Director, Orthopaedic Research Laboratory, Brigham and Women's Hospital Director, Tissue Engineering Laboratory, VA Boston Healthcare System Senior Lecturer, Mechanical Engineering , MIT Prof. Spector has been engaged in biomaterials research for over 30 years, and in tissue engineering studies for 15 years, employing animal models and cell culture systems. He is supervising investigations related to musculoskeletal and nerve regeneration, involving biopolymer sponge-like scaffolds and injectable gels. He recently has established projects demonstrating the potential of extracorporeal shock wave treatment to enhance the make-up of select tissues to be used as autografts for bone and cartilage repair. Prof. Spector teaches 4 subjects at MIT: Biomaterial-Tissue Interactions (2.79J/3.96J/BEH.441HST 522J); Cell-Matrix Mechanics (2.785J/3.97J/20.411J/HST523J); Design of Medical Devices/Implants (2.782J/3.961J/20.451J/HST524J); and Principles and Practice of Tissue Engineering (HST.535). He is the principal research supervisor for students in: MIT doctoral programs; Harvard Medical School; and postgraduate programs at the Harvard School of Dental Medicine. His postdoctoral research fellows come with varied backgrounds from many countries. Dr. Spector is a VA Research Career Scientist. Other Positions: 2005-present: Co-Editor-in Chief, Biomedical Materials: Materials for Tissue Engineering & Regenerative Medicine 1993-1997: Chairman, Food and Drug Administration General and Plastic Surgery Devices Advisory Panel 1990-1991: President, Society for Biomaterials
Professor of Orthopedic Surgery (Biomaterials), Emeritus
Orr TE, Villars PA, Mitchell SL, Hsu HP, Spector M
Compressive properties of cancellous bone defects in a rabbit model treated with particles of natural bone mineral and synthetic hydroxyapatite. Biomaterials. 2001 Jul; 22(14):1953-9.
Compressive properties of cancellous bone defects in a rabbit model treated with particles of natural bone mineral and synthetic hydroxyapatite.
Spilker MH, Yannas IV, Kostyk SK, Norregaard TV, Hsu HP, Spector M
The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord. Restor Neurol Neurosci. 2001; 18(1):23-38.
The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord.
Biomedical materials to meet the challenges of the aging epidemic. Biomed Mater. 2018 03 16; 13(3):030201.
Biomedical materials to meet the challenges of the aging epidemic.
Hemopoiesis in demineralized bone allografts. Exp Hematol. 1980 Jul; 8(6):763-9.
Hemopoiesis in demineralized bone allografts.
Wu H-C, Wang T-W, Bohn MC, Lin F-H, and Spector M.
Novel magnetic hydroxyapatite nanoparticles as non-viral vectors for the glial cell line-derived neurotrophic factor gene
Advanced Functional Materials. Novel magnetic hydroxyapatite nanoparticles as non-viral vectors for the glial cell line-derived neurotrophic factor gene. 2009; 19:1-11.
Clinical orthopaedics and related research
Radionuclide bone imaging of femoral prostheses with porous coatings. Clin Orthop Relat Res. 1981 Oct; (160):242-9.
Radionuclide bone imaging of femoral prostheses with porous coatings.
Tucker BE, Cottell CM, Auyeung RC, Spector M, Nancollas GH
Pre-conditioning and dual constant composition dissolution kinetics of pulsed laser deposited hydroxyapatite thin films on silicon substrates. Biomaterials. 1996 Mar; 17(6):631-7.
Pre-conditioning and dual constant composition dissolution kinetics of pulsed laser deposited hydroxyapatite thin films on silicon substrates.
Lucas RL, Lostroh CP, DiRusso CC, Spector MP, Wanner BL, Lee CA
Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar typhimurium. J Bacteriol. 2000 Apr; 182(7):1872-82.
Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar typhimurium.
Biomaterial failure. Orthop Clin North Am. 1992 Apr; 23(2):211-7.
Funakoshi T, Schmid T, Hsu HP, Spector M
The Journal of bone and joint surgery. American volume
Lubricin distribution in the goat infraspinatus tendon: a basis for interfascicular lubrication. J Bone Joint Surg Am. 2008 Apr; 90(4):803-14.
Lubricin distribution in the goat infraspinatus tendon: a basis for interfascicular lubrication.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The presence and distribution of lubricin in the caprine intervertebral disc. J Orthop Res. 2008 Oct; 26(10):1398-406.
The presence and distribution of lubricin in the caprine intervertebral disc.
Novel cell-scaffold interactions encountered in tissue engineering: contractile behavior of musculoskeletal connective tissue cells. Tissue Eng. 2002 Jul; 8(3):351-7.
Novel cell-scaffold interactions encountered in tissue engineering: contractile behavior of musculoskeletal connective tissue cells.
Sun XD, Jeng L, Bolliet C, Olsen BR, Spector M
Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials. 2009 Feb; 30(6):1222-31.
Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds.
Pascher A, Palmer GD, Steinert A, Oligino T, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC
Gene delivery to cartilage defects using coagulated bone marrow aspirate. Gene Ther. 2004 Jan; 11(2):133-41.
Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Noordin S, Shortkroff S, Sledge CB, Spector M
Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates. Biomaterials. 2004 Oct; 25(23):5347-52.
Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates.
Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells. J Orthop Res. 2010 Jun; 28(6):716-25.
Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells.
Kearney CJ, Lee JY, Padera RF, Hsu HP, Spector M
Extracorporeal shock wave-induced proliferation of periosteal cells. J Orthop Res. 2011 Oct; 29(10):1536-43.
Extracorporeal shock wave-induced proliferation of periosteal cells.
Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm. 2011 Aug 01; 8(4):994-1001.
Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage.
The International journal of periodontics & restorative dentistry
Effects of PDGF-BB and OP-1 on mesenchymal stem cells in a porous mineral block. Int J Periodontics Restorative Dent. 2013 Mar-Apr; 33(2):e72-8.
Effects of PDGF-BB and OP-1 on mesenchymal stem cells in a porous mineral block.
Cao X, Wang J, Deng W, Chen J, Wang Y, Zhou J, Du P, Xu W, Wang Q, Wang Q, Yu Q, Spector M, Yu J, Xu X
Photoluminescent Cationic Carbon Dots as efficient Non-Viral Delivery of Plasmid SOX9 and Chondrogenesis of Fibroblasts. Sci Rep. 2018 05 04; 8(1):7057.
Photoluminescent Cationic Carbon Dots as efficient Non-Viral Delivery of Plasmid SOX9 and Chondrogenesis of Fibroblasts.
Teichgraeber JF, Spector M, Per-Lee JH, Jackson RT
Tissue response to Plasti-Pore and Proplast otologic implants in the middle ears of cats. Am J Otol. 1983 Oct; 5(2):127-36.
Tissue response to Plasti-Pore and Proplast otologic implants in the middle ears of cats.
Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. J Orthop Res. 2007 Jul; 25(7):873-83.
Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage.
Society for Biomaterials and Artificial Organs (India)
Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2007 Mar 02; 137 Suppl 155:157S-165S.
Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems.
Moskowitz JS, Blaisse MR, Samuel RE, Hsu HP, Harris MB, Martin SD, Lee JC, Spector M, Hammond PT
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model. Biomaterials. 2010 Aug; 31(23):6019-30.
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.
Synovium tissue engineering to prevent tendon sheath adhesion. Plast Reconstr Surg. 2010 Jul; 126(1):44e-45e.
Synovium tissue engineering to prevent tendon sheath adhesion.
Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. Biomaterials. 2012 May; 33(15):3835-45.
Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment.
Macaya DJ, Hayakawa K, Arai K, Spector M
Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602.
Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury.
Harley BA, Spilker MH, Wu JW, Asano K, Hsu HP, Spector M, Yannas IV
Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cells Tissues Organs. 2004; 176(1-3):153-65.
Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps.
Hastreiter D, Chao J, Wang Q, Ozuna RM, Spector M
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Alpha-smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitro. Wound Repair Regen. 2004 Jul-Aug; 12(4):430-8.
Alpha-smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitro.
Journal of biomedical materials research. Part A
Effects of collagen type on the behavior of adult canine annulus fibrosus cells in collagen-glycosaminoglycan scaffolds. J Biomed Mater Res A. 2004 Nov 01; 71(2):233-41.
Effects of collagen type on the behavior of adult canine annulus fibrosus cells in collagen-glycosaminoglycan scaffolds.
The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials. 2001 Sep; 22(17):2393-402.
The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro.
Regulation of NAD biosynthesis in Salmonella typhimurium: expression of nad-lac gene fusions and identification of a nad regulatory locus. J Gen Microbiol. 1985 Oct; 131(10):2759-70.
Regulation of NAD biosynthesis in Salmonella typhimurium: expression of nad-lac gene fusions and identification of a nad regulatory locus.
Wang H, Gerbaudo VH, Hobbs LW, Spector M
Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro. Bone. 2005 Jan; 36(1):84-92.
Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro.
Hirshorn MS, Holley LK, Hales JR, Money DK, Young FA, Spector M, Wickham GG
Pacing and clinical electrophysiology : PACE
Screening of solid and porous materials for pacemaker electrodes. Pacing Clin Electrophysiol. 1981 Jul; 4(4):380-90.
Screening of solid and porous materials for pacemaker electrodes.
Spector M, Michno MJ, Smarook WH, Kwiatkowski GT
Journal of biomedical materials research
A high-modulus polymer for porous orthopedic implants: biomechanical compatibility of porous implants. J Biomed Mater Res. 1978 Sep; 12(5):665-77.
A high-modulus polymer for porous orthopedic implants: biomechanical compatibility of porous implants.
Faryniarz DA, Chaponnier C, Gabbiani G, Yannas IV, Spector M
Myofibroblasts in the healing lapine medial collateral ligament: possible mechanisms of contraction. J Orthop Res. 1996 Mar; 14(2):228-37.
Myofibroblasts in the healing lapine medial collateral ligament: possible mechanisms of contraction.
Effects of magnesium deficiency on intratubular calcium oxalate formation and crystalluria in hyperoxaluric rats. J Urol. 1982 Mar; 127(3):598-604.
Effects of magnesium deficiency on intratubular calcium oxalate formation and crystalluria in hyperoxaluric rats.
Pore strain behaviour of collagen-glycosaminoglycan analogues of extracellular matrix. Biomaterials. 1995 Jul; 16(10):777-83.
Pore strain behaviour of collagen-glycosaminoglycan analogues of extracellular matrix.
Development of hyaluronic acid-based scaffolds for brain tissue engineering. Acta Biomater. 2009 Sep; 5(7):2371-84.
Development of hyaluronic acid-based scaffolds for brain tissue engineering.
Lubricin distribution in the human intervertebral disc. J Bone Joint Surg Am. 2009 Sep; 91(9):2205-12.
Lubricin distribution in the human intervertebral disc.
Cross-linking affects cellular condensation and chondrogenesis in type II collagen-GAG scaffolds seeded with bone marrow-derived mesenchymal stem cells. J Orthop Res. 2010 Sep; 28(9):1184-92.
Cross-linking affects cellular condensation and chondrogenesis in type II collagen-GAG scaffolds seeded with bone marrow-derived mesenchymal stem cells.
The people behind the papers, and how much data is enough? Biomed Mater. 2012 Dec 1; 7(6):060201-60201.
The people behind the papers, and how much data is enough?
Roberson JR, Spector M, Baggett MA, Kita K
Porous-coated femoral components in a canine model for revision arthroplasty. J Bone Joint Surg Am. 1988 Sep; 70(8):1201-8.
Porous-coated femoral components in a canine model for revision arthroplasty.
Quantitative characterization of cells at the interface of long-term implants of selected polymers. J Biomed Mater Res. 1986 May-Jun; 20(5):653-66.
Quantitative characterization of cells at the interface of long-term implants of selected polymers.
Osteoinduction within porous polysulfone implants at extraosseous sites using demineralized allogeneic bone matrix. J Biomed Mater Res. 1983 Sep; 17(5):793-806.
Osteoinduction within porous polysulfone implants at extraosseous sites using demineralized allogeneic bone matrix.
Shortkroff S, Barone L, Hsu HP, Wrenn C, Gagne T, Chi T, Breinan H, Minas T, Sledge CB, Tubo R, Spector M
Healing of chondral and osteochondral defects in a canine model: the role of cultured chondrocytes in regeneration of articular cartilage. Biomaterials. 1996 Jan; 17(2):147-54.
Healing of chondral and osteochondral defects in a canine model: the role of cultured chondrocytes in regeneration of articular cartilage.
Lim TC, Rokkappanavar S, Toh WS, Wang LS, Kurisawa M, Spector M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1a release and compatible structural support. FASEB J. 2013 Mar; 27(3):1023-33.
Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1a release and compatible structural support.
Rushton HG, Spector M, Rodgers AL, Hughson M, Magura CE
Developmental aspects of calcium oxalate tubular deposits and calculi induced in rat kidneys. Invest Urol. 1981 Jul; 19(1):52-7.
Developmental aspects of calcium oxalate tubular deposits and calculi induced in rat kidneys.
Porter AE, Taak P, Hobbs LW, Coathup MJ, Blunn GW, Spector M
Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy. Biomaterials. 2004 Sep; 25(21):5199-208.
Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy.
Calcification of axons in experimental spinal cord trauma. Ann Neurol. 1977 Dec; 2(6):520-3.
Calcification of axons in experimental spinal cord trauma.
Hennis HL, Hennigar GR, Greene WB, Hilton CW, Spector M
Intratubular calcium phosphate deposition in acute analgesic nephropathy in rabbits. Am J Pathol. 1982 Mar; 106(3):356-63.
Intratubular calcium phosphate deposition in acute analgesic nephropathy in rabbits.
Funakoshi T, Martin SD, Wolf BT, Schmid TM, Thornhill TS, Spector M
alpha-Smooth muscle actin-expressing cells and lubricin in periprosthetic tissue. J Biomed Mater Res A. 2010 May; 93(2):515-27.
alpha-Smooth muscle actin-expressing cells and lubricin in periprosthetic tissue.
Zhang D, Cheriyan T, Martin SD, Gomoll AH, Schmid TM, Spector M
Lubricin distribution in the torn human anterior cruciate ligament and meniscus. J Orthop Res. 2011 Dec; 29(12):1916-22.
Lubricin distribution in the torn human anterior cruciate ligament and meniscus.
Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci. J Bacteriol. 1986 Sep; 167(3):1086-8.
Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci.
Histological investigation of bone induction by demineralized allogeneic bone matrix: a natural biomaterial for osseous reconstruction. J Biomed Mater Res. 1983 Nov; 17(6):1003-14.
Histological investigation of bone induction by demineralized allogeneic bone matrix: a natural biomaterial for osseous reconstruction.
Spector MP, DiRusso CC, Pallen MJ, Del Portillo FG, Dougan G, Finlay BB
The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locus. Microbiology (Reading). 1999 Jan; 145 ( Pt 1):15-31.
The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locus.
Mueller SM, Shortkroff S, Schneider TO, Breinan HA, Yannas IV, Spector M
Meniscus cells seeded in type I and type II collagen-GAG matrices in vitro. Biomaterials. 1999 Apr; 20(8):701-9.
Meniscus cells seeded in type I and type II collagen-GAG matrices in vitro.
Ma J, Tian W-M, Hou S-P, Xu Q-Y, Spector M, and Cui F-Z.
An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model
Biomed. Mater.: Mater. in Tissue Engr. and Regen. Med. An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. 2007; 2:233-240.
Biomed. Mater.: Mater. in Tissue Engr. and Regen. Med
Healing of defects in canine articular cartilage: distribution of nonvascular alpha-smooth muscle actin-containing cells. Wound Repair Regen. 2000 Mar-Apr; 8(2):145-58.
Healing of defects in canine articular cartilage: distribution of nonvascular alpha-smooth muscle actin-containing cells.
Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Eng. 2000 Oct; 6(5):555-65.
Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro.
Magura CE, Spector M, Allen R, Turner WR
Brushite encrustation and lithiasis of the prostatic bed after transurethral resection of the prostate. J Urol. 1980 Feb; 123(2):294-7.
Brushite encrustation and lithiasis of the prostatic bed after transurethral resection of the prostate.
Human stones. Endeavour. 1981; 5(3):119-26.
High resolution electron microscope study of lattice images in biological apatites. J Microsc. 1975 Jan; 103(1):55-62.
High resolution electron microscope study of lattice images in biological apatites.
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society
Scaffold-based articular cartilage repair. IEEE Eng Med Biol Mag. 2003 Sep-Oct; 22(5):42-50.
Scaffold-based articular cartilage repair.
Ramsay AW, Spector M, Rodgers AL, Miller RL, Knapp DR
Crystalluria following excretory urography. Br J Urol. 1982 Aug; 54(4):341-5.
Crystalluria following excretory urography.
Poss R, Walker P, Spector M, Reilly DT, Robertson DD, Sledge CB
Strategies for improving fixation of femoral components in total hip arthroplasty. Clin Orthop Relat Res. 1988 Oct; (235):181-94.
Strategies for improving fixation of femoral components in total hip arthroplasty.
Turner RT, Bell NH, Duvall P, Bobyn JD, Spector M, Holton EM, Baylink DJ
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Spaceflight results in formation of defective bone. Proc Soc Exp Biol Med. 1985 Dec; 180(3):544-9.
Spaceflight results in formation of defective bone.
Ion beam etching of red blood cells and latex spheres. Nature. 1974 Jan 04; 247(5435):61-2.
Ion beam etching of red blood cells and latex spheres.
Benz EB, Sherburne B, Hayek JE, Falchuk KH, Sledge CB, Spector M
Lymphadenopathy associated with total joint prostheses. A report of two cases and a review of the literature. J Bone Joint Surg Am. 1996 Apr; 78(4):588-93.
Lymphadenopathy associated with total joint prostheses. A report of two cases and a review of the literature.
Madaghiele M, Sannino A, Yannas IV, Spector M
Collagen-based matrices with axially oriented pores. J Biomed Mater Res A. 2008 Jun 01; 85(3):757-67.
Collagen-based matrices with axially oriented pores.
Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering. Biomed Mater. 2009 Aug; 4(4):045012.
Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering.
Grossner T, Gotterbarm T, Gerbaudo VH, Haberkorn U, Spector M
99mTc-Methyl-Diphosphonate Binding to Mineral Deposits in Cultures of Marrow-Derived Mesenchymal Stem Cells in Osteogenic Medium. Tissue Eng Part C Methods. 2019 01; 25(1):49-57.
99mTc-Methyl-Diphosphonate Binding to Mineral Deposits in Cultures of Marrow-Derived Mesenchymal Stem Cells in Osteogenic Medium.
The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation. Tissue Eng Part A. 2012 Jul; 18(13-14):1500-8.
The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation.
Cheriyan T, Guo L, Orgill DP, Padera RF, Schmid TM, Spector M
Journal of biomedical materials research. Part B, Applied biomaterials
Lubricin in human breast tissue expander capsules. J Biomed Mater Res B Appl Biomater. 2012 Oct; 100(7):1961-9.
Lubricin in human breast tissue expander capsules.
Spector M, Davis RJ, Lunceford EM, Harmon SL
Porous polysulfone coatings for fixation of femoral stems by bony ingrowth. Clin Orthop Relat Res. 1983 Jun; (176):34-41.
Porous polysulfone coatings for fixation of femoral stems by bony ingrowth.
Rushton HG, Spector M, Rodgers AL, Magura CE
Crystal deposition in the renal tubules of hyperoxaluric and hypomagnesemic rats. Scan Electron Microsc. 1980; (3):387-94, 398.
Crystal deposition in the renal tubules of hyperoxaluric and hypomagnesemic rats.
Robertson DD, Mintzer CM, Weissman BN, Ewald FC, LeBoff M, Spector M
Distal loss of femoral bone following total knee arthroplasty. Measurement with visual and computer-processing of roentgenograms and dual-energy x-ray absorptiometry. J Bone Joint Surg Am. 1994 Jan; 76(1):66-76.
Distal loss of femoral bone following total knee arthroplasty. Measurement with visual and computer-processing of roentgenograms and dual-energy x-ray absorptiometry.
Zaleskas JM, Kinner B, Freyman TM, Yannas IV, Gibson LJ, Spector M
Growth factor regulation of smooth muscle actin expression and contraction of human articular chondrocytes and meniscal cells in a collagen-GAG matrix. Exp Cell Res. 2001 Oct 15; 270(1):21-31.
Growth factor regulation of smooth muscle actin expression and contraction of human articular chondrocytes and meniscal cells in a collagen-GAG matrix.
The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty. Clin Orthop Relat Res. 2004 Dec; (429):17-32.
The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty.
Deng W, Shao F, He Q, Wang Q, Shi W, Yu Q, Cao X, Feng C, Bi S, Chen J, Ma P, Li Y, Gong A, Tong S, Yu J, Spector M, Xu X, Zhang Z
Advanced materials (Deerfield Beach, Fla.)
EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells. Adv Mater. 2019 Mar; 31(10):e1806861.
EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells.
Funakoshi T, Martin SD, Schmid TM, Spector M
Distribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot study. Clin Orthop Relat Res. 2010 Jun; 468(6):1588-99.
Distribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot study.
Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds. Tissue Eng Part A. 2010 Oct; 16(10):3011-21.
Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds.
Coping with copying and conflicts (of interest). Biomed Mater. 2012 Feb; 7(1):010201.
Coping with copying and conflicts (of interest).
Characterization of a bilateral penetrating brain injury in rats and evaluation of a collagen biomaterial for potential treatment. J Neurotrauma. 2012 Jul 20; 29(11):2086-102.
Characterization of a bilateral penetrating brain injury in rats and evaluation of a collagen biomaterial for potential treatment.
Cell response to collagen-calcium phosphate cement scaffolds investigated for nonviral gene delivery
J. Materials Sci. Mater. in Med. Cell response to collagen-calcium phosphate cement scaffolds investigated for nonviral gene delivery. 2011; 22:887-897.
Characteristics of tissue growth into Proplast and porous polyethylene implants in bone. J Biomed Mater Res. 1979 Sep; 13(5):677-92.
Characteristics of tissue growth into Proplast and porous polyethylene implants in bone.
Hirshorn MS, Holley LK, Money DK, Spector M, Young FA, Hales JR
Histological evaluation of porous titanium cardiac pacemaker electrode tips. J Biomed Mater Res. 1984 Jan; 18(1):47-60.
Histological evaluation of porous titanium cardiac pacemaker electrode tips.
Garvin AJ, Pratt-Thomas HR, Spector M, Spicer SS, Williamson HO
American journal of obstetrics and gynecology
Gonadoblastoma: histologic, ultrastructural, and histochemical observations in five cases. Am J Obstet Gynecol. 1976 Jun 15; 125(4):459-71.
Gonadoblastoma: histologic, ultrastructural, and histochemical observations in five cases.
An interview with Joyce Y Wong: ensuring all voices in biomaterials community are heard. Biomed Mater. 2019 03 27; 14(3):030201.
An interview with Joyce Y Wong: ensuring all voices in biomaterials community are heard.
Park J, Baranov P, Aydin A, Abdelgawad H, Singh D, Niu W, Kurisawa M, Spector M, Young MJ
In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation. Cell Transplant. 2019 05; 28(5):596-606.
In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation.
John Homans Professor of Surgery, Emeritus
Maurice Edmond Mueller Professor of Orthopedic Surgery, Emeritus
Catharina Ormandy Professor of Orthopedic Surgery
Professor of Orthopedic Surgery, and of Oral and Maxillofacial Surgery, Emerita
Professor of Orthopedic Surgery, Emeritus
Associate Professor of Orthopedic Surgery
Biomaterials for Stroke Therapy. Stroke. 2019 08; 50(8):2278-2284.
Professor of Developmental Biology and Hersey Professor of Cell Biology, Emeritus
Alshihri A, Kämmerer PW, Heimes D, Niu W, Alnassar T, Spector M
Extracorporeal Shock Wave Stimulates Angiogenesis and Collagen Production in Facial Soft Tissue. J Surg Res. 2020 01; 245:483-491.
Extracorporeal Shock Wave Stimulates Angiogenesis and Collagen Production in Facial Soft Tissue.
Lim TC, Mandeville E, Weng D, Wang LS, Kurisawa M, Leite-Morris K, Selim MH, Lo EH, Spector M
Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage. Transl Stroke Res. 2020 06; 11(3):412-417.
Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage.
Chan SJ, Niu W, Hayakawa K, Hamanaka G, Wang X, Cheah PS, Guo S, Yu Z, Arai K, Selim MH, Kurisawa M, Spector M, Lo EH
Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem Cells Transl Med. 2019 12; 8(12):1242-1248.
Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels.
Rajappa R, Nazal MR, Stelzer JW, Hsu HP, Conaway WK, Rokkappanavar S, Niu W, Upadhyaya S, Alpaugh K, Spector M, Martin SD
Translational relevance of the goat as a preclinical model of the human labrum and chondrolabral junction-histological study. J Orthop Res. 2020 05; 38(5):1070-1080.
Translational relevance of the goat as a preclinical model of the human labrum and chondrolabral junction-histological study.
An interview with Jianwu Dai: understanding the biological processes underlying regeneration to direct the implementation of biomedical materials. Biomed Mater. 2020 05 07; 15(3):030201.
An interview with Jianwu Dai: understanding the biological processes underlying regeneration to direct the implementation of biomedical materials.
Chen J, Wang Q, Zhou J, Deng W, Yu Q, Cao X, Wang J, Shao F, Li Y, Ma P, Spector M, Yu J, Xu X
Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells. Nanoscale. 2017 Aug 03; 9(30):10820-10831.
Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells.
Alshihri A, Niu W, Kämmerer PW, Al-Askar M, Yamashita A, Kurisawa M, Spector M
Journal of tissue engineering and regenerative medicine
The effects of shock wave stimulation of mesenchymal stem cells on proliferation, migration, and differentiation in an injectable gelatin matrix for osteogenic regeneration. J Tissue Eng Regen Med. 2020 11; 14(11):1630-1640.
The effects of shock wave stimulation of mesenchymal stem cells on proliferation, migration, and differentiation in an injectable gelatin matrix for osteogenic regeneration.
Dromel PC, Singh D, Christoff-Tempesta T, Martheswaran T, Alexander-Katz A, Spector M, Young M
Controlling Growth Factor Diffusion by Modulating Water Content in Injectable Hydrogels. Tissue Eng Part A. 2021 06; 27(11-12):714-723.
Controlling Growth Factor Diffusion by Modulating Water Content in Injectable Hydrogels.
An interview with Roland (Roli) Peter Jakob, M.D.: biomaterials for orthoregeneration. Biomed Mater. 2020 12 23; 16(1):010201.
An interview with Roland (Roli) Peter Jakob, M.D.: biomaterials for orthoregeneration.
Niu W, Lim TC, Alshihri A, Rajappa R, Wang L, Kurisawa M, Spector M
Platelet-Derived Growth Factor Stimulated Migration of Bone Marrow Mesenchymal Stem Cells into an Injectable Gelatin-Hydroxyphenyl Propionic Acid Matrix. Biomedicines. 2021 Feb 17; 9(2).
Platelet-Derived Growth Factor Stimulated Migration of Bone Marrow Mesenchymal Stem Cells into an Injectable Gelatin-Hydroxyphenyl Propionic Acid Matrix.
Love CJ, Kirschenbaum D, Selim M, Lo EH, Rushing E, Spector M, Aguzzi A
Observation of Collagen-Containing Lesions After Hematoma Resolution in Intracerebral Hemorrhage. Stroke. 2021 05; 52(5):1856-1860.
Observation of Collagen-Containing Lesions After Hematoma Resolution in Intracerebral Hemorrhage.
Du D, Liu Z, Niu W, Weng D, Lim TC, Kurisawa M, Spector M
An Injectable Multifunctional Dual-Phase Bead-Reinforced Gelatin Matrix Permissive of Mesenchymal Stem Cell Infiltration for Musculoskeletal Soft Tissue Repair. Adv Healthc Mater. 2021 09; 10(18):e2100626.
An Injectable Multifunctional Dual-Phase Bead-Reinforced Gelatin Matrix Permissive of Mesenchymal Stem Cell Infiltration for Musculoskeletal Soft Tissue Repair.
Dromel PC, Singh D, Andres E, Likes M, Kurisawa M, Alexander-Katz A, Spector M, Young M
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy. NPJ Regen Med. 2021 Dec 20; 6(1):85.
A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy.
Nadra M, Niu W, Kurisawa M, Rousson D, Spector M
Platelet-Rich Plasma Lysate-Incorporating Gelatin Hydrogel as a Scaffold for Bone Reconstruction. Bioengineering (Basel). 2022 Sep 29; 9(10).
Platelet-Rich Plasma Lysate-Incorporating Gelatin Hydrogel as a Scaffold for Bone Reconstruction.
Dromel PC, Singh D, Alexander-Katz A, Kurisawa M, Spector M, Young M
Mechano-Chemical Effect of Gelatin- and HA-Based Hydrogels on Human Retinal Progenitor Cells. Gels. 2023 Jan 11; 9(1).
Mechano-Chemical Effect of Gelatin- and HA-Based Hydrogels on Human Retinal Progenitor Cells.
Associate Professor of Orthopedic Surgery, Part-time
Shah NJ, Hyder MN, Moskowitz JS, Quadir MA, Morton SW, Seeherman HJ, Padera RF, Spector M, Hammond PT
Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings. Sci Transl Med. 2013 Jun 26; 5(191):191ra83.
Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings.
Toh WS, Foldager CB, Olsen BR, Spector M
Basement membrane molecule expression attendant to chondrogenesis by nucleus pulposus cells and mesenchymal stem cells. J Orthop Res. 2013 Jul; 31(7):1136-43.
Basement membrane molecule expression attendant to chondrogenesis by nucleus pulposus cells and mesenchymal stem cells.
An interview with I V Yannas. Tracing one of the deepest roots of biomaterials in tissue engineering/regenerative medicine. Interview by Myron Spector. Biomed Mater. 2013 Aug; 8(4):040401.
An interview with I V Yannas. Tracing one of the deepest roots of biomaterials in tissue engineering/regenerative medicine. Interview by Myron Spector.
Spector BM, Ries MD, Bourne RB, Sauer WS, Long M, Hunter G
Wear performance of ultra-high molecular weight polyethylene on oxidized zirconium total knee femoral components. J Bone Joint Surg Am. 2001; 83-A Suppl 2 Pt 2:80-6.
Wear performance of ultra-high molecular weight polyethylene on oxidized zirconium total knee femoral components.
Tissue-engineered cartilaginous constructs for the treatment of caprine cartilage defects, including distribution of laminin and type IV collagen. Tissue Eng Part A. 2013 Oct; 19(19-20):2267-74.
Tissue-engineered cartilaginous constructs for the treatment of caprine cartilage defects, including distribution of laminin and type IV collagen.
'What led you to do that?' And other questions for the leaders of our field: the BMM Interview. Biomed Mater. 2013 Aug; 8(4):040201.
'What led you to do that?' And other questions for the leaders of our field: the BMM Interview.
Biomedical materials and 2013. Biomed Mater. 2013 Apr; 8(2):020201.
An interview with Molly S Shoichet. Developing biomaterials and mobilizing resources for assaults on some of the most devastating medical problems by Myron Spector. Biomed Mater. 2013 Dec; 8(6):060401.
An interview with Molly S Shoichet. Developing biomaterials and mobilizing resources for assaults on some of the most devastating medical problems by Myron Spector.
The tissue engineer's toolbox manifesto. Biomed Mater. 2014 Feb; 9(1):010201.
The tissue engineer's toolbox manifesto.
An interview with Jackie Yi-Ru Ying: the compleat multi-tasker. Biomed Mater. 2014 Jun; 9(3):030401.
An interview with Jackie Yi-Ru Ying: the compleat multi-tasker.
Zhou J, Deng W, Wang Y, Cao X, Chen J, Wang Q, Xu W, Du P, Yu Q, Chen J, Spector M, Yu J, Xu X
Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake. Acta Biomater. 2016 09 15; 42:209-219.
Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake.
Shah NJ, Hyder MN, Quadir MA, Dorval Courchesne NM, Seeherman HJ, Nevins M, Spector M, Hammond PT
Proceedings of the National Academy of Sciences of the United States of America
Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12847-52.
Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction.
The CEO as a medical device 'translator': a remembrance of Peter Geistlich, PhD. Biomed Mater. 2014 Sep 27; 9(5):050401.
The CEO as a medical device 'translator': a remembrance of Peter Geistlich, PhD.
Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor. J Tissue Eng Regen Med. 2015 Feb; 9(2):137-50.
Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor.
Foldager CB, Nyengaard JR, Lind M, Spector M
A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue. Cartilage. 2015 Apr; 6(2):123-32.
A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue.
Foldager CB, Gomoll AH, Lind M, Spector M
Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair. Cartilage. 2012 Apr; 3(2):108-17.
Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair.
Johnson LL, Delano M, Spector M, Pittsley A, Gottschalk A
The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up. Cartilage. 2014 Apr; 5(2):86-96.
The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up.
Zhang D, Cheriyan T, Martin SD, Schmid TM, Spector M
Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints. Cartilage. 2012 Apr; 3(2):165-72.
Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints.
Johnson LL, DeLano MC, Spector M, Jeng L, Pittsley A, Gottschalk A
The Biological Response following Autogenous Bone Grafting for Large-Volume Defects of the Knee: Index Surgery through 12 to 21 Years' Follow-up. Cartilage. 2012 Jan; 3(1):86-99.
The Biological Response following Autogenous Bone Grafting for Large-Volume Defects of the Knee: Index Surgery through 12 to 21 Years' Follow-up.
Foldager CB, Toh WS, Gomoll AH, Olsen BR, Spector M
Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues. Cartilage. 2014 Apr; 5(2):123-32.
Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues.
An auspicious decade for biomedical materials. Biomed Mater. 2015 Dec 23; 11(1):010201.
An auspicious decade for biomedical materials.
The Role of Lubricin in the Impaired Healing of Ruptured Ligaments and in the Therapeutic Treatment of Ligaments with Extracorporeal Shock Waves
Contractile Behavior of Human Periodontal Ligament Fibroblasts in Collagen Matrices in vitro
Foldager CB, Toh WS, Christensen BB, Lind M, Gomoll AH, Spector M
Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects. Cartilage. 2016 Jan; 7(1):52-61.
Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects.
Injectable biomaterials: a perspective on the next wave of injectable therapeutics. Biomed Mater. 2016 Feb 02; 11(1):014110.
Injectable biomaterials: a perspective on the next wave of injectable therapeutics.
Regulation of Contractile Behavior of Fibroblasts in Inured Rotator Cuffs and Huypertrophic Scars
Tissue Engineering and Stem Cell Research
The Identificaiton of Myofibroblast in Oral Lesions
Contraction and Shrinkage of Collagen Matrices by Exogenous Cells from Ligament Extract
Decellularized tissues and organs: an historical perspective and prospects for the future. Biomed Mater. 2016 Mar 17; 11(2):020201.
Decellularized tissues and organs: an historical perspective and prospects for the future.
Non-Viral Transfection of Caprine Mesenchymal Stem Cells with BMP-7 Plasmid: Effects of Plasmid Size and Type of Medium
The living legacy of a biomaterials founder: remembering Samuel F Hulbert, PhD. Biomed Mater. 2016 Mar 22; 11(2):020202.
The living legacy of a biomaterials founder: remembering Samuel F Hulbert, PhD.
Min J, Choi KY, Dreaden EC, Padera RF, Braatz RD, Spector M, Hammond PT
Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair. ACS Nano. 2016 04 26; 10(4):4441-50.
Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair.
Mesenchymal stem cells on Type II collagen/GAG scaffolds for cartilage regeneration
POROUS POLYETHYLENE AND POROUS POLYSULFONE TOOTH ROOTS
CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES
An interview with Arthur J Coury: an extensively experienced perspective on medical device development. Biomed Mater. 2016 10 06; 11(5):050401.
An interview with Arthur J Coury: an extensively experienced perspective on medical device development.
Toh WS, Foldager CB, Hui JH, Olsen BR, Spector M
Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules. Curr Stem Cell Res Ther. 2016; 11(8):618-625.
Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules.
American Academy of Orthopaedic Surgeons/Orthopaedic Research Society
Elizabeth Winston-Lanier Kappa Delta Award
Clemson Award for Applied Biomaterials Research
Porous titanium tooth roots: clinical evaluation. J Prosthet Dent. 1979 May; 41(5):561-5.
Porous titanium tooth roots: clinical evaluation.
Nehrer S, Breinan HA, Ramappa A, Shortkroff S, Young G, Minas T, Sledge CB, Yannas IV, Spector M
Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. J Biomed Mater Res. 1997; 38(2):95-104.
Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro.
Spector M, Shortkroff S, Hsu HP, Taylor-Zapatka S, Lane N, Sledge CB, Thornhill TS
Synovium-like tissue from loose joint replacement prosthesis: comparison of human material with a canine model. Semin Arthritis Rheum. 1992 Apr; 21(5):335-44.
Synovium-like tissue from loose joint replacement prosthesis: comparison of human material with a canine model.
Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. J Biomed Mater Res A. 2003 Mar 01; 64(3):560-9.
Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression.
Tribological evaluation of oxidized zirconium using an articular cartilage counterface: a novel material for potential use in hemiarthroplasty. Biomaterials. 1997 Mar; 18(5):441-7.
Tribological evaluation of oxidized zirconium using an articular cartilage counterface: a novel material for potential use in hemiarthroplasty.
Spector MP, Garcia Del Portillo F, Bearson SMD, Mahmud A, Magut M, Finlay BB, Dougan G, Foster JW, Pallen MJ
The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium. Microbiology (Reading). 1999 Nov; 145 ( Pt 11):3035-3045.
The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium.
Lapine and canine bone marrow stromal cells contain smooth muscle actin and contract a collagen-glycosaminoglycan matrix. Tissue Eng. 2001 Dec; 7(6):829-41.
Lapine and canine bone marrow stromal cells contain smooth muscle actin and contract a collagen-glycosaminoglycan matrix.
Meaney Murray M, Rice K, Wright RJ, Spector M
The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res. 2003 Mar; 21(2):238-44.
The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold.
Biomaterials for Enhancing CNS Repair. Transl Stroke Res. 2017 02; 8(1):57-64.
Toh WS, Brittberg M, Farr J, Foldager CB, Gomoll AH, Hui JH, Richardson JB, Roberts S, Spector M
Cellular senescence in aging and osteoarthritis. Acta Orthop. 2016 Dec; 87(sup363):6-14.
Cellular senescence in aging and osteoarthritis.
Comu AA, Shortkroff S, Zhang X, Spector M
Association of fibroblast orientation around titanium in vitro with expression of a muscle actin. Biomaterials. 2000 Sep; 21(18):1887-96.
Association of fibroblast orientation around titanium in vitro with expression of a muscle actin.
Spector MS, Heiney PA, Naciri J, Weslowski BT, Holt DB, Shashidhar R
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Electroclinic liquid crystals with large induced tilt angle and small layer contraction Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Feb; 61(2):1579-84.
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics
Electroclinic liquid crystals with large induced tilt angle and small layer contraction
Foldager CB, Bendtsen M, Berg LC, Brinchmann JE, Brittberg M, Bunger C, Canseco J, Chen L, Christensen BB, Colombier P, Deleuran BW, Edwards J, Elmengaard B, Farr J, Gatenholm B, Gomoll AH, Hui JH, Jakobsen RB, Joergensen NL, Kassem M, Koch T, Kold S, Krogsgaard MR, Lauridsen H, Le D, Le Visage C, Lind M, Nygaard JV, Olesen ML, Pedersen M, Rathcke M, Richardson JB, Roberts S, Rölfing JH, Sakai D, Toh WS, Urban J, Spector M
Aarhus Regenerative Orthopaedics Symposium (AROS). Acta Orthop. 2016 Dec; 87(sup363):1-5.
Aarhus Regenerative Orthopaedics Symposium (AROS).
The starvation-stress response (SSR) of Salmonella. Adv Microb Physiol. 1998; 40:233-79.
The starvation-stress response (SSR) of Salmonella.
Breinan HA, Minas T, Hsu HP, Nehrer S, Sledge CB, Spector M
Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg Am. 1997 Oct; 79(10):1439-51.
Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model.
Livingston BJ, Chmell MJ, Spector M, Poss R
Complications of total hip arthroplasty associated with the use of an acetabular component with a Hylamer liner. J Bone Joint Surg Am. 1997 Oct; 79(10):1529-38.
Complications of total hip arthroplasty associated with the use of an acetabular component with a Hylamer liner.
Nehrer S, Breinan HA, Ramappa A, Hsu HP, Minas T, Shortkroff S, Sledge CB, Yannas IV, Spector M
Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model. Biomaterials. 1998 Dec; 19(24):2313-28.
Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model.
Histologic analysis of tissue after failed cartilage repair procedures. Clin Orthop Relat Res. 1999 Aug; (365):149-62.
Histologic analysis of tissue after failed cartilage repair procedures.
Distribution of chondrocytes containing alpha-smooth muscle actin in human articular cartilage. J Orthop Res. 2000 Sep; 18(5):749-55.
Distribution of chondrocytes containing alpha-smooth muscle actin in human articular cartilage.
Musculoskeletal connective tissue cells with muscle: expression of muscle actin in and contraction of fibroblasts, chondrocytes, and osteoblasts. Wound Repair Regen. 2001 Jan-Feb; 9(1):11-8.
Musculoskeletal connective tissue cells with muscle: expression of muscle actin in and contraction of fibroblasts, chondrocytes, and osteoblasts.
Regional variations in certain cellular characteristics in human lumbar intervertebral discs, including the presence of alpha-smooth muscle actin. J Orthop Res. 2001 Jul; 19(4):597-604.
Regional variations in certain cellular characteristics in human lumbar intervertebral discs, including the presence of alpha-smooth muscle actin.
Comut AA, Weber HP, Shortkroff S, Cui FZ, Spector M
Connective tissue orientation around dental implants in a canine model. Clin Oral Implants Res. 2001 Oct; 12(5):433-40.
Connective tissue orientation around dental implants in a canine model.
Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase. Biomaterials. 2004 Feb; 25(3):473-82.
Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase.
Orr TE, Patel AM, Wong B, Hatzigiannis GP, Minas T, Spector M
Attachment of periosteal grafts to articular cartilage with fibrin sealant. J Biomed Mater Res. 1999 Mar 05; 44(3):308-13.
Attachment of periosteal grafts to articular cartilage with fibrin sealant.
Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M
Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res. 2000 Jun 01; 60(5):666-77.
Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap.
Torres DS, Freyman TM, Yannas IV, Spector M
Tendon cell contraction of collagen-GAG matrices in vitro: effect of cross-linking. Biomaterials. 2000 Aug; 21(15):1607-19.
Tendon cell contraction of collagen-GAG matrices in vitro: effect of cross-linking.
Breinan HA, Martin SD, Hsu HP, Spector M
Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes. J Orthop Res. 2000 Sep; 18(5):781-9.
Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes.
Wang H, Eliaz N, Xiang Z, Hsu HP, Spector M, Hobbs LW
Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy. Biomaterials. 2006 Aug; 27(23):4192-203.
Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy.
Chan SJ, Love C, Spector M, Cool SM, Nurcombe V, Lo EH
Endogenous regeneration: Engineering growth factors for stroke. Neurochem Int. 2017 Jul; 107:57-65.
Endogenous regeneration: Engineering growth factors for stroke.
Schneider TO, Mueller SM, Shortkroff S, Spector M
Expression of alpha-smooth muscle actin in canine intervertebral disc cells in situ and in collagen-glycosaminoglycan matrices in vitro. J Orthop Res. 1999 Mar; 17(2):192-9.
Expression of alpha-smooth muscle actin in canine intervertebral disc cells in situ and in collagen-glycosaminoglycan matrices in vitro.
Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M
Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Wound Repair Regen. 2000 Sep-Oct; 8(5):383-91.
Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin.
The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials. Biomaterials. 2002 Feb; 23(3):921-8.
The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials.
Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res. 2002 Aug 01; 278(1):72-83.
Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells.
Contractile actin expression in torn human menisci. Wound Repair Regen. 2002 Jul-Aug; 10(4):259-66.
Contractile actin expression in torn human menisci.
Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow properties. Biomaterials. 2004 Aug; 25(18):4433-45.
Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow properties.
Galante JO, Lemons J, Spector M, Wilson PD, Wright TM
The biologic effects of implant materials. J Orthop Res. 1991 Sep; 9(5):760-75.
The biologic effects of implant materials.
Lee CR, Grodzinsky AJ, Hsu HP, Martin SD, Spector M
Effects of harvest and selected cartilage repair procedures on the physical and biochemical properties of articular cartilage in the canine knee. J Orthop Res. 2000 Sep; 18(5):790-9.
Effects of harvest and selected cartilage repair procedures on the physical and biochemical properties of articular cartilage in the canine knee.
Chamberlain LJ, Yannas IV, Arrizabalaga A, Hsu HP, Norregaard TV, Spector M
Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response. Biomaterials. 1998 Aug; 19(15):1393-403.
Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response.
Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M
Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res. 2001 Jul; 19(4):659-64.
Distribution of smooth muscle actin-containing cells in the human meniscus.
Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M
Extracorporeal shockwave-induced expression of lubricin in tendons and septa. Cell Tissue Res. 2011 Nov; 346(2):255-62.
Extracorporeal shockwave-induced expression of lubricin in tendons and septa.
Palmer G, Pascher A, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC
Critical reviews in eukaryotic gene expression
Development of gene-based therapies for cartilage repair. Crit Rev Eukaryot Gene Expr. 2002; 12(4):259-73.
Development of gene-based therapies for cartilage repair.
Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles. J Biomed Mater Res A. 2008 Jan; 84(1):73-83.
Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles.
Alpha-smooth-muscle actin in and contraction of porcine dental pulp cells. J Dent Res. 2002 Mar; 81(3):203-8.
Alpha-smooth-muscle actin in and contraction of porcine dental pulp cells.
Smooth muscle actin expression by human articular chondrocytes and their contraction of a collagen-glycosaminoglycan matrix in vitro. J Orthop Res. 2001 Mar; 19(2):233-41.
Smooth muscle actin expression by human articular chondrocytes and their contraction of a collagen-glycosaminoglycan matrix in vitro.
Porter AE, Hobbs LW, Rosen VB, Spector M
The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding. Biomaterials. 2002 Feb; 23(3):725-33.
The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding.
Gordon TD, Schloesser L, Humphries DE, Spector M
Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro. Tissue Eng. 2004 Jul-Aug; 10(7-8):1287-95.
Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro.
Ries MD, Bellare A, Livingston BJ, Cohen RE, Spector M
Early delamination of a Hylamer-M tibial insert. J Arthroplasty. 1996 Dec; 11(8):974-6.
Early delamination of a Hylamer-M tibial insert.
The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis. Biomaterials. 2001 Dec; 22(23):3145-54.
The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis.
Expression of smooth muscle actin in osteoblasts in human bone. J Orthop Res. 2002 May; 20(3):622-32.
Expression of smooth muscle actin in osteoblasts in human bone.
Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesis. Biomed Mater. 2007 Sep; 2(3):S135-41.
Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesis.
Kinner B, Gerstenfeld LC, Einhorn TA, Spector M
Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model. Bone. 2002 May; 30(5):738-45.
Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model.
Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold. Tissue Eng Part C Methods. 2008 Sep; 14(3):207-19.
Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold.
Growth of porcine enamel-, dentin-, and cementum-derived cells in collagen-glycosaminoglycan matrices in vitro: expression of alpha-smooth muscle actin and contraction. Tissue Eng. 2003 Feb; 9(1):175-86.
Growth of porcine enamel-, dentin-, and cementum-derived cells in collagen-glycosaminoglycan matrices in vitro: expression of alpha-smooth muscle actin and contraction.
Spilker MH, Asano K, Yannas IV, Spector M
Contraction of collagen-glycosaminoglycan matrices by peripheral nerve cells in vitro. Biomaterials. 2001 May; 22(10):1085-93.
Contraction of collagen-glycosaminoglycan matrices by peripheral nerve cells in vitro.
Chondral defects in animal models: effects of selected repair procedures in canines. Clin Orthop Relat Res. 2001 Oct; (391 Suppl):S219-30.
Chondral defects in animal models: effects of selected repair procedures in canines.
Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2006 May 13; 136(19-20):293-301.
Zhang Z, Li Z, Deng W, He Q, Wang Q, Shi W, Chen Q, Yang W, Spector M, Gong A, Yu J, Xu X
Biochemical and biophysical research communications
Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochem Biophys Res Commun. 2016 11 25; 480(4):727-733.
Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells.
Thornhill TS, Ozuna RM, Shortkroff S, Keller K, Sledge CB, Spector M
Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model. Biomaterials. 1990 Jul; 11:69-72.
Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model.
Hunziker E, Spector M, Libera J, Gertzman A, Woo SL, Ratcliffe A, Lysaght M, Coury A, Kaplan D, Vunjak-Novakovic G
Translation from research to applications. Tissue Eng. 2006 Dec; 12(12):3341-64.
Translation from research to applications.
Frank E, Evans R, Lee C, Treppo S, Spector M, Grodzinsky A
Quantitative electrical impedance analysis of cartilage degradation. Biorheology. 2004; 41(3-4):195-202.
Quantitative electrical impedance analysis of cartilage degradation.
Benz EB, Federman M, Godleski JJ, Bierbaum BE, Thornhill TS, Spector M
Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response. Biomaterials. 2001 Nov; 22(21):2835-42.
Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response.
Mazzucco D, McKinley G, Scott RD, Spector M
Rheology of joint fluid in total knee arthroplasty patients. J Orthop Res. 2002 Nov; 20(6):1157-63.
Rheology of joint fluid in total knee arthroplasty patients.
Pfeiffer E, Vickers SM, Frank E, Grodzinsky AJ, and Spector M.
The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds
Osteoarth. and Cart. The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds. 2008; 16:1237-1244.
Johnson LJ, Verioti C, Gelber C, Spector M, and D’Lima D.
The pathology of the end stage osteoarthritic lesion of the knee: Potential role in cartilage repair
The Knee. The pathology of the end stage osteoarthritic lesion of the knee: Potential role in cartilage repair. 2011; 18:402-6.
Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K
A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 07 15; 26(14):1078-1085.
A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells.
Spector M, Krokosky EM, Sax M, Pletcher J
Atherosclerotic plaque: x-ray diffraction investigation. Science. 1969 Aug 15; 165(3894):711.
Atherosclerotic plaque: x-ray diffraction investigation.
Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes. J Biomed Mater Res A. 2008 Mar 15; 84(4):1038-48.
Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes.
Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels. Acta Biomater. 2012 Jul; 8(6):2203-12.
Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels.
Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res. 1999 Jan; 17(1):18-27.
Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells.
Fabrication and characterization of porous hyaluronic acid-collagen composite scaffolds. J Biomed Mater Res A. 2007 Aug; 82(2):323-35.
Fabrication and characterization of porous hyaluronic acid-collagen composite scaffolds.
Mintzer CM, Robertson DD, Rackemann S, Ewald FC, Scott RD, Spector M
Bone loss in the distal anterior femur after total knee arthroplasty. Clin Orthop Relat Res. 1990 Nov; (260):135-43.
Bone loss in the distal anterior femur after total knee arthroplasty.
Chondrogenic differentiation of adult mesenchymal stem cells and embryonic cells in collagen scaffolds. J Biomed Mater Res A. 2011 Nov; 99(2):275-82.
Chondrogenic differentiation of adult mesenchymal stem cells and embryonic cells in collagen scaffolds.
Chen P, Marsilio E, Goldstein RH, Yannas IV, Spector M
Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro. Tissue Eng. 2005 Sep-Oct; 11(9-10):1436-48.
Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro.
Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res. 2000 Jul; 18(4):557-64.
Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds.
Grottkau BE, Noordin S, Shortkroff S, Schaffer JL, Thornhill TS, Spector M
Effect of mechanical perturbation on the release of PGE(2) by macrophages in vitro. J Biomed Mater Res. 2002 Feb; 59(2):288-93.
Effect of mechanical perturbation on the release of PGE(2) by macrophages in vitro.
Murray MM, Bennett R, Zhang X, Spector M
Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. J Orthop Res. 2002 Jul; 20(4):875-80.
Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1.
Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices. Tissue Eng. 2003 Feb; 9(1):27-36.
Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices.
Hindman HB, Marty-Roix R, Tang JB, Jupiter JB, Simmons BP, Spector M
The Journal of bone and joint surgery. British volume
Regulation of expression of alpha-smooth muscle actin in cells of Dupuytren's contracture. J Bone Joint Surg Br. 2003 Apr; 85(3):448-55.
Regulation of expression of alpha-smooth muscle actin in cells of Dupuytren's contracture.
Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation. Tissue Eng. 2006 May; 12(5):1345-55.
Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation.
Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbits. Mol Vis. 2011; 17:3055-61.
Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbits.
Pancreatic calculi containing brushite: ultrastructure and pathogenesis. Calcif Tissue Int. 1986 Nov; 39(5):342-7.
Pancreatic calculi containing brushite: ultrastructure and pathogenesis.
Early tissue infiltrate in porous polyethylene implants into bone: a scanning electron microscope study. J Biomed Mater Res. 1975 Sep; 9(5):537-42.
Early tissue infiltrate in porous polyethylene implants into bone: a scanning electron microscope study.
Paschalis EP, Zhao Q, Tucker BE, Mukhopadhayay S, Bearcroft JA, Beals NB, Spector M, Nancollas GH
Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants. J Biomed Mater Res. 1995 Dec; 29(12):1499-505.
Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants.
Chamberlain LJ, Yannas IV, Hsu HP, Spector M
Connective tissue response to tubular implants for peripheral nerve regeneration: the role of myofibroblasts. J Comp Neurol. 2000 Feb 21; 417(4):415-30.
Connective tissue response to tubular implants for peripheral nerve regeneration: the role of myofibroblasts.
Lalor PA, Namba R, Mitchell SL, Bearcroff J, Beals N, Sledge CB, Spector M
Journal of long-term effects of medical implants
Migration of polyethylene particles around stable implants in an animal model. J Long Term Eff Med Implants. 1999; 9(4):261-72.
Migration of polyethylene particles around stable implants in an animal model.
Murray MM, Martin SD, Martin TL, Spector M
Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am. 2000 Oct; 82(10):1387-97.
Histological changes in the human anterior cruciate ligament after rupture.
Premdas J, Tang JB, Warner JP, Murray MM, Spector M
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res. 2001 Mar; 19(2):221-8.
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff.
Samuel RE, Lee CR, Ghivizzani SC, Evans CH, Yannas IV, Olsen BR, Spector M
Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices. Hum Gene Ther. 2002 May 01; 13(7):791-802.
Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices.
Breinan HA, Minas T, Hsu HP, Nehrer S, Shortkroff S, Spector M
Autologous chondrocyte implantation in a canine model: change in composition of reparative tissue with time. J Orthop Res. 2001 May; 19(3):482-92.
Autologous chondrocyte implantation in a canine model: change in composition of reparative tissue with time.
Kinner B, Pacicca DM, Gerstenfeld LC, Lee CA, Einhorn TA, Spector M
Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model. J Orthop Res. 2003 Jan; 21(1):20-7.
Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model.
Rong Y, Sugumaran G, Silbert JE, Spector M
Proteoglycans synthesized by canine intervertebral disc cells grown in a type I collagen-glycosaminoglycan matrix. Tissue Eng. 2002 Dec; 8(6):1037-47.
Proteoglycans synthesized by canine intervertebral disc cells grown in a type I collagen-glycosaminoglycan matrix.
Contractile forces generated by articular chondrocytes in collagen-glycosaminoglycan matrices. Biomaterials. 2004 Mar-Apr; 25(7-8):1299-308.
Contractile forces generated by articular chondrocytes in collagen-glycosaminoglycan matrices.
Effect of passage number and collagen type on the proliferative, biosynthetic, and contractile activity of adult canine articular chondrocytes in type I and II collagen-glycosaminoglycan matrices in vitro. Tissue Eng. 2004 Jan-Feb; 10(1-2):119-27.
Effect of passage number and collagen type on the proliferative, biosynthetic, and contractile activity of adult canine articular chondrocytes in type I and II collagen-glycosaminoglycan matrices in vitro.
Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng. 2007 Sep; 13(9):2227-37.
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid.
Spector M, Shortkroff S, Hsu HP, Lane N, Sledge CB, Thornhill TS
Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent. Clin Orthop Relat Res. 1990 Dec; (261):140-52.
Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent.
Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006 Sep; 12(9):2467-78.
Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells.
Vickers SM, Johnson LL, Zou LQ, Yannas IV, Gibson LJ, Spector M
Expression of alpha-smooth muscle actin by and contraction of cells derived from synovium. Tissue Eng. 2004 Jul-Aug; 10(7-8):1214-23.
Expression of alpha-smooth muscle actin by and contraction of cells derived from synovium.
Russlies M, Behrens P, Ehlers EM, Bröhl C, Vindigni C, Spector M, Kurz B
Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model. Cell Tissue Res. 2005 Jan; 319(1):133-42.
Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model.
Ambra LF, de Girolamo L, Niu W, Phan A, Spector M, Gomoll AH
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
No effect of topical application of tranexamic acid on articular cartilage. Knee Surg Sports Traumatol Arthrosc. 2019 Mar; 27(3):931-935.
No effect of topical application of tranexamic acid on articular cartilage.
Contractile behavior of smooth muscle actin-containing osteoblasts in collagen-GAG matrices in vitro: implant-related cell contraction. Biomaterials. 2000 Sep; 21(18):1867-77.
Contractile behavior of smooth muscle actin-containing osteoblasts in collagen-GAG matrices in vitro: implant-related cell contraction.
Biomaterials: taming the beast. J Biomed Mater Res. 1992 Jan; 26(1):1-5.
Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg. 1994 Jul; 21(3):437-44.
Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration.
Lim TC, Toh WS, Wang LS, Kurisawa M, Spector M
The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. Biomaterials. 2012 Apr; 33(12):3446-55.
The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells.
Ideas and inspiration: a remembrance of Philip J Boyne, DMD, MS, DSc. Biomed Mater. 2008 Sep; 3(3):030401.
Ideas and inspiration: a remembrance of Philip J Boyne, DMD, MS, DSc.
Phosphate starvation regulon of Salmonella typhimurium. J Bacteriol. 1986 May; 166(2):666-9.
Phosphate starvation regulon of Salmonella typhimurium.
Scanning electron microscopy of human prostatic corpora amylacea and corpora calculi, and prostatic calculi. Scan Electron Microsc. 1979; (3):713-20.
Scanning electron microscopy of human prostatic corpora amylacea and corpora calculi, and prostatic calculi.
Fracture of human dentin: a high resolution scanning electron microscope study. J Dent Res. 1976 Nov-Dec; 55(6):1136.
Fracture of human dentin: a high resolution scanning electron microscope study.
O'Neal CR, Gabriel WM, Turk AK, Libby SJ, Fang FC, Spector MP
RpoS is necessary for both the positive and negative regulation of starvation survival genes during phosphate, carbon, and nitrogen starvation in Salmonella typhimurium. J Bacteriol. 1994 Aug; 176(15):4610-6.
RpoS is necessary for both the positive and negative regulation of starvation survival genes during phosphate, carbon, and nitrogen starvation in Salmonella typhimurium.
Porous polymers for biological fixation. Clin Orthop Relat Res. 1988 Oct; (235):207-19.
Porous polymers for biological fixation.
Journal of the mechanical behavior of biomedical materials
Viscoelastic characterization of rat cerebral cortex and type I collagen scaffolds for central nervous system tissue engineering. J Mech Behav Biomed Mater. 2012 Aug; 12:63-73.
Viscoelastic characterization of rat cerebral cortex and type I collagen scaffolds for central nervous system tissue engineering.
Ma J, Tian WM, Hou SP, Xu QY, Spector M, Cui FZ
An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. Biomed Mater. 2007 Dec; 2(4):233-40.
An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model.
Johnson LL, Verioti C, Gelber J, Spector M, D'Lima D, Pittsley A
The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair. Knee. 2011 Dec; 18(6):402-6.
The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair.
Krevolin J, Liu JJ, Wallen A, Patel K, Dahl R, Hsu H-P, Kearney C, Spector M.
Tissue ingrowth in resorbable porous tissue scaffolds
Proceedings of the 35th Int. Conf on Advanced Ceramics and Composites. Tissue ingrowth in resorbable porous tissue scaffolds. 2011.
Proceedings of the 35th Int. Conf on Advanced Ceramics and Composites
Contact area as a critical determinant in the tribology of metal-on-polyethylene total joint arthroplasty
J. Tribology. Contact area as a critical determinant in the tribology of metal-on-polyethylene total joint arthroplasty. 2006; 128:113-121.
The conical cartilage of the cat's middle ear. J Laryngol Otol. 1985 Sep; 99(9):831-8.
The conical cartilage of the cat's middle ear.
Bone growth into porous high-density polyethylene. J Biomed Mater Res. 1976 Jul; 10(4):595-603.
Bone growth into porous high-density polyethylene.
Hsu HP, Garg A, Walker PS, Spector M, Ewald FC
Effect of knee component alignment on tibial load distribution with clinical correlation. Clin Orthop Relat Res. 1989 Nov; (248):135-44.
Effect of knee component alignment on tibial load distribution with clinical correlation.
Cheriyan T, Ready JE, Brick GW, Martin SD, Martin TL, Schmid TM, Padera RF, Spector M
Lubricin and smooth muscle a-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses. Acta Biomater. 2013 Mar; 9(3):5751-8.
Lubricin and smooth muscle a-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses.
Foster JW, Park YK, Penfound T, Fenger T, Spector MP
Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon. J Bacteriol. 1990 Aug; 172(8):4187-96.
Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon.
In vitro response of the bone marrow-derived mesenchymal stem cells seeded in a type-I collagen-glycosaminoglycan scaffold for skin wound repair under the mechanical loading condition. Mol Cell Biomech. 2009 Dec; 6(4):217-27.
In vitro response of the bone marrow-derived mesenchymal stem cells seeded in a type-I collagen-glycosaminoglycan scaffold for skin wound repair under the mechanical loading condition.
Collagen scaffolds incorporating select therapeutic agents to facilitate a reparative response in a standardized hemiresection defect in the rat spinal cord. Tissue Eng Part A. 2012 Oct; 18(19-20):2158-72.
Collagen scaffolds incorporating select therapeutic agents to facilitate a reparative response in a standardized hemiresection defect in the rat spinal cord.
Nehrer S, Breinan HA, Ramappa A, Young G, Shortkroff S, Louie LK, Sledge CB, Yannas IV, Spector M
Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. Biomaterials. 1997 Jun; 18(11):769-76.
Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes.
Biomaterials, medical devices, and artificial organs
Porous polysulfone as an attachment vehicle for orthopedic and dental implants. Biomater Med Devices Artif Organs. 1979; 7(1):23-9.
Porous polysulfone as an attachment vehicle for orthopedic and dental implants.
Role of loads and prosthesis material properties on the mechanics of the proximal femur after total hip arthroplasty. J Orthop Res. 1992 May; 10(3):405-22.
Role of loads and prosthesis material properties on the mechanics of the proximal femur after total hip arthroplasty.
A glimpse of tissue engineering in China. Tissue Eng. 2002 Apr; 8(2):169-74.
A glimpse of tissue engineering in China.
Porous titanium endosseous dental implants in Rhesus monkeys: microradiography and histological evaluation. J Biomed Mater Res. 1979 Nov; 13(6):843-56.
Porous titanium endosseous dental implants in Rhesus monkeys: microradiography and histological evaluation.
Mueller SM, Schneider TO, Shortkroff S, Breinan HA, Spector M
alpha-smooth muscle actin and contractile behavior of bovine meniscus cells seeded in type I and type II collagen-GAG matrices. J Biomed Mater Res. 1999 Jun 05; 45(3):157-66.
alpha-smooth muscle actin and contractile behavior of bovine meniscus cells seeded in type I and type II collagen-GAG matrices.
Collier JP, Mayor MB, Surprenant VA, Dauphinais LA, Surprenant HP, Jensen RE, Chae JC, Spector M, Shortkroff S, Sledge CB
Advances in implant-bone interface. Instr Course Lect. 1991; 40:89-113.
Biomanufacturing: a US-China National Science Foundation-sponsored workshop. Tissue Eng. 2006 May; 12(5):1169-81.
Biomanufacturing: a US-China National Science Foundation-sponsored workshop.
The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model. Biomaterials. 2012 Mar; 33(7):2050-9.
The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model.
Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury. J Neurosci Methods. 2012 Jul 30; 209(1):199-211.
Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury.
Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock waves. Ultrasound Med Biol. 2012 Oct; 38(10):1673-80.
Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock waves.
Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M
Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol. 1998 Dec; 154(2):315-29.
Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft.
Ultrastructure and pathogenesis of human urinary calculi. Br J Urol. 1978 Feb; 50(1):12-5.
Ultrastructure and pathogenesis of human urinary calculi.
Lee CR, Grodzinsky AJ, Hsu HP, Spector M
Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. J Orthop Res. 2003 Mar; 21(2):272-81.
Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model.