DPC4DavidCoreyDavid P. Corey, Ph.D.42.33602040000000-71.1034325000000010166Corey, DavidP.617/432-2506Bertarelli Professor of Translational Medical Sciencecatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10069328Holt JR, Corey DPNeuronIon channel defects in hereditary hearing loss. Neuron. 1999 Feb; 22(2):217-9.Neuron1999-02-01T00:00:001999Ion channel defects in hereditary hearing loss.10644435Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XOGenomicsThe TOR1A (DYT1) gene family and its role in early onset torsion dystonia. Genomics. 1999 Dec 15; 62(3):377-84.Genomics1999-12-15T00:00:001999The TOR1A (DYT1) gene family and its role in early onset torsion dystonia.12040033Rehm HL, Zhang DS, Brown MC, Burgess B, Halpin C, Berger W, Morton CC, Corey DP, Chen ZYThe Journal of neuroscience : the official journal of the Society for NeuroscienceVascular defects and sensorineural deafness in a mouse model of Norrie disease. J Neurosci. 2002 Jun 01; 22(11):4286-92.J Neurosci2002-06-01T00:00:002002Vascular defects and sensorineural deafness in a mouse model of Norrie disease.1691005Barres BA, Koroshetz WJ, Swartz KJ, Chun LL, Corey DPNeuronIon channel expression by white matter glia: the O-2A glial progenitor cell. Neuron. 1990 Apr; 4(4):507-24.Neuron1990-04-01T00:00:001990Ion channel expression by white matter glia: the O-2A glial progenitor cell.7206783Corey DP, Hudspeth AJJournal of neuroscience methodsMechanical stimulation and micromanipulation with piezoelectric bimorph elements. J Neurosci Methods. 1980 Dec; 3(2):183-202.J Neurosci Methods1980-12-01T00:00:001980Mechanical stimulation and micromanipulation with piezoelectric bimorph elements.15922584Lin SY, Corey DPCurrent opinion in neurobiologyTRP channels in mechanosensation. Curr Opin Neurobiol. 2005 Jun; 15(3):350-7.Curr Opin Neurobiol2005-06-01T00:00:002005TRP channels in mechanosensation.9786971García JA, Yee AG, Gillespie PG, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceLocalization of myosin-Ibeta near both ends of tip links in frog saccular hair cells. J Neurosci. 1998 Nov 01; 18(21):8637-47.J Neurosci1998-11-01T00:00:001998Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cells.23135401Sotomayor M, Weihofen WA, Gaudet R, Corey DPNatureStructure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 2012 Dec 06; 492(7427):128-32.Nature2012-11-07T00:00:002012Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.23467356Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KNThe Journal of neuroscience : the official journal of the Society for NeuroscienceNoddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells. J Neurosci. 2013 Mar 06; 33(10):4395-404.J Neurosci2013-03-06T00:00:002013Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.17585304Christensen AP, Corey DPNature reviews. NeuroscienceTRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci. 2007 Jul; 8(7):510-21.Nat Rev Neurosci2007-07-01T00:00:002007TRP channels in mechanosensation: direct or indirect activation?2236074Shepherd GM, Corey DP, Block SMProceedings of the National Academy of Sciences of the United States of AmericaActin cores of hair-cell stereocilia support myosin motility. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8627-31.Proc Natl Acad Sci U S A1990-11-01T00:00:001990Actin cores of hair-cell stereocilia support myosin motility.17961150Scheffer D, Sage C, Plazas PV, Huang M, Wedemeyer C, Zhang DS, Chen ZY, Elgoyhen AB, Corey DP, Pingault VJournal of neurochemistryThe a1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the ? subunit in hair cells. J Neurochem. 2007 Dec; 103(6):2651-64.J Neurochem2007-12-01T00:00:002007The a1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the ? subunit in hair cells.22158513Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BSNature neuroscienceTRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci. 2011 Dec 11; 15(1):70-80.Nat Neurosci2011-12-11T00:00:002011TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.12764092Meyers JR, MacDonald RB, Duggan A, Lenzi D, Standaert DG, Corwin JT, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceLighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci. 2003 May 15; 23(10):4054-65.J Neurosci2003-05-15T00:00:002003Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels.16901942Corey DPThe Journal of physiologyWhat is the hair cell transduction channel? J Physiol. 2006 Oct 01; 576(Pt 1):23-8.J Physiol2006-08-10T00:00:002006What is the hair cell transduction channel?8396455Cannon SC, Brown RH, Corey DPBiophysical journalTheoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels. Biophys J. 1993 Jul; 65(1):270-88.Biophys J1993-07-01T00:00:001993Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels.17826772Scheffer D, Sage C, Corey DP, Pingault VFEBS lettersGene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. FEBS Lett. 2007 Oct 02; 581(24):4651-6.FEBS Lett2007-09-04T00:00:002007Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.18930819Corey DP, Movshon JACurrent opinion in neurobiologySensory systems: from molecules to percepts. Curr Opin Neurobiol. 2008 Aug; 18(4):355-6.Curr Opin Neurobiol2008-10-23T00:00:002008Sensory systems: from molecules to percepts.Authorship 1082682630015805Krey JF, Scheffer DI, Choi D, Reddy A, David LL, Corey DP, Barr-Gillespie PGScientific dataMass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells. Sci Data. 2018 07 17; 5:180128.Sci Data2018-07-17T00:00:002018Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells.16648263Sage C, Huang M, Vollrath MA, Brown MC, Hinds PW, Corey DP, Vetter DE, Chen ZYProceedings of the National Academy of Sciences of the United States of AmericaEssential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7345-50.Proc Natl Acad Sci U S A2006-04-28T00:00:002006Essential role of retinoblastoma protein in mammalian hair cell development and hearing.2023-07-31COREY, DAVID P2018-08-01Gene Therapy for Hearing and Balance DisordersR01DC016932Principal Investigator30138589Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JRNeuronTMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 2018 08 22; 99(4):736-753.e6.Neuron2018-08-22T00:00:002018TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.2560639Barres BA, Chun LL, Corey DPNeuronGlial and neuronal forms of the voltage-dependent sodium channel: characteristics and cell-type distribution. Neuron. 1989 Apr; 2(4):1375-88.Neuron1989-04-01T00:00:001989Glial and neuronal forms of the voltage-dependent sodium channel: characteristics and cell-type distribution.8685718Corey DP, García-Añoveros JScience (New York, N.Y.)Mechanosensation and the DEG/ENaC ion channels. Science. 1996 Jul 19; 273(5273):323-4.Science1996-07-19T00:00:001996Mechanosensation and the DEG/ENaC ion channels.Authorship 117808219259066Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, García-Añoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XOMolecular therapy : the journal of the American Society of Gene TherapyMutant sodium channel for tumor therapy. Mol Ther. 2009 May; 17(5):810-9.Mol Ther2009-03-03T00:00:002009Mutant sodium channel for tumor therapy.Authorship 1089610132662191Shepherd GM, Barres BA, Corey DPProceedings of the National Academy of Sciences of the United States of America"Bundle blot" purification and initial protein characterization of hair cell stereocilia. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4973-7.Proc Natl Acad Sci U S A1989-07-01T00:00:001989"Bundle blot" purification and initial protein characterization of hair cell stereocilia.19369549Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CLThe Journal of neuroscience : the official journal of the Society for NeuroscienceTRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci. 2009 Apr 15; 29(15):4808-19.J Neurosci2009-04-15T00:00:002009TRPA1 modulates mechanotransduction in cutaneous sensory neurons.Authorship 1096054130291150Corey DP, Akyuz N, Holt JRCold Spring Harbor perspectives in medicineFunction and Dysfunction of TMC Channels in Inner Ear Hair Cells. Cold Spring Harb Perspect Med. 2019 10 01; 9(10).Cold Spring Harb Perspect Med2019-10-01T00:00:002019Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.17942735Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian AThe Journal of neuroscience : the official journal of the Society for NeuroscienceAn ion channel essential for sensing chemical damage. J Neurosci. 2007 Oct 17; 27(42):11412-5.J Neurosci2007-10-17T00:00:002007An ion channel essential for sensing chemical damage.10837217Duggan A, García-Añoveros J, Corey DPCurrent biology : CBInsect mechanoreception: what a long, strange TRP it's been. Curr Biol. 2000 May 18; 10(10):R384-7.Curr Biol2000-05-18T00:00:002000Insect mechanoreception: what a long, strange TRP it's been.7568224Hasson T, Heintzelman MB, Santos-Sacchi J, Corey DP, Mooseker MSProceedings of the National Academy of Sciences of the United States of AmericaExpression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9815-9.Proc Natl Acad Sci U S A1995-10-10T00:00:001995Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.16214875Cheung EL, Corey DPBiophysical journalCa2+ changes the force sensitivity of the hair-cell transduction channel. Biophys J. 2006 Jan 01; 90(1):124-39.Biophys J2005-10-07T00:00:002005Ca2+ changes the force sensitivity of the hair-cell transduction channel.Authorship 11222181930581889György B, Meijer EJ, Ivanchenko MV, Tenneson K, Emond F, Hanlon KS, Indzhykulian AA, Volak A, Karavitaki KD, Tamvakologos PI, Vezina M, Berezovskii VK, Born RT, O'Brien M, Lafond JF, Arsenijevic Y, Kenna MA, Maguire CA, Corey DPMolecular therapy. Methods & clinical developmentGene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate. Mol Ther Methods Clin Dev. 2019 Jun 14; 13:1-13.Mol Ther Methods Clin Dev2018-11-20T00:00:002018Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate.8805263García-Añoveros J, Corey DPCurrent biology : CBTouch at the molecular level. Mechanosensation. Curr Biol. 1996 May 01; 6(5):541-3.Curr Biol1996-05-01T00:00:001996Touch at the molecular level. Mechanosensation.9390509Gillespie PG, Corey DPNeuronMyosin and adaptation by hair cells. Neuron. 