AIK1AminKassisAmin Iskandar Kassis, Ph.D.42.33594500000000-71.1029580000000010965Kassis, AminIskandar617/398-2400Professor of Radiology, Emerituscatalyst:eCommonsLogineCommons Loginprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor Receiptvivo:degreeEarneddegree earnedDepartmentDivisionvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1612502Muto MG, Finkler NJ, Kassis AI, Howes AE, Anderson LL, Lau CC, Zurawski VR, Weadock K, Tumeh SS, Lavin PGynecologic oncologyIntraperitoneal radioimmunotherapy of refractory ovarian carcinoma utilizing iodine-131-labeled monoclonal antibody OC125. Gynecol Oncol. 1992 Jun; 45(3):265-72.Gynecol Oncol1992-06-01T00:00:001992Intraperitoneal radioimmunotherapy of refractory ovarian carcinoma utilizing iodine-131-labeled monoclonal antibody OC125.11130010Kassis AI, Walicka MA, Adelstein SJActa oncologica (Stockholm, Sweden)Double-strand break yield following 125I decay--effects of DNA conformation. Acta Oncol. 2000; 39(6):721-6.Acta Oncol2000-01-01T00:00:002000Double-strand break yield following 125I decay--effects of DNA conformation.1629019Khawli LA, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologym-[125I]iodoaniline: a useful reagent for radiolabeling biotin. Int J Rad Appl Instrum B. 1992 Apr; 19(3):297-301.Int J Rad Appl Instrum B1992-04-01T00:00:001992m-[125I]iodoaniline: a useful reagent for radiolabeling biotin.19135549Yang Y, Adelstein SJ, Kassis AIDrug discovery todayTarget discovery from data mining approaches. Drug Discov Today. 2009 Feb; 14(3-4):147-54.Drug Discov Today2009-01-20T00:00:002009Target discovery from data mining approaches.8634994Muto MG, Kassis AICancerMonoclonal antibodies used in the detection and treatment of epithelial ovarian cancer. Cancer. 1995 Nov 15; 76(10 Suppl):2016-27.Cancer1995-11-15T00:00:001995Monoclonal antibodies used in the detection and treatment of epithelial ovarian cancer.Authorship 102491616857057Pospisil P, Iyer LK, Adelstein SJ, Kassis AIBMC bioinformaticsA combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics. 2006 Jul 20; 7:354.BMC Bioinformatics2006-07-20T00:00:002006A combined approach to data mining of textual and structured data to identify cancer-related targets.8218487Baranowska-Kortylewicz J, Kassis AIBioconjugate chemistryLabeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins. Bioconjug Chem. 1993 Jul-Aug; 4(4):300-4.Bioconjug Chem1993-07-01T00:00:001993Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins.8676198Kassis AI, Tumeh SS, Wen PY, Baranowska-Kortylewicz J, Van den Abbeele AD, Zimmerman RE, Carvalho PA, Garada BM, DeSisto WC, Bailey NO, Castronovo FP, Mariani G, Black PM, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicineIntratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor. J Nucl Med. 1996 Apr; 37(4 Suppl):19S-22S.J Nucl Med1996-04-01T00:00:001996Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor.18638445Balagurumoorthy P, Adelstein SJ, Kassis AIAnalytical biochemistryMethod to eliminate linear DNA from mixture containing nicked circular, supercoiled, and linear plasmid DNA. Anal Biochem. 2008 Oct 01; 381(1):172-4.Anal Biochem2008-07-04T00:00:002008Method to eliminate linear DNA from mixture containing nicked circular, supercoiled, and linear plasmid DNA.19061119Howell RW, Martin RF, Nikjoo H, Pomplun E, Terrissol M, Watanable R, Yasui L, Kassis AI, Adelstein SJInternational journal of radiation biologyMeeting overview. Int J Radiat Biol. 2008 Dec; 84(12):957-8.Int J Radiat Biol2008-12-01T00:00:002008Meeting overview.19061137Rebischung C, Hoffmann D, Stefani L, Desruet MD, Wang K, Adelstein SJ, Artignan X, Vincent F, Gauchez AS, Zhang H, Fagret D, Vuillez J, Kassis AI, Balosso JInternational journal of radiation biologyFirst human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus (125)IUdR. Int J Radiat Biol. 2008 Dec; 84(12):1123-9.Int J Radiat Biol2008-12-01T00:00:002008First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus (125)IUdR.12960195Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineCancer therapy with Auger electrons: are we almost there? J Nucl Med. 2003 Sep; 44(9):1479-81.J Nucl Med2003-09-01T00:00:002003Cancer therapy with Auger electrons: are we almost there?20632610Zhu X, Palmer MR, Makrigiorgos GM, Kassis AIMedical physicsSolid-tumor radionuclide therapy dosimetry: new paradigms in view of tumor microenvironment and angiogenesis. Med Phys. 2010 Jun; 37(6):2974-84.Med Phys2010-06-01T00:00:002010Solid-tumor radionuclide therapy dosimetry: new paradigms in view of tumor microenvironment and angiogenesis.2727257Kassis AI, Fayad F, Kinsey BM, Sastry KS, Adelstein SJRadiation researchRadiotoxicity of an 125I-labeled DNA intercalator in mammalian cells. Radiat Res. 1989 May; 118(2):283-94.Radiat Res1989-05-01T00:00:001989Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells.18987750Yang Y, Pospisil P, Iyer LK, Adelstein SJ, Kassis AIPloS oneIntegrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer. PLoS One. 2008; 3(11):e3661.PLoS One2008-11-06T00:00:002008Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer.2727274Makrigiorgos GM, Kassis AI, Baranowska-Kortylewicz J, McElvany KD, Welch MJ, Sastry KS, Adelstein SJRadiation researchRadiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine. Radiat Res. 1989 Jun; 118(3):532-44.Radiat Res1989-06-01T00:00:001989Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine.21106639Kassis AIRadiation protection dosimetryMolecular and cellular radiobiological effects of Auger emitting radionuclides. Radiat Prot Dosimetry. 2011 Feb; 143(2-4):241-7.Radiat Prot Dosimetry2010-11-24T00:00:002010Molecular and cellular radiobiological effects of Auger emitting radionuclides.21910833Yang Y, Wang K, Li W, Adelstein SJ, Kassis AIChemical biology & drug designHuman placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group. Chem Biol Drug Des. 2011 Dec; 78(6):923-31.Chem Biol Drug Des2011-10-24T00:00:002011Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group.17385903Wang K, Kirichian AM, Aowad AF, Adelstein SJ, Kassis AIBioconjugate chemistryEvaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative. Bioconjug Chem. 2007 May-Jun; 18(3):754-64.Bioconjug Chem2007-03-27T00:00:002007Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative.17390724Yasui LS, Chen K, Wang K, Jones TP, Caldwell J, Guse D, Kassis AIRadiation researchUsing Hoechst 33342 to target radioactivity to the cell nucleus. Radiat Res. 2007 Feb; 167(2):167-75.Radiat Res2007-02-01T00:00:002007Using Hoechst 33342 to target radioactivity to the cell nucleus.2366298Makrigiorgos GM, Adelstein SJ, Kassis AIJAMACellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. JAMA. 1990 Aug 01; 264(5):592-5.JAMA1990-08-01T00:00:001990Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates.21370101Yang Y, Adelstein SJ, Kassis AIMethods in molecular biology (Clifton, N.J.)Integrated bioinformatics analysis for cancer target identification. Methods Mol Biol. 2011; 719:527-45.Methods Mol Biol2011-01-01T00:00:002011Integrated bioinformatics analysis for cancer target identification.Authorship 10388811932174Tumeh SS, Carvalho PA, van den Abbeele AD, Maguire JH, Rauh DA, Neptune M, Kassis AIJournal of nuclear biology and medicine (Turin, Italy : 1991)Detection of focal infection by 111In-human polyclonal IgG. J Nucl Biol Med (1991). 1991 Jan-Mar; 35(1):4-9.J Nucl Biol Med (1991)1991-01-01T00:00:001991Detection of focal infection by 111In-human polyclonal IgG.1971836Whaley JM, Kassis AI, Kinsey BM, Adelstein SJ, Little JBInternational journal of radiation biologyMutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. Int J Radiat Biol. 1990 Jun; 57(6):1087-103.Int J Radiat Biol1990-06-01T00:00:001990Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells.12954118Adelstein SJ, Kassis AI, Bodei L, Mariani GCancer biotherapy & radiopharmaceuticalsRadiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy. Cancer Biother Radiopharm. 2003 Jun; 18(3):301-16.Cancer Biother Radiopharm2003-06-01T00:00:002003Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy.2686446Muto MG, Lepisto EM, Van den Abbeele AD, Knapp RC, Kassis AIAmerican journal of obstetrics and gynecologyInfluence of human antimurine antibody on CA 125 levels in patients with ovarian cancer undergoing radioimmunotherapy or immunoscintigraphy with murine monoclonal antibody OC 125. Am J Obstet Gynecol. 1989 Nov; 161(5):1206-12.Am J Obstet Gynecol1989-11-01T00:00:001989Influence of human antimurine antibody on CA 125 levels in patients with ovarian cancer undergoing radioimmunotherapy or immunoscintigraphy with murine monoclonal antibody OC 125.22732063Balagurumoorthy P, Xu X, Wang K, Adelstein SJ, Kassis AIInternational journal of radiation biologyEffect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol. 2012 Dec; 88(12):998-1008.Int J Radiat Biol2012-07-24T00:00:002012Effect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield.3490911Huberman MS, Lokich JJ, Hill T, Kaldany A, Kassis A, Price T, Moore C, Davis S, Kasulis P, Monaco APCancer immunology, immunotherapy : CIINon-human primate (baboon) anti-carcinoembryonic antigen antibody infusion in patients with metastatic adenocarcinoma. A phase I study. Cancer Immunol Immunother. 1986; 23(2):137-42.Cancer Immunol Immunother1986-01-01T00:00:001986Non-human primate (baboon) anti-carcinoembryonic antigen antibody infusion in patients with metastatic adenocarcinoma. A phase I study.8218488Baranowska-Kortylewicz J, Kassis AIBioconjugate chemistryLabeling of sulfhydryl groups in intact mammalian cells with coumarins. Bioconjug Chem. 1993 Jul-Aug; 4(4):305-7.Bioconjug Chem1993-07-01T00:00:001993Labeling of sulfhydryl groups in intact mammalian cells with coumarins.8676197Mariani G, Collecchi P, Baldassarri S, Di Luca L, Buralli S, Fontanini G, Baranowska-Kortylewicz J, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineTumor uptake and mitotic activity pattern of 5-[125I]iodo-2'- deoxyuridine after intravesical infusion in patients with bladder cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):16S-19S.J Nucl Med1996-04-01T00:00:001996Tumor uptake and mitotic activity pattern of 5-[125I]iodo-2'- deoxyuridine after intravesical infusion in patients with bladder cancer.Authorship 11231414969599Bodei L, Kassis AI, Adelstein SJ, Mariani GCancer biotherapy & radiopharmaceuticalsRadionuclide therapy with iodine-125 and other auger-electron-emitting radionuclides: experimental models and clinical applications. Cancer Biother Radiopharm. 2003 Dec; 18(6):861-77.Cancer Biother Radiopharm2003-12-01T00:00:002003Radionuclide therapy with iodine-125 and other auger-electron-emitting radionuclides: experimental models and clinical applications.Authorship 11203532384804Makrigiorgos GM, Ito S, Baranowska-Kortylewicz J, Vinter DW, Iqbal A, Van den Abbeele AD, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineInhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications. J Nucl Med. 1990 Aug; 31(8):1358-63.J Nucl Med1990-08-01T00:00:001990Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications.2613529Khawli LA, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologySynthesis of 125I labeled N-succinimidyl p-iodobenzoate for use in radiolabeling antibodies. Int J Rad Appl Instrum B. 1989; 16(7):727-33.Int J Rad Appl Instrum B1989-01-01T00:00:001989Synthesis of 125I labeled N-succinimidyl p-iodobenzoate for use in radiolabeling antibodies.2200860Mariani G, Kassis AI, Adelstein SJThe Journal of nuclear medicine and allied sciencesAntibody internalization by tumor cells: implications for tumor diagnosis and therapy. J Nucl Med Allied Sci. 1990 Jan-Mar; 34(1):51-4.J Nucl Med Allied Sci1990-01-01T00:00:001990Antibody internalization by tumor cells: implications for tumor diagnosis and therapy.2211057Janicek MJ, Van den Abbeele AD, Hollenberg NK, Kassis AI, Holman BL, Tumeh SSInvestigative radiologyPlatelet activation and aggregation after endothelial injury. Assessment with indium-111-labeled platelets and angiography. Invest Radiol. 1990 Sep; 25(9):988-93.Invest Radiol1990-09-01T00:00:001990Platelet activation and aggregation after endothelial injury. Assessment with indium-111-labeled platelets and angiography.17873139Sgouros G, Knox SJ, Joiner MC, Morgan WF, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineMIRD continuing education: Bystander and low dose-rate effects: are these relevant to radionuclide therapy? J Nucl Med. 2007 Oct; 48(10):1683-91.J Nucl Med2007-09-14T00:00:002007MIRD continuing education: Bystander and low dose-rate effects: are these relevant to radionuclide therapy?8075178Gangopadhyay A, Saravis CA, Kassis AIJournal of nuclear biology and medicine (Turin, Italy : 1991)Semipreparative isoelectrophoresis of DTPA-conjugated antibody leads to isolation of antibody isoforms with different immunoreactivities. J Nucl Biol Med (1991). 1994 Mar; 38(1):61-7.J Nucl Biol Med (1991)1994-03-01T00:00:001994Semipreparative isoelectrophoresis of DTPA-conjugated antibody leads to isolation of antibody isoforms with different immunoreactivities.8278579Speidel MT, Holmquist B, Kassis AI, Humm JL, Berman RM, Atcher RW, Hines JJ, Macklis RMRadiation researchMorphological, biochemical, and molecular changes in endothelial cells after alpha-particle irradiation. Radiat Res. 1993 Dec; 136(3):373-81.Radiat Res1993-12-01T00:00:001993Morphological, biochemical, and molecular changes in endothelial cells after alpha-particle irradiation.19061121Balagurumoorthy P, Wang K, Adelstein SJ, Kassis AIInternational journal of radiation biologyDNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: role of DNA topology. Int J Radiat Biol. 2008 Dec; 84(12):976-83.Int J Radiat Biol2008-12-01T00:00:002008DNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: role of DNA topology.3403319Macklis RM, Kaplan WD, Ferrara JL, Kinsey BM, Kassis AI, Burakoff SJInternational journal of radiation oncology, biology, physicsBiodistribution studies of anti-Thy 1.2 IgM immunoconjugates: implications for radioimmunotherapy. Int J Radiat Oncol Biol Phys. 1988 Aug; 15(2):383-9.Int J Radiat Oncol Biol Phys1988-08-01T00:00:001988Biodistribution studies of anti-Thy 1.2 IgM immunoconjugates: implications for radioimmunotherapy.815192Kassis AI, Tanner CEInternational journal for parasitologyThe role of complement in hydatid disease: in vitro studies. Int J Parasitol. 1976 Feb; 6(1):25-35.Int J Parasitol1976-02-01T00:00:001976The role of complement in hydatid disease: in vitro studies.8574807Gangopadhyay A, Saravis CA, van den Abbeele AD, Kassis AIThe quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)pI-dependent isolation of antibody isoforms by semipreparative isoelectric focusing. Q J Nucl Med. 1995 Jun; 39(2):129-33.Q J Nucl Med1995-06-01T00:00:001995pI-dependent isolation of antibody isoforms by semipreparative isoelectric focusing.8667069Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineTumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. J Nucl Med. 1996 Feb; 37(2):315-20.J Nucl Med1996-02-01T00:00:001996Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer.15653646Kassis AI, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicineRadiobiologic principles in radionuclide therapy. J Nucl Med. 2005 Jan; 46 Suppl 1:4S-12S.J Nucl Med2005-01-01T00:00:002005Radiobiologic principles in radionuclide therapy.16802869Kishikawa H, Wang K, Adelstein SJ, Kassis AIRadiation researchInhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123. Radiat Res. 2006 Jun; 165(6):688-94.Radiat Res2006-06-01T00:00:002006Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123.Authorship 12607518096857Makrigiorgos GM, Baranowska-Kortylewicz J, Bump E, Sahu SK, Berman RM, Kassis AIInternational journal of radiation biologyA method for detection of hydroxyl radicals in the vicinity of biomolecules using radiation-induced fluorescence of coumarin. Int J Radiat Biol. 1993 Apr; 63(4):445-58.Int J Radiat Biol1993-04-01T00:00:001993A method for detection of hydroxyl radicals in the vicinity of biomolecules using radiation-induced fluorescence of coumarin.Authorship 1068973679279Kassis AI, Warren KS, Mahmoud AACellular immunologyThe Schistosoma haematobium egg granuloma. Cell Immunol. 1978 Jul; 38(2):310-8.Cell Immunol1978-07-01T00:00:001978The Schistosoma haematobium egg granuloma.8166883Kinsey BM, Kassis AINuclear medicine and biologySynthesis and biological activity of 125I/127I-phenylboronic acid derivatives. Nucl Med Biol. 1993 Jan; 20(1):13-22.Nucl Med Biol1993-01-01T00:00:001993Synthesis and biological activity of 125I/127I-phenylboronic acid derivatives.8676199Mariani G, Di Sacco S, Volterrani D, Di Luca L, Buralli S, Di Stefano R, Baranowska-Kortylewicz J, Bonora D, Matteucci F, Ricci S, Bellina CR, Falcone A, Salvadori PA, Mosca F, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineTumor targeting by intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):22S-25S.J Nucl Med1996-04-01T00:00:001996Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer.3965653Kassis AI, Sastry KS, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicineIntracellular distribution and radiotoxicity of chromium-51 in mammalian cells: Auger-electron dosimetry. J Nucl Med. 1985 Jan; 26(1):59-67.J Nucl Med1985-01-01T00:00:001985Intracellular distribution and radiotoxicity of chromium-51 in mammalian cells: Auger-electron dosimetry.3312115Adelstein SJ, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologyRadiobiologic implications of the microscopic distribution of energy from radionuclides. Int J Rad Appl Instrum B. 1987; 14(3):165-9.Int J Rad Appl Instrum B1987-01-01T00:00:001987Radiobiologic implications of the microscopic distribution of energy from radionuclides.598449Kassis AI, Tanner CEExperimental parasitologyEchinococcus multilocularis: complement's role in vivo in hydatid disease. Exp Parasitol. 