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Mentoring - Current Student Opportunities
Migraine and Intracranial Headache Research [login at prompt]Available: 5/12/2011, Expires: 9/30/2012
Opportunities are available to study neuron-immune and endocrinological mechanisms that play a role in migraine and other intracranial headaches.
Neuro-immune-endocrine mechanisms of migraine [login at prompt]
Available: 8/1/2011, Expires: 7/1/2013
To understand how the immune and endocrine systems (sex and stress hormones) influence the triggering of migraine using animals models.
The student's role in this project is to actively engage in numerous types of research methods including in vivo electrophysiology, pain behavior, histology and pharmacology in order to investigate a number of specific hypothesis-driven research questions related to the origin of migraine and other types of headache (e.g. alcohol hangover) and the mechanims that promote increases sensitivity to headache triggers with focus in various hormonal conditions as well as sex. The Student is expected to be able to help run various experimental paradigms, collect data and take active part in its analysis.
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All | Timeline
List All | Timeline
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
- Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14.View in: PubMed
- Verster JC, Stephens R, Penning R, Rohsenow D, McGeary J, Levy D, McKinney A, Finnigan F, Piasecki TM, Adan A, Batty GD, Fliervoet LA, Heffernan T, Howland J, Kim DJ, Kruisselbrink LD, Ling J, McGregor N, Murphy RJ, van Nuland M, Oudelaar M, Parkes A, Prat G, Reed N, Slutske WS, Smith G, Young M. The alcohol hangover research group consensus statement on best practice in alcohol hangover research. Curr Drug Abuse Rev. 2010 Jun; 3(2):116-26.View in: PubMed
- Levy D. Migraine pain and nociceptor activation--where do we stand? Headache. 2010 May; 50(5):909-16.View in: PubMed
- Levy D. Migraine pain, meningeal inflammation, and mast cells. Curr Pain Headache Rep. 2009 Jun; 13(3):237-40.View in: PubMed
- Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7.View in: PubMed
- Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 6; 452(1):33-6.View in: PubMed
- Zhang Y, Guo X, Saitz R, Levy D, Sartini E, Niu J, Ellison RC. Secular trends in alcohol consumption over 50 years: the Framingham Study. Am J Med. 2008 Aug; 121(8):695-701.View in: PubMed
- Zhang XC, Levy D. Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia. 2008 Mar; 28(3):276-84.View in: PubMed
- Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22.View in: PubMed
- Oyama N, Gona P, Salton CJ, Chuang ML, Jhaveri RR, Blease SJ, Manning AR, Lahiri M, Botnar RM, Levy D, Larson MG, O'Donnell CJ, Manning WJ. Differential impact of age, sex, and hypertension on aortic atherosclerosis: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):155-9.View in: PubMed
- Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83.View in: PubMed
- Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12.View in: PubMed
- Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76.View in: PubMed
- Rifai N, Ballantyne CM, Cushman M, Levy D, Myers GL. Point: high-sensitivity C-reactive protein and cardiac C-reactive protein assays: is there a need to differentiate? Clin Chem. 2006 Jul; 52(7):1254-6.View in: PubMed
- Morita H, Larson MG, Barr SC, Vasan RS, O'Donnell CJ, Hirschhorn JN, Levy D, Corey D, Seidman CE, Seidman JG, Benjamin EJ. Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Circulation. 2006 Jun 13; 113(23):2697-705.View in: PubMed
- Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8.View in: PubMed
- Strassman AM, Levy D. Response properties of dural nociceptors in relation to headache. J Neurophysiol. 2006 Mar; 95(3):1298-306.View in: PubMed
- Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705.View in: PubMed
- Mukamal KJ, Massaro JM, Ault KA, Mittleman MA, Sutherland PA, Lipinska I, Levy D, D'Agostino RB, Tofler GH. Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study. Alcohol Clin Exp Res. 2005 Oct; 29(10):1906-12.View in: PubMed
- Zochodne DW, Levy D. Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell Mol Biol (Noisy-le-grand). 2005 Sep 5; 51(3):255-67.View in: PubMed
- Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61.View in: PubMed
- Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60.View in: PubMed
- Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8.View in: PubMed
- Strassman AM, Levy D. The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport. 2004 Jun 28; 15(9):1409-12.View in: PubMed
- Strassman AM, Weissner W, Williams M, Ali S, Levy D. Axon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol. 2004 May 31; 473(3):364-76.View in: PubMed
- Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 Aug; 92(2):766-72.View in: PubMed
- Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9.View in: PubMed
- Levy D, Zochodne DW. NO pain: potential roles of nitric oxide in neuropathic pain. Pain Pract. 2004 Mar; 4(1):11-8.View in: PubMed
- Meigs JB, Larson MG, D'Agostino RB, Levy D, Clouse ME, Nathan DM, Wilson PW, O'Donnell CJ. Coronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study. Diabetes Care. 2002 Aug; 25(8):1313-9.View in: PubMed
- Jaffer FA, O'Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 May 1; 22(5):849-54.View in: PubMed
- Levy D, Strassman AM. Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors. J Physiol. 2002 Jan 15; 538(Pt 2):483-93.View in: PubMed
- Levy D, Kubes P, Zochodne DW. Delayed peripheral nerve degeneration, regeneration, and pain in mice lacking inducible nitric oxide synthase. J Neuropathol Exp Neurol. 2001 May; 60(5):411-21.View in: PubMed
- Levy D, Tal M, Höke A, Zochodne DW. Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury. Eur J Neurosci. 2000 Jul; 12(7):2323-32.View in: PubMed
- Levy D, Zochodne DW. Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000 Jun; 86(3):265-71.View in: PubMed
- Levy D, Höke A, Zochodne DW. Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain. Neurosci Lett. 1999 Feb 5; 260(3):207-9.View in: PubMed
- Zochodne DW, Levy D, Zwiers H, Sun H, Rubin I, Cheng C, Lauritzen M. Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves. Neuroscience. 1999; 91(4):1515-27.View in: PubMed
- Levy D, Zochodne DW. Local nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci. 1998 May; 10(5):1846-55.View in: PubMed
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