Harvard Catalyst Profiles

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Yiying Zhang, M.D., Ph.D.

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  1. 1R21AG065606-01A1 (Zhang,Yiying) Sep 1, 2020 - Aug 31, 2022
    NIA
    MICROBIOME DYSBIOSIS AND POSTOPERATIVE DELIRIUM PATHOGENESIS
    Role Description: Postoperative delirium, the most common postoperative complication among senior patients, is an acute condition characterized by a state of confusion and is associated with substantially increased rates of morbidity and mortality, cost of care, and risk of developing Alzheimer’s disease and related dementias. However, the pathogenesis of postoperative delirium remains largely unknown. The proposed research will determine whether the interaction of age-associated gut microbiota with anesthesia/surgery-induced neuroinflammation can contribute to the brain mitochondrial dysfunction and delirium-like behavior in mice, which will ultimately lead to targeted interventions (e.g., treatment with probiotics) for the postoperative delirium.
    Role: PI

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.