1977 Dec; 43(2):390-5.Exp Parasitol1977-12-01T00:00:001977Echinococcus multilocularis: complement's role in vivo in hydatid disease.10521930Kassis AI, Harapanhalli RS, Adelstein SJRadiation researchStrand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects. Radiat Res. 1999 Nov; 152(5):530-8.Radiat Res1999-11-01T00:00:001999Strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects.Microbiology11884502Kundra V, Mannting F, Jones AG, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineNoninvasive monitoring of somatostatin receptor type 2 chimeric gene transfer. J Nucl Med. 2002 Mar; 43(3):406-12.J Nucl Med2002-03-01T00:00:002002Noninvasive monitoring of somatostatin receptor type 2 chimeric gene transfer.8183987Makrigiorgos GM, Folkard M, Huang C, Bump E, Baranowska-Kortylewicz J, Sahu SK, Michael BD, Kassis AIRadiation researchQuantification of radiation-induced hydroxyl radicals within nucleohistones using a molecular fluorescent probe. Radiat Res. 1994 May; 138(2):177-85.Radiat Res1994-05-01T00:00:001994Quantification of radiation-induced hydroxyl radicals within nucleohistones using a molecular fluorescent probe.2345498Livni E, Ito S, Kassis AI, Elmaleh DRLipids(3H/14C)beta-methylheptadecanoic acid subcellular distribution and lipid incorporation in mouse heart. Lipids. 1990 Apr; 25(4):238-40.Lipids1990-04-01T00:00:001990(3H/14C)beta-methylheptadecanoic acid subcellular distribution and lipid incorporation in mouse heart.Authorship 10855323041410Ngwa W, Korideck H, Kassis AI, Kumar R, Sridhar S, Makrigiorgos GM, Cormack RANanomedicine : nanotechnology, biology, and medicineIn vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds. Nanomedicine. 2013 Jan; 9(1):25-7.Nanomedicine2012-10-02T00:00:002012In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds.7356746Kassis AI, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicineA rapid and reproducible method for the separation of cells from radioactive media. J Nucl Med. 1980 Jan; 21(1):88-90.J Nucl Med1980-01-01T00:00:001980A rapid and reproducible method for the separation of cells from radioactive media.7496371Foulon CF, Zhang YZ, Adelstein SJ, Kassis AIApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicineInstantaneous preparation of radiolabeled 5-iodo-2'-deoxyuridine. Appl Radiat Isot. 1995 Oct; 46(10):1039-46.Appl Radiat Isot1995-10-01T00:00:001995Instantaneous preparation of radiolabeled 5-iodo-2'-deoxyuridine.958420Kassis AI, Tanner CENatureNovel approach to the treatment of hydatid disease. Nature. 1976 Aug 12; 262(5569):588-9.Nature1976-08-12T00:00:001976Novel approach to the treatment of hydatid disease.8676195Kassis AI, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicinePreclinical animal studies with radioiododeoxyuridine. J Nucl Med. 1996 Apr; 37(4 Suppl):10S-12S.J Nucl Med1996-04-01T00:00:001996Preclinical animal studies with radioiododeoxyuridine.9092918Sahu SK, Kortylewicz ZP, Baranowska-Kortylewicz J, Taube RA, Adelstein SJ, Kassis AIRadiation researchStrand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA. Radiat Res. 1997 Apr; 147(4):401-8.Radiat Res1997-04-01T00:00:001997Strand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA.19061124Singh A, Yang Y, Adelstein SJ, Kassis AIInternational journal of radiation biologySynthesis and application of molecular probe for detection of hydroxyl radicals produced by Na(125)I and gamma-rays in aqueous solution. Int J Radiat Biol. 2008 Dec; 84(12):1001-10.Int J Radiat Biol2008-12-01T00:00:002008Synthesis and application of molecular probe for detection of hydroxyl radicals produced by Na(125)I and gamma-rays in aqueous solution.2897133Macklis RM, Kinsey BM, Kassis AI, Ferrara JL, Atcher RW, Hines JJ, Coleman CN, Adelstein SJ, Burakoff SJScience (New York, N.Y.)Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science. 1988 May 20; 240(4855):1024-6.Science1988-05-20T00:00:001988Radioimmunotherapy with alpha-particle-emitting immunoconjugates.3809393Kassis AI, Sastry KS, Adelstein SJRadiation researchKinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes. Radiat Res. 1987 Jan; 109(1):78-89.Radiat Res1987-01-01T00:00:001987Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes.7930827Makrigiorgos GM, Bump E, Huang C, Baranowska-Kortylewicz J, Kassis AIInternational journal of radiation biologyAccessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study. Int J Radiat Biol. 1994 Sep; 66(3):247-57.Int J Radiat Biol1994-09-01T00:00:001994Accessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study.D004583Concepts & Ideas1542690.877387ElectronsD007065Chemicals & Drugs191230.96245IdoxuridineAuthorship 127925D007457Chemicals & Drugs42010310.738589Iodine RadioisotopesD011355Chemicals & Drugs1592710.832679ProdrugsD011868Chemicals & Drugs2095020.860428RadioisotopesEmeritusMedicinePathologyRadiation OncologyRadiologySurgeryInfectious DiseasePulmonaryImmunologyHematologyBrigham and Women's HospitalHarvard Medical SchoolMassachusetts General HospitalMassachusetts Institute of TechnologyMNS5MichaelStarnbachMichael N. Starnbach, Ph.D.42.33594500000000-71.1029580000000058775Starnbach, MichaelProfessor of MicrobiologyHN32HungNguyenHung Nguyen, Ph.D.42.33594500000000-71.1029580000000074237Nguyen, HungInstructor in MedicineAV9AnnickVan Den AbbeeleAnnick Diane Van Den Abbeele, M.D.42.33789600000000-71.1072493000000074701Van Den Abbeele, AnnickProfessor of RadiologyGNM1GerassimosMakrigiorgosGerassimos M. Makrigiorgos, Ph.D.42.33510370000000-71.1061649000000083212Makrigiorgos, GerassimosProfessor of Radiation OncologyXZ38XupingZhuXuping Zhu, Ph.D.42.36241700000000-71.0689370000000041268Zhu, XupingAssistant Professor of RadiologyMAH17MarieHollenhorstMarie Alice Hollenhorst, M.D., Ph.D.42.33594500000000-71.1029580000000030963Hollenhorst, MarieAssistant Professor of MedicineHP15HaraldPaganettiHarald Paganetti, Ph.D.42.36241700000000-71.0689370000000047489Paganetti, HaraldProfessor of Radiation OncologyCZ37Cheng-ZhongZhangCheng-Zhong Zhang, Ph.D.42.33594500000000-71.1029580000000037327Zhang, Cheng-ZhongAssistant Professor of PathologyRSL4RobertLangerRobert S. Langer, Sc.D.42.36053900000000-71.0900740000000026380Langer, RobertSenior Lecturer on Surgery, Part-timePWK1PhilipKantoffPhilip Kantoff, M.D.42.33789600000000-71.1072493000000015015Kantoff, PhilipJerome and Nancy Kohlberg Professor of Medicine, EmeritusEJR2EricRubinEric Joseph Rubin, M.D., Ph.D.42.33594500000000-71.102958000000003893Rubin, EricProfessor of MedicineRW4RalphWeisslederRalph Weissleder, M.D., Ph.D.42.36125700000000-71.0655270000000048432Weissleder, RalphThrall Family Professor of RadiologyRKJ1RakeshJainRakesh K. Jain, Ph.D.42.36389900000000-71.0677780000000081300Jain, RakeshA. Werk Cook Professor of Radiation Oncology (Tumor Biology)SJA2JamesAdelsteinJames Adelstein, M.D., Ph.D.42.33686500000000-71.1039230000000082013Adelstein, JamesPaul C. Cabot Professor of Medical Biophysics, Emeritus11167selected publications6.091350.00200245543research areas7.220490.023707815coauthor of50.23779.6555860similar toAuthorship 1406483Authorship 1166791Authorship 1202522true1Professor of Radiology, EmeritusProfessor of Radiology, Emeritustrue1Professor of Radiation OncologyProfessor of Radiation Oncologytrue1Assistant Professor of RadiologyAssistant Professor of Radiologytrue1Professor of Radiation OncologyProfessor of Radiation Oncologytrue1Paul C. Cabot Professor of Medical Biophysics, EmeritusPaul C. Cabot Professor of Medical Biophysics, Emeritustrue1Jerome and Nancy Kohlberg Professor of Medicine, EmeritusJerome and Nancy Kohlberg Professor of Medicine, EmeritusAuthorship 1264407Authorship 1391995Authorship 1478314The American Board of Science in Nuclear Medicine2003The President's AwardThe Society of Nuclear Medicine2010The Loevinger-Berman AwardTakreem Organization2013Takreem Award for Scientific and Technological Achievement06/1976McGill UniversityMontreal, CanadaMcGill University, Immunology/ParasitologyPhDImmunology/Parasitology1978Case Western Reserve UniversityCleveland, OHCase Western Reserve University, ImmunoParasitologyImmunoParasitology1980Harvard Medical SchoolBoston, MAHarvard Medical School, Radiation BiologyRadiation Biology2003Harvard Medical SchoolBoston, MAHarvard Medical School, MedicineAM (Honorary)MedicineAuthorship 1210634Authorship 1273211Authorship 1380458Authorship 1548481Authorship 1570724Authorship 1396103Authorship 1378032Authorship 1502211Authorship 1873941Authorship 14048661034685549Van Neste L, Wojno KJ, Henao R, Mane S, Korman H, Hafron J, Kernen K, Tinawi-Aljundi R, Putzi M, Kassis AI, Kantoff PWCellsEvaluation of an RNAseq-Based Immunogenomic Liquid Biopsy Approach in Early-Stage Prostate Cancer. Cells. 2021 09 28; 10(10).Cells2021-09-28T00:00:002021Evaluation of an RNAseq-Based Immunogenomic Liquid Biopsy Approach in Early-Stage Prostate Cancer.Authorship 2100361true1Professor of RadiologyProfessor of Radiologytrue1Assistant Professor of PathologyAssistant Professor of PathologyAuthorship 1768428Authorship 1781453Authorship 278156true1A. Werk Cook Professor of Radiation Oncology (Tumor Biology)A. Werk Cook Professor of Radiation Oncology (Tumor Biology)true1Thrall Family Professor of RadiologyThrall Family Professor of Radiologytrue1Senior Lecturer on Surgery, Part-timeSenior Lecturer on Surgery, Part-timetrue1Professor of MicrobiologyProfessor of MicrobiologyAuthorship 435754Authorship 4527526Authorship 4790521Authorship 16168421738147400Van Neste L, Henao R, Wojno KJ, Signes J, DeHart J, Busta A, Marriott E, Willing M, Argentini A, Hurley PM, Korman H, Hafron J, Putzi M, Pieczonka CM, Karsh LI, Morris DS, Kassis AI, Kantoff PWThe Journal of urologyDevelopment and Optimization of a Subtraction-Normalized Immunocyte Profiling Signature for Prostate Cancer Active Surveillance Risk Stratification. J Urol. 2024 Mar; 211(3):415-425.J Urol2023-12-26T00:00:002023Development and Optimization of a Subtraction-Normalized Immunocyte Profiling Signature for Prostate Cancer Active Surveillance Risk Stratification.true1Assistant Professor of MedicineAssistant Professor of MedicineAuthorship 5441482true1Instructor in MedicineInstructor in Medicinetrue1Professor of MedicineProfessor of MedicineAuthorship 3556631Authorship 3894263Authorship 3925972Authorship 4639221Authorship 615191Authorship 3736051Authorship 855646Authorship 898995Authorship 201013Authorship 846296Authorship 21262813Authorship 2524323Authorship 2245802Authorship 2205151Authorship 2223421Authorship 2542643Authorship 2335721Authorship 2640571Authorship 2817863Authorship 4570593Authorship 1948481Authorship 3127914Authorship 168104Authorship 2337065Authorship 3037107Authorship 2589593Authorship 2480871Authorship 2896251Authorship 3992282Authorship 3118055Authorship 4424161Authorship 4054581Authorship 4980861Authorship 3664372Authorship 5649881Authorship 5751352Authorship 5767505Authorship 820605Authorship 2827267Authorship 2919191Authorship 314215Authorship 640942Authorship 657804Authorship 428444Authorship 3327921Authorship 354993Authorship 1759634Authorship 5030955Authorship 1673188Authorship 2813222Authorship 32211Authorship 649022Authorship 1954161Authorship 2515163Authorship 2566956Authorship 2837201Authorship 3013873Authorship 33846916Authorship 4288719Authorship 2875073Authorship 3119316Authorship 3550854Authorship 3735819Authorship 3797174Authorship 3824966Authorship 4162161Authorship 4320546Authorship 1274155Authorship 3389383Authorship 5281855Authorship 2795344Authorship 5421201Authorship 840297Authorship 2422242Authorship 4240072Authorship 4340313Authorship 2549521Authorship 2672923Authorship 2886635Authorship 3380025Authorship 3704466Authorship 4674232Authorship 476457Authorship 502523Authorship 5688653Authorship 162761Authorship 5737233Authorship 4664395Authorship 4668704Authorship 4198263Authorship 2769852Authorship 3058304Authorship 4700588Authorship 4768263Authorship 4067913Authorship 4419221Authorship 5486221Authorship 3013411Authorship 3255682Authorship 3885256Authorship 4470671Authorship 5304734Authorship 781825Authorship 3660411Authorship 3686277Authorship 3952503Authorship 4453294Authorship 4484502Authorship 4723405Authorship 481414Authorship 4894282Authorship 5236932Authorship 5612407Authorship 857715Authorship 946931Authorship 4295631Authorship 4909453Authorship 5108735Authorship 7017072Assistant Professor0Full Professor4Instructor3LecturerAuthorship 763551Authorship 5657653Authorship 6703812005-12-31KASSIS, AMIN I2001-01-01RADIODIAGNOSIS &RADIOTHERAPY OF LUNG CANCER METASTASESR01CA0896482013-04-30KASSIS, AMIN I1977-05-01Therapeutic/Toxic Effects of Electron Emitting NuclidesR01CA0155232012-08-31KASSIS, AMIN I2009-09-30Detection of Prostate Cancer Genomic Signatures in BloodRC1CA1458642012-03-31KASSIS, AMIN I2010-04-09Novel Blood Assay for Lung Cancer DetectionR21CA143101Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 3248201Authorship 3753903Authorship 4720714Authorship 5107902Authorship 2028054Authorship 2150041Authorship 3678922Authorship 3964605Authorship 5017204Authorship 52703011Authorship 910118941394Harapanhalli RS, McLaughlin LW, Howell RW, Rao DV, Adelstein SJ, Kassis AIJournal of medicinal chemistry[125I/127I]iodoHoechst 33342: synthesis, DNA binding, and biodistribution. J Med Chem. 1996 Nov 22; 39(24):4804-9.J Med Chem1996-11-22T00:00:001996[125I/127I]iodoHoechst 33342: synthesis, DNA binding, and biodistribution.1279075Kassis AI, Goh SL, Tanner CEInternational journal for parasitologyLesions induced by complement in vitro on the protoscoleces of Echinococcus multilocularis: a study by electron microscopy. Int J Parasitol. 1976 Jun; 6(3):199-211.Int J Parasitol1976-06-01T00:00:001976Lesions induced by complement in vitro on the protoscoleces of Echinococcus multilocularis: a study by electron microscopy.9457893Walicka MA, Adelstein SJ, Kassis AIRadiation researchIndirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival. Radiat Res. 1998 Feb; 149(2):142-6.Radiat Res1998-02-01T00:00:001998Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival.1885272Janicek MJ, Van den Abbeele AD, DeSisto WC, Kassis AI, Holman BL, Tumeh SS, Hollenberg NKInvestigative radiologyEmbolization of platelets after endothelial injury to the aorta in rabbits. Assessment with 111indium-labeled platelets and angiography. Invest Radiol. 1991 Jul; 26(7):655-9.Invest Radiol1991-07-01T00:00:001991Embolization of platelets after endothelial injury to the aorta in rabbits. Assessment with 111indium-labeled platelets and angiography.15764406Kassis AI, Kirichian AM, Wang K, Semnani ES, Adelstein SJInternational journal of radiation biologyTherapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):941-6.Int J Radiat Biol2004-11-01T00:00:002004Therapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis.16296803Kassis AIExpert opinion on drug deliveryRadiotargeting agents for cancer therapy. Expert Opin Drug Deliv. 2005 Nov; 2(6):981-91.Expert Opin Drug Deliv2005-11-01T00:00:002005Radiotargeting agents for cancer therapy.9801063Maulik G, Kassis AI, Savvides P, Makrigiorgos GMFree radical biology & medicineFluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation. Free Radic Biol Med. 1998 Oct; 25(6):645-53.Free Radic Biol Med1998-10-01T00:00:001998Fluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation.15070063Kassis AIHuman & experimental toxicologyIn vivo validation of the bystander effect. Hum Exp Toxicol. 2004 Feb; 23(2):71-3.Hum Exp Toxicol2004-02-01T00:00:002004In vivo validation of the bystander effect.15764395Urashima T, Wang K, Adelstein SJ, Kassis AIInternational journal of radiation biologyActivation of diverse pathways to apoptosis by (125)IdUrd and gamma-photon exposure. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):867-74.Int J Radiat Biol2004-11-01T00:00:002004Activation of diverse pathways to apoptosis by (125)IdUrd and gamma-photon exposure.9004775Mariani G, Di Sacco S, Bonini R, Di Luca L, Buralli S, Bonora D, Ricci S, Baranowska-Kortylewicz J, Adelstein SJ, Falcone A, Kassis AIActa oncologica (Stockholm, Sweden)Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer. Acta Oncol. 1996; 35(7):941-5.Acta Oncol1996-01-01T00:00:001996Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer.10622264Walicka MA, Ding Y, Roy AM, Harapanhalli RS, Adelstein SJ, Kassis AIInternational journal of radiation biologyCytotoxicity of [125I]iodoHoechst 33342: contribution of scavengeable effects. Int J Radiat Biol. 1999 Dec; 75(12):1579-87.Int J Radiat Biol1999-12-01T00:00:001999Cytotoxicity of [125I]iodoHoechst 33342: contribution of scavengeable effects.200 Longwood AveHarvard Medical SchoolRadiology, Armenise Bldg200 Longwood AveBoston02115MA17332350Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AICancer researchComputational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res. 2007 Mar 01; 67(5):2197-205.Cancer Res2007-03-01T00:00:002007Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors.11906274Ho NH, Harapanhalli RS, Dahman BA, Chen K, Wang K, Adelstein SJ, Kassis AIBioconjugate chemistrySynthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy. Bioconjug Chem. 2002 Mar-Apr; 13(2):357-64.Bioconjug Chem2002-03-01T00:00:002002Synthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy.1569491Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineThe MIRD approach: remembering the limitations. J Nucl Med. 1992 May; 33(5):781-2.J Nucl Med1992-05-01T00:00:001992The MIRD approach: remembering the limitations.9728654Walicka MA, Vaidyanathan G, Zalutsky MR, Adelstein SJ, Kassis AIRadiation researchSurvival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiat Res. 1998 Sep; 150(3):263-8.Radiat Res1998-09-01T00:00:001998Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211.16881734Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AIRadiation researchMechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst. Radiat Res. 2006 Aug; 166(2):333-44.Radiat Res2006-08-01T00:00:002006Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst.9952301Kassis AI, Harapanhalli RS, Adelstein SJRadiation researchComparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125. Radiat Res. 1999 Feb; 151(2):167-76.Radiat Res1999-02-01T00:00:001999Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125.10994732Mariani G, Bodei L, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineEmerging roles for radiometabolic therapy of tumors based on auger electron emission. J Nucl Med. 2000 Sep; 41(9):1519-21.J Nucl Med2000-09-01T00:00:002000Emerging roles for radiometabolic therapy of tumors based on auger electron emission.1542718Makrigiorgos GM, Berman RM, Baranowska-Kortylewicz J, Bump E, Humm JL, Adelstein SJ, Kassis AIRadiation researchDNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125. Radiat Res. 1992 Mar; 129(3):309-14.Radiat Res1992-03-01T00:00:001992DNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125.2809750Makrigiorgos GM, Adelstein SJ, Kassis AIJournal of nuclear medicine : official publication, Society of Nuclear MedicineLimitations of conventional internal dosimetry at the cellular level. J Nucl Med. 1989 Nov; 30(11):1856-64.J Nucl Med1989-11-01T00:00:001989Limitations of conventional internal dosimetry at the cellular level.3309314Kinsey BM, Kassis AI, Fayad F, Layne WW, Adelstein SJJournal of medicinal chemistrySynthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123. J Med Chem. 1987 Oct; 30(10):1757-61.J Med Chem1987-10-01T00:00:001987Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123.1629018Khawli LA, van den Abbeele AD, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologyN-(m-[125I]iodophenyl)maleimide: an agent for high yield radiolabeling of antibodies. Int J Rad Appl Instrum B. 1992 Apr; 19(3):289-95.Int J Rad Appl Instrum B1992-04-01T00:00:001992N-(m-[125I]iodophenyl)maleimide: an agent for high yield radiolabeling of antibodies.1740707Kassis AI, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear MedicineDoes nonuniformity of dose have implications for radiation protection? J Nucl Med. 1992 Mar; 33(3):384-7.J Nucl Med1992-03-01T00:00:001992Does nonuniformity of dose have implications for radiation protection?1840093Kassis AI, Guptill WE, Taube RA, Adelstein SJJournal of nuclear biology and medicine (Turin, Italy : 1991)Radiotoxicity of 5-[125I]iodo-2'-deoxyuridine in mammalian cells following treatment with 5-fluoro-2'-deoxyuridine. J Nucl Biol Med (1991). 1991 Jul-Sep; 35(3):167-73.J Nucl Biol Med (1991)1991-07-01T00:00:001991Radiotoxicity of 5-[125I]iodo-2'-deoxyuridine in mammalian cells following treatment with 5-fluoro-2'-deoxyuridine.8889487Chakrabarti S, Mahmood A, Kassis AI, Bump EA, Jones AG, Makrigiorgos GMFree radical researchGeneration of hydroxyl radicals by nucleohistone-bound metal-adriamycin complexes. Free Radic Res. 1996 Sep; 25(3):207-20.Free Radic Res1996-09-01T00:00:001996Generation of hydroxyl radicals by nucleohistone-bound metal-adriamycin complexes.9004774Kassis AI, Adelstein SJActa oncologica (Stockholm, Sweden)5-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol. 1996; 35(7):935-9.Acta Oncol1996-01-01T00:00:0019965-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats.Authorship 981722428512969Zhu X, Palmer MR, Makrigiorgos GM, Kassis AIMedical physicsSolid-tumor radionuclide therapy dosimetry: New paradigms in view of tumor microenvironment and angiogenesis. Med Phys. 2010 Jun; 37(6Part1):2974-2984.Med Phys2010-06-01T00:00:002010Solid-tumor radionuclide therapy dosimetry: New paradigms in view of tumor microenvironment and angiogenesis.17127180Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AINuclear medicine and biologyInduction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. Nucl Med Biol. 2006 Nov; 33(8):1055-63.Nucl Med Biol2006-11-01T00:00:002006Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure.9457892Walicka MA, Adelstein SJ, Kassis AIRadiation researchIndirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks. Radiat Res. 1998 Feb; 149(2):134-41.Radiat Res1998-02-01T00:00:001998Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks.9669385Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJJournal of nuclear medicine : official publication, Society of Nuclear Medicine5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med. 1998 Jul; 39(7):1148-54.J Nucl Med1998-07-01T00:00:0019985-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats.12368480Xue LY, Butler NJ, Makrigiorgos GM, Adelstein SJ, Kassis AIProceedings of the National Academy of Sciences of the United States of AmericaBystander effect produced by radiolabeled tumor cells in vivo. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13765-70.Proc Natl Acad Sci U S A2002-10-04T00:00:002002Bystander effect produced by radiolabeled tumor cells in vivo.21439257Yang Y, Adelstein SJ, Kassis AIMolecular imagingGeneral approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles. Mol Imaging. 2011 Apr; 10(2):123-34.Mol Imaging2011-04-01T00:00:002011General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles.1938564Baranowska-Kortylewicz J, Makrigiorgos GM, Van den Abbeele AD, Berman RM, Adelstein SJ, Kassis AIInternational journal of radiation oncology, biology, physics5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1541-51.Int J Radiat Oncol Biol Phys1991-11-01T00:00:0019915-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model.2090794Kassis AIThe Journal of nuclear medicine and allied sciences5-123I/125I-iodo-2'-deoxyuridine for cancer diagnosis and therapy. J Nucl Med Allied Sci. 1990 Oct-Dec; 34(4):299-303.J Nucl Med Allied Sci1990-10-01T00:00:0019905-123I/125I-iodo-2'-deoxyuridine for cancer diagnosis and therapy.9622552Harapanhalli RS, Roy AM, Adelstein SJ, Kassis AIJournal of medicinal chemistry[125I/127I/131I]Iodorhodamine: synthesis, cellular localization, and biodistribution in athymic mice bearing human tumor xenografts and comparison with [99mTc]hexakis(2-methoxyisobutylisonitrile). J Med Chem. 1998 Jun 04; 41(12):2111-7.J Med Chem1998-06-04T00:00:001998[125I/127I/131I]Iodorhodamine: synthesis, cellular localization, and biodistribution in athymic mice bearing human tumor xenografts and comparison with [99mTc]hexakis(2-methoxyisobutylisonitrile).2341291Kinsey BM, Fayad F, Venkateshan CN, Adelstein SJ, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologySynthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. Int J Rad Appl Instrum B. 1990; 17(3):341-6.Int J Rad Appl Instrum B1990-01-01T00:00:001990Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine.2387541Muto MG, Finkler NJ, Kassis AI, Lepisto EM, Knapp RCGynecologic oncologyHuman anti-murine antibody responses in ovarian cancer patients undergoing radioimmunotherapy with the murine monoclonal antibody OC-125. Gynecol Oncol. 1990 Aug; 38(2):244-8.Gynecol Oncol1990-08-01T00:00:001990Human anti-murine antibody responses in ovarian cancer patients undergoing radioimmunotherapy with the murine monoclonal antibody OC-125.2187215Makrigiorgos G, Adelstein SJ, Kassis AIRadiation and environmental biophysicsAuger electron emitters: insights gained from in vitro experiments. Radiat Environ Biophys. 1990; 29(2):75-91.Radiat Environ Biophys1990-01-01T00:00:001990Auger electron emitters: insights gained from in vitro experiments.9464477Chakrabarti S, Kassis AI, Slayter HS, Bump EA, Sahu SK, Makrigiorgos GMInternational journal of radiation biologyContinuous detection of radiation or metal generated hydroxyl radicals within core chromatin particles. Int J Radiat Biol. 1998 Jan; 73(1):53-63.Int J Radiat Biol1998-01-01T00:00:001998Continuous detection of radiation or metal generated hydroxyl radicals within core chromatin particles.11018618Goharderakhshan RZ, Grossfeld GD, Kassis A, Shinohara K, Roach M, Carroll PRUrologyAdditional treatments and reimbursement rates associated with prostate cancer treatment for patients undergoing radical prostatectomy, interstitial brachytherapy, and external beam radiotherapy. Urology. 2000 Oct 01; 56(4):622-6.Urology2000-10-01T00:00:002000Additional treatments and reimbursement rates associated with prostate cancer treatment for patients undergoing radical prostatectomy, interstitial brachytherapy, and external beam radiotherapy.18662557Kassis AISeminars in nuclear medicineTherapeutic radionuclides: biophysical and radiobiologic principles. Semin Nucl Med. 2008 Sep; 38(5):358-66.Semin Nucl Med2008-09-01T00:00:002008Therapeutic radionuclides: biophysical and radiobiologic principles.2379179Kassis AI, Van den Abbeele AD, Wen PY, Baranowska-Kortylewicz J, Aaronson RA, DeSisto WC, Lampson LA, Black PM, Adelstein SJCancer researchSpecific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans. Cancer Res. 1990 Aug 15; 50(16):5199-203.Cancer Res1990-08-15T00:00:001990Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans.2715008Mariani G, Abbeele AD, Venkateshan CN, Kaldany A, Ito S, Adelstein SJ, Kassis AIInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologyMonoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications. Int J Rad Appl Instrum B. 1989; 16(2):147-50.Int J Rad Appl Instrum B1989-01-01T00:00:001989Monoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications.3108200Kassis AI, Taube RAInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biologyEfficient radiolabeling of mammalian cells using 111In-tagged liposomes. 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J Immunol Methods. 1987 Feb 11; 96(2):195-9.J Immunol Methods1987-02-11T00:00:001987HPLC analysis of the dissociation and recombination of rabbit immunoglobulin G.17172404Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AIMolecular cancer therapeuticsIn silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy. Mol Cancer Ther. 2006 Dec; 5(12):3001-13.Mol Cancer Ther2006-12-01T00:00:002006In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy.17256924Chen K, Aowad AF, Adelstein SJ, Kassis AIJournal of medicinal chemistryMolecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs. 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