Whitman, Malcolm
completed student projects: Dental Health Care for Special Needs Individuals: Trinidad and Tobago Summer Camp Case Study
completed student projects: Menthol Cigarettes and Tobacco Dependence in Elderly Nursing Home Residents
completed student projects: Breast Cancer Bone Metastasis: RANKL signalling and MMP-2 mediated invasion
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research areas: Transforming Growth Factor beta
research areas: Xenopus
research areas: Xenopus Proteins
research areas: Bone Morphogenetic Proteins
research areas: Quinazolinones
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linked information resource: The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.

TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
PubMed Identifier: 18234181
author list: Ho DM, Whitman M
published in: Developmental biology
information resource reference: TGF-beta signaling is required for multiple processes during Xenopus tail regeneration. Dev Biol. 2008 Mar 01; 315(1):203-16.
journal title abbreviation: Dev Biol
publication date: 2008-01-03T00:00:00
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linked information resource: Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.

Authorship 126560
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linked information resource: Smad4 and FAST-1 in the assembly of activin-responsive factor.

Nodal signaling in early vertebrate embryos: themes and variations.
PubMed Identifier: 11709181
author list: Whitman M
published in: Developmental cell
information resource reference: Nodal signaling in early vertebrate embryos: themes and variations. Dev Cell. 2001 Nov; 1(5):605-17.
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Novel Nutrient-sensing Pathway Suppresses Pathologic Tissue Remodeling
end date: 2020-10-31
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Xenopus
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Quinazolinones
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Transforming Growth Factor beta
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Xenopus Proteins
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Bone Morphogenetic Proteins
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Cell Biology
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Wyss Institute
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Kirschner, Marc
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Mazitschek, Ralph
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Keller, Tracy
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White, Robert
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Tabin, Clifford
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Lai, Mesou
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Gamer, Laura
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Zon, Leonard
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Ho, Diana
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Levin, Michael
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Perrimon, Norbert
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Instructor in Developmental Biology
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Authorship 131407
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linked information resource: Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled.

Authorship 1238173
type: Authorship
author rank in publication: 13
linked author: Whitman, Malcolm
linked information resource: Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
PubMed Identifier: 32253314
author list: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells. Proc Natl Acad Sci U S A. 2020 04 21; 117(16):8900-8911.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-04-06T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1302
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author rank in publication: 1
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linked information resource: TGFbeta signaling at the summit.

Authorship 136424
type: Authorship
author rank in publication: 1
linked author: Whitman, Malcolm
linked information resource: Nodal signaling in early vertebrate embryos: themes and variations.

Authorship 140817
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author rank in publication: 11
linked author: Whitman, Malcolm
linked information resource: Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

Authorship 1380182
type: Authorship
author rank in publication: 12
linked author: Whitman, Malcolm
linked information resource: The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
PubMed Identifier: 34329392
author list: Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R
published in: Blood
information resource reference: The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation. Blood. 2022 01 06; 139(1):104-117.
journal title abbreviation: Blood
publication date: 2022-01-06T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 176543
type: Authorship
author rank in publication: 1
linked author: Whitman, Malcolm
linked information resource: Smads and early developmental signaling by the TGFbeta superfamily.

Authorship 1428072
type: Authorship
author rank in publication: 8
linked author: Whitman, Malcolm
linked information resource: Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb.

Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb.
PubMed Identifier: 35080046
author list: Maridas DE, Gamer L, Moore ER, Doedens AM, Yu Y, Ionescu A, Revollo L, Whitman M, Rosen V
published in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
information resource reference: Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb. J Bone Miner Res. 2022 04; 37(4):764-775.
journal title abbreviation: J Bone Miner Res
publication date: 2022-02-16T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 171153
type: Authorship
author rank in publication: 1
linked author: Whitman, Malcolm
linked information resource: p53 and TGF-beta in development: prelude to tumor suppression?

Authorship 1483764
type: Authorship
author rank in publication: 11
linked author: Whitman, Malcolm
linked information resource: Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
PubMed Identifier: 36008486
author list: Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R
published in: Nature communications
information resource reference: Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022 08 25; 13(1):4976.
journal title abbreviation: Nat Commun
publication date: 2022-08-25T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 190768
type: Authorship
author rank in publication: 3
linked author: Whitman, Malcolm
linked information resource: A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos.

George Jacob and Jacqueline Hazel Leder Professor of Genetics
is primary position: true
position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: George Jacob and Jacqueline Hazel Leder Professor of Genetics
position in organization: Harvard Medical School

Corresponding Member of the Faculty of Restorative Dentistry and Biomaterials Sciences
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position in department: Rest Dent + Biomaterials
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Corresponding Member of the Faculty of Restorative Dentistry and Biomaterials Sciences
position in organization: Harvard School of Dental Medicine

Authorship 268487
type: Authorship
author rank in publication: 3
linked author: Whitman, Malcolm
linked information resource: A transcriptional partner for MAD proteins in TGF-beta signalling.

Professor of Developmental Biology
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position in department: Developmental Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Professor of Developmental Biology
position in organization: Harvard School of Dental Medicine

John Franklin Enders University Professor of Systems Biology
is primary position: true
position in department: Systems Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
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HR job title: John Franklin Enders University Professor of Systems Biology
position in organization: Harvard Medical School

Instructor in Developmental Biology, Part-time
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position in department: Developmental Biology
position in division: Harvard Dental Center
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HR job title: Instructor in Developmental Biology, Part-time
position in organization: Harvard School of Dental Medicine

Authorship 431818
type: Authorship
author rank in publication: 6
linked author: Whitman, Malcolm
linked information resource: New roles for FoxH1 in patterning the early embryo.

Doctors Samuel and Ida Gelfand Professor of Developmental Biology
is primary position: true
position in department: Developmental Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Doctors Samuel and Ida Gelfand Professor of Developmental Biology
position in organization: Harvard School of Dental Medicine

Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.
PubMed Identifier: 23836213
author list: Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T
published in: Nature medicine
information resource reference: Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):809-10.
journal title abbreviation: Nat Med
publication date: 2013-07-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 533505
type: Authorship
author rank in publication: 2
linked author: Whitman, Malcolm
linked information resource: TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.

Dental Health Care for Special Needs Individuals: Trinidad and Tobago Summer Camp Case Study
end date: 2013-07-27T00:00:00
start date: 2013-06-24T00:00:00
type: Mentoring - Completed Student Project
overview: International/Summer

Authorship 688717
type: Authorship
author rank in publication: 1
linked author: Whitman, Malcolm
linked information resource: Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
PubMed Identifier: 23824657
author list: Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M
published in: American journal of medical genetics. Part A
information resource reference: A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A. 2013 Aug; 161A(8):2040-6.
journal title abbreviation: Am J Med Genet A
publication date: 2013-07-03T00:00:00
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type: Academic Article
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Authorship 336732
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author rank in publication: 4
linked author: Whitman, Malcolm
linked information resource: Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.

Teaching Associate in Obstetrics, Gynecology and Reproductive Biology
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HR job title: Teaching Associate in Obstetrics, Gynecology and Reproductive Biology
position in organization: Brigham and Women's Hospital

James Stillman Professor of Developmental Biology
is primary position: true
position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: James Stillman Professor of Developmental Biology
position in organization: Harvard Medical School

Instructor in Developmental Biology, Part-time
is primary position: true
position in department: Developmental Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Developmental Biology, Part-time
position in organization: Harvard School of Dental Medicine

Research Scientist in Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Scientist in Cell Biology
position in organization: Harvard Medical School

Professor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
is primary position: true
position in department: Stem Cell and Regenerative Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
position in organization: Harvard Medical School

Assistant Professor of Radiology
is primary position: true
position in department: Radiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Radiology
position in organization: Massachusetts General Hospital

Wyss Visiting Professor
is primary position: true
position in department: Wyss Institute
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Wyss Visiting Professor
position in organization: Harvard University

Authorship 754190
type: Authorship
author rank in publication: 15
linked author: Whitman, Malcolm
linked information resource: A secreted tyrosine kinase acts in the extracellular environment.

A secreted tyrosine kinase acts in the extracellular environment.
PubMed Identifier: 25171405
author list: Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M
published in: Cell
information resource reference: A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044.
journal title abbreviation: Cell
publication date: 2014-08-28T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 423963
type: Authorship
author rank in publication: 2
linked author: Whitman, Malcolm
linked information resource: Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.

Revollo, Leila
first name: Leila
last name: Revollo
full name: Leila Denise Revollo, Ph.D.
has faculty rank: Other Faculty
Person ID: 133175
person in primary position: Teaching Associate in Obstetrics, Gynecology and Reproductive Biology
type: Agent
type: Person
preferred title: Teaching Associate in Obstetrics, Gynecology and Reproductive Biology

Authorship 531691
type: Authorship
author rank in publication: 3
linked author: Whitman, Malcolm
linked information resource: Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction.

Authorship 94947
type: Authorship
author rank in publication: 5
linked author: Whitman, Malcolm
linked information resource: Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.

Authorship 475199
type: Authorship
author rank in publication: 2
linked author: Whitman, Malcolm
linked information resource: Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.

Authorship 795714
type: Authorship
author rank in publication: 21
linked author: Whitman, Malcolm
linked information resource: The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Authorship 795129
type: Authorship
author rank in publication: 5
linked author: Whitman, Malcolm
linked information resource: Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
PubMed Identifier: 25995223
author list: Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R
published in: Science translational medicine
information resource reference: The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20; 7(288):288ra77.
journal title abbreviation: Sci Transl Med
publication date: 2015-05-20T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
PubMed Identifier: 25975695
author list: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB
published in: Arthritis research & therapy
information resource reference: Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther. 2015 May 15; 17:126.
journal title abbreviation: Arthritis Res Ther
publication date: 2015-05-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 557510
type: Authorship
author rank in publication: 5
linked author: Whitman, Malcolm
linked information resource: Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.

Authorship 298003
type: Authorship
author rank in publication: 4
linked author: Whitman, Malcolm
linked information resource: Endogenous patterns of BMP signaling during early chick development.

Authorship 426646
type: Authorship
author rank in publication: 15
linked author: Whitman, Malcolm
linked information resource: Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

Authorship 454463
type: Authorship
author rank in publication: 3
linked author: Whitman, Malcolm
linked information resource: XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning.

Authorship 829706
type: Authorship
author rank in publication: 14
linked author: Whitman, Malcolm
linked information resource: A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.

Authorship 445977
type: Authorship
author rank in publication: 5
linked author: Whitman, Malcolm
linked information resource: TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.

Menthol Cigarettes and Tobacco Dependence in Elderly Nursing Home Residents
end date: 2010-08-13T00:00:00
start date: 2010-06-14T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Authorship 874503
type: Authorship
author rank in publication: 12
linked author: Whitman, Malcolm
linked information resource: Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.

Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
PubMed Identifier: 26787621
author list: Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S
published in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
information resource reference: Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model. J Heart Lung Transplant. 2016 Apr; 35(4):518-27.
journal title abbreviation: J Heart Lung Transplant
publication date: 2015-12-10T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Breast Cancer Bone Metastasis: RANKL signalling and MMP-2 mediated invasion
end date: 2007-08-17T00:00:00
start date: 2007-06-11T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Authorship 6163
type: Authorship
author rank in publication: 5
linked author: Whitman, Malcolm
linked information resource: Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction.

Authorship 560613
type: Authorship
author rank in publication: 3
linked author: Whitman, Malcolm
linked information resource: Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.

Assistant Professor
sort order: 2
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 52398
type: Authorship
author rank in publication: 7
linked author: Whitman, Malcolm
linked information resource: Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron.

Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM
end date: 2012-08-31
principal investigator name: WHITMAN, MALCOLM R.
start date: 1992-08-05
type: Grant
sponsor award id: R01HD029468

SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYO DEVELOPMENT
end date: 2004-11-30
principal investigator name: STILES, CHARLES
start date: 1989-09-01
type: Grant
sponsor award id: P01HD024926

Role of the first secreted tyrosine kinase in bone development, homeostasis, and repair.
end date: 2020-03-31
principal investigator name: WHITMAN, MALCOLM R.
start date: 2015-04-01
type: Grant
sponsor award id: R01AR066717

MECHANISM OF ACTION OF HALOFUGINONE AS A NOVEL THERAPEUTIC
end date: 2015-02-28
principal investigator name: WHITMAN, MALCOLM R.
start date: 2010-04-01
type: Grant
sponsor award id: R01GM089885

Role of a Novel Secreted Protein Tyrosine Kinase in Development
end date: 2017-03-31
principal investigator name: WHITMAN, MALCOLM R.
start date: 2014-04-09
type: Grant
sponsor award id: R21DE024312

The first secreted Tyrosine kinase
end date: 2020-08-31
principal investigator name: WHITMAN, MALCOLM R.
start date: 2015-09-17
type: Grant
sponsor award id: R01GM115417

Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: MECHANISM OF ACTION OF HALOFUGINONE AS A NOVEL THERAPEUTIC

Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: The first secreted Tyrosine kinase

Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: Regulation of Xenopus Embryonic Development by TGFbeta Superfamily Ligands and SM

Co-Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: Role of the first secreted tyrosine kinase in bone development, homeostasis, and repair.

Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: Role of a Novel Secreted Protein Tyrosine Kinase in Development

Co-Principal Investigator
type: Researcher Role
researcher role of: Whitman, Malcolm
contributes to: SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYO DEVELOPMENT

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.
PubMed Identifier: 12414726
author list: Oh SP, Yeo CY, Lee Y, Schrewe H, Whitman M, Li E
published in: Genes & development
information resource reference: Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev. 2002 Nov 01; 16(21):2749-54.
journal title abbreviation: Genes Dev
publication date: 2002-11-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.
PubMed Identifier: 19498172
author list: Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A
published in: Science (New York, N.Y.)
information resource reference: Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009 Jun 05; 324(5932):1334-8.
journal title abbreviation: Science
publication date: 2009-06-05T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction.
PubMed Identifier: 14522874
author list: Kunwar PS, Zimmerman S, Bennett JT, Chen Y, Whitman M, Schier AF
published in: Development (Cambridge, England)
information resource reference: Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction. Development. 2003 Dec; 130(23):5589-99.
journal title abbreviation: Development
publication date: 2003-10-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron.
PubMed Identifier: 12454922
author list: Watanabe M, Rebbert ML, Andreazzoli M, Takahashi N, Toyama R, Zimmerman S, Whitman M, Dawid IB
published in: Developmental dynamics : an official publication of the American Association of Anatomists
information resource reference: Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Dev Dyn. 2002 Dec; 225(4):448-56.
journal title abbreviation: Dev Dyn
publication date: 2002-12-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled.
PubMed Identifier: 16193491
author list: Onuma Y, Takahashi S, Haramoto Y, Tanegashima K, Yokota C, Whitman M, Asashima M
published in: Developmental dynamics : an official publication of the American Association of Anatomists
information resource reference: Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled. Dev Dyn. 2005 Dec; 234(4):900-10.
journal title abbreviation: Dev Dyn
publication date: 2005-12-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
PubMed Identifier: 16684517
author list: Ho DM, Chan J, Bayliss P, Whitman M
published in: Developmental biology
information resource reference: Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Dev Biol. 2006 Jul 15; 295(2):730-42.
journal title abbreviation: Dev Biol
publication date: 2006-05-08T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.
PubMed Identifier: 11389842
author list: Yeo C, Whitman M
published in: Molecular cell
information resource reference: Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell. 2001 May; 7(5):949-57.
journal title abbreviation: Mol Cell
publication date: 2001-05-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Endogenous patterns of BMP signaling during early chick development.
PubMed Identifier: 11900458
author list: Faure S, de Santa Barbara P, Roberts DJ, Whitman M
published in: Developmental biology
information resource reference: Endogenous patterns of BMP signaling during early chick development. Dev Biol. 2002 Apr 01; 244(1):44-65.
journal title abbreviation: Dev Biol
publication date: 2002-04-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

New roles for FoxH1 in patterning the early embryo.
PubMed Identifier: 15459100
author list: Kofron M, Puck H, Standley H, Wylie C, Old R, Whitman M, Heasman J
published in: Development (Cambridge, England)
information resource reference: New roles for FoxH1 in patterning the early embryo. Development. 2004 Oct; 131(20):5065-78.
journal title abbreviation: Development
publication date: 2004-10-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

p53 and TGF-beta in development: prelude to tumor suppression?
PubMed Identifier: 12732134
author list: Whitman M, McKeon F
published in: Cell
information resource reference: p53 and TGF-beta in development: prelude to tumor suppression? Cell. 2003 May 02; 113(3):275-6.
journal title abbreviation: Cell
publication date: 2003-05-02T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos.
PubMed Identifier: 16797167
author list: Onuma Y, Asashima M, Whitman M
published in: Mechanisms of development
information resource reference: A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos. Mech Dev. 2006 Jun; 123(6):463-71.
journal title abbreviation: Mech Dev
publication date: 2006-05-05T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

TGFbeta signaling at the summit.
PubMed Identifier: 16155212
author list: Whitman M, Raftery L
published in: Development (Cambridge, England)
information resource reference: TGFbeta signaling at the summit. Development. 2005 Oct; 132(19):4205-10.
journal title abbreviation: Development
publication date: 2005-10-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
PubMed Identifier: 22493429
author list: Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Iñiguez-Lluhí JA
published in: The Journal of biological chemistry
information resource reference: Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2. J Biol Chem. 2012 May 25; 287(22):18318-29.
journal title abbreviation: J Biol Chem
publication date: 2012-04-05T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.
PubMed Identifier: 21974968
author list: Kamberov YG, Kim J, Mazitschek R, Kuo WP, Whitman M
published in: BMC research notes
information resource reference: Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells. BMC Res Notes. 2011 Oct 05; 4:381.
journal title abbreviation: BMC Res Notes
publication date: 2011-10-05T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Smad4 and FAST-1 in the assembly of activin-responsive factor.
PubMed Identifier: 9288972
author list: Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M
published in: Nature
information resource reference: Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature. 1997 Sep 04; 389(6646):85-9.
journal title abbreviation: Nature
publication date: 1997-09-04T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Smads and early developmental signaling by the TGFbeta superfamily.
PubMed Identifier: 9716398
author list: Whitman M
published in: Genes & development
information resource reference: Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev. 1998 Aug 15; 12(16):2445-62.
journal title abbreviation: Genes Dev
publication date: 1998-08-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning.
PubMed Identifier: 16339189
author list: Onuma Y, Yeo CY, Whitman M
published in: Development (Cambridge, England)
information resource reference: XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning. Development. 2006 Jan; 133(2):237-50.
journal title abbreviation: Development
publication date: 2005-12-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.
PubMed Identifier: 18175804
author list: Anderson SB, Goldberg AL, Whitman M
published in: The Journal of biological chemistry
information resource reference: Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem. 2008 Mar 14; 283(11):7027-35.
journal title abbreviation: J Biol Chem
publication date: 2008-01-06T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
PubMed Identifier: 22327401
author list: Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M
published in: Nature chemical biology
information resource reference: Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12; 8(3):311-7.
journal title abbreviation: Nat Chem Biol
publication date: 2012-02-12T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

A transcriptional partner for MAD proteins in TGF-beta signalling.
PubMed Identifier: 8878477
author list: Chen X, Rubock MJ, Whitman M
published in: Nature
information resource reference: A transcriptional partner for MAD proteins in TGF-beta signalling. Nature. 1996 Oct 24; 383(6602):691-6.
journal title abbreviation: Nature
publication date: 1996-10-24T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Harvard Dental Center
type: Division
type: Organization

TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.
PubMed Identifier: 18828657
author list: Onuma Y, Watanabe A, Aburatani H, Asashima M, Whitman M
published in: Zoological science
information resource reference: TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates. Zoolog Sci. 2008 Jul; 25(7):706-13.
journal title abbreviation: Zoolog Sci
publication date: 2008-07-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

188 Longwood Ave
type: Address
address line 1: Harvard School of Dental Medicine
address line 2: REB 505
address line 3: 188 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.
PubMed Identifier: 20807570
author list: Ho DM, Yeo CY, Whitman M
published in: Mechanisms of development
information resource reference: The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo. Mech Dev. 2010 Sep-Dec; 127(9-12):485-95.
journal title abbreviation: Mech Dev
publication date: 2010-08-31T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.
PubMed Identifier: 19950203
author list: Danciu TE, Whitman M
published in: Journal of cellular biochemistry
information resource reference: Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors. J Cell Biochem. 2010 Feb 01; 109(2):417-24.
journal title abbreviation: J Cell Biochem
publication date: 2010-02-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction.
PubMed Identifier: 15617685
author list: Wawersik S, Evola C, Whitman M
published in: Developmental biology
information resource reference: Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction. Dev Biol. 2005 Jan 15; 277(2):425-42.
journal title abbreviation: Dev Biol
publication date: 2005-01-15T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource