Kaye, Kenneth
eCommons Login: KMK3
first name: Kenneth
last name: Kaye
coauthor of: Hatabu, Hiroto
coauthor of: Gong, Jingyi
coauthor of: Christiani, David
coauthor of: Zhao, Bo
coauthor of: Tumuluri, Vinayak
full name: Kenneth Marc Kaye, M.D.
has faculty rank: Full Professor
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Person ID: 15873
person in primary position: Professor of Medicine
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similar to: Knipe, David
similar to: Xia, Ning
similar to: Gewurz, Benjamin
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type: Agent
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selected publications: Authorship 1733613
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selected publications: Authorship 647372
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selected publications: Authorship 240074
selected publications: Authorship 167098
selected publications: Authorship 422534
selected publications: Authorship 248353
selected publications: Authorship 367788
selected publications: Authorship 471746
selected publications: Authorship 121673
selected publications: Authorship 279414
selected publications: Authorship 44837
selected publications: Authorship 359372
selected publications: Authorship 269334
selected publications: Authorship 2903

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Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature.
PubMed Identifier: 1600002
author list: Kaye KM, Macone A, Kazanjian PH
published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
information resource reference: Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature. Clin Infect Dis. 1992 May; 14(5):1010-4.
journal title abbreviation: Clin Infect Dis
publication date: 1992-05-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.
PubMed Identifier: 16721045
author list: Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Luger K, Kaye KM
published in: Cell cycle (Georgetown, Tex.)
information resource reference: Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome. Cell Cycle. 2006 May; 5(10):1048-52.
journal title abbreviation: Cell Cycle
publication date: 2006-05-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/1018095
PubMed Identifier: 17329344
author list: Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C
published in: Journal of virology
information resource reference: Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May; 81(9):4904-8.
journal title abbreviation: J Virol
publication date: 2007-02-28T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

https://connects.catalyst.harvard.edu/Profiles/profile/1036197
PubMed Identifier: 8207810
author list: Izumi KM, Kaye KM, Kieff ED
published in: Journal of virology
information resource reference: Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation. J Virol. 1994 Jul; 68(7):4369-76.
journal title abbreviation: J Virol
publication date: 1994-07-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation.

Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.
PubMed Identifier: 8415670
author list: Kaye KM, Izumi KM, Kieff E
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9150-4.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-10-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test.
PubMed Identifier: 2523637
author list: Kaye KM, McKusick KA, Eagle KA
published in: American heart journal
information resource reference: Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test. Am Heart J. 1989 May; 117(5):1169-71.
journal title abbreviation: Am Heart J
publication date: 1989-05-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).
PubMed Identifier: 3012122
author list: Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL
published in: Journal of virology
information resource reference: Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol. 1986 Jul; 59(1):90-7.
journal title abbreviation: J Virol
publication date: 1986-07-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Xia, Ning
eCommons Login: NX7
first name: Ning
last name: Xia
full name: Ning Xia, M.D., Ph.D.
has faculty rank: Instructor
Person ID: 170624
person in primary position: Instructor in Neurology
type: Agent
type: Person
preferred title: Instructor in Neurology

The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.
PubMed Identifier: 22122438
author list: Ballestas ME, Kaye KM
published in: Future microbiology
information resource reference: The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiol. 2011 Dec; 6(12):1399-413.
journal title abbreviation: Future Microbiol
publication date: 2011-12-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 108313
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.

Authorship 11503
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen.

Topical antibacterial agents.
PubMed Identifier: 7490432
author list: Kaye ET, Kaye KM
published in: Infectious disease clinics of North America
information resource reference: Topical antibacterial agents. Infect Dis Clin North Am. 1995 Sep; 9(3):547-59.
journal title abbreviation: Infect Dis Clin North Am
publication date: 1995-09-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

KSHV LANA's expanding bag of tricks.
PubMed Identifier: 18441240
author list: Barbera AJ, Kaye KM
published in: Blood
information resource reference: KSHV LANA's expanding bag of tricks. Blood. 2008 May 01; 111(9):4425-6.
journal title abbreviation: Blood
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1087952
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4.

In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4.
PubMed Identifier: 30111565
author list: Pires de Miranda M, Quendera AP, McVey CE, Kaye KM, Simas JP
published in: Journal of virology
information resource reference: In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4. J Virol. 2018 11 01; 92(21).
journal title abbreviation: J Virol
publication date: 2018-10-12T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence.
PubMed Identifier: 21593163
author list: De León Vázquez E, Kaye KM
published in: Journal of virology
information resource reference: The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence. J Virol. 2011 Aug; 85(15):7622-33.
journal title abbreviation: J Virol
publication date: 2011-05-18T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.
PubMed Identifier: 21679790
author list: Bazan JA, Martin SI, Kaye KM
published in: The Medical clinics of North America
information resource reference: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Med Clin North Am. 2011 Jul; 95(4):743-60, viii.
journal title abbreviation: Med Clin North Am
publication date: 2011-07-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.
PubMed Identifier: 22915819
author list: Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM
published in: Journal of virology
information resource reference: Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence. J Virol. 2012 Nov; 86(21):11863-76.
journal title abbreviation: J Virol
publication date: 2012-08-22T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.
PubMed Identifier: 16940503
author list: You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM
published in: Journal of virology
information resource reference: Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19.
journal title abbreviation: J Virol
publication date: 2006-09-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapid and quantitative assessment of KSHV LANA-mediated DNA replication.
PubMed Identifier: 21472413
author list: De León Vázquez E, Kaye KM
published in: Archives of virology
information resource reference: Rapid and quantitative assessment of KSHV LANA-mediated DNA replication. Arch Virol. 2011 Aug; 156(8):1323-33.
journal title abbreviation: Arch Virol
publication date: 2011-04-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

The newer macrolides. Azithromycin and clarithromycin.
PubMed Identifier: 7490441
author list: Zuckerman JM, Kaye KM
published in: Infectious disease clinics of North America
information resource reference: The newer macrolides. Azithromycin and clarithromycin. Infect Dis Clin North Am. 1995 Sep; 9(3):731-45.
journal title abbreviation: Infect Dis Clin North Am
publication date: 1995-09-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Microbiology
type: Department
type: Organization

Authorship 1124549
type: Authorship
author rank in publication: 5
linked author: Kaye, Kenneth
linked information resource: Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance.

Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance.
PubMed Identifier: 30626680
author list: Juillard F, De León Vázquez E, Tan M, Li S, Kaye KM
published in: Journal of virology
information resource reference: Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance. J Virol. 2019 03 15; 93(6).
journal title abbreviation: J Virol
publication date: 2019-03-05T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.
PubMed Identifier: 7815530
author list: Kaye KM, Izumi KM, Mosialos G, Kieff E
published in: Journal of virology
information resource reference: The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J Virol. 1995 Feb; 69(2):675-83.
journal title abbreviation: J Virol
publication date: 1995-02-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 127312
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.

Authorship 1138138
type: Authorship
author rank in publication: 8
linked author: Kaye, Kenneth
linked information resource: NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.

NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
PubMed Identifier: 30811506
author list: Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K
published in: PLoS pathogens
information resource reference: NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 02; 15(2):e1007628.
journal title abbreviation: PLoS Pathog
publication date: 2019-02-27T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Virus Latency
MeSH DescriptorUI: D017735
MeSH semantic group name: Physiology
number of authors: 140
number of publications: 384
uniqueness weight: 0.779965
type: Concept

Antigens, Viral
MeSH DescriptorUI: D000956
MeSH semantic group name: Chemicals & Drugs
number of authors: 433
number of publications: 1021
uniqueness weight: 0.716311
type: Concept

Nuclear Proteins
MeSH DescriptorUI: D009687
MeSH semantic group name: Chemicals & Drugs
number of authors: 1825
number of publications: 5899
uniqueness weight: 0.347404
type: Concept

Herpesvirus 8, Human
MeSH DescriptorUI: D019288
MeSH semantic group name: Living Beings
number of authors: 108
number of publications: 251
uniqueness weight: 0.855757
type: Concept

Sarcoma, Kaposi
MeSH DescriptorUI: D012514
MeSH semantic group name: Disorders
number of authors: 168
number of publications: 377
uniqueness weight: 0.770644
type: Concept

Emeritus
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Environmental Health
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Epidemiology
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Medicine
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Neurology
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Cardiology
type: Division
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Infectious Disease
type: Division
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Brigham and Women's Hospital
type: Organization

Boston Children's Hospital
type: Organization

Harvard Medical School
type: Organization

Harvard T.H. Chan School of Public Health
type: Organization

Massachusetts General Hospital
type: Organization

Christiani, David
eCommons Login: DCC5
first name: David
last name: Christiani
full name: David Christopher Christiani, M.D.
has faculty rank: Full Professor
latitude: 42.33570000000000
longitude: -71.10169990000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 14998
person in primary position: Elkan Blout Professor of Environmental Genetics
type: Agent
type: Person
preferred title: Elkan Blout Professor of Environmental Genetics

Knipe, David
eCommons Login: DMK2
first name: David
last name: Knipe
full name: David Mahan Knipe, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 32973
person in primary position: Higgins Professor of Microbiology and Molecular Genetics
type: Agent
type: Person
preferred title: Higgins Professor of Microbiology and Molecular Genetics

Hatabu, Hiroto
eCommons Login: HH12
first name: Hiroto
last name: Hatabu
full name: Hiroto Hatabu, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 77637
person in primary position: Professor of Radiology, Emeritus
type: Agent
type: Person
preferred title: Professor of Radiology, Emeritus

Issa, Nicolas
eCommons Login: NCI2
first name: Nicolas
last name: Issa
full name: Nicolas Chafic Issa, M.D.
has faculty rank: Assistant Professor
latitude: 42.33669100000000
longitude: -71.10208900000000
Person ID: 74898
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Zhao, Bo
eCommons Login: BZ3
first name: Bo
last name: Zhao
full name: Bo Zhao, Ph.D.
has faculty rank: Associate Professor
latitude: 42.33669100000000
longitude: -71.10208900000000
Person ID: 81621
person in primary position: Associate Professor of Medicine
type: Agent
type: Person
preferred title: Associate Professor of Medicine

Coen, Donald
eCommons Login: DMC2
first name: Donald
last name: Coen
full name: Donald Mark Coen, Ph.D.
has faculty rank: Full Professor
latitude: 42.33738860000000
longitude: -71.10437290000000
Person ID: 22117
person in primary position: Professor of Biological Chemistry and Molecular Pharmacology
type: Agent
type: Person
preferred title: Professor of Biological Chemistry and Molecular Pharmacology

Bond, Sheila
eCommons Login: SFM5
first name: Sheila
last name: Bond
full name: Sheila Filan Bond, M.D.
has faculty rank: Instructor
latitude: 42.33669100000000
longitude: -71.10208900000000
Person ID: 21969
person in primary position: Instructor in Medicine, Part-time
type: Agent
type: Person
preferred title: Instructor in Medicine, Part-time

Waldor, Matthew
eCommons Login: MKW5
first name: Matthew
last name: Waldor
full name: Matthew K Waldor, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.33669100000000
longitude: -71.10208900000000
Person ID: 21400
person in primary position: Edward H. Kass Professor of Medicine
type: Agent
type: Person
preferred title: Edward H. Kass Professor of Medicine

Gewurz, Benjamin
eCommons Login: BEG1
first name: Benjamin
last name: Gewurz
full name: Benjamin Elison Gewurz, M.D.,Ph.D.
has faculty rank: Associate Professor
latitude: 42.33669100000000
longitude: -71.10208900000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 40461
person in primary position: George and Sandra K. Schussel Associate Professor of Medicine in the Field of Infectious Diseases
type: Agent
type: Person
preferred title: George and Sandra K. Schussel Associate Professor of Medicine in the Field of Infectious Diseases

Kasper, Dennis
eCommons Login: DLK1
first name: Dennis
last name: Kasper
full name: Dennis Lee Kasper, M.D.
has faculty rank: Full Professor
latitude: 42.33669100000000
longitude: -71.10208900000000
Person ID: 72879
person in primary position: William Ellery Channing Professor of Medicine
type: Agent
type: Person
preferred title: William Ellery Channing Professor of Medicine

selected publications
maximum weight: 1
minimum weight: 1
number of connections: 78
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Gong, Jingyi
eCommons Login: JG245
first name: Jingyi
last name: Gong
full name: Jingyi Gong, M.D.
has faculty rank: Fellow or Post Doc
Person ID: 127291
person in primary position: Clinical Fellow in Medicine
type: Agent
type: Person
preferred title: Clinical Fellow in Medicine

Authorship 1194311
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease.

Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease.
PubMed Identifier: 31570344
author list: Gong J, Meyerowitz EA, Isidro RA, Kaye KM
published in: BMJ case reports
information resource reference: Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease. BMJ Case Rep. 2019 Sep 30; 12(9).
journal title abbreviation: BMJ Case Rep
publication date: 2019-09-30T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor in Medicine, Part-time
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Instructor in Medicine, Part-time
position in organization: Brigham and Women's Hospital

Authorship 121673
type: Authorship
author rank in publication: 5
linked author: Kaye, Kenneth
linked information resource: Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.

Authorship 1227019
type: Authorship
author rank in publication: 12
linked author: Kaye, Kenneth
linked information resource: ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome.

ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome.
PubMed Identifier: 32068070
author list: Slevin MK, Wollison BM, Powers W, Burns RT, Patel N, Ducar MD, Starrett GJ, Garcia EP, Manning DK, Cheng J, Hanna GJ, Kaye KM, Van Hummelen P, Nag A, Thorner AR, DeCaprio JA, MacConaill LE
published in: The Journal of molecular diagnostics : JMD
information resource reference: ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487.
journal title abbreviation: J Mol Diagn
publication date: 2020-02-15T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 167098
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.

Genetic and Biochemical Studies of KSHV LANA
end date: 2025-03-31
principal investigator name: KAYE, KENNETH M
start date: 2020-04-01
type: Grant
sponsor award id: R01AI150575

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: Genetic and Biochemical Studies of KSHV LANA

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 204853
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: The newer macrolides. Azithromycin and clarithromycin.

Authorship 1275919
type: Authorship
author rank in publication: 10
linked author: Kaye, Kenneth
linked information resource: KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence.

KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence.
PubMed Identifier: 32820070
author list: Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, Liu B, Álvarez ÁL, Tan M, Szymula A, Kaye KM, Simas JP
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22443-22451.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-08-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

BCMP
type: Department
type: Organization

Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors.
PubMed Identifier: 33298918
author list: Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, Narita Y, Hou I, Liang J, Li S, Xiao H, Gottwein E, Kaye KM, Teng M, Zhao B
published in: Nature communications
information resource reference: Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors. Nat Commun. 2020 12 09; 11(1):6318.
journal title abbreviation: Nat Commun
publication date: 2020-12-09T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1312454
type: Authorship
author rank in publication: 13
linked author: Kaye, Kenneth
linked information resource: Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors.

Authorship 166703
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.

Authorship 1413255
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2.

Authorship 1414947
type: Authorship
author rank in publication: 15
linked author: Kaye, Kenneth
linked information resource: MLL1 is regulated by KSHV LANA and is important for virus latency.

Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2.
PubMed Identifier: 34725152
author list: Lee SM, Kaye KM, Slack FJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2. Proc Natl Acad Sci U S A. 2021 11 09; 118(45).
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2021-11-09T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

MLL1 is regulated by KSHV LANA and is important for virus latency.
PubMed Identifier: 34850113
author list: Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM
published in: Nucleic acids research
information resource reference: MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 2021 12 16; 49(22):12895-12911.
journal title abbreviation: Nucleic Acids Res
publication date: 2021-12-16T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/190974734
type: URLLink
label: https://kayelab.bwh.harvard.edu/
link anchor text: Link to Kaye laboratory website

Authorship 348760
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature.

Authorship 1504215
type: Authorship
author rank in publication: 14
linked author: Kaye, Kenneth
linked information resource: COVID-19 Vaccination reduced pneumonia severity.

COVID-19 Vaccination reduced pneumonia severity.
PubMed Identifier: 36386765
author list: Wada N, Li Y, Hino T, Gagne S, Valtchinov VI, Gay E, Nishino M, Madore B, Guttmann CRG, Bond S, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
published in: European journal of radiology open
information resource reference: COVID-19 Vaccination reduced pneumonia severity. Eur J Radiol Open. 2022; 9:100456.
journal title abbreviation: Eur J Radiol Open
publication date: 2022-11-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1509202
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Viral Infection, Pulmonary Fibrosis, and Long COVID.

Viral Infection, Pulmonary Fibrosis, and Long COVID.
PubMed Identifier: 36470237
author list: Hatabu H, Kaye KM, Christiani DC
published in: American journal of respiratory and critical care medicine
information resource reference: Viral Infection, Pulmonary Fibrosis, and Long COVID. Am J Respir Crit Care Med. 2023 03 15; 207(6):647-649.
journal title abbreviation: Am J Respir Crit Care Med
publication date: 2023-03-15T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 202035
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.

Authorship 1521923
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Reply to Kamp et al.: Novel Insight into Pulmonary Fibrosis and Long Covid.

Reply to Kamp et al.: Novel Insight into Pulmonary Fibrosis and Long Covid.
PubMed Identifier: 36731064
author list: Hatabu H, Kaye KM, Christiani DC
published in: American journal of respiratory and critical care medicine
information resource reference: Reply to Kamp et al.: Novel Insight into Pulmonary Fibrosis and Long Covid. Am J Respir Crit Care Med. 2023 04 15; 207(8):1108.
journal title abbreviation: Am J Respir Crit Care Med
publication date: 2023-04-15T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Tumuluri, Vinayak
eCommons Login: vit949
first name: Vinayak
last name: Tumuluri
full name: Vinayak Sadasivam Tumuluri, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 211943
person in primary position: Research Fellow in Biological Chemistry and Molecular Pharmacology
type: Agent
type: Person
preferred title: Research Fellow in Biological Chemistry and Molecular Pharmacology

Authorship 1532123
type: Authorship
author rank in publication: 15
linked author: Kaye, Kenneth
linked information resource: Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans.

Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans.
PubMed Identifier: 36883046
author list: Hino T, Nishino M, Valtchinov VI, Gagne S, Gay E, Wada N, Tseng SC, Madore B, Guttmann CRG, Ishigami K, Li Y, Christiani DC, Hunninghake GM, Levy BD, Kaye KM, Hatabu H
published in: European journal of radiology open
information resource reference: Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans. Eur J Radiol Open. 2023; 10:100483.
journal title abbreviation: Eur J Radiol Open
publication date: 2023-03-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 256024
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.

Authorship 1556546
type: Authorship
author rank in publication: 10
linked author: Kaye, Kenneth
linked information resource: Macrophages drive KSHV B cell latency.

Macrophages drive KSHV B cell latency.
PubMed Identifier: 37440412
author list: Szymula A, Samayoa-Reyes G, Ogolla S, Liu B, Li S, George A, Van Sciver N, Rochford R, Simas JP, Kaye KM
published in: Cell reports
information resource reference: Macrophages drive KSHV B cell latency. Cell Rep. 2023 07 25; 42(7):112767.
journal title abbreviation: Cell Rep
publication date: 2023-07-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 359019
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter.

Authorship 1609208
type: Authorship
author rank in publication: 14
linked author: Kaye, Kenneth
linked information resource: Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants.

Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants.
PubMed Identifier: 38050198
author list: Wada N, Li Y, Gagne S, Hino T, Valtchinov VI, Gay E, Nishino M, Hammer MM, Madore B, Guttmann CRG, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
published in: Medicine
information resource reference: Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants. Medicine (Baltimore). 2023 Dec 01; 102(48):e36417.
journal title abbreviation: Medicine (Baltimore)
publication date: 2023-12-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1618821
type: Authorship
author rank in publication: 14
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome.

Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome.
PubMed Identifier: 38180827
author list: Li S, Liu B, Tan M, Juillard F, Szymula A, Álvarez ÁL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM
published in: Nucleic acids research
information resource reference: Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Nucleic Acids Res. 2024 Feb 28; 52(4):1814-1829.
journal title abbreviation: Nucleic Acids Res
publication date: 2024-02-28T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1621565
type: Authorship
author rank in publication: 13
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.

Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
PubMed Identifier: 38232124
author list: Li S, Wang M, Van Sciver N, Szymula A, Tumuluri VS, George A, Ramachandran A, Raina K, Costa CN, Zhao B, Kazemian M, Simas JP, Kaye KM
published in: PLoS pathogens
information resource reference: Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection. PLoS Pathog. 2024 Jan; 20(1):e1011907.
journal title abbreviation: PLoS Pathog
publication date: 2024-01-17T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

William Ellery Channing Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: William Ellery Channing Professor of Medicine
position in organization: Brigham and Women's Hospital

KSHV Latency Regulation
end date: 2026-10-31
principal investigator name: KAYE, KENNETH M
start date: 2021-11-05
type: Grant
sponsor award id: R01AI165382

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: KSHV Latency Regulation

Clinical Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Cardiology
sort order: 1
type: Position
HR job title: Clinical Fellow in Medicine
position in organization: Massachusetts General Hospital

Professor of Biological Chemistry and Molecular Pharmacology
is primary position: true
position in department: BCMP
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Biological Chemistry and Molecular Pharmacology
position in organization: Harvard Medical School

Instructor in Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Neurology
position in organization: Massachusetts General Hospital

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Brigham and Women's Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 647372
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation.

Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation.
PubMed Identifier: 23950719
author list: Rodrigues L, Popov N, Kaye KM, Simas JP
published in: PLoS pathogens
information resource reference: Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation. PLoS Pathog. 2013; 9(8):e1003554.
journal title abbreviation: PLoS Pathog
publication date: 2013-08-08T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 525157
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient.

Authorship 192468
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).

Authorship 679308
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence.

Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence.
PubMed Identifier: 24006437
author list: Vázquez Ede L, Carey VJ, Kaye KM
published in: Journal of virology
information resource reference: Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence. J Virol. 2013 Nov; 87(22):12270-83.
journal title abbreviation: J Virol
publication date: 2013-09-04T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 681363
type: Authorship
author rank in publication: 10
linked author: Kaye, Kenneth
linked information resource: Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.

Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.
PubMed Identifier: 24146618
author list: Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE
published in: PLoS pathogens
information resource reference: Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. PLoS Pathog. 2013; 9(10):e1003673.
journal title abbreviation: PLoS Pathog
publication date: 2013-10-17T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

KSHV Infection And Persistence
end date: 2030-03-31
principal investigator name: KAYE, KENNETH M
start date: 2025-04-10
type: Grant
sponsor award id: R01AI189319

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: KSHV Infection And Persistence

Authorship 1733613
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.

Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.
PubMed Identifier: 39896566
author list: Lee SM, Avalos CL, Miliotis C, Doh HM, Chan E, Kaye KM, Slack FJ
published in: bioRxiv : the preprint server for biology
information resource reference: Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression. bioRxiv. 2025 Jan 24.
journal title abbreviation: bioRxiv
publication date: 2025-01-24T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Radiology, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Radiology, Emeritus
position in organization: Harvard Medical School

Authorship 697580
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence.

A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence.
PubMed Identifier: 24314665
author list: De León Vázquez E, Juillard F, Rosner B, Kaye KM
published in: Virology
information resource reference: A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence. Virology. 2014 Jan 05; 448:344-55.
journal title abbreviation: Virology
publication date: 2013-11-12T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 184607
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors.

Higgins Professor of Microbiology and Molecular Genetics
is primary position: true
position in department: Microbiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Higgins Professor of Microbiology and Molecular Genetics
position in organization: Harvard Medical School

George and Sandra K. Schussel Associate Professor of Medicine in the Field of Infectious Diseases
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: George and Sandra K. Schussel Associate Professor of Medicine in the Field of Infectious Diseases
position in organization: Brigham and Women's Hospital

Authorship 2903
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes.

Authorship 279414
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: KSHV LANA's expanding bag of tricks.

Authorship 240074
type: Authorship
author rank in publication: 5
linked author: Kaye, Kenneth
linked information resource: Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.

Authorship 330133
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Topical antibacterial agents.

Adjunct Professor of Epidemiology and Infectious Diseases
is primary position: true
position in department: Epidemiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Adjunct Professor of Epidemiology and Infectious Diseases
position in organization: Harvard T.H. Chan School of Public Health

Edward H. Kass Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Edward H. Kass Professor of Medicine
position in organization: Brigham and Women's Hospital

Elkan Blout Professor of Environmental Genetics
is primary position: true
position in department: Environmental Health
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Elkan Blout Professor of Environmental Genetics
position in organization: Harvard T.H. Chan School of Public Health

Research Fellow in Biological Chemistry and Molecular Pharmacology
is primary position: true
position in department: BCMP
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Fellow in Biological Chemistry and Molecular Pharmacology
position in organization: Boston Children's Hospital

Authorship 751200
type: Authorship
author rank in publication: 8
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.

Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.
PubMed Identifier: 25071216
author list: Sun Q, Tsurimoto T, Juillard F, Li L, Li S, De León Vázquez E, Chen S, Kaye K
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):11816-21.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2014-07-28T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 530232
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.

Authorship 546495
type: Authorship
author rank in publication: 7
linked author: Kaye, Kenneth
linked information resource: The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.

Authorship 93815
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence.

Authorship 422534
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

Authorship 359372
type: Authorship
author rank in publication: 14
linked author: Kaye, Kenneth
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1018095

Authorship 505939
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation.

Authorship 523912
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1036197

Authorship 53611
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test.

Authorship 181751
type: Authorship
author rank in publication: 5
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.

Authorship 550840
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: The KSHV latency-associated nuclear antigen: a multifunctional protein.

Authorship 106715
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA.

Authorship 240440
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.

Authorship 356277
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability.

Authorship 29575
type: Authorship
author rank in publication: 5
linked author: Kaye, Kenneth
linked information resource: KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence.

Authorship 269334
type: Authorship
author rank in publication: 8
linked author: Kaye, Kenneth
linked information resource: Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding.

Authorship 248353
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence.

Authorship 367788
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Rapid and quantitative assessment of KSHV LANA-mediated DNA replication.

Authorship 550978
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.

Authorship 793702
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68.

Authorship 792487
type: Authorship
author rank in publication: 10
linked author: Kaye, Kenneth
linked information resource: Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva.

Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva.
PubMed Identifier: 26046668
author list: Shafiee H, Kanakasabapathy MK, Juillard F, Keser M, Sadasivam M, Yuksekkaya M, Hanhauser E, Henrich TJ, Kuritzkes DR, Kaye KM, Demirci U
published in: Scientific reports
information resource reference: Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva. Sci Rep. 2015 Jun 05; 5:9919.
journal title abbreviation: Sci Rep
publication date: 2015-06-05T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68.
PubMed Identifier: 25662997
author list: Hu Z, Blackman MA, Kaye KM, Usherwood EJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68. J Immunol. 2015 Mar 15; 194(6):2746-56.
journal title abbreviation: J Immunol
publication date: 2015-02-06T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 429675
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.

Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics.
PubMed Identifier: 26195743
author list: Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-07-20T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 823617
type: Authorship
author rank in publication: 25
linked author: Kaye, Kenneth
linked information resource: Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics.

Authorship 44837
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: A charged and contoured surface on the nucleosome regulates chromatin compaction.

Authorship 468629
type: Authorship
author rank in publication: 1
linked author: Kaye, Kenneth
linked information resource: The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.

Authorship 471746
type: Authorship
author rank in publication: 3
linked author: Kaye, Kenneth
linked information resource: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

Authorship 849854
type: Authorship
author rank in publication: 9
linked author: Kaye, Kenneth
linked information resource: The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.

Authorship 849952
type: Authorship
author rank in publication: 10
linked author: Kaye, Kenneth
linked information resource: KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.

The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.
PubMed Identifier: 26420481
author list: Li S, Tan M, Juillard F, Ponnusamy R, Correia B, Simas JP, Carrondo MA, McVey CE, Kaye KM
published in: The Journal of biological chemistry
information resource reference: The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence. J Biol Chem. 2015 Nov 20; 290(47):28084-28096.
journal title abbreviation: J Biol Chem
publication date: 2015-09-29T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
PubMed Identifier: 26424851
author list: Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE
published in: Nucleic acids research
information resource reference: KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. Nucleic Acids Res. 2015 Nov 16; 43(20):10039-54.
journal title abbreviation: Nucleic Acids Res
publication date: 2015-09-30T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 869100
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus.

Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus.
PubMed Identifier: 26851580
author list: Safavieh M, Khetani S, Juillard F, Kaul V, Kanakasabapathy MK, Kaye KM, Shafiee H
published in: Biosensors & bioelectronics
information resource reference: Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus. Biosens Bioelectron. 2016 Jun 15; 80:230-236.
journal title abbreviation: Biosens Bioelectron
publication date: 2016-01-26T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 3314
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Once-daily dosing of aminoglycoside antibiotics.

Authorship 873858
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.

Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.
PubMed Identifier: 24518064
author list: Beauchemin C, Moerke NJ, Faloon P, Kaye KM
published in: Journal of biomolecular screening
information resource reference: Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes. J Biomol Screen. 2014 Jul; 19(6):947-58.
journal title abbreviation: J Biomol Screen
publication date: 2014-02-11T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 905758
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation.

Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation.
PubMed Identifier: 27307564
author list: Cerqueira SA, Tan M, Li S, Juillard F, McVey CE, Kaye KM, Simas JP
published in: Journal of virology
information resource reference: Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation. J Virol. 2016 09 01; 90(17):7667-83.
journal title abbreviation: J Virol
publication date: 2016-08-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Goudsmit, Jaap
eCommons Login: JG286
first name: Jaap
last name: Goudsmit
full name: Jaap Goudsmit, M.D., Ph.D.
has faculty rank: Full Professor
Person ID: 152618
person in primary position: Adjunct Professor of Epidemiology and Infectious Diseases
type: Agent
type: Person
preferred title: Adjunct Professor of Epidemiology and Infectious Diseases

Authorship 909801
type: Authorship
author rank in publication: 4
linked author: Kaye, Kenneth
linked information resource: Kaposi's Sarcoma Herpesvirus Genome Persistence.

Kaposi's Sarcoma Herpesvirus Genome Persistence.
PubMed Identifier: 27570517
author list: Juillard F, Tan M, Li S, Kaye KM
published in: Frontiers in microbiology
information resource reference: Kaposi's Sarcoma Herpesvirus Genome Persistence. Front Microbiol. 2016; 7:1149.
journal title abbreviation: Front Microbiol
publication date: 2016-08-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Platform technology for detection of cancer-associated viruses in HIV patients
end date: 2021-06-30
principal investigator name: DEMIRCI, UTKAN
start date: 2015-09-03
type: Grant
sponsor award id: R01DE024971

MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
end date: 2012-08-09
principal investigator name: COSTELLO, CATHERINE E.
start date: 1996-07-01
type: Grant
sponsor award id: P41RR010888

Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
end date: 2010-08-31
principal investigator name: KAYE, KENNETH M
start date: 2007-09-30
type: Grant
sponsor award id: R21NS061738

ORAL PATHOGENESIS OF GAMMAHERPESVIRUS INFECTIONS
end date: 2007-08-31
principal investigator name: WANG, FREDERICK C.
start date: 2001-09-15
type: Grant
sponsor award id: P01DE014388

EBV MUTANTS WITH ALTERED LMPI (TRANSFORMING) GENES
end date: 1997-08-31
principal investigator name: KAYE, KENNETH M
start date: 1992-09-01
type: Grant
sponsor award id: K11CA001568

GENETIC AND BIOCHEMICAL STUDIES OF THE EBV LMP1 ONCOGENE
end date: 2000-04-30
principal investigator name: KAYE, KENNETH M
start date: 1995-07-01
type: Grant
sponsor award id: R01CA067380

Genetic and Biochemical Studies of KSHV LANA
end date: 2020-03-31
principal investigator name: KAYE, KENNETH M
start date: 1999-07-01
type: Grant
sponsor award id: R01CA082036

KSHV latent infection replication
end date: 2026-03-31
principal investigator name: KAYE, KENNETH M
start date: 2015-04-01
type: Grant
sponsor award id: R01DE025208

Inhibitors of Kaposi???s Sarcoma Herpesvirus
end date: 2012-08-31
principal investigator name: KAYE, KENNETH M
start date: 2010-09-27
type: Grant
sponsor award id: R21NS067638

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: KSHV latent infection replication

Co-Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: Platform technology for detection of cancer-associated viruses in HIV patients

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: GENETIC AND BIOCHEMICAL STUDIES OF THE EBV LMP1 ONCOGENE

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: EBV MUTANTS WITH ALTERED LMPI (TRANSFORMING) GENES

Co-Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: Genetic and Biochemical Studies of KSHV LANA

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection

Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: Inhibitors of Kaposi???s Sarcoma Herpesvirus

Co-Principal Investigator
type: Researcher Role
researcher role of: Kaye, Kenneth
contributes to: ORAL PATHOGENESIS OF GAMMAHERPESVIRUS INFECTIONS

Authorship 931518
type: Authorship
author rank in publication: 6
linked author: Kaye, Kenneth
linked information resource: Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation.

Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation.
PubMed Identifier: 27864512
author list: Liang J, Zhou H, Gerdt C, Tan M, Colson T, Kaye KM, Kieff E, Zhao B
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14121-14126.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2016-11-18T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 942365
type: Authorship
author rank in publication: 12
linked author: Kaye, Kenneth
linked information resource: 3-D Microwell Array System for Culturing Virus Infected Tumor Cells.

3-D Microwell Array System for Culturing Virus Infected Tumor Cells.
PubMed Identifier: 28004818
author list: El Assal R, Gurkan UA, Chen P, Juillard F, Tocchio A, Chinnasamy T, Beauchemin C, Unluisler S, Canikyan S, Holman A, Srivatsa S, Kaye KM, Demirci U
published in: Scientific reports
information resource reference: 3-D Microwell Array System for Culturing Virus Infected Tumor Cells. Sci Rep. 2016 12 22; 6:39144.
journal title abbreviation: Sci Rep
publication date: 2016-12-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 448683
type: Authorship
author rank in publication: 2
linked author: Kaye, Kenneth
linked information resource: Beta-lactam antibiotics: newer formulations and newer agents.

Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.
PubMed Identifier: 8855313
author list: Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11085-90.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-10-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.
PubMed Identifier: 8943365
author list: Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G
published in: Molecular and cellular biology
information resource reference: Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol Cell Biol. 1996 Dec; 16(12):7098-108.
journal title abbreviation: Mol Cell Biol
publication date: 1996-12-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence.
PubMed Identifier: 14980483
author list: Komatsu T, Ballestas ME, Barbera AJ, Kelley-Clarke B, Kaye KM
published in: Virology
information resource reference: KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology. 2004 Feb 20; 319(2):225-36.
journal title abbreviation: Virology
publication date: 2004-02-20T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors.
PubMed Identifier: 9205097
author list: Eliopoulos AG, Stack M, Dawson CW, Kaye KM, Hodgkin L, Sihota S, Rowe M, Young LS
published in: Oncogene
information resource reference: Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors. Oncogene. 1997 Jun 19; 14(24):2899-916.
journal title abbreviation: Oncogene
publication date: 1997-06-19T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.
PubMed Identifier: 11238851
author list: Ballestas ME, Kaye KM
published in: Journal of virology
information resource reference: Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. J Virol. 2001 Apr; 75(7):3250-8.
journal title abbreviation: J Virol
publication date: 2001-04-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.
PubMed Identifier: 19909894
author list: Bazan JA, Martin SI, Kaye KM
published in: Infectious disease clinics of North America
information resource reference: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Infect Dis Clin North Am. 2009 Dec; 23(4):983-96, ix.
journal title abbreviation: Infect Dis Clin North Am
publication date: 2009-12-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes.
PubMed Identifier: 16979209
author list: Kelley-Clarke B, Ballestas ME, Komatsu T, Kaye KM
published in: Virology
information resource reference: Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes. Virology. 2007 Jan 20; 357(2):149-57.
journal title abbreviation: Virology
publication date: 2006-09-18T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.
PubMed Identifier: 8943059
author list: Ansieau S, Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss HJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14053-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-11-26T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.
PubMed Identifier: 10213686
author list: Ballestas ME, Chatis PA, Kaye KM
published in: Science (New York, N.Y.)
information resource reference: Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999 Apr 23; 284(5414):641-4.
journal title abbreviation: Science
publication date: 1999-04-23T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.
PubMed Identifier: 16469929
author list: Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM
published in: Science (New York, N.Y.)
information resource reference: The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science. 2006 Feb 10; 311(5762):856-61.
journal title abbreviation: Science
publication date: 2006-02-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.
PubMed Identifier: 10196286
author list: Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU
published in: Journal of virology
information resource reference: Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999 May; 73(5):3913-9.
journal title abbreviation: J Virol
publication date: 1999-05-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 981716
type: Authorship
author rank in publication: 19
linked author: Kaye, Kenneth
linked information resource: Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.

Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
PubMed Identifier: 28504647
author list: Nayar U, Sadek J, Reichel J, Hernandez-Hopkins D, Akar G, Barelli PJ, Sahai MA, Zhou H, Totonchy J, Jayabalan D, Niesvizky R, Guasparri I, Hassane D, Liu Y, Sei S, Shoemaker RH, Warren JD, Elemento O, Kaye KM, Cesarman E
published in: The Journal of clinical investigation
information resource reference: Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. J Clin Invest. 2017 Jun 01; 127(6):2066-2080.
journal title abbreviation: J Clin Invest
publication date: 2017-05-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation.
PubMed Identifier: 10559372
author list: Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E
published in: Journal of virology
information resource reference: An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):10525-30.
journal title abbreviation: J Virol
publication date: 1999-12-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

181 Longwood Ave
type: Address
address line 1: Brigham & Women's Hospital
address line 2: Infectious Disease
address line 3: 181 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence.
PubMed Identifier: 14671111
author list: Barbera AJ, Ballestas ME, Kaye KM
published in: Journal of virology
information resource reference: The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol. 2004 Jan; 78(1):294-301.
journal title abbreviation: J Virol
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient.
PubMed Identifier: 9700178
author list: Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC
published in: The New England journal of medicine
information resource reference: Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998 Aug 13; 339(7):444-9.
journal title abbreviation: N Engl J Med
publication date: 1998-08-13T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Beta-lactam antibiotics: newer formulations and newer agents.
PubMed Identifier: 15308278
author list: Martin SI, Kaye KM
published in: Infectious disease clinics of North America
information resource reference: Beta-lactam antibiotics: newer formulations and newer agents. Infect Dis Clin North Am. 2004 Sep; 18(3):603-19, ix.
journal title abbreviation: Infect Dis Clin North Am
publication date: 2004-09-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Once-daily dosing of aminoglycoside antibiotics.
PubMed Identifier: 10829267
author list: Fisman DN, Kaye KM
published in: Infectious disease clinics of North America
information resource reference: Once-daily dosing of aminoglycoside antibiotics. Infect Dis Clin North Am. 2000 Jun; 14(2):475-87.
journal title abbreviation: Infect Dis Clin North Am
publication date: 2000-06-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1010211
type: Authorship
author rank in publication: 11
linked author: Kaye, Kenneth
linked information resource: Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.
PubMed Identifier: 28910389
author list: Habison AC, de Miranda MP, Beauchemin C, Tan M, Cerqueira SA, Correia B, Ponnusamy R, Usherwood EJ, McVey CE, Simas JP, Kaye KM
published in: PLoS pathogens
information resource reference: Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA. PLoS Pathog. 2017 Sep; 13(9):e1006555.
journal title abbreviation: PLoS Pathog
publication date: 2017-09-14T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA.
PubMed Identifier: 15564510
author list: Srinivasan V, Komatsu T, Ballestas ME, Kaye KM
published in: Journal of virology
information resource reference: Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA. J Virol. 2004 Dec; 78(24):14033-8.
journal title abbreviation: J Virol
publication date: 2004-12-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen.
PubMed Identifier: 11792061
author list: Komatsu T, Barbera AJ, Ballestas ME, Kaye KM
published in: Viral immunology
information resource reference: The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen. Viral Immunol. 2001; 14(4):311-7.
journal title abbreviation: Viral Immunol
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding.
PubMed Identifier: 17287261
author list: Kelley-Clarke B, Ballestas ME, Srinivasan V, Barbera AJ, Komatsu T, Harris TA, Kazanjian M, Kaye KM
published in: Journal of virology
information resource reference: Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding. J Virol. 2007 Apr; 81(8):4348-56.
journal title abbreviation: J Virol
publication date: 2007-02-07T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability.
PubMed Identifier: 23325691
author list: Dheekollu J, Chen HS, Kaye KM, Lieberman PM
published in: Journal of virology
information resource reference: Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J Virol. 2013 Apr; 87(7):3699-709.
journal title abbreviation: J Virol
publication date: 2013-01-16T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A charged and contoured surface on the nucleosome regulates chromatin compaction.
PubMed Identifier: 17965723
author list: Chodaparambil JV, Barbera AJ, Lu X, Kaye KM, Hansen JC, Luger K
published in: Nature structural & molecular biology
information resource reference: A charged and contoured surface on the nucleosome regulates chromatin compaction. Nat Struct Mol Biol. 2007 Nov; 14(11):1105-7.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2007-10-28T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.
PubMed Identifier: 19225000
author list: Kelley-Clarke B, De Leon-Vazquez E, Slain K, Barbera AJ, Kaye KM
published in: Journal of virology
information resource reference: Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence. J Virol. 2009 May; 83(9):4326-37.
journal title abbreviation: J Virol
publication date: 2009-02-18T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.
PubMed Identifier: 9037073
author list: Izumi KM, Kaye KM, Kieff ED
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1447-52.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-02-18T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

The KSHV latency-associated nuclear antigen: a multifunctional protein.
PubMed Identifier: 11861213
author list: Komatsu T, Ballestas ME, Barbera AJ, Kaye KM
published in: Frontiers in bioscience : a journal and virtual library
information resource reference: The KSHV latency-associated nuclear antigen: a multifunctional protein. Front Biosci. 2002 Mar 01; 7:d726-30.
journal title abbreviation: Front Biosci
publication date: 2002-03-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter.
PubMed Identifier: 12414930
author list: Li H, Komatsu T, Dezube BJ, Kaye KM
published in: Journal of virology
information resource reference: The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter. J Virol. 2002 Dec; 76(23):11880-8.
journal title abbreviation: J Virol
publication date: 2002-12-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource