Oser, Matthew
eCommons Login: MGO5
first name: Matthew
last name: Oser
coauthor of: Kaelin, William
coauthor of: Signoretti, Sabina
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coauthor of: Qiu, Xintao
full name: Matthew Gilbert Oser, M.D.,Ph.D.
has faculty rank: Associate Professor
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type: Agent
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selected publications: Authorship 1812137
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selected publications: Authorship 150366
selected publications: Authorship 436567
selected publications: Authorship 304584
selected publications: Authorship 86672
selected publications: Authorship 254272
selected publications: Authorship 9150
research areas: Small Cell Lung Carcinoma
research areas: Lung Neoplasms
research areas: Receptor, Notch2
research areas: Cyclin A
research areas: Cortactin
research activities: Principal Investigator
mailing address: 450 Brookline Ave
middle name or initial: Gilbert
positions: Associate Professor of Medicine
phone: 617/732-5845
preferred title: Associate Professor of Medicine

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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.
PubMed Identifier: 19373774
author list: Desmarais V, Yamaguchi H, Oser M, Soon L, Mouneimne G, Sarmiento C, Eddy R, Condeelis J
published in: Cell motility and the cytoskeleton
information resource reference: N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton. 2009 Jun; 66(6):303-16.
journal title abbreviation: Cell Motil Cytoskeleton
publication date: 2009-06-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
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Authorship 1055521
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver.

Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver.
PubMed Identifier: 29374051
author list: Oser MG, Jänne PA
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Small-Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver. Clin Cancer Res. 2018 04 15; 24(8):1775-1776.
journal title abbreviation: Clin Cancer Res
publication date: 2018-01-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1056141
type: Authorship
author rank in publication: 8
linked author: Oser, Matthew
linked information resource: Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.
PubMed Identifier: 29610306
author list: McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3741-E3748.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2018-04-02T00:00:00
year: 2018
type: Academic Article
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Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.
PubMed Identifier: 20971703
author list: Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J
published in: Journal of cell science
information resource reference: Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia. J Cell Sci. 2010 Nov 01; 123(Pt 21):3662-73.
journal title abbreviation: J Cell Sci
publication date: 2010-11-01T00:00:00
year: 2010
type: Academic Article
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An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.
PubMed Identifier: 21257711
author list: Mader CC, Oser M, Magalhaes MA, Bravo-Cordero JJ, Condeelis J, Koleske AJ, Gil-Henn H
published in: Cancer research
information resource reference: An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011 Mar 01; 71(5):1730-41.
journal title abbreviation: Cancer Res
publication date: 2011-01-21T00:00:00
year: 2011
type: Academic Article
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Authorship 1109387
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linked information resource: Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.

Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
PubMed Identifier: 30373918
author list: Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG
published in: Cancer discovery
information resource reference: Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019 02; 9(2):230-247.
journal title abbreviation: Cancer Discov
publication date: 2018-10-29T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.
PubMed Identifier: 19704022
author list: Oser M, Yamaguchi H, Mader CC, Bravo-Cordero JJ, Arias M, Chen X, Desmarais V, van Rheenen J, Koleske AJ, Condeelis J
published in: The Journal of cell biology
information resource reference: Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol. 2009 Aug 24; 186(4):571-87.
journal title abbreviation: J Cell Biol
publication date: 2009-08-24T00:00:00
year: 2009
type: Academic Article
type: Article
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Authorship 1134574
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linked information resource: Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.

Authorship 1139399
type: Authorship
author rank in publication: 10
linked author: Oser, Matthew
linked information resource: Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
PubMed Identifier: 30799286
author list: Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS
published in: Cell metabolism
information resource reference: Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 05 07; 29(5):1166-1181.e6.
journal title abbreviation: Cell Metab
publication date: 2019-02-21T00:00:00
year: 2019
type: Academic Article
type: Article
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type: Information Resource

Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB.
PubMed Identifier: 30833638
author list: Schade AE, Oser MG, Nicholson HE, DeCaprio JA
published in: Oncogene
information resource reference: Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Oncogene. 2019 06; 38(25):4962-4976.
journal title abbreviation: Oncogene
publication date: 2019-03-04T00:00:00
year: 2019
type: Academic Article
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Cortactin
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number of authors: 19
number of publications: 26
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Lung Neoplasms
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Cyclin A
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Small Cell Lung Carcinoma
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Receptor, Notch2
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number of publications: 94
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Harvard T.H. Chan School of Public Health
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Christiani, David
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Signoretti, Sabina
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Barbie, David
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Sholl, Lynette
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Sequist, Lecia
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Spektor, Alexander
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Kaelin, William
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Shaw, Alice
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linked information resource: Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.

Authorship 1204555
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linked author: Oser, Matthew
linked information resource: The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.
PubMed Identifier: 31727771
author list: Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG
published in: Genes & development
information resource reference: The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes Dev. 2019 12 01; 33(23-24):1718-1738.
journal title abbreviation: Genes Dev
publication date: 2019-11-14T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Landry Family Professor of Medicine in the Field of Medical Oncology
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
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position in organization: Massachusetts General Hospital

Sidney Farber Professor of Medicine
is primary position: true
position in department: Medicine
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sort order: 1
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HR job title: Sidney Farber Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 1215580
type: Authorship
author rank in publication: 4
linked author: Oser, Matthew
linked information resource: CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.
PubMed Identifier: 31883968
author list: Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK
published in: Cancer cell
information resource reference: CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 01 13; 37(1):37-54.e9.
journal title abbreviation: Cancer Cell
publication date: 2019-12-26T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1223395
type: Authorship
author rank in publication: 28
linked author: Oser, Matthew
linked information resource: New Approaches to SCLC Therapy: From the Laboratory to the Clinic.

New Approaches to SCLC Therapy: From the Laboratory to the Clinic.
PubMed Identifier: 32018053
author list: Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG
published in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
information resource reference: New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol. 2020 04; 15(4):520-540.
journal title abbreviation: J Thorac Oncol
publication date: 2020-02-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Yang, Chi-Fu
eCommons Login: CJY3
first name: Chi-Fu
last name: Yang
full name: Chi-Fu Jeffrey Yang, M.D.
has faculty rank: Associate Professor
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 58795
person in primary position: Associate Professor of Surgery
type: Agent
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preferred title: Associate Professor of Surgery

Authorship 1326065
type: Authorship
author rank in publication: 25
linked author: Oser, Matthew
linked information resource: Targeting oncoproteins with a positive selection assay for protein degraders.

Targeting oncoproteins with a positive selection assay for protein degraders.
PubMed Identifier: 33547076
author list: Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG
published in: Science advances
information resource reference: Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv. 2021 02; 7(6).
journal title abbreviation: Sci Adv
publication date: 2021-02-05T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1337518
type: Authorship
author rank in publication: 42
linked author: Oser, Matthew
linked information resource: Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
PubMed Identifier: 33707236
author list: Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigí M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Cañadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Jänne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA
published in: Cancer discovery
information resource reference: Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Cancer Discov. 2021 08; 11(8):1952-1969.
journal title abbreviation: Cancer Discov
publication date: 2021-03-11T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1414810
type: Authorship
author rank in publication: 19
linked author: Oser, Matthew
linked information resource: Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer.

Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer.
PubMed Identifier: 34810201
author list: Hong D, Knelson EH, Li Y, Durmaz YT, Gao W, Walton E, Vajdi A, Thai T, Sticco-Ivins M, Sabet AH, Jones KL, Schinzel AC, Bronson RT, Nguyen QD, Tolstorukov MY, Vivero M, Signoretti S, Barbie DA, Oser MG
published in: Cancer research
information resource reference: Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer. Cancer Res. 2022 01 15; 82(2):248-263.
journal title abbreviation: Cancer Res
publication date: 2021-11-22T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1483760
type: Authorship
author rank in publication: 17
linked author: Oser, Matthew
linked information resource: Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.

Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
PubMed Identifier: 36008402
author list: Chen HY, Durmaz YT, Li Y, Sabet AH, Vajdi A, Denize T, Walton E, Laimon YN, Doench JG, Mahadevan NR, Losman JA, Barbie DA, Tolstorukov MY, Rudin CM, Sen T, Signoretti S, Oser MG
published in: Nature communications
information resource reference: Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1. Nat Commun. 2022 08 25; 13(1):4998.
journal title abbreviation: Nat Commun
publication date: 2022-08-25T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1581746
type: Authorship
author rank in publication: 24
linked author: Oser, Matthew
linked information resource: KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.

KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
PubMed Identifier: 37591951
author list: Duplaquet L, Li Y, Booker MA, Xie Y, Olsen SN, Patel RA, Hong D, Hatton C, Denize T, Walton E, Laimon YN, Li R, Jiang Y, Bronson RT, Southard J, Li S, Signoretti S, Qiu X, Cejas P, Armstrong SA, Long HW, Tolstorukov MY, Haffner MC, Oser MG
published in: Nature cell biology
information resource reference: KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. Nat Cell Biol. 2023 09; 25(9):1346-1358.
journal title abbreviation: Nat Cell Biol
publication date: 2023-08-17T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1602608
type: Authorship
author rank in publication: 30
linked author: Oser, Matthew
linked information resource: Liquid biopsy epigenomic profiling for cancer subtyping.

Liquid biopsy epigenomic profiling for cancer subtyping.
PubMed Identifier: 37865722
author list: Baca SC, Seo JH, Davidsohn MP, Fortunato B, Semaan K, Sotudian S, Lakshminarayanan G, Diossy M, Qiu X, El Zarif T, Savignano H, Canniff J, Madueke I, Saliby RM, Zhang Z, Li R, Jiang Y, Taing L, Awad M, Chau CH, DeCaprio JA, Figg WD, Greten TF, Hata AN, Hodi FS, Hughes ME, Ligon KL, Lin N, Ng K, Oser MG, Meador C, Parsons HA, Pomerantz MM, Rajan A, Ritz J, Thakuria M, Tolaney SM, Wen PY, Long H, Berchuck JE, Szallasi Z, Choueiri TK, Freedman ML
published in: Nature medicine
information resource reference: Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2023 11; 29(11):2737-2741.
journal title abbreviation: Nat Med
publication date: 2023-10-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1608312
type: Authorship
author rank in publication: 22
linked author: Oser, Matthew
linked information resource: Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.

Authorship 1609162
type: Authorship
author rank in publication: 30
linked author: Oser, Matthew
linked information resource: Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping.

Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping.
PubMed Identifier: 38049623
author list: Baca SC, Seo JH, Davidsohn MP, Fortunato B, Semaan K, Sotudian S, Lakshminarayanan G, Diossy M, Qiu X, El Zarif T, Savignano H, Canniff J, Madueke I, Saliby RM, Zhang Z, Li R, Jiang Y, Taing L, Awad M, Chau CH, DeCaprio JA, Figg WD, Greten TF, Hata AN, Hodi FS, Hughes ME, Ligon KL, Lin N, Ng K, Oser MG, Meador C, Parsons HA, Pomerantz MM, Rajan A, Ritz J, Thakuria M, Tolaney SM, Wen PY, Long H, Berchuck JE, Szallasi Z, Choueiri TK, Freedman ML
published in: Nature medicine
information resource reference: Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2024 Mar; 30(3):907.
journal title abbreviation: Nat Med
publication date: 2024-03-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.
PubMed Identifier: 37992688
author list: Li Y, Mahadevan NR, Duplaquet L, Hong D, Durmaz YT, Jones KL, Cho H, Morrow M, Protti A, Poitras MJ, Springer BF, Bronson RT, Gong X, Hui YH, Du J, Southard J, Thai T, Li S, Lizotte PH, Gokhale PC, Nguyen QD, Oser MG
published in: Cell reports. Medicine
information resource reference: Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1. Cell Rep Med. 2023 11 21; 4(11):101282.
journal title abbreviation: Cell Rep Med
publication date: 2023-11-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1619813
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: Genetically-engineered mouse models of small cell lung cancer: the next generation.

Genetically-engineered mouse models of small cell lung cancer: the next generation.
PubMed Identifier: 38191672
author list: Oser MG, MacPherson D, Oliver TG, Sage J, Park KS
published in: Oncogene
information resource reference: Genetically-engineered mouse models of small cell lung cancer: the next generation. Oncogene. 2024 02; 43(7):457-469.
journal title abbreviation: Oncogene
publication date: 2024-01-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1623156
type: Authorship
author rank in publication: 9
linked author: Oser, Matthew
linked information resource: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.

Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.
PubMed Identifier: 38260422
author list: Singh PNP, Gu W, Madha S, Lynch AW, Cejas P, He R, Bhattacharya S, Gomez MM, Oser MG, Brown M, Long HW, Meyer CA, Zhou Q, Shivdasani RA
published in: bioRxiv : the preprint server for biology
information resource reference: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. bioRxiv. 2024 Jan 09.
journal title abbreviation: bioRxiv
publication date: 2024-01-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1628014
type: Authorship
author rank in publication: 24
linked author: Oser, Matthew
linked information resource: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.
PubMed Identifier: 38328215
author list: Duplaquet L, So K, Ying AW, Li X, Li Y, Qiu X, Li R, Singh S, Wu XS, Liu Q, Qi J, Somerville TDD, Heiling H, Mazzola E, Lee Y, Zoller T, Vakoc CR, Doench JG, Forrester WC, Abrams T, Long HW, Niederst MJ, Kadoch C, Oser MG
published in: bioRxiv : the preprint server for biology
information resource reference: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. bioRxiv. 2024 Jan 24.
journal title abbreviation: bioRxiv
publication date: 2024-01-24T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Surgery
position in organization: Massachusetts General Hospital

Mechanisms by which LSD1 Promotes Neuroendocrine Differentiation and Small Cell Lung Cancer
end date: 2027-11-30
principal investigator name: OSER, MATTHEW GILBERT
start date: 2022-12-06
type: Grant
sponsor award id: R37CA269990

Principal Investigator
type: Researcher Role
researcher role of: Oser, Matthew
contributes to: Mechanisms by which LSD1 Promotes Neuroendocrine Differentiation and Small Cell Lung Cancer

Authorship 1651656
type: Authorship
author rank in publication: 9
linked author: Oser, Matthew
linked information resource: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.

Authorship 1646648
type: Authorship
author rank in publication: 26
linked author: Oser, Matthew
linked information resource: A Lung Cancer Mouse Model Database.

A Lung Cancer Mouse Model Database.
PubMed Identifier: 38464291
author list: Cai L, Gao Y, DeBerardinis RJ, Acquaah-Mensah G, Aidinis V, Beane JE, Biswal S, Chen T, Concepcion-Crisol CP, Grüner BM, Jia D, Jones R, Kurie JM, Lee MG, Lindahl P, Lissanu Y, Lorz Lopez MC, Martinelli R, Mazur PK, Mazzilli SA, Mii S, Moll H, Moorehead R, Morrisey EE, Ng SR, Oser MG, Pandiri AR, Powell CA, Ramadori G, Santos Lafuente M, Snyder E, Sotillo R, Su KY, Taki T, Taparra K, Xia Y, van Veen E, Winslow MM, Xiao G, Rudin CM, Oliver TG, Xie Y, Minna JD
published in: bioRxiv : the preprint server for biology
information resource reference: A Lung Cancer Mouse Model Database. bioRxiv. 2024 May 14.
journal title abbreviation: bioRxiv
publication date: 2024-05-14T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.
PubMed Identifier: 38733993
author list: Singh PNP, Gu W, Madha S, Lynch AW, Cejas P, He R, Bhattacharya S, Muñoz Gomez M, Oser MG, Brown M, Long HW, Meyer CA, Zhou Q, Shivdasani RA
published in: Cell stem cell
information resource reference: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. Cell Stem Cell. 2024 Jul 05; 31(7):1038-1057.e11.
journal title abbreviation: Cell Stem Cell
publication date: 2024-05-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1660661
type: Authorship
author rank in publication: 19
linked author: Oser, Matthew
linked information resource: Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.
PubMed Identifier: 38912901
author list: El Zarif T, Meador CB, Qiu X, Seo JH, Davidsohn MP, Savignano H, Lakshminarayanan G, McClure HM, Canniff J, Fortunato B, Li R, Banwait MK, Semaan K, Eid M, Long H, Hung YP, Mahadevan NR, Barbie DA, Oser MG, Piotrowska Z, Choueiri TK, Baca SC, Hata AN, Freedman ML, Berchuck JE
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling. Clin Cancer Res. 2024 Sep 03; 30(17):3798-3811.
journal title abbreviation: Clin Cancer Res
publication date: 2024-09-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1667201
type: Authorship
author rank in publication: 29
linked author: Oser, Matthew
linked information resource: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.
PubMed Identifier: 39029464
author list: Duplaquet L, So K, Ying AW, Pal Choudhuri S, Li X, Xu GD, Li Y, Qiu X, Li R, Singh S, Wu XS, Hamilton S, Chien VD, Liu Q, Qi J, Somerville TDD, Heiling HM, Mazzola E, Lee Y, Zoller T, Vakoc CR, Doench JG, Forrester WC, Abrams T, Long HW, Niederst MJ, Drapkin BJ, Kadoch C, Oser MG
published in: Cancer cell
information resource reference: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Cancer Cell. 2024 Aug 12; 42(8):1352-1369.e13.
journal title abbreviation: Cancer Cell
publication date: 2024-07-18T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology
position in organization: Brigham and Women's Hospital

Authorship 1685346
type: Authorship
author rank in publication: 54
linked author: Oser, Matthew
linked information resource: Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.

Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.
PubMed Identifier: 39211113
author list: Singh S, Gleason CE, Fang M, Laimon YN, Khivansara V, Xie S, Durmaz YT, Sarkar A, Ngo K, Savla V, Li Y, Abu-Remaileh M, Li X, Tuladhar B, Odeh R, Hamkins-Indik F, He D, Membreno MW, Nosrati M, Gushwa NN, Leung SSF, Fraga-Walton B, Hernandez L, Baldomero MP, Lent BM, Spellmeyer D, Luna JF, Hoang D, Gritsenko Y, Chand M, DeMart MK, Metobo S, Bhatt C, Shapiro JA, Yang K, Dupper NJ, Bockus AT, Doench JG, Aggen JB, Liu LF, Levin B, Wang EW, Vendrell I, Fischer R, Kessler B, Gokhale PC, Signoretti S, Spektor A, Kreatsoulas C, Singh R, Earp DJ, Garcia PD, Nijhawan D, Oser MG
published in: bioRxiv : the preprint server for biology
information resource reference: Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity. bioRxiv. 2024 Aug 01.
journal title abbreviation: bioRxiv
publication date: 2024-08-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 9150
type: Authorship
author rank in publication: 4
linked author: Oser, Matthew
linked information resource: Polycomb group protein ezh2 controls actin polymerization and cell signaling.

Authorship 1743577
type: Authorship
author rank in publication: 30
linked author: Oser, Matthew
linked information resource: The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models.

Authorship 1750629
type: Authorship
author rank in publication: 2
linked author: Oser, Matthew
linked information resource: A circular RNA in neuroendocrine carcinomas.

A circular RNA in neuroendocrine carcinomas.
PubMed Identifier: 40250442
author list: Li Y, Oser MG
published in: Cancer cell
information resource reference: A circular RNA in neuroendocrine carcinomas. Cancer Cell. 2025 May 12; 43(5):812-814.
journal title abbreviation: Cancer Cell
publication date: 2025-04-17T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models.
PubMed Identifier: 40298430
author list: Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis RJ, Acquaah-Mensah GK, Aidinis V, Beane JE, Biswal S, Chen T, Concepcion-Crisol CP, Grüner BM, Jia D, Jones RA, Kurie JM, Lee MG, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur PK, Mazzilli SA, Mii S, Moll HP, Moorehead RA, Morrisey EE, Ng SR, Oser MG, Pandiri AR, Powell CA, Ramadori G, Santos M, Snyder EL, Sotillo R, Su KY, Taki T, Taparra K, Tran PT, Xia Y, van Veen JE, Winslow MM, Xiao G, Rudin CM, Oliver TG, Xie Y, Minna JD
published in: Cancer research
information resource reference: The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer Res. 2025 May 15; 85(10):1769-1783.
journal title abbreviation: Cancer Res
publication date: 2025-05-15T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Research Associate in Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Research Associate in Medicine
position in organization: Dana-Farber Cancer Institute

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology
position in organization: Brigham and Women's Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

George P. Canellos, MD, and Jean S. Canellos Professor of Medicine Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: George P. Canellos, MD, and Jean S. Canellos Professor of Medicine Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Qiu, Xintao
eCommons Login: XQ12
first name: Xintao
last name: Qiu
full name: Xintao Qiu, Ph.D.
has faculty rank: Other Faculty
Person ID: 127298
person in primary position: Research Associate in Medicine
type: Agent
type: Person
preferred title: Research Associate in Medicine

Authorship 736311
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: A severe photosensitivity dermatitis caused by crizotinib.

A severe photosensitivity dermatitis caused by crizotinib.
PubMed Identifier: 24926554
author list: Oser MG, Jänne PA
published in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
information resource reference: A severe photosensitivity dermatitis caused by crizotinib. J Thorac Oncol. 2014 Jul; 9(7):e51-e53.
journal title abbreviation: J Thorac Oncol
publication date: 2014-07-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1812137
type: Authorship
author rank in publication: 25
linked author: Oser, Matthew
linked information resource: Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer.

Authorship 1844604
type: Authorship
author rank in publication: 10
linked author: Oser, Matthew
linked information resource: Efficacy and Safety of Tarlatamab in a Patient With Advanced Delta-Like Ligand 3-Positive Large Cell Neuroendocrine Lung Carcinoma and Untreated Brain Metastases: A Case Report.

Authorship 1847172
type: Authorship
author rank in publication: 59
linked author: Oser, Matthew
linked information resource: Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors.

Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer.
PubMed Identifier: 40865518
author list: Hong D, Lyu Y, Nayak R, Becker JS, Booker MA, Masuzawa K, Devos Z, Wang T, Saito S, Liu Q, Li Y, Li Z, Knelson EH, Thai T, Duplaquet L, Laimon YN, Roberti De Oliveira G, Signoretti S, Doench JG, Barbie DA, Tolystorukov MY, Qi J, Bernstein BE, Ge Y, Oser MG
published in: Developmental cell
information resource reference: Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer. Dev Cell. 2025 Dec 15; 60(24):3462-3479.e13.
journal title abbreviation: Dev Cell
publication date: 2025-08-26T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Efficacy and Safety of Tarlatamab in a Patient With Advanced Delta-Like Ligand 3-Positive Large Cell Neuroendocrine Lung Carcinoma and Untreated Brain Metastases: A Case Report.
PubMed Identifier: 40499092
author list: Gariazzo E, Laaksonen S, Canty S, De Almeida GR, Odintsov I, Santo V, Garbo E, Pecci F, Aldea M, Oser MG, Sholl L, Sands JM, Ricciuti B
published in: JCO precision oncology
information resource reference: Efficacy and Safety of Tarlatamab in a Patient With Advanced Delta-Like Ligand 3-Positive Large Cell Neuroendocrine Lung Carcinoma and Untreated Brain Metastases: A Case Report. JCO Precis Oncol. 2025 Jun; 9:e2500184.
journal title abbreviation: JCO Precis Oncol
publication date: 2025-06-11T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors.
PubMed Identifier: 40836083
author list: Singh S, Gleason CE, Fang M, Laimon YN, Khivansara V, Xie S, Durmaz YT, Sarkar A, Ngo K, Savla V, Li Y, Abu-Remaileh M, Li X, Locquet MA, Tuladhar B, Odeh R, Hamkins-Indik F, He D, Membreno MW, Nosrati M, Gushwa NN, Leung SSF, Fraga-Walton B, Hernandez L, Baldomero MP, Lent BM, Spellmeyer D, Luna JF, Hoang D, Gritsenko Y, Chand M, DeMart MK, Metobo S, Bhatt C, Shapiro JA, Yang K, Dupper NJ, Bockus AT, Fang J, Bambal R, Cremin P, Doench JG, Aggen JB, Liu LF, Levin B, Wang EW, Vendrell I, Fischer R, Kessler B, Gokhale PC, Signoretti S, Spektor A, Kreatsoulas C, Evangelista M, Singh R, Earp DJ, Nijhawan D, Garcia PD, Oser MG
published in: Nature
information resource reference: Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors. Nature. 2025 10; 646(8085):734-745.
journal title abbreviation: Nature
publication date: 2025-08-20T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor of Radiation Oncology
is primary position: true
position in department: Radiation Oncology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Radiation Oncology
position in organization: Dana-Farber Cancer Institute

Elkan Blout Professor of Environmental Genetics
is primary position: true
position in department: Environmental Health
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Elkan Blout Professor of Environmental Genetics
position in organization: Harvard T.H. Chan School of Public Health

Authorship 436567
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: The cofilin activity cycle in lamellipodia and invadopodia.

Authorship 803236
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.
PubMed Identifier: 25846096
author list: Oser MG, Niederst MJ, Sequist LV, Engelman JA
published in: The Lancet. Oncology
information resource reference: Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. Lancet Oncol. 2015 Apr; 16(4):e165-72.
journal title abbreviation: Lancet Oncol
publication date: 2015-04-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 254272
type: Authorship
author rank in publication: 3
linked author: Oser, Matthew
linked information resource: A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.

Authorship 479570
type: Authorship
author rank in publication: 6
linked author: Oser, Matthew
linked information resource: Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.

Authorship 814765
type: Authorship
author rank in publication: 2
linked author: Oser, Matthew
linked information resource: Transformation from NSCLC to SCLC: when did it happen? - Authors' reply.

Transformation from NSCLC to SCLC: when did it happen? - Authors' reply.
PubMed Identifier: 26149875
author list: Engelman JA, Oser MG, Niederst MJ, Sequist LV
published in: The Lancet. Oncology
information resource reference: Transformation from NSCLC to SCLC: when did it happen? - Authors' reply. Lancet Oncol. 2015 Jul; 16(7):e309-10.
journal title abbreviation: Lancet Oncol
publication date: 2015-07-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 304584
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation.

Authorship 853103
type: Authorship
author rank in publication: 6
linked author: Oser, Matthew
linked information resource: Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.
PubMed Identifier: 26631746
author list: Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15372-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-12-02T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 92367
type: Authorship
author rank in publication: 2
linked author: Oser, Matthew
linked information resource: A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

450 Brookline Ave
type: Address
address line 1: Dana-Farber Cancer Institute
address line 2: Lc-04117
address line 3: 450 Brookline Ave
city: Boston
postal code: 02215
state or province: MA

Authorship 492729
type: Authorship
author rank in publication: 2
linked author: Oser, Matthew
linked information resource: An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.

Authorship 86672
type: Authorship
author rank in publication: 3
linked author: Oser, Matthew
linked information resource: N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.

Authorship 443822
type: Authorship
author rank in publication: 1
linked author: Oser, Matthew
linked information resource: Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

Polycomb group protein ezh2 controls actin polymerization and cell signaling.
PubMed Identifier: 15882624
author list: Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R, Viale A, Reinberg D, Wülfing C, Tarakhovsky A
published in: Cell
information resource reference: Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell. 2005 May 06; 121(3):425-36.
journal title abbreviation: Cell
publication date: 2005-05-06T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis.
PubMed Identifier: 19081071
author list: Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB
published in: Developmental cell
information resource reference: A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell. 2008 Dec; 15(6):813-28.
journal title abbreviation: Dev Cell
publication date: 2008-12-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.
PubMed Identifier: 22105349
author list: Magalhaes MA, Larson DR, Mader CC, Bravo-Cordero JJ, Gil-Henn H, Oser M, Chen X, Koleske AJ, Condeelis J
published in: The Journal of cell biology
information resource reference: Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol. 2011 Nov 28; 195(5):903-20.
journal title abbreviation: J Cell Biol
publication date: 2011-11-21T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.
PubMed Identifier: 20850195
author list: Oser M, Dovas A, Cox D, Condeelis J
published in: European journal of cell biology
information resource reference: Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur J Cell Biol. 2011 Feb-Mar; 90(2-3):181-8.
journal title abbreviation: Eur J Cell Biol
publication date: 2010-09-17T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

New Therapeutic Targets in Small Cell Lung Cancer that are Epistatic or Synthetic Lethal with pRB Loss
end date: 2022-08-31
principal investigator name: OSER, MATTHEW GILBERT
start date: 2017-09-19
type: Grant
sponsor award id: K08CA222657

Principal Investigator
type: Researcher Role
researcher role of: Oser, Matthew
contributes to: New Therapeutic Targets in Small Cell Lung Cancer that are Epistatic or Synthetic Lethal with pRB Loss

The cofilin activity cycle in lamellipodia and invadopodia.
PubMed Identifier: 19862699
author list: Oser M, Condeelis J
published in: Journal of cellular biochemistry
information resource reference: The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem. 2009 Dec 15; 108(6):1252-62.
journal title abbreviation: J Cell Biochem
publication date: 2009-12-15T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.
PubMed Identifier: 21474314
author list: Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J
published in: Current biology : CB
information resource reference: A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol. 2011 Apr 26; 21(8):635-44.
journal title abbreviation: Curr Biol
publication date: 2011-04-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource