Catharina Ormandy Professor of Orthopedic Surgery
Anterior Cruciate Ligament Healing and Primary Repair. 2005; 13(3):151-156.
Anterior Cruciate Ligament Healing and Primary Repair
Fleming BC, Spindler KP, Palmer MP, Magarian EM, Murray MM
Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med. 2009 Aug; 37(8):1554-63.
Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model.
Murray, MM, Spindler, KP, Zurakowski, DA, Connolly, SA.
Enhancement of suture repair of the ACL using a collagen-PRP hydrogel. 2006.
Enhancement of suture repair of the ACL using a collagen-PRP hydrogel
Murray, MM., Spindler, K.P., Ballard, P., Welch, T., Nanney, LB.
Enhanced Histologic Repair in a Central Defect in the ACL with a Collagen-PRP Scaffold. J Orthop Res. 2007; 25(8):1007-1017.
Enhanced Histologic Repair in a Central Defect in the ACL with a Collagen-PRP Scaffold
Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM
Molecular therapy : the journal of the American Society of Gene Therapy
Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004 Aug; 10(2):327-36.
Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model.
Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res. 2010 Jun; 28(6):703-9.
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament.
Vavken P, Fleming BC, Mastrangelo AN, Machan JT, Murray MM
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy. 2012 May; 28(5):672-80.
Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model.
Proffen BL, Haslauer CM, Harris CE, Murray MM
Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression. Connect Tissue Res. 2013; 54(1):14-21.
Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression.
Musculoskeletal Medicine, Berstein J, editor
Ligaments. Musculoskeletal Medicine, Berstein J, editor. 2003.
Murray, M.M., Steinert, A., Evans, C., Pilapil, C., Palmer, G., Betz, O
In Situ IGF-1 Gene Transfer Enhances Healing Response in the Anterior Cruciate Ligament. 2005.
In Situ IGF-1 Gene Transfer Enhances Healing Response in the Anterior Cruciate Ligament
Murray MM, Magarian EM, Harrison SL, Mastrangelo AN, Zurakowski D, Fleming BC
The Journal of bone and joint surgery. American volume
The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am. 2010 Sep 01; 92(11):2039-49.
The effect of skeletal maturity on functional healing of the anterior cruciate ligament.
Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. Knee. 2012 Oct; 19(5):672-5.
Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells.
Murray MM., Murray MF., Marler JM., Spindler KP., Sawyer AJ., inventors
Biologic Replacement for Fibrin Clot. 2003.
Mesiha M, Zurakowski D, Soriano J, Nielson JH, Zarins B, Murray MM
Pathologic characteristics of the torn human meniscus. Am J Sports Med. 2007 Jan; 35(1):103-12.
Pathologic characteristics of the torn human meniscus.
Mahan ST, Murray MM, Woolf AD, Kasser JR
Increased blood lead levels in an adolescent girl from a retained bullet. A case report. J Bone Joint Surg Am. 2006 Dec; 88(12):2726-9.
Increased blood lead levels in an adolescent girl from a retained bullet. A case report.
The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials. 2001 Sep; 22(17):2393-402.
The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro.
Age dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res. 2010 Aug; 28(8):1107-12.
Age dependence of expression of growth factor receptors in porcine ACL fibroblasts.
Duretti Fufa, MD; Blake Shealy; May Jacobson, PhD; Sherwin Kevy, MD; Martha Meaney Murray, MD.
Journal of Oral and Maxillofacial Surgery, accepted for publication.
Activation of Platelet-Rich Plasma Using Soluble Type I Collagen. Journal of Oral and Maxillofacial Surgery, accepted for publication. 2007.
Activation of Platelet-Rich Plasma Using Soluble Type I Collagen
Murray MM., Spindler KP., Abreu E., Muller J., Nedder A., Kelly M., Frino J., Zurakowski D., Valenza M., Snyder BD., Palmer M., Connolly S
Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament.
Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament. 2007.
Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament
Murray, M. M., Mankin, H. J., Glowacki, J.
O’Leary, JP editor. The Physiologic Basis of Surgery
The Musculoskeletal System. O’Leary, JP editor. The Physiologic Basis of Surgery. 2007.
Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy. 2011 May; 27(5):704-16.
Treating anterior cruciate ligament tears in skeletally immature patients.
Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB
Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res. 2007 Aug; 25(8):1007-17.
Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold.
Murray, MM, Rice, K, Wright, RJ, Spector, M
The Effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold. J Orthop Res. 2003; 21:238-244.
The Effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold
TRITON-X is most effective among three decellularization agents for ACL tissue engineering. J Orthop Res. 2009 Dec; 27(12):1612-8.
TRITON-X is most effective among three decellularization agents for ACL tissue engineering.
Translational studies in anterior cruciate ligament repair. Tissue Eng Part B Rev. 2010 Feb; 16(1):5-11.
Translational studies in anterior cruciate ligament repair.
Proffen BL, McElfresh M, Fleming BC, Murray MM
A comparative anatomical study of the human knee and six animal species. Knee. 2012 Aug; 19(4):493-9.
A comparative anatomical study of the human knee and six animal species.
The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. Arthroscopy. 2011 Nov; 27(11):1573-83.
The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials.
Murray MM., Slocum A., Want YC., Walker D., Carvey M., Salameni A., inventors
Delivery Device for Tissue Repair. 2005.
Musculoskeletal Medicine, Bernstein J, editor
Meniscus. Musculoskeletal Medicine, Bernstein J, editor. 2003.
Methods and Procedures for Ligament Repair,
Methods and Procedures for Ligament Repair,. 2006.
Joshi SM, Mastrangelo AN, Magarian EM, Fleming BC, Murray MM
Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med. 2009 Dec; 37(12):2401-10.
Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament.
The Pediatric and Adolescent Knee, Micheli, LJ and Kocher, MS, eds
Biology and Gene-Based Therapy. The Pediatric and Adolescent Knee, Micheli, LJ and Kocher, MS, eds. 2006.
The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels.
The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels. 2007.
The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels
Kritsaneepaiboon S, Shah R, Murray MM, Kleinman PK
Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism. AJR Am J Roentgenol. 2009 Dec; 193(6):W540-5.
Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism.
Murray MM, Magarian E, Zurakowski D, Fleming BC
Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. Arthroscopy. 2010 Sep; 26(9 Suppl):S49-57.
Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite.
E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program
E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1998.
Murray, M.M., section editor for Basic Science
Musculoskeletal Medicine. Bernstein, J. Senior Editor
Musculoskeletal Medicine. Bernstein, J. Senior Editor. 2003.
Murray, MM., Murray, MF., Marler JM., inventors
Biologic Replacement for Fibrin Clot. 2001.
The Journal of the American Academy of Orthopaedic Surgeons
Clinical Approach in Youth Sports Medicine: Patients' and Guardians' Desired Characteristics in Sports Medicine Surgeons. J Am Acad Orthop Surg. 2018 Oct 12.
Clinical Approach in Youth Sports Medicine: Patients' and Guardians' Desired Characteristics in Sports Medicine Surgeons.
Pearse RV, Esshaki D, Tabin CJ, Murray MM
Genome-wide expression analysis of intra- and extraarticular connective tissue. J Orthop Res. 2009 Apr; 27(4):427-34.
Genome-wide expression analysis of intra- and extraarticular connective tissue.
Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger GJ, Murray MM
Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament. Am J Sports Med. 2010 Dec; 38(12):2528-34.
Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament.
Steinert A., Karl N., Pilapil C., Noth U., Evans CH., Murray, M.M.
Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament.
Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament. 2006.
Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament
Journal of biomedical materials research. Part A
Collagen density significantly affects the functional properties of an engineered provisional scaffold. J Biomed Mater Res A. 2010 Apr; 93(1):150-7.
Collagen density significantly affects the functional properties of an engineered provisional scaffold.
Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res. 2011 Sep; 29(9):1361-6.
Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold.
Yeh J., Shealy B., Jacobson M., Sherwin K., Hootnik J., Murray MM.
Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation.
Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation. 2007.
Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation
The Journal of bone and joint surgery. British volume
Osteochondral defects of the talus treated with autologous bone grafting. J Bone Joint Surg Br. 2004 May; 86(4):521-6.
Osteochondral defects of the talus treated with autologous bone grafting.
Kiapour AM, Yang DS, Badger GJ, Karamchedu NP, Murray MM, Fadale PD, Hulstyn MJ, Shalvoy RM, Fleming BC
Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery. Am J Sports Med. 2019 02; 47(2):303-311.
Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery.
Magarian EM, Vavken P, Connolly SA, Mastrangelo AN, Murray MM
Safety of intra-articular use of atelocollagen for enhanced tissue repair. Open Orthop J. 2012; 6:231-8.
Safety of intra-articular use of atelocollagen for enhanced tissue repair.
Guided Tissue Regeneration of the ACL: Preliminary Studies
Guided Tissue Regeneration of the ACL: Preliminary Studies. 1999.
Qiu, W, Murray, MM, Shortkroff, S, Lee, CR, Martin, SD, Spector, M
Outgrowth of Chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Would Repair and Regeneration. 2000; 18:383-391.
Outgrowth of Chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin
Kiapour AM, Sieker JT, Proffen BL, Lam TT, Fleming BC, Murray MM
Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PLoS One. 2019; 14(3):e0212662.
Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid.
Murray MM, Kiapour AM, Kalish LA, Ecklund K, Freiberger C, Henderson R, Kramer D, Micheli L, Yen YM, Fleming BC
Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair. Am J Sports Med. 2019 05; 47(6):1361-1369.
Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair.
Murray MM, Kalish LA, Fleming BC, Flutie B, Freiberger C, Henderson RN, Perrone GS, Thurber LG, Proffen BL, Ecklund K, Kramer DE, Yen YM, Micheli LJ
Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study. Orthop J Sports Med. 2019 Mar; 7(3):2325967118824356.
Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study.
Assistant Professor of Orthopedic Surgery
Beveridge JE, Proffen BL, Karamchedu NP, Chin KE, Sieker JT, Badger GJ, Kiapour AM, Murray MM, Fleming BC
Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair. J Orthop Res. 2019 10; 37(10):2249-2257.
Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair.
Kiapour AM, Ecklund K, Murray MM, Flutie B, Freiberger C, Henderson R, Kramer D, Micheli L, Thurber L, Yen YM, Fleming BC
Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery. Am J Sports Med. 2019 07; 47(8):1831-1843.
Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery.
Professor of Orthopedic Surgery (Biomaterials), Emeritus
Corresponding Member of the Faculty of Orthopedic Surgery
Clinical Approach in Youth Sports Medicine: Patients' and Guardians' Desired Characteristics in Sports Medicine Surgeons. J Am Acad Orthop Surg. 2019 Jul 01; 27(13):479-485.
Perrone GS, Webster KE, Imbriaco C, Portilla GM, Vairagade A, Murray MM, Kiapour AM
Risk of Secondary ACL Injury in Adolescents Prescribed Functional Bracing After ACL Reconstruction. Orthop J Sports Med. 2019 Nov; 7(11):2325967119879880.
Risk of Secondary ACL Injury in Adolescents Prescribed Functional Bracing After ACL Reconstruction.
Associate Professor of Orthopedic Surgery
Ayturk UM, Sieker JT, Haslauer CM, Proffen BL, Weissenberger MH, Warman ML, Fleming BC, Murray MM
Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis. PLoS One. 2020; 15(2):e0229449.
Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis.
Murray MM, Fleming BC, Badger GJ, Freiberger C, Henderson R, Barnett S, Kiapour A, Ecklund K, Proffen B, Sant N, Kramer DE, Micheli LJ, Yen YM
Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial. Am J Sports Med. 2020 05; 48(6):1305-1315.
Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial.
Arthroscopy, sports medicine, and rehabilitation
Resolution of Pain and Predictors of Postoperative Opioid use after Bridge-Enhanced Anterior Cruciate Ligament Repair and Anterior Cruciate Ligament Reconstruction. Arthrosc Sports Med Rehabil. 2020 Jun; 2(3):e219-e228.
Resolution of Pain and Predictors of Postoperative Opioid use after Bridge-Enhanced Anterior Cruciate Ligament Repair and Anterior Cruciate Ligament Reconstruction.
Barnett S, Badger GJ, Kiapour A, Yen YM, Henderson R, Freiberger C, Proffen B, Sant N, Trainor B, Fleming BC, Micheli LJ, Murray MM, Kramer DE
Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair. Tissue Eng Part A. 2020 07; 26(13-14):702-711.
Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair.
Freiberger C, Kiapour AM, Liu S, Henderson RN, Barnett S, Sant NJ, Proffen BL, Fleming BC, Ecklund K, Kramer DE, Micheli LJ, Murray MM, Yen YM
Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair. Orthop J Sports Med. 2020 Jul; 8(7):2325967120927655.
Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair.
Flannery SW, Kiapour AM, Edgar DJ, Murray MM, Fleming BC
Automated magnetic resonance image segmentation of the anterior cruciate ligament. J Orthop Res. 2021 04; 39(4):831-840.
Automated magnetic resonance image segmentation of the anterior cruciate ligament.
Flannery SW, Kiapour AM, Edgar DJ, Murray MM, Beveridge JE, Fleming BC
A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament. J Orthop Res. 2022 01; 40(1):277-284.
A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament.
Karamchedu NP, Murray MM, Sieker JT, Proffen BL, Portilla G, Costa MQ, Molino J, Fleming BC
Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model. Am J Sports Med. 2021 03; 49(3):667-674.
Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model.
Karamchedu NP, Fleming BC, Proffen BL, Sant NJ, Portilla G, Parola LR, Molino J, Murray MM
Terminal sterilization influences the efficacy of an extracellular matrix-blood composite for treating posttraumatic osteoarthritis in the rat model. J Orthop Res. 2022 03; 40(3):573-583.
Terminal sterilization influences the efficacy of an extracellular matrix-blood composite for treating posttraumatic osteoarthritis in the rat model.
Optimizing outcomes of ACL surgery-Is autograft reconstruction the only reasonable option? J Orthop Res. 2021 09; 39(9):1843-1850.
Optimizing outcomes of ACL surgery-Is autograft reconstruction the only reasonable option?
Karamchedu NP, Fleming BC, Donnenfield JI, Proffen BL, Costa MQ, Molino J, Murray MM
American journal of translational research
Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee. Am J Transl Res. 2021; 13(7):7667-7676.
Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee.
Costa MQ, Murray MM, Sieker JT, Karamchedu NP, Proffen BL, Fleming BC
Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee. PLoS One. 2021; 16(8):e0256765.
Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee.
Effects of radiation dose and nitrogen purge on collagen scaffold properties. J Biomater Appl. 2022 01; 36(6):1011-1018.
Effects of radiation dose and nitrogen purge on collagen scaffold properties.
Kiapour AM, Flannery SW, Murray MM, Miller PE, Proffen BL, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Barnett S, Ecklund K, Yen YM, Kramer DE, Micheli LJ, Fleming BC
Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment. Am J Sports Med. 2021 12; 49(14):3833-3841.
Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment.
Barnett SC, Murray MM, Badger GJ, Yen YM, Kramer DE, Sanborn R, Kiapour A, Proffen B, Sant N, Fleming BC, Micheli LJ
Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2021 Nov; 9(11):23259671211052530.
Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction.
Barnett SC, Murray MM, Flannery SW, Menghini D, Fleming BC, Kiapour AM, Proffen B, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Ecklund K, Yen YM, Kramer D, Micheli L
ACL Size, but Not Signal Intensity, Is Influenced by Sex, Body Size, and Knee Anatomy. Orthop J Sports Med. 2021 Dec; 9(12):23259671211063836.
ACL Size, but Not Signal Intensity, Is Influenced by Sex, Body Size, and Knee Anatomy.
Sanborn RM, Badger GJ, Yen YM, Murray MM, Christino MA, Proffen B, Sant N, Barnett S, Fleming BC, Kramer DE, Micheli LJ
Psychological Readiness to Return to Sport at 6 Months Is Higher After Bridge-Enhanced ACL Restoration Than Autograft ACL Reconstruction: Results of a Prospective Randomized Clinical Trial. Orthop J Sports Med. 2022 Feb; 10(2):23259671211070542.
Psychological Readiness to Return to Sport at 6 Months Is Higher After Bridge-Enhanced ACL Restoration Than Autograft ACL Reconstruction: Results of a Prospective Randomized Clinical Trial.
Flannery SW, Walsh EG, Sanborn RM, Chrostek CA, Costa MQ, Kaushal SG, Murray MM, Fleming BC, Kiapour AM
Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL). J Orthop Res. 2022 12; 40(12):2908-2913.
Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL).
Donnenfield JI, Karamchedu NP, Fleming BC, Molino J, Proffen BL, Murray MM
Articular cartilage and synovium may be important sources of post-surgical synovial fluid inflammatory mediators. Am J Transl Res. 2022; 14(3):1640-1651.
Articular cartilage and synovium may be important sources of post-surgical synovial fluid inflammatory mediators.
The FDA and Ensuring Safety and Effectiveness of Devices, Biologics, and Technology. J Am Acad Orthop Surg. 2022 Jul 15; 30(14):658-667.
The FDA and Ensuring Safety and Effectiveness of Devices, Biologics, and Technology.
Donnenfield JI, Karamchedu NP, Proffen BL, Molino J, Murray MM, Fleming BC
Predicting severity of cartilage damage in a post-traumatic porcine model: Synovial fluid and gait in a support vector machine. PLoS One. 2022; 17(6):e0268198.
Predicting severity of cartilage damage in a post-traumatic porcine model: Synovial fluid and gait in a support vector machine.
Menghini D, Kaushal SG, Flannery SW, Ecklund K, Murray MM, Fleming BC, Kiapour AM
Three-dimensional magnetic resonance imaging analysis shows sex-specific patterns in changes in anterior cruciate ligament cross-sectional area along its length. J Orthop Res. 2023 04; 41(4):771-778.
Three-dimensional magnetic resonance imaging analysis shows sex-specific patterns in changes in anterior cruciate ligament cross-sectional area along its length.
Flannery SW, Murray MM, Badger GJ, Ecklund K, Kramer DE, Fleming BC, Kiapour AM
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Early MRI-based quantitative outcomes are associated with a positive functional performance trajectory from 6 to 24 months post-ACL surgery. Knee Surg Sports Traumatol Arthrosc. 2023 May; 31(5):1690-1698.
Early MRI-based quantitative outcomes are associated with a positive functional performance trajectory from 6 to 24 months post-ACL surgery.
Flannery SW, Barnes DA, Costa MQ, Menghini D, Kiapour AM, Walsh EG, Kramer DE, Murray MM, Fleming BC
Automated segmentation of the healed anterior cruciate ligament from T2 * relaxometry MRI scans. J Orthop Res. 2023 03; 41(3):649-656.
Automated segmentation of the healed anterior cruciate ligament from T2 * relaxometry MRI scans.
Pinette MP, Molino J, Proffen BL, Murray MM, Fleming BC
Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery. Am J Sports Med. 2022 07; 50(9):2417-2423.
Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery.
Menghini D, Kaushal SG, Flannery SW, Ecklund K, Murray MM, Fleming BC, Kiapour AM, Proffen B, Sant N, Portilla G, Sanborn R, Freiberger C, Henderson R, Barnett S, Yen YM, Kramer DE, Micheli LJ
Changes in the Cross-Sectional Profile of Treated Anterior Cruciate Ligament Within 2 Years After Surgery. Orthop J Sports Med. 2022 Oct; 10(10):23259671221127326.
Changes in the Cross-Sectional Profile of Treated Anterior Cruciate Ligament Within 2 Years After Surgery.
Sanborn RM, Badger GJ, Fleming BC, Kiapour AM, Fadale PD, Hulstyn MJ, Owens BD, Proffen B, Sant N, Portilla G, Freiberger C, Henderson R, Barnett S, Costa M, Chrostek C, Ecklund K, Micheli LJ, Murray MM, Yen YM, Kramer DE
Preoperative Risk Factors for Subsequent Ipsilateral ACL Revision Surgery After an ACL Restoration Procedure. Am J Sports Med. 2023 01; 51(1):49-57.
Preoperative Risk Factors for Subsequent Ipsilateral ACL Revision Surgery After an ACL Restoration Procedure.
Parola LR, Pinette MP, Proffen BL, Sant NJ, Karamchedu NP, Costa MQ, Molino J, Fleming BC, Murray MM
Hydrogel treatment for idiopathic osteoarthritis in a Dunkin Hartley Guinea pig model. PLoS One. 2022; 17(11):e0278338.
Hydrogel treatment for idiopathic osteoarthritis in a Dunkin Hartley Guinea pig model.
Barnes DA, Badger GJ, Yen YM, Micheli LJ, Kramer DE, Fadale PD, Hulstyn MJ, Owens BD, Flannery SW, Ecklund K, Sanborn RM, Costa MQ, Chrostek C, Proffen BL, Sant N, Murray MM, Fleming BC, Kiapour AM
Quantitative MRI Biomarkers to Predict Risk of Reinjury Within 2 Years After Bridge-Enhanced ACL Restoration. Am J Sports Med. 2023 02; 51(2):413-421.
Quantitative MRI Biomarkers to Predict Risk of Reinjury Within 2 Years After Bridge-Enhanced ACL Restoration.
Flannery SW, Beveridge JE, Proffen BL, Walsh EG, Kramer DE, Murray MM, Kiapour AM, Fleming BC
Predicting anterior cruciate ligament failure load with T2* relaxometry and machine learning as a prospective imaging biomarker for revision surgery. Sci Rep. 2023 03 02; 13(1):3524.
Predicting anterior cruciate ligament failure load with T2* relaxometry and machine learning as a prospective imaging biomarker for revision surgery.
Donnenfield JI, Proffen BL, Fleming BC, Murray MM
Responding to ACL Injury and its Treatments: Comparative Gene Expression between Articular Cartilage and Synovium. Bioengineering (Basel). 2023 Apr 26; 10(5).
Responding to ACL Injury and its Treatments: Comparative Gene Expression between Articular Cartilage and Synovium.
Donnenfield JI, Karamchedu NP, Proffen BL, Molino J, Fleming BC, Murray MM
Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament. PLoS One. 2023; 18(5):e0284777.
Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament.
Han M, Singh M, Karimi D, Kim JY, Flannery SW, Ecklund K, Murray MM, Fleming BC, Gholipour A, Kiapour AM
medRxiv : the preprint server for health sciences
LigaNET: A multi-modal deep learning approach to predict the risk of subsequent anterior cruciate ligament injury after surgery. medRxiv. 2023 Jul 27.
LigaNET: A multi-modal deep learning approach to predict the risk of subsequent anterior cruciate ligament injury after surgery.
Donnenfield JI, Fleming BC, Proffen BL, Podury A, Murray MM
Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament. Osteoarthritis Cartilage. 2023 12; 31(12):1554-1566.
Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament.
How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration: AOA Critical Issues Symposium. J Bone Joint Surg Am. 2024 Mar 06; 106(5):466-471.
How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration: AOA Critical Issues Symposium.
Pruneski JA, Heyworth BE, Kocher MS, Tavabi N, Milewski MD, Kramer DE, Christino MA, Yen YM, Micheli LJ, Murray MM, Gilreath L, Kim A, Murray J, Kiapour AM
Prevalence and Predictors of Concomitant Meniscal and Ligamentous Injuries Associated With ACL Surgery: An Analysis of 20 Years of ACL Reconstruction at a Tertiary Care Children's Hospital. Am J Sports Med. 2024 01; 52(1):77-86.
Prevalence and Predictors of Concomitant Meniscal and Ligamentous Injuries Associated With ACL Surgery: An Analysis of 20 Years of ACL Reconstruction at a Tertiary Care Children's Hospital.
Nguyen AT, Aris IM, Snyder BD, Harris MB, Kang JD, Murray M, Rodriguez EK, Nazarian A
Musculoskeletal health: an ecological study assessing disease burden and research funding. Lancet Reg Health Am. 2024 Jan; 29:100661.
Musculoskeletal health: an ecological study assessing disease burden and research funding.
American Academy of Orthopaedic Surgeons Technology Overview Summary: Platelet-Rich Plasma (PRP) for Knee Osteoarthritis. J Am Acad Orthop Surg. 2024 Apr 01; 32(7):296-301.
American Academy of Orthopaedic Surgeons Technology Overview Summary: Platelet-Rich Plasma (PRP) for Knee Osteoarthritis.
Kaushal SG, Kim JY, Singh M, Han M, Flannery SW, Barnes DA, Ecklund K, Murray MM, Badger GJ, Fleming BC, Kiapour AM
Comprehensive evaluation of magnetic resonance imaging sequences for signal intensity based assessment of anterior cruciate ligament healing following surgical treatment. J Orthop Res. 2024 07; 42(7):1587-1598.
Comprehensive evaluation of magnetic resonance imaging sequences for signal intensity based assessment of anterior cruciate ligament healing following surgical treatment.
Pruneski JA, Tavabi N, Heyworth BE, Kocher MS, Kramer DE, Christino MA, Milewski MD, Yen YM, Micheli L, Murray MM, Garcia Andujar RA, Kiapour AM
Prevalence and Predictors of Concomitant Meniscal Surgery During Pediatric and Adolescent ACL Reconstruction: Analysis of 4729 Patients Over 20 Years at a Tertiary-Care Regional Children's Hospital. Orthop J Sports Med. 2024 Mar; 12(3):23259671241236496.
Prevalence and Predictors of Concomitant Meniscal Surgery During Pediatric and Adolescent ACL Reconstruction: Analysis of 4729 Patients Over 20 Years at a Tertiary-Care Regional Children's Hospital.
Hogue GD, Liu DS, Kaushal SG, Tavabi N, Feldman L, Stracciolini A, Shore B, Hedequist D, Bae D, Meehan W, Kim YJ, Kocher M, Murray MM, Kiapour AM
Telehealth Potential in Pediatric Orthopaedics and Sports Medicine Care is Comparable to In-Person Care But Disparities Remain. J Pediatr Orthop. 2024 Jul 01; 44(6):379-385.
Telehealth Potential in Pediatric Orthopaedics and Sports Medicine Care is Comparable to In-Person Care But Disparities Remain.
Pediatric and Adolescent Distal Radius Fractures: Current Concepts and Treatment Recommendations. J Am Acad Orthop Surg. 2024 Nov 01; 32(21):e1079-e1089.
Pediatric and Adolescent Distal Radius Fractures: Current Concepts and Treatment Recommendations.
Fleming BC, Baranker B, Badger GJ, Kiapour AM, Ecklund K, Micheli LJ, Murray MM
Bridge-Enhanced Anterior Cruciate Ligament Restoration: 6-Year Results From the First-in-Human Cohort Study. Orthop J Sports Med. 2024 Aug; 12(8):23259671241260632.
Bridge-Enhanced Anterior Cruciate Ligament Restoration: 6-Year Results From the First-in-Human Cohort Study.
Palmer MP, Abreu EL, Mastrangelo A, Murray MM
Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds. J Orthop Res. 2009 Jul; 27(7):964-71.
Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds.
Storage conditions do not have detrimental effect on allograft collagen or scaffold performance. Cell Tissue Bank. 2009 Nov; 10(4):333-40.
Storage conditions do not have detrimental effect on allograft collagen or scaffold performance.
Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery. Am J Sports Med. 2013 Aug; 41(8):1762-70.
Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery.
Rodeo SA, Boden SD, Murray MM, Einhorn TA
2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues. J Bone Joint Surg Am. 2013 Aug 07; 95(15):e109.
2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues.
Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013. J Orthop Res. 2013 Oct; 31(10):1501-6.
Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013.
Barnes DA, Murray CJ, Molino J, Beveridge JE, Kiapour AM, Murray MM, Fleming BC
Advancement of an automatic segmentation pipeline for metallic artifact removal in post-surgical ACL MRI. Magn Reson Imaging. 2025 Sep; 121:110417.
Advancement of an automatic segmentation pipeline for metallic artifact removal in post-surgical ACL MRI.
Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM
Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. Osteoarthritis Cartilage. 2013 Dec; 21(12):1950-7.
Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury.
Haslauer CM, Proffen BL, Johnson VM, Murray MM
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. Wound Repair Regen. 2014 Jan-Feb; 22(1):103-10.
Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury.
Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014; 3(2):20-31.
Basic science of anterior cruciate ligament injury and repair.
Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture. J Orthop Res. 2014 Feb; 32(2):291-5.
Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture.
Biercevicz AM, Murray MM, Walsh EG, Miranda DL, Machan JT, Fleming BC
T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL. J Orthop Res. 2014 Apr; 32(4):492-9.
T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL.
Biercevicz AM, Walsh EG, Murray MM, Akelman MR, Fleming BC
Improving the clinical efficiency of T2(*) mapping of ligament integrity. J Biomech. 2014 Jul 18; 47(10):2522-5.
Improving the clinical efficiency of T2(*) mapping of ligament integrity.
Head of the Department of Orthopedic Surgery at Boston Children's Hospital
Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM
Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2015 Apr; 23(4):1161-70.
Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction.
Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, Birkelund S, Murray MM, Warman ML, Stensballe A, Steen H
A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014 Oct 03; 13(10):4377-87.
A normative study of the synovial fluid proteome from healthy porcine knee joints.
Kiapour AM, Shalvoy MR, Murray MM, Fleming BC
Clinical orthopaedics and related research
Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50.
Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders.
Haslauer CM, Proffen BL, Johnson VM, Hill A, Murray MM
Journal of inflammation (London, England)
Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. J Inflamm (Lond). 2014; 11(1):34.
Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model.
Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM
Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb; 43(2):320-30.
Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model.
Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. Clin Orthop Relat Res. 2015 Aug; 473(8):2599-608.
Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model.
Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM
Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. J Orthop Res. 2015 Jul; 33(7):1015-23.
Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing.
Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy. 2015 May; 31(5):990-7.
Bio-enhanced repair of the anterior cruciate ligament.
Hutchinson ID, Rodeo SA, Perrone GS, Murray MM
Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? J Knee Surg. 2015 Feb; 28(1):19-28.
Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair?
Kiapour AM, Fleming BC, Proffen BL, Murray MM
Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31.
Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model.
Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC
T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. J Orthop Res. 2015 Aug; 33(8):1180-7.
T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model.
Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Murray MM
Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. J Biomater Appl. 2015 Oct; 30(4):435-49.
Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds.
Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM
Arthritis & rheumatology (Hoboken, N.J.)
Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 07; 68(7):1637-47.
Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis.
Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC
Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016 06; 34(6):995-1003.
Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat.
Kelly BA, Proffen BL, Haslauer CM, Murray MM
Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. J Orthop Res. 2016 Apr; 34(4):623-9.
Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold.
A Histologic Study of Enhanced ACL Repair
The Effect of Age on Functional ACL Healing
Non-invasive assessment of ligament healing in vivo
SCAFFOLD OPTIMIZATION FOR HEALING OF THE RUPTURED HUMAN
Enhanced Primary Repair of Ligament Injuries
A Novel Mechanism for Intra-articular Nonunion
Bio-enhanced ACL Repair as a Modular of Post-traumatic Osteoarthritis
Proffen BL, Perrone GS, Roberts G, Murray MM
Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval. Ann Biomed Eng. 2015 Mar; 43(3):805-18.
Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval.
Proffen BL, Nielson JH, Zurakowski D, Micheli LJ, Curtis C, Murray MM
The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair. Orthop J Sports Med. 2014 May 01; 2(5).
The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair.
The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots. Materials (Basel). 2011 Aug 20; 4(8):1469-1482.
The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots.
Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC
Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech. 2016 10 03; 49(14):3559-3563.
Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model.
Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo. Orthop J Sports Med. 2013 Nov; 1(6).
Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo.
Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, Micheli LJ
The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study. Orthop J Sports Med. 2016 Nov; 4(11):2325967116672176.
The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study.
Murray MM, Spindler KP, Devin C, Snyder BS, Muller J, Takahashi M, Ballard P, Nanney LB, Zurakowski D
Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res. 2006 Apr; 24(4):820-30.
Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL.
Steinert AF, Weber M, Kunz M, Palmer GD, Nöth U, Evans CH, Murray MM
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008 Mar; 29(7):904-16.
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament.
Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am J Sports Med. 2004 Sep; 32(6):1484-91.
Interspecies variation in the fibroblast distribution of the anterior cruciate ligament.
Beveridge JE, Walsh EG, Murray MM, Fleming BC
Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions. J Biomech. 2017 May 03; 56:117-121.
Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions.
Spindler KP, Murray MM, Detwiler KB, Tarter JT, Dawson JM, Nanney LB, Davidson JM
The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res. 2003 Mar; 21(2):245-9.
The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament.
Spindler KP, Murray MM, Devin C, Nanney LB, Davidson JM
The central ACL defect as a model for failure of intra-articular healing. J Orthop Res. 2006 Mar; 24(3):401-6.
The central ACL defect as a model for failure of intra-articular healing.
Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M
Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Wound Repair Regen. 2000 Sep-Oct; 8(5):383-91.
Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin.
Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M
Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res. 2001 Jul; 19(4):659-64.
Distribution of smooth muscle actin-containing cells in the human meniscus.
The potential for primary repair of the ACL. Sports Med Arthrosc Rev. 2011 Mar; 19(1):44-9.
The potential for primary repair of the ACL.
Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM
Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med. 2011 Apr; 39(4):729-34.
Platelet activation by collagen provides sustained release of anabolic cytokines.
Effect of anterior cruciate healing on the uninjured ligament insertion site. J Orthop Res. 2012 Jan; 30(1):86-94.
Effect of anterior cruciate healing on the uninjured ligament insertion site.
Fleming BC, Vajapeyam S, Connolly SA, Magarian EM, Murray MM
The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomech. 2011 Nov 10; 44(16):2843-6.
The use of magnetic resonance imaging to predict ACL graft structural properties.
The Effect of Insoluble Collagen Morphology on Fibroblast Migration, Proliferation and Collagen Production. 2005.
The Effect of Insoluble Collagen Morphology on Fibroblast Migration, Proliferation and Collagen Production
Mastrangelo AN, Vavken P, Fleming BC, Harrison SL, Murray MM
Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Orthop Res. 2011 Jul; 29(7):1002-7.
Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model.
Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM
Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 12; 35(12):2606-2612.
Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair.
Murray MM, Spindler KP, Abreu E, Muller JA, Nedder A, Kelly M, Frino J, Zurakowski D, Valenza M, Snyder BD, Connolly SA
Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res. 2007 Jan; 25(1):81-91.
Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament.
Jacobson M, Fufa D, Abreu EL, Kevy S, Murray MM
Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model. Wound Repair Regen. 2008 May-Jun; 16(3):370-8.
Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model.
Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC
Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 01; 36(1):318-329.
Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis.
Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res. 2013 Jan; 31(1):29-34.
Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts.
Fleming BC, Carey JL, Spindler KP, Murray MM
Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. J Orthop Res. 2008 Nov; 26(11):1500-5.
Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study.
Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res. 1999 Jan; 17(1):18-27.
Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells.
Steinert, AF., Chen, F., Evans, CH., Murray, MM
Novel Biological Approaches to Enhance Primary Repair of the Anterior Cruciate Ligament. 2004; 81-83.
Novel Biological Approaches to Enhance Primary Repair of the Anterior Cruciate Ligament
Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee. 2011 Aug; 18(4):247-51.
Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals.
Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage. Orthop J Sports Med. 2017 Aug; 5(8):2325967117723886.
Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage.
Planning A Clinical Trial of Bio-enhanced ACL Repair versus ACL Reconstruction
Biologic Replacement for Fibrin Clot for Intra-articular Use
Biologic Replacement for Fibrin Clot for Intra-articular Use. 2000.
Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res. 2000 Jul; 18(4):557-64.
Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds.
Murray MM, Bennett R, Zhang X, Spector M
Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. J Orthop Res. 2002 Jul; 20(4):875-80.
Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1.
Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis. Knee. 2011 Jan; 18(1):42-6.
Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis.
Mastrangelo AN, Haus BM, Vavken P, Palmer MP, Machan JT, Murray MM
Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res. 2010 Aug; 28(8):1100-6.
Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals.
Anterior Cruciate Ligament Healing and Primary Repair. Sports Medicine and Arthroscopy Review. 2005; 13(3):151-155.
Steinert, A., Palmer, G., Betz, O., Gouze, I., Gouze, JM., Pilapil, C., Ghivizzani, S., Evans, C., Murray, M.M.
In Situ IGF-1 Gene Transfer for Enhancing Healing of the ACL – Evaluation in an in vitro model. Basic Science Poster Prize. 2004.
In Situ IGF-1 Gene Transfer for Enhancing Healing of the ACL – Evaluation in an in vitro model. Basic Science Poster Prize
Murray, M. M., Rice, K. R., Spector, M. S.,
The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds.
The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds. 2002.
The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds
Murray MM, Martin SD, Martin TL, Spector M
Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am. 2000 Oct; 82(10):1387-97.
Histological changes in the human anterior cruciate ligament after rupture.
Premdas J, Tang JB, Warner JP, Murray MM, Spector M
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res. 2001 Mar; 19(2):221-8.
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff.
Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, Steinert A
The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res. 2006 Mar; 24(3):508-15.
The effect of thrombin on ACL fibroblast interactions with collagen hydrogels.
Kocher MS, Kasser JR, Waters PM, Bae D, Snyder BD, Hresko MT, Hedequist D, Karlin L, Kim YJ, Murray MM, Millis MB, Emans JB, Dichtel L, Matheney T, Lee BM
Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial. J Bone Joint Surg Am. 2007 Apr; 89(4):706-12.
Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial.
Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A. 2010 May; 16(5):1479-89.
Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture.
Fufa D., Shealy B., Jacobson M., Kevy S., Murray MM.
Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels.
Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels. 2007.
Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels
Biologic Replacement for Fibrin Clot. 2005.
Mastrangelo AN, Magarian EM, Palmer MP, Vavken P, Murray MM
The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res. 2010 May; 28(5):644-51.
The effect of skeletal maturity on the regenerative function of intrinsic ACL cells.
Haddad-Weber M, Prager P, Kunz M, Seefried L, Jakob F, Murray MM, Evans CH, Nöth U, Steinert AF
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy. 2010 Jul; 12(4):505-13.
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.
The death of articular chondrocytes after intra-articular fracture in humans. J Trauma. 2004 Jan; 56(1):128-31.
The death of articular chondrocytes after intra-articular fracture in humans.
Strategies to improve anterior cruciate ligament healing and graft placement. Am J Sports Med. 2008 Jan; 36(1):176-89.
Strategies to improve anterior cruciate ligament healing and graft placement.
Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008 Apr; 66(4):684-90.
Activation of platelet-rich plasma using soluble type I collagen.
Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC
Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res. 2009 May; 27(5):639-45.
Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study.
Biologic Replacement for Fibrin Clot for Intra-articular Use, Provisional application
Biologic Replacement for Fibrin Clot for Intra-articular Use, Provisional application. 1999.
Effect of the intra-articular environment on healing of the ruptured anterior cruciate ligament. 2001.
Effect of the intra-articular environment on healing of the ruptured anterior cruciate ligament
E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1999.
Biercevicz AM, Miranda DL, Machan JT, Murray MM, Fleming BC
In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model. Am J Sports Med. 2013 Mar; 41(3):560-6.
In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model.
The Physiologic Basis of Surgery, O'Leary JP, editor
The Musculoskeletal System. The Physiologic Basis of Surgery, O'Leary JP, editor. 2002.
Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB
Enhanced Histologic Repair in a Central Defect in the Anterior Cruciate Ligament with a Collagen-Platelet Rich Plasma Scaffold. 2007.
Enhanced Histologic Repair in a Central Defect in the Anterior Cruciate Ligament with a Collagen-Platelet Rich Plasma Scaffold
Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC
The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res. 2009 May; 27(5):631-8.
The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model.
Beveridge JE, Machan JT, Walsh EG, Kiapour AM, Karamchedu NP, Chin KE, Proffen BL, Sieker JT, Murray MM, Fleming BC
Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res. 2018 06; 36(6):1701-1709.
Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL.
Vavken P, Saad FA, Fleming BC, Murray MM
VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL. Knee Surg Sports Traumatol Arthrosc. 2011 Oct; 19(10):1675-82.
VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL.
Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, Nöth U, Murray MM, Evans CH, Porter RM
Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10):1375-88.
Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells.
Murray, M. M., Martin, S. D., Spector, M.
Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon.
Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon. 2002.
Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon
Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB.
Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds.
Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds. 2007.
Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds
Murray, M. M., Sawyer, A., Zurakowski, D., Gerbino, P., Micheli, L.
The effect of age on the response to injury in the human ACL.
The effect of age on the response to injury in the human ACL. 2002.
The effect of age on the response to injury in the human ACL
Current status and potential of primary ACL repair. Clin Sports Med. 2009 Jan; 28(1):51-61.
Current status and potential of primary ACL repair.
Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res. 2012 Jan; 30(1):79-85.
Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression.
Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM
Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. Arthroscopy. 2013 Jan; 29(1):122-32.
Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study.
Murray, M. M., Dawson, C., Kocolas, I., Spector, M.
Gender differences in the histology of the human anterior cruciate ligament.
Gender differences in the histology of the human anterior cruciate ligament. 2001.
Gender differences in the histology of the human anterior cruciate ligament
Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM
Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20.
Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis.