Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature. Clin Infect Dis. 1992 May; 14(5):1010-4.
Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature.
Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Luger K, Kaye KM
Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome. Cell Cycle. 2006 May; 5(10):1048-52.
Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.
Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May; 81(9):4904-8.
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation. J Virol. 1994 Jul; 68(7):4369-76.
Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation.
Proceedings of the National Academy of Sciences of the United States of America
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9150-4.
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.
Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test. Am Heart J. 1989 May; 117(5):1169-71.
Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test.
Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL
Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol. 1986 Jul; 59(1):90-7.
Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).
The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiol. 2011 Dec; 6(12):1399-413.
The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.
Infectious disease clinics of North America
Topical antibacterial agents. Infect Dis Clin North Am. 1995 Sep; 9(3):547-59.
KSHV LANA's expanding bag of tricks. Blood. 2008 May 01; 111(9):4425-6.
Pires de Miranda M, Quendera AP, McVey CE, Kaye KM, Simas JP
In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4. J Virol. 2018 11 01; 92(21).
In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4.
The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence. J Virol. 2011 Aug; 85(15):7622-33.
The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence.
Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Med Clin North Am. 2011 Jul; 95(4):743-60, viii.
Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.
Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM
Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence. J Virol. 2012 Nov; 86(21):11863-76.
Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence.
You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19.
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes.
Rapid and quantitative assessment of KSHV LANA-mediated DNA replication. Arch Virol. 2011 Aug; 156(8):1323-33.
Rapid and quantitative assessment of KSHV LANA-mediated DNA replication.
The newer macrolides. Azithromycin and clarithromycin. Infect Dis Clin North Am. 1995 Sep; 9(3):731-45.
The newer macrolides. Azithromycin and clarithromycin.
Juillard F, De León Vázquez E, Tan M, Li S, Kaye KM
Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance. J Virol. 2019 03 15; 93(6).
Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance.
The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J Virol. 1995 Feb; 69(2):675-83.
The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.
Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K
NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 02; 15(2):e1007628.
NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
Harvard T.H. Chan School of Public Health
Elkan Blout Professor of Environmental Genetics
Higgins Professor of Microbiology and Molecular Genetics
Professor of Biological Chemistry and Molecular Pharmacology
George and Sandra K. Schussel Associate Professor of Medicine in the Field of Infectious Diseases
William Ellery Channing Professor of Medicine
Gong J, Meyerowitz EA, Isidro RA, Kaye KM
Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease. BMJ Case Rep. 2019 Sep 30; 12(9).
Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease.
Slevin MK, Wollison BM, Powers W, Burns RT, Patel N, Ducar MD, Starrett GJ, Garcia EP, Manning DK, Cheng J, Hanna GJ, Kaye KM, Van Hummelen P, Nag A, Thorner AR, DeCaprio JA, MacConaill LE
The Journal of molecular diagnostics : JMD
ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487.
ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome.
Genetic and Biochemical Studies of KSHV LANA
Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, Liu B, Álvarez ÁL, Tan M, Szymula A, Kaye KM, Simas JP
KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22443-22451.
KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence.
Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, Narita Y, Hou I, Liang J, Li S, Xiao H, Gottwein E, Kaye KM, Teng M, Zhao B
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors. Nat Commun. 2020 12 09; 11(1):6318.
Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors.
Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2. Proc Natl Acad Sci U S A. 2021 11 09; 118(45).
Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2.
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM
MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 2021 12 16; 49(22):12895-12911.
MLL1 is regulated by KSHV LANA and is important for virus latency.
Wada N, Li Y, Hino T, Gagne S, Valtchinov VI, Gay E, Nishino M, Madore B, Guttmann CRG, Bond S, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
COVID-19 Vaccination reduced pneumonia severity. Eur J Radiol Open. 2022; 9:100456.
COVID-19 Vaccination reduced pneumonia severity.
American journal of respiratory and critical care medicine
Viral Infection, Pulmonary Fibrosis, and Long COVID. Am J Respir Crit Care Med. 2023 03 15; 207(6):647-649.
Viral Infection, Pulmonary Fibrosis, and Long COVID.
Reply to Kamp et al.: Novel Insight into Pulmonary Fibrosis and Long Covid. Am J Respir Crit Care Med. 2023 04 15; 207(8):1108.
Reply to Kamp et al.: Novel Insight into Pulmonary Fibrosis and Long Covid.
Research Fellow in Biological Chemistry and Molecular Pharmacology
Hino T, Nishino M, Valtchinov VI, Gagne S, Gay E, Wada N, Tseng SC, Madore B, Guttmann CRG, Ishigami K, Li Y, Christiani DC, Hunninghake GM, Levy BD, Kaye KM, Hatabu H
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans. Eur J Radiol Open. 2023; 10:100483.
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans.
Szymula A, Samayoa-Reyes G, Ogolla S, Liu B, Li S, George A, Van Sciver N, Rochford R, Simas JP, Kaye KM
Macrophages drive KSHV B cell latency. Cell Rep. 2023 07 25; 42(7):112767.
Wada N, Li Y, Gagne S, Hino T, Valtchinov VI, Gay E, Nishino M, Hammer MM, Madore B, Guttmann CRG, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants. Medicine (Baltimore). 2023 Dec 01; 102(48):e36417.
Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants.
Li S, Liu B, Tan M, Juillard F, Szymula A, Álvarez ÁL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM
Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Nucleic Acids Res. 2024 Feb 28; 52(4):1814-1829.
Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome.
Li S, Wang M, Van Sciver N, Szymula A, Tumuluri VS, George A, Ramachandran A, Raina K, Costa CN, Zhao B, Kazemian M, Simas JP, Kaye KM
Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection. PLoS Pathog. 2024 Jan; 20(1):e1011907.
Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.
Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation. PLoS Pathog. 2013; 9(8):e1003554.
Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation.
Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence. J Virol. 2013 Nov; 87(22):12270-83.
Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence.
Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. PLoS Pathog. 2013; 9(10):e1003673.
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency.
Lee SM, Avalos CL, Miliotis C, Doh HM, Chan E, Kaye KM, Slack FJ
bioRxiv : the preprint server for biology
Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression. bioRxiv. 2025 Jan 24.
Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.
De León Vázquez E, Juillard F, Rosner B, Kaye KM
A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence. Virology. 2014 Jan 05; 448:344-55.
A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence.
Adjunct Professor of Epidemiology and Infectious Diseases
Sun Q, Tsurimoto T, Juillard F, Li L, Li S, De León Vázquez E, Chen S, Kaye K
Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):11816-21.
Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence.
Shafiee H, Kanakasabapathy MK, Juillard F, Keser M, Sadasivam M, Yuksekkaya M, Hanhauser E, Henrich TJ, Kuritzkes DR, Kaye KM, Demirci U
Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva. Sci Rep. 2015 Jun 05; 5:9919.
Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva.
Hu Z, Blackman MA, Kaye KM, Usherwood EJ
Journal of immunology (Baltimore, Md. : 1950)
Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68. J Immunol. 2015 Mar 15; 194(6):2746-56.
Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68.
Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U
Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63.
Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics.
Li S, Tan M, Juillard F, Ponnusamy R, Correia B, Simas JP, Carrondo MA, McVey CE, Kaye KM
The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence. J Biol Chem. 2015 Nov 20; 290(47):28084-28096.
The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. Nucleic Acids Res. 2015 Nov 16; 43(20):10039-54.
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Safavieh M, Khetani S, Juillard F, Kaul V, Kanakasabapathy MK, Kaye KM, Shafiee H
Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus. Biosens Bioelectron. 2016 Jun 15; 80:230-236.
Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus.
Beauchemin C, Moerke NJ, Faloon P, Kaye KM
Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes. J Biomol Screen. 2014 Jul; 19(6):947-58.
Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes.
Cerqueira SA, Tan M, Li S, Juillard F, McVey CE, Kaye KM, Simas JP
Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation. J Virol. 2016 09 01; 90(17):7667-83.
Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation.
Kaposi's Sarcoma Herpesvirus Genome Persistence. Front Microbiol. 2016; 7:1149.
Kaposi's Sarcoma Herpesvirus Genome Persistence.
Platform technology for detection of cancer-associated viruses in HIV patients
MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
ORAL PATHOGENESIS OF GAMMAHERPESVIRUS INFECTIONS
EBV MUTANTS WITH ALTERED LMPI (TRANSFORMING) GENES
GENETIC AND BIOCHEMICAL STUDIES OF THE EBV LMP1 ONCOGENE
Inhibitors of Kaposi???s Sarcoma Herpesvirus
Liang J, Zhou H, Gerdt C, Tan M, Colson T, Kaye KM, Kieff E, Zhao B
Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14121-14126.
Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation.
El Assal R, Gurkan UA, Chen P, Juillard F, Tocchio A, Chinnasamy T, Beauchemin C, Unluisler S, Canikyan S, Holman A, Srivatsa S, Kaye KM, Demirci U
3-D Microwell Array System for Culturing Virus Infected Tumor Cells. Sci Rep. 2016 12 22; 6:39144.
3-D Microwell Array System for Culturing Virus Infected Tumor Cells.
Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11085-90.
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.
Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol Cell Biol. 1996 Dec; 16(12):7098-108.
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.
Komatsu T, Ballestas ME, Barbera AJ, Kelley-Clarke B, Kaye KM
KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology. 2004 Feb 20; 319(2):225-36.
KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence.
Eliopoulos AG, Stack M, Dawson CW, Kaye KM, Hodgkin L, Sihota S, Rowe M, Young LS
Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors. Oncogene. 1997 Jun 19; 14(24):2899-916.
Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors.
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. J Virol. 2001 Apr; 75(7):3250-8.
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.
Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Infect Dis Clin North Am. 2009 Dec; 23(4):983-96, ix.
Kelley-Clarke B, Ballestas ME, Komatsu T, Kaye KM
Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes. Virology. 2007 Jan 20; 357(2):149-57.
Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes.
Ansieau S, Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss HJ
Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14053-8.
Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999 Apr 23; 284(5414):641-4.
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.
Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science. 2006 Feb 10; 311(5762):856-61.
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.
Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU
Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999 May; 73(5):3913-9.
Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.
Nayar U, Sadek J, Reichel J, Hernandez-Hopkins D, Akar G, Barelli PJ, Sahai MA, Zhou H, Totonchy J, Jayabalan D, Niesvizky R, Guasparri I, Hassane D, Liu Y, Sei S, Shoemaker RH, Warren JD, Elemento O, Kaye KM, Cesarman E
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. J Clin Invest. 2017 Jun 01; 127(6):2066-2080.
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E
An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):10525-30.
An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation.
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol. 2004 Jan; 78(1):294-301.
The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence.
Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC
Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998 Aug 13; 339(7):444-9.
Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient.
Beta-lactam antibiotics: newer formulations and newer agents. Infect Dis Clin North Am. 2004 Sep; 18(3):603-19, ix.
Beta-lactam antibiotics: newer formulations and newer agents.
Once-daily dosing of aminoglycoside antibiotics. Infect Dis Clin North Am. 2000 Jun; 14(2):475-87.
Once-daily dosing of aminoglycoside antibiotics.
Habison AC, de Miranda MP, Beauchemin C, Tan M, Cerqueira SA, Correia B, Ponnusamy R, Usherwood EJ, McVey CE, Simas JP, Kaye KM
Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA. PLoS Pathog. 2017 Sep; 13(9):e1006555.
Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.
Srinivasan V, Komatsu T, Ballestas ME, Kaye KM
Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA. J Virol. 2004 Dec; 78(24):14033-8.
Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA.
Komatsu T, Barbera AJ, Ballestas ME, Kaye KM
The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen. Viral Immunol. 2001; 14(4):311-7.
The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen.
Kelley-Clarke B, Ballestas ME, Srinivasan V, Barbera AJ, Komatsu T, Harris TA, Kazanjian M, Kaye KM
Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding. J Virol. 2007 Apr; 81(8):4348-56.
Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding.
Dheekollu J, Chen HS, Kaye KM, Lieberman PM
Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J Virol. 2013 Apr; 87(7):3699-709.
Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability.
Chodaparambil JV, Barbera AJ, Lu X, Kaye KM, Hansen JC, Luger K
A charged and contoured surface on the nucleosome regulates chromatin compaction. Nat Struct Mol Biol. 2007 Nov; 14(11):1105-7.
A charged and contoured surface on the nucleosome regulates chromatin compaction.
Kelley-Clarke B, De Leon-Vazquez E, Slain K, Barbera AJ, Kaye KM
Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence. J Virol. 2009 May; 83(9):4326-37.
Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.
The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1447-52.
The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.
Komatsu T, Ballestas ME, Barbera AJ, Kaye KM
Frontiers in bioscience : a journal and virtual library
The KSHV latency-associated nuclear antigen: a multifunctional protein. Front Biosci. 2002 Mar 01; 7:d726-30.
The KSHV latency-associated nuclear antigen: a multifunctional protein.
The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter. J Virol. 2002 Dec; 76(23):11880-8.
The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter.