm.nih.gov/pubmed/23300922The spectrum of podoplanin expression in encapsulating peritoneal sclerosis. PLoS One. 2012; 7(12):e53382.Braun N, Alscher MD, Fritz P, Latus J, Edenhofer I, Reimold F, Alper SL, Kimmel M, Biegger D, Lindenmeyer M, Cohen CD, Wüthrich RP, Segerer S. PLoS One20127(12):e53382http://www.ncbi.nlm.nih.gov/pubmed/23271450Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger. Pflugers Arch. 2013 Jun; 465(6):839-51.Reimold FR, Stewart AK, Stolpe K, Heneghan JF, Shmukler BE, Alper SL. Pflugers Arch2013 Jun465(6):839-51http://www.ncbi.nlm.nih.gov/pubmed/23180570Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia. Am J Hematol. 2013 Jan; 88(1):66-72.Andolfo I, Alper SL, Delaunay J, Auriemma C, Russo R, Asci R, Esposito MR, Sharma AK, Shmukler BE, Brugnara C, De Franceschi L, Iolascon A. Am J Hematol2013 Jan88(1):66-72http://www.ncbi.nlm.nih.gov/pubmed/23071446Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone. PLoS Genet. 2012; 8(10):e1002971.Hailey DW, Roberts B, Owens KN, Stewart AK, Linbo T, Pujol R, Alper SL, Rubel EW, Raible DW. PLoS Genet20128(10):e1002971http://www.ncbi.nlm.nih.gov/pubmed/22802585Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. 2012 Nov 01; 590(21):5299-316.Huang J, Shan J, Kim D, Liao J, Evagelidis A, Alper SL, Hanrahan JW. J Physiol2012 Nov 01590(21):5299-316http://www.ncbi.nlm.nih.gov/pubmed/22406315Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25.Shmukler BE, Rivera A, Vandorpe DH, Alves J, Bonfanti U, Paltrinieri S, Alper SL. Blood Cells Mol Dis2012 Apr 1548(4):219-25http://www.ncbi.nlm.nih.gov/pubmed/22228178Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. J Mol Med (Berl). 2012 Jun; 90(6):707-18.Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ, Lu Y, Zheng L, Yan ZW, Fu GH. J Mol Med (Berl)2012 Jun90(6):707-18http://www.ncbi.nlm.nih.gov/pubmed/22118659Guanine nucleotides differentially modulate backbone dynamics of the STAS domain of the SulP/SLC26 transport protein Rv1739c of Mycobacterium tuberculosis. FEBS J. 2012 Feb; 279(3):420-36.Sharma AK, Ye L, Alper SL, Rigby AC. FEBS J2012 Feb279(3):420-36http://www.ncbi.nlm.nih.gov/pubmed/22129966The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol. 2012 Mar 01; 302(5):F614-24.Rozenfeld J, Tal O, Kladnitsky O, Adler L, Efrati E, Carrithers SL, Alper SL, Zelikovic I. Am J Physiol Renal Physiol2012 Mar 01302(5):F614-24http://www.ncbi.nlm.nih.gov/pubmed/22116369SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct. Cell Physiol Biochem. 2011; 28(3):545-52.Ito T, Choi BY, King KA, Zalewski CK, Muskett J, Chattaraj P, Shawker T, Reynolds JC, Butman JA, Brewer CC, Wangemann P, Alper SL, Griffith AJ. Cell Physiol Biochem201128(3):545-52http://www.ncbi.nlm.nih.gov/pubmed/22116353Transcriptional regulation of the pendrin gene. Cell Physiol Biochem. 2011; 28(3):385-96.Rozenfeld J, Efrati E, Adler L, Tal O, Carrithers SL, Alper SL, Zelikovic I. Cell Physiol Biochem201128(3):385-96http://www.ncbi.nlm.nih.gov/pubmed/22116355STAS domain structure and function. Cell Physiol Biochem. 2011; 28(3):407-22.Sharma AK, Rigby AC, Alper SL. Cell Physiol Biochem201128(3):407-22http://www.ncbi.nlm.nih.gov/pubmed/22116357Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50.Reimold FR, Heneghan JF, Stewart AK, Zelikovic I, Vandorpe DH, Shmukler BE, Alper SL. Cell Physiol Biochem201128(3):435-50http://www.ncbi.nlm.nih.gov/pubmed/22049207This, too, shall pass--like a kidney stone: a possible path to prophylaxis of nephrolithiasis? Focus on "Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells". Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C18-20.Heneghan JF, Alper SL. Am J Physiol Cell Physiol2012 Jan 01302(1):C18-20http://www.ncbi.nlm.nih.gov/pubmed/22058000Lack of association between catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a Turkish population. Genet Mol Res. 2011 Oct 31; 10(4):4126-32.Bulut H, Pehlivan M, Alper S, Tomatir AG, Onay H, Yüksel SE, Ozkinay F, Pehlivan S. Genet Mol Res2011 Oct 3110(4):4126-32http://www.ncbi.nlm.nih.gov/pubmed/21849667Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43.Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Am J Physiol Cell Physiol2011 Dec301(6):C1325-43http://www.ncbi.nlm.nih.gov/pubmed/21775626A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1. Mol Biol Cell. 2011 Sep; 22(18):3289-305.Ward HH, Brown-Glaberman U, Wang J, Morita Y, Alper SL, Bedrick EJ, Gattone VH, Deretic D, Wandinger-Ness A. Mol Biol Cell2011 Sep22(18):3289-305http://www.ncbi.nlm.nih.gov/pubmed/21593449SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C289-303.Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko S, Ishiguro H, Alper SL. Am J Physiol Cell Physiol2011 Aug301(2):C289-303http://www.ncbi.nlm.nih.gov/pubmed/21455273Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1. Biochem Cell Biol. 2011 Apr; 89(2):224-35.Stewart AK, Chebib FT, Akbar SW, Salas MJ, Sonik RA, Shmukler BE, Alper SL. Biochem Cell Biol2011 Apr89(2):224-35http://www.ncbi.nlm.nih.gov/pubmed/21358184Hereditary hearing loss with thyroid abnormalities. Adv Otorhinolaryngol. 2011; 70:43-49.Choi BY, Muskett J, King KA, Zalewski CK, Shawker T, Reynolds JC, Butman JA, Brewer CC, Stewart AK, Alper SL, Griffith AJ. Adv Otorhinolaryngol201170:43-49http://www.ncbi.nlm.nih.gov/pubmed/21209359Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46.Stewart AK, Kedar PS, Shmukler BE, Vandorpe DH, Hsu A, Glader B, Rivera A, Brugnara C, Alper SL. Am J Physiol Cell Physiol2011 May300(5):C1034-46http://www.ncbi.nlm.nih.gov/pubmed/21190940Solution structure of the guanine nucleotide-binding STAS domain of SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. J Biol Chem. 2011 Mar 11; 286(10):8534-8544.Sharma AK, Ye L, Baer CE, Shanmugasundaram K, Alber T, Alper SL, Rigby AC. J Biol Chem2011 Mar 11286(10):8534-8544http://www.ncbi.nlm.nih.gov/pubmed/21068358Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. Am J Physiol Cell Physiol. 2011 Feb; 300(2):C276-86.Alper SL, Stewart AK, Vandorpe DH, Clark JS, Horack RZ, Simpson JE, Walker NM, Clarke LL. Am J Physiol Cell Physiol2011 Feb300(2):C276-86http://www.ncbi.nlm.nih.gov/pubmed/21056571Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure. J Mol Cell Cardiol. 2011 Jan; 50(1):137-46.Al Moamen NJ, Prasad V, Bodi I, Miller ML, Neiman ML, Lasko VM, Alper SL, Wieczorek DF, Lorenz JN, Shull GE. J Mol Cell Cardiol2011 Jan50(1):137-46http://www.ncbi.nlm.nih.gov/pubmed/21170890Familial renal tubular acidosis. J Nephrol. 2010 Nov-Dec; 23 Suppl 16:S57-76.Alper SL. J Nephrol2010 Nov-Dec23 Suppl 16:S57-76http://www.ncbi.nlm.nih.gov/pubmed/21035933Tubular transport: core curriculum 2010. Am J Kidney Dis. 2010 Dec; 56(6):1202-17.Christov M, Alper SL. Am J Kidney Dis2010 Dec56(6):1202-17http://www.ncbi.nlm.nih.gov/pubmed/20799361Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. Am J Hematol. 2010 Oct; 85(10):824-8.Shmukler BE, Kedar PS, Warang P, Desai M, Madkaikar M, Ghosh K, Colah RB, Alper SL. Am J Hematol2010 Oct85(10):824-8http://www.ncbi.nlm.nih.gov/pubmed/20576809Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol. 2010 Sep; 21(9):1456-67.Wu F, Saleem MA, Kampik NB, Satchwell TJ, Williamson RC, Blattner SM, Ni L, Toth T, White G, Young MT, Parker MD, Alper SL, Wagner CA, Toye AM. J Am Soc Nephrol2010 Sep21(9):1456-67http://www.ncbi.nlm.nih.gov/pubmed/20219950Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1363-75.Heneghan JF, Akhavein A, Salas MJ, Shmukler BE, Karniski LP, Vandorpe DH, Alper SL. Am J Physiol Cell Physiol2010 Jun298(6):C1363-75http://www.ncbi.nlm.nih.gov/pubmed/20110461AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G493-503.Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE. Am J Physiol Gastrointest Liver Physiol2010 Apr298(4):G493-503http://www.ncbi.nlm.nih.gov/pubmed/20090940Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732.Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. PLoS One2010 Jan 155(1):e8732http://www.ncbi.nlm.nih.gov/pubmed/19932740Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus. Neuroscience. 2010 Feb 17; 165(4):1519-37.Belenky MA, Sollars PJ, Mount DB, Alper SL, Yarom Y, Pickard GE. Neuroscience2010 Feb 17165(4):1519-37http://www.ncbi.nlm.nih.gov/pubmed/19907019The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C283-97.Stewart AK, Vandorpe DH, Heneghan JF, Chebib F, Stolpe K, Akhavein A, Edelman EJ, Maksimova Y, Gallagher PG, Alper SL. Am J Physiol Cell Physiol2010 Feb298(2):C283-97http://www.ncbi.nlm.nih.gov/pubmed/19823673HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization. PLoS One. 2009 Oct 12; 4(10):e7417.Zhou C, Tiberi M, Liang B, Alper SL, Baltz JM. PLoS One2009 Oct 124(10):e7417http://www.ncbi.nlm.nih.gov/pubmed/19645628Efficient molecular genetic diagnosis of enlarged vestibular aqueducts in East Asians. Genet Test Mol Biomarkers. 2009 Oct; 13(5):679-87.Choi BY, Stewart AK, Nishimura KK, Cha WJ, Seong MW, Park SS, Kim SW, Chun YS, Chung JW, Park SN, Chang SO, Kim CS, Alper SL, Griffith AJ, Oh SH. Genet Test Mol Biomarkers2009 Oct13(5):679-87http://www.ncbi.nlm.nih.gov/pubmed/19723628Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem. 2009 Oct 23; 284(43):29470-9.Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M. J Biol Chem2009 Oct 23284(43):29470-9http://www.ncbi.nlm.nih.gov/pubmed/19509082Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss. Physiol Genomics. 2009 Aug 07; 38(3):281-90.Dai P, Stewart AK, Chebib F, Hsu A, Rozenfeld J, Huang D, Kang D, Lip V, Fang H, Shao H, Liu X, Yu F, Yuan H, Kenna M, Miller DT, Shen Y, Yang W, Zelikovic I, Platt OS, Han D, Alper SL, Wu BL. Physiol Genomics2009 Aug 0738(3):281-90http://www.ncbi.nlm.nih.gov/pubmed/19448077Molecular physiology and genetics of Na+-independent SLC4 anion exchangers. J Exp Biol. 2009 Jun; 212(Pt 11):1672-83.Alper SL. J Exp Biol2009 Jun212(Pt 11):1672-83http://www.ncbi.nlm.nih.gov/pubmed/19765723Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass. J Surg Res. 2009 Nov; 157(1):123-8.Feng J, Liu Y, Khabbaz KR, Sodha NR, Osipov RM, Hagberg R, Alper SL, Sellke FW. J Surg Res2009 Nov157(1):123-8http://www.ncbi.nlm.nih.gov/pubmed/19380103Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis. 2009 May-Jun; 42(3):233-40.Casula S, Zolotarev AS, Stuart-Tilley AK, Wilhelm S, Shmukler BE, Brugnara C, Alper SL. Blood Cells Mol Dis2009 May-Jun42(3):233-40http://www.ncbi.nlm.nih.gov/pubmed/19386787Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C263-77.Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE. Am J Physiol Cell Physiol2009 Aug297(2):C263-77http://www.ncbi.nlm.nih.gov/pubmed/19342507Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1307-17.Stewart AK, Yamamoto A, Nakakuki M, Kondo T, Alper SL, Ishiguro H. Am J Physiol Gastrointest Liver Physiol2009 Jun296(6):G1307-17http://www.ncbi.nlm.nih.gov/pubmed/19204907Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms? 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J Biol Chem2009 Mar 06284(10):6126-39http://www.ncbi.nlm.nih.gov/pubmed/19004773Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17955-60.Xu J, Song P, Miller ML, Borgese F, Barone S, Riederer B, Wang Z, Alper SL, Forte JG, Shull GE, Ehrenfeld J, Seidler U, Soleimani M. Proc Natl Acad Sci U S A2008 Nov 18105(46):17955-60http://www.ncbi.nlm.nih.gov/pubmed/18824768Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest. Circulation. 2008 Sep 30; 118(14 Suppl):S46-51.Feng J, Liu Y, Clements RT, Sodha NR, Khabbaz KR, Senthilnathan V, Nishimura KK, Alper SL, Sellke FW. Circulation2008 Sep 30118(14 Suppl):S46-51http://www.ncbi.nlm.nih.gov/pubmed/18756294Let's look at cysts from both sides now. Kidney Int. 2008 Sep; 74(6):699-702.Alper SL. 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Am J Physiol Cell Physiol2008 Aug295(2):C302-12http://www.ncbi.nlm.nih.gov/pubmed/18329299Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):22-34.Alper SL, Vandorpe DH, Peters LL, Brugnara C. Blood Cells Mol Dis2008 Jul-Aug41(1):22-34http://www.ncbi.nlm.nih.gov/pubmed/18192337Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity. Exp Physiol. 2008 Apr; 93(4):458-67.Kurschat CE, Shmukler BE, Jiang L, Hevi S, Kim EH, Stewart AK, Alper SL. Exp Physiol2008 Apr93(4):458-67http://www.ncbi.nlm.nih.gov/pubmed/18174209Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol. 2008 Mar 01; 586(5):1291-306.Clark JS, Vandorpe DH, Chernova MN, Heneghan JF, Stewart AK, Alper SL. J Physiol2008 Mar 01586(5):1291-306http://www.ncbi.nlm.nih.gov/pubmed/18255326Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Comp Biochem Physiol A Mol Integr Physiol2008 Mar149(3):255-66http://www.ncbi.nlm.nih.gov/pubmed/18046018Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R1081-91.Shmukler BE, Clark JS, Hsu A, Vandorpe DH, Stewart AK, Kurschat CE, Choe SK, Zhou Y, Amigo J, Paw BH, Alper SL. Am J Physiol Regul Integr Comp Physiol2008 Mar294(3):R1081-91http://www.ncbi.nlm.nih.gov/pubmed/18024369K-CL co-transport plays an important role in normal and beta thalassemic erythropoiesis. Haematologica. 2007 Oct; 92(10):1319-26.De Franceschi L, Ronzoni L, Cappellini MD, Cimmino F, Siciliano A, Alper SL, Servedio V, Pozzobon C, Iolascon A. Haematologica2007 Oct92(10):1319-26http://www.ncbi.nlm.nih.gov/pubmed/17890222Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem. 2007 Nov 30; 282(48):35125-32.Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE. J Biol Chem2007 Nov 30282(48):35125-32http://www.ncbi.nlm.nih.gov/pubmed/17690150Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007 Oct 01; 584(Pt 1):59-73.Stewart AK, Kurschat CE, Vaughan-Jones RD, Shmukler BE, Alper SL. J Physiol2007 Oct 01584(Pt 1):59-73http://www.ncbi.nlm.nih.gov/pubmed/17652362Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse. 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Am J Physiol Regul Integr Comp Physiol2005 Dec289(6):R1644-58http://www.ncbi.nlm.nih.gov/pubmed/16150231Erythromelanosis follicularis faciei et colli: report of involvement in two female patients. Dermatol Online J. 2005 Aug 01; 11(2):23.Ertam I, Unal I, Alper S. Dermatol Online J2005 Aug 0111(2):23http://www.ncbi.nlm.nih.gov/pubmed/16014040Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes. Kidney Int. 2005 Aug; 68(2):632-41.Chernova MN, Vandorpe DH, Clark JS, Alper SL. Kidney Int2005 Aug68(2):632-41http://www.ncbi.nlm.nih.gov/pubmed/15914778Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.Shmukler BE, Kurschat CE, Ackermann GE, Jiang L, Zhou Y, Barut B, Stuart-Tilley AK, Zhao J, Zon LI, Drummond IA, Vandorpe DH, Paw BH, Alper SL. Am J Physiol Renal Physiol2005 Oct289(4):F835-49http://www.ncbi.nlm.nih.gov/pubmed/15814591The abts and sulp families of anion transporters from Caenorhabditis elegans. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C341-51.Sherman T, Chernova MN, Clark JS, Jiang L, Alper SL, Nehrke K. Am J Physiol Cell Physiol2005 Aug289(2):C341-51http://www.ncbi.nlm.nih.gov/pubmed/15579501Regulation of the Cl-/HCO3- exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance. J Am Soc Nephrol. 2004 Dec; 15(12):2988-97.Quentin F, Eladari D, Frische S, Cambillau M, Nielsen S, Alper SL, Paillard M, Chambrey R. J Am Soc Nephrol2004 Dec15(12):2988-97http://www.ncbi.nlm.nih.gov/pubmed/15533301Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Biochim Biophys Acta. 2004 Nov 17; 1667(1):7-14.Davies SL, Roussa E, Le Rouzic P, Thévenod F, Alper SL, Best L, Brown PD. Biochim Biophys Acta2004 Nov 171667(1):7-14http://www.ncbi.nlm.nih.gov/pubmed/15548529Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 04; 280(9):8564-80.Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL. J Biol Chem2005 Mar 04280(9):8564-80http://www.ncbi.nlm.nih.gov/pubmed/15452108Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain. J Biol Chem. 2004 Dec 10; 279(50):52664-76.Stewart AK, Kerr N, Chernova MN, Alper SL, Vaughan-Jones RD. J Biol Chem2004 Dec 10279(50):52664-76http://www.ncbi.nlm.nih.gov/pubmed/15347667Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. J Biol Chem2004 Nov 12279(46):47681-7http://www.ncbi.nlm.nih.gov/pubmed/15262997Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. J Biol Chem. 2004 Sep 17; 279(38):40017-25.Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY. J Biol Chem2004 Sep 17279(38):40017-25http://www.ncbi.nlm.nih.gov/pubmed/15123620Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. J Biol Chem. 2004 Jul 16; 279(29):30531-9.Gawenis LR, Ledoussal C, Judd LM, Prasad V, Alper SL, Stuart-Tilley A, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE. J Biol Chem2004 Jul 16279(29):30531-9http://www.ncbi.nlm.nih.gov/pubmed/15067510Defects in processing and trafficking of the AE1 Cl-/HCO3- exchanger associated with inherited distal renal tubular acidosis. Clin Exp Nephrol. 2004 Mar; 8(1):1-11.Shayakul C, Alper SL. 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Am J Physiol Cell Physiol. 2004 May; 286(5):C998-C1008.Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI. Am J Physiol Cell Physiol2004 May286(5):C998-C1008http://www.ncbi.nlm.nih.gov/pubmed/14703602Gastrointestinal side effect profile due to the use of alendronate in the treatment of osteoporosis. Yonsei Med J. 2003 Dec 30; 44(6):961-7.Aki S, Eskiyurt N, Akarirmak U, Tüzün F, Eryavuz M, Alper S, Arpacioglu O, Atalay F, Kavuncu V, Kokino S, Kuru O, Nas K, Ozerbil O, Savas G, Sendur OF, Soy D, Akyüz G. Yonsei Med J2003 Dec 3044(6):961-7http://www.ncbi.nlm.nih.gov/pubmed/12958022Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G312-20.Nguyen HV, Stuart-Tilley A, Alper SL, Melvin JE. Am J Physiol Gastrointest Liver Physiol2004 Feb286(2):G312-20http://www.ncbi.nlm.nih.gov/pubmed/12933803Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. J Biol Chem. 2003 Nov 07; 278(45):44949-58.Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. J Biol Chem2003 Nov 07278(45):44949-58http://www.ncbi.nlm.nih.gov/pubmed/12902337KCl cotransport is an important modulator of human cervical cancer growth and invasion. J Biol Chem. 2003 Oct 10; 278(41):39941-50.Shen MR, Chou CY, Hsu KF, Hsu YM, Chiu WT, Tang MJ, Alper SL, Ellory JC. J Biol Chem2003 Oct 10278(41):39941-50http://www.ncbi.nlm.nih.gov/pubmed/12818688Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors. Farmaco. 2003 Jul; 58(7):497-507.Alper S, Temiz Arpaci O, Sener Aki E, Yalçin I. 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Int J Dermatol2002 Oct41(10):687-8http://www.ncbi.nlm.nih.gov/pubmed/12091304The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development. 2002 Jul; 129(14):3335-48.Alper S, Kenyon C. Development2002 Jul129(14):3335-48http://www.ncbi.nlm.nih.gov/pubmed/11981080Successful treatment of post-transplant Kaposi's sarcoma by reduction of immunosuppression. Nephrol Dial Transplant. 2002 May; 17(5):892-6.Duman S, Töz H, Asçi G, Alper S, Ozkahya M, Unal I, Celik A, Ok E, Basçi A. Nephrol Dial Transplant2002 May17(5):892-6http://www.ncbi.nlm.nih.gov/pubmed/12195579Topical photodynamic therapy for intraepidermal epithelioma. J Eur Acad Dermatol Venereol. 2002 May; 16(3):292-4.Ceylan C, Erboz S, Ozdemir F, Alper S. J Eur Acad Dermatol Venereol2002 May16(3):292-4http://www.ncbi.nlm.nih.gov/pubmed/11976906Immunolocalization of potassium-chloride cotransporter polypeptides in rat exocrine glands. Histochem Cell Biol. 2002 Apr; 117(4):335-44.Roussa E, Shmukler BE, Wilhelm S, Casula S, Stuart-Tilley AK, Thévenod F, Alper SL. Histochem Cell Biol2002 Apr117(4):335-44http://www.ncbi.nlm.nih.gov/pubmed/12027221The AE gene family of Cl/HCO3- exchangers. J Nephrol. 2002 Mar-Apr; 15 Suppl 5:S41-53.Alper SL, Darman RB, Chernova MN, Dahl NK. J Nephrol2002 Mar-Apr15 Suppl 5:S41-53http://www.ncbi.nlm.nih.gov/pubmed/11875186Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics. 2002 Feb 28; 8(2):87-98.Vandorpe DH, Wilhelm S, Jiang L, Ibraghimov-Beskrovnaya O, Chernova MN, Stuart-Tilley AK, Alper SL. Physiol Genomics2002 Feb 288(2):87-98http://www.ncbi.nlm.nih.gov/pubmed/11826292Genetic diseases of acid-base transporters. Annu Rev Physiol. 2002; 64:899-923.Alper SL. 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Am J Physiol Cell Physiol2001 Dec281(6):C1978-90http://www.ncbi.nlm.nih.gov/pubmed/11546673Regulation of AE2 anion exchanger by intracellular pH: critical regions of the NH(2)-terminal cytoplasmic domain. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1344-54.Stewart AK, Chernova MN, Kunes YZ, Alper SL. Am J Physiol Cell Physiol2001 Oct281(4):C1344-54http://www.ncbi.nlm.nih.gov/pubmed/11546677K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1385-95.De Franceschi L, Villa-Moruzzi E, Fumagalli L, Brugnara C, Turrini F, Motta R, Veghini E, Corato C, Alper SL, Berton G. Am J Physiol Cell Physiol2001 Oct281(4):C1385-95http://www.ncbi.nlm.nih.gov/pubmed/11572991Drought- and salt-tolerant plants result from overexpression of the AVP1 H+-pump. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11444-9.Gaxiola RA, Li J, Undurraga S, Dang LM, Allen GJ, Alper SL, Fink GR. Proc Natl Acad Sci U S A2001 Sep 2598(20):11444-9http://www.ncbi.nlm.nih.gov/pubmed/11551954A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 09; 276(45):41870-8.Casula S, Shmukler BE, Wilhelm S, Stuart-Tilley AK, Su W, Chernova MN, Brugnara C, Alper SL. J Biol Chem2001 Nov 09276(45):41870-8http://www.ncbi.nlm.nih.gov/pubmed/11483713Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. J Physiol. 2001 Aug 01; 534(Pt 3):837-48.Rossmann H, Bachmann O, Wang Z, Shull GE, Obermaier B, Stuart-Tilley A, Alper SL, Seidler U. J Physiol2001 Aug 01534(Pt 3):837-48http://www.ncbi.nlm.nih.gov/pubmed/11875255Regulation of Na+-independent Cl-/HCO3- exchangers by pH. JOP. 2001 Jul; 2(4 Suppl):171-5.Alper SL, Chernova MN, Stewart AK. JOP2001 Jul2(4 Suppl):171-5http://www.ncbi.nlm.nih.gov/pubmed/11287327Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. Am J Physiol Cell Physiol. 2001 May; 280(5):C1140-50.Jiang L, Jha V, Dhanabal M, Sukhatme VP, Alper SL. Am J Physiol Cell Physiol2001 May280(5):C1140-50http://www.ncbi.nlm.nih.gov/pubmed/11311160REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Development. 2001 May; 128(10):1793-804.Alper S, Kenyon C. Development2001 May128(10):1793-804http://www.ncbi.nlm.nih.gov/pubmed/12819792Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia. Drug News Perspect. 2001 May; 14(4):208-20.Brugnara C, De Franceschi L, Bennekou P, Alper SL, Christophersen P. Drug News Perspect2001 May14(4):208-20http://www.ncbi.nlm.nih.gov/pubmed/11285365VHL tumor suppressor regulates Cl-/HCO3- exchange and Na+/H+ exchange activities in renal carcinoma cells. Physiol Genomics. 2001 Apr 02; 5(3):119-28.Karumanchi SA, Jiang L, Knebelmann B, Stuart-Tilley AK, Alper SL, Sukhatme VP. Physiol Genomics2001 Apr 025(3):119-28http://www.ncbi.nlm.nih.gov/pubmed/11259449Immunolocalization of anion exchanger AE2, Na(+)/H(+) exchangers NHE1 and NHE4, and vacuolar type H(+)-ATPase in rat pancreas. J Histochem Cytochem. 2001 Apr; 49(4):463-74.Roussa E, Alper SL, Thévenod F. J Histochem Cytochem2001 Apr49(4):463-74http://www.ncbi.nlm.nih.gov/pubmed/11267657Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001 Mar 19; 1518(1-2):36-46.Shmukler BE, Bond CT, Wilhelm S, Bruening-Wright A, Maylie J, Adelman JP, Alper SL. Biochim Biophys Acta2001 Mar 191518(1-2):36-46http://www.ncbi.nlm.nih.gov/pubmed/11228191Sporadic cases of Liddle's syndrome: clues to essential hypertension? Am J Kidney Dis. 2001 Mar; 37(3):632-5.Alper SL. Am J Kidney Dis2001 Mar37(3):632-5http://www.ncbi.nlm.nih.gov/pubmed/11179033AE anion exchangers in atrial tumor cells. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H937-45.Papageorgiou P, Shmukler BE, Stuart-Tilley AK, Jiang L, Alper SL. Am J Physiol Heart Circ Physiol2001 Mar280(3):H937-45http://www.ncbi.nlm.nih.gov/pubmed/11171302Physiological and molecular characterization of urea transport by the gills of the Lake Magadi tilapia (Alcolapia grahami). J Exp Biol. 2001 Feb; 204(Pt 3):509-20.Walsh PJ, Grosell M, Goss GG, Bergman HL, Bergman AN, Wilson P, Laurent P, Alper SL, Smith CP, Kamunde C, Wood CM. J Exp Biol2001 Feb204(Pt 3):509-20http://www.ncbi.nlm.nih.gov/pubmed/11052990Regulation of DRA and AE1 in rat colon by dietary Na depletion. Am J Physiol Gastrointest Liver Physiol. 2000 Nov; 279(5):G931-42.Rajendran VM, Black J, Ardito TA, Sangan P, Alper SL, Schweinfest C, Kashgarian M, Binder HJ. Am J Physiol Gastrointest Liver Physiol2000 Nov279(5):G931-42http://www.ncbi.nlm.nih.gov/pubmed/11044446The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel. J Biol Chem. 2001 Feb 09; 276(6):4093-101.Vandorpe DH, Chernova MN, Jiang L, Sellin LK, Wilhelm S, Stuart-Tilley AK, Walz G, Alper SL. J Biol Chem2001 Feb 09276(6):4093-101http://www.ncbi.nlm.nih.gov/pubmed/11003582Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1016-23.Loffing J, Moyer BD, Reynolds D, Shmukler BE, Alper SL, Stanton BA. Am J Physiol Cell Physiol2000 Oct279(4):C1016-23http://www.ncbi.nlm.nih.gov/pubmed/10990375Inherited renal tubular acidosis. Curr Opin Nephrol Hypertens. 2000 Sep; 9(5):541-6.Shayakul C, Alper SL. 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J Gen Physiol. 2000 May; 115(5):599-608.Klein M, Seeger P, Schuricht B, Alper SL, Schwab A. J Gen Physiol2000 May115(5):599-608http://www.ncbi.nlm.nih.gov/pubmed/11032077Generalized Trichophyton rubrum infection in a subject with pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2000 May; 14(3):228-30.Ozdemir F, Erboz S, Unal I, Alper S, Aytimur D, Ozol A, Aytimur M. J Eur Acad Dermatol Venereol2000 May14(3):228-30http://www.ncbi.nlm.nih.gov/pubmed/10804703Effects of using a photographic cueing package during routine school transitions with a child who has autism. Ment Retard. 2000 Apr; 38(2):131-7.Schmit J, Alper S, Raschke D, Ryndak D. Ment Retard2000 Apr38(2):131-7http://www.ncbi.nlm.nih.gov/pubmed/11193604Three 5'-variant mRNAs of anion exchanger AE2 in stomach and intestine of mouse, rabbit, and rat. Ann N Y Acad Sci. 2000; 915:81-91.Rossmann H, Alper SL, Nader M, Wang Z, Gregor M, Seidler U. Ann N Y Acad Sci2000915:81-91http://www.ncbi.nlm.nih.gov/pubmed/11328653Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger. DNA Seq. 2000; 11(5):447-50.Shmukler BE, Wilhelm S, Alper SL. DNA Seq200011(5):447-50http://www.ncbi.nlm.nih.gov/pubmed/10565809Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits. J Pharmacol Exp Ther. 1999 Dec; 291(3):943-52.Mourre C, Chernova MN, Martin-Eauclaire MF, Bessone R, Jacquet G, Gola M, Alper SL, Crest M. J Pharmacol Exp Ther1999 Dec291(3):943-52http://www.ncbi.nlm.nih.gov/pubmed/10591386Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999 Dec 01; 282(21):2035-42.Malek AM, Alper SL, Izumo S. JAMA1999 Dec 01282(21):2035-42http://www.ncbi.nlm.nih.gov/pubmed/10600827Immunolocalization of anion exchanger AE2 and Na(+)-HCO(-)(3) cotransporter in rat parotid and submandibular glands. Am J Physiol. 1999 12; 277(6):G1288-96.Roussa E, Romero MF, Schmitt BM, Boron WF, Alper SL, Thévenod F. Am J Physiol1999 12277(6):G1288-96http://www.ncbi.nlm.nih.gov/pubmed/10564083Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol. 1999 11; 277(5):C899-912.Su W, Shmukler BE, Chernova MN, Stuart-Tilley AK, de Franceschi L, Brugnara C, Alper SL. Am J Physiol1999 11277(5):C899-912http://www.ncbi.nlm.nih.gov/pubmed/10491632Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999 Oct; 61(4):973-80.Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S. Biol Reprod1999 Oct61(4):973-80http://www.ncbi.nlm.nih.gov/pubmed/10430991Gene therapy of inherited renal tubular disease. Am J Kidney Dis. 1999 Aug; 34(2):374-9.Shayakul C, Breton S, Brown D, Alper SL. Am J Kidney Dis1999 Aug34(2):374-9http://www.ncbi.nlm.nih.gov/pubmed/10444446Expression of AE2 anion exchanger in mouse intestine. Am J Physiol. 1999 08; 277(2):G321-32.Alper SL, Rossmann H, Wilhelm S, Stuart-Tilley AK, Shmukler BE, Seidler U. Am J Physiol1999 08277(2):G321-32http://www.ncbi.nlm.nih.gov/pubmed/10449079Modulation by pathophysiological stimuli of the shear stress-induced up-regulation of endothelial nitric oxide synthase expression in endothelial cells. Neurosurgery. 1999 Aug; 45(2):334-44; discussion 344-5.Malek AM, Izumo S, Alper SL. Neurosurgery1999 Aug45(2):334-44; discussion 344-5http://www.ncbi.nlm.nih.gov/pubmed/10387099AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. Biochemistry. 1999 Jun 29; 38(26):8521-31.Zolotarev AS, Shmukler BE, Alper SL. Biochemistry1999 Jun 2938(26):8521-31http://www.ncbi.nlm.nih.gov/pubmed/9990049The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1480-5.Gaxiola RA, Rao R, Sherman A, Grisafi P, Alper SL, Fink GR. Proc Natl Acad Sci U S A1999 Feb 1696(4):1480-5http://www.ncbi.nlm.nih.gov/pubmed/10093051Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels. J Mol Cell Cardiol. 1999 Feb; 31(2):387-99.Malek AM, Zhang J, Jiang J, Alper SL, Izumo S. J Mol Cell Cardiol1999 Feb31(2):387-99http://www.ncbi.nlm.nih.gov/pubmed/9920763Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. Biochem Biophys Res Commun. 1999 Jan 08; 254(1):231-42.Malek AM, Jiang L, Lee I, Sessa WC, Izumo S, Alper SL. Biochem Biophys Res Commun1999 Jan 08254(1):231-42http://www.ncbi.nlm.nih.gov/pubmed/9869622The potassium channel and how it works. Gastroenterology. 1999 Jan; 116(1):216-7.Lencer WI, Alper SL. Gastroenterology1999 Jan116(1):216-7http://www.ncbi.nlm.nih.gov/pubmed/11811173Periodontal lesions in lipoid proteinosis. Periodontal Clin Investig. 1999; 21(1):21-3.Iigenli T, Varol A, Alper S, Kandemir S. Periodontal Clin Investig199921(1):21-3http://www.ncbi.nlm.nih.gov/pubmed/9854053Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A. J Clin Invest. 1998 Dec 15; 102(12):2173-9.Tanphaichitr VS, Sumboonnanonda A, Ideguchi H, Shayakul C, Brugnara C, Takao M, Veerakul G, Alper SL. J Clin Invest1998 Dec 15102(12):2173-9http://www.ncbi.nlm.nih.gov/pubmed/9836777Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke. 1998 Dec; 29(12):2631-40.Malek AM, Goss GG, Jiang L, Izumo S, Alper SL. Stroke1998 Dec29(12):2631-40http://www.ncbi.nlm.nih.gov/pubmed/9804866The guinea pig cochlear AE2 anion exchanger: cDNA cloning and in situ localization within the cochlea. Biochim Biophys Acta. 1998 Nov 11; 1414(1-2):1-15.Mhatre AN, Charachon G, Alper SL, Lalwani AK. Biochim Biophys Acta1998 Nov 111414(1-2):1-15http://www.ncbi.nlm.nih.gov/pubmed/9729505Functional and molecular characterization of luminal and basolateral Cl-/HCO-3 exchangers of rat thick limbs. Am J Physiol. 1998 09; 275(3):F334-42.Eladari D, Blanchard A, Leviel F, Paillard M, Stuart-Tilley AK, Alper SL, Podevin RA. Am J Physiol1998 09275(3):F334-42http://www.ncbi.nlm.nih.gov/pubmed/9705284cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.Vandorpe DH, Shmukler BE, Jiang L, Lim B, Maylie J, Adelman JP, de Franceschi L, Cappellini MD, Brugnara C, Alper SL. J Biol Chem1998 Aug 21273(34):21542-53http://www.ncbi.nlm.nih.gov/pubmed/9688603Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells. Am J Physiol. 1998 08; 275(2):C484-95.Merlin D, Jiang L, Strohmeier GR, Nusrat A, Alper SL, Lencer WI, Madara JL. Am J Physiol1998 08275(2):C484-95http://www.ncbi.nlm.nih.gov/pubmed/9698524Clotrimazole is a potent vasodilator of the rat coronary microcirculation. J Surg Res. 1998 Jun; 77(1):6-10.Tofukuji M, Metais C, Wang SY, Alper SL, Sellke FW. J Surg Res1998 Jun77(1):6-10http://www.ncbi.nlm.nih.gov/pubmed/9621277Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. J Am Soc Nephrol. 1998 Jun; 9(6):946-59.Stuart-Tilley AK, Shmukler BE, Brown D, Alper SL. J Am Soc Nephrol1998 Jun9(6):946-59http://www.ncbi.nlm.nih.gov/pubmed/9719650Interdependence and Controversy in Group Decision Making: Antecedents to Effective Self-Managing Teams. Organ Behav Hum Decis Process. 1998 Apr; 74(1):33-52.Alper S, Tjosvold D, Law KS. Organ Behav Hum Decis Process1998 Apr74(1):33-52http://www.ncbi.nlm.nih.gov/pubmed/9497368Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger. J Biol Chem. 1998 Mar 13; 273(11):6380-8.Jarolim P, Shayakul C, Prabakaran D, Jiang L, Stuart-Tilley A, Rubin HL, Simova S, Zavadil J, Herrin JT, Brouillette J, Somers MJ, Seemanova E, Brugnara C, Guay-Woodford LM, Alper SL. J Biol Chem1998 Mar 13273(11):6380-8http://www.ncbi.nlm.nih.gov/pubmed/10353714Differential inhibition of AE1 and AE2 anion exchangers by oxonol dyes and by novel polyaminosterol analogs of the shark antibiotic squalamine. Biochem Cell Biol. 1998; 76(5):799-806.Alper SL, Chernova MN, Williams J, Zasloff M, Law FY, Knauf PA. Biochem Cell Biol199876(5):799-806http://www.ncbi.nlm.nih.gov/pubmed/9399958The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J Clin Invest. 1997 Dec 15; 100(12):3111-20.Rufo PA, Merlin D, Riegler M, Ferguson-Maltzman MH, Dickinson BL, Brugnara C, Alper SL, Lencer WI. J Clin Invest1997 Dec 15100(12):3111-20http://www.ncbi.nlm.nih.gov/pubmed/9435694AE anion exchanger mRNA and protein expression in vascular smooth muscle cells, aorta, and renal microvessels. Am J Physiol. 1997 12; 273(6):F1039-47.Brosius FC, Pisoni RL, Cao X, Deshmukh G, Yannoukakos D, Stuart-Tilley AK, Haller C, Alper SL. Am J Physiol1997 12273(6):F1039-47http://www.ncbi.nlm.nih.gov/pubmed/9447915Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear. Hear Res. 1997 Dec; 114(1-2):21-34.Stankovic KM, Brown D, Alper SL, Adams JC. Hear Res1997 Dec114(1-2):21-34http://www.ncbi.nlm.nih.gov/pubmed/9374665Regulation of endothelin-1 gene expression by cell shape and the microfilament network in vascular endothelium. Am J Physiol. 1997 11; 273(5):C1764-74.Malek AM, Lee IW, Alper SL, Izumo S. Am J Physiol1997 11273(5):C1764-74http://www.ncbi.nlm.nih.gov/pubmed/9370249Functional consequences of mutations in the transmembrane domain and the carboxy-terminus of the murine AE1 anion exchanger. Biochim Biophys Acta. 1997 Oct 02; 1329(1):111-23.Chernova MN, Humphreys BD, Robinson DH, Stuart-Tilley AK, Garcia AM, Brosius FC, Alper SL. Biochim Biophys Acta1997 Oct 021329(1):111-23http://www.ncbi.nlm.nih.gov/pubmed/9312186Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1997 Oct 01; 100(7):1847-52.De Franceschi L, Bachir D, Galacteros F, Tchernia G, Cynober T, Alper S, Platt O, Beuzard Y, Brugnara C. J Clin Invest1997 Oct 01100(7):1847-52http://www.ncbi.nlm.nih.gov/pubmed/9362338Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol. 1997 10; 273(4):F601-14.Alper SL, Stuart-Tilley AK, Biemesderfer D, Shmukler BE, Brown D. Am J Physiol1997 10273(4):F601-14http://www.ncbi.nlm.nih.gov/pubmed/9281344Routes of Cl- transport across the trophectoderm of the mouse blastocyst. Dev Biol. 1997 Sep 01; 189(1):148-60.Zhao Y, Doroshenko PA, Alper SL, Baltz JM. Dev Biol1997 Sep 01189(1):148-60http://www.ncbi.nlm.nih.gov/pubmed/9277440Protection of perfused lung from oxidant injury by inhibitors of anion exchange. Am J Physiol. 1997 Aug; 273(2 Pt 1):L296-304.Nozik-Grayck E, Piantadosi CA, van Adelsberg J, Alper SL, Huang YC. Am J Physiol1997 Aug273(2 Pt 1):L296-304http://www.ncbi.nlm.nih.gov/pubmed/9252441Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole. Am J Physiol. 1997 Jul; 273(1 Pt 1):C45-56.Rittenhouse AR, Parker C, Brugnara C, Morgan KG, Alper SL. Am J Physiol1997 Jul273(1 Pt 1):C45-56http://www.ncbi.nlm.nih.gov/pubmed/9211355Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. Kidney Int. 1997 Jul; 52(1):130-9.Joannidis M, Cantley LG, Spokes K, Stuart-Tilley AK, Alper SL, Epstein FH. Kidney Int1997 Jul52(1):130-9http://www.ncbi.nlm.nih.gov/pubmed/9227424Regulation of vascular smooth muscle cell proliferation by plasma membrane Ca(2+)-ATPase. Am J Physiol. 1997 Jun; 272(6 Pt 1):C1947-59.Husain M, Jiang L, See V, Bein K, Simons M, Alper SL, Rosenberg RD. Am J Physiol1997 Jun272(6 Pt 1):C1947-59http://www.ncbi.nlm.nih.gov/pubmed/9187767Quantitative densitometric analysis using a commercially available handheld CCD digital camera. Biotechniques. 1997 Jun; 22(6):1150-3.Malek AM, Izumo S, Alper SL. Biotechniques1997 Jun22(6):1150-3http://www.ncbi.nlm.nih.gov/pubmed/9151659The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J Membr Biol. 1997 May 15; 157(2):177-91.Rittenhouse AR, Vandorpe DH, Brugnara C, Alper SL. J Membr Biol1997 May 15157(2):177-91http://www.ncbi.nlm.nih.gov/pubmed/9176168Autosomal dominant polycystic kidney disease decreases anion exchanger activity. Am J Physiol. 1997 May; 272(5 Pt 1):C1748-56.Perrone RD, Grubman SA, Murray SL, Lee DW, Alper SL, Jefferson DM. Am J Physiol1997 May272(5 Pt 1):C1748-56http://www.ncbi.nlm.nih.gov/pubmed/9130442c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells. Circ Res. 1997 May; 80(5):617-26.Husain M, Bein K, Jiang L, Alper SL, Simons M, Rosenberg RD. Circ Res1997 May80(5):617-26http://www.ncbi.nlm.nih.gov/pubmed/9142848NH4Cl activates AE2 anion exchanger in Xenopus oocytes at acidic pHi. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1232-40.Humphreys BD, Chernova MN, Jiang L, Zhang Y, Alper SL. Am J Physiol1997 Apr272(4 Pt 1):C1232-40http://www.ncbi.nlm.nih.gov/pubmed/9130171Is resting state HCO3- secretion in frog gastric fundus mucosa mediated by apical Cl(-)-HCO3- exchange? J Physiol. 1997 Mar 15; 499 ( Pt 3):763-71.Caroppo R, Debellis L, Valenti G, Alper S, Frömter E, Curci S. J Physiol1997 Mar 15499 ( Pt 3):763-71http://www.ncbi.nlm.nih.gov/pubmed/9089441Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q. J Gen Physiol. 1997 Mar; 109(3):345-60.Chernova MN, Jiang L, Crest M, Hand M, Vandorpe DH, Strange K, Alper SL. J Gen Physiol1997 Mar109(3):345-60http://www.ncbi.nlm.nih.gov/pubmed/8995726Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37.Sabolic I, Brown D, Gluck SL, Alper SL. Kidney Int1997 Jan51(1):125-37http://www.ncbi.nlm.nih.gov/pubmed/9038825Secondary regulatory volume increase conferred on Xenopus oocytes by expression of AE2 anion exchanger. Am J Physiol. 1997 Jan; 272(1 Pt 1):C191-202.Jiang L, Chernova MN, Alper SL. Am J Physiol1997 Jan272(1 Pt 1):C191-202http://www.ncbi.nlm.nih.gov/pubmed/9038842Reinterpretation of the RACTK1 K+ channel. Am J Physiol. 1997 Jan; 272(1 Pt 1):C350-4.Shmukler B, Sun T, Brugnara C, Alper SL. Am J Physiol1997 Jan272(1 Pt 1):C350-4http://www.ncbi.nlm.nih.gov/pubmed/9064641Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch. 1997 Jan; 433(3):260-8.He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ. Pflugers Arch1997 Jan433(3):260-8http://www.ncbi.nlm.nih.gov/pubmed/8903326The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest. 1996 Nov 01; 98(9):2066-75.Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI. J Clin Invest1996 Nov 0198(9):2066-75http://www.ncbi.nlm.nih.gov/pubmed/8808627Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Cell1996 Sep 2086(6):917-27http://www.ncbi.nlm.nih.gov/pubmed/8756692Proteolytic cleavage sites of native AE2 anion exchanger in gastric mucosal membranes. Biochemistry. 1996 Aug 13; 35(32):10367-76.Zolotarev AS, Chernova MN, Yannoukakos D, Alper SL. Biochemistry1996 Aug 1335(32):10367-76http://www.ncbi.nlm.nih.gov/pubmed/8770047HCO3(-)-dependent conformational change in gastric parietal cell AE2, a glycoprotein naturally lacking sialic acid. Am J Physiol. 1996 Aug; 271(2 Pt 1):G311-21.Zolotarev AS, Townsend RR, Stuart-Tilley A, Alper SL. Am J Physiol1996 Aug271(2 Pt 1):G311-21http://www.ncbi.nlm.nih.gov/pubmed/8764397SpoIIAA governs the release of the cell-type specific transcription factor sigma F from its anti-sigma factor SpoIIAB. J Mol Biol. 1996 Jul 12; 260(2):147-64.Duncan L, Alper S, Losick R. J Mol Biol1996 Jul 12260(2):147-64http://www.ncbi.nlm.nih.gov/pubmed/8764398Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis. J Mol Biol. 1996 Jul 12; 260(2):165-77.Alper S, Dufour A, Garsin DA, Duncan L, Losick R. J Mol Biol1996 Jul 12260(2):165-77http://www.ncbi.nlm.nih.gov/pubmed/9078383Subcellular localization of proteins governing the proteolytic activation of a developmental transcription factor in Bacillus subtilis. Genes Cells. 1996 Jun; 1(6):529-42.Resnekov O, Alper S, Losick R. Genes Cells1996 Jun1(6):529-42http://www.ncbi.nlm.nih.gov/pubmed/8661729Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Mamm Genome. 1996 May; 7(5):380-2.Simon JS, Deshmukh G, Couch FJ, Merajver SD, Weber BL, Van Vooren P, Tissil F, Szpirer J, Szpirer C, Alper SL, Jacob HJ, Brosius FC. Mamm Genome1996 May7(5):380-2http://www.ncbi.nlm.nih.gov/pubmed/8622920SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3238-42.Arigoni F, Duncan L, Alper S, Losick R, Stragier P. Proc Natl Acad Sci U S A1996 Apr 1693(8):3238-42http://www.ncbi.nlm.nih.gov/pubmed/9072183Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS). Histochem Cell Biol. 1996 Apr; 105(4):261-7.Brown D, Lydon J, McLaughlin M, Stuart-Tilley A, Tyszkowski R, Alper S. Histochem Cell Biol1996 Apr105(4):261-7http://www.ncbi.nlm.nih.gov/pubmed/8621440The cytoplasmic and transmembrane domains of AE2 both contribute to regulation of anion exchange by pH. J Biol Chem. 1996 Mar 08; 271(10):5741-9.Zhang Y, Chernova MN, Stuart-Tilley AK, Jiang L, Alper SL. J Biol Chem1996 Mar 08271(10):5741-9http://www.ncbi.nlm.nih.gov/pubmed/8636434Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 01; 97(5):1227-34.Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS. J Clin Invest1996 Mar 0197(5):1227-34http://www.ncbi.nlm.nih.gov/pubmed/8638668Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport. Am J Physiol. 1996 Mar; 270(3 Pt 1):C866-77.Armsby CC, Stuart-Tilley AK, Alper SL, Brugnara C. Am J Physiol1996 Mar270(3 Pt 1):C866-77http://www.ncbi.nlm.nih.gov/pubmed/8562946Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy. Blood. 1996 Feb 01; 87(3):1188-95.de Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y. Blood1996 Feb 0187(3):1188-95http://www.ncbi.nlm.nih.gov/pubmed/8925867Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites. Eur J Pharmacol. 1996 Jan 04; 295(1):109-12.Coupry I, Armsby CC, Alper SL, Brugnara C, Parini A. Eur J Pharmacol1996 Jan 04295(1):109-12http://www.ncbi.nlm.nih.gov/pubmed/8594870Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Am J Physiol. 1995 Dec; 269(6 Pt 2):F761-74.Breton S, Alper SL, Gluck SL, Sly WS, Barker JE, Brown D. Am J Physiol1995 Dec269(6 Pt 2):F761-74http://www.ncbi.nlm.nih.gov/pubmed/8606369Overexpression of AE1 Prague, but not of AE1 SAO, inhibits wild-type AE1 trafficking in Xenopus oocytes. J Membr Biol. 1995 Nov; 148(2):203-10.Chernova MN, Jarolim P, Palek J, Alper SL. J Membr Biol1995 Nov148(2):203-10http://www.ncbi.nlm.nih.gov/pubmed/7570023Activation of cell-specific transcription by a serine phosphatase at the site of asymmetric division. Science. 1995 Oct 27; 270(5236):641-4.Duncan L, Alper S, Arigoni F, Losick R, Stragier P. Science1995 Oct 27270(5236):641-4http://www.ncbi.nlm.nih.gov/pubmed/7592657Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo. J Biol Chem. 1995 Oct 13; 270(41):24428-34.Zhao Y, Chauvet PJ, Alper SL, Baltz JM. J Biol Chem1995 Oct 13270(41):24428-34http://www.ncbi.nlm.nih.gov/pubmed/7485530Regional and segmental localization of AE2 anion exchanger mRNA and protein in rat kidney. Am J Physiol. 1995 Oct; 269(4 Pt 2):F461-8.Brosius FC, Nguyen K, Stuart-Tilley AK, Haller C, Briggs JP, Alper SL. Am J Physiol1995 Oct269(4 Pt 2):F461-8http://www.ncbi.nlm.nih.gov/pubmed/7677496Aortic regurgitation in coronary artery bypass grafting: implications for cardioplegia administration. Ann Thorac Surg. 1995 Sep; 60(3):665-8.Moisa RB, Zeldis SM, Alper SA, Scott WC. Ann Thorac Surg1995 Sep60(3):665-8http://www.ncbi.nlm.nih.gov/pubmed/8531201Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins. J Membr Biol. 1995 Sep; 147(1):71-82.Brugnara C, Armsby CC, De Franceschi L, Crest M, Euclaire MF, Alper SL. J Membr Biol1995 Sep147(1):71-82http://www.ncbi.nlm.nih.gov/pubmed/7677336A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. Ann N Y Acad Sci. 1995 Jul 12; 763:262-71.Brugnara C, De Franceschi L, Armsby CC, Saadane N, Trudel M, Beuzard Y, Rittenhouse A, Rifai N, Platt O, Alper SL. Ann N Y Acad Sci1995 Jul 12763:262-71http://www.ncbi.nlm.nih.gov/pubmed/7677338Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites. Ann N Y Acad Sci. 1995 Jul 12; 763:287-9.Coupry I, Armsby CC, Alper S, Parini A, Brugnara C. Ann N Y Acad Sci1995 Jul 12763:287-9http://www.ncbi.nlm.nih.gov/pubmed/7714775Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity. J Pharmacol Exp Ther. 1995 Apr; 273(1):266-72.Brugnara C, Armsby CC, Sakamoto M, Rifai N, Alper SL, Platt O. J Pharmacol Exp Ther1995 Apr273(1):266-72http://www.ncbi.nlm.nih.gov/pubmed/7733237Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease. Am J Physiol. 1995 Apr; 268(4 Pt 1):C894-902.Armsby CC, Brugnara C, Alper SL. Am J Physiol1995 Apr268(4 Pt 1):C894-902http://www.ncbi.nlm.nih.gov/pubmed/7530501Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood. 1995 Feb 01; 85(3):634-40.Jarolim P, Rubin HL, Brabec V, Chrobak L, Zolotarev AS, Alper SL, Brugnara C, Wichterle H, Palek J. Blood1995 Feb 0185(3):634-40http://www.ncbi.nlm.nih.gov/pubmed/7840148Hypertonic activation of AE2 anion exchanger in Xenopus oocytes via NHE-mediated intracellular alkalinization. Am J Physiol. 1995 Jan; 268(1 Pt 1):C201-9.Humphreys BD, Jiang L, Chernova MN, Alper SL. Am J Physiol1995 Jan268(1 Pt 1):C201-9http://www.ncbi.nlm.nih.gov/pubmed/22358463Assessment of heterologous membrane protein polarity in transiently transfected MDCK cells. Cytotechnology. 1995 Jan; 17(2):71-82.Haller C, Alper SL. Cytotechnology1995 Jan17(2):71-82http://www.ncbi.nlm.nih.gov/pubmed/22358749Erratum Assessment of heterologous membrane protein polarity in transiently transfected MDCK cells. Cytotechnology. 1995 Jan; 18(3):235-48.Haller C, Alper SL. Cytotechnology1995 Jan18(3):235-48http://www.ncbi.nlm.nih.gov/pubmed/7894173Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Mamm Genome. 1994 Dec; 5(12):827-9.White RA, Geissler EN, Adkison LR, Dowler LL, Alper SL, Lux SE. Mamm Genome1994 Dec5(12):827-9http://www.ncbi.nlm.nih.gov/pubmed/7977693Functional characterization and regulation by pH of murine AE2 anion exchanger expressed in Xenopus oocytes. Am J Physiol. 1994 Nov; 267(5 Pt 1):C1295-307.Humphreys BD, Jiang L, Chernova MN, Alper SL. Am J Physiol1994 Nov267(5 Pt 1):C1295-307http://www.ncbi.nlm.nih.gov/pubmed/7923606Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. Circ Res. 1994 Oct; 75(4):603-14.Yannoukakos D, Stuart-Tilley A, Fernandez HA, Fey P, Duyk G, Alper SL. Circ Res1994 Oct75(4):603-14http://www.ncbi.nlm.nih.gov/pubmed/7849500Establishment of cell type specific gene transcription during sporulation in Bacillus subtilis. Curr Opin Genet Dev. 1994 Oct; 4(5):630-6.Duncan L, Alper S, Losick R. Curr Opin Genet Dev1994 Oct4(5):630-6http://www.ncbi.nlm.nih.gov/pubmed/7524338pHi and serum regulate AE2-mediated Cl-/HCO3- exchange in CHOP cells of defined transient transfection status. Am J Physiol. 1994 Sep; 267(3 Pt 1):C845-56.Jiang L, Stuart-Tilley A, Parkash J, Alper SL. Am J Physiol1994 Sep267(3 Pt 1):C845-56http://www.ncbi.nlm.nih.gov/pubmed/8037652Reducing disruptive behaviors by training students to request assistance. Behav Modif. 1994 Jul; 18(3):320-38.Jayne D, Schloss PJ, Alper S, Menscher S. Behav Modif1994 Jul18(3):320-38http://www.ncbi.nlm.nih.gov/pubmed/7995650Allergy to sodium hypochlorite during root canal therapy: a case report. Int Endod J. 1994 May; 27(3):163-7.Caliskan MK, Türkün M, Alper S. Int Endod J1994 May27(3):163-7http://www.ncbi.nlm.nih.gov/pubmed/8168129An adenosine nucleotide switch controlling the activity of a cell type-specific transcription factor in B. subtilis. Cell. 1994 Apr 22; 77(2):195-205.Alper S, Duncan L, Losick R. Cell1994 Apr 2277(2):195-205http://www.ncbi.nlm.nih.gov/pubmed/8056839The DNA binding domain of retinoic acid receptor beta is required for ligand-dependent suppression of proliferation. Application of general purpose mammalian coexpression vectors. J Cell Sci. 1994 Apr; 107 ( Pt 4):827-38.Frangioni JV, Moghal N, Stuart-Tilley A, Neel BG, Alper SL. J Cell Sci1994 Apr107 ( Pt 4):827-38http://www.ncbi.nlm.nih.gov/pubmed/8163647The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K(+)-ATPase rather than with basolateral anion exchanger AE2. J Clin Invest. 1994 Apr; 93(4):1430-8.Alper SL, Stuart-Tilley A, Simmons CF, Brown D, Drenckhahn D. J Clin Invest1994 Apr93(4):1430-8http://www.ncbi.nlm.nih.gov/pubmed/7512989Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest. 1994 Apr; 93(4):1670-6.De Franceschi L, Saadane N, Trudel M, Alper SL, Brugnara C, Beuzard Y. J Clin Invest1994 Apr93(4):1670-6http://www.ncbi.nlm.nih.gov/pubmed/8141271Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. Am J Physiol. 1994 Feb; 266(2 Pt 1):C559-68.Stuart-Tilley A, Sardet C, Pouyssegur J, Schwartz MA, Brown D, Alper SL. Am J Physiol1994 Feb266(2 Pt 1):C559-68http://www.ncbi.nlm.nih.gov/pubmed/8195690Using self-recording, evaluation, and graphing to increase completion of homework assignments. J Learn Disabil. 1994 Feb; 27(2):75-81.Trammel DL, Schloss PJ, Alper S. J Learn Disabil1994 Feb27(2):75-81http://www.ncbi.nlm.nih.gov/pubmed/8282779Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). J Clin Invest. 1994 Jan; 93(1):121-30.Jarolim P, Rubin HL, Liu SC, Cho MR, Brabec V, Derick LH, Yi SJ, Saad ST, Alper S, Brugnara C, et al. J Clin Invest1994 Jan93(1):121-30http://www.ncbi.nlm.nih.gov/pubmed/7694474Nonpolarized surface distribution and delivery of human CD7 in polarized MDCK cells. Am J Physiol. 1993 Oct; 265(4 Pt 1):C1069-79.Haller C, Alper SL. Am J Physiol1993 Oct265(4 Pt 1):C1069-79http://www.ncbi.nlm.nih.gov/pubmed/8326017Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993 Jul; 92(1):520-6.Brugnara C, de Franceschi L, Alper SL. J Clin Invest1993 Jul92(1):520-6http://www.ncbi.nlm.nih.gov/pubmed/8326877Extended school year programs: a community-driven curriculum model. Ment Retard. 1993 Jun; 31(3):163-70.Alper S, Parker K, Schloss P, Wisniewski L. Ment Retard1993 Jun31(3):163-70http://www.ncbi.nlm.nih.gov/pubmed/7682555Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins. J Biol Chem. 1993 Apr 25; 268(12):8760-8.Brugnara C, De Franceschi L, Alper SL. J Biol Chem1993 Apr 25268(12):8760-8http://www.ncbi.nlm.nih.gov/pubmed/1590432Colocalization of GAPDH and band 3 (AE1) proteins in rat erythrocytes and kidney intercalated cell membranes. Am J Physiol. 1992 May; 262(5 Pt 2):F892-6.Ercolani L, Brown D, Stuart-Tilley A, Alper SL. Am J Physiol1992 May262(5 Pt 2):F892-6http://www.ncbi.nlm.nih.gov/pubmed/1939644Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporter. J Clin Invest. 1991 Nov; 88(5):1553-8.Zhang R, Alper SL, Thorens B, Verkman AS. J Clin Invest1991 Nov88(5):1553-8http://www.ncbi.nlm.nih.gov/pubmed/2042971The band 3-related anion exchanger (AE) gene family. Annu Rev Physiol. 1991; 53:549-64.Alper SL. Annu Rev Physiol199153:549-64http://www.ncbi.nlm.nih.gov/pubmed/2526338Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33.Alper SL, Natale J, Gluck S, Lodish HF, Brown D. Proc Natl Acad Sci U S A1989 Jul86(14):5429-33http://www.ncbi.nlm.nih.gov/pubmed/2542243The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide. J Biol Chem. 1989 May 15; 264(14):7784-7.Brosius FC, Alper SL, Garcia AM, Lodish HF. J Biol Chem1989 May 15264(14):7784-7http://www.ncbi.nlm.nih.gov/pubmed/2649883A glucose transport protein expressed predominately in insulin-responsive tissues. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2535-9.Charron MJ, Brosius FC, Alper SL, Lodish HF. Proc Natl Acad Sci U S A1989 Apr86(8):2535-9http://www.ncbi.nlm.nih.gov/pubmed/3182834Cloning and characterization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem. 1988 Nov 15; 263(32):17092-9.Alper SL, Kopito RR, Libresco SM, Lodish HF. J Biol Chem1988 Nov 15263(32):17092-9http://www.ncbi.nlm.nih.gov/pubmed/3326961A molecular biological approach to the study of anion transport. Kidney Int Suppl. 1987 Dec; 23:S117-33.Alper SL, Kopito RR, Lodish HF. Kidney Int Suppl1987 Dec23:S117-33http://www.ncbi.nlm.nih.gov/pubmed/3317630Molecular biology of renal function: methods and applications. Semin Nephrol. 1987 Mar; 7(1):3-19.Alper SL. Semin Nephrol1987 Mar7(1):3-19http://www.ncbi.nlm.nih.gov/pubmed/6259269Protein phosphorylation and the regulation of cation cotransport. J Exp Biol. 1980 Dec; 89:103-15.Palfrey HC, Alper SL, Greengard P. J Exp Biol1980 Dec89:103-15http://www.ncbi.nlm.nih.gov/pubmed/6253498Hormonal control of protein phosphorylation in turkey erythrocytes. Phosphorylation by cAMP-dependent and Ca2+-dependent protein kinases of distinct sites in goblin, a high molecular weight protein of the plasma membrane. J Biol Chem. 1980 Nov 25; 255(22):11029-39.Alper SL, Palfrey HC, DeRiemer SA, Greengard P. J Biol Chem1980 Nov 25255(22):11029-39http://www.ncbi.nlm.nih.gov/pubmed/6154698Hormonal control of Na+-K+ co-transport in turkey erythrocytes. Multiple site phosphorylation of goblin, a high molecular weight protein of the plasma membrane. J Biol Chem. 1980 May 25; 255(10):4864-71.Alper SL, Beam KG, Greengard P. J Biol Chem1980 May 25255(10):4864-71http://www.ncbi.nlm.nih.gov/pubmed/229109Hormonally regulated phosphoprotein of turkey erythrocytes: localization to plasma membrane. J Cell Biol. 1979 Oct; 83(1):1-15.Beam KG, Alper SL, Palade GE, Greengard P. J Cell Biol1979 Oct83(1):1-15http://www.ncbi.nlm.nih.gov/pubmed/357989Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell. Nature. 1978 Sep 28; 275(5678):329-31.Sieghart W, Theoharides TC, Alper SL, Douglas WW, Greengard P. Nature1978 Sep 28275(5678):329-31http://www.ncbi.nlm.nih.gov/pubmed/648549The influence of academic information on teachers' judgments of vocational potential. Except Child. 1978 Apr; 44(7):537-8.Alper S, Retish PM. Except Child1978 Apr44(7):537-8http://www.ncbi.nlm.nih.gov/pubmed/858090On the pictorial properties of visual images: effects of image size on memory for words. Can J Psychol. 1977 Mar; 31(1):32-40.Kosslyn SM, Alper SN. Can J Psychol1977 Mar31(1):32-40http://www.ncbi.nlm.nih.gov/pubmed/596265The effects of a seven day camping experience on volunteer student counselors. Adolescence. 1977; 12(48):533-40.Alper S, Algozzine B. Adolescence197712(48):533-40http://www.ncbi.nlm.nih.gov/pubmed/4367974Microsomal synthesis of the ether analogs of triacylglycerols. Acyl CoA:alkylacylglycerol and acyl CoA:alk-i-enylacylglycerol acyltransferases in tumors and liver. Biochim Biophys Acta. 1974 Jun 26; 348(3):397-403.Blank ML, Wykle RL, Alper S, Snyder F. Biochim Biophys Acta1974 Jun 26348(3):397-403Antiporters848.385165324063834e+0001994-02-01T00:00:002016-06-16T00:00:00Anion Transport Proteins638.055964283786624e+0001994-02-01T00:00:002016-04-29T00:00:00Anion Exchange Protein 1, Erythrocyte435.193533065755676e+0001987-12-01T00:00:002022-09-01T00:00:00Chlorides584.889567901632180e+0001994-10-01T00:00:002024-01-15T00:00:00Anemia, Hemolytic, Congenital143.998858274343780e+0002009-11-11T00:00:002022-09-01T00:00:00Chloride-Bicarbonate Antiporters523.986044166428687e+0001994-09-01T00:00:002024-01-15T00:00:00Symporters243.803655839793358e+0001995-04-01T00:00:002022-07-18T00:00:00Erythrocytes483.548389386317413e+0001979-10-01T00:00:002022-12-01T00:00:00Oocytes482.848751099266492e+0001989-05-15T00:00:002022-07-01T00:00:00Intermediate-Conductance Calcium-Activated Potassium Channels152.711356569087089e+0001998-08-21T00:00:002025-10-22T00:00:00Bicarbonates322.485249775839373e+0001995-10-13T00:00:002016-04-29T00:00:00Anemia, Sickle Cell182.480352255236917e+0001993-07-01T00:00:002023-08-01T00:00:00Acidosis, Renal Tubular152.471455848024848e+0001998-03-13T00:00:002019-10-22T00:00:00Sulfate Transporters302.127108804587380e+0002000-11-01T00:00:002024-01-15T00:00:00Ion Channels142.106362676004169e+0001994-04-01T00:00:002024-05-24T00:00:00Potassium292.040495643367658e+0001979-10-01T00:00:002022-07-18T00:00:00Hydrops Fetalis92.029191696814964e+0002011-01-05T00:00:002022-09-01T00:00:00Hydrocephalus171.954194838873714e+0002017-07-10T00:00:002025-06-04T00:00:00Hydrogen-Ion Concentration531.873699335991488e+0001988-11-15T00:00:002024-01-15T00:00:00Membrane Transport Proteins161.798903431189621e+0002004-11-17T00:00:002015-10-20T00:00:00Ion Transport221.785031290429227e+0001995-07-12T00:00:002017-04-29T00:00:00Sulfates131.725807873837630e+0001996-03-01T00:00:002016-04-29T00:00:00SLC4A Proteins541.694325127413605e+0001994-02-01T00:00:002013-10-01T00:00:00Anions181.662274966496567e+0001987-12-01T00:00:002024-01-15T00:00:00Polycystic Kidney, Autosomal Dominant101.612953064856752e+0001997-05-01T00:00:002025-10-22T00:00:00Potassium Channel Blockers131.536186665122805e+0001995-04-01T00:00:002025-10-22T00:00:00Xenopus331.466975555668134e+0001994-11-01T00:00:002020-08-28T00:00:00Podocytes91.449446580369719e+0002010-06-24T00:00:002024-11-13T00:00:00Mutation, Missense161.380056007164721e+0002002-02-28T00:00:002023-11-17T00:00:00Membrane Proteins531.376018577751648e+0001979-10-01T00:00:002024-09-20T00:00:00K Cl- Cotransporters241.280013461122591e+0001995-04-01T00:00:002022-07-18T00:00:00Apolipoproteins71.227711889182060e+0002014-05-07T00:00:002024-08-23T00:00:00Apolipoprotein L1141.225453916290681e+0002014-05-07T00:00:002024-08-23T00:00:00Animals2551.134873966575881e+0001974-06-26T00:00:002025-10-22T00:00:00Kidney Diseases131.095231175534158e+0001999-08-01T00:00:002024-11-25T00:00:00Lipoproteins, HDL71.069614353534265e+0002014-05-07T00:00:002024-08-23T00:00:00Xenopus laevis241.064833107030723e+0001989-05-15T00:00:002022-07-01T00:00:00Mutation611.060941127728129e+0001994-01-01T00:00:002025-02-24T00:00:00Calcium389.883469819956928e-0011978-09-28T00:00:002021-11-20T00:00:00Mice1379.674964617957961e-0011988-11-15T00:00:002025-10-22T00:00:00Potassium Channels149.650029785742360e-0011993-04-25T00:00:002008-08-01T00:00:00Glomerulosclerosis, Focal Segmental89.287943602011310e-0012014-08-06T00:00:002024-11-13T00:00:00Sodium-Hydrogen Exchangers179.155044465913020e-0011994-02-01T00:00:002013-10-01T00:00:00Cations98.983652454331029e-0011995-04-01T00:00:002022-02-16T00:00:00Protein Structure, Tertiary258.922428235857925e-0012001-10-01T00:00:002015-06-24T00:00:00Cloning, Molecular248.913751986553258e-0011987-12-01T00:00:002016-04-01T00:00:00Amino Acid Substitution128.893845863947798e-0012002-11-01T00:00:002016-05-05T00:00:00Peritoneal Dialysis58.819005663544768e-0012012-12-31T00:00:002021-12-10T00:00:00Spherocytosis, Hereditary68.625430466186361e-0011994-01-01T00:00:002021-10-01T00:00:00Receptors, Purinergic P228.617733409503099e-0012022-07-01T00:00:002022-12-06T00:00:00Molecular Sequence Data558.502602208253693e-0011987-12-01T00:00:002015-06-24T00:00:00Zebrafish78.358470953077062e-0012003-05-01T00:00:002016-01-01T00:00:00Potassium, Dietary18.310249801239468e-0012024-05-24T00:00:002024-05-24T00:00:00Amino Acid Sequence438.203804461361739e-0011988-11-15T00:00:002016-04-01T00:00:00Clotrimazole147.873436541011355e-0011993-07-01T00:00:001998-08-21T00:00:00Genes, Dominant67.782735302483883e-0011998-03-13T00:00:002013-02-14T00:00:00Kidney367.779542274747510e-0011987-03-01T00:00:002025-10-22T00:00:00Reticulocytes67.680098132251875e-0011994-01-01T00:00:002022-02-16T00:00:00Glycophorins47.675370224973250e-0011998-12-15T00:00:002011-04-01T00:00:00Cell Membrane277.601116903386804e-0011991-01-01T00:00:002019-07-02T00:00:004,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid167.532504601240643e-0011994-11-01T00:00:002011-11-16T00:00:00Ketoglutaric Acids17.269885442023933e-0012022-07-01T00:00:002022-07-01T00:00:00Membrane Potentials157.233147887189568e-0011997-03-01T00:00:002019-05-15T00:00:00Receptors, Erythropoietin17.139865681493264e-0012022-03-01T00:00:002022-03-01T00:00:00Gain of Function Mutation47.107454290846439e-0012017-04-29T00:00:002024-11-13T00:00:00Triphenylmethyl Compounds37.085019722105788e-0012015-10-12T00:00:002025-10-22T00:00:00TRPA1 Cation Channel17.037206326445641e-0012021-10-29T00:00:002021-10-29T00:00:00DNA, Complementary196.945701273291841e-0011994-10-01T00:00:002007-11-28T00:00:00Peritoneal Fibrosis36.750438024368788e-0012012-12-31T00:00:002021-08-25T00:00:00TRPV Cation Channels26.695420276054312e-0012021-10-29T00:00:002021-11-20T00:00:00Calcium Signaling56.641422605807481e-0012001-05-01T00:00:002019-05-15T00:00:00Patch-Clamp Techniques126.541669823012843e-0011997-05-15T00:00:002017-04-29T00:00:00Biological Transport256.502362096257024e-0011979-10-01T00:00:002016-04-29T00:00:00Uromodulin46.482789343648848e-0012015-03-04T00:00:002024-12-16T00:00:00Zebrafish Proteins36.353711214766736e-0012012-10-11T00:00:002015-08-20T00:00:00Pancreatic Ducts36.159603234187203e-0012009-01-01T00:00:002011-05-18T00:00:00Integrases16.119700248797021e-0012022-03-01T00:00:002022-03-01T00:00:00Platelet Aggregation16.105895707565033e-0012022-11-01T00:00:002022-11-01T00:00:00Molecular Dynamics Simulation46.089295785768460e-0012011-12-22T00:00:002017-03-09T00:00:00Acetamides36.077383641140076e-0012015-10-12T00:00:002025-10-22T00:00:00Peritoneum46.059796751074064e-0012012-12-31T00:00:002021-08-25T00:00:00Membrane Glycoproteins66.000841770559919e-0012011-08-17T00:00:002024-12-16T00:00:00beta-Thalassemia35.992507240147210e-0011996-02-01T00:00:002019-11-25T00:00:00Sodium-Bicarbonate Symporters65.932754142061677e-0011999-12-01T00:00:002009-06-01T00:00:00Potassium Channels, Calcium-Activated65.925829486966228e-0011998-08-21T00:00:002009-05-03T00:00:00Cytoplasm135.913550297890219e-0011997-05-01T00:00:002013-07-22T00:00:00Oxalates55.903289729201927e-0012004-11-17T00:00:002016-04-29T00:00:00Osmotic Fragility55.767701825132711e-0012013-08-23T00:00:002019-11-25T00:00:00Carrier Proteins185.654821510032438e-0011987-03-01T00:00:002007-07-25T00:00:00Peptides145.628840968835100e-0011993-04-25T00:00:002010-01-15T00:00:00Solute Carrier Family 12, Member 275.556007023259603e-0012009-11-22T00:00:002022-07-18T00:00:00Hydrocephalus, Normal Pressure35.555670939089281e-0012020-01-18T00:00:002025-05-05T00:00:00Multigene Family65.537266448186453e-0011989-04-01T00:00:002013-04-01T00:00:00Calcium Channels45.399751462431082e-0012000-10-23T00:00:002010-01-15T00:00:00Formins35.391431379905859e-0012020-01-10T00:00:002024-11-13T00:00:00Neuroacanthocytosis35.379810364461888e-0012016-10-14T00:00:002025-04-24T00:00:00Mice, Knockout325.358723016633654e-0011996-09-20T00:00:002025-10-22T00:00:00Hyperuricemia25.356545600866920e-0012015-03-04T00:00:002018-03-07T00:00:00Adenosine Triphosphate85.286038455770924e-0011994-04-22T00:00:002022-02-16T00:00:00Erythrocyte Membrane135.231112918053228e-0011979-10-01T00:00:002010-01-15T00:00:00Cyclic GMP-Dependent Protein Kinase Type I15.214835010586827e-0012017-03-09T00:00:002017-03-09T00:00:00Vestibular Aqueduct75.214204467396955e-0012009-04-01T00:00:002015-10-20T00:00:00Hypertonic Solutions105.205742150017069e-0011995-01-01T00:00:002007-01-24T00:00:00Polymorphism, Genetic105.179871765815802e-0011995-02-01T00:00:002014-05-07T00:00:00Leucine Zippers15.167715513783766e-0012017-03-09T00:00:002017-03-09T00:00:00TRPP Cation Channels65.153431223245040e-0012000-10-23T00:00:002025-10-22T00:00:00Blood Proteins35.139055923605564e-0012011-08-17T00:00:002017-12-04T00:00:00Calcium Oxalate35.125109606648515e-0012011-11-02T00:00:002022-12-06T00:00:00Humans2405.031647990864178e-0011977-01-01T00:00:002025-10-22T00:00:00Chloride Channels55.013983342670726e-0011996-11-01T00:00:002005-08-18T00:00:00Neural Stem Cells64.895670991870812e-0012018-07-05T00:00:002025-06-04T00:00:00Heterozygote74.890080947684663e-0011998-03-13T00:00:002017-04-29T00:00:00Hyperkalemia34.842780186005805e-0012011-08-17T00:00:002016-05-05T00:00:00Quaternary Ammonium Compounds34.818386551006356e-0012002-01-01T00:00:002007-08-09T00:00:00Homozygote34.772730911118562e-0012010-10-01T00:00:002016-01-01T00:00:00Sodium144.723580247238595e-0011979-10-01T00:00:002022-12-01T00:00:00Dipeptides44.648441209852854e-0012016-10-21T00:00:002020-12-15T00:00:00Cilia44.615427059134607e-0012006-11-07T00:00:002024-06-25T00:00:00Myosins14.591073405879131e-0012017-03-09T00:00:002017-03-09T00:00:00Transfection184.490939203812652e-0011993-10-01T00:00:002015-12-23T00:00:00Gene Deletion84.477857876565211e-0011996-02-01T00:00:002021-10-29T00:00:00Gastric Mucosa84.474724744823432e-0011994-02-01T00:00:002009-09-01T00:00:00RNA, Messenger404.471118532275715e-0011988-11-15T00:00:002022-10-25T00:00:00Erythrocytes, Abnormal44.378839794848392e-0011993-07-01T00:00:002010-01-15T00:00:00Phenotype254.317631672449329e-0011997-01-01T00:00:002025-05-02T00:00:00Dialysis Solutions34.237063695719648e-0012016-10-21T00:00:002020-12-15T00:00:00HEK293 Cells134.197609234055749e-0012011-05-18T00:00:002025-04-28T00:00:00Protein Conformation74.196551686266893e-0011996-07-12T00:00:002016-05-05T00:00:00Nephrolithiasis24.111451119678959e-0012008-01-03T00:00:002022-12-06T00:00:00Ethylmaleimide24.101799048624914e-0012001-10-01T00:00:002013-03-06T00:00:00Cross-Linking Reagents44.093258028555415e-0011994-04-22T00:00:002009-05-01T00:00:00Oxalic Acid24.047105027346998e-0012009-11-11T00:00:002010-03-10T00:00:00Sequence Homology, Amino Acid113.995741519230597e-0011995-02-01T00:00:002016-04-01T00:00:00Vacuolar Proton-Translocating ATPases53.962082369031553e-0012001-04-01T00:00:002019-10-22T00:00:00Acid-Base Equilibrium63.960841927017648e-0011997-01-01T00:00:002013-03-22T00:00:00Genetic Predisposition to Disease173.878983105583540e-0012004-02-01T00:00:002024-11-25T00:00:00Pedigree133.868110902834730e-0011994-01-01T00:00:002018-12-18T00:00:00Hemolysis43.852660554612742e-0011996-03-01T00:00:002013-03-15T00:00:00Models, Molecular83.849831174475539e-0012003-07-01T00:00:002024-09-20T00:00:00Base Sequence303.846141618066290e-0011987-12-01T00:00:002012-10-11T00:00:00Acclimatization13.783888951667347e-0012013-03-22T00:00:002013-03-22T00:00:00Protein Structure, Secondary83.749737055772608e-0011994-04-01T00:00:002014-02-27T00:00:00Arnold-Chiari Malformation23.747898163925064e-0012023-10-04T00:00:002025-05-02T00:00:00Anemia33.743043294524862e-0012015-08-20T00:00:002019-11-25T00:00:00Sharks23.736369551275849e-0011998-01-01T00:00:002005-08-18T00:00:00Altitude Sickness13.699593642123208e-0012013-03-22T00:00:002013-03-22T00:00:00Intracellular Membranes103.691550423592405e-0011994-09-01T00:00:002004-04-30T00:00:00Alleles113.652214740971963e-0011995-02-01T00:00:002021-07-14T00:00:00Spider Venoms23.595396993869967e-0012000-05-01T00:00:002010-01-15T00:00:00Intestinal Mucosa93.588606972395705e-0011996-11-01T00:00:002016-06-16T00:00:00Protein Transport93.577204222930343e-0012003-03-26T00:00:002024-12-16T00:00:00Cells, Cultured243.571720869758499e-0011996-11-01T00:00:002022-02-16T00:00:00Structure-Activity Relationship123.544584956248651e-0011995-04-01T00:00:002016-05-05T00:00:00Glucose Transporter Type 113.538010424061774e-0012012-03-09T00:00:002012-03-09T00:00:00Endothelium, Vascular93.536159781850966e-0011997-06-01T00:00:002009-05-03T00:00:00Pyrazoles23.532958650413565e-0012008-08-01T00:00:002022-11-01T00:00:00Disease13.499214563630512e-0012017-02-28T00:00:002017-02-28T00:00:00Cystic Fibrosis Transmembrane Conductance Regulator73.478837342013756e-0012003-03-21T00:00:002016-06-16T00:00:00RNA, Complementary83.477457160860759e-0011994-10-01T00:00:002009-05-01T00:00:00Vesicular Transport Proteins33.465310198056005e-0012019-07-25T00:00:002025-04-24T00:00:00Kidney Tubules23.463445005529866e-0011989-07-01T00:00:002010-10-30T00:00:00Mice, Transgenic163.387319169617701e-0011994-04-01T00:00:002025-02-24T00:00:00Choroid Plexus33.383157285685230e-0011994-04-01T00:00:002023-02-16T00:00:00Recombinant Fusion Proteins153.367573081133382e-0011994-04-01T00:00:002015-12-23T00:00:00Imidazoles73.364456613774122e-0011993-07-01T00:00:002007-08-09T00:00:00Peptide Fragments83.355044270151874e-0011980-11-25T00:00:002020-01-10T00:00:00Cholinergic Antagonists13.322411192638335e-0012011-11-02T00:00:002011-11-02T00:00:00Rats453.309869545703918e-0011974-06-26T00:00:002025-04-28T00:00:00Carbonic Anhydrase II33.281391144975688e-0012003-08-21T00:00:002013-07-22T00:00:00Mucin-143.275958638361403e-0012013-02-10T00:00:002021-06-07T00:00:00Vein of Galen Malformations23.258758607073365e-0012018-12-18T00:00:002023-11-17T00:00:00Disease Models, Animal183.257434245550235e-0011995-07-12T00:00:002025-10-22T00:00:00Muscle, Smooth, Vascular73.253532819283767e-0011997-05-01T00:00:002017-03-09T00:00:00Parietal Cells, Gastric63.247324818943199e-0011996-08-01T00:00:002008-11-12T00:00:00Epithelial Cells123.210152286892253e-0011996-04-01T00:00:002021-08-25T00:00:00Cysteine23.202530361547543e-0012007-12-23T00:00:002012-12-28T00:00:00Dehydration33.189784400048722e-0012019-07-17T00:00:002022-12-01T00:00:00Amphibians13.151414197321888e-0012009-11-11T00:00:002009-11-11T00:00:00Mitogen-Activated Protein Kinases33.151071772848496e-0011998-12-01T00:00:002015-12-23T00:00:00Cerebrospinal Fluid33.134151834945880e-0012017-07-10T00:00:002025-02-24T00:00:00Cell Size113.125333380514167e-0011997-11-01T00:00:002019-07-17T00:00:00Bacterial Proteins93.117710398463161e-0011994-04-22T00:00:002011-12-22T00:00:004-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid43.082895970314875e-0011999-06-29T00:00:002010-01-28T00:00:00Sigma Factor63.041871371402931e-0011994-04-22T00:00:001996-07-12T00:00:00Kinetics153.035987259567903e-0011978-09-28T00:00:002011-05-18T00:00:00Protein Serine-Threonine Kinases93.033634471478265e-0011994-10-01T00:00:002020-01-07T00:00:00Urinary Bladder33.029118657715062e-0012020-08-28T00:00:002025-02-24T00:00:00Cell Hypoxia33.028018814598928e-0011997-07-01T00:00:002010-01-15T00:00:00Microscopy, Confocal83.012307363965393e-0011997-01-01T00:00:002014-03-26T00:00:00Bacillus subtilis72.978812641824575e-0011994-04-22T00:00:001996-07-12T00:00:00Cell Line252.950309757684762e-0011988-11-15T00:00:002016-05-05T00:00:00Proto-Oncogene Proteins c-bcl-212.943644265064763e-0012015-06-24T00:00:002015-06-24T00:00:00In Vitro Techniques152.929622369035327e-0011993-04-25T00:00:002017-04-29T00:00:00Female1182.920428026306699e-0011989-05-15T00:00:002025-10-22T00:00:00Conserved Sequence52.907690460604878e-0011995-02-01T00:00:002011-07-20T00:00:00Carbonic Anhydrases92.896564141328573e-0011994-02-01T00:00:002010-01-28T00:00:00Receptors, Purinergic12.887553862969701e-0012009-02-25T00:00:002009-02-25T00:00:00Transcription, Genetic172.875514821918646e-0011989-05-15T00:00:002013-12-18T00:00:00Chlorine22.861404868909305e-0012004-11-17T00:00:002005-08-18T00:00:00Cerebral Ventricles52.821275993839441e-0012017-07-10T00:00:002023-04-04T00:00:00Proton-Translocating ATPases52.811694070230991e-0011989-07-01T00:00:002001-04-01T00:00:00Mutagenesis72.807206999814126e-0011996-03-08T00:00:002011-11-16T00:00:00Signal Transduction202.793410269707370e-0011996-06-01T00:00:002025-10-22T00:00:00Endothelin-142.770380887280357e-0011997-11-01T00:00:002023-08-01T00:00:00Autophagy32.749973489013672e-0012016-10-14T00:00:002025-04-24T00:00:00Behcet Syndrome12.748825088910350e-0012009-03-01T00:00:002009-03-01T00:00:00Skin Diseases, Vesiculobullous12.736264197964057e-0012008-08-27T00:00:002008-08-27T00:00:00Species Specificity72.714146327213494e-0011996-03-01T00:00:002013-04-01T00:00:00Point Mutation32.711074577802361e-0011995-02-01T00:00:002010-10-01T00:00:00Hearing Loss, Sensorineural52.698105507611210e-0012011-02-24T00:00:002015-10-20T00:00:00Protein Multimerization32.696409618322644e-0012017-03-09T00:00:002024-09-20T00:00:00Hemoglobin, Sickle42.639173193155311e-0011994-04-01T00:00:002017-05-13T00:00:00Nephrology32.612136031814188e-0011987-03-01T00:00:002021-02-17T00:00:00Dihydropyridines22.605606059777039e-0011998-01-01T00:00:002025-04-28T00:00:00Scorpion Venoms32.585123236263530e-0011993-04-25T00:00:001999-12-01T00:00:00Erythrocyte Indices32.579633362884378e-0012012-03-09T00:00:002019-05-15T00:00:00Sodium-Potassium-Exchanging ATPase92.554643604902799e-0011980-05-25T00:00:002013-03-12T00:00:00Caenorhabditis elegans Proteins32.547082845894488e-0012001-05-01T00:00:002005-04-06T00:00:00Stress Fibers12.547046757149983e-0012006-12-27T00:00:002006-12-27T00:00:00Submandibular Gland32.521001270160762e-0011997-01-01T00:00:002002-03-23T00:00:00Nitric Oxide Synthase32.519861950500992e-0011999-01-08T00:00:001999-08-01T00:00:00Promoter Regions, Genetic72.507719924856835e-0011994-04-22T00:00:002022-03-01T00:00:00Antifungal Agents52.505512652418627e-0011996-11-01T00:00:001998-06-01T00:00:00Pemphigoid, Bullous12.504955773627852e-0012008-08-27T00:00:002008-08-27T00:00:00Myosin Type II12.494711793294846e-0012006-12-27T00:00:002006-12-27T00:00:00Histidine22.494505118505254e-0012004-09-27T00:00:002006-09-27T00:00:00Mutagenesis, Site-Directed82.488175260687610e-0011996-07-12T00:00:002007-02-16T00:00:00Mesylates32.468569894800954e-0012008-05-14T00:00:002011-11-16T00:00:00Parotid Gland52.461576284194886e-0011999-12-01T00:00:002007-09-21T00:00:00Saline Solution, Hypertonic12.449547067299589e-0012006-12-27T00:00:002006-12-27T00:00:00Carbon Monoxide12.448941706574281e-0012010-01-15T00:00:002010-01-15T00:00:00Circular Dichroism22.434369527948311e-0012016-04-01T00:00:002017-03-09T00:00:00Kidney Tubules, Collecting42.433865633719644e-0011989-07-01T00:00:002016-12-08T00:00:00Immunohistochemistry242.424038421425695e-0011994-02-01T00:00:002018-07-02T00:00:00Calcimycin52.422662582187137e-0011978-09-28T00:00:002022-07-18T00:00:00Male1082.415858136544000e-0011974-06-26T00:00:002025-10-22T00:00:00Urticaria12.395219026159227e-0012007-07-01T00:00:002007-07-01T00:00:00Immunoblotting122.392508663632359e-0011994-02-01T00:00:002017-07-10T00:00:00Egtazic Acid22.389031436567436e-0012001-12-01T00:00:002003-01-15T00:00:00Cyclic AMP112.367740926993719e-0011979-10-01T00:00:002012-07-16T00:00:00Mycobacterium tuberculosis42.330685108035319e-0012007-12-23T00:00:002011-12-22T00:00:00Tissue Distribution122.316045751574496e-0011989-04-01T00:00:002005-11-14T00:00:00Sterols12.310985483509712e-0012005-08-18T00:00:002005-08-18T00:00:00Vascular Diseases22.274078674643678e-0012023-08-01T00:00:002023-11-17T00:00:00Brain Edema32.266778682301167e-0012015-07-01T00:00:002020-09-20T00:00:00rhoA GTP-Binding Protein12.266703389053738e-0012006-12-27T00:00:002006-12-27T00:00:00Nasal Cavity12.264966199728596e-0012007-07-01T00:00:002007-07-01T00:00:00Proteins52.258365019193625e-0011978-09-28T00:00:002005-08-01T00:00:00Gene Expression Regulation, Developmental52.240939161758254e-0012002-07-01T00:00:002019-10-15T00:00:00Kidney Cortex42.220267994000219e-0011989-07-01T00:00:002006-11-07T00:00:00Genes, Helminth22.215156014157223e-0012001-05-01T00:00:002002-07-01T00:00:00Reverse Transcriptase Polymerase Chain Reaction82.214995642923766e-0012000-09-01T00:00:002014-03-26T00:00:00Actins52.204195298939285e-0011997-11-01T00:00:002020-06-15T00:00:00Aging, Premature12.201265804791231e-0012025-04-24T00:00:002025-04-24T00:00:00Muscle, Smooth32.179770701003455e-0012012-12-31T00:00:002025-02-24T00:00:00Secretory Pathway12.166780907578071e-0012024-09-20T00:00:002024-09-20T00:00:00Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization22.155642555015517e-0012016-04-01T00:00:002017-03-09T00:00:00Lisinopril12.143072395141504e-0012024-08-23T00:00:002024-08-23T00:00:00Caenorhabditis elegans32.138379303755696e-0012001-05-01T00:00:002005-04-06T00:00:00Alternative Splicing22.135809195867619e-0012001-03-19T00:00:002008-01-11T00:00:00Acids32.124976513658428e-0011997-04-01T00:00:002002-11-01T00:00:00Introns62.119636387953376e-0011989-05-15T00:00:002010-10-01T00:00:00Cerebral Aqueduct12.110184361881791e-0012024-04-04T00:00:002024-04-04T00:00:00Actinin22.109498371146290e-0012006-12-27T00:00:002020-06-15T00:00:00Melanosis12.101230481436923e-0012005-08-01T00:00:002005-08-01T00:00:00Genes, Homeobox22.099884757563167e-0012001-05-01T00:00:002002-07-01T00:00:00Ammonium Chloride42.091670721414082e-0011997-04-01T00:00:002004-12-01T00:00:00Apyrase22.086722732055527e-0012009-02-25T00:00:002022-02-16T00:00:00Neurodevelopmental Disorders22.079551112727551e-0012021-10-05T00:00:002024-12-03T00:00:00ATP-Binding Cassette Transporters32.078223214138650e-0012012-11-24T00:00:002022-09-01T00:00:00Lower Urinary Tract Symptoms12.064054880231181e-0012025-02-24T00:00:002025-02-24T00:00:00Blotting, Northern72.041374255508340e-0011994-10-01T00:00:002004-04-30T00:00:00Hypertension42.039534129873765e-0011995-09-01T00:00:002018-03-07T00:00:00Ionophores42.031214019394740e-0011997-05-15T00:00:002011-01-05T00:00:00Phosphorylation192.017763896900411e-0011978-09-28T00:00:002020-06-15T00:00:00Gene Expression Profiling52.003291185036870e-0012001-03-19T00:00:002017-07-24T00:00:00Mice, Inbred C57BL261.996263550651601e-0011994-04-01T00:00:002025-04-24T00:00:00Neurogenesis41.988812233184759e-0012020-10-19T00:00:002025-06-04T00:00:00Transcription Factors151.977753190159406e-0011994-04-22T00:00:002025-05-13T00:00:00Cranial Sutures11.968733728860144e-0012023-10-27T00:00:002023-10-27T00:00:00Mannitol21.968475996769524e-0011998-12-01T00:00:002006-12-27T00:00:00Ouabain41.953432012880219e-0011995-04-01T00:00:002011-01-05T00:00:00Topoisomerase I Inhibitors11.939107950540954e-0012003-07-01T00:00:002003-07-01T00:00:005'-Nucleotidase11.931106568199688e-0012024-01-31T00:00:002024-01-31T00:00:00Blotting, Western131.930169547916265e-0011989-07-01T00:00:002017-07-10T00:00:00Rabbits141.928436088742840e-0011991-11-01T00:00:002001-08-01T00:00:00Diarrhea41.928151346642027e-0011997-12-15T00:00:002024-01-15T00:00:00Bumetanide71.927717182650829e-0011995-04-01T00:00:002017-07-10T00:00:00Haplotypes51.909434900595090e-0011998-03-13T00:00:002021-07-14T00:00:00Chromosomes, Human, Pair 221.901906811618436e-0011994-10-01T00:00:002012-11-24T00:00:00Recombinant Proteins101.899781486222434e-0011996-02-01T00:00:002019-09-26T00:00:00src-Family Kinases41.896334809889200e-0012001-10-01T00:00:002021-05-03T00:00:00Acetic Acid11.880376656682629e-0012022-07-18T00:00:002022-07-18T00:00:00Permeability21.875934716391020e-0012000-10-23T00:00:002021-10-01T00:00:00Arachnoid Cysts11.863062077603713e-0012023-03-06T00:00:002023-03-06T00:00:00Cattle91.861675925068430e-0011997-06-01T00:00:002006-12-27T00:00:00Protein Binding121.858163991924058e-0011994-04-01T00:00:002024-09-20T00:00:00Suramin11.856890002617396e-0012022-02-16T00:00:002022-02-16T00:00:00Fluorescent Antibody Technique101.855275874691321e-0011989-07-01T00:00:002010-06-24T00:00:00Protein Subunits31.855106948252539e-0012003-08-21T00:00:002009-03-14T00:00:00Alkalies41.850859417409748e-0011995-01-01T00:00:001997-05-01T00:00:00Acidosis31.847551133106278e-0011997-01-01T00:00:002016-11-01T00:00:00Probenecid11.835963274901471e-0012022-02-16T00:00:002022-02-16T00:00:00Isoxazoles21.829844845067615e-0011998-01-01T00:00:002008-05-14T00:00:00Magnesium51.828894176180014e-0011996-03-01T00:00:002022-12-01T00:00:00Hemodiafiltration11.818794073544271e-0012021-12-10T00:00:002021-12-10T00:00:00Lipid Droplets21.789981562535080e-0012019-02-07T00:00:002022-03-01T00:00:00Crystallins11.776792617411900e-0012021-08-25T00:00:002021-08-25T00:00:00Thermosensing11.775093292795848e-0012021-11-20T00:00:002021-11-20T00:00:00Gene Expression Regulation151.774595214851299e-0011987-03-01T00:00:002014-08-06T00:00:00Natriuretic Peptides21.754691379279995e-0012011-11-30T00:00:002013-12-18T00:00:00Hypoxia31.754652670497455e-0012003-03-28T00:00:002022-02-16T00:00:00Codon51.754072153779968e-0011995-02-01T00:00:002016-05-05T00:00:00PTEN Phosphohydrolase21.753005834691535e-0012021-10-05T00:00:002025-02-24T00:00:00Gene Regulatory Networks21.744734271386076e-0012013-02-13T00:00:002025-05-13T00:00:00Guinea Pigs51.736363142164405e-0011997-12-01T00:00:002011-05-18T00:00:00Amiloride41.728360596515544e-0012000-05-01T00:00:002013-03-06T00:00:00Erythroid Cells21.720135095079314e-0012007-10-01T00:00:002016-10-14T00:00:00Apolipoproteins L21.699099737504903e-0012015-05-01T00:00:002018-02-01T00:00:00Chromosome Mapping61.696342122330737e-0011994-10-01T00:00:002012-10-11T00:00:00Plasminogen11.693108774695769e-0012001-05-01T00:00:002001-05-01T00:00:00Enzyme Inhibitors61.682047978532286e-0012000-10-01T00:00:002020-01-07T00:00:00Anaphylaxis21.675435622311688e-0012016-11-01T00:00:002019-03-13T00:00:00Platelet Function Tests11.674520680874051e-0012022-11-01T00:00:002022-11-01T00:00:00DNA Mutational Analysis81.666427279387764e-0011998-12-15T00:00:002019-10-22T00:00:00Multiomics11.658871799204519e-0012023-03-06T00:00:002023-03-06T00:00:00Dinucleotide Repeats11.654466859678043e-0012000-07-24T00:00:002000-07-24T00:00:00Rats, Wistar91.649104775884459e-0011997-01-01T00:00:002019-03-13T00:00:00Protein Biosynthesis51.645644423309963e-0011995-11-01T00:00:002002-02-28T00:00:00Carcinoma, Medullary11.636272872830466e-0012021-07-14T00:00:002021-07-14T00:00:00Autism Spectrum Disorder31.631502471066221e-0012021-10-05T00:00:002024-06-25T00:00:00Rubidium Radioisotopes31.630767411873896e-0012004-09-03T00:00:002009-11-11T00:00:00Cation Transport Proteins71.626388323662604e-0011997-06-01T00:00:002013-10-01T00:00:00Water-Electrolyte Balance51.620036788587117e-0011993-07-01T00:00:002013-03-22T00:00:00Polyamines21.615745457950672e-0011997-04-01T00:00:001998-01-01T00:00:00Leukemia, Erythroblastic, Acute21.614847120546132e-0011997-05-15T00:00:001998-08-21T00:00:00Adenosine Deaminase11.605375580156175e-0012022-10-25T00:00:002022-10-25T00:00:00Cytoprotection11.604147919779244e-0012020-12-15T00:00:002020-12-15T00:00:00Helminth Proteins11.602809016844831e-0012001-05-01T00:00:002001-05-01T00:00:00Gastric Acid31.599145683059637e-0012003-06-01T00:00:002009-09-01T00:00:00Microscopy, Fluorescence81.569531589004769e-0011997-10-01T00:00:002011-05-18T00:00:00Muscle Contraction11.567969315900586e-0012025-02-24T00:00:002025-02-24T00:00:004-Aminopyridine21.560050066076166e-0011997-07-01T00:00:002016-11-01T00:00:00Hearing Loss31.557729479901807e-0012009-04-01T00:00:002015-10-20T00:00:00Heptanes11.556435190096615e-0012019-07-25T00:00:002019-07-25T00:00:00Actin Cytoskeleton31.556345413310650e-0011997-11-01T00:00:002024-11-13T00:00:00Albuminuria31.546977786656000e-0012010-06-24T00:00:002020-06-15T00:00:00TRPC6 Cation Channel11.545371357534152e-0012019-07-02T00:00:002019-07-02T00:00:00Bridged Bicyclo Compounds11.542829207272453e-0012019-07-25T00:00:002019-07-25T00:00:00Nephritis, Interstitial11.540012470134037e-0012021-06-07T00:00:002021-06-07T00:00:00Genetic Diseases, X-Linked11.539018911923795e-0012024-04-04T00:00:002024-04-04T00:00:00Meiosis21.538919499962389e-0012009-10-12T00:00:002013-10-01T00:00:00Cell Polarity51.535470440110874e-0011993-10-01T00:00:002010-10-30T00:00:00Protein Folding11.534803883095151e-0012024-09-20T00:00:002024-09-20T00:00:00Genetic Background11.524321732150745e-0012019-08-01T00:00:002019-08-01T00:00:00Staphylococcus aureus21.523072771348940e-0011980-05-25T00:00:002007-07-01T00:00:00Osmolar Concentration51.515455499792632e-0011996-08-13T00:00:002003-09-04T00:00:00Touch11.514699943971148e-0012021-11-20T00:00:002021-11-20T00:00:00Trypanosoma brucei rhodesiense21.514338193391465e-0012014-05-07T00:00:002016-04-01T00:00:00Camptothecin11.512066352585758e-0012003-07-01T00:00:002003-07-01T00:00:00Craniosynostoses11.501796271346001e-0012023-10-27T00:00:002023-10-27T00:00:00Microtubules21.493454404957274e-0011999-02-01T00:00:002024-06-25T00:00:00Models, Biological121.491763068618048e-0011994-04-22T00:00:002020-12-15T00:00:00Gene Expression141.490425079380706e-0011995-10-13T00:00:002016-05-05T00:00:00Protein Isoforms61.485303978121638e-0012000-10-01T00:00:002020-01-10T00:00:00Adiponectin11.482430794462561e-0012025-02-24T00:00:002025-02-24T00:00:00Splenomegaly11.482271778912544e-0012019-11-25T00:00:002019-11-25T00:00:00Genotype131.473141702741392e-0012008-01-11T00:00:002021-07-14T00:00:00Erythrocyte Deformability31.472353567759938e-0011996-02-01T00:00:002017-04-29T00:00:00Protein Kinase C21.472117384763230e-0012010-03-10T00:00:002016-04-29T00:00:00Diuretics, Osmotic11.466252260843886e-0011998-12-01T00:00:001998-12-01T00:00:00Hydrocarbons, Chlorinated11.459172537324166e-0012020-01-07T00:00:002020-01-07T00:00:00Exome Sequencing61.457462050910381e-0012018-07-05T00:00:002022-04-04T00:00:00Lysosomes31.456174178073655e-0012016-10-14T00:00:002019-07-25T00:00:00Thalassemia11.452366366698737e-0011999-11-01T00:00:001999-11-01T00:00:00Glucosides11.450839862170337e-0012024-08-23T00:00:002024-08-23T00:00:00Stress, Mechanical41.446907574011253e-0011999-01-08T00:00:002009-02-25T00:00:00Sodium-Potassium-Chloride Symporters51.430777377784973e-0011996-03-01T00:00:002016-10-26T00:00:00Alkalosis21.428865993224660e-0011997-01-01T00:00:002004-12-01T00:00:00Child221.425274289910833e-0011977-01-01T00:00:002025-05-13T00:00:00Benzimidazoles21.416912160599021e-0012003-07-01T00:00:002008-08-01T00:00:00Endothelial Cells31.415293750664842e-0012006-12-27T00:00:002023-11-17T00:00:00Animals, Newborn61.406120169141785e-0011997-05-15T00:00:002019-10-15T00:00:00Pancreas31.405720013850921e-0011974-06-26T00:00:002002-03-23T00:00:00Glycosylation51.402597819062017e-0011996-08-01T00:00:002019-07-02T00:00:00Mitochondrial Membrane Transport Proteins11.400069444476176e-0012019-09-26T00:00:002019-09-26T00:00:00In Situ Hybridization41.399265598318470e-0011998-11-11T00:00:002014-03-26T00:00:00Case-Control Studies81.397237589564295e-0012004-02-01T00:00:002021-06-07T00:00:00Kidney Glomerulus31.395624064323061e-0012010-06-24T00:00:002023-04-12T00:00:00Ankyrins31.387917800910691e-0011980-05-25T00:00:002013-07-22T00:00:00Interferon Type I11.374988969961818e-0012022-10-25T00:00:002022-10-25T00:00:00Education of Persons with Intellectual Disabilities21.374751548606356e-0011978-04-01T00:00:001993-06-01T00:00:00Arabidopsis31.368234187087533e-0011999-02-16T00:00:002013-04-01T00:00:00Glymphatic System11.367599019984584e-0012020-01-18T00:00:002020-01-18T00:00:00Protein Domains21.351270684111379e-0012017-03-09T00:00:002024-09-20T00:00:00Adenosine Diphosphate31.341824835900319e-0011994-04-22T00:00:001996-07-12T00:00:00Angiotensin-Converting Enzyme Inhibitors11.339161213125264e-0012024-08-23T00:00:002024-08-23T00:00:00Tripartite Motif Proteins31.338412249841144e-0012020-10-19T00:00:002024-12-03T00:00:00Escherichia coli31.336490363850025e-0011996-07-12T00:00:002007-12-23T00:00:00Moyamoya Disease11.323749082350262e-0012021-08-01T00:00:002021-08-01T00:00:00Myocardium41.321508159966218e-0011994-10-01T00:00:002007-07-25T00:00:00Brain141.317421881301853e-0011997-12-01T00:00:002025-06-04T00:00:00Potassium Chloride31.315757240676482e-0012004-07-19T00:00:002007-10-01T00:00:00Ovalbumin11.305950522440143e-0012019-03-13T00:00:002019-03-13T00:00:00Densitometry11.305001162110663e-0011997-06-01T00:00:001997-06-01T00:00:00Ion Channel Gating41.299916880835388e-0011993-07-01T00:00:002005-08-18T00:00:00Human Umbilical Vein Endothelial Cells11.299695526416820e-0012020-12-15T00:00:002020-12-15T00:00:00Benzhydryl Compounds11.299472382938427e-0012024-08-23T00:00:002024-08-23T00:00:00Spectrophotometry, Ultraviolet11.295809716329573e-0012017-03-09T00:00:002017-03-09T00:00:00Polymorphism, Single Nucleotide61.290254289673478e-0012011-10-31T00:00:002024-11-25T00:00:00Antigens, CD41.274221652327149e-0011993-10-01T00:00:002009-02-25T00:00:00Receptors, Cell Surface21.271457404555426e-0012002-01-01T00:00:002005-08-18T00:00:00Muscle, Skeletal31.271144944658940e-0012008-08-01T00:00:002025-04-24T00:00:00Arterioles31.267113082723978e-0012008-09-30T00:00:002020-12-15T00:00:00RNA Splicing21.266810997247478e-0011998-06-01T00:00:002000-01-01T00:00:00Sodium Chloride51.265568017760621e-0011998-09-01T00:00:002010-03-10T00:00:00Serine31.263476760648961e-0012005-08-01T00:00:002020-06-15T00:00:00Exons41.260653677781665e-0011989-05-15T00:00:002011-10-31T00:00:00Glyceraldehyde-3-Phosphate Dehydrogenases21.254822624356076e-0011992-05-01T00:00:001997-06-01T00:00:00Ubiquitins11.238359590102953e-0012018-03-12T00:00:002018-03-12T00:00:00Hypotonic Solutions51.238170445700412e-0011995-01-01T00:00:002004-11-17T00:00:00Ion Exchange41.234201112526570e-0011991-01-01T00:00:002007-02-16T00:00:00Static Electricity11.234075913094477e-0012017-03-09T00:00:002017-03-09T00:00:00Rubidium31.226955446900919e-0011995-09-01T00:00:002011-01-05T00:00:00Colon51.224663171283369e-0011996-11-01T00:00:002010-01-28T00:00:00Collagen21.219219791512116e-0012001-05-01T00:00:002002-01-01T00:00:00Renin21.218840324352416e-0012001-03-01T00:00:002013-03-22T00:00:00Drug Development11.217246900958287e-0012020-09-20T00:00:002020-09-20T00:00:00Skin Neoplasms41.211849189099771e-0012002-05-01T00:00:002003-02-01T00:00:00Glomerulonephritis11.207172041998934e-0012018-02-01T00:00:002018-02-01T00:00:00Thiosulfates11.206130704496619e-0012016-04-29T00:00:002016-04-29T00:00:00Kidney Medulla31.205602486029042e-0011997-10-01T00:00:002009-09-01T00:00:00Encephalitis11.202124167683112e-0012020-03-09T00:00:002020-03-09T00:00:00MAP Kinase Signaling System31.202003241969914e-0012009-10-12T00:00:002015-12-23T00:00:00Kidney Failure, Chronic21.201660486688474e-0012018-02-01T00:00:002019-09-26T00:00:00Sodium Dodecyl Sulfate11.201038377050921e-0011996-04-01T00:00:001996-04-01T00:00:00RNA Interference51.200943750289840e-0012011-05-18T00:00:002019-09-26T00:00:00Photochemotherapy11.193255026003696e-0012002-05-01T00:00:002002-05-01T00:00:00Trophozoites11.192733391269220e-0012015-10-12T00:00:002015-10-12T00:00:00Gene Knockout Techniques21.190104132425130e-0012015-08-20T00:00:002017-07-10T00:00:00Electrophoresis, Polyacrylamide Gel51.181731240856228e-0011996-07-12T00:00:002009-05-01T00:00:00Plasmodium yoelii11.179256197073060e-0012015-10-12T00:00:002015-10-12T00:00:00Hydrophobic and Hydrophilic Interactions11.177680196107410e-0012017-03-09T00:00:002017-03-09T00:00:00Binding Sites81.173852656119505e-0011994-04-01T00:00:002019-10-15T00:00:00Acetazolamide41.166846642430540e-0012003-09-04T00:00:002017-07-10T00:00:00Electric Conductivity41.162254637585671e-0011997-07-01T00:00:002008-03-10T00:00:00Biological Transport, Active41.159398126812565e-0011980-05-25T00:00:002005-08-18T00:00:00Hypokalemia21.153853495074239e-0012001-03-01T00:00:002010-11-01T00:00:00Microcirculation31.149661888922302e-0011997-12-01T00:00:002008-09-30T00:00:00Plasmodium knowlesi11.147831874178184e-0012015-10-12T00:00:002015-10-12T00:00:00Magnetic Resonance Spectroscopy31.138668568565739e-0012009-03-14T00:00:002017-03-09T00:00:00Dogs51.134808530874421e-0011995-10-01T00:00:002012-03-09T00:00:00Child, Preschool131.133269551463781e-0011998-12-15T00:00:002025-05-13T00:00:00Chromatography, Ion Exchange21.129196196506440e-0012004-11-17T00:00:002005-11-14T00:00:00Erythropoiesis31.119956435361181e-0012003-05-01T00:00:002016-10-14T00:00:00Protein Processing, Post-Translational21.119869727499973e-0012015-12-23T00:00:002020-06-15T00:00:00Goiter, Nodular21.118316127159082e-0012011-02-24T00:00:002011-11-16T00:00:00Exome51.115775494544839e-0012016-05-05T00:00:002023-03-06T00:00:00Cardiopulmonary Bypass31.114009265409770e-0012008-08-01T00:00:002009-05-03T00:00:00Mice, Inbred Strains51.112310964524618e-0011995-04-01T00:00:002010-01-28T00:00:003' Untranslated Regions31.104213135967709e-0011999-11-01T00:00:002022-10-25T00:00:00Antigens, Differentiation, T-Lymphocyte21.099358206522315e-0011993-10-01T00:00:001994-09-01T00:00:00Aldosterone31.097687322996561e-0012000-11-01T00:00:002023-08-01T00:00:00Genome21.095143028172200e-0011997-01-01T00:00:002000-07-24T00:00:00GTP-Binding Proteins11.094641365562697e-0011999-01-08T00:00:001999-01-08T00:00:00Blood Physiological Phenomena11.091197133512467e-0011994-09-01T00:00:001994-09-01T00:00:00Ions21.088954851751245e-0012012-03-09T00:00:002012-10-11T00:00:00Colforsin61.087506727120555e-0011997-11-01T00:00:002010-01-28T00:00:00Root Canal Irrigants11.086255001058775e-0011994-05-01T00:00:001994-05-01T00:00:005' Untranslated Regions31.084323950625042e-0011999-11-01T00:00:002001-03-19T00:00:00Nervous System Diseases21.081654862545329e-0012015-06-11T00:00:002015-07-01T00:00:00Intracellular Fluid31.081647968154370e-0011996-02-01T00:00:002012-07-16T00:00:00Aminoglycosides21.080823037115355e-0012009-04-22T00:00:002012-10-11T00:00:00Nitriles11.077857713969709e-0012020-01-07T00:00:002020-01-07T00:00:00Portal Vein11.075752002844932e-0011997-07-01T00:00:001997-07-01T00:00:00Rats, Sprague-Dawley131.071114670407962e-0011996-04-01T00:00:002009-11-22T00:00:00Underachievement11.070602439977370e-0011994-02-01T00:00:001994-02-01T00:00:00Sodium Hypochlorite11.069598118469472e-0011994-05-01T00:00:001994-05-01T00:00:00Sodium Potassium Chloride Symporter Inhibitors31.064861606518909e-0012007-10-01T00:00:002012-07-16T00:00:00Chromosome Segregation11.063034784267943e-0012015-10-20T00:00:002015-10-20T00:00:00Trypanosomiasis, African11.063011013236046e-0012014-05-07T00:00:002014-05-07T00:00:00Severity of Illness Index21.062678557676603e-0012009-03-01T00:00:002009-11-11T00:00:00Loss of Function Mutation11.059162846043998e-0012017-02-28T00:00:002017-02-28T00:00:00Chromatin Assembly and Disassembly11.058735147930786e-0012018-12-18T00:00:002018-12-18T00:00:00Monitoring, Physiologic11.057155504135895e-0012021-12-10T00:00:002021-12-10T00:00:00Infant91.055676295745291e-0011998-12-15T00:00:002025-05-13T00:00:00Brain Diseases11.055146130485905e-0012023-10-04T00:00:002023-10-04T00:00:00Adult361.051155930086015e-0011977-01-01T00:00:002025-05-02T00:00:00Ketamine11.050834968912255e-0012020-08-28T00:00:002020-08-28T00:00:00Mice, Mutant Strains51.050615835373534e-0011996-02-01T00:00:002010-11-04T00:00:00Cations, Monovalent11.035717977719404e-0012013-08-23T00:00:002013-08-23T00:00:00Sequence Alignment51.034893763418692e-0011998-11-11T00:00:002012-10-11T00:00:00Glucuronosyltransferase11.028680309557748e-0012014-07-21T00:00:002014-07-21T00:00:00Gene Duplication11.023528865467162e-0012015-05-01T00:00:002015-05-01T00:00:00Sodium-Hydrogen Exchanger 151.014431217155279e-0012007-07-25T00:00:002013-10-01T00:00:00Molecular Weight41.009801387408258e-0011978-09-28T00:00:002016-10-14T00:00:00Toll-Like Receptor 411.006554367814955e-0012017-07-10T00:00:002017-07-10T00:00:00GPI-Linked Proteins29.977956354733092e-0022006-11-07T00:00:002024-01-31T00:00:00Phosphatidylinositol 3-Kinases29.960430346185623e-0021999-01-08T00:00:002021-10-05T00:00:00Hyperoxaluria29.959847670802136e-0022008-01-03T00:00:002016-06-16T00:00:00Receptors, Retinoic Acid19.949720776829270e-0021994-04-01T00:00:001994-04-01T00:00:00Benzamides19.903892818086151e-0022019-07-25T00:00:002019-07-25T00:00:00Nuclear Magnetic Resonance, Biomolecular19.900146792575709e-0022016-04-01T00:00:002016-04-01T00:00:00Gastrointestinal Hormones19.885598627133085e-0022013-12-18T00:00:002013-12-18T00:00:00Cell Count19.880072036118394e-0022017-04-29T00:00:002017-04-29T00:00:00Drug Resistance39.859088855359216e-0021995-04-01T00:00:002013-03-06T00:00:00Vacuoles49.831280709042300e-0021989-07-01T00:00:002001-09-25T00:00:00Charybdotoxin49.824503311409127e-0021993-04-25T00:00:001998-08-01T00:00:00Cecum29.805077162270764e-0022010-01-28T00:00:002010-11-10T00:00:00gamma-Aminobutyric Acid19.783036093111186e-0022019-10-15T00:00:002019-10-15T00:00:00Disease Resistance19.772871749247496e-0022014-05-07T00:00:002014-05-07T00:00:00Embryo, Nonmammalian29.750840773600467e-0022005-05-24T00:00:002007-11-28T00:00:00Collagen Type I, alpha 1 Chain19.742847383387535e-0022013-02-13T00:00:002013-02-13T00:00:00Polymorphism, Restriction Fragment Length29.728382326045629e-0022010-10-01T00:00:002011-10-31T00:00:00Hypotension19.716387693727799e-0022019-03-13T00:00:002019-03-13T00:00:00RNA, Small Interfering59.691646452682715e-0022006-11-07T00:00:002019-09-26T00:00:00Protein Kinase Inhibitors39.687419131643102e-0022006-12-27T00:00:002021-05-03T00:00:00Cell Division79.672876231355704e-0021994-04-01T00:00:002004-07-19T00:00:00Early Growth Response Protein 129.671707580993473e-0021997-07-01T00:00:002012-01-07T00:00:00DNA-Binding Proteins49.552405775512622e-0021996-07-12T00:00:002025-05-13T00:00:00Cholestanols29.480638622925713e-0021998-01-01T00:00:002005-08-18T00:00:00Fluorescent Dyes29.404655147149973e-0021994-11-01T00:00:001998-01-01T00:00:00Minisatellite Repeats19.402866083388430e-0022013-02-10T00:00:002013-02-10T00:00:00Infarction, Middle Cerebral Artery19.389801159866182e-0022016-07-20T00:00:002016-07-20T00:00:00Retinol-Binding Proteins, Plasma19.378162153433450e-0022013-02-13T00:00:002013-02-13T00:00:00Germ-Line Mutation19.371719462412841e-0022021-07-14T00:00:002021-07-14T00:00:00Internal-External Control19.339185474757189e-0021994-02-01T00:00:001994-02-01T00:00:00Nerve Net19.278792203593360e-0022025-02-24T00:00:002025-02-24T00:00:00Drug Evaluation, Preclinical19.184599451202756e-0022017-04-29T00:00:002017-04-29T00:00:00Calpain19.178553257598086e-0022013-01-22T00:00:002013-01-22T00:00:00Blood Pressure39.156665669962819e-0022013-11-01T00:00:002024-08-23T00:00:00Gastrins19.106540200593313e-0022012-01-07T00:00:002012-01-07T00:00:00Precipitin Tests39.103799253856537e-0021993-10-01T00:00:001999-11-01T00:00:00Guanine Nucleotides19.099587821119320e-0022011-12-22T00:00:002011-12-22T00:00:00Genome-Wide Association Study29.073577790225440e-0022017-05-13T00:00:002024-11-25T00:00:00Heart Arrest, Induced29.058215767562157e-0021995-09-01T00:00:002008-09-30T00:00:00Altitude19.045430259102015e-0022013-03-22T00:00:002013-03-22T00:00:00Phorbol Esters19.002075765710464e-0022011-11-16T00:00:002011-11-16T00:00:00CHO Cells18.939299172902707e-0021994-09-01T00:00:001994-09-01T00:00:00Angiogenesis Inhibitors28.926924247449437e-0022001-05-01T00:00:002002-01-01T00:00:00Renal Dialysis28.902375726522710e-0022017-07-24T00:00:002021-02-17T00:00:00Radioisotopes28.867686360333850e-0022001-10-01T00:00:002005-08-01T00:00:00DNA58.855331077152268e-0021988-11-15T00:00:002000-07-24T00:00:00Proline28.813261788449218e-0022008-01-11T00:00:002017-07-10T00:00:00Blood Volume18.792216014705719e-0022013-03-22T00:00:002013-03-22T00:00:00Chloroquine18.789410018027737e-0022013-03-06T00:00:002013-03-06T00:00:00Up-Regulation58.787297577697838e-0022001-04-02T00:00:002016-01-01T00:00:00Receptors, IgG28.767715445748930e-0022002-02-28T00:00:002006-11-07T00:00:00Thapsigargin38.750845323408640e-0021997-06-01T00:00:002001-05-01T00:00:00Membrane Transport Modulators18.726033550249936e-0022011-05-18T00:00:002011-05-18T00:00:00Protein Kinase C-delta18.725275286452036e-0022011-11-16T00:00:002011-11-16T00:00:00Vasoconstrictor Agents48.708462143794615e-0022001-03-01T00:00:002016-11-01T00:00:00Temperature28.690733906040823e-0022013-03-06T00:00:002021-11-20T00:00:00Dipyridamole28.670917246949036e-0021997-08-01T00:00:002010-01-15T00:00:00Catalase18.667389435567210e-0022011-10-31T00:00:002011-10-31T00:00:00Nystatin18.629025095633974e-0022011-01-05T00:00:002011-01-05T00:00:00COS Cells48.628427414124806e-0022001-05-01T00:00:002009-10-01T00:00:00Neurons48.624497703259941e-0022004-11-17T00:00:002024-06-25T00:00:00Homeostasis68.612295669937858e-0021996-03-08T00:00:002022-12-01T00:00:00Urothelium18.589933333812957e-0022013-07-31T00:00:002013-07-31T00:00:00Cell Fusion28.581173910787976e-0022001-05-01T00:00:002002-07-01T00:00:00Learning Disabilities18.563436731568511e-0021994-02-01T00:00:001994-02-01T00:00:00Glycine28.535349982980532e-0021997-07-01T00:00:002013-10-01T00:00:00Calcium-Binding Proteins18.531000931139698e-0022016-01-01T00:00:002016-01-01T00:00:00Aorta28.453357208095741e-0021997-11-01T00:00:001997-12-01T00:00:00Carcinoma18.422283406695810e-0022002-05-01T00:00:002002-05-01T00:00:00Hair Cells, Auditory28.420264770277335e-0021997-12-01T00:00:002012-10-11T00:00:00Genetic Variation68.414972779066256e-0022004-11-17T00:00:002021-08-01T00:00:00Middle Aged278.370156774369013e-0021995-09-01T00:00:002025-05-02T00:00:00Chelating Agents28.345382993565575e-0022001-12-01T00:00:002003-01-15T00:00:00Behavior Therapy28.322923108141382e-0021994-02-01T00:00:001994-07-01T00:00:00Genetic Markers38.285998495600040e-0021998-03-13T00:00:002004-02-01T00:00:00Antigens18.256988417046833e-0021996-04-01T00:00:001996-04-01T00:00:00Protein Sorting Signals18.248313516335572e-0022011-07-20T00:00:002011-07-20T00:00:00Hypercalciuria18.198869590218803e-0022010-11-01T00:00:002010-11-01T00:00:00Anemia, Macrocytic18.198226579592548e-0022010-10-01T00:00:002010-10-01T00:00:00Gene Expression Regulation, Bacterial38.181794786323136e-0021994-04-22T00:00:002007-12-23T00:00:00Methylamines18.136344892398752e-0022011-08-17T00:00:002011-08-17T00:00:00Metabolism, Inborn Errors18.121855466246787e-0022012-11-24T00:00:002012-11-24T00:00:00Polymerase Chain Reaction88.089243054147188e-0021994-01-01T00:00:002012-01-07T00:00:00Norepinephrine18.047540874834637e-0022013-03-22T00:00:002013-03-22T00:00:00Chlorocebus aethiops48.012858551491003e-0022001-05-01T00:00:002009-10-01T00:00:00Signal Processing, Computer-Assisted17.988151528236735e-0021997-06-01T00:00:001997-06-01T00:00:00Isoproterenol27.959684903130788e-0021980-05-25T00:00:001980-11-25T00:00:00Dimerization27.872044793867658e-0021999-06-29T00:00:002003-08-21T00:00:00Community Mental Health Services17.864244401087737e-0021993-06-01T00:00:001993-06-01T00:00:00Fluorescent Antibody Technique, Indirect57.845398967259271e-0021997-05-01T00:00:002002-03-23T00:00:00Stress, Physiological27.815163306623403e-0021999-12-01T00:00:002016-10-21T00:00:00Tumor Cells, Cultured57.768778411264118e-0021997-05-15T00:00:002001-04-02T00:00:00Drug Delivery Systems17.763440913483614e-0022021-05-03T00:00:002021-05-03T00:00:00Pyrophosphatases27.745037017920203e-0021999-02-16T00:00:002001-09-25T00:00:00Isomerism37.716675065755814e-0021997-01-01T00:00:002004-01-28T00:00:00Sodium-Hydrogen Exchanger 337.646381026454868e-0022001-04-02T00:00:002024-01-15T00:00:00Statistics, Nonparametric27.619886843561949e-0022002-05-01T00:00:002007-07-01T00:00:00Proprotein Convertase 117.606839746601876e-0022009-02-25T00:00:002009-02-25T00:00:00Cell Membrane Permeability27.582199466729250e-0021997-12-15T00:00:002009-11-11T00:00:00Cohort Studies97.554736543359324e-0022004-02-01T00:00:002025-05-13T00:00:00DNA-Directed RNA Polymerases17.531504360537188e-0022011-11-16T00:00:002011-11-16T00:00:00Collagen Type I17.511832052878617e-0022013-02-13T00:00:002013-02-13T00:00:00Protein Interaction Mapping17.499836262522469e-0022013-04-01T00:00:002013-04-01T00:00:00Drug Repositioning27.458163160827611e-0022020-09-20T00:00:002023-04-12T00:00:00Ambystoma mexicanum17.371268048820212e-0022009-11-11T00:00:002009-11-11T00:00:00Microfilament Proteins17.361124552570864e-0021994-04-01T00:00:001994-04-01T00:00:00Suprachiasmatic Nucleus17.356934108618167e-0022009-11-22T00:00:002009-11-22T00:00:00Vitiligo17.332216694822526e-0022011-10-31T00:00:002011-10-31T00:00:00Osteoclasts17.326101097066293e-0022013-01-22T00:00:002013-01-22T00:00:00NF-kappa B17.262561988214618e-0022017-07-10T00:00:002017-07-10T00:00:00Spores, Bacterial57.253619636794687e-0021994-04-22T00:00:001996-06-01T00:00:00Open Reading Frames17.244123952292453e-0022012-03-09T00:00:002012-03-09T00:00:00Extracellular Space37.240379149046036e-0021997-01-01T00:00:002001-03-01T00:00:00Cell Death37.239885518598688e-0022015-12-23T00:00:002019-09-26T00:00:00Molecular Targeted Therapy17.233551837421209e-0022020-09-20T00:00:002020-09-20T00:00:00Cerebral Cortex17.224186843339923e-0022025-02-24T00:00:002025-02-24T00:00:00Immunoenzyme Techniques47.211246414007086e-0021997-10-01T00:00:002001-04-01T00:00:00Borohydrides17.205529758383759e-0022008-05-14T00:00:002008-05-14T00:00:00Cell Line, Transformed57.195642416572776e-0021993-10-01T00:00:002000-09-01T00:00:00DNA Primers67.177544665244337e-0021994-01-01T00:00:002007-05-17T00:00:00Immunity, Innate37.173266409393143e-0022009-04-22T00:00:002023-02-16T00:00:00JNK Mitogen-Activated Protein Kinases27.165229282776758e-0021998-12-01T00:00:002001-12-01T00:00:00Consanguinity17.151953816955015e-0022010-10-01T00:00:002010-10-01T00:00:00Heat-Shock Proteins37.134393055242153e-0021996-07-12T00:00:002016-10-21T00:00:00Antimalarials17.121235844235957e-0022015-10-12T00:00:002015-10-12T00:00:00Valinomycin17.120835900400592e-0022008-03-10T00:00:002008-03-10T00:00:00Black or African American47.088654784422790e-0022014-08-06T00:00:002018-03-12T00:00:00Chromatography, Gel17.086240791018368e-0022009-05-01T00:00:002009-05-01T00:00:00Adenosine27.037657626291158e-0022022-10-25T00:00:002024-01-31T00:00:00Tyrosine26.962027766758283e-0021998-12-01T00:00:002005-08-01T00:00:00Apoptosis26.951555385716839e-0021998-12-01T00:00:002007-01-24T00:00:00Biological Evolution16.946279269977122e-0022014-05-07T00:00:002014-05-07T00:00:00RNA26.934530177562498e-0021995-02-01T00:00:001997-06-01T00:00:00Nitrites26.932224038098267e-0021997-08-01T00:00:002006-11-01T00:00:00Insulin-Like Growth Factor I26.882891747263889e-0022004-07-19T00:00:002007-03-01T00:00:00Transformation, Bacterial16.873621902566125e-0022007-12-23T00:00:002007-12-23T00:00:00Mice, Inbred DBA56.864313522429076e-0021994-12-01T00:00:002001-10-01T00:00:00Cyst Fluid16.864252398809514e-0022008-09-01T00:00:002008-09-01T00:00:00Sulfonic Acids16.849464650839712e-0022008-05-14T00:00:002008-05-14T00:00:00Vasoconstriction26.817678386782092e-0021998-06-01T00:00:002009-05-03T00:00:00Carbonic Anhydrase Inhibitors26.806767850862183e-0022003-09-04T00:00:002010-01-28T00:00:00Sodium Bicarbonate26.727765855516615e-0022004-11-17T00:00:002004-12-01T00:00:00Histocompatibility Antigens Class I16.711655810673053e-0022014-07-21T00:00:002014-07-21T00:00:00Gout16.700927625550922e-0022015-03-04T00:00:002015-03-04T00:00:00Turkey26.694941713096922e-0022003-02-01T00:00:002011-10-31T00:00:00Swine46.642248120918778e-0021995-10-01T00:00:001999-06-29T00:00:00Inflammation46.627508845771775e-0022017-07-10T00:00:002023-08-01T00:00:00Caveolin 116.600725845907753e-0022009-04-22T00:00:002009-04-22T00:00:00Transcriptome26.546940910896766e-0022017-07-24T00:00:002025-05-05T00:00:00Genetic Therapy16.539399149275051e-0021999-08-01T00:00:001999-08-01T00:00:00Ryanodine16.458824666188275e-0022006-11-07T00:00:002006-11-07T00:00:00Proteome16.458669208365564e-0022017-12-04T00:00:002017-12-04T00:00:00Ubiquitin-Protein Ligases36.457206513728127e-0022001-04-02T00:00:002022-04-04T00:00:00Thiobarbituric Acid Reactive Substances16.437723411407485e-0022006-11-01T00:00:002006-11-01T00:00:00Lymphoid Tissue16.395621568168160e-0021988-11-15T00:00:001988-11-15T00:00:00Water46.392106395797403e-0022000-05-01T00:00:002015-10-12T00:00:00Rats, Inbred WKY26.390760405312532e-0021997-12-01T00:00:002016-01-01T00:00:00Mice, 129 Strain26.353359824677224e-0022015-06-11T00:00:002019-10-15T00:00:00Gene Frequency46.347913257314590e-0022009-06-09T00:00:002015-12-23T00:00:00Quality of Life16.314310134036157e-0022009-03-01T00:00:002009-03-01T00:00:00ADP Ribose Transferases16.312334951377256e-0022006-12-27T00:00:002006-12-27T00:00:00Saccharomyces cerevisiae26.274556102236881e-0021999-02-16T00:00:002013-04-01T00:00:00Cross-Over Studies36.258569436026638e-0022016-10-21T00:00:002017-12-04T00:00:00Diuretics26.253347451031273e-0022001-12-01T00:00:002017-07-10T00:00:00Subcellular Fractions36.232687825575811e-0021974-06-26T00:00:002005-05-24T00:00:00Respiration16.186515798321810e-0022013-03-22T00:00:002013-03-22T00:00:00Vestibular Diseases16.181959246210261e-0022009-10-01T00:00:002009-10-01T00:00:00Protons36.111810576635325e-0021994-09-01T00:00:002009-03-14T00:00:00Ultraviolet Therapy16.110493111555944e-0022006-11-01T00:00:002006-11-01T00:00:00Frameshift Mutation26.070009492548126e-0021997-01-01T00:00:002019-07-25T00:00:00Focal Adhesions16.066744233977054e-0022006-12-27T00:00:002006-12-27T00:00:00DNA Copy Number Variations16.063580085669766e-0022015-05-01T00:00:002015-05-01T00:00:00Small-Conductance Calcium-Activated Potassium Channels26.014314117078416e-0022001-03-19T00:00:002008-08-01T00:00:00Elliptocytosis, Hereditary15.985898078149261e-0022005-10-20T00:00:002005-10-20T00:00:00Anemia, Hemolytic15.977822326901931e-0022007-01-24T00:00:002007-01-24T00:00:00Genetic Vectors25.973005602484054e-0021994-04-01T00:00:002004-04-30T00:00:00Hypercapnia15.960972018966981e-0022007-07-25T00:00:002007-07-25T00:00:00Codon, Nonsense15.932290080172050e-0022007-08-09T00:00:002007-08-09T00:00:00Time Factors115.925381085453318e-0021977-01-01T00:00:002007-07-25T00:00:00Plasmodium falciparum15.885024608425046e-0022015-10-12T00:00:002015-10-12T00:00:00Cytosol55.849924665787666e-0021974-06-26T00:00:002016-10-14T00:00:00Cerebral Hemorrhage15.849872272371043e-0022017-07-10T00:00:002017-07-10T00:00:00Reference Values45.847355715288214e-0021995-02-01T00:00:002004-02-01T00:00:00GTPase-Activating Proteins25.816462167007430e-0022011-07-20T00:00:002023-11-17T00:00:00Cell Shape15.797515941534469e-0022006-12-27T00:00:002006-12-27T00:00:00Adolescent135.785037928698891e-0021977-01-01T00:00:002025-05-02T00:00:00Stroke25.776431030869587e-0022015-06-11T00:00:002020-01-07T00:00:00Aged185.774382014266152e-0021995-09-01T00:00:002025-05-05T00:00:00Microscopy, Electron55.772007356818702e-0021994-01-01T00:00:002004-04-30T00:00:00Drug Hypersensitivity15.740955857678407e-0021994-05-01T00:00:001994-05-01T00:00:00Sequence Analysis, DNA25.727313182906636e-0021997-10-02T00:00:002012-03-09T00:00:00Multiprotein Complexes15.663552463331151e-0022011-07-20T00:00:002011-07-20T00:00:00Erythroid Precursor Cells25.636679389775166e-0021998-08-21T00:00:002012-11-24T00:00:00Nitrates15.629843116013598e-0022006-11-01T00:00:002006-11-01T00:00:00Loop of Henle15.629730364539992e-0022004-12-01T00:00:002004-12-01T00:00:00Protein Phosphatase 115.627046685356381e-0022005-11-11T00:00:002005-11-11T00:00:00Chronic Kidney Diseases of Uncertain Etiology15.623590336578026e-0022024-11-25T00:00:002024-11-25T00:00:00Osmotic Pressure35.592479522364612e-0022000-05-01T00:00:002016-10-26T00:00:00Leptin15.561751638377363e-0022013-02-13T00:00:002013-02-13T00:00:00Central America15.542238738837391e-0022024-11-25T00:00:002024-11-25T00:00:00Endocytosis15.512092286757316e-0022009-04-22T00:00:002009-04-22T00:00:00Phylogeny15.502758081138384e-0022013-04-01T00:00:002013-04-01T00:00:00Katanin15.501006261361758e-0022024-06-25T00:00:002024-06-25T00:00:00Oligonucleotide Array Sequence Analysis15.495632770940914e-0022013-02-13T00:00:002013-02-13T00:00:00Receptors, Adiponectin15.494065727768756e-0022025-02-24T00:00:002025-02-24T00:00:00Recovery of Function15.479969414139552e-0022015-06-11T00:00:002015-06-11T00:00:00Syringomyelia15.476787499559169e-0022025-05-02T00:00:002025-05-02T00:00:00Thyroid Nuclear Factor 115.465716083768664e-0022025-02-24T00:00:002025-02-24T00:00:00Botulinum Toxins15.465165737624206e-0022006-12-27T00:00:002006-12-27T00:00:00Coat Protein Complex I15.454455807815375e-0022024-09-20T00:00:002024-09-20T00:00:00Phosphoprotein Phosphatases35.451912957185728e-0021995-10-27T00:00:002010-11-04T00:00:00Health15.442347507823903e-0022007-10-01T00:00:002007-10-01T00:00:00Electrophysiology45.385772000962275e-0021997-04-01T00:00:002004-09-03T00:00:00Biological Factors15.372790964993906e-0022005-08-18T00:00:002005-08-18T00:00:00Antigens, CD725.367860232651217e-0021993-10-01T00:00:001994-09-01T00:00:00Ependyma15.367465175568437e-0022024-06-25T00:00:002024-06-25T00:00:00Fluoresceins25.336277174051679e-0021994-09-01T00:00:001994-11-01T00:00:00Genes, Recessive25.332228562463645e-0021998-12-15T00:00:002015-05-01T00:00:00Intercellular Signaling Peptides and Proteins25.306102806624853e-0022000-05-01T00:00:002010-01-15T00:00:00Molecular Diagnostic Techniques15.305966226686060e-0022009-10-01T00:00:002009-10-01T00:00:00Kidney Neoplasms15.271163745135754e-0022021-07-14T00:00:002021-07-14T00:00:00Endostatins25.253707648815847e-0022001-05-01T00:00:002002-01-01T00:00:00Image Interpretation, Computer-Assisted15.248849234758750e-0021997-06-01T00:00:001997-06-01T00:00:00ATPases Associated with Diverse Cellular Activities15.239501840781324e-0022024-06-25T00:00:002024-06-25T00:00:00Amides15.228008422586825e-0022006-12-27T00:00:002006-12-27T00:00:00Nelfinavir15.208403012376316e-0022003-12-30T00:00:002003-12-30T00:00:00Substrate Specificity15.195761601181034e-0022007-12-23T00:00:002007-12-23T00:00:00Central Nervous System25.172355963742212e-0022003-03-28T00:00:002019-10-15T00:00:00p120 GTPase Activating Protein15.171322054095822e-0022023-11-17T00:00:002023-11-17T00:00:00Charcot-Marie-Tooth Disease15.148543425034511e-0022024-11-13T00:00:002024-11-13T00:00:00Bile Ducts, Intrahepatic25.111990234075947e-0021997-05-01T00:00:002003-03-26T00:00:00Telomerase15.107791842043660e-0022009-02-25T00:00:002009-02-25T00:00:00Cholinergic Agents15.072699642963036e-0022024-01-31T00:00:002024-01-31T00:00:00Foramen Magnum15.047549476596910e-0022023-10-04T00:00:002023-10-04T00:00:00Mice, Inbred CFTR15.035768730363257e-0022003-03-21T00:00:002003-03-21T00:00:00Persons with Disabilities15.025090221322084e-0021993-06-01T00:00:001993-06-01T00:00:00Blastocyst25.014365315908922e-0021995-10-13T00:00:001997-09-01T00:00:00Molecular Biology15.007391017114769e-0021987-03-01T00:00:001987-03-01T00:00:00India14.998505013554387e-0022010-10-01T00:00:002010-10-01T00:00:00Human Genetics14.979274372312548e-0022023-10-04T00:00:002023-10-04T00:00:00Brain Injuries14.977772856398429e-0022015-06-11T00:00:002015-06-11T00:00:00Computer Simulation24.964808918907256e-0022010-12-29T00:00:002021-08-01T00:00:00Epithelium44.955752434842269e-0021987-12-01T00:00:002004-04-30T00:00:00Calmodulin24.953805177174470e-0021980-11-25T00:00:002001-03-19T00:00:00Blood-Brain Barrier24.947330020693635e-0022016-10-26T00:00:002023-02-16T00:00:00Antibody Specificity24.942777798857458e-0021989-07-01T00:00:001999-11-01T00:00:00Cross-Sectional Studies54.911713227053705e-0022009-03-01T00:00:002024-12-03T00:00:00Receptors, Muscarinic14.910137340120910e-0022003-09-04T00:00:002003-09-04T00:00:00Secretin14.901612594216313e-0022003-03-26T00:00:002003-03-26T00:00:00Tubulin14.885201235400712e-0022006-11-07T00:00:002006-11-07T00:00:00Genetic Testing34.850158188726113e-0022004-02-01T00:00:002023-03-06T00:00:00Activin Receptors, Type II14.849702204643250e-0022023-11-17T00:00:002023-11-17T00:00:00Delivery of Health Care14.834155710255746e-0022021-02-17T00:00:002021-02-17T00:00:00Cell Proliferation44.798773948463591e-0022007-03-01T00:00:002020-08-28T00:00:00Brain Ischemia14.769547989155776e-0022016-01-01T00:00:002016-01-01T00:00:00Microscopy, Immunoelectron24.761846137154133e-0021998-06-01T00:00:002004-01-28T00:00:00Receptor, Endothelin B14.753801656273523e-0022022-12-01T00:00:002022-12-01T00:00:00Golgi Apparatus14.738825267529198e-0022024-09-20T00:00:002024-09-20T00:00:00Keratosis, Seborrheic14.728716607476725e-0022002-10-01T00:00:002002-10-01T00:00:00Alendronate14.728340630851888e-0022003-12-30T00:00:002003-12-30T00:00:00Asian People14.717231818664504e-0022009-06-09T00:00:002009-06-09T00:00:00K562 Cells24.699865809381766e-0022012-11-24T00:00:002015-10-01T00:00:00Spectrometry, Fluorescence14.680443640868249e-0022004-11-17T00:00:002004-11-17T00:00:00Enterocytes14.662228358627969e-0022024-01-15T00:00:002024-01-15T00:00:00Electrodes14.656227364118238e-0022004-11-17T00:00:002004-11-17T00:00:00Imidazoline Receptors24.650111336298637e-0021995-07-12T00:00:002019-07-25T00:00:00Diacylglycerol O-Acyltransferase14.619904353535788e-0022022-03-01T00:00:002022-03-01T00:00:00Glutamic Acid14.615729213563501e-0022008-05-14T00:00:002008-05-14T00:00:00Globins24.612563186493330e-0021980-11-25T00:00:001996-02-01T00:00:00Interferon-Induced Helicase, IFIH114.606253557433930e-0022022-10-25T00:00:002022-10-25T00:00:00Sodium Radioisotopes14.605385801130276e-0022001-12-01T00:00:002001-12-01T00:00:00Receptors, Mineralocorticoid14.587416323686221e-0022023-08-01T00:00:002023-08-01T00:00:00Tumor Necrosis Factor-alpha14.585889016051067e-0022013-07-31T00:00:002013-07-31T00:00:00Lysine24.580877130576572e-0021999-06-29T00:00:002014-05-07T00:00:00Aspartic Acid Endopeptidases14.555856777680590e-0022003-12-30T00:00:002003-12-30T00:00:00Biophysics14.538396718767653e-0022003-07-01T00:00:002003-07-01T00:00:00Salivary Glands14.537758135809513e-0022003-09-04T00:00:002003-09-04T00:00:00Inosine14.520223717807675e-0022022-10-25T00:00:002022-10-25T00:00:00Cations, Divalent14.515947643053965e-0022002-02-28T00:00:002002-02-28T00:00:00Proton Pumps14.502595751510155e-0022001-09-25T00:00:002001-09-25T00:00:00Anthracenes14.501823094602823e-0022001-12-01T00:00:002001-12-01T00:00:00Databases, Factual14.501028158473763e-0022017-11-23T00:00:002017-11-23T00:00:00Cochlea24.474284780728466e-0021997-12-01T00:00:001998-11-11T00:00:00Tuberculosis, Multidrug-Resistant14.455278075328549e-0022010-10-01T00:00:002010-10-01T00:00:00Cell Fractionation14.450668434654970e-0022002-03-23T00:00:002002-03-23T00:00:00Pyramidal Cells14.437275819792307e-0022024-06-25T00:00:002024-06-25T00:00:00Estrenes14.410070165765993e-0022001-05-01T00:00:002001-05-01T00:00:00Nobel Prize14.397275413637352e-0022021-11-20T00:00:002021-11-20T00:00:00DNA Breaks14.391977401680671e-0022021-07-14T00:00:002021-07-14T00:00:00Lipid Bilayers14.384025467954647e-0022003-08-21T00:00:002003-08-21T00:00:00White People24.375480805968857e-0022009-06-09T00:00:002021-08-01T00:00:00Membranes24.372344963659323e-0021996-08-01T00:00:002004-01-28T00:00:00Angiostatins14.362176383255922e-0022001-05-01T00:00:002001-05-01T00:00:00RNA Editing14.355535139252704e-0022022-10-25T00:00:002022-10-25T00:00:00Brain Chemistry24.354681502194077e-0021999-12-01T00:00:002007-07-25T00:00:00Virulence Factors, Bordetella14.343863861391518e-0022001-05-01T00:00:002001-05-01T00:00:00Ligands24.343388960326975e-0021994-04-01T00:00:002002-02-28T00:00:00Proteomics34.337778783971878e-0022016-10-26T00:00:002021-08-25T00:00:00Helix-Loop-Helix Motifs14.325075448798298e-0022001-05-01T00:00:002001-05-01T00:00:00Spectrin34.318745629297881e-0021980-11-25T00:00:001996-09-20T00:00:00Myocytes, Cardiac14.317580915040029e-0022010-11-04T00:00:002010-11-04T00:00:00Pertussis Toxin14.317286076105747e-0022001-05-01T00:00:002001-05-01T00:00:00Polyglutamic Acid14.315350732482620e-0022001-03-19T00:00:002001-03-19T00:00:00Proteinuria14.313058658471815e-0022024-08-23T00:00:002024-08-23T00:00:00Tetraethylammonium24.311865077593029e-0021997-07-01T00:00:001999-02-01T00:00:00Gene Expression Regulation, Enzymologic14.310948517288882e-0022005-11-11T00:00:002005-11-11T00:00:00Uterine Cervical Neoplasms24.297869497926597e-0022003-08-04T00:00:002004-07-19T00:00:00Colonic Neoplasms24.285980110448125e-0021998-08-01T00:00:002012-01-07T00:00:00Tilapia14.277422787073948e-0022001-02-01T00:00:002001-02-01T00:00:00Pandemics14.271740295847284e-0022021-02-17T00:00:002021-02-17T00:00:00Gills14.253504442986333e-0022001-02-01T00:00:002001-02-01T00:00:00Inositol 1,4,5-Trisphosphate Receptors14.238773613926537e-0022001-05-01T00:00:002001-05-01T00:00:00Macrocyclic Compounds14.236876673545277e-0022001-05-01T00:00:002001-05-01T00:00:00Serous Membrane14.233351779029355e-0022000-10-01T00:00:002000-10-01T00:00:00Repetitive Sequences, Amino Acid14.231535761747746e-0022001-03-19T00:00:002001-03-19T00:00:00Pseudomonas aeruginosa14.224085302696329e-0022009-04-22T00:00:002009-04-22T00:00:00Glucose34.204144495372260e-0021999-08-01T00:00:002020-06-15T00:00:00Cardiomyopathy, Hypertrophic14.198538817252290e-0022010-11-04T00:00:002010-11-04T00:00:00Alkaline Phosphatase14.196529605401717e-0022024-01-31T00:00:002024-01-31T00:00:00Cryoultramicrotomy24.195069892798586e-0021996-04-01T00:00:002001-04-01T00:00:00Hydrogen14.192917829476046e-0022001-12-01T00:00:002001-12-01T00:00:00Plasma Membrane Calcium-Transporting ATPases24.181912214520055e-0021997-06-01T00:00:002017-05-13T00:00:00Calcium Channel Blockers24.180728444048156e-0021996-02-01T00:00:002002-02-28T00:00:00Pyrrolidinones14.171874822403816e-0022001-05-01T00:00:002001-05-01T00:00:00RNA, Double-Stranded14.160012591080399e-0022022-10-25T00:00:002022-10-25T00:00:00Butyrates14.154402696439202e-0022001-10-01T00:00:002001-10-01T00:00:00Acute Kidney Injury14.150312344056027e-0022013-07-31T00:00:002013-07-31T00:00:00Genetic Linkage24.145346667612346e-0021998-03-13T00:00:002013-02-10T00:00:00Neck14.133049059944845e-0022005-08-01T00:00:002005-08-01T00:00:00Intracellular Signaling Peptides and Proteins24.132376399343203e-0022016-10-14T00:00:002024-04-04T00:00:00Short Interspersed Nucleotide Elements14.129621278699768e-0022000-07-24T00:00:002000-07-24T00:00:00Eye Proteins14.124335405900350e-0022024-04-04T00:00:002024-04-04T00:00:00Dasatinib14.121689943237392e-0022021-05-03T00:00:002021-05-03T00:00:00Carbon Radioisotopes24.118199657277550e-0021974-06-26T00:00:002001-10-01T00:00:00Solutions24.110837095590393e-0021997-03-01T00:00:002001-09-25T00:00:00Type C Phospholipases14.110126353160615e-0022001-05-01T00:00:002001-05-01T00:00:00Gene Knockdown Techniques24.105064451230255e-0022012-07-16T00:00:002017-07-10T00:00:00Phosphatidylcholine-Sterol O-Acyltransferase14.092676339910305e-0022000-07-24T00:00:002000-07-24T00:00:00Tinea14.086948396274667e-0022000-05-01T00:00:002000-05-01T00:00:00Critical Illness14.075109609411583e-0022013-11-01T00:00:002013-11-01T00:00:00Mitochondrial Proton-Translocating ATPases14.069221471070387e-0022000-09-01T00:00:002000-09-01T00:00:00Cytokine Release Syndrome14.068122664194198e-0022023-02-16T00:00:002023-02-16T00:00:00Microelectrodes14.051171399224878e-0022001-10-01T00:00:002001-10-01T00:00:00Ileum14.045590305534710e-0022003-03-21T00:00:002003-03-21T00:00:00Protease Inhibitors14.041493164983003e-0022003-12-30T00:00:002003-12-30T00:00:00Microbial Sensitivity Tests14.029586653889961e-0022007-07-01T00:00:002007-07-01T00:00:00Peptidomimetics14.021679147016602e-0022020-06-15T00:00:002020-06-15T00:00:00Zinc Fingers13.990109634134795e-0022002-07-01T00:00:002002-07-01T00:00:00Cystitis13.983815414226977e-0022020-08-28T00:00:002020-08-28T00:00:00Stilbenes23.979605325220349e-0021997-03-01T00:00:002000-10-01T00:00:00Bacteria13.973123496503340e-0022011-11-16T00:00:002011-11-16T00:00:00Disorders of Sex Development13.968264669927710e-0022001-05-01T00:00:002001-05-01T00:00:00Vasodilator Agents23.950551072837804e-0021998-06-01T00:00:002008-09-30T00:00:00Pigmentation13.942057284554127e-0022000-09-01T00:00:002000-09-01T00:00:00Cryoelectron Microscopy13.941520453662652e-0022024-09-20T00:00:002024-09-20T00:00:00Syndrome23.912758429379142e-0022001-03-01T00:00:002009-04-01T00:00:00Embryo, Mammalian23.912169185882401e-0021997-12-01T00:00:002013-03-11T00:00:00Mitochondrial Permeability Transition Pore13.911446361520560e-0022019-09-26T00:00:002019-09-26T00:00:00Aquaporins23.911263309475112e-0021995-12-01T00:00:002003-03-26T00:00:00Drug Design13.901339606470415e-0022025-04-28T00:00:002025-04-28T00:00:00Ciliary Body13.895992693122709e-0022000-09-01T00:00:002000-09-01T00:00:00Urea23.894941434490398e-0021998-12-01T00:00:002001-02-01T00:00:00Clopidogrel13.891810405272108e-0022023-04-12T00:00:002023-04-12T00:00:00Genetic Association Studies23.878962623521963e-0022016-05-05T00:00:002021-07-14T00:00:00Ligases13.874995615755512e-0022001-04-02T00:00:002001-04-02T00:00:00Mice, Inbred CBA13.871863100625515e-0022000-07-24T00:00:002000-07-24T00:00:00Activating Transcription Factor 613.843143214127023e-0022019-07-25T00:00:002019-07-25T00:00:00Oxazoles13.834671625941694e-0022001-05-01T00:00:002001-05-01T00:00:00Cystic Fibrosis13.796291632409988e-0022009-04-22T00:00:002009-04-22T00:00:00Protein Kinases23.786829149426631e-0021980-11-25T00:00:002009-11-22T00:00:00Pemphigus13.780257281030854e-0022000-05-01T00:00:002000-05-01T00:00:00Epidermis13.771224797163700e-0022002-07-01T00:00:002002-07-01T00:00:00Gingival Hypertrophy13.769609367651824e-0021999-01-01T00:00:001999-01-01T00:00:00Lipoid Proteinosis of Urbach and Wiethe13.768846360690439e-0021999-01-01T00:00:001999-01-01T00:00:00Oligonucleotide Probes13.764546974994419e-0021999-11-01T00:00:001999-11-01T00:00:00Sequence Homology, Nucleic Acid13.761143111846389e-0022000-07-24T00:00:002000-07-24T00:00:00Hydrostatic Pressure13.748717646211146e-0021999-08-01T00:00:001999-08-01T00:00:00Islets of Langerhans13.739156834601956e-0022004-11-17T00:00:002004-11-17T00:00:00Macroglossia13.736370441408581e-0021999-01-01T00:00:001999-01-01T00:00:00Paracrine Communication13.733950530150851e-0022001-03-01T00:00:002001-03-01T00:00:00Skull13.722551842766500e-0022023-10-27T00:00:002023-10-27T00:00:00Cell Cycle23.716772174437724e-0021997-05-01T00:00:001997-06-01T00:00:00Ephrins13.682055612851275e-0022018-12-18T00:00:002018-12-18T00:00:00Sepsis13.678219188710048e-0022013-07-31T00:00:002013-07-31T00:00:00Sarcoma, Kaposi13.675351276163465e-0022002-05-01T00:00:002002-05-01T00:00:00Aquaporin 413.674662952152483e-0022020-01-18T00:00:002020-01-18T00:00:00Cell Respiration13.672163917759968e-0022019-09-26T00:00:002019-09-26T00:00:00Antigens, Neoplasm13.663739269199758e-0022007-07-25T00:00:002007-07-25T00:00:00Potassium Channels, Voltage-Gated13.662823956258801e-0021999-12-01T00:00:001999-12-01T00:00:00Black People23.660423154656315e-0022015-12-23T00:00:002019-02-07T00:00:00Face13.657439078037279e-0022005-08-01T00:00:002005-08-01T00:00:00Large-Conductance Calcium-Activated Potassium Channels23.657206599975150e-0022008-08-01T00:00:002009-05-03T00:00:00Friend murine leukemia virus13.656079548543717e-0021998-08-21T00:00:001998-08-21T00:00:00Cathepsins13.655478409805746e-0022020-01-10T00:00:002020-01-10T00:00:00Calcium Channels, L-Type13.628496864134113e-0022020-08-28T00:00:002020-08-28T00:00:00Monosaccharide Transport Proteins23.623252533886529e-0021989-04-01T00:00:001991-11-01T00:00:00Young Adult53.622786486320934e-0022013-02-14T00:00:002025-05-02T00:00:00Tandem Repeat Sequences13.620244091803553e-0022000-01-01T00:00:002000-01-01T00:00:00Kidney Tubules, Distal13.615141564887553e-0021998-09-01T00:00:001998-09-01T00:00:00Receptor, EphB413.615140344284428e-0022018-12-18T00:00:002018-12-18T00:00:00Chromosomes, Human, Pair 1113.602244224725477e-0022000-01-01T00:00:002000-01-01T00:00:00Cytoskeleton43.597454095555173e-0021994-04-01T00:00:001999-02-01T00:00:00Anti-Bacterial Agents13.595548154778983e-0021998-01-01T00:00:001998-01-01T00:00:00Coronary Vessels23.595271261595781e-0021995-09-01T00:00:002008-09-30T00:00:00Psoriasis13.590603433965523e-0022006-11-01T00:00:002006-11-01T00:00:00Prognosis53.588822557040704e-0022007-03-01T00:00:002021-06-07T00:00:00Administration, Oral53.588351405811768e-0021994-04-01T00:00:002004-12-01T00:00:00Drugs, Investigational13.587067608311867e-0022020-09-20T00:00:002020-09-20T00:00:00Lithium13.577889221087688e-0022021-08-25T00:00:002021-08-25T00:00:00Chromatography, Affinity23.556210079396334e-0021996-07-12T00:00:001996-07-12T00:00:00Pyrimidines23.554080175305877e-0022001-05-01T00:00:002021-05-03T00:00:00Vocational Guidance13.550942416652976e-0021978-04-01T00:00:001978-04-01T00:00:00Propranolol13.549657669437364e-0021980-05-25T00:00:001980-05-25T00:00:00Enzyme Induction13.525218247414639e-0021999-01-08T00:00:001999-01-08T00:00:00Hematology13.495210506180269e-0022021-11-20T00:00:002021-11-20T00:00:00Patched-1 Receptor13.492725265367327e-0022018-07-05T00:00:002018-07-05T00:00:00Work Capacity Evaluation13.488252495924978e-0021978-04-01T00:00:001978-04-01T00:00:00Immunosuppressive Agents23.442370387404103e-0022000-05-01T00:00:002002-05-01T00:00:00Mitosis13.415139078853702e-0022003-05-01T00:00:002003-05-01T00:00:00Crystallization13.409766033286867e-0021999-01-01T00:00:001999-01-01T00:00:00N-Acetylglucosaminyltransferases13.407688951843046e-0022019-07-02T00:00:002019-07-02T00:00:00Repetitive Sequences, Nucleic Acid13.394391464673462e-0022000-01-01T00:00:002000-01-01T00:00:00Salicylanilides13.393246808655825e-0022017-07-10T00:00:002017-07-10T00:00:00Alzheimer Disease13.387845505479852e-0022020-01-18T00:00:002020-01-18T00:00:00Tetraethylammonium Compounds13.382055292443698e-0021997-07-01T00:00:001997-07-01T00:00:00Thiocarbamates13.379735301514548e-0022017-07-10T00:00:002017-07-10T00:00:00Activities of Daily Living23.370057286028341e-0021993-06-01T00:00:002000-04-01T00:00:00Angiotensin II13.368098647697507e-0022001-03-01T00:00:002001-03-01T00:00:00Epididymis13.367372780852007e-0021999-10-01T00:00:001999-10-01T00:00:00Cross Reactions13.348954899680826e-0021999-11-01T00:00:001999-11-01T00:00:00Chronic Disease33.342558910776384e-0022003-03-28T00:00:002007-07-25T00:00:00Turkeys43.342473716710638e-0021979-10-01T00:00:001980-12-01T00:00:00Organoids13.339663842810543e-0022024-11-13T00:00:002024-11-13T00:00:00Sodium Acetate13.339089358922504e-0021997-04-01T00:00:001997-04-01T00:00:00X-Ray Film13.336719365132967e-0021997-06-01T00:00:001997-06-01T00:00:00Phosphorus Radioisotopes13.332854697673275e-0021997-06-01T00:00:001997-06-01T00:00:00Pyrrolidonecarboxylic Acid13.331908670106373e-0021997-10-01T00:00:001997-10-01T00:00:00Basal Cell Carcinoma13.323948881668978e-0022003-02-01T00:00:002003-02-01T00:00:00Vasodilation33.323630703006077e-0021998-06-01T00:00:002008-09-30T00:00:00Superior Cervical Ganglion13.322330297516048e-0021997-05-15T00:00:001997-05-15T00:00:00Cell Line, Tumor53.295675783175357e-0022003-08-04T00:00:002021-07-14T00:00:00Barbiturates13.285869940198845e-0021998-01-01T00:00:001998-01-01T00:00:00Sulfur Radioisotopes13.285792115352795e-0021997-03-01T00:00:001997-03-01T00:00:00Calcium-Calmodulin-Dependent Protein Kinases13.285063055191019e-0021998-12-01T00:00:001998-12-01T00:00:00Calcium-Transporting ATPases13.277935920862189e-0021997-06-01T00:00:001997-06-01T00:00:00Ectoderm13.272786970971407e-0021997-09-01T00:00:001997-09-01T00:00:00Injections, Subcutaneous13.271516056821982e-0022019-03-13T00:00:002019-03-13T00:00:00Mitochondria23.266935306218489e-0022016-10-14T00:00:002024-11-13T00:00:00Camping13.261955209415369e-0021977-01-01T00:00:001977-01-01T00:00:00Toxins, Biological13.255826463620944e-0021997-07-01T00:00:001997-07-01T00:00:00Mineralocorticoid Receptor Antagonists13.254491894537619e-0022023-08-01T00:00:002023-08-01T00:00:00HL-60 Cells13.252634938655036e-0021998-01-01T00:00:001998-01-01T00:00:00Carcinoma, Squamous Cell23.252386706901871e-0022002-10-01T00:00:002003-02-01T00:00:00Size Perception13.251599054378801e-0021977-03-01T00:00:001977-03-01T00:00:00Gastric Fundus13.247784044424054e-0021997-03-15T00:00:001997-03-15T00:00:00Microtomy13.243832246502326e-0021997-01-01T00:00:001997-01-01T00:00:00Unfolded Protein Response13.233337734654803e-0022019-07-25T00:00:002019-07-25T00:00:00Healthy Volunteers13.212774613810376e-0022021-06-07T00:00:002021-06-07T00:00:00Multivesicular Bodies13.210110210498037e-0022016-10-14T00:00:002016-10-14T00:00:00Inhibitory Concentration 5013.202931455262687e-0021998-01-01T00:00:001998-01-01T00:00:00Oxidants13.200542721251654e-0021997-08-01T00:00:001997-08-01T00:00:00PC12 Cells13.197212585847389e-0021997-05-15T00:00:001997-05-15T00:00:00Sodium, Dietary13.196699550520753e-0022000-11-01T00:00:002000-11-01T00:00:00Metalloendopeptidases13.195180484738009e-0022018-12-18T00:00:002018-12-18T00:00:00Autophagy-Related Protein 713.193607125593746e-0022016-10-14T00:00:002016-10-14T00:00:00Respiratory Mucosa13.187220944485250e-0022000-10-01T00:00:002000-10-01T00:00:00Sequence Deletion23.180947938269117e-0021996-03-08T00:00:002003-08-04T00:00:00Oximes23.180792696949653e-0022008-08-01T00:00:002008-09-30T00:00:00Receptors, Cytoplasmic and Nuclear13.170150028147846e-0022001-05-01T00:00:002001-05-01T00:00:00Age of Onset23.168786914964268e-0021999-01-01T00:00:002021-08-01T00:00:00Injections, Intravenous13.163098859991247e-0022019-03-13T00:00:002019-03-13T00:00:00Ferrets13.162618554295040e-0021997-07-01T00:00:001997-07-01T00:00:00Microinjections13.158562598212033e-0021997-10-02T00:00:001997-10-02T00:00:00Blotting, Southern13.147931705095646e-0021997-06-01T00:00:001997-06-01T00:00:00Autophagy-Related Protein-1 Homolog13.137068822096998e-0022016-10-14T00:00:002016-10-14T00:00:00Penetrance13.135349135143424e-0022018-12-18T00:00:002018-12-18T00:00:00Body Patterning13.135146095034404e-0022001-05-01T00:00:002001-05-01T00:00:00Genes, Tumor Suppressor13.133354624677793e-0022001-04-02T00:00:002001-04-02T00:00:00Arabidopsis Proteins13.127438223545483e-0021999-02-16T00:00:001999-02-16T00:00:00Chymotrypsin13.126859316418292e-0021996-08-13T00:00:001996-08-13T00:00:00Aged, 80 and over53.124156559877121e-0022002-05-01T00:00:002025-05-05T00:00:00Glyburide13.119144111307215e-0021997-07-01T00:00:001997-07-01T00:00:00Biopsy13.116107228170369e-0022008-08-27T00:00:002008-08-27T00:00:00Nitric Oxide Synthase Type III13.111454146973883e-0021999-08-01T00:00:001999-08-01T00:00:00Electrophoresis, Gel, Two-Dimensional13.106335995310427e-0022016-10-21T00:00:002016-10-21T00:00:00Photography13.101612907215381e-0022000-04-01T00:00:002000-04-01T00:00:00Dose-Response Relationship, Drug43.092218489880893e-0021996-01-04T00:00:002008-08-01T00:00:00Succinimides13.091619703730374e-0021996-07-12T00:00:001996-07-12T00:00:00Dinoprost13.088122242155815e-0022016-11-01T00:00:002016-11-01T00:00:00Chromosomes, Human, Pair 1713.078322048311979e-0021998-03-13T00:00:001998-03-13T00:00:00Monosaccharides13.075730989128454e-0021996-08-01T00:00:001996-08-01T00:00:00Proto-Oncogenes13.072413341269530e-0021997-05-01T00:00:001997-05-01T00:00:00DNA Fragmentation13.069547521060602e-0021997-01-01T00:00:001997-01-01T00:00:00Erythrocyte Aging13.067220927825088e-0021996-02-01T00:00:001996-02-01T00:00:00Homocysteine13.054199844691398e-0021999-08-01T00:00:001999-08-01T00:00:00Incidence33.053952957070469e-0022004-02-01T00:00:002018-07-02T00:00:00Doxorubicin13.053874240820372e-0022023-04-12T00:00:002023-04-12T00:00:001-Methyl-3-isobutylxanthine23.041810310729259e-0021980-05-25T00:00:002010-01-28T00:00:00Adenosine Triphosphatases13.020572846138286e-0022000-09-01T00:00:002000-09-01T00:00:00RNA, Guide, CRISPR-Cas Systems13.005518868998300e-0022019-07-02T00:00:002019-07-02T00:00:00Mammals12.992460642649749e-0022021-10-05T00:00:002021-10-05T00:00:00Benzoquinones12.988217883009908e-0022016-10-14T00:00:002016-10-14T00:00:00Cytokine Receptor gp13012.981695417042219e-0022015-12-23T00:00:002015-12-23T00:00:00Colchicine12.969978454843251e-0021997-10-01T00:00:001997-10-01T00:00:00Piperidines12.963600060973098e-0022025-02-24T00:00:002025-02-24T00:00:00Rats, Inbred SHR12.959126443655758e-0022016-01-01T00:00:002016-01-01T00:00:00Chromatography, High Pressure Liquid22.955523968539988e-0022009-06-09T00:00:002009-10-01T00:00:00Antisickling Agents12.936019840252635e-0021996-03-01T00:00:001996-03-01T00:00:00Vestibule, Labyrinth12.927069447887541e-0021997-12-01T00:00:001997-12-01T00:00:00Endosomes12.914423361055814e-0022019-02-07T00:00:002019-02-07T00:00:00Microsomes12.912386547000364e-0021995-11-01T00:00:001995-11-01T00:00:00Adrenergic alpha-Antagonists12.906014381717318e-0021996-01-04T00:00:001996-01-04T00:00:00Leukotriene B412.904615801414502e-0022016-11-01T00:00:002016-11-01T00:00:00Arteriosclerosis12.892372339138791e-0021999-12-01T00:00:001999-12-01T00:00:00Monocytes12.891246797478531e-0022025-05-05T00:00:002025-05-05T00:00:00Volunteers12.877866649692290e-0021977-01-01T00:00:001977-01-01T00:00:00Microsatellite Repeats12.871115656066215e-0021998-03-13T00:00:001998-03-13T00:00:00Hydrolysis12.866639170201087e-0021996-08-13T00:00:001996-08-13T00:00:00Stomach12.865701698327831e-0022000-01-01T00:00:002000-01-01T00:00:00Association Learning12.863872740691783e-0021977-03-01T00:00:001977-03-01T00:00:00Rats, Inbred Strains32.863499028724790e-0021989-05-15T00:00:001996-05-01T00:00:00Receptors, Drug12.854721681086604e-0021995-07-12T00:00:001995-07-12T00:00:00Lab-On-A-Chip Devices12.842810356994911e-0022020-06-15T00:00:002020-06-15T00:00:00Cardioplegic Solutions12.840962800631467e-0021995-09-01T00:00:001995-09-01T00:00:00Nitric Oxide22.833758711365215e-0022006-11-01T00:00:002019-03-13T00:00:00Liver32.827434226343248e-0021974-06-26T00:00:002014-07-21T00:00:00Benzofurans12.822363771766100e-0021996-01-04T00:00:001996-01-04T00:00:00Molecular Conformation12.821345890407068e-0021996-08-01T00:00:001996-08-01T00:00:00Organelles12.820415424167331e-0021997-04-01T00:00:001997-04-01T00:00:00Ethnicity12.808090443141977e-0022010-10-01T00:00:002010-10-01T00:00:00Receptors, N-Methyl-D-Aspartate12.806158588097261e-0022020-08-28T00:00:002020-08-28T00:00:00Nephrectomy12.804640085528611e-0022020-06-15T00:00:002020-06-15T00:00:00Cell Adhesion Molecules12.797120828076779e-0022021-08-01T00:00:002021-08-01T00:00:00Diagnosis, Differential22.791362229708137e-0021999-01-01T00:00:002008-08-27T00:00:00Immunoprecipitation12.789365330894854e-0022017-07-10T00:00:002017-07-10T00:00:00Audiometry, Pure-Tone12.786978492718890e-0022015-10-20T00:00:002015-10-20T00:00:00Gastrointestinal Diseases12.782761059842144e-0022003-12-30T00:00:002003-12-30T00:00:00Lactams, Macrocyclic12.779221174171697e-0022016-10-14T00:00:002016-10-14T00:00:00Heart Atria12.777337064532839e-0022001-03-01T00:00:002001-03-01T00:00:00Histamine12.776837292203687e-0022016-11-01T00:00:002016-11-01T00:00:00Molecular Motor Proteins12.776370583552833e-0022015-05-01T00:00:002015-05-01T00:00:00Arginine22.770939220619433e-0021995-02-01T00:00:001997-08-01T00:00:00Urinary Tract12.766456363546137e-0021998-06-01T00:00:001998-06-01T00:00:00Genomics22.764750305027941e-0022021-07-07T00:00:002021-07-14T00:00:00Biopolymers12.763470607446685e-0021995-11-01T00:00:001995-11-01T00:00:00Proto-Oncogene Proteins c-fos12.762953258133001e-0021997-07-01T00:00:001997-07-01T00:00:00Hemoglobins22.759283591732676e-0021994-01-01T00:00:001998-12-15T00:00:00Cytochrome P-450 Enzyme System12.757757035437094e-0021997-07-01T00:00:001997-07-01T00:00:00Calibration12.740246984460115e-0021997-06-01T00:00:001997-06-01T00:00:00UGT1A1 Enzyme12.739583270200572e-0022014-07-21T00:00:002014-07-21T00:00:00Immediate-Early Proteins12.733454052284650e-0021997-07-01T00:00:001997-07-01T00:00:00Mandrillus12.732806309412452e-0022014-05-07T00:00:002014-05-07T00:00:00Body Water22.729007508929195e-0021991-11-01T00:00:001996-02-01T00:00:00Hydroxyurea12.727695082612007e-0021996-02-01T00:00:001996-02-01T00:00:00Anti-Arrhythmia Agents22.726289422649742e-0021994-10-01T00:00:002000-05-01T00:00:00Human Genome Project12.723000832579084e-0022015-05-01T00:00:002015-05-01T00:00:00Pyridines12.713638456220644e-0022006-12-27T00:00:002006-12-27T00:00:00Basic Helix-Loop-Helix Proteins12.706496809175452e-0022001-05-01T00:00:002001-05-01T00:00:00Sensitivity and Specificity22.704351343603116e-0021994-04-01T00:00:002004-02-01T00:00:00Biomechanical Phenomena12.698739289217863e-0022022-04-04T00:00:002022-04-04T00:00:00Homeodomain Proteins22.695172340229072e-0021997-06-01T00:00:002001-05-01T00:00:00Aorta, Thoracic12.685341369181172e-0022001-05-01T00:00:002001-05-01T00:00:00Acetates12.682990765001587e-0021996-03-08T00:00:001996-03-08T00:00:00Databases, Genetic12.679220091687971e-0022021-07-14T00:00:002021-07-14T00:00:00Cytokines22.678152551345438e-0022017-07-24T00:00:002021-06-23T00:00:00Neuroglia12.676749310733777e-0022020-10-19T00:00:002020-10-19T00:00:00Whole Genome Sequencing12.671575523969166e-0022021-07-14T00:00:002021-07-14T00:00:00Thyroid Gland22.666800282054846e-0022011-02-24T00:00:002011-11-16T00:00:00Self-Evaluation Programs12.663270039179946e-0021994-02-01T00:00:001994-02-01T00:00:00Mice, Inbred BALB C22.661873133318906e-0021997-12-15T00:00:002000-07-24T00:00:00Neurotoxins12.657588809058306e-0021995-09-01T00:00:001995-09-01T00:00:00Interferon-gamma12.644563111910952e-0022022-10-25T00:00:002022-10-25T00:00:00Disease Progression22.638054204879662e-0022015-12-23T00:00:002025-10-22T00:00:00Affective Symptoms12.623613184084652e-0021977-01-01T00:00:001977-01-01T00:00:00Europe12.621901693476254e-0022021-02-17T00:00:002021-02-17T00:00:00Gene Transfer Techniques12.619215833716900e-0021999-08-01T00:00:001999-08-01T00:00:00Dinoprostone12.615477728223736e-0022016-11-01T00:00:002016-11-01T00:00:00Hemochromatosis Protein12.612744400188415e-0022014-07-21T00:00:002014-07-21T00:00:00Osteoporosis12.612533102779791e-0022003-12-30T00:00:002003-12-30T00:00:00Splenectomy12.583111237288952e-0022015-10-01T00:00:002015-10-01T00:00:00Molecular Probes12.577624426346855e-0021995-10-01T00:00:001995-10-01T00:00:00Metabolic Syndrome12.577510937342643e-0022025-02-24T00:00:002025-02-24T00:00:00Risk22.563900529954562e-0022015-05-01T00:00:002015-12-23T00:00:00Antigens, Polyomavirus Transforming12.553323980610768e-0021994-09-01T00:00:001994-09-01T00:00:00Glycine Plasma Membrane Transport Proteins12.551965659986706e-0022013-10-01T00:00:002013-10-01T00:00:00Adult Children12.541629473287218e-0022014-07-21T00:00:002014-07-21T00:00:00Toll-Like Receptor 312.536978065401520e-0022014-08-06T00:00:002014-08-06T00:00:00Coronary Artery Bypass22.525453852148969e-0021995-09-01T00:00:002009-05-03T00:00:00Infection Control12.519201299676270e-0022021-02-17T00:00:002021-02-17T00:00:00Myosin Heavy Chains12.499437877320771e-0022015-05-01T00:00:002015-05-01T00:00:00Biopsy, Needle12.494272363203449e-0022018-07-02T00:00:002018-07-02T00:00:00Host-Parasite Interactions12.469146831259568e-0022015-10-12T00:00:002015-10-12T00:00:00Podoplanin12.459370347358237e-0022012-12-31T00:00:002012-12-31T00:00:00Phosphoproteins22.453841363862975e-0021979-10-01T00:00:001998-12-01T00:00:00Prevalence22.453418919161225e-0022003-02-01T00:00:002017-11-23T00:00:00Sequence Analysis, RNA12.449949525463199e-0022021-08-01T00:00:002021-08-01T00:00:00Epinephrine12.446800137580821e-0022016-11-01T00:00:002016-11-01T00:00:00Osteopetrosis12.435922627323136e-0022013-01-22T00:00:002013-01-22T00:00:00Radioimmunoassay12.434648545165454e-0021993-10-01T00:00:001993-10-01T00:00:00Guanylate Cyclase12.432552069262601e-0022013-12-18T00:00:002013-12-18T00:00:00Periodontitis12.416598616745675e-0021999-01-01T00:00:001999-01-01T00:00:00Meta-Analysis as Topic12.414626787160112e-0022018-02-01T00:00:002018-02-01T00:00:00Neomycin12.398507759333918e-0022012-10-11T00:00:002012-10-11T00:00:00Papio12.383559610639944e-0022014-05-07T00:00:002014-05-07T00:00:00Oncogene Proteins, Fusion12.380230831483045e-0022021-07-14T00:00:002021-07-14T00:00:00Neoplasm Invasiveness32.378299311400660e-0022003-08-04T00:00:002007-03-01T00:00:00Mutagenesis, Insertional12.376417436453540e-0021995-11-01T00:00:001995-11-01T00:00:00Endopeptidases12.368883733619546e-0021996-06-01T00:00:001996-06-01T00:00:00Endoplasmic Reticulum12.365763067802214e-0022019-02-07T00:00:002019-02-07T00:00:00Biotin12.357262039014762e-0021993-10-01T00:00:001993-10-01T00:00:00Cyclic GMP12.350698489460345e-0022013-12-18T00:00:002013-12-18T00:00:00Transforming Growth Factor beta12.350042614383528e-0022020-06-15T00:00:002020-06-15T00:00:00Culture Media12.337852748173266e-0021994-11-01T00:00:001994-11-01T00:00:00Pregnancy52.337446613118875e-0021996-09-20T00:00:002023-10-27T00:00:00Receptors, Tumor Necrosis Factor, Type I12.336198931303364e-0022013-07-31T00:00:002013-07-31T00:00:00Single-Cell Analysis12.331267881800071e-0022025-05-05T00:00:002025-05-05T00:00:00Bortezomib12.325966500502906e-0022016-10-14T00:00:002016-10-14T00:00:00Myelin Sheath12.302136382327371e-0022016-07-20T00:00:002016-07-20T00:00:00Pulmonary Artery12.294754850182599e-0022001-05-01T00:00:002001-05-01T00:00:00Forkhead Transcription Factors12.290781459220992e-0022019-10-22T00:00:002019-10-22T00:00:00Risk Factors42.279357718772418e-0022014-08-06T00:00:002024-11-25T00:00:00Guanosine Diphosphate12.273845825627033e-0022011-12-22T00:00:002011-12-22T00:00:00Coronary Circulation12.270825835942478e-0021998-06-01T00:00:001998-06-01T00:00:00High-Throughput Nucleotide Sequencing22.270186810552227e-0022013-02-10T00:00:002016-05-05T00:00:00Cytosine12.243963060203914e-0022013-02-10T00:00:002013-02-10T00:00:00Geography12.240570914071038e-0022014-05-07T00:00:002014-05-07T00:00:00Africa12.222541676817506e-0022014-05-07T00:00:002014-05-07T00:00:00Demography12.221609545465450e-0022016-10-14T00:00:002016-10-14T00:00:00Heat Shock Transcription Factors12.216661421025892e-0022011-11-30T00:00:002011-11-30T00:00:00rab11 GTP-Binding Proteins12.212930679706102e-0022011-07-20T00:00:002011-07-20T00:00:00Treatment Outcome32.209540705978250e-0022002-05-01T00:00:002015-03-04T00:00:00Erythropoietin12.204462439014517e-0021996-02-01T00:00:001996-02-01T00:00:00Hypertrophy12.203988338127476e-0022013-09-01T00:00:002013-09-01T00:00:00Gene Expression Regulation, Neoplastic32.200276194528670e-0022001-04-02T00:00:002021-07-14T00:00:00STAT3 Transcription Factor12.194078593972234e-0022015-12-23T00:00:002015-12-23T00:00:00Astrocytes12.181646133659203e-0022020-01-18T00:00:002020-01-18T00:00:00Hypersensitivity, Immediate12.173233200413741e-0021994-05-01T00:00:001994-05-01T00:00:00Neurosurgical Procedures12.168366232879637e-0022023-04-04T00:00:002023-04-04T00:00:00Iodides12.162601166525106e-0022011-02-24T00:00:002011-02-24T00:00:00Temporal Bone12.151784272939756e-0022015-10-20T00:00:002015-10-20T00:00:00Inflammation Mediators12.147142796461493e-0022020-03-09T00:00:002020-03-09T00:00:00Aortic Valve Insufficiency12.144295468557467e-0021995-09-01T00:00:001995-09-01T00:00:00Mice, Inbred ICR12.141425840994558e-0022011-11-30T00:00:002011-11-30T00:00:00Transgenes22.139057537185430e-0022004-04-30T00:00:002005-04-06T00:00:00Guanosine Triphosphate12.134481794272821e-0022011-12-22T00:00:002011-12-22T00:00:00Tretinoin12.134396033128356e-0021994-04-01T00:00:001994-04-01T00:00:00Mutant Proteins12.113885804525236e-0022013-01-22T00:00:002013-01-22T00:00:00Infant, Newborn12.106993294066378e-0022011-08-17T00:00:002011-08-17T00:00:00Genes, Bacterial12.104770152900801e-0021994-10-01T00:00:001994-10-01T00:00:00ADP-Ribosylation Factors12.102832659794169e-0022011-07-20T00:00:002011-07-20T00:00:00Cricetinae12.099579262972160e-0021994-09-01T00:00:001994-09-01T00:00:00Tumor Suppressor Proteins12.098172810636849e-0022001-04-02T00:00:002001-04-02T00:00:00Disability Evaluation12.088439521162035e-0021978-04-01T00:00:001978-04-01T00:00:00Scaffold Protein ILK12.074366822253759e-0022010-06-24T00:00:002010-06-24T00:00:00Mental Recall12.073183255564267e-0021977-03-01T00:00:001977-03-01T00:00:00COVID-1912.067737692966989e-0022021-02-17T00:00:002021-02-17T00:00:00Down-Regulation32.039149146299038e-0021999-02-01T00:00:002004-12-01T00:00:00Carbonic Anhydrase III12.027001245952262e-0022010-01-28T00:00:002010-01-28T00:00:00Vascular Endothelial Growth Factor A12.018035035954396e-0022021-08-25T00:00:002021-08-25T00:00:00Ion Pumps12.012498156222226e-0022010-01-28T00:00:002010-01-28T00:00:00Autistic Disorder12.012076971757866e-0022000-04-01T00:00:002000-04-01T00:00:00Mice, SCID22.009334772305809e-0022003-08-04T00:00:002007-03-01T00:00:00Proteolysis12.002365545043505e-0022016-10-14T00:00:002016-10-14T00:00:00Enzyme Activation11.997940873055244e-0022015-12-23T00:00:002015-12-23T00:00:00Gastrin-Releasing Peptide11.984371312828858e-0022009-11-22T00:00:002009-11-22T00:00:00Prospective Studies41.984133879819955e-0022013-09-01T00:00:002016-10-21T00:00:00Learning21.978591393287354e-0021977-03-01T00:00:001994-07-01T00:00:00Epigenesis, Genetic11.960111144379473e-0022024-04-04T00:00:002024-04-04T00:00:00Animals, Genetically Modified21.956508978497094e-0022003-05-01T00:00:002005-04-06T00:00:00Proteasome Endopeptidase Complex11.956141907331764e-0022016-10-14T00:00:002016-10-14T00:00:00Calcium-Calmodulin-Dependent Protein Kinase Type 211.947527762379538e-0022010-11-04T00:00:002010-11-04T00:00:00Indoles21.947297245850685e-0022008-08-01T00:00:002008-09-30T00:00:00Protein-Tyrosine Kinases11.945437208183860e-0021999-02-01T00:00:001999-02-01T00:00:00rab GTP-Binding Proteins11.940635798842593e-0022011-07-20T00:00:002011-07-20T00:00:00Cell Differentiation21.938487900555797e-0021998-08-21T00:00:002016-10-14T00:00:00Hematocrit31.936354311043882e-0021994-01-01T00:00:001996-03-01T00:00:00Saccharomyces cerevisiae Proteins11.900219785274439e-0021999-02-16T00:00:001999-02-16T00:00:00Two-Hybrid System Techniques11.895383484918969e-0022010-06-24T00:00:002010-06-24T00:00:00Antioxidants11.878616448787530e-0022017-07-10T00:00:002017-07-10T00:00:00Primary Cell Culture11.876664504098547e-0022011-07-20T00:00:002011-07-20T00:00:00Vasoactive Intestinal Peptide11.867840154605260e-0022009-11-22T00:00:002009-11-22T00:00:00Protein Interaction Domains and Motifs11.861480888660013e-0022011-07-20T00:00:002011-07-20T00:00:00Thiazolidines11.858294223339981e-0022009-04-02T00:00:002009-04-02T00:00:00Green Fluorescent Proteins21.857921078871900e-0021996-06-01T00:00:002009-10-12T00:00:00Titrimetry11.857762350336915e-0022008-11-12T00:00:002008-11-12T00:00:00Nitrogen Isotopes11.849405143978673e-0022009-03-14T00:00:002009-03-14T00:00:00Hemodynamics11.848720913489032e-0021999-12-01T00:00:001999-12-01T00:00:00Thromboembolism11.847031449364408e-0022015-10-01T00:00:002015-10-01T00:00:00Respiratory System11.841158913718019e-0022012-07-16T00:00:002012-07-16T00:00:00H(+)-K(+)-Exchanging ATPase11.839459610147528e-0022008-11-12T00:00:002008-11-12T00:00:00Hemorrhage11.838842246426006e-0022021-06-23T00:00:002021-06-23T00:00:00Mice, Inbred AKR21.833786521329899e-0021994-12-01T00:00:002001-10-01T00:00:00Computational Biology11.829069818648706e-0022021-07-14T00:00:002021-07-14T00:00:00Cresols11.828063618471259e-0022008-09-30T00:00:002008-09-30T00:00:00Apamin11.826433825097412e-0022008-08-01T00:00:002008-08-01T00:00:00Macaca mulatta11.824847682642177e-0022015-10-12T00:00:002015-10-12T00:00:0015-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid11.821140476819828e-0022008-08-01T00:00:002008-08-01T00:00:00Staurosporine21.816311130100864e-0021997-11-01T00:00:002001-10-01T00:00:00Quantitative Trait Loci11.803940842901167e-0022017-05-13T00:00:002017-05-13T00:00:00Perfusion21.792950844875048e-0021997-08-01T00:00:002009-04-02T00:00:00Anisotropy11.779502440542453e-0022011-12-22T00:00:002011-12-22T00:00:00Intestines11.777391555714420e-0021997-12-15T00:00:001997-12-15T00:00:00Counseling11.763714365597755e-0021977-01-01T00:00:001977-01-01T00:00:00Restriction Mapping21.759470984123212e-0021995-10-13T00:00:002001-09-25T00:00:00Vasomotor System11.759014684766580e-0022009-05-03T00:00:002009-05-03T00:00:00Magnetic Resonance Imaging31.740365385153692e-0022013-09-01T00:00:002023-10-04T00:00:00CRISPR-Cas Systems11.738545654193933e-0022019-07-02T00:00:002019-07-02T00:00:00Carbon Isotopes11.738256563640162e-0022009-03-14T00:00:002009-03-14T00:00:00Vasopressins11.737262711210000e-0022009-11-22T00:00:002009-11-22T00:00:00Cyclin-Dependent Kinase Inhibitor p1611.735466911610594e-0022012-01-07T00:00:002012-01-07T00:00:00HeLa Cells11.725917763059771e-0021994-04-01T00:00:001994-04-01T00:00:00Cell Movement11.723702897104688e-0022000-05-01T00:00:002000-05-01T00:00:00Electrophysiological Phenomena11.722192695838030e-0022010-01-28T00:00:002010-01-28T00:00:00Gene Targeting21.709435192974729e-0021996-09-20T00:00:002004-09-03T00:00:00Hydrogen Peroxide11.708537009479067e-0022011-10-31T00:00:002011-10-31T00:00:00Membrane Microdomains11.696295365573831e-0022009-04-22T00:00:002009-04-22T00:00:00Ear, Inner11.690609382440719e-0022011-11-16T00:00:002011-11-16T00:00:00Biomarkers31.676951725487076e-0022007-10-01T00:00:002021-06-07T00:00:00Erythrocyte Volume11.666603214079545e-0022007-05-17T00:00:002007-05-17T00:00:00Carbonic Anhydrase IX11.655772014921334e-0022007-07-25T00:00:002007-07-25T00:00:00Buffers21.655689758330221e-0021997-05-01T00:00:001997-08-01T00:00:00Antibodies21.655615132447421e-0021989-07-01T00:00:001999-12-01T00:00:00Memory11.652794429331114e-0021977-03-01T00:00:001977-03-01T00:00:00Terminology as Topic11.650408900975647e-0022015-03-04T00:00:002015-03-04T00:00:00Reticulocytosis11.644438814244231e-0022007-01-24T00:00:002007-01-24T00:00:00Myocardial Reperfusion11.644110945068456e-0022008-09-30T00:00:002008-09-30T00:00:00Benzoates11.643083572291650e-0022009-04-02T00:00:002009-04-02T00:00:00Sulfonamides11.640591489203223e-0022017-07-10T00:00:002017-07-10T00:00:00Reticulocyte Count11.636364310562542e-0022007-01-24T00:00:002007-01-24T00:00:00Ionomycin11.623737784938853e-0022007-01-24T00:00:002007-01-24T00:00:00Ovarian Neoplasms11.618120814711630e-0022004-07-19T00:00:002004-07-19T00:00:00Induced Pluripotent Stem Cells11.617362757673775e-0022019-07-25T00:00:002019-07-25T00:00:00Acid-Base Imbalance11.606414311898821e-0022007-04-04T00:00:002007-04-04T00:00:00Hepatocytes11.604391468585931e-0022014-07-21T00:00:002014-07-21T00:00:00Annexin A511.592947213955969e-0022007-01-24T00:00:002007-01-24T00:00:00Nephrocalcinosis11.585098585043371e-0022007-04-04T00:00:002007-04-04T00:00:00Antibodies, Blocking11.584341442041786e-0022007-07-25T00:00:002007-07-25T00:00:00Nerve Tissue Proteins11.583905598821851e-0021999-10-01T00:00:001999-10-01T00:00:00Electrolytes11.573676511603688e-0022007-09-21T00:00:002007-09-21T00:00:00Republic of Korea11.567964782631363e-0022009-10-01T00:00:002009-10-01T00:00:00DNA, Recombinant11.562999188218173e-0021987-03-01T00:00:001987-03-01T00:00:00Kidney Transplantation11.549719382647658e-0022002-05-01T00:00:002002-05-01T00:00:00HIV-111.543331871698332e-0022003-12-30T00:00:002003-12-30T00:00:00Sucrose11.535018838721967e-0022007-01-24T00:00:002007-01-24T00:00:00Heart Failure11.532979210421980e-0022010-11-04T00:00:002010-11-04T00:00:00Microtubule-Associated Proteins11.531208313356177e-0022011-07-20T00:00:002011-07-20T00:00:00Tetradecanoylphorbol Acetate21.529435356934379e-0021997-05-01T00:00:001997-11-01T00:00:00Drug Synergism21.527655056170556e-0021996-02-01T00:00:002003-12-30T00:00:00Acute Disease11.521004643608687e-0021997-01-01T00:00:001997-01-01T00:00:00Amyloid beta-Peptides11.518499594305733e-0022020-01-18T00:00:002020-01-18T00:00:00Consensus11.510759493020445e-0022015-03-04T00:00:002015-03-04T00:00:00Genetic Loci11.501513234380577e-0022015-05-01T00:00:002015-05-01T00:00:00Students11.496271877770110e-0021977-01-01T00:00:001977-01-01T00:00:00Feasibility Studies11.479218887089883e-0022017-07-24T00:00:002017-07-24T00:00:00Software21.468365324867944e-0021995-02-01T00:00:001997-06-01T00:00:00Lipid Peroxidation11.467620400573779e-0022006-11-01T00:00:002006-11-01T00:00:00Phosphatidylserines11.461753025469840e-0022007-01-24T00:00:002007-01-24T00:00:00Proto-Oncogene Proteins c-hck11.458306391138234e-0022005-11-11T00:00:002005-11-11T00:00:00Outcome and Process Assessment, Health Care11.456402296497561e-0021993-06-01T00:00:001993-06-01T00:00:00Proto-Oncogene Proteins31.451081847503866e-0021997-06-01T00:00:002005-11-11T00:00:00Carcinoma, Renal Cell11.442723977203554e-0022001-04-02T00:00:002001-04-02T00:00:00Lipopolysaccharides11.430799960553653e-0022013-07-31T00:00:002013-07-31T00:00:00Repressor Proteins11.423605108935184e-0021996-06-01T00:00:001996-06-01T00:00:00Family11.419867110687971e-0022016-05-05T00:00:002016-05-05T00:00:00Catalytic Domain11.409567382545736e-0022007-07-25T00:00:002007-07-25T00:00:00Pediatrics11.407841832912878e-0022021-02-17T00:00:002021-02-17T00:00:00Phenylurea Compounds11.400262648765328e-0022008-09-30T00:00:002008-09-30T00:00:00Potassium Compounds11.399404131986930e-0022004-12-01T00:00:002004-12-01T00:00:00Retrospective Studies41.395040934490116e-0022002-05-01T00:00:002018-07-02T00:00:00Sequence Homology11.387289623540402e-0022005-04-06T00:00:002005-04-06T00:00:00Heart Rate11.370074836399200e-0022016-11-01T00:00:002016-11-01T00:00:00Receptor, IGF Type 111.362573473458458e-0022007-03-01T00:00:002007-03-01T00:00:00Achlorhydria11.361839990846875e-0022004-04-30T00:00:002004-04-30T00:00:00Pseudomonas Infections11.329917652491454e-0022009-04-22T00:00:002009-04-22T00:00:00Muscles11.325265067785033e-0021989-04-01T00:00:001989-04-01T00:00:00Dietary Supplements11.312305652725011e-0021997-10-01T00:00:001997-10-01T00:00:00Platelet Count11.309226671207086e-0022007-01-24T00:00:002007-01-24T00:00:00Sublingual Gland11.293765271925130e-0022003-09-04T00:00:002003-09-04T00:00:00Integrin alpha6beta411.280947878852277e-0022003-08-04T00:00:002003-08-04T00:00:00Muscarinic Agonists11.274665444232073e-0022003-12-30T00:00:002003-12-30T00:00:00Postoperative Period11.270699624928166e-0022008-09-30T00:00:002008-09-30T00:00:00Motivation11.267710536120912e-0021994-02-01T00:00:001994-02-01T00:00:00Pilot Projects11.263828409897933e-0022017-07-24T00:00:002017-07-24T00:00:00Carbachol11.257459020490444e-0022003-12-30T00:00:002003-12-30T00:00:00Anemia, Dyserythropoietic, Congenital11.255910323395574e-0022003-05-01T00:00:002003-05-01T00:00:00Aquaporin 111.243473505465535e-0022003-03-26T00:00:002003-03-26T00:00:00src Homology Domains11.225180522076600e-0022004-09-27T00:00:002004-09-27T00:00:00Integrin alphaVbeta311.204894482590965e-0022003-08-04T00:00:002003-08-04T00:00:00Antibodies, Monoclonal21.200170841942005e-0021996-08-13T00:00:001997-12-01T00:00:00China11.195179022466496e-0022009-06-09T00:00:002009-06-09T00:00:00Attitude21.182173365182400e-0021977-01-01T00:00:001978-04-01T00:00:00CDC2 Protein Kinase11.174630354889445e-0022003-08-04T00:00:002003-08-04T00:00:00White Matter11.172249161123057e-0022016-07-20T00:00:002016-07-20T00:00:00Models, Theoretical11.168505241925116e-0022014-05-07T00:00:002014-05-07T00:00:00Obesity11.161687859320797e-0022025-02-24T00:00:002025-02-24T00:00:00Sex Characteristics11.153728424733996e-0022013-03-12T00:00:002013-03-12T00:00:00Genome, Human11.141773782675813e-0022015-05-01T00:00:002015-05-01T00:00:00Fibroblasts11.135051446787919e-0022012-12-31T00:00:002012-12-31T00:00:00Rats, Inbred F34411.132863704282972e-0022003-03-26T00:00:002003-03-26T00:00:00Okadaic Acid11.129751842219571e-0022001-10-01T00:00:002001-10-01T00:00:00Abscisic Acid11.110850873658151e-0022001-09-25T00:00:002001-09-25T00:00:00Genetic Diseases, Inborn11.108184208595440e-0021987-03-01T00:00:001987-03-01T00:00:00Registries11.103106690664048e-0022018-07-02T00:00:002018-07-02T00:00:00Plants, Genetically Modified11.096623152516038e-0022001-09-25T00:00:002001-09-25T00:00:00Heart11.089569090023473e-0021994-10-01T00:00:001994-10-01T00:00:00Respiratory Tract Infections11.069996421248231e-0022009-04-22T00:00:002009-04-22T00:00:00Thionucleotides11.040117303411979e-0022000-10-01T00:00:002000-10-01T00:00:00Adaptor Proteins, Signal Transducing11.033817342932664e-0022011-07-20T00:00:002011-07-20T00:00:00Mice, Inbred C3H11.015848157494217e-0022001-10-01T00:00:002001-10-01T00:00:00Kv1.3 Potassium Channel11.001793149823260e-0021999-12-01T00:00:001999-12-01T00:00:00Salts11.000707665207156e-0022000-05-01T00:00:002000-05-01T00:00:00Kv1.2 Potassium Channel19.945717606889537e-0031999-12-01T00:00:001999-12-01T00:00:00Microscopy, Video19.943990942133739e-0032000-09-01T00:00:002000-09-01T00:00:00Intensive Care Units19.910693673116814e-0032013-11-01T00:00:002013-11-01T00:00:00Trypsin19.906783265644712e-0031980-11-25T00:00:001980-11-25T00:00:00Kv1.1 Potassium Channel19.834146040308866e-0031999-12-01T00:00:001999-12-01T00:00:00Salivary Ducts19.815224888891316e-0031999-12-01T00:00:001999-12-01T00:00:00Neoplasm Transplantation19.727696682199204e-0032003-08-04T00:00:002003-08-04T00:00:00Retinoblastoma Protein19.655994461510459e-0032003-08-04T00:00:002003-08-04T00:00:00Breast Neoplasms19.557865665723425e-0032007-03-01T00:00:002007-03-01T00:00:00Curriculum19.441959116437979e-0031993-06-01T00:00:001993-06-01T00:00:00Guanidines19.439681272615946e-0032000-05-01T00:00:002000-05-01T00:00:00Barium Compounds19.417225202809869e-0031999-02-01T00:00:001999-02-01T00:00:00Inactivation, Metabolic19.364445956252793e-0031999-02-16T00:00:001999-02-16T00:00:00Prednisolone19.258786824153320e-0032000-05-01T00:00:002000-05-01T00:00:00Saliva19.233235370713491e-0032004-09-03T00:00:002004-09-03T00:00:00Von Hippel-Lindau Tumor Suppressor Protein19.231690453518179e-0032001-04-02T00:00:002001-04-02T00:00:00Autoradiography19.139604236462704e-0031999-12-01T00:00:001999-12-01T00:00:00Absorption18.963392714198749e-0031998-09-01T00:00:001998-09-01T00:00:00Lung18.959548752880768e-0031997-08-01T00:00:001997-08-01T00:00:00RNA, Neoplasm18.876758419108814e-0032001-04-02T00:00:002001-04-02T00:00:00Organ of Corti18.855203687558559e-0031998-11-11T00:00:001998-11-11T00:00:00Predictive Value of Tests18.835408093281235e-0032015-03-04T00:00:002015-03-04T00:00:00Organ Specificity18.790709645478496e-0032003-06-01T00:00:002003-06-01T00:00:00Xenograft Model Antitumor Assays18.750926848155550e-0032007-03-01T00:00:002007-03-01T00:00:00Endolymph18.599029905078175e-0031997-12-01T00:00:001997-12-01T00:00:00Cytochalasin D18.546663329904227e-0031997-11-01T00:00:001997-11-01T00:00:00Genistein18.421488260996696e-0031997-11-01T00:00:001997-11-01T00:00:00Lung Neoplasms18.419807134303731e-0032002-10-01T00:00:002002-10-01T00:00:00Cholera Toxin18.382973237231675e-0031980-05-25T00:00:001980-05-25T00:00:00Sulfones18.325495347314159e-0032000-05-01T00:00:002000-05-01T00:00:00Rana esculenta18.312524284198850e-0031997-03-15T00:00:001997-03-15T00:00:00Endolymphatic Sac18.257215826950418e-0031997-12-01T00:00:001997-12-01T00:00:00Fura-218.222408071757619e-0031997-05-01T00:00:001997-05-01T00:00:00Children with Disabilities18.214293737931764e-0032000-04-01T00:00:002000-04-01T00:00:00Reinforcement, Social18.144101033570139e-0031977-01-01T00:00:001977-01-01T00:00:00Education18.104865392102378e-0032000-04-01T00:00:002000-04-01T00:00:00Peptide Hydrolases18.099215499762957e-0031980-05-25T00:00:001980-05-25T00:00:00Exocytosis18.054926717381445e-0031978-09-28T00:00:001978-09-28T00:00:00HIV Infections18.041485343964497e-0032003-12-30T00:00:002003-12-30T00:00:00In Situ Hybridization, Fluorescence18.016187780730023e-0032003-05-01T00:00:002003-05-01T00:00:00Intelligence Tests17.932507437288221e-0031978-04-01T00:00:001978-04-01T00:00:00Proto-Oncogene Proteins c-myb17.897719659698654e-0031997-06-01T00:00:001997-06-01T00:00:00Risk Assessment17.854390159941205e-0032018-07-02T00:00:002018-07-02T00:00:00Hematologic Tests17.796199284562070e-0031997-10-01T00:00:001997-10-01T00:00:00Cosmids17.766413180768911e-0031996-05-01T00:00:001996-05-01T00:00:00Education, Special17.759686784305091e-0031977-01-01T00:00:001977-01-01T00:00:00Body Weight17.759560273948708e-0032007-07-25T00:00:002007-07-25T00:00:00Transplantation, Heterologous17.739755239523648e-0032003-08-04T00:00:002003-08-04T00:00:00Plasmids17.628287008265896e-0032001-09-25T00:00:002001-09-25T00:00:00Aquaporin 617.583914038730336e-0031995-12-01T00:00:001995-12-01T00:00:00Superoxides17.555908604417479e-0031997-08-01T00:00:001997-08-01T00:00:00Lac Operon17.523802984318451e-0031996-04-16T00:00:001996-04-16T00:00:00Erythrocyte Count17.314449886226453e-0031996-02-01T00:00:001996-02-01T00:00:00United States27.268983028401928e-0032009-06-09T00:00:002017-11-23T00:00:00Cerebellum17.185228720502100e-0032003-03-28T00:00:002003-03-28T00:00:00Oxidative Stress17.152930120120042e-0032006-11-01T00:00:002006-11-01T00:00:00Oxidation-Reduction17.119251349820545e-0032001-10-01T00:00:002001-10-01T00:00:00beta-Galactosidase17.017024027850437e-0031996-04-16T00:00:001996-04-16T00:00:00Aquaporin 216.975058987535040e-0031995-12-01T00:00:001995-12-01T00:00:00Genes, Switch16.920107308935438e-0031994-10-01T00:00:001994-10-01T00:00:00Embryonic and Fetal Development16.910525064382572e-0031995-10-13T00:00:001995-10-13T00:00:00Crosses, Genetic16.905731718377647e-0031996-03-01T00:00:001996-03-01T00:00:00Electric Stimulation16.822309748522179e-0031999-12-01T00:00:001999-12-01T00:00:00Miconazole16.777840674371559e-0031994-04-01T00:00:001994-04-01T00:00:00Pulmonary Edema16.760882988302499e-0031997-08-01T00:00:001997-08-01T00:00:00Adenine Nucleotides16.758302790337114e-0031994-10-01T00:00:001994-10-01T00:00:00Reinforcement, Psychology16.734907087535292e-0031977-01-01T00:00:001977-01-01T00:00:00Drug Administration Schedule16.702999191807221e-0032002-05-01T00:00:002002-05-01T00:00:00Microscopy, Electron, Scanning16.685010268945100e-0031996-09-20T00:00:001996-09-20T00:00:00Microsomes, Liver16.684537976130381e-0031974-06-26T00:00:001974-06-26T00:00:00Cell Survival16.675463719583201e-0032004-04-30T00:00:002004-04-30T00:00:00Neovascularization, Physiologic16.674664278116127e-0032002-01-01T00:00:002002-01-01T00:00:00Freeze Fracturing16.620185214874841e-0031994-01-01T00:00:001994-01-01T00:00:00Trachea16.583186683913052e-0032000-10-01T00:00:002000-10-01T00:00:00Gadolinium16.482371589775404e-0031999-02-01T00:00:001999-02-01T00:00:00Mental Disorders16.479947149043278e-0031994-07-01T00:00:001994-07-01T00:00:00Organ Culture Techniques16.246879364828943e-0031995-10-13T00:00:001995-10-13T00:00:00Luminescent Proteins16.241551373401408e-0031996-06-01T00:00:001996-06-01T00:00:00Molecular Structure16.121981296368117e-0031997-12-15T00:00:001997-12-15T00:00:00Diastole16.083851667921449e-0031995-09-01T00:00:001995-09-01T00:00:00Isoenzymes15.946922563453416e-0031997-06-01T00:00:001997-06-01T00:00:00Acyltransferases15.884442972378559e-0031974-06-26T00:00:001974-06-26T00:00:00Genes15.878658247258382e-0031996-05-01T00:00:001996-05-01T00:00:00Follow-Up Studies15.752089639824101e-0031994-02-01T00:00:001994-02-01T00:00:00Cell Transformation, Neoplastic15.718541032405744e-0032002-01-01T00:00:002002-01-01T00:00:00Cytomegalovirus15.649297318466133e-0031997-05-01T00:00:001997-05-01T00:00:00CD4-Positive T-Lymphocytes15.607682809377464e-0032004-09-03T00:00:002004-09-03T00:00:00Bilirubin15.598020008371039e-0031994-01-01T00:00:001994-01-01T00:00:00Neovascularization, Pathologic15.578579476073642e-0032002-01-01T00:00:002002-01-01T00:00:00Cysts15.548174460380736e-0031997-05-01T00:00:001997-05-01T00:00:00Intraoperative Care15.466597888925655e-0031995-09-01T00:00:001995-09-01T00:00:00Mast Cells15.415663681038271e-0031978-09-28T00:00:001978-09-28T00:00:00Amino Acids15.238786359228458e-0031997-07-01T00:00:001997-07-01T00:00:00Educational Measurement15.131505246344517e-0031978-04-01T00:00:001978-04-01T00:00:00Teaching15.106754383044349e-0031978-04-01T00:00:001978-04-01T00:00:00Catheterization15.000958288062624e-0031995-09-01T00:00:001995-09-01T00:00:00Hippocampus14.992376467796672e-0032003-03-28T00:00:002003-03-28T00:00:00Antibodies, Bacterial14.991412905836181e-0031996-06-01T00:00:001996-06-01T00:00:00Drosophila14.980117124599538e-0031997-05-01T00:00:001997-05-01T00:00:00Memory Disorders14.900385160624696e-0031977-03-01T00:00:001977-03-01T00:00:00Tomography, X-Ray Computed14.891629401047855e-0032013-09-01T00:00:002013-09-01T00:00:00Single-Strand Specific DNA and RNA Endonucleases14.830113202287959e-0031989-05-15T00:00:001989-05-15T00:00:00Echocardiography, Transesophageal14.739248967857720e-0031995-09-01T00:00:001995-09-01T00:00:00DNA Restriction Enzymes14.670932535051416e-0031989-05-15T00:00:001989-05-15T00:00:00Catecholamines24.658654073617473e-0031979-10-01T00:00:001980-12-01T00:00:00Antineoplastic Agents14.570719730937754e-0032012-01-07T00:00:002012-01-07T00:00:00Adaptation, Psychological14.551473160119686e-0032000-04-01T00:00:002000-04-01T00:00:00Liver Diseases14.436723841689025e-0031997-05-01T00:00:001997-05-01T00:00:00Oligonucleotides, Antisense14.380059653793532e-0031991-11-01T00:00:001991-11-01T00:00:00DNA Probes14.356829822160834e-0031989-05-15T00:00:001989-05-15T00:00:00Trans-Activators14.313678953046797e-0031997-06-01T00:00:001997-06-01T00:00:00Radiography14.263800642598382e-0031999-01-01T00:00:001999-01-01T00:00:00Nucleic Acid Hybridization14.171056977013724e-0031989-05-15T00:00:001989-05-15T00:00:00Data Interpretation, Statistical14.165352829717716e-0031997-05-01T00:00:001997-05-01T00:00:00Endonucleases13.945527748787260e-0031989-05-15T00:00:001989-05-15T00:00:00Models, Genetic13.880131347422628e-0031996-07-12T00:00:001996-07-12T00:00:00Hypertension, Pulmonary13.762920062221778e-0031997-08-01T00:00:001997-08-01T00:00:00Postoperative Complications13.717899568720786e-0032009-05-03T00:00:002009-05-03T00:00:00Drug Therapy, Combination13.704291766011541e-0031996-02-01T00:00:001996-02-01T00:00:00Oxygen13.682994526024940e-0031997-08-01T00:00:001997-08-01T00:00:00Ventricular Function, Left12.866394334492916e-0031995-09-01T00:00:001995-09-01T00:00:00Carcinoma, Hepatocellular12.710733327310762e-0031974-06-26T00:00:001974-06-26T00:00:00Coronary Disease12.678192107739902e-0031995-09-01T00:00:001995-09-01T00:00:00Aging12.485415437579876e-0031999-12-01T00:00:001999-12-01T00:00:00p-Methoxy-N-methylphenethylamine12.288730793522314e-0031978-09-28T00:00:001978-09-28T00:00:00Palmitic Acids11.701632453615170e-0031974-06-26T00:00:001974-06-26T00:00:00Insulin11.700055472125378e-0031989-04-01T00:00:001989-04-01T00:00:00Chromatography, Thin Layer11.687384447660452e-0031974-06-26T00:00:001974-06-26T00:00:00Coenzyme A11.661960697572818e-0031974-06-26T00:00:001974-06-26T00:00:00Glycerol11.542581145493664e-0031974-06-26T00:00:001974-06-26T00:00:00Lipase11.416919706201435e-0031974-06-26T00:00:001974-06-26T00:00:00Neoplasms, Experimental11.180961695652509e-0031974-06-26T00:00:001974-06-26T00:00:00Liver Neoplasms15.360620671637291e-0041974-06-26T00:00:001974-06-26T00:00:00Michael Drake Alpert, M.D.MichaelAlpert

Cambridge Health AlliancePsychiatry Training - Macht Bldg1493 Cambridge StCambridge, MA 02139617/521-6730

1BIDMCBeth Israel Deaconess Medical CenterPsychiatryLecturer on Psychiatry, Part-timeLecturerAhmad Alshadad, M.B.,Ch.B.AhmadAlshadad

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/754-3470

1BIDMCBeth Israel Deaconess Medical CenterEmergency MedicineResearch Fellow in Emergency MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41431954Effectiveness of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) Event-Response Training in a Hospital Setting: A Scoping Review. Disaster Med Public Health Prep. 2025 Dec 23; 20:e2.Malek A, Hertelendy AJ, Alshaikh E, Alshadad A, Buhiji A, Ranse J, Boukai A, Woodward CA, Eboreime E, Kung J, Voskanyan A, Ciottone G, Issa F. Disaster Med Public Health Prep2025 Dec 2320:e2http://www.ncbi.nlm.nih.gov/pubmed/40702744Racing in Rising Global Temperatures: A Scoping Review of Heat-related Illnesses in Endurance Running. Disaster Med Public Health Prep. 2025 Jul 24; 19:e206.Görgens S, Hertelendy AJ, Issa F, Fernandez D, Alshadad A, Davis L, Franc JM, Kung J, Woodward CA, Voskanyan A, Ciottone G. Disaster Med Public Health Prep2025 Jul 2419:e206Heat Stress Disorders12.109545611034921e-0012025-07-24T00:00:002025-07-24T00:00:00Civil Defense12.096802881892836e-0012025-12-23T00:00:002025-12-23T00:00:00Inservice Training11.987026263107618e-0012025-12-23T00:00:002025-12-23T00:00:00Physical Endurance11.892857054058677e-0012025-07-24T00:00:002025-07-24T00:00:00Running11.621759585199496e-0012025-07-24T00:00:002025-07-24T00:00:00Teaching11.396142073275712e-0012025-12-23T00:00:002025-12-23T00:00:00Hospitals19.447134133409435e-0022025-12-23T00:00:002025-12-23T00:00:00Heat Stroke15.731229181922399e-0022025-07-24T00:00:002025-07-24T00:00:00Disaster Planning13.896599728674972e-0022025-12-23T00:00:002025-12-23T00:00:00Hot Temperature13.489973195504547e-0022025-07-24T00:00:002025-07-24T00:00:00Humans25.212957772437852e-0032025-07-24T00:00:002025-12-23T00:00:00David C. Alsop, Ph.D.DavidAlsop

Beth Israel Deaconess Med CtrRadiology330 Brookline AveBoston, MA 02215617/667-027542.34022770000000-71.10585400000000

1BIDMCBeth Israel Deaconess Medical CenterRadiologyProfessor of RadiologyFull ProfessorPrincipal InvestigatorDiagnostic Imaging of Cerebral Blood Flow with MRINIH2000-09-302005-08-31ALSOP, DAVID CHARLESImaging of Cerebral Blood Flow (CBF) is a powerful technique for the diagnostic evaluation of patients with dementia, stroke and epilepsy. A technique known as Arterial Spin Labeling MRI has demonstrated the ability to provide high quality images of CBF without radioactivity or injection. The advancement of this technique has been limited, however, by the destructive effects of patient motion, the poor image quality of the fast, echoplanar imaging technique used to combat these motion effects, and the inability to acquire images from the entire brain in a reasonable exam period. The applicants propose to overcome these limitations by refining a novel background suppression approach. Multiple inversion pulses will be used to reduce the intensity of uninteresting signals prior to image acquisition. This approach can reduce motion-related errors by a factor of 100 while preserving the CBF signal. Because of the dramatic reduction in motion-related errors, a superior, 3D fast spin echo imaging approach can be employed to provide CBF images from the whole brain in under 6 minutes with twice the sensitivity of earlier approaches. We propose to realize this potential of this approach by: 1. Optimizing the design of the RF pulses used for background suppression to minimize CBF signal loss and systematic errors near the top and bottom of the brain. 2. Using a nonlinear minimization strategy to optimize the timing of the inversions so as to achieve ideal background suppression 3. Developing a strategy for T1 quantification of brain tissue that will be compatible with the 3D fast spin echo sequence and which will be insensitive to the presence of cerebrospinal fluid(CSF). TI measurement is required for CBF measurement but can be contaminated by small amounts of CSF in the voxel. 4. Measuring the efficiency of the background suppressed sequences. Efficiency will be measured as a function of labeling plane location to guide the choice of parameters for subsequent applications. 5. Measuring the test-retest reliability of the optimized CBF imaging method in normal controls and patients with dementia and comparing it to unsuppressed methods. This information is needed for the design and interpretation of diagnostic tests, pharmaceutical evaluations and other studies employing CBF MRI. These developments will make reliable CBF imaging by Arterial Spin Labeling a widely applicable technique for diagnostic imaging.Principal InvestigatorBlood Flow MRI for Monitoring of Renal Cell CarcinomaNIH2006-08-152010-06-30ALSOP, DAVID CHARLESTumor blood flow is an important indicator of aggressiveness and prognosis. Recent research has emphasized that the ability to generate new blood vessels to supply a growing tumor, or angiogenesis, is a fundamental determinant of tumor viability and expansion. New therapies which aim to block angiogenesis have achieved startling success in animal studies and show promise in human trials. Evaluation of response to such agents in initial human studies would be greatly aided by the availability of techniques for noninvasive measurement of their effects. Since the target of antiangiogenesis is to block the expansion of blood supply, measurement of tumor blood flow should be an early and powerful indicator of response to therapy. Current methods for blood flow imaging and measurement in the body are quite limited, however. We propose to further develop and test an MRI method for imaging of blood flow. While more well-developed for imaging of the brain, the technique has not been fully optimized and evaluated for imaging within the body. We propose to fully optimize and evaluate this method for the imaging of blood flow in the abdomen and pelvis. First we will optimize blood flow measurement in a single slice and determine the timing and signal parameters necessary for reproducible and accurate results. Next we will implement methods to image a volume of the abdomen and pelvis in a short period of time. Finally, we will use the optimized method to measure blood flow in patients with renal cell carcinoma, to evaluate the reproducibility and accuracy of the blood flow measurement, and to measure modulations in kidney blood flow induced by a renal vasodilator. These studies will provide the necessary experience and validation to best use the MRI blood flow method for monitoring of patient response in studies of new experimental therapies. This research will improve and test a technique for making pictures of blood flow into tumors using MRI. Many new treatments for cancer try to stop tumor growth by restricting its blood supply. This MRI technique, if properly developed, may be useful for seeing whether these treatments are effective in some patients and for detecting failure of the treatment as early as possible so more effective treatments can be used. Principal InvestigatorBlood Flow MRI for Monitoring Glioma AngiogenesisNIH2006-08-182012-06-30ALSOP, DAVID CHARLESBlocking of new tumor blood vessel creation, or angiogenesis, starves the tumor by restricting the supply of nutrients carried by blood flow. Anti-angiogenesis is a promisiing new approach to oncology, but clinical trials have shown large intersubject variation in response. In glioma, a common and aggressive brain tumor, both drug resistant angiogenesis and invasion of tumor cells into surrounding tissue with a functioning blood supply may play a role in failure of antiangiogenic therapy. We propose the use of a noninvasive Magnetic Resonance Imaging (MRI) technique for blood flow as a marker for effective angiogenesis in patients with glioma. This new MRI technique uses magnetic fields to change the signal, or label, the magnetic water spins of inflowing arterial blood. This arterial spin labeling (ASL) approach can generate high quality maps of blood flow in just a few minutes as part of a routine MRI exam. This proposed study will provide the needed information and developments to enable the use of arterial spin labeling (ASL) blood flow MRI in clinical trials of experimental therapies for glioma. We will validate the technique as a marker for angiogenesis by correlating measured blood flow in tumors before surgical and/or radiation therapy with microvascular density measurements in biopsy specimens. We will assess the relationship between a Magnetic Resonance Spectroscopy choline metabolite measure (a suggested indicator of cellular proliferation) and the amount and spatial distribution of blood flow. We will determine the sensitivity limits for detecting changes in blood supply to a tumor by measuring the test-retest reliability of the technique in tumors. Finally, we will use MRI to monitor blood flow changes in and near brain tumors following surgical and radiation therapy. This will provide control data for future clinical trials and also determine the most sensitive combination of methods for detecting reccurence or progression of tumors. These studies will advance our two long term goals of improved testing of new therapies for glioma and improved treatment of glioma and other cancers. This research will determine if a new method for measuring blood flow into brain tumors could be useful for quantifying the effects of new treatments, especially those that target tumor blood vessels. If successful, this method could also become an important clinical tool for planning and monitoring therapy. Principal InvestigatorPerfusion MRI for Multi-site Studies of Brain FunctionNIH2007-09-272019-03-31ALSOP, DAVID CHARLESArterial Spin Labeling (ASL) perfusion MRI shows promise as a widely available and quantitative measure of resting brain function that can be used as a biomarker for the neural correlates of psychiatric and neurologic diseases, for the measurement of drug effects in the brain, and ultimately for diagnosis and treatment monitoring in individual patients. Although ASL perfusion MRI technologies are now implemented on most MRI scanner platforms, uncertainty in the community on the performance differences of various technical implementations and how to best use the technology across centers and MRI scanner platforms has limited its dissemination into routine use in clinical research. Building upon our successful development of quantification methods and standard sequences across platforms in the prior funding cycle, we propose to focus on the key issues limiting multi-center studies with ASL. Our first aim is to measure the relative sensitivity of different implementations of ASL by comparing their reproducibility and their response to 2 test interventions, citalopram or alprazolam administration. The result of this aim will be a quantitative calculation of power for detection of regional effects and how the choice of implementation will affect the power and required sample size. The second aim is to develop quality assessment methods using customized image acquisitions and the construction of a perfusion phantom. Quality assurance is a key element of imaging studies across sites, but there are no established methods for testing ASL perfusion performance. In our final aim, we target the characterization and reduction of variable perfusion signal induced by changes in brain activity unrelated to study interventions, so-called physiological noise. We will determine whether performing a moderately demanding vigilance task during the ASL scan will help control the subject's mental state and reduce variability without excessively stimulating particular regions of the brain. We will also study resting fluctuations in perfusion induced by network activity in the brain to determine if identifying and removing these fluctuations during image processing improves reproducibility. This aim will also determine if the amplitude of resting fluctuations is reflective of resting perfusion. Since resting brain fluctuations as measured by blood oxygenation sensitive MRI are increasingly being used as an indicator of resting function, establishing a relationship between fluctuations and average resting activity will address an outstanding question in functional imaging. Achievement of these aims will accelerate and improve the use of ASL as a biomarker for brain function in disease and will greatly improve the design of numerous planned and active multi-site studies employing ASL.http://www.ncbi.nlm.nih.gov/pubmed/41493597Perivascular Diffusivity Suggests Dynamic and Modifiable Glymphatic Transit in Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2026 Mar 01; 46(1):105-112.Bouffard MA, Comeau DS, Avanaki MA, Jaafar N, Brook A, Abbasi B, Alsop DC, Chang YM, Rizzo JF, Mallery RM, Chwalisz BK, Reinshagen KL, Grech O, Ford JN. J Neuroophthalmol2026 Mar 0146(1):105-112http://www.ncbi.nlm.nih.gov/pubmed/41222553Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram. Age Ageing. 2025 Oct 30; 54(11).Ning MH, Rodionov A, Ross JM, Ozdemir RA, Burch M, Lian SJ, Alsop D, Cavallari M, Dickerson B, Fong T, Jones RN, Libermann T, Marcantonio E, Santarnecchi E, Schmitt EM, Touroutoglou A, Travison T, Acker L, Smith MR, Sun H, Westover MB, Pascual-Leone Á, Berger M, Inouye SK, Shafi M. Age Ageing2025 Oct 3054(11)http://www.ncbi.nlm.nih.gov/pubmed/39902519Tissue-to-fluid water-exchange imaging using T2-selective saturation labeling. Magn Reson Med. 2025 Jul; 94(1):150-165.Taso M, Alsop DC. Magn Reson Med2025 Jul94(1):150-165http://www.ncbi.nlm.nih.gov/pubmed/40800493Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations. Imaging Neurosci (Camb). 2024; 2.Munsch F, Taso M, Wolf DH, Press D, Buss S, Detre JA, Alsop DC. Imaging Neurosci (Camb)20242http://www.ncbi.nlm.nih.gov/pubmed/39185530Prediction of Postoperative Delirium in Older Adults from Preoperative Cognition and Occipital Alpha Power from Resting-State Electroencephalogram. medRxiv. 2024 Nov 01.Ning M, Rodionov A, Ross JM, Ozdemir RA, Burch M, Lian SJ, Alsop D, Cavallari M, Dickerson BC, Fong TG, Jones RN, Libermann TA, Marcantonio ER, Santarnecchi E, Schmitt EM, Touroutoglou A, Travison TG, Acker L, Reese M, Sun H, Westover B, Berger M, Pascual-Leone A, Inouye SK, Shafi MM. medRxiv2024 Nov 01http://www.ncbi.nlm.nih.gov/pubmed/39228018MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension. J Neuroophthalmol. 2024 Sep 04; 45(3):321-326.Bouffard MA, Avanaki MA, Ford JN, Jaafar N, Brook A, Abbasi B, Torun N, Alsop D, Comeau DS, Chang YM. J Neuroophthalmol2024 Sep 0445(3):321-326http://www.ncbi.nlm.nih.gov/pubmed/39214436An improved spectral clustering method for accurate detection of brain resting-state networks. Neuroimage. 2024 Oct 01; 299:120811.Barrett J, Meng H, Zhang Z, Chen SM, Zhao L, Alsop DC, Qiao X, Dai W. Neuroimage2024 Oct 01299:120811http://www.ncbi.nlm.nih.gov/pubmed/40800347Inhomogeneous magnetization transfer (ihMT) imaging reveals variable recovery profiles of active MS lesions according to size and localization. Imaging Neurosci (Camb). 2024; 2.Soustelle L, Mchinda S, Hertanu A, Gherib S, Pini L, Guye M, Ranjeva JP, Varma G, Alsop DC, Pelletier J, Girard OM, Duhamel G. Imaging Neurosci (Camb)20242http://www.ncbi.nlm.nih.gov/pubmed/38880616Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool. Magn Reson Med Sci. 2024 Jul 01; 23(3):352-366.Jaafar N, Alsop DC. Magn Reson Med Sci2024 Jul 0123(3):352-366http://www.ncbi.nlm.nih.gov/pubmed/38788524Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients. Neurobiol Aging. 2024 08; 140:130-139.Cavallari M, Touroutoglou A, Katsumi Y, Fong TG, Schmitt E, Travison TG, Shafi MM, Libermann TA, Marcantonio ER, Alsop DC, Jones RN, Inouye SK, Dickerson BC. Neurobiol Aging2024 08140:130-139http://www.ncbi.nlm.nih.gov/pubmed/38659147Erratum to: Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528-1547). Magn Reson Med. 2024 Aug; 92(2):881.Qin Q, Alsop DC, Bolar DS, Hernandez-Garcia L, Meakin J, Liu D, Nayak KS, Schmid S, van Osch MJP, Wong EC, Woods JG, Zaharchuk G, Zhao MY, Zun Z, Guo J. Magn Reson Med2024 Aug92(2):881http://www.ncbi.nlm.nih.gov/pubmed/38007283Arterial Spin Labeling Perfusion Imaging. Magn Reson Imaging Clin N Am. 2024 Feb; 32(1):63-72.Taso M, Alsop DC. Magn Reson Imaging Clin N Am2024 Feb32(1):63-72http://www.ncbi.nlm.nih.gov/pubmed/37536525Affine image registration of arterial spin labeling MRI using deep learning networks. Neuroimage. 2023 10 01; 279:120303.Zhang Z, Yang H, Guo Y, Bolo NR, Keshavan M, DeRosa E, Anderson AK, Alsop DC, Yin L, Dai W. Neuroimage2023 10 01279:120303http://www.ncbi.nlm.nih.gov/pubmed/37154400Quantitative magnetization transfer MRI unbiased by on-resonance saturation and dipolar order contributions. Magn Reson Med. 2023 09; 90(3):875-893.Soustelle L, Troalen T, Hertanu A, Ranjeva JP, Guye M, Varma G, Alsop DC, Duhamel G, Girard OM. Magn Reson Med2023 0990(3):875-893http://www.ncbi.nlm.nih.gov/pubmed/37125545Levetiracetam Increases Hippocampal Blood Flow in Alzheimer's Disease as Measured by Arterial Spin Labelling MRI. J Alzheimers Dis. 2023; 93(3):939-948.Press DZ, Musaeus CS, Zhao L, Breton JM, Shafi MM, Dai W, Alsop DC. J Alzheimers Dis202393(3):939-948http://www.ncbi.nlm.nih.gov/pubmed/36464096Inhomogeneous Magnetization Transfer (ihMT) imaging in the acute cuprizone mouse model of demyelination/remyelination. Neuroimage. 2023 01; 265:119785.Hertanu A, Soustelle L, Buron J, Le Priellec J, Cayre M, Le Troter A, Prevost VH, Ranjeva JP, Varma G, Alsop DC, Durbec P, Girard OM, Duhamel G. Neuroimage2023 01265:119785http://www.ncbi.nlm.nih.gov/pubmed/36420917Erratum to: Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528-1547). Magn Reson Med. 2023 Mar; 89(3):1278-1279.Qin Q, Alsop DC, Bolar DS, Hernandez-Garcia L, Meakin J, Liu D, Nayak KS, Schmid S, van Osch MJP, Wong EC, Woods JG, Zaharchuk G, Zhao MY, Zun Z, Guo J. Magn Reson Med2023 Mar89(3):1278-1279http://www.ncbi.nlm.nih.gov/pubmed/36306334Fast-spin-echo versus rapid gradient-echo for 3D magnetization-prepared acquisitions: Application to inhomogeneous magnetization transfer. Magn Reson Med. 2023 02; 89(2):550-564.Taso M, Munsch F, Girard OM, Duhamel G, Alsop DC, Varma G. Magn Reson Med2023 0289(2):550-564http://www.ncbi.nlm.nih.gov/pubmed/36068231ASL-BIDS, the brain imaging data structure extension for arterial spin labeling. Sci Data. 2022 09 06; 9(1):543.Clement P, Castellaro M, Okell TW, Thomas DL, Vandemaele P, Elgayar S, Oliver-Taylor A, Kirk T, Woods JG, Vos SB, Kuijer JPA, Achten E, van Osch MJP, Detre JA, Lu H, Alsop DC, Chappell MA, Hernandez-Garcia L, Petr J, Mutsaerts HJMM. Sci Data2022 09 069(1):543http://www.ncbi.nlm.nih.gov/pubmed/36045507The Boston ASL Template and Simulator: Initial development and implementation. J Neuroimaging. 2022 Nov; 32(6):1080-1089.Taso M, Munsch F, Alsop DC. J Neuroimaging2022 Nov32(6):1080-1089http://www.ncbi.nlm.nih.gov/pubmed/36040334Primary Multiparametric Quantitative Brain MRI: State-of-the-Art Relaxometric and Proton Density Mapping Techniques. Radiology. 2022 10; 305(1):5-18.Jara H, Sakai O, Farrher E, Oros-Peusquens AM, Shah NJ, Alsop DC, Keenan KE. Radiology2022 10305(1):5-18http://www.ncbi.nlm.nih.gov/pubmed/35916067Inhomogeneous magnetization transfer imaging: Concepts and directions for further development. NMR Biomed. 2023 06; 36(6):e4808.Alsop DC, Ercan E, Girard OM, Mackay AL, Michal CA, Varma G, Vinogradov E, Duhamel G. NMR Biomed2023 0636(6):e4808http://www.ncbi.nlm.nih.gov/pubmed/35819184Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation. Magn Reson Med. 2022 10; 88(4):1528-1547.Qin Q, Alsop DC, Bolar DS, Hernandez-Garcia L, Meakin J, Liu D, Nayak KS, Schmid S, van Osch MJP, Wong EC, Woods JG, Zaharchuk G, Zhao MY, Zun Z, Guo J. Magn Reson Med2022 1088(4):1528-1547http://www.ncbi.nlm.nih.gov/pubmed/35822100Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging. Brain Commun. 2022; 4(4):fcac163.Katsumi Y, Wong B, Cavallari M, Fong TG, Alsop DC, Andreano JM, Carvalho N, Brickhouse M, Jones R, Libermann TA, Marcantonio ER, Schmitt E, Shafi MM, Pascual-Leone A, Travison T, Barrett LF, Inouye SK, Dickerson BC, Touroutoglou A. Brain Commun20224(4):fcac163http://www.ncbi.nlm.nih.gov/pubmed/35037302T1D -weighted ihMT imaging - Part I. Isolation of long- and short-T1D components by T1D -filtering. Magn Reson Med. 2022 05; 87(5):2313-2328.Hertanu A, Soustelle L, Le Troter A, Buron J, Le Priellec J, Carvalho VND, Cayre M, Durbec P, Varma G, Alsop DC, Girard OM, Duhamel G. Magn Reson Med2022 0587(5):2313-2328http://www.ncbi.nlm.nih.gov/pubmed/35001427T1D -weighted ihMT imaging - Part II. Investigating the long- and short-T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction. Magn Reson Med. 2022 05; 87(5):2329-2346.Hertanu A, Soustelle L, Buron J, Le Priellec J, Cayre M, Le Troter A, Varma G, Alsop DC, Durbec P, Girard OM, Duhamel G. Magn Reson Med2022 0587(5):2329-2346http://www.ncbi.nlm.nih.gov/pubmed/34930421Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease. Alzheimers Res Ther. 2021 12 20; 13(1):203.Sprugnoli G, Munsch F, Cappon D, Paciorek R, Macone J, Connor A, El Fakhri G, Salvador R, Ruffini G, Donohoe K, Shafi MM, Press D, Alsop DC, Pascual Leone A, Santarnecchi E. Alzheimers Res Ther2021 12 2013(1):203http://www.ncbi.nlm.nih.gov/pubmed/34779020A strategy to reduce the sensitivity of inhomogeneous magnetization transfer (ihMT) imaging to radiofrequency transmit field variations at 3 T. Magn Reson Med. 2022 03; 87(3):1346-1359.Soustelle L, Troalen T, Hertanu A, Mchinda S, Ranjeva JP, Guye M, Varma G, Alsop DC, Duhamel G, Girard OM. Magn Reson Med2022 0387(3):1346-1359http://www.ncbi.nlm.nih.gov/pubmed/34297268Priming of Sorafenib Prior to Radiofrequency Ablation Does Not Increase Treatment Effect in Hepatocellular Carcinoma. Dig Dis Sci. 2022 07; 67(7):3455-3463.Bockorny B, Bullock AJ, Abrams TA, Faintuch S, Alsop DC, Goldberg SN, Ahmed M, Miksad RA. Dig Dis Sci2022 0767(7):3455-3463http://www.ncbi.nlm.nih.gov/pubmed/33991697Effects of tDCS dose and electrode montage on regional cerebral blood flow and motor behavior. Neuroimage. 2021 08 15; 237:118144.Shinde AB, Lerud KD, Munsch F, Alsop DC, Schlaug G. Neuroimage2021 08 15237:118144http://www.ncbi.nlm.nih.gov/pubmed/33444098Regional and depth-dependence of cortical blood-flow assessed with high-resolution Arterial Spin Labeling (ASL). J Cereb Blood Flow Metab. 2021 08; 41(8):1899-1911.Taso M, Munsch F, Zhao L, Alsop DC. J Cereb Blood Flow Metab2021 0841(8):1899-1911http://www.ncbi.nlm.nih.gov/pubmed/33258745Arterial Spin Labeled Perfusion MRI for the Evaluation of Response to Tyrosine Kinase Inhibition Therapy in Metastatic Renal Cell Carcinoma. Radiology. 2021 02; 298(2):332-340.Tsai LL, Bhatt RS, Strob MF, Jegede OA, Sun MRM, Alsop DC, Catalano P, McDermott D, Robson PM, Atkins MB, Pedrosa I. Radiology2021 02298(2):332-340http://www.ncbi.nlm.nih.gov/pubmed/33107146Combining inhomogeneous magnetization transfer and multipoint Dixon acquisition: Potential utility and evaluation. Magn Reson Med. 2021 04; 85(4):2136-2144.Ercan E, Varma G, Dimitrov IE, Xi Y, Pinho MC, Yu FF, Zhang S, Wang X, Madhuranthakam AJ, Lenkinski RE, Alsop DC, Vinogradov E. Magn Reson Med2021 0485(4):2136-2144http://www.ncbi.nlm.nih.gov/pubmed/33039620Characterization of the cortical myeloarchitecture with inhomogeneous magnetization transfer imaging (ihMT). Neuroimage. 2021 01 15; 225:117442.Munsch F, Varma G, Taso M, Girard O, Guidon A, Duhamel G, Alsop DC. Neuroimage2021 01 15225:117442http://www.ncbi.nlm.nih.gov/pubmed/32962708Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling. Fluids Barriers CNS. 2020 Sep 22; 17(1):58.Zhao L, Taso M, Dai W, Press DZ, Alsop DC. Fluids Barriers CNS2020 Sep 2217(1):58http://www.ncbi.nlm.nih.gov/pubmed/32931943Rotated spiral RARE for high spatial and temporal resolution volumetric arterial spin labeling acquisition. Neuroimage. 2020 12; 223:117371.Munsch F, Taso M, Zhao L, Lebel RM, Guidon A, Detre JA, Alsop DC. Neuroimage2020 12223:117371http://www.ncbi.nlm.nih.gov/pubmed/32602958Three-dimensional inhomogeneous magnetization transfer with rapid gradient-echo (3D ihMTRAGE) imaging. Magn Reson Med. 2020 12; 84(6):2964-2980.Varma G, Munsch F, Burns B, Duhamel G, Girard OM, Guidon A, Lebel RM, Alsop DC. Magn Reson Med2020 1284(6):2964-2980http://www.ncbi.nlm.nih.gov/pubmed/32250290Older Patients with Alzheimer's Disease-Related Cortical Atrophy Who Develop Post-Operative Delirium May Be at Increased Risk of Long-Term Cognitive Decline After Surgery. J Alzheimers Dis. 2020; 75(1):187-199.Racine AM, Touroutoglou A, Abrantes T, Wong B, Fong TG, Cavallari M, Travison TG, Gou Y, Marcantonio ER, Alsop DC, Jones RN, Inouye SK, Dickerson BC. J Alzheimers Dis202075(1):187-199http://www.ncbi.nlm.nih.gov/pubmed/31887555MRI assessment of multiple dipolar relaxation time (T1D) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model. J Magn Reson. 2020 02; 311:106668.Carvalho VND, Hertanu A, Grélard A, Mchinda S, Soustelle L, Loquet A, Dufourc EJ, Varma G, Alsop DC, Thureau P, Girard OM, Duhamel G. J Magn Reson2020 02311:106668http://www.ncbi.nlm.nih.gov/pubmed/31833014Consensus-based technical recommendations for clinical translation of renal ASL MRI. MAGMA. 2020 Feb; 33(1):141-161.Nery F, Buchanan CE, Harteveld AA, Odudu A, Bane O, Cox EF, Derlin K, Gach HM, Golay X, Gutberlet M, Laustsen C, Ljimani A, Madhuranthakam AJ, Pedrosa I, Prasad PV, Robson PM, Sharma K, Sourbron S, Taso M, Thomas DL, Wang DJJ, Zhang JL, Alsop DC, Fain SB, Francis ST, Fernández-Seara MA. MAGMA2020 Feb33(1):141-161http://www.ncbi.nlm.nih.gov/pubmed/31630476Abnormal perfusion fluctuation and perfusion connectivity in bipolar disorder measured by dynamic arterial spin labeling. Bipolar Disord. 2020 06; 22(4):401-410.Dai W, Chen M, Duan W, Zhao L, Bolo NR, Tamminga C, Clementz BA, Pearlson GD, Alsop DC, Keshavan M. Bipolar Disord2020 0622(4):401-410http://www.ncbi.nlm.nih.gov/pubmed/31628564Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA. MAGMA. 2020 Feb; 33(1):131-140.Mendichovszky I, Pullens P, Dekkers I, Nery F, Bane O, Pohlmann A, de Boer A, Ljimani A, Odudu A, Buchanan C, Sharma K, Laustsen C, Harteveld A, Golay X, Pedrosa I, Alsop D, Fain S, Caroli A, Prasad P, Francis S, Sigmund E, Fernández-Seara M, Sourbron S. MAGMA2020 Feb33(1):131-140http://www.ncbi.nlm.nih.gov/pubmed/31166241Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 09; 131(3):477-491.Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R. Anesthesiology2019 09131(3):477-491http://www.ncbi.nlm.nih.gov/pubmed/31410924Pancreatic perfusion modulation following glucose stimulation assessed by noninvasive arterial spin labeling (ASL) MRI. J Magn Reson Imaging. 2020 03; 51(3):854-860.Taso M, Papadopoulou F, Smith MP, Tsai LL, Mortele KJ, Alsop DC. J Magn Reson Imaging2020 0351(3):854-860http://www.ncbi.nlm.nih.gov/pubmed/31141736Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy. Neuroimage. 2019 10 01; 199:289-303.Duhamel G, Prevost VH, Cayre M, Hertanu A, Mchinda S, Carvalho VN, Varma G, Durbec P, Alsop DC, Girard OM. Neuroimage2019 10 01199:289-303http://www.ncbi.nlm.nih.gov/pubmed/30953396Volumetric abdominal perfusion measurement using a pseudo-randomly sampled 3D fast-spin-echo (FSE) arterial spin labeling (ASL) sequence and compressed sensing reconstruction. Magn Reson Med. 2019 08; 82(2):680-692.Taso M, Zhao L, Guidon A, Litwiller DV, Alsop DC. Magn Reson Med2019 0882(2):680-692http://www.ncbi.nlm.nih.gov/pubmed/30787172Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition. Mol Cancer Ther. 2019 04; 18(4):856-867.Fischl AS, Wang X, Falcon BL, Almonte-Baldonado R, Bodenmiller D, Evans G, Stewart J, Wilson T, Hipskind P, Manro J, Uhlik MT, Chintharlapalli S, Gerald D, Alsop DC, Benjamin LE, Bhatt RS. Mol Cancer Ther2019 0418(4):856-867http://www.ncbi.nlm.nih.gov/pubmed/29529166Development of a Dynamic Multi-Protein Signature of Postoperative Delirium. J Gerontol A Biol Sci Med Sci. 2019 01 16; 74(2):261-268.Vasunilashorn SM, Ngo LH, Chan NY, Zhou W, Dillon ST, Otu HH, Inouye SK, Wyrobnik I, Kuchel GA, McElhaney JE, Xie Z, Alsop DC, Jones RN, Libermann TA, Marcantonio ER. J Gerontol A Biol Sci Med Sci2019 01 1674(2):261-268http://www.ncbi.nlm.nih.gov/pubmed/30474312Influence of background suppression and retrospective realignment on free-breathing renal perfusion measurement using pseudo-continuous ASL. Magn Reson Med. 2019 04; 81(4):2439-2449.Taso M, Guidon A, Alsop DC. Magn Reson Med2019 0481(4):2439-2449http://www.ncbi.nlm.nih.gov/pubmed/30229559Pancreatic perfusion and arterial-transit-time quantification using pseudocontinuous arterial spin labeling at 3T. Magn Reson Med. 2019 01; 81(1):542-550.Taso M, Guidon A, Zhao L, Mortele KJ, Alsop DC. Magn Reson Med2019 0181(1):542-550http://www.ncbi.nlm.nih.gov/pubmed/30212729Low duty-cycle pulsed irradiation reduces magnetization transfer and increases the inhomogeneous magnetization transfer effect. J Magn Reson. 2018 11; 296:60-71.Varma G, Girard OM, Mchinda S, Prevost VH, Grant AK, Duhamel G, Alsop DC. J Magn Reson2018 11296:60-71http://www.ncbi.nlm.nih.gov/pubmed/29707813Microstructural correlates of 3D steady-state inhomogeneous magnetization transfer (ihMT) in the human brain white matter assessed by myelin water imaging and diffusion tensor imaging. Magn Reson Med. 2018 Dec; 80(6):2402-2414.Ercan E, Varma G, Mädler B, Dimitrov IE, Pinho MC, Xi Y, Wagner BC, Davenport EM, Maldjian JA, Alsop DC, Lenkinski RE, Vinogradov E. Magn Reson Med2018 Dec80(6):2402-2414http://www.ncbi.nlm.nih.gov/pubmed/29472299Evaluation of the Sensitivity of Inhomogeneous Magnetization Transfer (ihMT) MRI for Multiple Sclerosis. AJNR Am J Neuroradiol. 2018 Apr; 39(4):634-641.Van Obberghen E, Mchinda S, le Troter A, Prevost VH, Viout P, Guye M, Varma G, Alsop DC, Ranjeva JP, Pelletier J, Girard O, Duhamel G. AJNR Am J Neuroradiol2018 Apr39(4):634-641http://www.ncbi.nlm.nih.gov/pubmed/29454933Effects of resting state condition on reliability, trait specificity, and network connectivity of brain function measured with arterial spin labeled perfusion MRI. Neuroimage. 2018 06; 173:165-175.Li Z, Vidorreta M, Katchmar N, Alsop DC, Wolf DH, Detre JA. Neuroimage2018 06173:165-175http://www.ncbi.nlm.nih.gov/pubmed/29427325Controlling T2 blurring in 3D RARE arterial spin labeling acquisition through optimal combination of variable flip angles and k-space filtering. Magn Reson Med. 2018 10; 80(4):1391-1401.Zhao L, Chang CD, Alsop DC. Magn Reson Med2018 1080(4):1391-1401http://www.ncbi.nlm.nih.gov/pubmed/28940355Whole brain inhomogeneous magnetization transfer (ihMT) imaging: Sensitivity enhancement within a steady-state gradient echo sequence. Magn Reson Med. 2018 05; 79(5):2607-2619.Mchinda S, Varma G, Prevost VH, Le Troter A, Rapacchi S, Guye M, Pelletier J, Ranjeva JP, Alsop DC, Duhamel G, Girard OM. Magn Reson Med2018 0579(5):2607-2619http://www.ncbi.nlm.nih.gov/pubmed/28916179A comparison of inhomogeneous magnetization transfer, myelin volume fraction, and diffusion tensor imaging measures in healthy children. Neuroimage. 2018 11 15; 182:343-350.Geeraert BL, Lebel RM, Mah AC, Deoni SC, Alsop DC, Varma G, Lebel C. Neuroimage2018 11 15182:343-350http://www.ncbi.nlm.nih.gov/pubmed/28816098Global fluctuations of cerebral blood flow indicate a global brain network independent of systemic factors. J Cereb Blood Flow Metab. 2019 02; 39(2):302-312.Zhao L, Alsop DC, Detre JA, Dai W. J Cereb Blood Flow Metab2019 0239(2):302-312http://www.ncbi.nlm.nih.gov/pubmed/28796542Cine MRI of Tracheal Dynamics in Healthy Volunteers and Patients With Tracheobronchomalacia. AJR Am J Roentgenol. 2017 Oct; 209(4):757-761.Ciet P, Boiselle PM, Heidinger B, Andrinopoulou ER, O'Donnel C, Alsop DC, Litmanovich DE. AJR Am J Roentgenol2017 Oct209(4):757-761http://www.ncbi.nlm.nih.gov/pubmed/28779010Longitudinal diffusion changes following postoperative delirium in older people without dementia. Neurology. 2017 Sep 05; 89(10):1020-1027.Cavallari M, Dai W, Guttmann CRG, Meier DS, Ngo LH, Hshieh TT, Fong TG, Schmitt E, Press DZ, Travison TG, Marcantonio ER, Jones RN, Inouye SK, Alsop DC. Neurology2017 Sep 0589(10):1020-1027http://www.ncbi.nlm.nih.gov/pubmed/28846882Alzheimer's-related cortical atrophy is associated with postoperative delirium severity in persons without dementia. Neurobiol Aging. 2017 11; 59:55-63.Racine AM, Fong TG, Travison TG, Jones RN, Gou Y, Vasunilashorn SM, Marcantonio ER, Alsop DC, Inouye SK, Dickerson BC. Neurobiol Aging2017 1159:55-63http://www.ncbi.nlm.nih.gov/pubmed/28802800State of the Art and Promise of Structural Neuroimaging in Postoperative Delirium and Postoperative Cognitive Decline. Am J Geriatr Psychiatry. 2017 10; 25(10):1062-1063.Cavallari M, Guttmann CRG, Inouye SK, Alsop DC. Am J Geriatr Psychiatry2017 1025(10):1062-1063http://www.ncbi.nlm.nih.gov/pubmed/28587598Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium. BMC Med Res Methodol. 2017 Jun 06; 17(1):88.Ngo LH, Inouye SK, Jones RN, Travison TG, Libermann TA, Dillon ST, Kuchel GA, Vasunilashorn SM, Alsop DC, Marcantonio ER. BMC Med Res Methodol2017 Jun 0617(1):88http://www.ncbi.nlm.nih.gov/pubmed/28555781High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery. J Am Geriatr Soc. 2017 Aug; 65(8):e109-e116.Vasunilashorn SM, Dillon ST, Inouye SK, Ngo LH, Fong TG, Jones RN, Travison TG, Schmitt EM, Alsop DC, Freedman SD, Arnold SE, Metzger ED, Libermann TA, Marcantonio ER. J Am Geriatr Soc2017 Aug65(8):e109-e116http://www.ncbi.nlm.nih.gov/pubmed/28195663Optimization of inhomogeneous magnetization transfer (ihMT) MRI contrast for preclinical studies using dipolar relaxation time (T1D ) filtering. NMR Biomed. 2017 Jun; 30(6).Prevost VH, Girard OM, Mchinda S, Varma G, Alsop DC, Duhamel G. NMR Biomed2017 Jun30(6)http://www.ncbi.nlm.nih.gov/pubmed/27898172Association Between Hospital Readmission and Acute and Sustained Delays in Functional Recovery During 18 Months After Elective Surgery: The Successful Aging after Elective Surgery Study. J Am Geriatr Soc. 2017 01; 65(1):51-58.Pisani MA, Albuquerque A, Marcantonio ER, Jones RN, Gou RY, Fong TG, Schmitt EM, Tommet D, Isaza Aizpurua II, Alsop DC, Inouye SK, Travison TG. J Am Geriatr Soc2017 0165(1):51-58http://www.ncbi.nlm.nih.gov/pubmed/27876012Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas. BMC Cancer. 2016 11 22; 16(1):914.Wong ET, Timmons J, Callahan A, O'Loughlin L, Giarusso B, Alsop DC. BMC Cancer2016 11 2216(1):914http://www.ncbi.nlm.nih.gov/pubmed/27859618In vivo measurement of a new source of contrast, the dipolar relaxation time, T1D , using a modified inhomogeneous magnetization transfer (ihMT) sequence. Magn Reson Med. 2017 10; 78(4):1362-1372.Varma G, Girard OM, Prevost VH, Grant AK, Duhamel G, Alsop DC. Magn Reson Med2017 1078(4):1362-1372http://www.ncbi.nlm.nih.gov/pubmed/27774656Improving the robustness of pseudo-continuous arterial spin labeling to off-resonance and pulsatile flow velocity. Magn Reson Med. 2017 10; 78(4):1342-1351.Zhao L, Vidorreta M, Soman S, Detre JA, Alsop DC. Magn Reson Med2017 1078(4):1342-1351http://www.ncbi.nlm.nih.gov/pubmed/27761677Tissue recovery practices and bioburden: a systematic review. Cell Tissue Bank. 2016 Dec; 17(4):561-571.Brubaker S, Lotherington K, Zhao J, Hamilton B, Rockl G, Duong A, Garibaldi A, Simunovic N, Alsop D, Dao D, Bessemer R, Ayeni OR. Cell Tissue Bank2016 Dec17(4):561-571http://www.ncbi.nlm.nih.gov/pubmed/27723582Using Anatomic Magnetic Resonance Image Information to Enhance Visualization and Interpretation of Functional Images: A Comparison of Methods Applied to Clinical Arterial Spin Labeling Images. IEEE Trans Med Imaging. 2017 02; 36(2):487-496.Zhao L, Dai W, Soman S, Hackney DB, Wong ET, Robson PM, Alsop DC. IEEE Trans Med Imaging2017 0236(2):487-496http://www.ncbi.nlm.nih.gov/pubmed/27665294Disinfection of human musculoskeletal allografts in tissue banking: a systematic review. Cell Tissue Bank. 2016 Dec; 17(4):573-584.Mohr J, Germain M, Winters M, Fraser S, Duong A, Garibaldi A, Simunovic N, Alsop D, Dao D, Bessemer R, Ayeni OR. Cell Tissue Bank2016 Dec17(4):573-584http://www.ncbi.nlm.nih.gov/pubmed/27647793Preoperative Cognitive Performance Dominates Risk for Delirium Among Older Adults. J Geriatr Psychiatry Neurol. 2016 Nov; 29(6):320-327.Jones RN, Marcantonio ER, Saczynski JS, Tommet D, Gross AL, Travison TG, Alsop DC, Schmitt EM, Fong TG, Cizginer S, Shafi MM, Pascual-Leone A, Inouye SK. J Geriatr Psychiatry Neurol2016 Nov29(6):320-327http://www.ncbi.nlm.nih.gov/pubmed/27472845Modulating transcallosal and intra-hemispheric brain connectivity with tDCS: Implications for interventions in Aphasia. Restor Neurol Neurosci. 2016 07 25; 34(4):519-30.Zheng X, Dai W, Alsop DC, Schlaug G. Restor Neurol Neurosci2016 07 2534(4):519-30http://www.ncbi.nlm.nih.gov/pubmed/27384230Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort. J Magn Reson Imaging. 2017 02; 45(2):472-481.Dai W, Fong T, Jones RN, Marcantonio E, Schmitt E, Inouye SK, Alsop DC. J Magn Reson Imaging2017 0245(2):472-481http://www.ncbi.nlm.nih.gov/pubmed/27248821Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma. Oncotarget. 2016 Jul 05; 7(27):41857-41869.Wang X, Solban N, Khanna P, Callea M, Song J, Alsop DC, Pearsall RS, Atkins MB, Mier JW, Signoretti S, Alimzhanov M, Kumar R, Bhasin MK, Bhatt RS. Oncotarget2016 Jul 057(27):41857-41869http://www.ncbi.nlm.nih.gov/pubmed/27343260Reply: Neural substrates of vulnerability to post-surgical delirium with prospective diagnosis. Brain. 2016 Oct; 139(Pt 10):e55.Cavallari M, Guttmann CR, Jones RN, Inouye SK, Alsop DC. Brain2016 Oct139(Pt 10):e55http://www.ncbi.nlm.nih.gov/pubmed/27103261The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement. 2016 07; 12(7):766-75.Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, Saczynski JS, Ngo LH, Alsop DC, Jones RN. Alzheimers Dement2016 0712(7):766-75http://www.ncbi.nlm.nih.gov/pubmed/27160518Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study. Biol Psychiatry. 2017 01 15; 81(2):145-153.Dillon ST, Vasunilashorn SM, Ngo L, Otu HH, Inouye SK, Jones RN, Alsop DC, Kuchel GA, Metzger ED, Arnold SE, Marcantonio ER, Libermann TA. Biol Psychiatry2017 01 1581(2):145-153http://www.ncbi.nlm.nih.gov/pubmed/26959278Magnetization transfer from inhomogeneously broadened lines (ihMT): Improved imaging strategy for spinal cord applications. Magn Reson Med. 2017 02; 77(2):581-591.Girard OM, Callot V, Prevost VH, Robert B, Taso M, Ribeiro G, Varma G, Rangwala N, Alsop DC, Duhamel G. Magn Reson Med2017 0277(2):581-591http://www.ncbi.nlm.nih.gov/pubmed/26920674Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016 Apr; 139(Pt 4):1282-94.Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC. Brain2016 Apr139(Pt 4):1282-94http://www.ncbi.nlm.nih.gov/pubmed/26762244Minimizing the effects of magnetization transfer asymmetry on inhomogeneous magnetization transfer (ihMT) at ultra-high magnetic field (11.75 T). MAGMA. 2016 Aug; 29(4):699-709.Prevost VH, Girard OM, Varma G, Alsop DC, Duhamel G. MAGMA2016 Aug29(4):699-709http://www.ncbi.nlm.nih.gov/pubmed/27401806Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1386-1397.Hshieh TT, Dai W, Cavallari M, Guttmann CR, Meier DS, Schmitt EM, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Gou YR, Travison TG, Fong TG, Ngo L, Inouye SK, Alsop DC. J Cereb Blood Flow Metab2017 Apr37(4):1386-1397http://www.ncbi.nlm.nih.gov/pubmed/26631180Head circumference as a useful surrogate for intracranial volume in older adults. Int Psychogeriatr. 2016 Jan; 28(1):157-62.Hshieh TT, Fox ML, Kosar CM, Cavallari M, Guttmann CR, Alsop D, Marcantonio ER, Schmitt EM, Jones RN, Inouye SK. Int Psychogeriatr2016 Jan28(1):157-62http://www.ncbi.nlm.nih.gov/pubmed/26662213The Successful Aging after Elective Surgery (SAGES) Study: Cohort Description and Data Quality Procedures. J Am Geriatr Soc. 2015 Dec; 63(12):2463-2471.Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Marcantonio ER, Travison T, Inouye SK. J Am Geriatr Soc2015 Dec63(12):2463-2471http://www.ncbi.nlm.nih.gov/pubmed/26661226Quantifying fluctuations of resting state networks using arterial spin labeling perfusion MRI. J Cereb Blood Flow Metab. 2016 Mar; 36(3):463-73.Dai W, Varma G, Scheidegger R, Alsop DC. J Cereb Blood Flow Metab2016 Mar36(3):463-73http://www.ncbi.nlm.nih.gov/pubmed/26521186Volumetric Arterial Spin-labeled Perfusion Imaging of the Kidneys with a Three-dimensional Fast Spin Echo Acquisition. Acad Radiol. 2016 Feb; 23(2):144-54.Robson PM, Madhuranthakam AJ, Smith MP, Sun MR, Dai W, Rofsky NM, Pedrosa I, Alsop DC. Acad Radiol2016 Feb23(2):144-54http://www.ncbi.nlm.nih.gov/pubmed/26507361Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP. Magn Reson Med. 2016 10; 76(4):1102-15.Varma G, Wang X, Vinogradov E, Bhatt RS, Sukhatme VP, Seth P, Lenkinski RE, Alsop DC, Grant AK. Magn Reson Med2016 1076(4):1102-15http://www.ncbi.nlm.nih.gov/pubmed/26408956Interpretation of magnetization transfer from inhomogeneously broadened lines (ihMT) in tissues as a dipolar order effect within motion restricted molecules. J Magn Reson. 2015 Nov; 260:67-76.Varma G, Girard OM, Prevost VH, Grant AK, Duhamel G, Alsop DC. J Magn Reson2015 Nov260:67-76http://www.ncbi.nlm.nih.gov/pubmed/26215633Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery. J Gerontol A Biol Sci Med Sci. 2015 Oct; 70(10):1289-95.Vasunilashorn SM, Ngo L, Inouye SK, Libermann TA, Jones RN, Alsop DC, Guess J, Jastrzebski S, McElhaney JE, Kuchel GA, Marcantonio ER. J Gerontol A Biol Sci Med Sci2015 Oct70(10):1289-95http://www.ncbi.nlm.nih.gov/pubmed/25824618Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia. Neurobiol Aging. 2015 Jun; 36(6):2122-9.Cavallari M, Hshieh TT, Guttmann CR, Ngo LH, Meier DS, Schmitt EM, Marcantonio ER, Jones RN, Kosar CM, Fong TG, Press D, Inouye SK, Alsop DC. Neurobiol Aging2015 Jun36(6):2122-9http://www.ncbi.nlm.nih.gov/pubmed/25589614Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. Clin Cancer Res. 2015 Apr 15; 21(8):1925-1934.Zhang L, Wang X, Bullock AJ, Callea M, Shah H, Song J, Moreno K, Visentin B, Deutschman D, Alsop DC, Atkins MB, Mier JW, Signoretti S, Bhasin M, Sabbadini RA, Bhatt RS. Clin Cancer Res2015 Apr 1521(8):1925-1934http://www.ncbi.nlm.nih.gov/pubmed/26510993Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med. 2015 Jan; 73(1):spcone.Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, MacIntosh BJ, Parkes LM, Smits M, van Osch MJ, Wang DJ, Wong EC, Zaharchuk G. Magn Reson Med2015 Jan73(1):spconehttp://www.ncbi.nlm.nih.gov/pubmed/26361198Cognitive and brain reserve and the risk of postoperative delirium in older patients: analysis of data from a prospective observational study. Lancet Psychiatry. 2014 Nov; 1(6):437-43.Saczynski JS, Inouye SK, Kosar CM, Tommet D, Marcantonio ER, Fong T, Hshieh T, Vasunilashorn S, Metzger ED, Schmitt E, Alsop DC, Jones RN. Lancet Psychiatry2014 Nov1(6):437-43http://www.ncbi.nlm.nih.gov/pubmed/25642414Cognitive and brain reserve and the risk of postoperative delirium in older patients: analysis of data from a prospective observational study. Lancet Psychiatry. 2014 11; 1(6):437-443.Saczynski JS, Inouye SK, Kosar C, Tommet D, Marcantonio ER, Fong T, Hshieh T, Vasunilashorn S, Metzger ED, Schmitt E, Alsop DC, Jones RN. Lancet Psychiatry2014 111(6):437-443http://www.ncbi.nlm.nih.gov/pubmed/24962257Magnetization transfer from inhomogeneously broadened lines (ihMT): Experimental optimization of saturation parameters for human brain imaging at 1.5 Tesla. Magn Reson Med. 2015 Jun; 73(6):2111-21.Girard OM, Prevost VH, Varma G, Cozzone PJ, Alsop DC, Duhamel G. Magn Reson Med2015 Jun73(6):2111-21http://www.ncbi.nlm.nih.gov/pubmed/24857712Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3 Tesla. Neuroimage. 2014 Oct 01; 99:256-68.Scheidegger R, Wong ET, Alsop DC. Neuroimage2014 Oct 0199:256-68http://www.ncbi.nlm.nih.gov/pubmed/24752885Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014 May; 75(5):659-69.Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Ann Neurol2014 May75(5):659-69http://www.ncbi.nlm.nih.gov/pubmed/24715426Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med. 2015 Jan; 73(1):102-16.Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, MacIntosh BJ, Parkes LM, Smits M, van Osch MJ, Wang DJ, Wong EC, Zaharchuk G. Magn Reson Med2015 Jan73(1):102-16http://www.ncbi.nlm.nih.gov/pubmed/24604578Magnetization transfer from inhomogeneously broadened lines: A potential marker for myelin. Magn Reson Med. 2015 Feb; 73(2):614-22.Varma G, Duhamel G, de Bazelaire C, Alsop DC. Magn Reson Med2015 Feb73(2):614-22http://www.ncbi.nlm.nih.gov/pubmed/24704536The role of angiopoietins as potential therapeutic targets in renal cell carcinoma. Transl Oncol. 2014 Apr; 7(2):188-95.Wang X, Bullock AJ, Zhang L, Wei L, Yu D, Mahagaokar K, Alsop DC, Mier JW, Atkins MB, Coxon A, Oliner J, Bhatt RS. Transl Oncol2014 Apr7(2):188-95http://www.ncbi.nlm.nih.gov/pubmed/24442797Three-dimensional brain MRI for DBS patients within ultra-low radiofrequency power limits. Mov Disord. 2014 Apr; 29(4):546-9.Sarkar SN, Papavassiliou E, Hackney DB, Alsop DC, Shih LC, Madhuranthakam AJ, Busse RF, La Ruche S, Bhadelia RA. Mov Disord2014 Apr29(4):546-9http://www.ncbi.nlm.nih.gov/pubmed/24088807Hyperperfusion in progressive multifocal leukoencephalopathy is associated with disease progression and absence of immune reconstitution inflammatory syndrome. Brain. 2013 Nov; 136(Pt 11):3441-50.Khoury MN, Gheuens S, Ngo L, Wang X, Alsop DC, Koralnik IJ. Brain2013 Nov136(Pt 11):3441-50http://www.ncbi.nlm.nih.gov/pubmed/24052241Improved short tau inversion recovery (iSTIR) for increased tumor conspicuity in the abdomen. MAGMA. 2014 Jun; 27(3):245-55.Madhuranthakam AJ, Lee KS, Yassin A, Brittain JH, Pedrosa I, Rofsky NM, Alsop DC. MAGMA2014 Jun27(3):245-55http://www.ncbi.nlm.nih.gov/pubmed/23803881Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr. 2013 Sep; 98(3):641-7.Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Am J Clin Nutr2013 Sep98(3):641-7http://www.ncbi.nlm.nih.gov/pubmed/23771644Physiological and psychological individual differences influence resting brain function measured by ASL perfusion. Brain Struct Funct. 2014 Sep; 219(5):1673-84.Kano M, Coen SJ, Farmer AD, Aziz Q, Williams SC, Alsop DC, Fukudo S, O'Gorman RL. Brain Struct Funct2014 Sep219(5):1673-84http://www.ncbi.nlm.nih.gov/pubmed/23747289Diffusion restriction in the human spinal cord characterized in vivo with high b-value STEAM diffusion imaging. Neuroimage. 2013 Nov 15; 82:416-25.Rangwala NA, Hackney DB, Dai W, Alsop DC. Neuroimage2013 Nov 1582:416-25http://www.ncbi.nlm.nih.gov/pubmed/23587427A selective insular perfusion deficit contributes to compromised salience network connectivity in recovering alcoholic men. Biol Psychiatry. 2013 Oct 01; 74(7):547-55.Sullivan EV, Müller-Oehring E, Pitel AL, Chanraud S, Shankaranarayanan A, Alsop DC, Rohlfing T, Pfefferbaum A. Biol Psychiatry2013 Oct 0174(7):547-55http://www.ncbi.nlm.nih.gov/pubmed/23499791Resting-state cerebral blood flow in amygdala is modulated by sex and serotonin transporter genotype. Neuroimage. 2013 Aug 01; 76:90-7.El-Hage W, Zelaya F, Radua J, Gohier B, Alsop DC, Phillips ML, Surguladze SA. Neuroimage2013 Aug 0176:90-7http://www.ncbi.nlm.nih.gov/pubmed/28136892Inhibition of tumor growth in a VEGFR TKI-resistant model of renal cell carcinoma using dalantercept combined with sunitinib. J Clin Oncol. 2013 Feb 20; 31(6_suppl):370.Wang X, Solban N, Wei L, Signoretti S, Alsop D, Alimzhanov M, Pearsall S, Atkins MB, Kumar R, Sherman ML, Mier JW. J Clin Oncol2013 Feb 2031(6_suppl):370http://www.ncbi.nlm.nih.gov/pubmed/23322198Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. Br J Cancer. 2013 Feb 05; 108(2):319-26.Wang X, Zhang L, O'Neill A, Bahamon B, Alsop DC, Mier JW, Goldberg SN, Signoretti S, Atkins MB, Wood CG, Bhatt RS. Br J Cancer2013 Feb 05108(2):319-26http://www.ncbi.nlm.nih.gov/pubmed/23160910Coupling between resting cerebral perfusion and EEG. Brain Topogr. 2013 Jul; 26(3):442-57.O'Gorman RL, Poil SS, Brandeis D, Klaver P, Bollmann S, Ghisleni C, Lüchinger R, Martin E, Shankaranarayanan A, Alsop DC, Michels L. Brain Topogr2013 Jul26(3):442-57http://www.ncbi.nlm.nih.gov/pubmed/23047841Arterial spin-labeling MR imaging of renal masses: correlation with histopathologic findings. Radiology. 2012 Dec; 265(3):799-808.Lanzman RS, Robson PM, Sun MR, Patel AD, Mentore K, Wagner AA, Genega EM, Rofsky NM, Alsop DC, Pedrosa I. Radiology2012 Dec265(3):799-808http://www.ncbi.nlm.nih.gov/pubmed/22175654Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study. Curr Alzheimer Res. 2012 Oct; 9(8):990-7.Carlsson CM, Xu G, Wen Z, Barnet JH, Blazel HM, Chappell RJ, Stein JH, Asthana S, Sager MA, Alsop DC, Rowley HA, Fain SB, Johnson SC. Curr Alzheimer Res2012 Oct9(8):990-7http://www.ncbi.nlm.nih.gov/pubmed/22999782Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods. J Am Med Dir Assoc. 2012 Nov; 13(9):818.e1-10.Schmitt EM, Marcantonio ER, Alsop DC, Jones RN, Rogers SO, Fong TG, Metzger E, Inouye SK. J Am Med Dir Assoc2012 Nov13(9):818.e1-10http://www.ncbi.nlm.nih.gov/pubmed/22914832Metabolic profile of PML lesions in patients with and without IRIS: an observational study. Neurology. 2012 Sep 04; 79(10):1041-8.Gheuens S, Ngo L, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Neurology2012 Sep 0479(10):1041-8http://www.ncbi.nlm.nih.gov/pubmed/22892333A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. Neuroimage. 2012 Nov 15; 63(3):1510-8.Pienaar R, Paldino MJ, Madan N, Krishnamoorthy KS, Alsop DC, Dehaes M, Grant PE. Neuroimage2012 Nov 1563(3):1510-8http://www.ncbi.nlm.nih.gov/pubmed/22618894Volumetric measurement of perfusion and arterial transit delay using hadamard encoded continuous arterial spin labeling. Magn Reson Med. 2013 Apr; 69(4):1014-22.Dai W, Shankaranarayanan A, Alsop DC. Magn Reson Med2013 Apr69(4):1014-22http://www.ncbi.nlm.nih.gov/pubmed/22517104Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS. Neurology. 2012 May 01; 78(18):1390-3.Gheuens S, Smith DR, Wang X, Alsop DC, Lenkinski RE, Koralnik IJ. Neurology2012 May 0178(18):1390-3http://www.ncbi.nlm.nih.gov/pubmed/22427138Arterial spin labeling: its time is now. MAGMA. 2012 Apr; 25(2):75-7.Alsop DC. MAGMA2012 Apr25(2):75-7http://www.ncbi.nlm.nih.gov/pubmed/22451196Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain. Hum Brain Mapp. 2013 Feb; 34(2):272-82.Handley R, Zelaya FO, Reinders AA, Marques TR, Mehta MA, O'Gorman R, Alsop DC, Taylor H, Johnston A, Williams S, McGuire P, Pariante CM, Kapur S, Dazzan P. Hum Brain Mapp2013 Feb34(2):272-82http://www.ncbi.nlm.nih.gov/pubmed/22348885Differentiating maturational and training influences on fMRI activation during music processing. Neuroimage. 2012 Apr 15; 60(3):1902-12.Ellis RJ, Norton AC, Overy K, Winner E, Alsop DC, Schlaug G. Neuroimage2012 Apr 1560(3):1902-12http://www.ncbi.nlm.nih.gov/pubmed/22266414Dissociable effects of methylphenidate, atomoxetine and placebo on regional cerebral blood flow in healthy volunteers at rest: a multi-class pattern recognition approach. Neuroimage. 2012 Apr 02; 60(2):1015-24.Marquand AF, O'Daly OG, De Simoni S, Alsop DC, Maguire RP, Williams SC, Zelaya FO, Mehta MA. Neuroimage2012 Apr 0260(2):1015-24http://www.ncbi.nlm.nih.gov/pubmed/22188900High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma. J Transl Med. 2011 Dec 21; 9:220.Wang X, Zhang L, Goldberg SN, Bhasin M, Brown V, Alsop DC, Signoretti S, Mier JW, Atkins MB, Bhatt RS. J Transl Med2011 Dec 219:220http://www.ncbi.nlm.nih.gov/pubmed/22084006Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging. Magn Reson Med. 2012 May; 67(5):1252-65.Dai W, Robson PM, Shankaranarayanan A, Alsop DC. Magn Reson Med2012 May67(5):1252-65http://www.ncbi.nlm.nih.gov/pubmed/22027578Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition. J Hepatol. 2012 Mar; 56(3):549-56.Byrnes V, Miller A, Lowry D, Hill E, Weinstein C, Alsop D, Lenkinski R, Afdhal NH. J Hepatol2012 Mar56(3):549-56http://www.ncbi.nlm.nih.gov/pubmed/22009131Optimization of background suppression for arterial spin labeling perfusion imaging. MAGMA. 2012 Apr; 25(2):127-33.Maleki N, Dai W, Alsop DC. MAGMA2012 Apr25(2):127-33http://www.ncbi.nlm.nih.gov/pubmed/22012707Pseudo-continuous arterial spin labeling at very high magnetic field (11.75 T) for high-resolution mouse brain perfusion imaging. Magn Reson Med. 2012 May; 67(5):1225-36.Duhamel G, Callot V, Tachrount M, Alsop DC, Cozzone PJ. Magn Reson Med2012 May67(5):1225-36http://www.ncbi.nlm.nih.gov/pubmed/21926285Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care. 2011 Nov; 34(11):2438-41.Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P. Diabetes Care2011 Nov34(11):2438-41http://www.ncbi.nlm.nih.gov/pubmed/21877173Arterial spin labeling MR imaging for characterisation of renal masses in patients with impaired renal function: initial experience. Eur Radiol. 2012 Feb; 22(2):484-92.Pedrosa I, Rafatzand K, Robson P, Wagner AA, Atkins MB, Rofsky NM, Alsop DC. Eur Radiol2012 Feb22(2):484-92http://www.ncbi.nlm.nih.gov/pubmed/21447683The effect of hypercarbia and hyperoxia on the total blood flow to the retina as assessed by magnetic resonance imaging. Invest Ophthalmol Vis Sci. 2011 Aug 29; 52(9):6867-74.Maleki N, Alsop DC, Dai W, Hudson C, Han JS, Fisher J, Mikulis D. Invest Ophthalmol Vis Sci2011 Aug 2952(9):6867-74http://www.ncbi.nlm.nih.gov/pubmed/21703350Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow. Neuroimage. 2011 Sep 01; 58(1):26-33.Zheng X, Alsop DC, Schlaug G. Neuroimage2011 Sep 0158(1):26-33http://www.ncbi.nlm.nih.gov/pubmed/21608029Amide proton transfer imaging with improved robustness to magnetic field inhomogeneity and magnetization transfer asymmetry using saturation with frequency alternating RF irradiation. Magn Reson Med. 2011 Nov; 66(5):1275-85.Scheidegger R, Vinogradov E, Alsop DC. Magn Reson Med2011 Nov66(5):1275-85http://www.ncbi.nlm.nih.gov/pubmed/21590725Optimized double inversion recovery for reduction of T1 weighting in fluid-attenuated inversion recovery. Magn Reson Med. 2012 Jan; 67(1):81-8.Madhuranthakam AJ, Sarkar SN, Busse RF, Bakshi R, Alsop DC. Magn Reson Med2012 Jan67(1):81-8http://www.ncbi.nlm.nih.gov/pubmed/21559452Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression. PLoS One. 2011 Apr 29; 6(4):e19144.Zhang L, Bhasin M, Schor-Bardach R, Wang X, Collins MP, Panka D, Putheti P, Signoretti S, Alsop DC, Libermann T, Atkins MB, Mier JW, Goldberg SN, Bhatt RS. PLoS One2011 Apr 296(4):e19144http://www.ncbi.nlm.nih.gov/pubmed/21527570A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1138-42.Klein JP, Arora A, Neema M, Healy BC, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Stankiewicz JM, Cohen AB, Buckle GJ, Houtchens MK, Ceccarelli A, Dell'Oglio E, Guttmann CR, Alsop DC, Hackney DB, Bakshi R. AJNR Am J Neuroradiol2011 Jun-Jul32(6):1138-42http://www.ncbi.nlm.nih.gov/pubmed/21523824Sensitivity calibration with a uniform magnetization image to improve arterial spin labeling perfusion quantification. Magn Reson Med. 2011 Dec; 66(6):1590-600.Dai W, Robson PM, Shankaranarayanan A, Alsop DC. Magn Reson Med2011 Dec66(6):1590-600http://www.ncbi.nlm.nih.gov/pubmed/21447024The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):122-8.Cohen AB, Neema M, Arora A, Dell'oglio E, Benedict RH, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Ceccarelli A, Klein JP, Stankiewicz JM, Houtchens MK, Buckle GJ, Alsop DC, Guttmann CR, Bakshi R. J Neuroimaging2012 Apr22(2):122-8http://www.ncbi.nlm.nih.gov/pubmed/21432901Perfusion imaging with a freely diffusible hyperpolarized contrast agent. Magn Reson Med. 2011 Sep; 66(3):746-55.Grant AK, Vinogradov E, Wang X, Lenkinski RE, Alsop DC. Magn Reson Med2011 Sep66(3):746-55http://www.ncbi.nlm.nih.gov/pubmed/20924800Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction? Brain Imaging Behav. 2011 Mar; 5(1):25-35.Fong TG, Inouye SK, Dai W, Press DZ, Alsop DC. Brain Imaging Behav2011 Mar5(1):25-35http://www.ncbi.nlm.nih.gov/pubmed/21357520Brain MR imaging at ultra-low radiofrequency power. Radiology. 2011 May; 259(2):550-7.Sarkar SN, Alsop DC, Madhuranthakam AJ, Busse RF, Robson PM, Rofsky NM, Hackney DB. Radiology2011 May259(2):550-7http://www.ncbi.nlm.nih.gov/pubmed/21310726Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease. Brain. 2011 Mar; 134(Pt 3):845-55.Melzer TR, Watts R, MacAskill MR, Pearson JF, Rüeger S, Pitcher TL, Livingston L, Graham C, Keenan R, Shankaranarayanan A, Alsop DC, Dalrymple-Alford JC, Anderson TJ. Brain2011 Mar134(Pt 3):845-55http://www.ncbi.nlm.nih.gov/pubmed/20959548Time-resolved vessel-selective digital subtraction MR angiography of the cerebral vasculature with arterial spin labeling. Radiology. 2010 Nov; 257(2):507-15.Robson PM, Dai W, Shankaranarayanan A, Rofsky NM, Alsop DC. Radiology2010 Nov257(2):507-15http://www.ncbi.nlm.nih.gov/pubmed/20665896Modified pulsed continuous arterial spin labeling for labeling of a single artery. Magn Reson Med. 2010 Oct; 64(4):975-82.Dai W, Robson PM, Shankaranarayanan A, Alsop DC. Magn Reson Med2010 Oct64(4):975-82http://www.ncbi.nlm.nih.gov/pubmed/20876450Hypertension and cerebral vasoreactivity: a continuous arterial spin labeling magnetic resonance imaging study. Hypertension. 2010 Nov; 56(5):859-64.Hajjar I, Zhao P, Alsop D, Novak V. Hypertension2010 Nov56(5):859-64http://www.ncbi.nlm.nih.gov/pubmed/20862658Blood flow quantification of the human retina with MRI. NMR Biomed. 2011 Jan; 24(1):104-11.Maleki N, Dai W, Alsop DC. NMR Biomed2011 Jan24(1):104-11http://www.ncbi.nlm.nih.gov/pubmed/20699227Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling. Mol Cancer Ther. 2010 Oct; 9(10):2793-802.Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, Goldberg SN, Atkins MB, Mier JW. Mol Cancer Ther2010 Oct9(10):2793-802http://www.ncbi.nlm.nih.gov/pubmed/20472198Perfusion MRI demonstrates crossed-cerebellar diaschisis in sickle cell disease. Pediatr Neurol. 2010 Jun; 42(6):437-40.O'Gorman RL, Siddiqui A, Alsop DC, Jarosz JM. Pediatr Neurol2010 Jun42(6):437-40http://www.ncbi.nlm.nih.gov/pubmed/20488671Volumetric cerebral perfusion imaging in healthy adults: regional distribution, laterality, and repeatability of pulsed continuous arterial spin labeling (PCASL). Psychiatry Res. 2010 Jun 30; 182(3):266-73.Pfefferbaum A, Chanraud S, Pitel AL, Shankaranarayanan A, Alsop DC, Rohlfing T, Sullivan EV. Psychiatry Res2010 Jun 30182(3):266-73http://www.ncbi.nlm.nih.gov/pubmed/20484322Cerebral blood flow in posterior cortical nodes of the default mode network decreases with task engagement but remains higher than in most brain regions. Cereb Cortex. 2011 Jan; 21(1):233-44.Pfefferbaum A, Chanraud S, Pitel AL, Müller-Oehring E, Shankaranarayanan A, Alsop DC, Rohlfing T, Sullivan EV. Cereb Cortex2011 Jan21(1):233-44http://www.ncbi.nlm.nih.gov/pubmed/19953503Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease. NMR Biomed. 2010 Apr; 23(3):286-93.Xu G, Rowley HA, Wu G, Alsop DC, Shankaranarayanan A, Dowling M, Christian BT, Oakes TR, Johnson SC. NMR Biomed2010 Apr23(3):286-93http://www.ncbi.nlm.nih.gov/pubmed/20142612Altered control of postural sway following cerebral infarction: a cross-sectional analysis. Neurology. 2010 Feb 09; 74(6):458-64.Manor B, Hu K, Zhao P, Selim M, Alsop D, Novak P, Lipsitz L, Novak V. Neurology2010 Feb 0974(6):458-64http://www.ncbi.nlm.nih.gov/pubmed/20104068Aging, brain disease, and reserve: implications for delirium. Am J Geriatr Psychiatry. 2010 Feb; 18(2):117-27.Jones RN, Fong TG, Metzger E, Tulebaev S, Yang FM, Alsop DC, Marcantonio ER, Cupples LA, Gottlieb G, Inouye SK. Am J Geriatr Psychiatry2010 Feb18(2):117-27http://www.ncbi.nlm.nih.gov/pubmed/20101033Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke. Neurology. 2010 Jan 26; 74(4):280-7.Lindenberg R, Renga V, Zhu LL, Betzler F, Alsop D, Schlaug G. Neurology2010 Jan 2674(4):280-7http://www.ncbi.nlm.nih.gov/pubmed/20051975Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI. J Cereb Blood Flow Metab. 2010 Mar; 30(3):505-9.Ma Y, Huang C, Dyke JP, Pan H, Alsop D, Feigin A, Eidelberg D. J Cereb Blood Flow Metab2010 Mar30(3):505-9http://www.ncbi.nlm.nih.gov/pubmed/19918889A multislice gradient echo pulse sequence for CEST imaging. Magn Reson Med. 2010 Jan; 63(1):253-6.Dixon WT, Hancu I, Ratnakar SJ, Sherry AD, Lenkinski RE, Alsop DC. Magn Reson Med2010 Jan63(1):253-6http://www.ncbi.nlm.nih.gov/pubmed/20413865Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease. J Alzheimers Dis. 2010; 20(3):871-80.Alsop DC, Dai W, Grossman M, Detre JA. J Alzheimers Dis201020(3):871-80http://www.ncbi.nlm.nih.gov/pubmed/19841916Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging. Neuroradiology. 2010 Apr; 52(4):307-17.Järnum H, Steffensen EG, Knutsson L, Fründ ET, Simonsen CW, Lundbye-Christensen S, Shankaranarayanan A, Alsop DC, Jensen FT, Larsson EM. Neuroradiology2010 Apr52(4):307-17http://www.ncbi.nlm.nih.gov/pubmed/19798036Association of blood pressure elevation and nocturnal dipping with brain atrophy, perfusion and functional measures in stroke and nonstroke individuals. Am J Hypertens. 2010 Jan; 23(1):17-23.Hajjar I, Zhao P, Alsop D, Abduljalil A, Selim M, Novak P, Novak V. Am J Hypertens2010 Jan23(1):17-23http://www.ncbi.nlm.nih.gov/pubmed/19692596Tone deafness: a new disconnection syndrome? J Neurosci. 2009 Aug 19; 29(33):10215-20.Loui P, Alsop D, Schlaug G. J Neurosci2009 Aug 1929(33):10215-20http://www.ncbi.nlm.nih.gov/pubmed/19703858Arterial spin-label imaging in patients with normal bolus perfusion-weighted MR imaging findings: pilot identification of the borderzone sign. Radiology. 2009 Sep; 252(3):797-807.Zaharchuk G, Bammer R, Straka M, Shankaranarayan A, Alsop DC, Fischbein NJ, Atlas SW, Moseley ME. Radiology2009 Sep252(3):797-807http://www.ncbi.nlm.nih.gov/pubmed/19319891Strategies for reducing respiratory motion artifacts in renal perfusion imaging with arterial spin labeling. Magn Reson Med. 2009 Jun; 61(6):1374-87.Robson PM, Madhuranthakam AJ, Dai W, Pedrosa I, Rofsky NM, Alsop DC. Magn Reson Med2009 Jun61(6):1374-87http://www.ncbi.nlm.nih.gov/pubmed/19474376Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model? Radiology. 2009 Jun; 251(3):731-42.Schor-Bardach R, Alsop DC, Pedrosa I, Solazzo SA, Wang X, Marquis RP, Atkins MB, Regan M, Signoretti S, Lenkinski RE, Goldberg SN. Radiology2009 Jun251(3):731-42http://www.ncbi.nlm.nih.gov/pubmed/19402070Magnetic resonance imaging as a biomarker in renal cell carcinoma. Cancer. 2009 May 15; 115(10 Suppl):2334-45.Pedrosa I, Alsop DC, Rofsky NM. Cancer2009 May 15115(10 Suppl):2334-45http://www.ncbi.nlm.nih.gov/pubmed/19178916Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study. J Neurol Sci. 2009 Apr 15; 279(1-2):99-105.Stankiewicz JM, Neema M, Alsop DC, Healy BC, Arora A, Buckle GJ, Chitnis T, Guttmann CR, Hackney D, Bakshi R. J Neurol Sci2009 Apr 15279(1-2):99-105http://www.ncbi.nlm.nih.gov/pubmed/192818503 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis. Neuroimage. 2009 Jul 01; 46(3):633-41.Neema M, Goldberg-Zimring D, Guss ZD, Healy BC, Guttmann CR, Houtchens MK, Weiner HL, Horsfield MA, Hackney DB, Alsop DC, Bakshi R. Neuroimage2009 Jul 0146(3):633-41http://www.ncbi.nlm.nih.gov/pubmed/19250785White matter hyperintensities and dynamics of postural control. Magn Reson Imaging. 2009 Jul; 27(6):752-9.Novak V, Haertle M, Zhao P, Hu K, Munshi M, Novak P, Abduljalil A, Alsop D. Magn Reson Imaging2009 Jul27(6):752-9http://www.ncbi.nlm.nih.gov/pubmed/19221298Vasoreactivity and peri-infarct hyperintensities in stroke. Neurology. 2009 Feb 17; 72(7):643-9.Zhao P, Alsop DC, Abduljalil A, Selim M, Lipsitz L, Novak P, Caplan L, Hu K, Novak V. Neurology2009 Feb 1772(7):643-9http://www.ncbi.nlm.nih.gov/pubmed/19025913Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med. 2008 Dec; 60(6):1488-97.Dai W, Garcia D, de Bazelaire C, Alsop DC. Magn Reson Med2008 Dec60(6):1488-97http://www.ncbi.nlm.nih.gov/pubmed/18765547Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. Clin Cancer Res. 2008 Sep 01; 14(17):5548-54.de Bazelaire C, Alsop DC, George D, Pedrosa I, Wang Y, Michaelson MD, Rofsky NM. Clin Cancer Res2008 Sep 0114(17):5548-54http://www.ncbi.nlm.nih.gov/pubmed/18662204Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivators. J Am Geriatr Soc. 2008 Aug; 56(8):1522-7.Marcantonio ER, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK. J Am Geriatr Soc2008 Aug56(8):1522-7http://www.ncbi.nlm.nih.gov/pubmed/18602481Hippocampal hyperperfusion in Alzheimer's disease. Neuroimage. 2008 Oct 01; 42(4):1267-74.Alsop DC, Casement M, de Bazelaire C, Fong T, Press DZ. Neuroimage2008 Oct 0142(4):1267-74http://www.ncbi.nlm.nih.gov/pubmed/18506787B1-insensitive fast spin echo using adiabatic square wave enabling of the echo train (SWEET) excitation. Magn Reson Med. 2008 Jun; 59(6):1386-93.Madhuranthakam AJ, Busse RF, Brittain JH, Rofsky NM, Alsop DC. Magn Reson Med2008 Jun59(6):1386-93http://www.ncbi.nlm.nih.gov/pubmed/20157644Atorvastatin therapy is associated with greater and faster cerebral hemodynamic response. Brain Imaging Behav. 2008 Jun 01; 2(2):94.Xu G, Fitzgerald ME, Wen Z, Fain SB, Alsop DC, Carroll T, Ries ML, Rowley HA, Sager MA, Asthana S, Johnson SC, Carlsson CM. Brain Imaging Behav2008 Jun 012(2):94http://www.ncbi.nlm.nih.gov/pubmed/18511306Increased cerebral perfusion in adult attention deficit hyperactivity disorder is normalised by stimulant treatment: a non-invasive MRI pilot study. Neuroimage. 2008 Aug 01; 42(1):36-41.O'Gorman RL, Mehta MA, Asherson P, Zelaya FO, Brookes KJ, Toone BK, Alsop DC, Williams SC. Neuroimage2008 Aug 0142(1):36-41http://www.ncbi.nlm.nih.gov/pubmed/18186943Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas. Cerebrospinal Fluid Res. 2008 Jan 11; 5:1.Wong ET, Alsop D, Lee D, Tam A, Barron L, Bloom J, Gautam S, Wu JK. Cerebrospinal Fluid Res2008 Jan 115:1http://www.ncbi.nlm.nih.gov/pubmed/18056578A structural basis for reading fluency: white matter defects in a genetic brain malformation. Neurology. 2007 Dec 04; 69(23):2146-54.Chang BS, Katzir T, Liu T, Corriveau K, Barzillai M, Apse KA, Bodell A, Hackney D, Alsop D, Wong ST, Wong S, Walsh CA. Neurology2007 Dec 0469(23):2146-54http://www.ncbi.nlm.nih.gov/pubmed/17954778Activation and baseline changes in functional MRI studies of Alzheimer disease. Neurology. 2007 Oct 23; 69(17):1645-6.Alsop DC, Press DZ. Neurology2007 Oct 2369(17):1645-6http://www.ncbi.nlm.nih.gov/pubmed/17988892Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI. Neuroimage. 2008 Feb 01; 39(3):973-8.Wang Z, Fernández-Seara M, Alsop DC, Liu WC, Flax JF, Benasich AA, Detre JA. Neuroimage2008 Feb 0139(3):973-8http://www.ncbi.nlm.nih.gov/pubmed/17279531Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling. J Magn Reson Imaging. 2007 Apr; 25(4):696-702.Biagi L, Abbruzzese A, Bianchi MC, Alsop DC, Del Guerra A, Tosetti M. J Magn Reson Imaging2007 Apr25(4):696-702http://www.ncbi.nlm.nih.gov/pubmed/17290035Global and regional effects of type 2 diabetes on brain tissue volumes and cerebral vasoreactivity. Diabetes Care. 2007 May; 30(5):1193-9.Last D, Alsop DC, Abduljalil AM, Marquis RP, de Bazelaire C, Hu K, Cavallerano J, Novak V. Diabetes Care2007 May30(5):1193-9http://www.ncbi.nlm.nih.gov/pubmed/17234821Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1281-6.Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK. J Gerontol A Biol Sci Med Sci2006 Dec61(12):1281-6http://www.ncbi.nlm.nih.gov/pubmed/17234822The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1287-93.Alsop DC, Fearing MA, Johnson K, Sperling R, Fong TG, Inouye SK. J Gerontol A Biol Sci Med Sci2006 Dec61(12):1287-93http://www.ncbi.nlm.nih.gov/pubmed/16804888Effects of cord motion on diffusion imaging of the spinal cord. Magn Reson Med. 2006 Aug; 56(2):334-9.Kharbanda HS, Alsop DC, Anderson AW, Filardo G, Hackney DB. Magn Reson Med2006 Aug56(2):334-9http://www.ncbi.nlm.nih.gov/pubmed/16791859Limits on activation-induced temperature and metabolic changes in the human primary visual cortex. Magn Reson Med. 2006 Aug; 56(2):348-55.Katz-Brull R, Alsop DC, Marquis RP, Lenkinski RE. Magn Reson Med2006 Aug56(2):348-55http://www.ncbi.nlm.nih.gov/pubmed/16317710Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp. 2006 Aug; 27(8):662-77.Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Hum Brain Mapp2006 Aug27(8):662-77http://www.ncbi.nlm.nih.gov/pubmed/16801574Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care. 2006 Jul; 29(7):1529-34.Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA. Diabetes Care2006 Jul29(7):1529-34http://www.ncbi.nlm.nih.gov/pubmed/16673361In vivo estimation of the flow-driven adiabatic inversion efficiency for continuous arterial spin labeling: a method using phase contrast magnetic resonance angiography. Magn Reson Med. 2006 Jun; 55(6):1291-7.O'Gorman RL, Summers PE, Zelaya FO, Williams SC, Alsop DC, Lythgoe DJ. Magn Reson Med2006 Jun55(6):1291-7http://www.ncbi.nlm.nih.gov/pubmed/16583215Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol. 2006 Sep; 16(9):2083-91.de Bazelaire C, Rofsky NM, Duhamel G, Zhang J, Michaelson MD, George D, Alsop DC. Eur Radiol2006 Sep16(9):2083-91http://www.ncbi.nlm.nih.gov/pubmed/16529951Personality factors correlate with regional cerebral perfusion. Neuroimage. 2006 Jun; 31(2):489-95.O'Gorman RL, Kumari V, Williams SC, Zelaya FO, Connor SE, Alsop DC, Gray JA. Neuroimage2006 Jun31(2):489-95http://www.ncbi.nlm.nih.gov/pubmed/16463343Measurement of arterial input functions for dynamic susceptibility contrast magnetic resonance imaging using echoplanar images: comparison of physical simulations with in vivo results. Magn Reson Med. 2006 Mar; 55(3):514-23.Duhamel G, Schlaug G, Alsop DC. Magn Reson Med2006 Mar55(3):514-23http://www.ncbi.nlm.nih.gov/pubmed/16275018Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage. 2006 Apr 01; 30(2):588-600.Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Neuroimage2006 Apr 0130(2):588-600http://www.ncbi.nlm.nih.gov/pubmed/16032674Efficiency of inversion pulses for background suppressed arterial spin labeling. Magn Reson Med. 2005 Aug; 54(2):366-72.Garcia DM, Duhamel G, Alsop DC. Magn Reson Med2005 Aug54(2):366-72http://www.ncbi.nlm.nih.gov/pubmed/27946984Arterial spin labeling MRI detects early recurrence and anti-angiogenic drug effect in recurrent malignant gliomas. J Clin Oncol. 2005 Jun; 23(16_suppl):1573.Wong ET, Appignani B, Wu JK, Mahadevan A, Joseph JJ, Lee D, Tam A, Bloom J, Barron L, Hackney D, Alsop D. J Clin Oncol2005 Jun23(16_suppl):1573http://www.ncbi.nlm.nih.gov/pubmed/15850725Adults and children processing music: an fMRI study. Neuroimage. 2005 May 01; 25(4):1068-76.Koelsch S, Fritz T, Schulze K, Alsop D, Schlaug G. Neuroimage2005 May 0125(4):1068-76http://www.ncbi.nlm.nih.gov/pubmed/15746457Markedly reduced apparent blood volume on bolus contrast magnetic resonance imaging as a predictor of hemorrhage after thrombolytic therapy for acute ischemic stroke. Stroke. 2005 Apr; 36(4):746-50.Alsop DC, Makovetskaya E, Kumar S, Selim M, Schlaug G. Stroke2005 Apr36(4):746-50http://www.ncbi.nlm.nih.gov/pubmed/15766695Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol. 2005 Mar; 12(3):347-57.De Bazelaire C, Rofsky NM, Duhamel G, Michaelson MD, George D, Alsop DC. Acad Radiol2005 Mar12(3):347-57http://www.ncbi.nlm.nih.gov/pubmed/15716390Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. Radiology. 2005 Apr; 235(1):218-28.Wang J, Zhang Y, Wolf RL, Roc AC, Alsop DC, Detre JA. Radiology2005 Apr235(1):218-28http://www.ncbi.nlm.nih.gov/pubmed/15964485Sleep-dependent motor memory plasticity in the human brain. Neuroscience. 2005; 133(4):911-7.Walker MP, Stickgold R, Alsop D, Gaab N, Schlaug G. Neuroscience2005133(4):911-7http://www.ncbi.nlm.nih.gov/pubmed/15257135Imaging melody and rhythm processing in young children. Neuroreport. 2004 Aug 06; 15(11):1723-6.Overy K, Norton AC, Cronin KT, Gaab N, Alsop DC, Winner E, Schlaug G. Neuroreport2004 Aug 0615(11):1723-6http://www.ncbi.nlm.nih.gov/pubmed/15095558Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy. J Neuroimaging. 2004 Apr; 14(2):133-8.Ances BM, McGarvey ML, Abrahams JM, Maldjian JA, Alsop DC, Zager EL, Detre JA. J Neuroimaging2004 Apr14(2):133-8http://www.ncbi.nlm.nih.gov/pubmed/14990831MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology. 2004 Mar; 230(3):652-9.de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. Radiology2004 Mar230(3):652-9http://www.ncbi.nlm.nih.gov/pubmed/14972387Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 Tesla. Magn Reson Imaging. 2004 Jan; 22(1):1-7.Wang J, Li L, Roc AC, Alsop DC, Tang K, Butler NS, Schnall MD, Detre JA. Magn Reson Imaging2004 Jan22(1):1-7http://www.ncbi.nlm.nih.gov/pubmed/14599278Neural basis for verb processing in Alzheimer's disease: an fMRI study. Neuropsychology. 2003 Oct; 17(4):658-74.Grossman M, Koenig P, DeVita C, Glosser G, Moore P, Gee J, Detre J, Alsop D. Neuropsychology2003 Oct17(4):658-74http://www.ncbi.nlm.nih.gov/pubmed/12939768Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med. 2003 Sep; 50(3):599-607.Wang J, Alsop DC, Song HK, Maldjian JA, Tang K, Salvucci AE, Detre JA. Magn Reson Med2003 Sep50(3):599-607http://www.ncbi.nlm.nih.gov/pubmed/12815689Evaluation of systematic quantification errors in velocity-selective arterial spin labeling of the brain. Magn Reson Med. 2003 Jul; 50(1):145-53.Duhamel G, de Bazelaire C, Alsop DC. Magn Reson Med2003 Jul50(1):145-53http://www.ncbi.nlm.nih.gov/pubmed/12833601[Diffusion imaging]. Nihon Igaku Hoshasen Gakkai Zasshi. 2003 May; 63(5 Suppl):2-7.Takahashi M, Uematsu H, Alsop DC. Nihon Igaku Hoshasen Gakkai Zasshi2003 May63(5 Suppl):2-7http://www.ncbi.nlm.nih.gov/pubmed/12735939Neural basis for sentence comprehension deficits in frontotemporal dementia. Brain Lang. 2003 May; 85(2):211-21.Cooke A, DeVita C, Gee J, Alsop D, Detre J, Chen W, Grossman M. Brain Lang2003 May85(2):211-21http://www.ncbi.nlm.nih.gov/pubmed/12629232Grammatical and resource components of sentence processing in Parkinson's disease: an fMRI study. Neurology. 2003 Mar 11; 60(5):775-81.Grossman M, Cooke A, DeVita C, Lee C, Alsop D, Detre J, Gee J, Chen W, Stern MB, Hurtig HI. Neurology2003 Mar 1160(5):775-81http://www.ncbi.nlm.nih.gov/pubmed/12498962Age-related differences in brain activation during emotional face processing. Neurobiol Aging. 2003 Mar-Apr; 24(2):285-95.Gunning-Dixon FM, Gur RC, Perkins AC, Schroeder L, Turner T, Turetsky BI, Chan RM, Loughead JW, Alsop DC, Maldjian J, Gur RE. Neurobiol Aging2003 Mar-Apr24(2):285-95http://www.ncbi.nlm.nih.gov/pubmed/12538399Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study. Brain. 2003 Feb; 126(Pt 2):292-311.Grossman M, Koenig P, Glosser G, DeVita C, Moore P, Rhee J, Detre J, Alsop D, Gee J. Brain2003 Feb126(Pt 2):292-311http://www.ncbi.nlm.nih.gov/pubmed/12593127Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease. J Neuroimaging. 2003 Jan; 13(1):17-27.Wolf RL, Alsop DC, McGarvey ML, Maldjian JA, Wang J, Detre JA. J Neuroimaging2003 Jan13(1):17-27http://www.ncbi.nlm.nih.gov/pubmed/12450947An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry. 2002 Dec; 159(12):1992-9.Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian J, Ragland JD, Gur RC. Am J Psychiatry2002 Dec159(12):1992-9http://www.ncbi.nlm.nih.gov/pubmed/12210932Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med. 2002 Aug; 48(2):242-54.Wang J, Alsop DC, Li L, Listerud J, Gonzalez-At JB, Schnall MD, Detre JA. Magn Reson Med2002 Aug48(2):242-54http://www.ncbi.nlm.nih.gov/pubmed/12169250Brain activation during facial emotion processing. Neuroimage. 2002 Jul; 16(3 Pt 1):651-62.Gur RC, Schroeder L, Turner T, McGrath C, Chan RM, Turetsky BI, Alsop D, Maldjian J, Gur RE. Neuroimage2002 Jul16(3 Pt 1):651-62http://www.ncbi.nlm.nih.gov/pubmed/11906234The neural basis for category-specific knowledge: an fMRI study. Neuroimage. 2002 Apr; 15(4):936-48.Grossman M, Koenig P, DeVita C, Glosser G, Alsop D, Detre J, Gee J. Neuroimage2002 Apr15(4):936-48http://www.ncbi.nlm.nih.gov/pubmed/11848692Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage. 2002 Mar; 15(3):488-500.Aguirre GK, Detre JA, Zarahn E, Alsop DC. Neuroimage2002 Mar15(3):488-500http://www.ncbi.nlm.nih.gov/pubmed/11896642Neural correlates of successful and unsuccessful verbal memory encoding. Brain Lang. 2002 Mar; 80(3):287-95.Casasanto DJ, Killgore WD, Maldjian JA, Glosser G, Alsop DC, Cooke AM, Grossman M, Detre JA. Brain Lang2002 Mar80(3):287-95http://www.ncbi.nlm.nih.gov/pubmed/11896643Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study. Brain Lang. 2002 Mar; 80(3):296-313.Grossman M, Cooke A, DeVita C, Chen W, Moore P, Detre J, Alsop D, Gee J. Brain Lang2002 Mar80(3):296-313http://www.ncbi.nlm.nih.gov/pubmed/11970782Neural specialization for letter recognition. J Cogn Neurosci. 2002 Feb 15; 14(2):145-59.Polk TA, Stallcup M, Aguirre GK, Alsop DC, D'Esposito M, Detre JA, Farah MJ. J Cogn Neurosci2002 Feb 1514(2):145-59http://www.ncbi.nlm.nih.gov/pubmed/11798267Age-related changes in working memory during sentence comprehension: an fMRI study. Neuroimage. 2002 Feb; 15(2):302-17.Grossman M, Cooke A, DeVita C, Alsop D, Detre J, Chen W, Gee J. Neuroimage2002 Feb15(2):302-17http://www.ncbi.nlm.nih.gov/pubmed/11835600Neural basis for sentence comprehension: grammatical and short-term memory components. Hum Brain Mapp. 2002 Feb; 15(2):80-94.Cooke A, Zurif EB, DeVita C, Alsop D, Koenig P, Detre J, Gee J, Pinãngo M, Balogh J, Grossman M. Hum Brain Mapp2002 Feb15(2):80-94http://www.ncbi.nlm.nih.gov/pubmed/11835603Neural representation of verb meaning: an fMRI study. Hum Brain Mapp. 2002 Feb; 15(2):124-34.Grossman M, Koenig P, DeVita C, Glosser G, Alsop D, Detre J, Gee J. Hum Brain Mapp2002 Feb15(2):124-34http://www.ncbi.nlm.nih.gov/pubmed/11770915Brain activity mapping with functional MR imaging. Acad Radiol. 2001 Dec; 8(12):1195-7.Alsop D. Acad Radiol2001 Dec8(12):1195-7http://www.ncbi.nlm.nih.gov/pubmed/11677889Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy. J Neuroimaging. 2001 Oct; 11(4):444-6.Chalela JA, Kasner SE, McGarvey M, Alsop DC, Detre JA. J Neuroimaging2001 Oct11(4):444-6http://www.ncbi.nlm.nih.gov/pubmed/11498422Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol. 2001 Aug; 22(7):1334-41.Wolf RL, Alsop DC, Levy-Reis I, Meyer PT, Maldjian JA, Gonzalez-Atavales J, French JA, Alavi A, Detre JA. AJNR Am J Neuroradiol2001 Aug22(7):1334-41http://www.ncbi.nlm.nih.gov/pubmed/11159112Neuropsychologic performance after resection of an activation cluster involved in cognitive memory function. AJR Am J Roentgenol. 2001 Feb; 176(2):541-4.Maldjian JA, Detre JA, Killgore WD, Judy K, Alsop D, Grossman M, Glosser G. AJR Am J Roentgenol2001 Feb176(2):541-4http://www.ncbi.nlm.nih.gov/pubmed/11147403Cortical reorganization in linear nevus sebaceous syndrome: a multimodality neuroimaging study. J Neuroimaging. 2000 Oct; 10(4):225-8.Levy-Reis I, Casasanto DJ, Gonzalez JB, Alsop DC, Glosser G, Maldjan JA, French J, Detre JA. J Neuroimaging2000 Oct10(4):225-8http://www.ncbi.nlm.nih.gov/pubmed/10950912An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang. 2000 Sep; 74(2):157-70.Gur RC, Alsop D, Glahn D, Petty R, Swanson CL, Maldjian JA, Turetsky BI, Detre JA, Gee J, Gur RE. Brain Lang2000 Sep74(2):157-70http://www.ncbi.nlm.nih.gov/pubmed/10930019Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. J Neurosurg. 2000 Aug; 93(2):315-22.Smith DH, Nonaka M, Miller R, Leoni M, Chen XH, Alsop D, Meaney DF. J Neurosurg2000 Aug93(2):315-22http://www.ncbi.nlm.nih.gov/pubmed/10800025Intermolecular zero-quantum coherence imaging of the human brain. Magn Reson Med. 2000 May; 43(5):627-32.Rizi RR, Ahn S, Alsop DC, Garrett-Roe S, Mescher M, Richter W, Schnall MD, Leigh JS, Warren WS. Magn Reson Med2000 May43(5):627-32http://www.ncbi.nlm.nih.gov/pubmed/10800040Cerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling. Magn Reson Med. 2000 May; 43(5):739-46.Gonzalez-At JB, Alsop DC, Detre JA. Magn Reson Med2000 May43(5):739-46http://www.ncbi.nlm.nih.gov/pubmed/10700504Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke. 2000 Mar; 31(3):680-7.Chalela JA, Alsop DC, Gonzalez-Atavales JB, Maldjian JA, Kasner SE, Detre JA. Stroke2000 Mar31(3):680-7http://www.ncbi.nlm.nih.gov/pubmed/10632106Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Ann Neurol. 2000 Jan; 47(1):93-100.Alsop DC, Detre JA, Grossman M. Ann Neurol2000 Jan47(1):93-100http://www.ncbi.nlm.nih.gov/pubmed/10627406Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control. Seizure. 1999 Dec; 8(8):450-5.Killgore WD, Glosser G, Casasanto DJ, French JA, Alsop DC, Detre JA. Seizure1999 Dec8(8):450-5http://www.ncbi.nlm.nih.gov/pubmed/10548801Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis. J Magn Reson Imaging. 1999 Nov; 10(5):870-5.Detre JA, Samuels OB, Alsop DC, Gonzalez-At JB, Kasner SE, Raps EC. J Magn Reson Imaging1999 Nov10(5):870-5http://www.ncbi.nlm.nih.gov/pubmed/10385581The sensory somatotopic map of the human hand demonstrated at 4 Tesla. Neuroimage. 1999 Jul; 10(1):55-62.Maldjian JA, Gottschalk A, Patel RS, Detre JA, Alsop DC. Neuroimage1999 Jul10(1):55-62http://www.ncbi.nlm.nih.gov/pubmed/10401592Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur J Radiol. 1999 May; 30(2):115-24.Detre JA, Alsop DC. Eur J Radiol1999 May30(2):115-24http://www.ncbi.nlm.nih.gov/pubmed/10196461Mapping of secondary somatosensory cortex activation induced by vibrational stimulation: an fMRI study. Brain Res. 1999 Apr 10; 824(2):291-5.Maldjian JA, Gottschalk A, Patel RS, Pincus D, Detre JA, Alsop DC. Brain Res1999 Apr 10824(2):291-5http://www.ncbi.nlm.nih.gov/pubmed/10319969The effect of age on odor-stimulated functional MR imaging. AJNR Am J Neuroradiol. 1999 Apr; 20(4):600-8.Yousem DM, Maldjian JA, Hummel T, Alsop DC, Geckle RJ, Kraut MA, Doty RL. AJNR Am J Neuroradiol1999 Apr20(4):600-8http://www.ncbi.nlm.nih.gov/pubmed/10399610T2* and proton density measurement of normal human lung parenchyma using submillisecond echo time gradient echo magnetic resonance imaging. Eur J Radiol. 1999 Mar; 29(3):245-52.Hatabu H, Alsop DC, Listerud J, Bonnet M, Gefter WB. Eur J Radiol1999 Mar29(3):245-52http://www.ncbi.nlm.nih.gov/pubmed/10082834Gender effects on odor-stimulated functional magnetic resonance imaging. Brain Res. 1999 Feb 13; 818(2):480-7.Yousem DM, Maldjian JA, Siddiqi F, Hummel T, Alsop DC, Geckle RJ, Bilker WB, Doty RL. Brain Res1999 Feb 13818(2):480-7http://www.ncbi.nlm.nih.gov/pubmed/9680569Multisection cerebral blood flow MR imaging with continuous arterial spin labeling. Radiology. 1998 Aug; 208(2):410-6.Alsop DC, Detre JA. Radiology1998 Aug208(2):410-6http://www.ncbi.nlm.nih.gov/pubmed/9660552A spiral volume coil for improved RF field homogeneity at high static magnetic field strength. Magn Reson Med. 1998 Jul; 40(1):49-54.Alsop DC, Connick TJ, Mizsei G. Magn Reson Med1998 Jul40(1):49-54http://www.ncbi.nlm.nih.gov/pubmed/9566374Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology. 1998 Apr; 50(4):926-32.Detre JA, Maccotta L, King D, Alsop DC, Glosser G, D'Esposito M, Zarahn E, Aguirre GK, French JA. Neurology1998 Apr50(4):926-32http://www.ncbi.nlm.nih.gov/pubmed/9521248Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease. Neurology. 1998 Mar; 50(3):633-41.Detre JA, Alsop DC, Vives LR, Maccotta L, Teener JW, Raps EC. Neurology1998 Mar50(3):633-41http://www.ncbi.nlm.nih.gov/pubmed/9324317Phase insensitive preparation of single-shot RARE: application to diffusion imaging in humans. Magn Reson Med. 1997 Oct; 38(4):527-33.Alsop DC. Magn Reson Med1997 Oct38(4):527-33http://www.ncbi.nlm.nih.gov/pubmed/9232859Optical investigations of physiology: a study of intrinsic and extrinsic biomedical contrast. Philos Trans R Soc Lond B Biol Sci. 1997 Jun 29; 352(1354):707-16.Chance B, Luo Q, Nioka S, Alsop DC, Detre JA. Philos Trans R Soc Lond B Biol Sci1997 Jun 29352(1354):707-16http://www.ncbi.nlm.nih.gov/pubmed/9430351The efficiency of adiabatic inversion for perfusion imaging by arterial spin labeling. NMR Biomed. 1997 Jun-Aug; 10(4-5):216-21.Maccotta L, Detre JA, Alsop DC. NMR Biomed1997 Jun-Aug10(4-5):216-21http://www.ncbi.nlm.nih.gov/pubmed/9129112Correlation of diffusion MRI and heat shock protein in a rat embolic stroke model. J Neurol Sci. 1997 May 29; 148(2):163-9.Detre JA, Zager EL, Alsop DC, Harris VA, Welsh FA. J Neurol Sci1997 May 29148(2):163-9http://www.ncbi.nlm.nih.gov/pubmed/9153035A functional MRI study of mental image generation. Neuropsychologia. 1997 May; 35(5):725-30.D'Esposito M, Detre JA, Aguirre GK, Stallcup M, Alsop DC, Tippet LJ, Farah MJ. Neuropsychologia1997 May35(5):725-30http://www.ncbi.nlm.nih.gov/pubmed/9001140The sensitivity of low flip angle RARE imaging. Magn Reson Med. 1997 Feb; 37(2):176-84.Alsop DC. Magn Reson Med1997 Feb37(2):176-84http://www.ncbi.nlm.nih.gov/pubmed/8898697Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab. 1996 Nov; 16(6):1236-49.Alsop DC, Detre JA. J Cereb Blood Flow Metab1996 Nov16(6):1236-49http://www.ncbi.nlm.nih.gov/pubmed/8922339The parahippocampus subserves topographical learning in man. Cereb Cortex. 1996 Nov-Dec; 6(6):823-9.Aguirre GK, Detre JA, Alsop DC, D'Esposito M. Cereb Cortex1996 Nov-Dec6(6):823-9http://www.ncbi.nlm.nih.gov/pubmed/8913968Detection of acute pathologic changes following experimental traumatic brain injury using diffusion-weighted magnetic resonance imaging. J Neurotrauma. 1996 Sep; 13(9):515-21.Alsop DC, Murai H, Detre JA, McIntosh TK, Smith DH. J Neurotrauma1996 Sep13(9):515-21http://www.ncbi.nlm.nih.gov/pubmed/9345496Functional activation during an auditory comprehension task in patients with temporal lobe lesions. Neuroimage. 1996 Aug; 4(1):55-9.Alsop DC, Detre JA, D'Esposito M, Howard RS, Maldjian JA, Grossman M, Listerud J, Flamm ES, Judy KD, Atlas SW. Neuroimage1996 Aug4(1):55-9http://www.ncbi.nlm.nih.gov/pubmed/8681898Coupling of cortical and thalamic ictal activity in human partial epilepsy: demonstration by functional magnetic resonance imaging. Epilepsia. 1996 Jul; 37(7):657-61.Detre JA, Alsop DC, Aguirre GK, Sperling MR. Epilepsia1996 Jul37(7):657-61http://www.ncbi.nlm.nih.gov/pubmed/8744016Optimization of torque-balanced asymmetric head gradient coils. Magn Reson Med. 1996 Jun; 35(6):875-86.Alsop DC, Connick TJ. Magn Reson Med1996 Jun35(6):875-86http://www.ncbi.nlm.nih.gov/pubmed/8609561Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy. J Neurosurg. 1996 Mar; 84(3):477-83.Maldjian J, Atlas SW, Howard RS, Greenstein E, Alsop D, Detre JA, Listerud J, D'Esposito M, Flamm ES. J Neurosurg1996 Mar84(3):477-83http://www.ncbi.nlm.nih.gov/pubmed/8869061Functional magnetic resonance imaging of regional brain activity in patients with intracerebral gliomas: findings and implications for clinical management. Neurosurgery. 1996 Feb; 38(2):329-38.Atlas SW, Howard RS, Maldjian J, Alsop D, Detre JA, Listerud J, D'Esposito M, Judy KD, Zager E, Stecker M. Neurosurgery1996 Feb38(2):329-38http://www.ncbi.nlm.nih.gov/pubmed/7477346The neural basis of the central executive system of working memory. Nature. 1995 Nov 16; 378(6554):279-81.D'Esposito M, Detre JA, Alsop DC, Shin RK, Atlas S, Grossman M. 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Scales11.514055398756599e-0022016-04-18T00:00:002016-04-18T00:00:00Expressed Emotion11.500371009023379e-0022006-08-01T00:00:002006-08-01T00:00:00Bone and Bones11.495799715397970e-0022016-09-24T00:00:002016-09-24T00:00:00Up-Regulation11.495076988854065e-0022015-01-14T00:00:002015-01-14T00:00:00Gene Regulatory Networks11.493023613090493e-0022015-01-14T00:00:002015-01-14T00:00:00Receptors, N-Methyl-D-Aspartate11.482883124868481e-0022011-06-16T00:00:002011-06-16T00:00:00Polyethylene Glycols11.480212932668574e-0022011-10-23T00:00:002011-10-23T00:00:00Cholinergic Antagonists11.476485251444540e-0022006-12-01T00:00:002006-12-01T00:00:00Endothelial Cells11.467891948731238e-0022019-02-20T00:00:002019-02-20T00:00:00Least-Squares Analysis11.467565162899364e-0022006-08-01T00:00:002006-08-01T00:00:00Lactates11.457739474655245e-0022006-08-01T00:00:002006-08-01T00:00:00Diffusion21.440937256901248e-0021994-05-01T00:00:002000-03-01T00:00:00Monte Carlo Method11.434637656776378e-0022011-02-25T00:00:002011-02-25T00:00:00Models, Animal11.429946646886735e-0022011-10-19T00:00:002011-10-19T00:00:00Interview, Psychological11.422644069309303e-0022008-07-24T00:00:002008-07-24T00:00:00Multimodal Imaging11.400834703854234e-0022013-10-01T00:00:002013-10-01T00:00:00Comorbidity11.390944617361736e-0022019-09-01T00:00:002019-09-01T00:00:00Middle Cerebral Artery11.363344860706667e-0022006-07-01T00:00:002006-07-01T00:00:00Acetylcholine11.361401970710374e-0022006-12-01T00:00:002006-12-01T00:00:00Ultrasonography, Doppler, Transcranial11.359245456684298e-0022006-07-01T00:00:002006-07-01T00:00:00Thoracic Vertebrae11.332123520507315e-0022009-04-15T00:00:002009-04-15T00:00:00Kidney Transplantation11.313612898075066e-0022019-12-12T00:00:002019-12-12T00:00:00Schizophrenia11.312534645616467e-0022002-12-01T00:00:002002-12-01T00:00:00Child, Preschool41.308210507871094e-0022004-08-06T00:00:002012-02-09T00:00:00Drug Administration Schedule11.307558892668169e-0022011-12-21T00:00:002011-12-21T00:00:00Software11.289547025593331e-0022018-04-29T00:00:002018-04-29T00:00:00Gait11.287553383271077e-0022009-10-01T00:00:002009-10-01T00:00:00Transplantation, Heterologous11.258819127563546e-0022010-08-10T00:00:002010-08-10T00:00:00Blotting, Western11.231476646680889e-0022010-08-10T00:00:002010-08-10T00:00:00Syndrome11.223569959653797e-0022009-08-19T00:00:002009-08-19T00:00:00Length of Stay11.221951508528047e-0022017-05-26T00:00:002017-05-26T00:00:00Logistic Models11.194439940608900e-0022017-06-06T00:00:002017-06-06T00:00:00Cervical Vertebrae11.190912883853175e-0022009-04-15T00:00:002009-04-15T00:00:00Linguistics11.171511847992239e-0022003-03-11T00:00:002003-03-11T00:00:00Biomechanical Phenomena11.162717986514984e-0022010-02-09T00:00:002010-02-09T00:00:00Paired-Associate Learning11.153916035149396e-0022002-04-01T00:00:002002-04-01T00:00:00Serotonin11.148424105025377e-0022006-12-01T00:00:002006-12-01T00:00:00Academic Medical Centers11.142922879221406e-0022012-09-19T00:00:002012-09-19T00:00:00Prevalence11.140101379937476e-0022019-09-01T00:00:002019-09-01T00:00:00Outcome Assessment, Health Care11.129230694292579e-0022017-06-06T00:00:002017-06-06T00:00:00Visual Perception11.098182685010445e-0022010-02-09T00:00:002010-02-09T00:00:00Walking11.096572964783460e-0022009-04-15T00:00:002009-04-15T00:00:00Heart Rate11.084029420038917e-0022013-06-16T00:00:002013-06-16T00:00:00Melatonin11.063661008212765e-0022006-12-01T00:00:002006-12-01T00:00:00Acute Disease21.049735941115626e-0022000-03-01T00:00:002003-01-01T00:00:00Genetic Markers11.042322455805480e-0022006-12-01T00:00:002006-12-01T00:00:00Age Factors11.040547125104723e-0022017-09-12T00:00:002017-09-12T00:00:00Happiness11.040079310026658e-0022002-07-01T00:00:002002-07-01T00:00:00Judgment11.034404670428164e-0022003-02-01T00:00:002003-02-01T00:00:00Limbic System11.032471464529429e-0022003-03-01T00:00:002003-03-01T00:00:00Glutamic Acid11.019633527607934e-0022006-08-01T00:00:002006-08-01T00:00:00Information Storage and Retrieval11.018635004103255e-0022006-06-01T00:00:002006-06-01T00:00:00Qualitative Research11.013908896280363e-0022012-09-19T00:00:002012-09-19T00:00:00Amino Acids11.006345155969612e-0022006-12-01T00:00:002006-12-01T00:00:00Anger19.874440574240749e-0032002-07-01T00:00:002002-07-01T00:00:00Electrocardiography19.729358854877787e-0032013-06-16T00:00:002013-06-16T00:00:00Drug Administration Routes19.655585441878483e-0031999-12-01T00:00:001999-12-01T00:00:00Radiopharmaceuticals19.638626845564772e-0032010-01-06T00:00:002010-01-06T00:00:00Transcriptome19.617081436178772e-0032015-01-14T00:00:002015-01-14T00:00:00Residence Characteristics19.526308530452960e-0032010-02-09T00:00:002010-02-09T00:00:00Stimulation, Chemical19.275413273436723e-0031999-02-13T00:00:001999-02-13T00:00:00Mathematics19.144934415492662e-0032000-05-01T00:00:002000-05-01T00:00:00Models, Psychological19.140415411422765e-0032003-02-01T00:00:002003-02-01T00:00:00Random Allocation19.131511919108007e-0032003-05-01T00:00:002003-05-01T00:00:00Semantics19.088626696340552e-0032003-02-01T00:00:002003-02-01T00:00:00Adaptation, Psychological19.000738395626897e-0032010-02-01T00:00:002010-02-01T00:00:00Genotype18.992723931960558e-0032013-03-15T00:00:002013-03-15T00:00:00Health Surveys18.892361601863300e-0032008-07-24T00:00:002008-07-24T00:00:00Olfactory Pathways18.627945316144071e-0031999-04-01T00:00:001999-04-01T00:00:00Wakefulness18.513301570350868e-0032005-01-01T00:00:002005-01-01T00:00:00Organ Specificity18.249242415095882e-0032002-07-01T00:00:002002-07-01T00:00:00Speech17.902570178540541e-0032002-02-01T00:00:002002-02-01T00:00:00Immunohistochemistry17.891491466634416e-0032010-08-10T00:00:002010-08-10T00:00:00Databases, Factual17.859595697745895e-0032012-09-19T00:00:002012-09-19T00:00:00Smell17.595375647229545e-0031999-04-01T00:00:001999-04-01T00:00:00Postoperative Period17.472031219924458e-0032001-02-01T00:00:002001-02-01T00:00:00Hospitalization17.414199408813451e-0032016-04-18T00:00:002016-04-18T00:00:00Thalamic Nuclei17.367959545078098e-0031996-07-01T00:00:001996-07-01T00:00:00Schizophrenic Psychology17.325686086298451e-0032002-12-01T00:00:002002-12-01T00:00:00Biomarkers, Tumor16.836054934739549e-0032015-10-28T00:00:002015-10-28T00:00:00Copper Sulfate16.787625812289679e-0031994-05-01T00:00:001994-05-01T00:00:00Postpartum Period16.684983122472540e-0032001-10-01T00:00:002001-10-01T00:00:00Computer Graphics16.659682221013809e-0031996-11-01T00:00:001996-11-01T00:00:00Models, Structural16.527712384656518e-0031994-05-01T00:00:001994-05-01T00:00:00Polymorphism, Single Nucleotide16.365934904781342e-0032013-03-15T00:00:002013-03-15T00:00:00In Situ Hybridization16.311368197372025e-0031997-05-29T00:00:001997-05-29T00:00:00Patient Acceptance of Health Care16.262939650778227e-0032008-07-24T00:00:002008-07-24T00:00:00Fear16.236033973406413e-0032002-07-01T00:00:002002-07-01T00:00:00Hypoglycemic Agents16.201188587315592e-0032007-02-08T00:00:002007-02-08T00:00:00Contusions16.157481166696877e-0031994-02-01T00:00:001994-02-01T00:00:00Postoperative Care16.038519987663264e-0031999-12-01T00:00:001999-12-01T00:00:00Biomedical Research15.855370539966158e-0032008-07-24T00:00:002008-07-24T00:00:00Hematoma15.785188661376144e-0031997-06-29T00:00:001997-06-29T00:00:00Infant, Newborn15.635647222693925e-0032012-08-07T00:00:002012-08-07T00:00:00Cricetinae15.592419423185519e-0031995-08-01T00:00:001995-08-01T00:00:00Copper15.387950943102982e-0031994-05-01T00:00:001994-05-01T00:00:00United States15.327717629890454e-0032019-10-18T00:00:002019-10-18T00:00:00Antigens, Viral15.326624077306504e-0031995-08-01T00:00:001995-08-01T00:00:00Phenotype15.284903658922069e-0032009-04-15T00:00:002009-04-15T00:00:00Swine15.255344488946340e-0032000-08-01T00:00:002000-08-01T00:00:00Surface Properties15.112692876322715e-0031994-02-01T00:00:001994-02-01T00:00:00Energy Metabolism14.986820810860559e-0032001-08-01T00:00:002001-08-01T00:00:00Video Recording14.933660973295110e-0031995-10-01T00:00:001995-10-01T00:00:00Edema14.910561231704575e-0031994-02-01T00:00:001994-02-01T00:00:00Mental Disorders14.773059380130826e-0032010-02-01T00:00:002010-02-01T00:00:00Monitoring, Physiologic14.301208149827696e-0031995-10-01T00:00:001995-10-01T00:00:00Prostheses and Implants14.002611545619103e-0031994-02-01T00:00:001994-02-01T00:00:00Sex Factors13.864770256539927e-0032000-09-01T00:00:002000-09-01T00:00:00Diagnosis, Differential13.833326706284881e-0032001-10-01T00:00:002001-10-01T00:00:00Cerebral Hemorrhage13.648545850418867e-0031997-06-29T00:00:001997-06-29T00:00:00Infant13.488691110808165e-0032007-10-05T00:00:002007-10-05T00:00:00Epilepsy13.476615096988487e-0032000-10-01T00:00:002000-10-01T00:00:00Gene Expression13.474207552516579e-0031997-05-29T00:00:001997-05-29T00:00:00RNA, Messenger12.872630186482738e-0031997-05-29T00:00:001997-05-29T00:00:00Cell Line12.758653680273765e-0031995-08-01T00:00:001995-08-01T00:00:00Ron Alterman, M.D.RonAlterman

Beth Israel Deaconess Medical CenterNeurosurgery - Suite 3B110 Francis StreetBoston, MA 02215617/632-7246

2BIDMCBeth Israel Deaconess Medical CenterNeurosurgeryProfessor of NeurosurgeryFull Professor1BIDMCBeth Israel Deaconess Medical CenterNeurosurgeryHead of the Department of Neurosurgery at Beth Israel-Deaconess Medical CenterOther Facultyhttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=1234117http://www.ncbi.nlm.nih.gov/pubmed/40838518Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease. Alzheimers Dement. 2025 Aug; 21(8):e70498.Howard CW, Reich M, Luo L, Pacheco-Barrios N, Alterman R, Rios AS, Guo M, Luo Z, Friedrich H, Pines A, Montaser-Kouhsari L, Drew W, Hart L, Meyer G, Rajamani N, Friedrich MU, Milanese V, Lozano A, Picht T, Faust K, Horn A, Fox MD. Alzheimers Dement2025 Aug21(8):e70498http://www.ncbi.nlm.nih.gov/pubmed/40388898Battery Longevity in Deep Brain Stimulation for Parkinson's Disease. Stereotact Funct Neurosurg. 2025; 103(4):227-235.Yazdanian F, Enriquez-Marulanda A, Dehmamy N, Mortezaei A, Hassan T, Shils JL, Alterman RL. Stereotact Funct Neurosurg2025103(4):227-235http://www.ncbi.nlm.nih.gov/pubmed/39951908Meaningful work, organizational commitment and administrative burden among attending neurosurgeons. Neurochirurgie. 2025 Mar; 71(2):101645.Mackel CE, Saway BF, Alterman RL, Spiotta AM, Sweet JA, Davis RB, Williamson T, Stippler M. Neurochirurgie2025 Mar71(2):101645http://www.ncbi.nlm.nih.gov/pubmed/38906476Factors Associated with Extended Hospitalization in Patients Who Had Adjuvant Middle Meningeal Artery Embolization After Conventional Surgery for Chronic Subdural Hematomas. World Neurosurg. 2024 09; 189:e168-e176.Filo J, Salih M, Alwakaa O, Ramirez-Velandia F, Shutran M, Vega RA, Stippler M, Papavassiliou E, Alterman RL, Thomas A, Taussky P, Moore J, Ogilvy CS. World Neurosurg2024 09189:e168-e176http://www.ncbi.nlm.nih.gov/pubmed/37831227Surgery in octogenarians with intracranial meningiomas improves functional outcome at 1 year. Acta Neurochir (Wien). 2023 12; 165(12):4183-4189.Filippidis AS, Phillips KR, Lopez-Rivera V, Enriquez-Marulanda A, Mackel CE, Alterman RL, Vega RA. Acta Neurochir (Wien)2023 12165(12):4183-4189http://www.ncbi.nlm.nih.gov/pubmed/37039586Targeting Accuracy of the Leksell Vantage Stereotactic System for Deep Brain Stimulation Surgery: A Retrospective Review. Oper Neurosurg. 2023 06 01; 24(6):602-609.Phillips KR, Mackel CE, Alterman RL. Oper Neurosurg2023 06 0124(6):602-609http://www.ncbi.nlm.nih.gov/pubmed/37151152Intracranial Metastasis of Extracranial Chondrosarcoma: Systematic Review With Illustrative Case. Brain Tumor Res Treat. 2023 Apr; 11(2):103-113.Mackel CE, Rosenberg H, Varma H, Uhlmann EJ, Vega RA, Alterman RL. Brain Tumor Res Treat2023 Apr11(2):103-113http://www.ncbi.nlm.nih.gov/pubmed/37123627Predictors of extended length of stay related to craniotomy for tumor resection. World Neurosurg X. 2023 Jul; 19:100176.Phillips KR, Enriquez-Marulanda A, Mackel C, Ogbonna J, Moore JM, Vega RA, Alterman RL. World Neurosurg X2023 Jul19:100176http://www.ncbi.nlm.nih.gov/pubmed/36921243Outcome of Chronic Subdural Hematoma Intervention in Patients on Long-Term Antiplatelet Therapy-A Propensity Score Matched Analysis. Neurosurgery. 2023 09 01; 93(3):586-591.Salih M, Young M, Garcia A, Stippler M, Papavassiliou E, Alterman RL, Thomas AJ, Taussky P, Moore J, Ogilvy CS. Neurosurgery2023 09 0193(3):586-591http://www.ncbi.nlm.nih.gov/pubmed/36701570Complications Related to Deep Brain Stimulation Lead Implantation: A Single-Surgeon Case Series. Oper Neurosurg. 2023 03 01; 24(3):276-282.Powers AY, Nguyen M, Phillips K, Mackel CE, Alterman RL. Oper Neurosurg2023 03 0124(3):276-282http://www.ncbi.nlm.nih.gov/pubmed/35985470Effective deep brain stimulation lead revision guided by computerized lead localization: A case report. Brain Stimul. 2022 Sep-Oct; 15(5):1125-1127.Nguyen M, Ali SM, Alterman RL, Luo L. Brain Stimul2022 Sep-Oct15(5):1125-1127http://www.ncbi.nlm.nih.gov/pubmed/35319531Moral Distress and Moral Injury Among Attending Neurosurgeons: A National Survey. Neurosurgery. 2022 07 01; 91(1):59-65.Mackel CE, Alterman RL, Buss MK, Reynolds RM, Fox WC, Spiotta AM, Davis RB, Stippler M. Neurosurgery2022 07 0191(1):59-65http://www.ncbi.nlm.nih.gov/pubmed/34850056Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology. J Neuropathol Exp Neurol. 2021 12 29; 80(12):1117-1124.Uhlmann EJ, Rabinovsky R, Varma H, El Fatimy R, Kasper EM, Moore JM, Vega RA, Thomas AJ, Alterman RL, Stippler M, Anderson MP, Uhlmann EN, Kipper FC, Krichevsky AM. J Neuropathol Exp Neurol2021 12 2980(12):1117-1124http://www.ncbi.nlm.nih.gov/pubmed/34690908Short- and Long-Term Effects of DBS on Gait in Parkinson's Disease. Front Neurol. 2021; 12:688760.Brozova H, Barnaure I, Ruzicka E, Stochl J, Alterman R, Tagliati M. Front Neurol202112:688760http://www.ncbi.nlm.nih.gov/pubmed/34171921Middle Meningeal Artery Embolization Versus Conventional Treatment of Chronic Subdural Hematomas. Neurosurgery. 2021 08 16; 89(3):486-495.Enriquez-Marulanda A, Gomez-Paz S, Salem MM, Mallick A, Motiei-Langroudi R, Arle JE, Stippler M, Papavassiliou E, Alterman RL, Ogilvy CS, Moore JM, Thomas AJ. Neurosurgery2021 08 1689(3):486-495http://www.ncbi.nlm.nih.gov/pubmed/34298519Cellular transplantation for Parkinson's disease: a strategy whose time has passed. J Neurosurg. 2021 12 01; 135(6):1898-1902.Alterman RL. J Neurosurg2021 12 01135(6):1898-1902http://www.ncbi.nlm.nih.gov/pubmed/33913497Letter: Randomized Trial of Unilateral Focused Ultrasound Subthalamotomy for Parkinson Disease. Neurosurgery. 2021 06 15; 89(1):E95-E96.Alterman RL, Schulder M. Neurosurgery2021 06 1589(1):E95-E96http://www.ncbi.nlm.nih.gov/pubmed/34221568Parkinsonism reversed from treatment of pineal non-germinomatous germ cell tumor. Surg Neurol Int. 2021; 12:237.Cole SM, Sarangi S, Einstein D, McMasters M, Alterman R, Bruce J, Hertan L, Shih HA, Wong ET. Surg Neurol Int202112:237http://www.ncbi.nlm.nih.gov/pubmed/33289520Letter: Stem Cell Transplantation for Parkinson Disease: Déjà Vu All Over Again? Neurosurgery. 2021 01 13; 88(2):E216-E217.Alterman RL. Neurosurgery2021 01 1388(2):E216-E217http://www.ncbi.nlm.nih.gov/pubmed/33339691GCB-type is a favorable prognostic factor in primary CNS diffuse large B-cell lymphomas. J Clin Neurosci. 2021 Jan; 83:49-55.Marcus C, Maragkos GA, Alterman RL, Uhlmann E, Pihan G, Varma H. J Clin Neurosci2021 Jan83:49-55http://www.ncbi.nlm.nih.gov/pubmed/33303306A tale of two tinnituses: Does hearing status influence central tinnitus localization? Med Hypotheses. 2021 Jan; 146:110444.Naples JG, Sadler S, Watson N, Miller LE, Alterman RL. Med Hypotheses2021 Jan146:110444http://www.ncbi.nlm.nih.gov/pubmed/32710790Risk Factors for Wire Fracture or Tethering in Deep Brain Stimulation: A 15-Year Experience. Oper Neurosurg. 2020 11 16; 19(6):708-714.Mackel CE, Papavassiliou E, Alterman RL. Oper Neurosurg2020 11 1619(6):708-714http://www.ncbi.nlm.nih.gov/pubmed/31841105A high-grade glioma with SOS1 amplification. Clin Neuropathol. 2020 May/Jun; 39(3):126-134.Vidal B, Bryke C, Hsu N, Alterman R, Yeo AT, Charest A, Varma H. Clin Neuropathol2020 May/Jun39(3):126-134http://www.ncbi.nlm.nih.gov/pubmed/31883483Factors Affecting the Diagnostic Yield of Frame-Based Stereotactic Intracranial Biopsies. World Neurosurg. 2020 Mar; 135:e695-e701.Maragkos GA, Penumaka A, Ahrendsen JT, Salem MM, Nelton EB, Alterman RL. World Neurosurg2020 Mar135:e695-e701http://www.ncbi.nlm.nih.gov/pubmed/30265326Factors Predicting the Need for Surgery of the Opposite Side After Unilateral Evacuation of Bilateral Chronic Subdural Hematomas. Neurosurgery. 2019 11 01; 85(5):648-655.Motiei-Langroudi R, Thomas AJ, Ascanio L, Alturki A, Papavassiliou E, Kasper EM, Arle J, Alterman RL, Ogilvy CS, Stippler M. Neurosurgery2019 11 0185(5):648-655http://www.ncbi.nlm.nih.gov/pubmed/31543803Efficacy of Deep Brain Stimulation in a Patient with Genetically Confirmed Chorea-Acanthocytosis. Case Rep Neurol. 2019 May-Aug; 11(2):199-204.Richard A, Hsu J, Baum P, Alterman R, Simon DK. Case Rep Neurol2019 May-Aug11(2):199-204http://www.ncbi.nlm.nih.gov/pubmed/30641839Factors influencing the presence of hemiparesis in chronic subdural hematoma. J Neurosurg. 2019 12 01; 131(6):1926-1930.Motiei-Langroudi R, Alterman RL, Stippler M, Phan K, Alturki AY, Papavassiliou E, Kasper EM, Arle J, Ogilvy CS, Thomas AJ. J Neurosurg2019 12 01131(6):1926-1930http://www.ncbi.nlm.nih.gov/pubmed/30011048In Reply: Commentary: Utilization of Quantitative Susceptibility Mapping for Direct Targeting of the Subthalamic Nucleus During Deep Brain Stimulation Surgery. Oper Neurosurg. 2018 10 01; 15(4):45.Alterman RL, Fleishman A, Ngo L. Oper Neurosurg2018 10 0115(4):45http://www.ncbi.nlm.nih.gov/pubmed/30838292Genetic Subtypes and Deep Brain Stimulation in Dystonia. Mov Disord Clin Pract. 2018 Jul-Aug; 5(4):357-360.Alterman RL, Filippidis AS. Mov Disord Clin Pract2018 Jul-Aug5(4):357-360http://www.ncbi.nlm.nih.gov/pubmed/30153389Sustained quality-of-life improvements over 10 years after deep brain stimulation for dystonia. Mov Disord. 2018 07; 33(7):1160-1167.Hogg E, During E, E Tan E, Athreya K, Eskenazi J, Wertheimer J, Mamelak AN, Alterman RL, Tagliati M. Mov Disord2018 0733(7):1160-1167http://www.ncbi.nlm.nih.gov/pubmed/29538685Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients With Parkinson's Disease: Executive Summary. Neurosurgery. 2018 06 01; 82(6):753-756.Rughani A, Schwalb JM, Sidiropoulos C, Pilitsis J, Ramirez-Zamora A, Sweet JA, Mittal S, Espay AJ, Martinez JG, Abosch A, Eskandar E, Gross R, Alterman R, Hamani C. Neurosurgery2018 06 0182(6):753-756http://www.ncbi.nlm.nih.gov/pubmed/28633383Commentary: Utilization of Quantitative Susceptibility Mapping for Direct Targeting of the Subthalamic Nucleus During Deep Brain Stimulation Surgery. Oper Neurosurg. 2018 04 01; 14(4):420-421.Alterman RL. Oper Neurosurg2018 04 0114(4):420-421http://www.ncbi.nlm.nih.gov/pubmed/28962000Stereotactic Drainage of Brainstem Abscess With the BrainLab Varioguide™ System and the Airo™ Intraoperative CT Scanner: Technical Case Report. Oper Neurosurg. 2018 04 01; 14(4):E46-E50.Almeida CC, Uzuner A, Alterman RL. Oper Neurosurg2018 04 0114(4):E46-E50http://www.ncbi.nlm.nih.gov/pubmed/29243977Factors predicting reoperation of chronic subdural hematoma following primary surgical evacuation. J Neurosurg. 2018 11 01; 129(5):1143-1150.Motiei-Langroudi R, Stippler M, Shi S, Adeeb N, Gupta R, Griessenauer CJ, Papavassiliou E, Kasper EM, Arle J, Alterman RL, Ogilvy CS, Thomas AJ. J Neurosurg2018 11 01129(5):1143-1150http://www.ncbi.nlm.nih.gov/pubmed/29158092Medical Malpractice in Neurosurgery: A Comprehensive Analysis. World Neurosurg. 2018 Feb; 110:e552-e559.Thomas R, Gupta R, Griessenauer CJ, Moore JM, Adeeb N, Motiei-Langroudi R, Guidal B, Agarwal N, Alterman RL, Friedlander RM, Ogilvy CS, Thomas AJ. 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Chronic69.019958590773203e-0012017-12-15T00:00:002024-06-19T00:00:00Electric Power Supplies18.659041540352688e-0012025-05-19T00:00:002025-05-19T00:00:00Thalamus57.231109950683174e-0011997-08-01T00:00:002017-03-15T00:00:00Essential Tremor26.635125429891431e-0012010-06-01T00:00:002016-12-01T00:00:00Dystonic Disorders76.420651884244004e-0012008-06-20T00:00:002017-02-03T00:00:00Eikenella corrodens15.696812266949262e-0012018-04-01T00:00:002018-04-01T00:00:00Electric Stimulation Therapy55.564470155383985e-0011999-01-01T00:00:002010-06-01T00:00:00Tinnitus15.523986763861899e-0012020-12-03T00:00:002020-12-03T00:00:00Neurosurgical Procedures65.094146695395784e-0012010-10-11T00:00:002024-06-19T00:00:00Drainage34.975994221793108e-0012018-04-01T00:00:002023-03-15T00:00:00Gram-Negative Bacterial Infections14.707748545863263e-0012018-04-01T00:00:002018-04-01T00:00:00Cerebellar Diseases13.963803950778316e-0012015-12-25T00:00:002015-12-25T00:00:00Hearing Loss13.900590799143174e-0012020-12-03T00:00:002020-12-03T00:00:00Brain Stem13.768405950383872e-0012018-04-01T00:00:002018-04-01T00:00:00Brain Diseases13.248769059527696e-0012019-12-25T00:00:002019-12-25T00:00:00Lateral Ventricles13.230679738302865e-0012011-08-01T00:00:002011-08-01T00:00:00Radiography, Interventional13.198990964018363e-0012018-04-01T00:00:002018-04-01T00:00:00Surgeons13.196276950481620e-0012022-11-28T00:00:002022-11-28T00:00:00Levodopa43.167155464087197e-0011997-01-01T00:00:002010-11-01T00:00:00Magnetic Resonance Imaging193.111141624057607e-0011995-10-01T00:00:002025-08-01T00:00:00Radiation Protection13.082974836603747e-0012014-03-27T00:00:002014-03-27T00:00:00Neurturin33.041630214524354e-0012010-10-20T00:00:002015-06-10T00:00:00Neuronavigation23.018122033362206e-0012009-04-01T00:00:002010-06-01T00:00:00Confusion13.015287853080068e-0012011-08-01T00:00:002011-08-01T00:00:00Therapy, Computer-Assisted22.955518429588300e-0011997-01-01T00:00:002004-09-01T00:00:00Surgery, Computer-Assisted12.892418103005958e-0012017-03-15T00:00:002017-03-15T00:00:00Imaging, Three-Dimensional22.888922788777304e-0012018-04-01T00:00:002023-04-11T00:00:00Monitoring, Intraoperative42.886453685861444e-0011995-10-01T00:00:002015-01-01T00:00:00Ultrasonography, Interventional12.805702721570350e-0012017-03-15T00:00:002017-03-15T00:00:00Humans912.559813702405059e-0011990-04-15T00:00:002025-08-01T00:00:00Neurosurgeons32.558035075643486e-0012017-11-20T00:00:002025-02-13T00:00:00Retrospective Studies262.514128399763388e-0011995-10-01T00:00:002025-05-19T00:00:00Radiation Injuries12.452564217016296e-0012014-03-27T00:00:002014-03-27T00:00:00Meningeal Arteries22.439644178120622e-0012021-08-16T00:00:002024-06-19T00:00:00Antiparkinson Agents32.377011623009580e-0011997-01-01T00:00:002004-07-15T00:00:00Dyskinesia, Drug-Induced22.348459401994056e-0011997-01-01T00:00:002004-07-15T00:00:00Prosthesis Implantation12.342405385014182e-0012010-06-01T00:00:002010-06-01T00:00:00Neuroimaging12.314542776333335e-0012018-04-01T00:00:002018-04-01T00:00:00Cerebral Hemorrhage22.265820235655501e-0011999-02-01T00:00:002015-12-25T00:00:00Brain Mapping52.223508259426617e-0011997-01-01T00:00:002017-02-03T00:00:00Neurosurgery22.143340521511280e-0012017-11-20T00:00:002025-02-13T00:00:00Anesthesia12.062493605624937e-0012015-01-01T00:00:002015-01-01T00:00:00Treatment Outcome292.035005644350851e-0011995-10-01T00:00:002023-10-13T00:00:00Meningioma21.971598203507188e-0012021-12-29T00:00:002023-10-13T00:00:00Meningeal Neoplasms21.910871000234964e-0012021-12-29T00:00:002023-10-13T00:00:00Embolization, Therapeutic21.887111632058300e-0012021-08-16T00:00:002024-06-19T00:00:00Nervous System Diseases11.887023485984421e-0012013-07-01T00:00:002013-07-01T00:00:00Substantia Nigra21.865074189965983e-0012013-04-10T00:00:002015-06-10T00:00:00Obsessive-Compulsive Disorder11.836817975503511e-0012011-10-27T00:00:002011-10-27T00:00:00Brain Injuries11.831255490150910e-0012014-03-27T00:00:002014-03-27T00:00:00Dopamine Agonists11.772697451930965e-0012004-07-15T00:00:002004-07-15T00:00:00Brain91.750734858173493e-0011997-10-01T00:00:002019-12-25T00:00:00Electrophysiology31.740001465530894e-0011997-10-01T00:00:002001-01-01T00:00:00Methylmethacrylate11.724629202041253e-0012001-02-01T00:00:002001-02-01T00:00:00Image Interpretation, Computer-Assisted11.684049800895481e-0012014-03-27T00:00:002014-03-27T00:00:00Middle Aged391.682284790056494e-0011995-10-01T00:00:002025-08-01T00:00:00Job Satisfaction11.662215674420380e-0012025-02-13T00:00:002025-02-13T00:00:00Bone Wires11.630752804683029e-0012020-11-16T00:00:002020-11-16T00:00:00SOS1 Protein11.611972595571441e-0012020-05-01T00:00:002020-05-01T00:00:00Male461.605122305572432e-0011995-10-01T00:00:002025-08-01T00:00:00Equipment Design41.604677896566783e-0012001-01-01T00:00:002018-04-01T00:00:00Postoperative Complications71.548977511206366e-0011997-01-01T00:00:002024-06-19T00:00:00Tomography, X-Ray Computed31.530842338540749e-0011995-10-01T00:00:002018-04-01T00:00:00Depressive Disorder11.494902022384785e-0012011-10-27T00:00:002011-10-27T00:00:00Bone Cements11.475972476612069e-0012001-02-01T00:00:002001-02-01T00:00:00Ventral Thalamic Nuclei11.440730839512966e-0011999-01-01T00:00:001999-01-01T00:00:00Sound11.439131368365247e-0012020-12-03T00:00:002020-12-03T00:00:00Dependovirus31.416869688840714e-0012010-10-20T00:00:002015-06-10T00:00:00Focal Infection, Dental11.406506382973895e-0012018-04-01T00:00:002018-04-01T00:00:00Length of Stay21.382255146379482e-0012019-12-25T00:00:002024-06-19T00:00:00Female391.364892946944123e-0011995-10-01T00:00:002025-08-01T00:00:00Neurologic Examination31.358227557910570e-0011997-01-01T00:00:002013-02-11T00:00:00Paresis11.355652983889296e-0012019-01-11T00:00:002019-01-11T00:00:00Dominance, Cerebral21.354784889849160e-0011997-01-01T00:00:002011-10-05T00:00:00Germinal Center11.342322347062932e-0012020-12-16T00:00:002020-12-16T00:00:00Aged251.311267902909729e-0011995-10-01T00:00:002025-08-01T00:00:00Preoperative Care21.302054521689249e-0011999-01-01T00:00:002015-01-01T00:00:00Burnout, Professional21.279295121529409e-0012022-03-25T00:00:002025-02-13T00:00:00Genetic Therapy31.268868759236869e-0012010-10-20T00:00:002015-06-10T00:00:00Putamen21.244668097970661e-0012010-10-20T00:00:002015-06-10T00:00:00Hearing11.243897792515097e-0012020-12-03T00:00:002020-12-03T00:00:00Tumor Cells, Cultured31.221949198603155e-0011990-04-15T00:00:002021-12-29T00:00:00Acoustic Stimulation11.217977804625241e-0012020-12-03T00:00:002020-12-03T00:00:00Brain Neoplasms21.214013012911507e-0012017-03-15T00:00:002020-05-01T00:00:00Cerebral Ventriculography11.196701203537442e-0011995-10-01T00:00:001995-10-01T00:00:00Operative Time11.191917102534655e-0012019-12-25T00:00:002019-12-25T00:00:00Intraoperative Complications21.183491666799246e-0012010-06-01T00:00:002015-01-01T00:00:00Blood Loss, Surgical11.151111635737591e-0012019-12-25T00:00:002019-12-25T00:00:00Astrocytoma11.149364602339446e-0012020-05-01T00:00:002020-05-01T00:00:00Atlases as Topic11.120327592401181e-0012017-02-03T00:00:002017-02-03T00:00:00Thalamic Nuclei11.119141020630945e-0011995-10-01T00:00:001995-10-01T00:00:00Biopsy, Needle11.105583999910729e-0012019-12-25T00:00:002019-12-25T00:00:00Axonal Transport11.091773061849131e-0012015-06-10T00:00:002015-06-10T00:00:00Cerebrovascular Circulation21.065316806356605e-0012011-10-05T00:00:002017-04-19T00:00:00Cell Culture Techniques11.050876185838418e-0012021-12-29T00:00:002021-12-29T00:00:00Dopamine11.022769272183368e-0012021-01-13T00:00:002021-01-13T00:00:00Randomized Controlled Trials as Topic11.020903145385158e-0012011-07-01T00:00:002011-07-01T00:00:00Speech29.961017167932570e-0022011-10-05T00:00:002016-03-19T00:00:00Lymphoma, Non-Hodgkin19.919126205930448e-0022020-12-16T00:00:002020-12-16T00:00:00Mental Disorders29.695399293330337e-0022001-12-01T00:00:002011-10-27T00:00:00Malpractice19.538843161323522e-0022017-11-20T00:00:002017-11-20T00:00:00Hippocampus19.398512548751019e-0022025-08-01T00:00:002025-08-01T00:00:00Disability Evaluation29.261833311964723e-0022007-06-06T00:00:002011-09-23T00:00:00Stem Cell Transplantation19.248162334325322e-0022021-01-13T00:00:002021-01-13T00:00:00Implantable Neurostimulators19.244835119093395e-0022013-04-12T00:00:002013-04-12T00:00:00Tourette Syndrome19.109489814605581e-0022015-05-25T00:00:002015-05-25T00:00:00Patient Selection69.075540260379469e-0021997-01-01T00:00:002011-08-01T00:00:00Anti-Dyskinesia Agents19.006916757014664e-0022011-09-23T00:00:002011-09-23T00:00:00Central Nervous System Neoplasms18.935325069100329e-0022020-12-16T00:00:002020-12-16T00:00:00Tics18.836542593791689e-0022012-05-24T00:00:002012-05-24T00:00:00Pediatrics18.713129233162366e-0022007-06-06T00:00:002007-06-06T00:00:00Reoperation28.655864823853354e-0022017-12-15T00:00:002019-11-01T00:00:00Fatal Outcome18.563315479861484e-0022015-12-25T00:00:002015-12-25T00:00:00Platelet Aggregation Inhibitors18.360749841969173e-0022023-03-15T00:00:002023-03-15T00:00:00Muscle Rigidity18.355220174345153e-0022010-11-01T00:00:002010-11-01T00:00:00Adult228.039654194041952e-0021995-10-01T00:00:002025-02-13T00:00:00Lymphoma, Large B-Cell, Diffuse17.987004139421879e-0022020-12-16T00:00:002020-12-16T00:00:00International Cooperation17.334465805567017e-0022015-05-25T00:00:002015-05-25T00:00:00Child107.253590402739796e-0021995-10-01T00:00:002017-11-20T00:00:00Electric Impedance17.128638595292501e-0022013-04-12T00:00:002013-04-12T00:00:00Adolescent127.069477847433803e-0021995-10-01T00:00:002014-06-18T00:00:00Sample Size16.918317136024810e-0022011-07-01T00:00:002011-07-01T00:00:00Treatment Failure36.741060164647938e-0022005-06-13T00:00:002010-10-11T00:00:00Cognition16.573742828528030e-0022025-08-01T00:00:002025-08-01T00:00:00Glioma36.415398454507044e-0021990-04-15T00:00:002020-05-01T00:00:00Age of Onset26.409041021903934e-0022009-04-01T00:00:002011-09-23T00:00:00B-Lymphocytes16.374125841693164e-0022020-12-16T00:00:002020-12-16T00:00:00Young Adult96.325488552190658e-0022009-04-01T00:00:002018-07-01T00:00:00Prognosis56.310992922940811e-0022008-06-20T00:00:002020-12-16T00:00:00Apoptosis Regulatory Proteins16.153973286153204e-0022011-09-23T00:00:002011-09-23T00:00:00Models, Neurological16.129554444922046e-0022014-06-18T00:00:002014-06-18T00:00:00Cochlear Implants16.081303298419932e-0022010-06-01T00:00:002010-06-01T00:00:00Combined Modality Therapy16.067774230709613e-0022018-04-01T00:00:002018-04-01T00:00:00Electric Stimulation36.038982585384529e-0021996-01-01T00:00:002001-01-01T00:00:00Aged, 80 and over85.815048444928842e-0022005-06-13T00:00:002024-06-19T00:00:00Genetic Vectors15.762636183823916e-0022015-06-10T00:00:002015-06-10T00:00:00Dose-Response Relationship, Radiation15.631895513990105e-0022007-02-15T00:00:002007-02-15T00:00:00Molecular Chaperones35.528400462044502e-0022009-04-01T00:00:002018-07-01T00:00:00Radiation Dosage15.517423146869500e-0022014-03-27T00:00:002014-03-27T00:00:00Review Literature as Topic15.514467946944838e-0022007-01-01T00:00:002007-01-01T00:00:00Risk Factors55.204218341595145e-0022005-07-12T00:00:002024-06-19T00:00:00Octogenarians15.175928215110463e-0022023-10-13T00:00:002023-10-13T00:00:00Stress Disorders, Post-Traumatic15.172297065651250e-0022022-03-25T00:00:002022-03-25T00:00:00Follow-Up Studies65.168248565468777e-0022007-02-15T00:00:002013-04-10T00:00:00Mutation35.057541154531810e-0022011-09-23T00:00:002020-05-01T00:00:00Double-Blind Method34.981886754918168e-0022010-10-20T00:00:002015-06-10T00:00:00Alzheimer Disease14.972466028462574e-0022025-08-01T00:00:002025-08-01T00:00:00Gait14.940555685023971e-0022009-02-24T00:00:002009-02-24T00:00:00Genetic Testing14.927967116162248e-0022017-02-03T00:00:002017-02-03T00:00:00Equipment Failure Analysis14.556401864534312e-0022004-09-01T00:00:002004-09-01T00:00:00Data Interpretation, Statistical14.519216128072676e-0022011-09-23T00:00:002011-09-23T00:00:00Psychosurgery14.368904507988478e-0022001-12-01T00:00:002001-12-01T00:00:00Age Factors34.249448907617957e-0022005-07-12T00:00:002025-08-01T00:00:00Severity of Illness Index54.202693238364268e-0022007-06-06T00:00:002012-01-11T00:00:00Diagnosis, Differential14.111895799916385e-0022015-12-25T00:00:002015-12-25T00:00:00Recovery of Function14.074196455705522e-0022011-03-02T00:00:002011-03-02T00:00:00Time Factors54.037147967015976e-0021999-02-01T00:00:002011-10-05T00:00:00Tomography, Emission-Computed34.036907493016058e-0021997-01-01T00:00:001997-10-01T00:00:00Referral and Consultation24.022783648940589e-0022005-06-13T00:00:002011-08-01T00:00:00Online Systems13.947908177051342e-0022001-01-01T00:00:002001-01-01T00:00:00Leg13.829852929939422e-0022004-07-15T00:00:002004-07-15T00:00:00Device Removal13.739857633748547e-0022004-07-15T00:00:002004-07-15T00:00:00Longitudinal Studies23.687062543534847e-0022011-03-01T00:00:002018-07-01T00:00:00Morals13.658057422384956e-0022022-03-25T00:00:002022-03-25T00:00:00Anti-Bacterial Agents13.657486118396431e-0022018-04-01T00:00:002018-04-01T00:00:00Comparative Genomic Hybridization13.649043984253788e-0022020-05-01T00:00:002020-05-01T00:00:00Child, Preschool23.635239528209048e-0022011-03-01T00:00:002013-07-01T00:00:00Sensitivity and Specificity13.629550394744099e-0022014-03-27T00:00:002014-03-27T00:00:00Reproducibility of Results23.624390905792831e-0022013-04-12T00:00:002014-03-27T00:00:00Basal Ganglia23.579645773899567e-0021996-01-01T00:00:001999-03-01T00:00:00Remission Induction13.560164931167606e-0022004-07-15T00:00:002004-07-15T00:00:00Employment13.478562951820698e-0022025-02-13T00:00:002025-02-13T00:00:00DNA13.407742416334190e-0022011-09-23T00:00:002011-09-23T00:00:00Nuclear Proteins13.149201877772420e-0022011-09-23T00:00:002011-09-23T00:00:00Evaluation Studies as Topic13.130921282313586e-0021999-01-01T00:00:001999-01-01T00:00:00Electrodes13.116296014503286e-0021999-02-01T00:00:001999-02-01T00:00:00Quality of Life13.014583007985441e-0022018-07-01T00:00:002018-07-01T00:00:00Gestures12.946376848843927e-0022016-03-19T00:00:002016-03-19T00:00:00Speech Production Measurement12.937960357086866e-0022016-03-19T00:00:002016-03-19T00:00:00Research Design12.865140747368954e-0022011-07-01T00:00:002011-07-01T00:00:00Clinical Trials as Topic12.790167985153897e-0022011-07-01T00:00:002011-07-01T00:00:00Propensity Score12.699159780687705e-0022023-03-15T00:00:002023-03-15T00:00:00DNA-Binding Proteins12.691999200454326e-0022011-09-23T00:00:002011-09-23T00:00:00Clopidogrel12.691113494124765e-0022017-12-15T00:00:002017-12-15T00:00:00Motor Activity32.572220192445493e-0021996-01-01T00:00:002011-10-05T00:00:00Signal Processing, Computer-Assisted12.560667890773547e-0022001-01-01T00:00:002001-01-01T00:00:00Principal Component Analysis12.559336638227926e-0022017-04-19T00:00:002017-04-19T00:00:00Action Potentials12.504484693640715e-0022001-01-01T00:00:002001-01-01T00:00:00Disease Progression12.482074905902426e-0022010-11-01T00:00:002010-11-01T00:00:00Statistics, Nonparametric12.403523405661079e-0022018-07-01T00:00:002018-07-01T00:00:00Neoplasm Grading12.361732509460202e-0022020-05-01T00:00:002020-05-01T00:00:00User-Computer Interface12.361141923415746e-0021999-01-01T00:00:001999-01-01T00:00:00Myoclonus12.333731894559065e-0022013-02-11T00:00:002013-02-11T00:00:00Microinjections12.315551390251495e-0022013-04-10T00:00:002013-04-10T00:00:00Neural Networks, Computer12.272088803990110e-0022001-01-01T00:00:002001-01-01T00:00:00Surveys and Questionnaires22.207211138001706e-0022022-03-25T00:00:002025-02-13T00:00:00Dyskinesias12.141809286635514e-0022012-01-11T00:00:002012-01-11T00:00:00Killer Cells, Lymphokine-Activated12.076711959217643e-0021990-07-01T00:00:001990-07-01T00:00:00Phorbol Esters12.045627999344959e-0021990-07-01T00:00:001990-07-01T00:00:00Major Depressive Disorder12.037851541105898e-0022008-05-01T00:00:002008-05-01T00:00:00Proto-Oncogene Proteins B-raf11.975115291608212e-0022020-05-01T00:00:002020-05-01T00:00:00Image Processing, Computer-Assisted21.869846424853885e-0021995-10-01T00:00:002017-04-19T00:00:00Warfarin11.866027201002906e-0022017-12-15T00:00:002017-12-15T00:00:00Positron-Emission Tomography21.712437225663506e-0022011-10-05T00:00:002017-04-19T00:00:00Gene Transfer Techniques11.691536287817063e-0022013-04-10T00:00:002013-04-10T00:00:00Neurons21.590938978181581e-0021996-01-01T00:00:001997-08-01T00:00:00Aging11.466948613635451e-0022005-07-12T00:00:002005-07-12T00:00:00Vagus Nerve11.414640940701574e-0022008-05-01T00:00:002008-05-01T00:00:00Cognition Disorders11.360116413434554e-0022018-07-01T00:00:002018-07-01T00:00:00Fibroblast Growth Factors11.321986197317026e-0021990-04-15T00:00:001990-04-15T00:00:00Hospitalization11.306165309905526e-0022024-06-19T00:00:002024-06-19T00:00:00Neuropsychological Tests11.268681272383707e-0021997-01-01T00:00:001997-01-01T00:00:00Neurology11.263286600590664e-0022011-08-01T00:00:002011-08-01T00:00:00Multiple Sclerosis11.252290902472381e-0021999-01-01T00:00:001999-01-01T00:00:00Animals21.224363938567563e-0022011-07-01T00:00:002015-05-25T00:00:00Electroconvulsive Therapy11.194366712398793e-0022008-05-01T00:00:002008-05-01T00:00:00Equipment Failure11.182413584887868e-0022005-06-13T00:00:002005-06-13T00:00:00Software11.176601835092954e-0021997-01-01T00:00:001997-01-01T00:00:00Analysis of Variance11.167890667946565e-0022010-10-20T00:00:002010-10-20T00:00:00Blood Glucose11.142946057383305e-0021997-01-01T00:00:001997-01-01T00:00:00Feasibility Studies11.098921335842636e-0022013-04-10T00:00:002013-04-10T00:00:00Receptors, Cell Surface11.046555595297114e-0021990-04-15T00:00:001990-04-15T00:00:00Incidence19.976156473924913e-0031999-02-01T00:00:001999-02-01T00:00:00Electroencephalography19.664197401615129e-0031995-10-01T00:00:001995-10-01T00:00:00Medication Errors19.425793760290558e-0032005-06-13T00:00:002005-06-13T00:00:00Biomarkers, Tumor19.344309212612969e-0032020-05-01T00:00:002020-05-01T00:00:00Huntington Disease18.751847982461232e-0032005-07-01T00:00:002005-07-01T00:00:00Transcranial Magnetic Stimulation18.599960895998217e-0032008-05-01T00:00:002008-05-01T00:00:00Diagnostic Errors18.419541014049842e-0032005-06-13T00:00:002005-06-13T00:00:00Algorithms17.667436969821383e-0032017-04-19T00:00:002017-04-19T00:00:00Intraoperative Period17.663759176198714e-0031997-08-01T00:00:001997-08-01T00:00:00Glucose27.415514337238429e-0031997-08-01T00:00:001997-10-01T00:00:00Recurrence17.301843257571334e-0032008-05-01T00:00:002008-05-01T00:00:00Speech Disorders16.810836065776935e-0031996-01-01T00:00:001996-01-01T00:00:00Physical Stimulation16.651798546927162e-0031996-01-01T00:00:001996-01-01T00:00:00Practice Patterns, Physicians'16.448786741937262e-0032011-08-01T00:00:002011-08-01T00:00:00Neurons, Afferent16.286552596527485e-0031996-01-01T00:00:001996-01-01T00:00:00Cell Division26.022923095067145e-0031990-04-15T00:00:001990-07-01T00:00:00Consciousness15.992378916787524e-0031997-08-01T00:00:001997-08-01T00:00:00Postoperative Period15.928867157667601e-0031997-10-01T00:00:001997-10-01T00:00:00Phorbol 12,13-Dibutyrate15.198565767330507e-0031990-07-01T00:00:001990-07-01T00:00:00Phorbols15.186546136460734e-0031990-07-01T00:00:001990-07-01T00:00:00Tumor Stem Cell Assay15.060160154363098e-0031990-04-15T00:00:001990-04-15T00:00:00Thymidine15.029848632836085e-0031990-07-01T00:00:001990-07-01T00:00:00Hand14.951795866200779e-0031996-01-01T00:00:001996-01-01T00:00:00Autonomic Nervous System14.919231825097689e-0031996-01-01T00:00:001996-01-01T00:00:00Receptors, Fibroblast Growth Factor14.722598368268518e-0031990-04-15T00:00:001990-04-15T00:00:00Tetradecanoylphorbol Acetate14.678842194693058e-0031990-07-01T00:00:001990-07-01T00:00:00United States14.667627467900888e-0032017-11-20T00:00:002017-11-20T00:00:00Fluorodeoxyglucose F1814.515536917877193e-0031997-10-01T00:00:001997-10-01T00:00:00Molecular Weight14.257927396914010e-0031990-04-15T00:00:001990-04-15T00:00:00Visual Perception14.130257285281567e-0031996-01-01T00:00:001996-01-01T00:00:00Prospective Studies14.012176058741805e-0032012-01-11T00:00:002012-01-11T00:00:00Protein Kinase C13.715022975892985e-0031990-07-01T00:00:001990-07-01T00:00:00Kinetics12.944439266883978e-0031990-04-15T00:00:001990-04-15T00:00:00Recombinant Proteins12.573694819549137e-0031990-04-15T00:00:001990-04-15T00:00:00Cell Line11.911180462595053e-0031990-04-15T00:00:001990-04-15T00:00:00Veronica Alvarez, M.D.VeronicaAlvarez

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterPathologyClinical Fellow in PathologyFellow or Post DocBeth Israel Deaconess Medical CenterBoston, MAResidencyhttp://www.ncbi.nlm.nih.gov/pubmed/41212933Improving Diagnostic Yield in Peritoneal Endometriosis: Value of Additional Level Sections and Sampling Protocols. Int J Gynecol Pathol. 2025 Oct 23.Alvarez V, Parent E, Hecht JL. Int J Gynecol Pathol2025 Oct 23http://www.ncbi.nlm.nih.gov/pubmed/38132479Clinical Significance of SOX10 Expression in Human Pathology. Curr Issues Mol Biol. 2023 Dec 15; 45(12):10131-10158.Bahmad HF, Thiravialingam A, Sriganeshan K, Gonzalez J, Alvarez V, Ocejo S, Abreu AR, Avellan R, Arzola AH, Hachem S, Poppiti R. Curr Issues Mol Biol2023 Dec 1545(12):10131-10158Paula Ketilly Nascimento Alves, Ph.D.PaulaAlves

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterSurgeryResearch Fellow in SurgeryFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41724331Gas entrapping materials for damage control. Adv Drug Deliv Rev. 2026 May; 232:115813.Alves PKN, Sutton IC, Byrne JD, Otterbein LE. Adv Drug Deliv Rev2026 May232:115813Gasotransmitters19.637443123016326e-0012026-02-20T00:00:002026-02-20T00:00:00Hydrogen Sulfide18.632384966520146e-0012026-02-20T00:00:002026-02-20T00:00:00Carbon Monoxide17.474694915218108e-0012026-02-20T00:00:002026-02-20T00:00:00Nitric Oxide15.150259190057880e-0012026-02-20T00:00:002026-02-20T00:00:00Drug Delivery Systems14.331861624879435e-0012026-02-20T00:00:002026-02-20T00:00:00Hydrogels11.546526439700703e-0012026-02-20T00:00:002026-02-20T00:00:00Animals12.544616787439947e-0022026-02-20T00:00:002026-02-20T00:00:00Humans11.069535980412547e-0022026-02-20T00:00:002026-02-20T00:00:00Rodrigo Wagner Alves De Souza, Ph.D.RodrigoAlves De Souza

Center for Life ScienceRoom 6033 Blackfan CircleBoston, MA 02115617/735-2851

1BIDMCBeth Israel Deaconess Medical CenterSurgeryAssistant Professor of SurgeryAssistant ProfessorAmerican Heart Association20192022University of Sao PauloSão Paulo, BrazilPostdoc03/2019PhysiologyUniversity of CampinasSão Paulo, BrazilPhD11/2014Cell BiologyBeth Israel Deaconess Medical Center, HMSBostonPostdoc fellow12/2018PhysiologyPIThe role of heme in exercise-induced protection against cardiotoxicityAHA2019-04-012022-03-31Rodrigo W. Alves de Souzahttp://www.ncbi.nlm.nih.gov/pubmed/39417235Metal-Free CO Prodrugs Activated by Molecular Oxygen Protect against Doxorubicin-Induced Cardiomyopathy in Mice. J Med Chem. 2024 Nov 14; 67(21):18981-18992.Yang X, Lu W, Alves de Souza RW, Mao Q, Baram D, Tripathi R, Wang G, Otterbein LE, Wang B. J Med Chem2024 Nov 1467(21):18981-18992http://www.ncbi.nlm.nih.gov/pubmed/38700010Beneficial Effects of Oral Carbon Monoxide on Doxorubicin-Induced Cardiotoxicity. J Am Heart Assoc. 2024 May 07; 13(9):e032067.Alves de Souza RW, Voltarelli V, Gallo D, Shankar S, Tift MS, Young M, Gomperts E, Gomperts A, Otterbein LE. J Am Heart Assoc2024 May 0713(9):e032067http://www.ncbi.nlm.nih.gov/pubmed/37237940Heme: The Lord of the Iron Ring. Antioxidants (Basel). 2023 May 10; 12(5).Voltarelli VA, Alves de Souza RW, Miyauchi K, Hauser CJ, Otterbein LE. Antioxidants (Basel)2023 May 1012(5)http://www.ncbi.nlm.nih.gov/pubmed/34764047Carbon monoxide and a change of heart. Redox Biol. 2021 12; 48:102183.Chu LM, Shaefi S, Byrne JD, Alves de Souza RW, Otterbein LE. Redox Biol2021 1248:102183http://www.ncbi.nlm.nih.gov/pubmed/34520397Trauma-induced heme release increases susceptibility to bacterial infection. JCI Insight. 2021 10 22; 6(20).Lee GR, Gallo D, Alves de Souza RW, Tiwari-Heckler S, Csizmadia E, Harbison JD, Shankar S, Banner-Goodspeed V, Yaffe MB, Longhi MS, Hauser CJ, Otterbein LE. JCI Insight2021 10 226(20)http://www.ncbi.nlm.nih.gov/pubmed/32427794Local and Systemic Inflammation and Oxidative Stress After a Single Bout of Maximal Walking in Patients With Symptomatic Peripheral Artery Disease. J Cardiovasc Nurs. 2021 Sep-Oct 01; 36(5):498-506.Andrade-Lima A, da Silva Junior N, Chehuen M, Miyasato R, Souza RWA, Leicht AS, Brum PC, de Oliveira EM, Wolosker N, Forjaz CLM. J Cardiovasc Nurs2021 Sep-Oct 0136(5):498-506http://www.ncbi.nlm.nih.gov/pubmed/34495225Physiological Responses to Maximal and Submaximal Walking in Patients with Symptomatic Peripheral Artery Disease. Arq Bras Cardiol. 2021 08; 117(2):309-316.Chehuen M, Andrade-Lima A, Silva Junior N, Miyasato R, Souza RWA, Leicht A, Brum PC, Oliveira EM, Wolosker N, Forjaz CLM. Arq Bras Cardiol2021 08117(2):309-316http://www.ncbi.nlm.nih.gov/pubmed/33882313Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity. Cell Rep. 2021 04 20; 35(3):109018.Alves de Souza RW, Gallo D, Lee GR, Katsuyama E, Schaufler A, Weber J, Csizmadia E, Tsokos GC, Koch LG, Britton SL, Wisløff U, Brum PC, Otterbein LE. Cell Rep2021 04 2035(3):109018http://www.ncbi.nlm.nih.gov/pubmed/33875324Walking Training Improves Systemic and Local Pathophysiological Processes in Intermittent Claudication. Eur J Vasc Endovasc Surg. 2021 06; 61(6):954-963.Andrade-Lima A, Silva Junior N, Chehuen M, Miyasato R, Souza RWA, Leicht AS, Brum PC, de Oliveira EM, Wolosker N, Forjaz CLM. Eur J Vasc Endovasc Surg2021 0661(6):954-963http://www.ncbi.nlm.nih.gov/pubmed/32792988Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia. Front Physiol. 2020; 11:886.Tift MS, Alves de Souza RW, Weber J, Heinrich EC, Villafuerte FC, Malhotra A, Otterbein LE, Simonson TS. Front Physiol202011:886http://www.ncbi.nlm.nih.gov/pubmed/30857457Intense resistance training induces pronounced metabolic stress and impairs hypertrophic response in hind-limb muscles of rats. Stress. 2019 05; 22(3):377-386.Guzzoni V, Briet L, Costa R, Souza RWA, Carani FR, Dal-Pai-Silva M, Silva KAS, Cunha TS, Marcondes FK. Stress2019 0522(3):377-386http://www.ncbi.nlm.nih.gov/pubmed/30538258Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep. 2018 12 11; 8(1):17772.Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC. Sci Rep2018 12 118(1):17772http://www.ncbi.nlm.nih.gov/pubmed/28765595Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia. Sci Rep. 2017 08 01; 7(1):6998.Moraes LN, Fernandez GJ, Vechetti-Júnior IJ, Freire PP, Souza RWA, Villacis RAR, Rogatto SR, Reis PP, Dal-Pai-Silva M, Carvalho RF. Sci Rep2017 08 017(1):6998http://www.ncbi.nlm.nih.gov/pubmed/28757440Nitric oxide synthase inhibition impairs muscle regrowth following immobilization. Nitric Oxide. 2017 Sep 30; 69:22-27.Aguiar AF, Vechetti-Júnior IJ, Souza RW, Piedade WP, Pacagnelli FL, Leopoldo AS, Casonatto J, Dal-Pai-Silva M. Nitric Oxide2017 Sep 3069:22-27http://www.ncbi.nlm.nih.gov/pubmed/27219629Training improves the oxidative phenotype of muscle during the transition from cardiac hypertrophy to heart failure without altering MyoD and myogenin. Exp Physiol. 2016 08 01; 101(8):1075-85.Pacagnelli FL, Aguiar AF, Campos DH, Castan EP, de Souza RW, de Almeida FL, Carani F, Carvalho RF, Cicogna AC, Silva MD. Exp Physiol2016 08 01101(8):1075-85http://www.ncbi.nlm.nih.gov/pubmed/26904163Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. Oxid Med Cell Longev. 2016; 2016:4374671.Bacurau AV, Cunha TF, Souza RW, Voltarelli VA, Gabriel-Costa D, Brum PC. Oxid Med Cell Longev20162016:4374671http://www.ncbi.nlm.nih.gov/pubmed/26408546Regulation of cardiac microRNAs induced by aerobic exercise training during heart failure. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1629-41.Souza RW, Fernandez GJ, Cunha JP, Piedade WP, Soares LC, Souza PA, de Campos DH, Okoshi K, Cicogna AC, Dal-Pai-Silva M, Carvalho RF. Am J Physiol Heart Circ Physiol2015 Nov 15309(10):H1629-41http://www.ncbi.nlm.nih.gov/pubmed/25991827Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1a Complex in Aged Rats. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):601-9.Vechetti-Junior IJ, Bertaglia RS, Fernandez GJ, de Paula TG, de Souza RW, Moraes LN, Mareco EA, de Freitas CE, Aguiar AF, Carvalho RF, Dal-Pai-Silva M. J Gerontol A Biol Sci Med Sci2016 May71(5):601-9http://www.ncbi.nlm.nih.gov/pubmed/25330387Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions. PLoS One. 2014; 9(10):e110020.Souza RW, Piedade WP, Soares LC, Souza PA, Aguiar AF, Vechetti-Júnior IJ, Campos DH, Fernandes AA, Okoshi K, Carvalho RF, Cicogna AC, Dal-Pai-Silva M. PLoS One20149(10):e110020http://www.ncbi.nlm.nih.gov/pubmed/24531430Resistance training with excessive training load and insufficient recovery alters skeletal muscle mass-related protein expression. J Strength Cond Res. 2014 Aug; 28(8):2338-45.Alves Souza RW, Aguiar AF, Vechetti-Júnior IJ, Piedade WP, Rocha Campos GE, Dal-Pai-Silva M. J Strength Cond Res2014 Aug28(8):2338-45http://www.ncbi.nlm.nih.gov/pubmed/23549689NFAT isoforms regulate muscle fiber type transition without altering CaN during aerobic training. Int J Sports Med. 2013 Oct; 34(10):861-7.Vechetti IJ, Aguiar AF, de Souza RW, Almeida FL, de Almeida Dias HB, de Aguiar Silva MA, Carani FR, Ferraresso RL, Carvalho RF, Dal-Pai-Silva M. Int J Sports Med2013 Oct34(10):861-7http://www.ncbi.nlm.nih.gov/pubmed/23059557Myogenin, MyoD and IGF-I regulate muscle mass but not fiber-type conversion during resistance training in rats. Int J Sports Med. 2013 Apr; 34(4):293-301.Aguiar AF, Vechetti-Júnior IJ, Alves de Souza RW, Castan EP, Milanezi-Aguiar RC, Padovani CR, Carvalho RF, Silva MD. Int J Sports Med2013 Apr34(4):293-301http://www.ncbi.nlm.nih.gov/pubmed/21714108High-intensity resistance training with insufficient recovery time between bouts induce atrophy and alterations in myosin heavy chain content in rat skeletal muscle. Anat Rec (Hoboken). 2011 Aug; 294(8):1393-400.De Souza RW, Aguiar AF, Carani FR, Campos GE, Padovani CR, Silva MD. Anat Rec (Hoboken)2011 Aug294(8):1393-400http://www.ncbi.nlm.nih.gov/pubmed/20349269Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy. J Mol Histol. 2010 Feb; 41(1):81-7.Carvalho RF, Castan EP, Coelho CA, Lopes FS, Almeida FL, Michelin A, de Souza RW, Araújo JP, Cicogna AC, Dal Pai-Silva M. J Mol Histol2010 Feb41(1):81-7http://www.ncbi.nlm.nih.gov/pubmed/20563927Nandrolone stimulates MyoD expression during muscle regeneration in the condition of myonecrosis induced by Bothrops jararacussu venom poisoning. J Toxicol Environ Health A. 2010; 73(13-14):934-43.Wagner Alves de Souza R, Gonçalves W, Garrido Cavalcante WL, Pai-Silva MD, Gallacci M. J Toxicol Environ Health A201073(13-14):934-43Physical Conditioning, Animal71.271647071586270e+0002012-10-11T00:00:002021-04-20T00:00:00Carbon Monoxide39.688179398348321e-0012021-11-08T00:00:002024-10-17T00:00:00Muscular Atrophy69.600599759436272e-0012010-03-28T00:00:002021-04-20T00:00:00Muscle, Skeletal129.365509962283343e-0012011-06-28T00:00:002021-09-01T00:00:00Walking39.198720585923375e-0012021-04-16T00:00:002021-09-01T00:00:00Heme Oxygenase-137.929973709258276e-0012021-04-20T00:00:002024-10-17T00:00:00Resistance Training47.670519378248533e-0012011-06-28T00:00:002019-03-12T00:00:00Heme27.462091956849597e-0012021-04-20T00:00:002021-10-22T00:00:00Muscle Fibers, Skeletal47.305727657666126e-0012010-03-28T00:00:002021-04-20T00:00:00Cardiotoxicity17.056427333811721e-0012024-05-03T00:00:002024-05-03T00:00:00Doxorubicin26.615529154831534e-0012024-05-03T00:00:002024-10-17T00:00:00Antibiotics, Antineoplastic16.423307735940576e-0012024-05-03T00:00:002024-05-03T00:00:00MyoD Protein56.334050676886561e-0012010-01-01T00:00:002021-04-20T00:00:00Intermittent Claudication25.996504905097273e-0012021-04-16T00:00:002021-08-01T00:00:00Nitric Oxide Synthase Type I15.085010148206152e-0012017-07-28T00:00:002017-07-28T00:00:00Membrane Proteins24.666662253469923e-0012021-04-20T00:00:002024-05-03T00:00:00Rats, Wistar124.642219978309542e-0012010-03-28T00:00:002019-03-12T00:00:00Oxidative Stress34.579546233095245e-0012018-12-11T00:00:002021-09-01T00:00:00Physical Exertion24.446635344831703e-0012014-08-01T00:00:002014-10-17T00:00:00Nitric Oxide Synthase Type III14.331007416607128e-0012017-07-28T00:00:002017-07-28T00:00:00Peripheral Arterial Disease23.663832818287596e-0012021-08-01T00:00:002021-09-01T00:00:00Regeneration23.638311106611527e-0012010-01-01T00:00:002017-07-28T00:00:00Myogenin33.306322360881766e-0012012-10-11T00:00:002016-07-17T00:00:00Muscle Proteins52.825733773630673e-0012010-03-28T00:00:002021-04-20T00:00:00Exercise22.794633036087170e-0012016-01-19T00:00:002021-04-16T00:00:00Hypertrophy22.793152532831147e-0012012-10-11T00:00:002019-03-12T00:00:00Tripartite Motif Proteins42.324151510528013e-0012010-03-28T00:00:002021-04-20T00:00:00Cachexia12.283875641946074e-0012017-08-01T00:00:002017-08-01T00:00:00SKP Cullin F-Box Protein Ligases42.279712489426773e-0012010-03-28T00:00:002015-05-19T00:00:00Atrial Remodeling12.254029870365533e-0012015-09-25T00:00:002015-09-25T00:00:00Exercise Test32.221888911150200e-0012021-04-16T00:00:002021-09-01T00:00:00Carboxyhemoglobin12.121576354741739e-0012024-05-03T00:00:002024-05-03T00:00:00Inflammation22.077284193856194e-0012021-04-16T00:00:002021-09-01T00:00:00Muscular Diseases22.018895706417366e-0012010-01-01T00:00:002016-01-19T00:00:00Heart Failure61.935520651307414e-0012010-03-28T00:00:002017-08-01T00:00:00Prodrugs11.870460845602519e-0012024-10-17T00:00:002024-10-17T00:00:00PAX7 Transcription Factor11.730592544779582e-0012021-04-20T00:00:002021-04-20T00:00:00Ferrochelatase11.723465325836327e-0012021-04-20T00:00:002021-04-20T00:00:00Stress, Physiological11.711607308110724e-0012019-03-12T00:00:002019-03-12T00:00:00Low Density Lipoprotein Receptor-Related Protein-111.687561039998873e-0012021-04-20T00:00:002021-04-20T00:00:00Adaptation, Physiological31.669271728137590e-0012012-10-11T00:00:002021-04-16T00:00:005-Aminolevulinate Synthetase11.669115955403243e-0012021-04-20T00:00:002021-04-20T00:00:00Sedentary Behavior11.607706472242200e-0012015-09-25T00:00:002015-09-25T00:00:00Nandrolone11.600459435511901e-0012010-01-01T00:00:002010-01-01T00:00:00MicroRNAs21.599753846761463e-0012015-09-25T00:00:002017-08-01T00:00:00Crotalid Venoms11.593383421374288e-0012010-01-01T00:00:002010-01-01T00:00:00Snake Bites11.532491620722699e-0012010-01-01T00:00:002010-01-01T00:00:00Ubiquitin-Protein Ligases41.524991164166324e-0012010-03-28T00:00:002021-04-20T00:00:00Rats111.471540457754132e-0012010-03-28T00:00:002019-03-12T00:00:00Vascular Cell Adhesion Molecule-111.441953845686487e-0012021-04-16T00:00:002021-04-16T00:00:00Superoxide Dismutase11.426489144453511e-0012021-04-16T00:00:002021-04-16T00:00:00Gene Expression Regulation31.408441235610993e-0012010-03-28T00:00:002021-04-20T00:00:00Animals201.355115860868031e-0012010-01-01T00:00:002024-10-17T00:00:00Ventricular Remodeling11.345454782131346e-0012015-09-25T00:00:002015-09-25T00:00:00Anabolic Agents11.328000180035210e-0012010-01-01T00:00:002010-01-01T00:00:00Hindlimb Suspension11.304785632326427e-0012017-07-28T00:00:002017-07-28T00:00:00Nitrites11.289432017661487e-0012017-07-28T00:00:002017-07-28T00:00:00Rest21.284284074726396e-0012014-08-01T00:00:002019-03-12T00:00:00NG-Nitroarginine Methyl Ester11.274620729184252e-0012017-07-28T00:00:002017-07-28T00:00:00Isoenzymes11.245554481052898e-0012021-04-20T00:00:002021-04-20T00:00:00Myocardium21.210126963016277e-0012017-08-01T00:00:002018-12-11T00:00:00Muscle Fibers, Slow-Twitch21.203667664122177e-0012011-06-28T00:00:002013-04-02T00:00:00Muscle Fibers, Fast-Twitch21.194051713087818e-0012011-06-28T00:00:002013-04-02T00:00:00Administration, Oral11.193637702013456e-0012024-05-03T00:00:002024-05-03T00:00:00Nitrates11.185053099028279e-0012017-07-28T00:00:002017-07-28T00:00:00Insulin-Like Growth Factor I21.181375794359822e-0012012-10-11T00:00:002014-08-01T00:00:00Heart Disease Risk Factors11.169244233874560e-0012021-04-16T00:00:002021-04-16T00:00:00Mice, Inbred C57BL31.159459570654639e-0012021-04-20T00:00:002024-10-17T00:00:00Muscles11.117011272731477e-0012010-01-01T00:00:002010-01-01T00:00:00Sarcomeres11.077744926925938e-0012017-07-28T00:00:002017-07-28T00:00:00Cysteine11.027983284789820e-0012018-12-11T00:00:002018-12-11T00:00:00Cardiomegaly11.025470762028258e-0012016-07-17T00:00:002016-07-17T00:00:00RNA, Messenger21.013837062674092e-0012012-10-11T00:00:002017-08-01T00:00:00Bacterial Infections19.959482214633665e-0022021-10-22T00:00:002021-10-22T00:00:00Myosin Heavy Chains29.824887505859918e-0022011-06-28T00:00:002013-04-02T00:00:00Oxygen19.714239497719480e-0022024-10-17T00:00:002024-10-17T00:00:00Nitric Oxide19.200420237999908e-0022021-04-16T00:00:002021-04-16T00:00:00Calcineurin19.073225797774975e-0022013-04-02T00:00:002013-04-02T00:00:00Swimming18.945287065142361e-0022013-04-02T00:00:002013-04-02T00:00:00Cardiomyopathies18.934371102647264e-0022024-10-17T00:00:002024-10-17T00:00:00Gene Expression Profiling18.571513596008895e-0022017-08-01T00:00:002017-08-01T00:00:00Disease Models, Animal38.538978874953943e-0022015-09-25T00:00:002024-05-03T00:00:00Imidazoles18.533926441305313e-0022017-07-28T00:00:002017-07-28T00:00:00Heart Diseases18.493537871944654e-0022024-05-03T00:00:002024-05-03T00:00:00NFATC Transcription Factors18.462249144528886e-0022013-04-02T00:00:002013-04-02T00:00:00Ventricular Function, Left18.365120639297423e-0022024-05-03T00:00:002024-05-03T00:00:00Mice57.760154073762356e-0022010-01-01T00:00:002024-10-17T00:00:00Real-Time Polymerase Chain Reaction37.615442022240808e-0022012-10-11T00:00:002015-09-25T00:00:00Hemorrhage17.526221302533720e-0022021-10-22T00:00:002021-10-22T00:00:00Atrophy17.501885839014487e-0022014-08-01T00:00:002014-08-01T00:00:00C-Reactive Protein17.475828638423071e-0022021-04-16T00:00:002021-04-16T00:00:00Random Allocation27.300481178153490e-0022013-04-02T00:00:002019-03-12T00:00:00Male177.126397437585826e-0022010-01-01T00:00:002024-10-17T00:00:00TOR Serine-Threonine Kinases17.059737798682290e-0022017-07-28T00:00:002017-07-28T00:00:00Wounds and Injuries17.039993451384433e-0022021-10-22T00:00:002021-10-22T00:00:00Energy Metabolism16.644973534043755e-0022018-12-11T00:00:002018-12-11T00:00:00Recovery of Function26.497717680171090e-0022011-06-28T00:00:002015-05-19T00:00:00Mitochondria16.495458662022785e-0022021-04-20T00:00:002021-04-20T00:00:00Body Weight16.211772750588822e-0022017-07-28T00:00:002017-07-28T00:00:00Histocytochemistry16.124544034105697e-0022017-08-01T00:00:002017-08-01T00:00:00Outcome Assessment, Health Care15.902708961667257e-0022021-04-16T00:00:002021-04-16T00:00:00Mice, Knockout15.790544765248858e-0022021-04-20T00:00:002021-04-20T00:00:00Biometry15.178682156520322e-0022017-08-01T00:00:002017-08-01T00:00:00RAW 264.7 Cells15.170990213198121e-0022024-10-17T00:00:002024-10-17T00:00:00Forkhead Box Protein O125.141269570203217e-0022014-10-17T00:00:002015-05-19T00:00:00Physical Endurance25.007347678844967e-0022013-04-02T00:00:002018-12-11T00:00:00Signal Transduction24.546920380567097e-0022015-09-25T00:00:002021-04-20T00:00:00Morphogenesis14.458019118731365e-0022015-09-25T00:00:002015-09-25T00:00:00Oxidation-Reduction24.329205968594035e-0022016-07-17T00:00:002018-12-11T00:00:00Bothrops14.034671559160902e-0022010-01-01T00:00:002010-01-01T00:00:00Malate Dehydrogenase13.672398240173953e-0022018-12-11T00:00:002018-12-11T00:00:00Transcription Factors23.533391909302680e-0022013-04-02T00:00:002015-05-19T00:00:00Cell Respiration13.476189115409007e-0022018-12-11T00:00:002018-12-11T00:00:00Humans73.350197115377687e-0022016-01-19T00:00:002024-05-03T00:00:00Forkhead Transcription Factors23.303812389959201e-0022014-10-17T00:00:002015-05-19T00:00:00Mice, Inbred Strains13.278070224098178e-0022010-01-01T00:00:002010-01-01T00:00:00Necrosis12.880072679815442e-0022010-01-01T00:00:002010-01-01T00:00:00Myocytes, Cardiac12.839096676681880e-0022024-10-17T00:00:002024-10-17T00:00:00Biomarkers22.837155485747468e-0022013-04-02T00:00:002014-08-01T00:00:00Reverse Transcriptase Polymerase Chain Reaction22.732789955636592e-0022010-03-28T00:00:002013-04-02T00:00:00Immobilization12.650734976255557e-0022015-05-19T00:00:002015-05-19T00:00:00Running12.562850858280916e-0022018-12-11T00:00:002018-12-11T00:00:00Exercise Tolerance12.467790991172784e-0022018-12-11T00:00:002018-12-11T00:00:00Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha12.439851864014185e-0022015-05-19T00:00:002015-05-19T00:00:00Aortic Valve Stenosis12.389419044916885e-0022015-09-25T00:00:002015-09-25T00:00:00Nerve Tissue Proteins22.293463221144762e-0022014-10-17T00:00:002015-05-19T00:00:00Protein Processing, Post-Translational12.130723457932539e-0022018-12-11T00:00:002018-12-11T00:00:00Cytokines12.041108739290482e-0022015-09-25T00:00:002015-09-25T00:00:00Monocrotaline12.037487507649299e-0022010-03-28T00:00:002010-03-28T00:00:00Models, Biological11.952639452063031e-0022016-01-19T00:00:002016-01-19T00:00:00Apoptosis11.936023698688636e-0022015-09-25T00:00:002015-09-25T00:00:00Heart Rate11.903953210409267e-0022021-08-01T00:00:002021-08-01T00:00:00Middle Aged21.879110675242987e-0022021-04-16T00:00:002021-10-22T00:00:00Electrophoresis, Polyacrylamide Gel11.837095691212562e-0022011-06-28T00:00:002011-06-28T00:00:00Protein Isoforms11.736543293583051e-0022013-04-02T00:00:002013-04-02T00:00:00Female21.642037310969347e-0022021-10-22T00:00:002024-05-03T00:00:00Staining and Labeling11.606419593882761e-0022011-06-28T00:00:002011-06-28T00:00:00Adenosine Triphosphatases11.598613093738897e-0022011-06-28T00:00:002011-06-28T00:00:00NF-kappa B11.502656078270608e-0022014-10-17T00:00:002014-10-17T00:00:00Blood Pressure11.419067696088868e-0022021-08-01T00:00:002021-08-01T00:00:00Organ Specificity11.410614676744234e-0022010-03-28T00:00:002010-03-28T00:00:00Case-Control Studies11.284490346400373e-0022021-10-22T00:00:002021-10-22T00:00:00Tumor Necrosis Factor-alpha11.247023134762096e-0022014-10-17T00:00:002014-10-17T00:00:00Weight Gain11.064031488376973e-0022011-06-28T00:00:002011-06-28T00:00:00Age Factors18.860416013474138e-0032015-05-19T00:00:002015-05-19T00:00:00Young Adult16.670559449193955e-0032021-10-22T00:00:002021-10-22T00:00:00Adolescent16.012426590989981e-0032021-10-22T00:00:002021-10-22T00:00:00Time Factors14.761313428114402e-0032011-06-28T00:00:002011-06-28T00:00:00Aged14.320600326805198e-0032021-10-22T00:00:002021-10-22T00:00:00Adult13.867477344446337e-0032021-10-22T00:00:002021-10-22T00:00:00Francinny Alves Kelly, M.D.FrancinnyAlves Kelly

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215

1BIDMCBeth Israel Deaconess Medical CenterMedicineCardiologyResearch Fellow in MedicineFellow or Post DocUniversidade Sao Caetano do Sul Sao Paulo - BrazilMD06/2022Medicinehttp://www.ncbi.nlm.nih.gov/pubmed/41364240Bleeding risk associated with the co-use of direct oral anticoagulants and non-dihydropyridine calcium channel blockers: a meta-analysis. Herz. 2025 Dec 09.Alves Kelly F, Andrade de Faria E, Rocha Dantas C, Ritter Lima AAF, Dups Talah BA, de Oliveira Macena Lôbo A, Laurinavicius AG, Marciano Consolim-Colombo F. Herz2025 Dec 09http://www.ncbi.nlm.nih.gov/pubmed/40968352Stroke risk in cancer survivors: A meta-analysis and meta regression. Neurol Sci. 2025 Nov; 46(11):5943-5953.de Moraes FCA, Matheus GTFU, Souza MEC, de Almeida AM, Gonçalves ODDRR, Silva ALM, Padilha LB, Kelly FA, Burbano RMR. Neurol Sci2025 Nov46(11):5943-5953http://www.ncbi.nlm.nih.gov/pubmed/40752805Effects of oral semaglutide on cardiovascular outcomes: A systematic review and meta-analysis. Int J Cardiol. 2025 Dec 01; 440:133683.Rebelo TG, de Araujo Paysano MLB, Matheus GTFU, Ribeiro DM, Said TB, Kelly FA. Int J Cardiol2025 Dec 01440:133683http://www.ncbi.nlm.nih.gov/pubmed/40629108Comparison of mortality and cardiovascular morbidity following treatment for hyperthyroidism: A systematic review and bayesian network meta-analysis. Endocrine. 2025 Oct; 90(1):39-48.de Oliveira Macena Lôbo A, Sobreira LER, Ribeiro DM, Aguiar IJM, Kelly FA. Endocrine2025 Oct90(1):39-48http://www.ncbi.nlm.nih.gov/pubmed/39470778Erratum to: Efficacy of sacubitril-valsartan vs. angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in preventing atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis. Herz. 2025 Apr; 50(2):148.Baía Bezerra F, Rodrigues Sobreira LE, Tsuchiya Sano VK, de Oliveira Macena Lôbo A, Cavalcanti Orestes Cardoso JH, Alves Kelly F, Aquino de Moraes FC, Consolim-Colombo FM. Herz2025 Apr50(2):148http://www.ncbi.nlm.nih.gov/pubmed/39841433Bright Light Therapy for Nonseasonal Depressive Disorders-Reply. JAMA Psychiatry. 2025 Mar 01; 82(3):324-325.Menegaz de Almeida A, Aquino Moraes FC, Kelly FA. JAMA Psychiatry2025 Mar 0182(3):324-325http://www.ncbi.nlm.nih.gov/pubmed/39822593Statin use and dementia risk: A systematic review and updated meta-analysis. Alzheimers Dement (N Y). 2025; 11(1):e70039.Westphal Filho FL, Moss Lopes PR, Menegaz de Almeida A, Sano VKT, Tamashiro FM, Gonçalves OR, de Moraes FCA, Kreuz M, Kelly FA, Silveira Feitoza PV. Alzheimers Dement (N Y)202511(1):e70039http://www.ncbi.nlm.nih.gov/pubmed/39746208Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis. Obstet Gynecol. 2025 Mar 01; 145(3):253-261.Menegaz de Almeida A, Oliveira P, Lopes L, Leite M, Morbach V, Alves Kelly F, Barros Í, Aquino de Moraes FC, Prevedello A. Obstet Gynecol2025 Mar 01145(3):253-261http://www.ncbi.nlm.nih.gov/pubmed/39356500Bright Light Therapy for Nonseasonal Depressive Disorders: A Systematic Review and Meta-Analysis. JAMA Psychiatry. 2025 Jan 01; 82(1):38-46.Menegaz de Almeida A, Aquino de Moraes FC, Cavalcanti Souza ME, Cavalcanti Orestes Cardoso JH, Tamashiro F, Miranda C, Fernandes L, Kreuz M, Alves Kelly F. JAMA Psychiatry2025 Jan 0182(1):38-46http://www.ncbi.nlm.nih.gov/pubmed/39691061The effect of telehealth on clinical outcomes in patients with hypertension and diabetes: A meta-analysis of 106,261 patients. J Telemed Telecare. 2025 Dec; 31(10):1382-1400.Kelly FA, Moraes FCA, Lôbo AOM, Sano VKT, Souza MEC, Almeida AM, Kreuz M, Laurinavicius AG, Consolim-Colombo FM. J Telemed Telecare2025 Dec31(10):1382-1400http://www.ncbi.nlm.nih.gov/pubmed/39500846A systematic review and meta-analysis of cardiovascular disease risk with degarelix and GnRH agonists in prostate cancer. Clin Transl Oncol. 2025 Jun; 27(6):2679-2688.de Moraes FCA, Sano VKT, Dantas CR, Hoffmeister N, Kelly FA, Burbano RMR. Clin Transl Oncol2025 Jun27(6):2679-2688http://www.ncbi.nlm.nih.gov/pubmed/39472408Efficacy and Safety of Ultrasound Renal Denervation on Office Blood Pressure of Patients with Resistant Arterial Hypertension: A Systematic Review and Meta-analysis. High Blood Press Cardiovasc Prev. 2024 Nov; 31(6):657-667.Maia JG, Kelly FA, Gonçalves OR, de Moraes FCA, de Sousa MG, Consolim-Colombo FM. High Blood Press Cardiovasc Prev2024 Nov31(6):657-667http://www.ncbi.nlm.nih.gov/pubmed/39412534Association between ovarian tumors and exposure to assisted reproductive technologies and ovarian stimulation: a systematic review and meta-analysis. Arch Gynecol Obstet. 2024 Dec; 310(6):2753-2765.Lôbo AOM, Morbach V, Kelly FA, de Moraes FCA. Arch Gynecol Obstet2024 Dec310(6):2753-2765http://www.ncbi.nlm.nih.gov/pubmed/39395908Systematic Review and Meta-Analysis of Second-Generation Sham-Controlled Randomized Trials of Renal Denervation Therapy for Patients with Hypertension. High Blood Press Cardiovasc Prev. 2024 Nov; 31(6):669-676.Dantas CR, De Oliveira Macena Lôbo A, De Almeida AM, De Moraes FCA, Sano VKT, Kelly FA. High Blood Press Cardiovasc Prev2024 Nov31(6):669-676http://www.ncbi.nlm.nih.gov/pubmed/39331347Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Endocrine. 2025 Feb; 87(2):389-399.Kelly FA, de Oliveira Macena Lôbo A, Cardoso JHCO, de Moraes FCA. Endocrine2025 Feb87(2):389-399http://www.ncbi.nlm.nih.gov/pubmed/39313691Efficacy of sacubitril-valsartan vs. angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in preventing atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis. Herz. 2025 Apr; 50(2):135-141.Baía Bezerra F, Rodrigues Sobreira LE, Tsuchiya Sano VK, de Oliveira Macena Lôbo A, Cavalcanti Orestes Cardoso JH, Alves Kelly F, Aquino de Moraes FC, Consolim-Colombo FM. Herz2025 Apr50(2):135-141http://www.ncbi.nlm.nih.gov/pubmed/39254858Assessing the efficacy of renal denervation in patients with resistant arterial hypertension : Systematic review and meta-analysis. Herz. 2025 Feb; 50(1):34-41.Gonçalves OR, Kelly FA, Maia JG, de Oliveira Macena Lôbo A, Tsuchiya Sano VK, Cavalcanti Souza ME, de Moraes FCA, Farid N, Bispo da Silva Júnior A, da Silva AA. Herz2025 Feb50(1):34-41http://www.ncbi.nlm.nih.gov/pubmed/39550238Safety and efficacy of moderate-intensity statin plus ezetimibe versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease: A meta-analysis. J Clin Lipidol. 2024; 18(6):e893-e904.Kelly FA, de Moraes FCA, Lôbo AOM, Siebel VM, Leite M, de Almeida AM, Consolim-Colombo FM. J Clin Lipidol202418(6):e893-e904http://www.ncbi.nlm.nih.gov/pubmed/38987454Liraglutide for the Treatment of Weight Regain After Bariatric Surgery: A Systematic Review and Meta-analysis. Obes Surg. 2024 Aug; 34(8):2844-2853.de Moraes FCA, Morbach V, Sano VKT, Fernandes LR, Kreuz M, Kelly FA. Obes Surg2024 Aug34(8):2844-2853http://www.ncbi.nlm.nih.gov/pubmed/38913175Impact of adjuvant chemotherapy on survival after pathological complete response in rectal cancer: a meta-analysis of 31,558 patients. Int J Colorectal Dis. 2024 Jun 24; 39(1):96.de Moraes FCA, Kelly FA, Souza MEC, Burbano RMR. Int J Colorectal Dis2024 Jun 2439(1):96http://www.ncbi.nlm.nih.gov/pubmed/38890242Efficacy and Safety of Radiofrequency-Based Renal Denervation on Resistant Hypertensive Patients: A Systematic Review and Meta-analysis. High Blood Press Cardiovasc Prev. 2024 Jul; 31(4):329-340.Sobreira LER, Bezerra FB, Sano VKT, de Oliveira Macena Lôbo A, Cardoso JHCO, Kelly FA, de Moraes FCA, Consolim-Colombo FM. High Blood Press Cardiovasc Prev2024 Jul31(4):329-340Sympathectomy41.667138538023622e+0002024-06-19T00:00:002024-10-29T00:00:00Phototherapy16.963322017788315e-0012025-01-01T00:00:002025-01-01T00:00:00Drug Resistance36.420859882888643e-0012024-06-19T00:00:002024-10-29T00:00:00Kidney45.837937023124024e-0012024-06-19T00:00:002024-10-29T00:00:00Renal Artery35.766627127924031e-0012024-06-19T00:00:002024-10-29T00:00:00Hypertension54.703519798281979e-0012024-06-19T00:00:002024-12-18T00:00:00Inositol14.078054115729631e-0012024-09-27T00:00:002024-09-27T00:00:00Liraglutide13.890851133007270e-0012024-07-10T00:00:002024-07-10T00:00:00Glucagon-Like Peptides13.788641313179202e-0012025-07-31T00:00:002025-07-31T00:00:00Ezetimibe13.771820460382196e-0012024-08-14T00:00:002024-08-14T00:00:00Arterial Pressure13.741718276239468e-0012024-10-29T00:00:002024-10-29T00:00:00Depressive Disorder13.727804200164052e-0012025-01-01T00:00:002025-01-01T00:00:00Ovulation Induction13.662301571105766e-0012024-10-16T00:00:002024-10-16T00:00:00Randomized Controlled Trials as Topic83.227147967607181e-0012024-09-10T00:00:002025-07-31T00:00:00Reproductive Techniques, Assisted13.111939073011085e-0012024-10-16T00:00:002024-10-16T00:00:00Polycystic Ovary Syndrome13.004553812292785e-0012024-09-27T00:00:002024-09-27T00:00:00Oligopeptides12.976995200201351e-0012024-11-05T00:00:002024-11-05T00:00:00Gonadotropin-Releasing Hormone12.938185695062069e-0012024-11-05T00:00:002024-11-05T00:00:00Anticholesteremic Agents12.616724446937364e-0012024-08-14T00:00:002024-08-14T00:00:00Catheter Ablation22.590016988324367e-0012024-06-19T00:00:002024-09-23T00:00:00Metformin12.513472179248709e-0012024-09-27T00:00:002024-09-27T00:00:00Rectal Neoplasms12.270610237675844e-0012024-06-24T00:00:002024-06-24T00:00:00Antithyroid Agents12.268117785698158e-0012025-07-08T00:00:002025-07-08T00:00:00Hypoglycemic Agents22.130619671775803e-0012024-09-27T00:00:002025-07-31T00:00:00Weight Gain12.101039828305207e-0012024-07-10T00:00:002024-07-10T00:00:00Bariatric Surgery12.061655100869515e-0012024-07-10T00:00:002024-07-10T00:00:00Cancer Survivors12.005321959789173e-0012025-09-19T00:00:002025-09-19T00:00:00Obesity, Morbid11.976270604912800e-0012024-07-10T00:00:002024-07-10T00:00:00Hyperthyroidism11.953648426146463e-0012025-07-08T00:00:002025-07-08T00:00:00Blood Pressure31.942935572656438e-0012024-06-19T00:00:002024-12-18T00:00:00Pyrrolidines11.891790414413144e-0012025-01-02T00:00:002025-01-02T00:00:00Weight Loss11.882148608582545e-0012024-07-10T00:00:002024-07-10T00:00:00Cardiovascular Diseases31.839783568199033e-0012024-11-05T00:00:002025-07-31T00:00:00Hot Flashes11.799286210379132e-0012025-01-02T00:00:002025-01-02T00:00:00Iodine Radioisotopes11.781727422777415e-0012025-07-08T00:00:002025-07-08T00:00:00Antihypertensive Agents31.584244330701494e-0012024-06-19T00:00:002024-10-29T00:00:00Hydroxymethylglutaryl-CoA Reductase Inhibitors11.527911288221808e-0012024-08-14T00:00:002024-08-14T00:00:00Thyroidectomy11.504820205419315e-0012025-07-08T00:00:002025-07-08T00:00:00Diabetes Mellitus, Type 231.474784198273243e-0012024-07-10T00:00:002025-07-31T00:00:00Aminobutyrates11.421031444292211e-0012024-09-23T00:00:002024-09-23T00:00:00Atherosclerosis11.420199341762046e-0012024-08-14T00:00:002024-08-14T00:00:00Tetrazoles11.418460490162915e-0012024-09-23T00:00:002024-09-23T00:00:00Treatment Outcome91.405422316136529e-0012024-06-19T00:00:002025-07-31T00:00:00Angiotensin-Converting Enzyme Inhibitors11.347062683029086e-0012024-09-23T00:00:002024-09-23T00:00:00Angiotensin Receptor Antagonists11.342227820878137e-0012024-09-23T00:00:002024-09-23T00:00:00Ovarian Neoplasms11.316546160427989e-0012024-10-16T00:00:002024-10-16T00:00:00Menopause11.230991668374693e-0012025-01-02T00:00:002025-01-02T00:00:00Semaglutide11.110056478971527e-0012025-07-31T00:00:002025-07-31T00:00:00Drug Therapy, Combination21.075319577039317e-0012024-08-14T00:00:002024-09-27T00:00:00Stroke19.923762759444699e-0022025-09-19T00:00:002025-09-19T00:00:00Glucagon-Like Peptide 119.403433007766017e-0022025-07-31T00:00:002025-07-31T00:00:00Ultrasonic Therapy19.339702544623839e-0022024-10-29T00:00:002024-10-29T00:00:00Prostatic Neoplasms18.981266570559179e-0022024-11-05T00:00:002024-11-05T00:00:00Office Visits18.147634147830152e-0022024-10-29T00:00:002024-10-29T00:00:00Humans177.847144709040550e-0022024-06-19T00:00:002025-09-19T00:00:00Time Factors37.134270912043708e-0022024-06-19T00:00:002024-10-29T00:00:00Infertility, Female17.000385398817688e-0022024-10-16T00:00:002024-10-16T00:00:00Middle Aged86.608381009972361e-0022024-06-19T00:00:002025-01-02T00:00:00Administration, Oral16.505191513873121e-0022025-07-31T00:00:002025-07-31T00:00:00Telemedicine16.406803580979496e-0022024-12-18T00:00:002024-12-18T00:00:00Neoplasms16.007580045132450e-0022025-09-19T00:00:002025-09-19T00:00:00Chemotherapy, Adjuvant15.874614668276358e-0022024-06-24T00:00:002024-06-24T00:00:00Atrial Fibrillation15.837872541066976e-0022024-09-23T00:00:002024-09-23T00:00:00Female95.571977888367705e-0022024-06-19T00:00:002025-01-02T00:00:00Male85.508257982110574e-0022024-06-19T00:00:002024-11-05T00:00:00Cholesterol, LDL15.471081830103245e-0022024-08-14T00:00:002024-08-14T00:00:00Disease-Free Survival15.219951190994520e-0022024-06-24T00:00:002024-06-24T00:00:00Vasomotor System15.211286357779136e-0022025-01-02T00:00:002025-01-02T00:00:00Risk Factors34.941794738683219e-0022024-06-19T00:00:002025-09-19T00:00:00Neoadjuvant Therapy14.724714490540171e-0022024-06-24T00:00:002024-06-24T00:00:00Survival Analysis14.518832101994789e-0022024-06-24T00:00:002024-06-24T00:00:00Valsartan13.760310202672960e-0022024-09-23T00:00:002024-09-23T00:00:00Biphenyl Compounds13.738583371741545e-0022024-09-23T00:00:002024-09-23T00:00:00Aged43.679957067897954e-0022024-06-19T00:00:002024-10-12T00:00:00Secondary Prevention13.522856806198373e-0022024-09-23T00:00:002024-09-23T00:00:00Drug Combinations13.472961939035284e-0022024-09-23T00:00:002024-09-23T00:00:00Bayes Theorem13.204485675510325e-0022025-07-08T00:00:002025-07-08T00:00:00Case-Control Studies13.159336888038757e-0022024-10-16T00:00:002024-10-16T00:00:00Body Mass Index13.104916063645554e-0022024-07-10T00:00:002024-07-10T00:00:00Glycated Hemoglobin12.826401015343377e-0022024-12-18T00:00:002024-12-18T00:00:00Evidence-Based Medicine12.387748594619766e-0022024-09-23T00:00:002024-09-23T00:00:00Blood Glucose11.984704640363155e-0022024-12-18T00:00:002024-12-18T00:00:00Adult21.863723274250807e-0022024-06-19T00:00:002024-07-10T00:00:00Prevalence11.619322937935426e-0022024-09-23T00:00:002024-09-23T00:00:00Tooba Alwani, M.D.ToobaAlwani

Beth Israel Deaconess Medical CenterDivision: Adm-House Staff330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterMedicineAdm-House StaffClinical Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/40451473Evaluating the J Wave as a Marker of Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. J Am Soc Echocardiogr. 2025 Sep; 38(9):862-865.Alwani T, Akerman AP, Al-Roub N, Angell-James C, Cassidy MA, Thompson R, Bosque L, Rainer K, Hawkes W, Piotrowska H, Leeson P, Woodward G, Pellikka PA, Upton R, Strom JB. J Am Soc Echocardiogr2025 Sep38(9):862-865http://www.ncbi.nlm.nih.gov/pubmed/34889486Social determinants of health and treatment decisions in head and neck cancer. Head Neck. 2022 02; 44(2):372-381.Shehan JN, Alwani T, LeClair J, Mahoney TF, Agarwal P, Chaudhry ST, Wang JJ, Noordzij JP, Tracy LF, Edwards HA, Grillone G, Salama AR, Jalisi SM, Devaiah AK. Head Neck2022 0244(2):372-381http://www.ncbi.nlm.nih.gov/pubmed/34762300Geographic Barriers Affect Follow-Up Care in Head and Neck Cancer. Laryngoscope. 2022 05; 132(5):1022-1028.Alwani T, Shehan JN, LeClair J, Mahoney TF, Agarwal P, Chaudhry ST, Wang JJ, Noordzij JP, Tracy LF, Edwards HA, Grillone G, Salama AR, Jalisi SM, Devaiah AK. Laryngoscope2022 05132(5):1022-1028http://www.ncbi.nlm.nih.gov/pubmed/32978258Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy. J Biol Chem. 2020 12 04; 295(49):16691-16699.Amraei R, Alwani T, Ho RX, Aryan Z, Wang S, Rahimi N. J Biol Chem2020 12 04295(49):16691-16699Aftercare14.674512421027722e-0012021-11-11T00:00:002021-11-11T00:00:00Head and Neck Neoplasms23.143218131031934e-0012021-11-11T00:00:002021-12-10T00:00:00Social Determinants of Health21.884592822891932e-0012021-11-11T00:00:002021-12-10T00:00:00CD28 Antigens11.352976315943816e-0012020-09-25T00:00:002020-09-25T00:00:00AMP-Activated Protein Kinases11.276500032137286e-0012020-09-25T00:00:002020-09-25T00:00:00Cell Adhesion11.018187741307258e-0012020-09-25T00:00:002020-09-25T00:00:00Autophagy19.084608620418964e-0022020-09-25T00:00:002020-09-25T00:00:00Insurance Coverage17.943686496024376e-0022021-11-11T00:00:002021-11-11T00:00:00Beclin-114.133178917223798e-0022020-09-25T00:00:002020-09-25T00:00:00Autophagy-Related Protein-1 Homolog14.124488640923077e-0022020-09-25T00:00:002020-09-25T00:00:00I-kappa B Kinase13.767317515119536e-0022020-09-25T00:00:002020-09-25T00:00:00Primates13.550852799777425e-0022020-09-25T00:00:002020-09-25T00:00:00Amino Acid Motifs13.453122755955083e-0022020-09-25T00:00:002020-09-25T00:00:00RNA, Guide, CRISPR-Cas Systems13.274083573076752e-0022020-09-25T00:00:002020-09-25T00:00:00Substrate Specificity13.145247840099769e-0022020-09-25T00:00:002020-09-25T00:00:00Microtubule-Associated Proteins12.894310109095698e-0022020-09-25T00:00:002020-09-25T00:00:00Retrospective Studies22.875129011221743e-0022021-11-11T00:00:002021-12-10T00:00:00Microscopy, Fluorescence12.509226610878106e-0022020-09-25T00:00:002020-09-25T00:00:00Sirolimus12.505455167024246e-0022020-09-25T00:00:002020-09-25T00:00:00United States12.459384427446771e-0022021-11-11T00:00:002021-11-11T00:00:00Lipopolysaccharides12.349286061698585e-0022020-09-25T00:00:002020-09-25T00:00:00HEK293 Cells12.137942825566744e-0022020-09-25T00:00:002020-09-25T00:00:00Intracellular Signaling Peptides and Proteins12.028414705227338e-0022020-09-25T00:00:002020-09-25T00:00:00Phosphorylation11.911973825950833e-0022020-09-25T00:00:002020-09-25T00:00:00Humans31.178899184375183e-0022020-09-25T00:00:002021-12-10T00:00:00Surveys and Questionnaires19.737938996408639e-0032021-12-10T00:00:002021-12-10T00:00:00Animals14.373913702120064e-0032020-09-25T00:00:002020-09-25T00:00:00Maelys Joy Amat, M.D.MaelysAmat

BIDMC Div of Gen Med/Healthcare AssocE/Shapiro 6330 Brookline AveBoston, MA 02215617 667 9600

1BIDMCBeth Israel Deaconess Medical CenterMedicineAdm-House StaffAssistant Professor of Medicine, Part-timeAssistant Professorhttp://www.ncbi.nlm.nih.gov/pubmed/41123923Poverty, Food Insecurity, and Housing Instability Among US Health Care Workers. JAMA. 2026 Jan 06; 335(1):86-88.Zhong A, Gao C, Szlosek D, Nguyen D, Amat MJ, Phillips RS. JAMA2026 Jan 06335(1):86-88http://www.ncbi.nlm.nih.gov/pubmed/41489935Evaluation of a Telephone Outreach Intervention on Colonoscopy Completion Rates for Patients With Rectal Bleeding. J Healthc Qual. 2026 Jan-Mar 01; 48(1).Amat M, Huang D, Ricci D, Benneyan J, Flier S, Shanmugam H, Sternberg S, Pollack A, Fernandez L, Salant T, Aronson M, Schiff G, Phillips R. J Healthc Qual2026 Jan-Mar 0148(1)http://www.ncbi.nlm.nih.gov/pubmed/40659978Disability Status and Civic Engagement in the United States: An Analysis of the National Health Interview Survey. J Gen Intern Med. 2026 Jan; 41(1):249-251.Lin JC, Zhong A, Nguyen D, Zhang AL, Phillips RS, Amat MJ. J Gen Intern Med2026 Jan41(1):249-251http://www.ncbi.nlm.nih.gov/pubmed/40461739Differences in Ambulatory Care Outcomes Between Trainees and Faculty: A Multi-center Study. J Gen Intern Med. 2025 Aug; 40(11):2652-2660.Graham KL, Amat M, Norian E, Li J, Weintraub J, Shaik A, Boggan JC, Davy J, Lyons A, Semour L, Rogers R, Davis RB. J Gen Intern Med2025 Aug40(11):2652-2660http://www.ncbi.nlm.nih.gov/pubmed/40268315Patient Perspectives on Delayed Specialty Follow-Up After a Primary Care Visit. J Am Board Fam Med. 2025 May 12; 38(1):139-153.Fernández L, Ricci D, Pollack A, Amat MJ, Drielak M, Salant T, Schiff GD, Shafiq U, Sternberg SB, Benneyan J, Aronson M, Sullivan E, Phillips RS. J Am Board Fam Med2025 May 1238(1):139-153http://www.ncbi.nlm.nih.gov/pubmed/40167582A Phenome-Wide Association Study of Marijuana Use and Circulating Biomarkers in the United States: National Health and Nutrition Examination Survey 2009-2018. J Clin Pharmacol. 2025 Sep; 65(9):1127-1134.Zhang C, Mostofsky E, Zhang H, Zhang B, Lindenberg J, Amat MJ, Mukamal KJ. J Clin Pharmacol2025 Sep65(9):1127-1134http://www.ncbi.nlm.nih.gov/pubmed/40118545Implications of Sociodemographic and Clinical Factors Associated with Completion of Cardiac Stress Tests. J Am Board Fam Med. 2024 Nov-Dec; 37(6):1088-1094.Amat MJ, Zhong A, Zhang C, Gervino E, Wadhera R, Phillips RS. J Am Board Fam Med2024 Nov-Dec37(6):1088-1094http://www.ncbi.nlm.nih.gov/pubmed/38985494Marijuana Use and Hemoglobin Concentrations in NHANES 2009-2018: Implications for Subclinical Hypoxemia. Ann Am Thorac Soc. 2024 Nov; 21(11):1488-1495.Zhang C, Zhang H, Zhang B, Lindenberg J, Amat MJ, Rice MB, Mukamal KJ. Ann Am Thorac Soc2024 Nov21(11):1488-1495http://www.ncbi.nlm.nih.gov/pubmed/38671200Saving Primary Care: Developing a Practice Registry to Monitor the Health of a Threatened Profession. J Gen Intern Med. 2024 Aug; 39(11):1955-1958.Phillips RS, Amat M, Dave J. J Gen Intern Med2024 Aug39(11):1955-1958http://www.ncbi.nlm.nih.gov/pubmed/38573625Reported Political Participation by Physicians vs Nonphysicians. JAMA. 2024 04 23; 331(16):1413-1415.Zhong A, Jain B, Martin AF, Zhang C, Phillips RS, Amat MJ. JAMA2024 04 23331(16):1413-1415http://www.ncbi.nlm.nih.gov/pubmed/38164964Do patients who read visit notes on the patient portal have a higher rate of "loop closure" on diagnostic tests and referrals in primary care? A retrospective cohort study. J Am Med Inform Assoc. 2024 02 16; 31(3):622-630.Bell SK, Amat MJ, Anderson TS, Aronson MD, Benneyan JC, Fernandez L, Ricci DA, Salant T, Schiff GD, Shafiq U, Singer SJ, Sternberg SB, Zhang C, Phillips RS. J Am Med Inform Assoc2024 02 1631(3):622-630http://www.ncbi.nlm.nih.gov/pubmed/38358939An Analysis of Trainee Status of the Primary Care Physician and Ambulatory Care Outcomes. Acad Med. 2024 07 01; 99(7):750-755.Graham KL, Norian E, Li J, Amat M, Davis RB. Acad Med2024 07 0199(7):750-755http://www.ncbi.nlm.nih.gov/pubmed/37940753Completion Rates and Timeliness of Diagnostic Colonoscopies for Rectal Bleeding in Primary Care. J Gen Intern Med. 2024 May; 39(6):985-991.Campbell KA, Sternberg SB, Benneyan J, Flier SN, Amat M, Salant T, Nambara K, Fernandez L, Feuerstein J, Shafiq U, Phillips RS, Aronson MD, Schiff GD. J Gen Intern Med2024 May39(6):985-991http://www.ncbi.nlm.nih.gov/pubmed/37966837Completion of Recommended Tests and Referrals in Telehealth vs In-Person Visits. JAMA Netw Open. 2023 11 01; 6(11):e2343417.Zhong A, Amat MJ, Anderson TS, Shafiq U, Sternberg SB, Salant T, Fernandez L, Schiff GD, Aronson MD, Benneyan JC, Singer SJ, Phillips RS. JAMA Netw Open2023 11 016(11):e2343417http://www.ncbi.nlm.nih.gov/pubmed/37996308Low Rate of Completion of Recommended Tests and Referrals in an Academic Primary Care Practice with Resident Trainees. Jt Comm J Qual Patient Saf. 2024 03; 50(3):177-184.Amat MJ, Anderson TS, Shafiq U, Sternberg SB, Salant T, Fernandez L, Schiff GD, Aronson MD, Benneyan JC, Singer SJ, Graham KL, Phillips RS. Jt Comm J Qual Patient Saf2024 0350(3):177-184http://www.ncbi.nlm.nih.gov/pubmed/35257669Unmasking a Vulnerable Patient Care Process: A Qualitative Study Describing the Current State of Resident Continuity Clinic in a Nationwide Cohort of Internal Medicine Residency Programs. Am J Med. 2022 06; 135(6):783-786.Amat M, Norian E, Graham KL. Am J Med2022 06135(6):783-786http://www.ncbi.nlm.nih.gov/pubmed/35091918"Patient Lost to Follow-up": Opportunities and Challenges in Delivering Primary Care in Academic Medical Centers. J Gen Intern Med. 2022 08; 37(11):2678-2683.Amat M, Duralde E, Masutani R, Glassman R, Shen C, Graham KL. J Gen Intern Med2022 0837(11):2678-2683http://www.ncbi.nlm.nih.gov/pubmed/33969607Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver Int. 2021 08; 41(8):1901-1908.Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Rangel Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Liver Int2021 0841(8):1901-1908http://www.ncbi.nlm.nih.gov/pubmed/33479930Defining the Resident Continuity Clinic Panel Along Patient Outcomes: a Health Equity Opportunity. J Gen Intern Med. 2021 09; 36(9):2615-2621.Amat M, Glassman R, Basu N, Doolin J, Flier L, Gonzalez MR, Gosselin J, Knapp S, Yun P, Graham KL. J Gen Intern Med2021 0936(9):2615-2621http://www.ncbi.nlm.nih.gov/pubmed/33437494MIT COVID-19 Datathon: data without boundaries. BMJ Innov. 2021 Jan; 7(1):231-234.Luo EM, Newman S, Amat M, Charpignon ML, Duralde ER, Jain S, Kaufman AR, Korolev I, Lai Y, Lam BD, Lipcsey M, Martinez A, Mechanic OJ, Mlabasati J, McCoy LG, Nguyen FT, Samuel M, Yang E, Celi LA. BMJ Innov2021 Jan7(1):231-234Telephone17.420052649720332e-0012026-01-02T00:00:002026-01-02T00:00:00Gastrointestinal Hemorrhage37.003138301201379e-0012021-05-24T00:00:002026-01-02T00:00:00Lost to Follow-Up16.792545090988443e-0012022-01-28T00:00:002022-01-28T00:00:00Colonoscopy26.349712101145605e-0012023-11-08T00:00:002026-01-02T00:00:00Internship and Residency56.010814753580588e-0012021-01-21T00:00:002025-06-03T00:00:00Primary Health Care115.548987192827699e-0012021-01-21T00:00:002026-01-02T00:00:00Politics15.136731998834733e-0012024-04-23T00:00:002024-04-23T00:00:00Exercise Test14.980369041367557e-0012024-11-01T00:00:002024-11-01T00:00:00Physicians24.473467682468771e-0012022-01-28T00:00:002024-04-23T00:00:00Health Equity13.521555575290268e-0012021-01-21T00:00:002021-01-21T00:00:00Marijuana Use23.396983264871662e-0012024-11-01T00:00:002025-04-01T00:00:00Academic Medical Centers53.269062149761302e-0012022-01-28T00:00:002025-06-03T00:00:00Ambulatory Care Facilities22.217954711419269e-0012021-01-21T00:00:002022-03-05T00:00:00Appointments and Schedules22.210175735392504e-0012025-05-12T00:00:002026-01-02T00:00:00Sociodemographic Factors12.009316239347326e-0012024-11-01T00:00:002024-11-01T00:00:00Ambulatory Care21.998485697641561e-0012024-02-14T00:00:002025-06-03T00:00:00Referral and Consultation31.907884711922824e-0012023-10-24T00:00:002025-05-12T00:00:00Patient Portals11.645109147166200e-0012024-02-16T00:00:002024-02-16T00:00:00Nutrition Surveys21.626683240787959e-0012024-11-01T00:00:002025-04-01T00:00:00Faculty, Medical21.518779372760060e-0012024-02-14T00:00:002025-06-03T00:00:00Esophageal and Gastric Varices11.464802000084585e-0012021-05-24T00:00:002021-05-24T00:00:00Hemoglobins11.409227919768034e-0012024-11-01T00:00:002024-11-01T00:00:00Internal Medicine21.314059556992768e-0012021-01-21T00:00:002024-02-14T00:00:00Physicians, Primary Care11.298236884833908e-0012024-02-14T00:00:002024-02-14T00:00:00End Stage Liver Disease11.236491645893915e-0012021-05-24T00:00:002021-05-24T00:00:00Patient Care11.223613655876606e-0012022-03-05T00:00:002022-03-05T00:00:00Hypoxia11.169980654279931e-0012024-11-01T00:00:002024-11-01T00:00:00Retrospective Studies81.106621098240897e-0012021-05-24T00:00:002025-06-03T00:00:00Qualitative Research21.024698660132122e-0012022-03-05T00:00:002025-05-12T00:00:00Continuity of Patient Care11.001828352633492e-0012021-01-21T00:00:002021-01-21T00:00:00Middle Aged109.121363929478822e-0022023-11-01T00:00:002026-01-02T00:00:00Aged89.109301889366411e-0022023-11-01T00:00:002026-01-02T00:00:00Humans178.617910933079066e-0022021-01-21T00:00:002026-01-02T00:00:00Sex Factors18.254354789777918e-0022024-11-01T00:00:002024-11-01T00:00:00Male107.095945978682416e-0022023-11-01T00:00:002026-01-02T00:00:00United States46.960387135699041e-0022022-03-05T00:00:002025-04-01T00:00:00Adult86.768635431890639e-0022023-11-08T00:00:002026-01-02T00:00:00Registries16.726811250126638e-0022024-08-01T00:00:002024-08-01T00:00:00Female106.716142725911484e-0022023-11-01T00:00:002026-01-02T00:00:00Telemedicine15.923835274005160e-0022023-11-01T00:00:002023-11-01T00:00:00Coronary Artery Disease15.530103269968921e-0022024-11-01T00:00:002024-11-01T00:00:00Surveys and Questionnaires14.590058246172459e-0022024-04-23T00:00:002024-04-23T00:00:00Marijuana Smoking14.188478343918663e-0022024-11-01T00:00:002024-11-01T00:00:00Blood Component Transfusion14.094070310980455e-0022021-05-24T00:00:002021-05-24T00:00:00Reading13.959532447757694e-0022024-02-16T00:00:002024-02-16T00:00:00Cigarette Smoking13.809017237272799e-0022024-11-01T00:00:002024-11-01T00:00:00Child, Preschool13.559977215448862e-0022022-01-28T00:00:002022-01-28T00:00:00Chest Pain13.507525395022691e-0022025-05-12T00:00:002025-05-12T00:00:00Diagnostic Tests, Routine13.445949482731954e-0022024-02-16T00:00:002024-02-16T00:00:00Plasma13.422438596148162e-0022021-05-24T00:00:002021-05-24T00:00:00Cohort Studies33.100794650348362e-0022021-05-24T00:00:002025-06-03T00:00:00Electronic Health Records23.074511257660989e-0022024-02-16T00:00:002025-05-12T00:00:00Social Determinants of Health12.747421562998310e-0022024-02-14T00:00:002024-02-14T00:00:00Time Factors22.367301718586651e-0022023-11-08T00:00:002025-05-12T00:00:00Physician-Patient Relations12.217221118658876e-0022025-05-12T00:00:002025-05-12T00:00:00Boston12.082960083751858e-0022023-11-01T00:00:002023-11-01T00:00:00Communication11.990435567025228e-0022025-05-12T00:00:002025-05-12T00:00:00Young Adult21.669602675885935e-0022024-11-01T00:00:002025-04-01T00:00:00Healthcare Disparities11.598459731436138e-0022024-02-14T00:00:002024-02-14T00:00:00Phenotype11.597832397102084e-0022025-04-01T00:00:002025-04-01T00:00:00Adolescent21.504875805596428e-0022024-11-01T00:00:002025-04-01T00:00:00Severity of Illness Index11.228133405110785e-0022021-05-24T00:00:002021-05-24T00:00:00Biomarkers11.209853202397312e-0022025-04-01T00:00:002025-04-01T00:00:00Cross-Sectional Studies11.205777764053500e-0022024-11-01T00:00:002024-11-01T00:00:00Rocco Amendolara, Ph.D.RoccoAmendolara

Joslin Diabetes Center One Joslin PlaceBoston, MA 02215617/309-2400

1BIDMCBeth Israel Deaconess Medical CenterMedicineJoslinResearch Fellow in MedicineFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41618706Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta-analysis. Diabet Med. 2026 Jan 31; e70236.Franceschi R, Mozzillo E, Marigliano M, Maltoni G, Maddaloni E, Amendolara R, Bernardini L, Bonfanti R, Ciambrelli F, Di Candia F, Fedi L, Fierro A, Iafusco D, Iannilli A, Leonardi L, Maffeis C, Maines E, Pertile R, Piona C, Rabbone I, Ripoli C, Scozzarella A, Tiberi V, Buzzetti R, Cherubini V. Diabet Med2026 Jan 31e70236http://www.ncbi.nlm.nih.gov/pubmed/40930318Liver disease in people with latent autoimmune diabetes in adults (LADA): A cross-sectional study using magnetic resonance elastography. Diabetes Res Clin Pract. 2025 Nov; 229:112465.Maddaloni E, Zerunian M, Cardinale V, Zurru A, Amendolara R, Luverà D, Risi R, D'Onofrio L, Masci B, Covotta F, Caruso D, Alvaro D, Laghi A, Buzzetti R. Diabetes Res Clin Pract2025 Nov229:112465http://www.ncbi.nlm.nih.gov/pubmed/39760686IFN-a Neutralizing Antibodies Distinguish LADA From Early-onset Type 1 Diabetes. J Clin Endocrinol Metab. 2025 Aug 07; 110(9):2565-2572.Amendolara R, D'Onofrio L, Sessa RL, Di Giulio S, Mignogna C, Coraggio L, Schirano R, Zampetti S, Malandrucco I, Pozzilli P, Giannini G, Maddaloni E, Buzzetti R. J Clin Endocrinol Metab2025 Aug 07110(9):2565-2572http://www.ncbi.nlm.nih.gov/pubmed/40718585The Emerging Role of Anti-Hyperglycemic Agents for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease. Diabetes Metab Syndr Obes. 2025; 18:2477-2491.Pieralice S, Amendolara R, Berna V, Manganaro G, Zurru A, D'Onofrio L, Risi R, Alfonsi M, Maddaloni E, Buzzetti R. Diabetes Metab Syndr Obes202518:2477-2491http://www.ncbi.nlm.nih.gov/pubmed/40139321Osteocalcin is inversely associated with worse adipose tissue distribution and cardiovascular risk in autoimmune diabetes. Diabetes Res Clin Pract. 2025 May; 223:112114.Risi R, Amendolara R, Balena A, Watanabe M, Masi D, Fassino V, Luverà D, D'Onofrio L, Lauria A, Zampetti S, Gnessi L, Maddaloni E, Buzzetti R. Diabetes Res Clin Pract2025 May223:112114http://www.ncbi.nlm.nih.gov/pubmed/39953513Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes. Cardiovasc Diabetol. 2025 Feb 14; 24(1):74.Risi R, Amendolara R, Pantano AL, Fassino V, D'Onofrio L, Coraggio L, Luverà D, Masi D, Watanabe M, Gnessi L, Buzzetti R, Maddaloni E. Cardiovasc Diabetol2025 Feb 1424(1):74http://www.ncbi.nlm.nih.gov/pubmed/39863081Residual C-peptide secretion is associated with better CGM-metrics in adults with short-lasting type 1 diabetes. Diabetes Res Clin Pract. 2025 Mar; 221:112006.Amendolara R, Zampetti S, Siena A, D'Onofrio L, De Vita F, Barbaro F, Notarnicola D, Sessa RL, Luverà D, Risi R, Maddaloni E, Buzzetti R. Diabetes Res Clin Pract2025 Mar221:112006http://www.ncbi.nlm.nih.gov/pubmed/38964935No Differences in Kidney Function Decline Between People With Type 2 Diabetes Starting a Sodium-Glucose Cotransporter 2 Inhibitor or a Glucagon-like Peptide-1 Receptor Agonist: A Real-world Retrospective Comparative Observational Study. Clin Ther. 2024 Nov; 46(11):828-834.Bodini S, Pieralice S, D'Onofrio L, Mignogna C, Coraggio L, Amendolara R, Risi R, Salducci M, Buzzetti R, Maddaloni E. Clin Ther2024 Nov46(11):828-834http://www.ncbi.nlm.nih.gov/pubmed/38599622Over-the-scope clip as first-line treatment of peptic ulcer bleeding: a multicenter randomized controlled trial (TOP Study). Endoscopy. 2024 Sep; 56(9):665-673.Soriani P, Biancheri P, Bonura GF, Gabbani T, Rodriguez de Santiago E, Dioscoridi L, Andrisani G, Luigiano C, Deiana S, Rainer J, Del Buono M, Amendolara R, Marino M, Hassan C, Repici A, Manno M. Endoscopy2024 Sep56(9):665-673http://www.ncbi.nlm.nih.gov/pubmed/38427915Immune checkpoint modulators in early clinical development for the treatment of type 1 diabetes. Expert Opin Investig Drugs. 2024 Apr; 33(4):303-318.Maddaloni E, Amendolara R, Balena A, Latino A, Sessa RL, Buzzetti R. Expert Opin Investig Drugs2024 Apr33(4):303-318http://www.ncbi.nlm.nih.gov/pubmed/38297915Saxagliptin/dapagliflozin is non-inferior to insulin glargine in terms of ß-cell function in subjects with latent autoimmune diabetes in adults: A 12-month, randomized, comparator-controlled pilot study. Diabetes Obes Metab. 2024 May; 26(5):1670-1677.Maddaloni E, Naciu AM, Mignogna C, Galiero R, Amendolara R, Fogolari M, Satta C, Serafini C, Angeletti S, Cavallo MG, Cossu E, Sasso FC, Buzzetti R, Pozzilli P. Diabetes Obes Metab2024 May26(5):1670-1677http://www.ncbi.nlm.nih.gov/pubmed/37958794Lack of Association between Serum Chitotriosidase Activity and Arterial Stiffness in Type 2 Diabetes without Cardiovascular Complications. Int J Mol Sci. 2023 Oct 31; 24(21).D'Onofrio L, Amendolara R, Mignogna C, Leto G, Tartaglione L, Mazzaferro S, Maddaloni E, Buzzetti R. Int J Mol Sci2023 Oct 3124(21)http://www.ncbi.nlm.nih.gov/pubmed/36880127Association of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease and retinopathy in type 2 diabetes. Diabetes Metab Res Rev. 2023 07; 39(5):e3632.Maddaloni E, Coraggio L, Amendolara R, Baroni MG, Cavallo MG, Copetti M, Cossu E, D'Angelo P, D'Onofrio L, Cosmo S, Leonetti F, Morano S, Morviducci L, Napoli N, Prudente S, Pugliese G, Park K, Holman RR, Trischitta V, Buzzetti R. Diabetes Metab Res Rev2023 0739(5):e3632http://www.ncbi.nlm.nih.gov/pubmed/36533777Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: The CoVaDiab study I. Diabetes Metab Res Rev. 2023 03; 39(3):e3601.D'Onofrio L, Fogolari M, Amendolara R, Siena A, De Fata R, Davini F, Coraggio L, Mignogna C, Moretti C, Maddaloni E, Angeletti S, Buzzetti R. Diabetes Metab Res Rev2023 0339(3):e3601http://www.ncbi.nlm.nih.gov/pubmed/34273056Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19: a systematic review and meta-analysis. Intern Emerg Med. 2021 10; 16(7):1975-1985.Maddaloni E, D'Onofrio L, Siena A, Luordi C, Mignogna C, Amendolara R, Cavallari I, Grigioni F, Buzzetti R. Intern Emerg Med2021 1016(7):1975-1985http://www.ncbi.nlm.nih.gov/pubmed/29197134Assessment of cardiovascular risk in an Italian psychiatric outpatient sample: A chart review of patients treated with second-generation antipsychotics. Int J Ment Health Nurs. 2018 Jun; 27(3):1002-1008.Severi E, Ferrara M, Tedeschini E, Vacca F, Mungai F, Amendolara R, Baccari F, Starace F. Int J Ment Health Nurs2018 Jun27(3):1002-1008Latent Autoimmune Diabetes in Adults31.384105333698783e+0002024-01-31T00:00:002025-09-08T00:00:00Diabetes Mellitus, Type 171.013869368410593e+0002022-12-27T00:00:002025-09-08T00:00:00C-Peptide28.204059954230762e-0012024-01-31T00:00:002025-01-23T00:00:00Interferon-alpha16.830700097482156e-0012025-08-07T00:00:002025-08-07T00:00:00Autoantibodies14.848085508249095e-0012025-08-07T00:00:002025-08-07T00:00:00Antibodies, Neutralizing14.545036439581196e-0012025-08-07T00:00:002025-08-07T00:00:00Blood Glucose33.505798764345003e-0012017-12-02T00:00:002025-01-23T00:00:00Diabetes Mellitus, Type 272.747174307821269e-0012022-12-27T00:00:002025-09-08T00:00:00Osteocalcin22.631649400497930e-0012023-03-20T00:00:002025-03-24T00:00:00Body Fat Distribution22.516681104925583e-0012025-02-14T00:00:002025-03-24T00:00:00Peptic Ulcer Hemorrhage12.108949368741562e-0012024-04-10T00:00:002024-04-10T00:00:00Hemostasis, Endoscopic12.046146862435065e-0012024-04-10T00:00:002024-04-10T00:00:00Intra-Abdominal Fat21.944511073451139e-0012025-02-14T00:00:002025-09-08T00:00:00Adamantane11.934087806117462e-0012024-01-31T00:00:002024-01-31T00:00:00Autonomic Nervous System Diseases11.833138598071908e-0012025-02-14T00:00:002025-02-14T00:00:00Surgical Instruments11.761272972276713e-0012024-04-10T00:00:002024-04-10T00:00:00Diabetic Neuropathies11.723478483622279e-0012025-02-14T00:00:002025-02-14T00:00:00Dipeptides11.722963202193798e-0012024-01-31T00:00:002024-01-31T00:00:00Blood Glucose Self-Monitoring11.647489720814294e-0012025-01-23T00:00:002025-01-23T00:00:00Cardiovascular Diseases51.523334616110720e-0012017-12-02T00:00:002025-03-24T00:00:00Vascular Stiffness11.489576818128594e-0012023-10-31T00:00:002023-10-31T00:00:00Glucagon-Like Peptide-1 Receptor Agonists11.410394927853897e-0012024-07-04T00:00:002024-07-04T00:00:00Glucosides11.395480870886252e-0012024-01-31T00:00:002024-01-31T00:00:00Adiposity21.393494879326150e-0012025-02-14T00:00:002025-09-08T00:00:00Insulin-Secreting Cells11.392094104259245e-0012025-01-23T00:00:002025-01-23T00:00:00Age of Onset11.384906445673592e-0012025-08-07T00:00:002025-08-07T00:00:00Fatty Liver11.353726231116138e-0012025-09-08T00:00:002025-09-08T00:00:00Hypoglycemia11.316979360650882e-0012025-01-23T00:00:002025-01-23T00:00:00Diabetic Nephropathies11.287669246677656e-0012024-07-04T00:00:002024-07-04T00:00:00Benzhydryl Compounds11.249889046970951e-0012024-01-31T00:00:002024-01-31T00:00:00Metformin11.200781205667684e-0012024-01-31T00:00:002024-01-31T00:00:00Glomerular Filtration Rate11.156608812287441e-0012024-07-04T00:00:002024-07-04T00:00:00Vascular Diseases11.097130256897451e-0012023-03-20T00:00:002023-03-20T00:00:00Sodium-Glucose Transporter 2 Inhibitors19.981490000171468e-0022024-07-04T00:00:002024-07-04T00:00:00Adipose Tissue19.646372347173847e-0022025-03-24T00:00:002025-03-24T00:00:00Diabetic Retinopathy19.441728348721003e-0022023-03-20T00:00:002023-03-20T00:00:00Heart Diseases18.968967620720543e-0022025-02-14T00:00:002025-02-14T00:00:00Heart18.945296760249200e-0022025-02-14T00:00:002025-02-14T00:00:00Recurrence18.818804652239080e-0022024-04-10T00:00:002024-04-10T00:00:00Cross-Sectional Studies48.533468588055725e-0022023-10-31T00:00:002025-09-08T00:00:00Diagnosis, Differential18.008936532819654e-0022025-08-07T00:00:002025-08-07T00:00:00Absorptiometry, Photon27.526553348539056e-0022025-02-14T00:00:002025-09-08T00:00:00Critical Care17.047901063599804e-0022021-07-17T00:00:002021-07-17T00:00:00Young Adult26.813946160012258e-0022025-01-23T00:00:002025-08-07T00:00:00Middle Aged86.653688404638457e-0022017-12-02T00:00:002025-09-08T00:00:00Adult65.886358664095119e-0022024-01-31T00:00:002025-09-08T00:00:00Male95.502714060575463e-0022017-12-02T00:00:002025-09-08T00:00:00Antipsychotic Agents15.432569344777947e-0022017-12-02T00:00:002017-12-02T00:00:00Duodenal Ulcer15.231459633727278e-0022024-04-10T00:00:002024-04-10T00:00:00Hexosaminidases15.228665056895542e-0022023-10-31T00:00:002023-10-31T00:00:00Female95.208186917111644e-0022017-12-02T00:00:002025-09-08T00:00:00Stomach Ulcer15.171522420767712e-0022024-04-10T00:00:002024-04-10T00:00:00Insulin Glargine15.001541421375698e-0022024-01-31T00:00:002024-01-31T00:00:00Humans144.728452065514553e-0022017-12-02T00:00:002025-09-08T00:00:00Pulse Wave Analysis14.577411482517037e-0022023-10-31T00:00:002023-10-31T00:00:00COVID-1924.479103639801692e-0022021-07-17T00:00:002022-12-27T00:00:00Risk Assessment24.260892658233424e-0022017-12-02T00:00:002025-02-14T00:00:00Osteopontin14.234435761425354e-0022023-03-20T00:00:002023-03-20T00:00:00Pilot Projects24.205871498786851e-0022024-01-31T00:00:002025-09-08T00:00:00Hypoglycemic Agents24.083290796609181e-0022024-01-31T00:00:002024-07-04T00:00:00Elasticity Imaging Techniques13.949239527385662e-0022025-09-08T00:00:002025-09-08T00:00:00Heart Disease Risk Factors13.840268949434778e-0022025-03-24T00:00:002025-03-24T00:00:00gamma-Glutamyltransferase13.307838787095958e-0022017-12-02T00:00:002017-12-02T00:00:00Risk Factors43.290381507454586e-0022023-10-31T00:00:002025-09-08T00:00:00Mental Disorders13.285892539918175e-0022017-12-02T00:00:002017-12-02T00:00:00Child13.174009745700080e-0022025-08-07T00:00:002025-08-07T00:00:00Adolescent13.127937342457624e-0022025-08-07T00:00:002025-08-07T00:00:00Autoimmunity12.968608060497171e-0022024-03-13T00:00:002024-03-13T00:00:00Italy12.888521034185593e-0022017-12-02T00:00:002017-12-02T00:00:00Antibodies12.784255923037185e-0022022-12-27T00:00:002022-12-27T00:00:00Immunologic Factors12.755452964594872e-0022024-03-13T00:00:002024-03-13T00:00:00Lipoproteins, LDL12.699211108044186e-0022017-12-02T00:00:002017-12-02T00:00:00Aged52.690273913742734e-0022024-04-10T00:00:002025-09-08T00:00:00RNA, Viral12.669775967559134e-0022022-12-27T00:00:002022-12-27T00:00:00Glycated Hemoglobin12.658859192666093e-0022024-01-31T00:00:002024-01-31T00:00:00Drug Therapy, Combination12.579329092426288e-0022024-01-31T00:00:002024-01-31T00:00:00Waist Circumference12.560953979308696e-0022017-12-02T00:00:002017-12-02T00:00:00Lipoproteins, HDL12.517272730780693e-0022017-12-02T00:00:002017-12-02T00:00:00Biomarkers22.258760703373998e-0022023-03-20T00:00:002025-03-24T00:00:00Respiration, Artificial11.990023134604011e-0022021-07-17T00:00:002021-07-17T00:00:00Outpatients11.968135656355684e-0022017-12-02T00:00:002017-12-02T00:00:00Triglycerides11.966682003871084e-0022017-12-02T00:00:002017-12-02T00:00:00Vaccination11.950955010916233e-0022022-12-27T00:00:002022-12-27T00:00:00Insulin11.916561451460124e-0022024-03-13T00:00:002024-03-13T00:00:00Double-Blind Method11.901925906822221e-0022024-01-31T00:00:002024-01-31T00:00:00Liver11.901500991701861e-0022025-09-08T00:00:002025-09-08T00:00:00Kidney11.801051503873778e-0022024-07-04T00:00:002024-07-04T00:00:00COVID-19 Vaccines11.790945350545214e-0022022-12-27T00:00:002022-12-27T00:00:00Cholesterol11.774669163275342e-0022017-12-02T00:00:002017-12-02T00:00:00Prevalence11.730531863349954e-0022025-09-08T00:00:002025-09-08T00:00:00Intensive Care Units11.690866713345420e-0022021-07-17T00:00:002021-07-17T00:00:00Body Mass Index11.682857393081462e-0022025-09-08T00:00:002025-09-08T00:00:00Immunotherapy11.628488456267525e-0022024-03-13T00:00:002024-03-13T00:00:00Treatment Outcome21.589360557205899e-0022024-01-31T00:00:002024-04-10T00:00:00Comorbidity11.584038891189830e-0022021-07-17T00:00:002021-07-17T00:00:00Metabolic Syndrome11.561477906441841e-0022017-12-02T00:00:002017-12-02T00:00:00Quality of Life11.118820806808121e-0022024-03-13T00:00:002024-03-13T00:00:00Blood Pressure11.100850820959495e-0022017-12-02T00:00:002017-12-02T00:00:00Follow-Up Studies11.066019149843722e-0022022-12-27T00:00:002022-12-27T00:00:00SARS-CoV-211.042438411946018e-0022022-12-27T00:00:002022-12-27T00:00:00Aged, 80 and over18.739793251283504e-0032024-04-10T00:00:002024-04-10T00:00:00Magnetic Resonance Imaging18.440657243264371e-0032025-09-08T00:00:002025-09-08T00:00:00Retrospective Studies16.899594746117537e-0032024-07-04T00:00:002024-07-04T00:00:00Yolanda Amezaga, M.D.YolandaAmezaga

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post DocSahil Amin, M.D.SahilAmin

Beth Israel Deaconess Medical Center 330 Brookline AveBoston, MA 02215617/667-7000

1BIDMCBeth Israel Deaconess Medical CenterAnaesthesiaResidentsClinical Fellow in AnaesthesiaFellow or Post Dochttp://www.ncbi.nlm.nih.gov/pubmed/41032450Gene Therapy in the Setting of Chronic Pain Medicine. Anesth Analg. 2026 Feb 01; 142(2):306-308.Beniwal A, Amin S, Remotti EJ, Woolley PA, Chen F, Emerick T. Anesth Analg2026 Feb 01142(2):306-308Oren Amsalem, Ph.D.OrenAmsalem

Center for Life Science Room 7246 3 Blackfan CircleBoston, MA 02115617 735 3343

1BIDMCBeth Israel Deaconess Medical CenterMedicineEndocrinologyResearch Fellow in MedicineFellow or Post Dochttps://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx?NodeID=173884977Oren_Amsalemhttp://www.ncbi.nlm.nih.gov/pubmed/40316528Using an algorithmic approach to shape human decision-making through attraction to patterns. Nat Commun. 2025 May 02; 16(1):4110.Shani-Narkiss H, Eitam B, Amsalem O. Nat Commun2025 May 0216(1):4110http://www.ncbi.nlm.nih.gov/pubmed/39896634Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope. bioRxiv. 2025 Jan 30.Kalugin PN, Soden PA, Massengill CI, Amsalem O, Porniece M, Guarino DC, Tingley D, Zhang SX, Benson JC, Hammell MF, Tong DM, Ausfahl CD, Lacey TE, Courtney Y, Hochstetler A, Lutas A, Wang H, Geng L, Li G, Li B, Li Y, Lehtinen MK, Andermann ML. bioRxiv2025 Jan 30http://www.ncbi.nlm.nih.gov/pubmed/39567784A spatial human thymus cell atlas mapped to a continuous tissue axis. Nature. 2024 Nov; 635(8039):708-718.Yayon N, Kedlian VR, Boehme L, Suo C, Wachter BT, Beuschel RT, Amsalem O, Polanski K, Koplev S, Tuck E, Dann E, Van Hulle J, Perera S, Putteman T, Predeus AV, Dabrowska M, Richardson L, Tudor C, Kreins AY, Engelbert J, Stephenson E, Kleshchevnikov V, De Rita F, Crossland D, Bosticardo M, Pala F, Prigmore E, Chipampe NJ, Prete M, Fei L, To K, Barker RA, He X, Van Nieuwerburgh F, Bayraktar OA, Patel M, Davies EG, Haniffa MA, Uhlmann V, Notarangelo LD, Germain RN, Radtke AJ, Marioni JC, Taghon T, Teichmann SA. Nature2024 Nov635(8039):708-718http://www.ncbi.nlm.nih.gov/pubmed/39261492Sub-threshold neuronal activity and the dynamical regime of cerebral cortex. Nat Commun. 2024 09 11; 15(1):7958.Amsalem O, Inagaki H, Yu J, Svoboda K, Darshan R. Nat Commun2024 09 1115(1):7958http://www.ncbi.nlm.nih.gov/pubmed/38642553Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice. Neuron. 2024 Jul 03; 112(13):2130-2141.e7.Kucukdereli H, Amsalem O, Pottala T, Lim M, Potgieter L, Hasbrouck A, Lutas A, Andermann ML. Neuron2024 Jul 03112(13):2130-2141.e7http://www.ncbi.nlm.nih.gov/pubmed/38438345A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. Nat Commun. 2024 Mar 04; 15(1):1966.Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, Brannigan C, Resch JM, Jacobs CL, Pant D, Veregge M, Srinivasan H, Grippo RM, Yang Z, Zeidel ML, Andermann ML, Harris KD, Tsai LT, Arrigoni E, Verstegen AMJ, Saper CB, Lowell BB. Nat Commun2024 Mar 0415(1):1966http://www.ncbi.nlm.nih.gov/pubmed/38093002Cortical reactivations predict future sensory responses. Nature. 2024 01; 625(7993):110-118.Nguyen ND, Lutas A, Amsalem O, Fernando J, Ahn AY, Hakim R, Vergara J, McMahon J, Dimidschstein J, Sabatini BL, Andermann ML. Nature2024 01625(7993):110-118http://www.ncbi.nlm.nih.gov/pubmed/38014113A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. bioRxiv. 2023 Nov 17.Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, Brannigan C, Resch JM, Jacobs CL, Pant D, Veregge M, Srinivasan H, Grippo RM, Yang Z, Zeidel ML, Andermann ML, Harris KD, Tsai LT, Arrigoni E, Verstegen AMJ, Saper CB, Lowell BB. bioRxiv2023 Nov 17http://www.ncbi.nlm.nih.gov/pubmed/37986877A spatial human thymus cell atlas mapped to a continuous tissue axis. bioRxiv. 2023 Oct 27.Yayon N, Kedlian VR, Boehme L, Suo C, Wachter B, Beuschel RT, Amsalem O, Polanski K, Koplev S, Tuck E, Dann E, Van Hulle J, Perera S, Putteman T, Predeus AV, Dabrowska M, Richardson L, Tudor C, Kreins AY, Engelbert J, Stephenson E, Kleshchevnikov V, De Rita F, Crossland D, Bosticardo M, Pala F, Prigmore E, Chipampe NJ, Prete M, Fei L, To K, Barker RA, He X, Van Nieuwerburgh F, Bayraktar O, Patel M, Davies GE, Haniffa MA, Uhlmann V, Notarangelo LD, Germain RN, Radtke AJ, Marioni JC, Taghon T, Teichmann SA. bioRxiv2023 Oct 27http://www.ncbi.nlm.nih.gov/pubmed/37292650Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice. bioRxiv. 2023 May 17.Kucukdereli H, Amsalem O, Pottala T, Lim M, Potgieter L, Hasbrouck A, Lutas A, Andermann ML. bioRxiv2023 May 17http://www.ncbi.nlm.nih.gov/pubmed/36867532Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep. Cell Rep. 2023 03 28; 42(3):112200.Iavarone E, Simko J, Shi Y, Bertschy M, García-Amado M, Litvak P, Kaufmann AK, O'Reilly C, Amsalem O, Abdellah M, Chevtchenko G, Coste B, Courcol JD, Ecker A, Favreau C, Fleury AC, Van Geit W, Gevaert M, Guerrero NR, Herttuainen J, Ivaska G, Kerrien S, King JG, Kumbhar P, Lurie P, Magkanaris I, Muddapu VR, Nair J, Pereira FL, Perin R, Petitjean F, Ranjan R, Reimann M, Soltuzu L, Sy MF, Tuncel MA, Ulbrich A, Wolf M, Clascá F, Markram H, Hill SL. Cell Rep2023 03 2842(3):112200http://www.ncbi.nlm.nih.gov/pubmed/36377476High-throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory-deprived cortical cholinergic VIP/CHAT neurons. EMBO J. 2023 01 04; 42(1):e110565.Yayon N, Amsalem O, Zorbaz T, Yakov O, Dubnov S, Winek K, Dudai A, Adam G, Schmidtner AK, Tessier-Lavigne M, Renier N, Habib N, Segev I, London M, Soreq H. EMBO J2023 01 0442(1):e110565http://www.ncbi.nlm.nih.gov/pubmed/35650191A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex. Nat Commun. 2022 06 01; 13(1):3038.Chindemi G, Abdellah M, Amsalem O, Benavides-Piccione R, Delattre V, Doron M, Ecker A, Jaquier AT, King J, Kumbhar P, Monney C, Perin R, Rössert C, Tuncel AM, Van Geit W, DeFelipe J, Graupner M, Segev I, Markram H, Muller EB. Nat Commun2022 06 0113(1):3038http://www.ncbi.nlm.nih.gov/pubmed/35402905Statistical Emulation of Neural Simulators: Application to Neocortical L2/3 Large Basket Cells. Front Big Data. 2022; 5:789962.Shapira G, Marcus-Kalish M, Amsalem O, Van Geit W, Segev I, Steinberg DM. Front Big Data20225:789962http://www.ncbi.nlm.nih.gov/pubmed/35245458Visual association cortex links cues with conjunctions of reward and locomotor contexts. Curr Biol. 2022 04 11; 32(7):1563-1576.e8.McGuire KL, Amsalem O, Sugden AU, Ramesh RN, Fernando J, Burgess CR, Andermann ML. Curr Biol2022 04 1132(7):1563-1576.e8http://www.ncbi.nlm.nih.gov/pubmed/34968385Realistic retinal modeling unravels the differential role of excitation and inhibition to starburst amacrine cells in direction selectivity. PLoS Comput Biol. 2021 12; 17(12):e1009754.Ezra-Tsur E, Amsalem O, Ankri L, Patil P, Segev I, Rivlin-Etzion M. PLoS Comput Biol2021 1217(12):e1009754http://www.ncbi.nlm.nih.gov/pubmed/34630046The Role of Hub Neurons in Modulating Cortical Dynamics. Front Neural Circuits. 2021; 15:718270.Gal E, Amsalem O, Schindel A, London M, Schürmann F, Markram H, Segev I. Front Neural Circuits202115:718270http://www.ncbi.nlm.nih.gov/pubmed/32043972Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network. Elife. 2020 02 11; 9.Lefler Y, Amsalem O, Vrieler N, Segev I, Yarom Y. Elife2020 02 119http://www.ncbi.nlm.nih.gov/pubmed/31941884An efficient analytical reduction of detailed nonlinear neuron models. Nat Commun. 2020 01 15; 11(1):288.Amsalem O, Eyal G, Rogozinski N, Gevaert M, Kumbhar P, Schürmann F, Segev I. Nat Commun2020 01 1511(1):288http://www.ncbi.nlm.nih.gov/pubmed/29523815Intensify3D: Normalizing signal intensity in large heterogenic image stacks. Sci Rep. 2018 03 09; 8(1):4311.Yayon N, Dudai A, Vrieler N, Amsalem O, London M, Soreq H. Sci Rep2018 03 098(1):4311http://www.ncbi.nlm.nih.gov/pubmed/27288316From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells. Cereb Cortex. 2016 08; 26(8):3655-3668.Amsalem O, Van Geit W, Muller E, Markram H, Segev I. Cereb Cortex2016 0826(8):3655-3668Models, Neurological51.123590472958328e+0002016-06-09T00:00:002024-09-11T00:00:00Nonlinear Dynamics15.307110147432110e-0012020-01-15T00:00:002020-01-15T00:00:00Neocortex25.194915669817635e-0012016-06-09T00:00:002022-06-01T00:00:00Action Potentials15.176301928619833e-0012024-09-11T00:00:002024-09-11T00:00:00Neurons65.007751526497241e-0012020-01-15T00:00:002024-09-11T00:00:00Gap Junctions14.359166865625981e-0012016-06-09T00:00:002016-06-09T00:00:00Decision Making24.220871696240588e-0012024-09-11T00:00:002025-05-02T00:00:00Synapses34.114607563632151e-0012016-06-09T00:00:002021-09-24T00:00:00Dendrites34.059672855712362e-0012016-06-09T00:00:002024-09-11T00:00:00Interneurons23.716366600449474e-0012016-06-09T00:00:002022-11-15T00:00:00Neural Networks, Computer13.400433741472542e-0012020-01-15T00:00:002020-01-15T00:00:00Membrane Potentials22.738255659757793e-0012016-06-09T00:00:002024-09-11T00:00:00Algorithms32.618290270393872e-0012020-01-15T00:00:002025-05-02T00:00:00Visual Cortex22.278250980610581e-0012022-03-03T00:00:002023-12-13T00:00:00Pontine Tegmentum12.122696668949625e-0012024-03-04T00:00:002024-03-04T00:00:00Thymocytes12.067788390673524e-0012024-11-20T00:00:002024-11-20T00:00:00Starvation12.046055518978634e-0012024-04-19T00:00:002024-04-19T00:00:00Agouti-Related Protein12.033290040514260e-0012024-04-19T00:00:002024-04-19T00:00:00Parabrachial Nucleus11.971922659805459e-0012024-03-04T00:00:002024-03-04T00:00:00Ascomycota11.964177435948141e-0012024-03-04T00:00:002024-03-04T00:00:00Amacrine Cells11.806847613418367e-0012021-12-30T00:00:002021-12-30T00:00:00Memory Consolidation11.698532467596507e-0012023-12-13T00:00:002023-12-13T00:00:00Reward21.629930140916344e-0012022-03-03T00:00:002025-05-02T00:00:00Long-Term Potentiation11.623960910079173e-0012022-06-01T00:00:002022-06-01T00:00:00alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid11.596412299659198e-0012020-01-15T00:00:002020-01-15T00:00:00Thymus Gland11.548099927039905e-0012024-11-20T00:00:002024-11-20T00:00:00N-Methylaspartate11.512897918119359e-0012020-01-15T00:00:002020-01-15T00:00:00Olivary Nucleus11.485838863337409e-0012020-02-11T00:00:002020-02-11T00:00:00Spatio-Temporal Analysis11.446750243434025e-0012020-01-15T00:00:002020-01-15T00:00:00Frontal Lobe11.389504732620403e-0012024-09-11T00:00:002024-09-11T00:00:00Parietal Lobe11.341362277654681e-0012022-11-15T00:00:002022-11-15T00:00:00Visual Pathways11.316372984337811e-0012021-12-30T00:00:002021-12-30T00:00:00Pyramidal Cells11.304405976041036e-0012020-01-15T00:00:002020-01-15T00:00:00Cues11.279627823427695e-0012022-03-03T00:00:002022-03-03T00:00:00Thalamus11.228511194638053e-0012023-03-01T00:00:002023-03-01T00:00:00Microscopy, Fluorescence, Multiphoton11.217970869659813e-0012018-03-09T00:00:002018-03-09T00:00:00Wakefulness11.199039323462441e-0012023-03-01T00:00:002023-03-01T00:00:00Mice111.178629567370381e-0012018-03-09T00:00:002024-09-11T00:00:00Retinal Ganglion Cells11.143108609456102e-0012021-12-30T00:00:002021-12-30T00:00:00Calcium31.023569182928258e-0012020-01-15T00:00:002023-12-13T00:00:00Cerebral Cortex31.004259942121210e-0012022-03-03T00:00:002024-09-11T00:00:00gamma-Aminobutyric Acid19.955339332098498e-0022020-01-15T00:00:002020-01-15T00:00:00Animals129.701203759214286e-0022016-06-09T00:00:002024-09-11T00:00:00Epithelial Cells19.215627257676859e-0022024-11-20T00:00:002024-11-20T00:00:00Single-Cell Analysis19.035888499857207e-0022024-11-20T00:00:002024-11-20T00:00:00Transcriptome28.525519677382747e-0022022-11-15T00:00:002024-11-20T00:00:00Hippocampus18.391814312259470e-0022023-12-13T00:00:002023-12-13T00:00:00Nerve Net28.374171069453634e-0022020-02-11T00:00:002021-09-24T00:00:00Retina18.227735890188524e-0022021-12-30T00:00:002021-12-30T00:00:00Mice, Inbred C57BL27.144843481484023e-0022024-04-19T00:00:002024-09-11T00:00:00Anxiety16.902983713133236e-0022024-04-19T00:00:002024-04-19T00:00:00Axons16.895402793823716e-0022016-06-09T00:00:002016-06-09T00:00:00Stress, Psychological16.734762137689615e-0022024-04-19T00:00:002024-04-19T00:00:00Data Curation15.482248095571651e-0022024-11-20T00:00:002024-11-20T00:00:00Imaging, Three-Dimensional15.310004755745117e-0022018-03-09T00:00:002018-03-09T00:00:00Software15.108505694464675e-0022018-03-09T00:00:002018-03-09T00:00:00Atlases as Topic14.807593323815267e-0022024-11-20T00:00:002024-11-20T00:00:00Computer Simulation14.761440200768256e-0022016-06-09T00:00:002016-06-09T00:00:00Thalamic Nuclei14.677474948738224e-0022023-03-01T00:00:002023-03-01T00:00:00Data Analysis14.665232701869325e-0022024-11-20T00:00:002024-11-20T00:00:00Cholinergic Agents14.664559143181245e-0022022-11-15T00:00:002022-11-15T00:00:00Choline O-Acetyltransferase14.621618135454723e-0022022-11-15T00:00:002022-11-15T00:00:00Locus Coeruleus14.374647842174226e-0022024-03-04T00:00:002024-03-04T00:00:00Optogenetics13.984880039996137e-0022024-04-19T00:00:002024-04-19T00:00:00Rats13.977577938638719e-0022016-06-09T00:00:002016-06-09T00:00:00Organ Specificity13.894256498780924e-0022024-11-20T00:00:002024-11-20T00:00:00Male43.736763424443933e-0022024-04-19T00:00:002025-05-02T00:00:00Fetal Development13.675357703401331e-0022024-11-20T00:00:002024-11-20T00:00:00Hypothalamus13.646181020189786e-0022024-04-19T00:00:002024-04-19T00:00:00Brain Stem13.551315147721944e-0022024-03-04T00:00:002024-03-04T00:00:00In Situ Hybridization, Fluorescence13.399479839016768e-0022024-03-04T00:00:002024-03-04T00:00:00Sensory Receptor Cells13.292406135178814e-0022022-11-15T00:00:002022-11-15T00:00:00Perception13.086852921322131e-0022023-03-01T00:00:002023-03-01T00:00:00Cell Lineage12.897337565326779e-0022024-11-20T00:00:002024-11-20T00:00:00Signal-To-Noise Ratio12.658634267022095e-0022018-03-09T00:00:002018-03-09T00:00:00Neuronal Plasticity12.464545793255964e-0022022-06-01T00:00:002022-06-01T00:00:00CD4-Positive T-Lymphocytes12.276522769221042e-0022024-11-20T00:00:002024-11-20T00:00:00Adaptor Proteins, Signal Transducing12.266327562260241e-0022022-11-15T00:00:002022-11-15T00:00:00CD8-Positive T-Lymphocytes12.060723571045964e-0022024-11-20T00:00:002024-11-20T00:00:00Cytokines11.925042566048448e-0022024-11-20T00:00:002024-11-20T00:00:00Computational Biology11.888682014275048e-0022021-12-30T00:00:002021-12-30T00:00:00Female21.792785084477330e-0022024-04-19T00:00:002025-05-02T00:00:00Sleep11.577700691292465e-0022023-03-01T00:00:002023-03-01T00:00:00Humans31.489993077835881e-0022024-03-04T00:00:002025-05-02T00:00:00Infant, Newborn11.320789580100697e-0022024-11-20T00:00:002024-11-20T00:00:00Brain21.176865422839391e-0022018-03-09T00:00:002021-09-24T00:00:00Depression11.119776489512027e-0022022-06-01T00:00:002022-06-01T00:00:00