1997 Nov; 19(5):955-8.Neuron1997-11-01T00:00:001997Myosin and adaptation by hair cells.14872099Sukharev S, Corey DPScience's STKE : signal transduction knowledge environmentMechanosensitive channels: multiplicity of families and gating paradigms. Sci STKE. 2004 Feb 03; 2004(219):re4.Sci STKE2004-02-03T00:00:002004Mechanosensitive channels: multiplicity of families and gating paradigms.14970196Kamm C, Boston H, Hewett J, Wilbur J, Corey DP, Hanson PI, Ramesh V, Breakefield XOThe Journal of biological chemistryThe early onset dystonia protein torsinA interacts with kinesin light chain 1. J Biol Chem. 2004 May 07; 279(19):19882-92.J Biol Chem2004-02-17T00:00:002004The early onset dystonia protein torsinA interacts with kinesin light chain 1.17428178Vollrath MA, Kwan KY, Corey DPAnnual review of neuroscienceThe micromachinery of mechanotransduction in hair cells. Annu Rev Neurosci. 2007; 30:339-65.Annu Rev Neurosci2007-01-01T00:00:002007The micromachinery of mechanotransduction in hair cells.Authorship 10784948105077Cannon SC, Corey DPThe Journal of physiologyLoss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis. J Physiol. 1993 Jul; 466:501-20.J Physiol1993-07-01T00:00:001993Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis.Otolaryngology Head and Neck SurgeryAuthorship 1165903D006199Anatomy621910.849152Hair Cells, Auditory, InnerD007758Anatomy1344210.714633Ear, InnerD040542Physiology2505380.660717Mechanotransduction, CellularD006309Physiology1984780.73124HearingD006198Anatomy893610.792896Hair Cells, AuditoryEmeritusNeurobiologyNeurologyBoston Children's HospitalHarvard Medical SchoolMassachusetts Eye and Ear InfirmaryMassachusetts General HospitalML36MohiniLutchmanMohini Lutchman, Ph.D.42.33602040000000-71.1034325000000013296Lutchman, MohiniLecturer on NeurobiologyASE4AlbertEdgeAlbert Edge, Ph.D.42.36253200000000-71.0703100000000060563Edge, AlbertEaton-Peabody Professor of Otolaryngology Head and Neck SurgeryMCL2M.LibermanM. Charles Liberman, Ph.D.42.36253200000000-71.0703100000000052784Liberman, M.Harold F. Schuknecht Professor of Otology and LaryngologyDH40DavidHarminDavid A. Harmin, Ph.D.42.33602040000000-71.1034325000000045186Harmin, DavidInstructor in NeurobiologyJBN1JosephNadolJoseph Bronislaw Nadol, Jr., M.D.42.36253200000000-71.070310000000002550Nadol, JosephWalter Augustus Lecompte Professor of Otology and Laryngology, EmeritusSLH2LindaHuLinda S. Hu, M.D.42.33602040000000-71.1034325000000041188Hu, LindaResearch Associate in NeurobiologyJRH2JeffreyHoltJeffrey R. Holt, Ph.D.15610Holt, JeffreyProfessor of Otolaryngology Head and Neck SurgeryAAI3ArturIndzhykulianArtur Indzhykulian, Ph.D.105810Indzhykulian, ArturAssistant Professor of Otolaryngology Head and Neck SurgeryRW30RachelWilsonRachel Wilson, Ph.D.42.33602040000000-71.103432500000005492Wilson, RachelJoseph B. Martin Professor of Basic Research in the Field of NeurobiologyCJW2CharlesWeitzCharles J. Weitz, M.D., Ph.D.42.33602040000000-71.1034325000000067257Weitz, CharlesRobert Henry Pfeiffer Professor of NeurobiologyZC3Zheng-YiChenZheng-Yi Chen, D.Phil.42.36253200000000-71.0703100000000077237Chen, Zheng-YiAssociate Professor of Otolaryngology Head and Neck SurgeryCAM36CaseyMaguireCasey A. Maguire, Ph.D.42.37730000000000-71.0525000000000086792Maguire, CaseyAssociate Professor of NeurologyAuthorship 11659351531270503György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DPNature medicineAllele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nat Med. 2019 07; 25(7):1123-1130.Nat Med2019-07-03T00:00:002019Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.11147selected publications6.658380.00115645565research areas5.506910.013775130coauthor of119.94112.588860similar toDEC3DavidClaphamDavid Clapham, M.D., Ph.D.42.33790000000000-71.1059000000000011196Clapham, DavidAldo R. Castaneda Professor of Cardiovascular Research, EmeritusAuthorship 14414910Authorship 1182585631444330Wu X, Ivanchenko MV, Al Jandal H, Cicconet M, Indzhykulian AA, Corey DPNature communicationsPKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nat Commun. 2019 08 23; 10(1):3801.Nat Commun2019-08-23T00:00:002019PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing.Authorship 1428258Authorship 11938611431570731Hanlon KS, Kleinstiver BP, Garcia SP, Zaborowski MP, Volak A, Spirig SE, Muller A, Sousa AA, Tsai SQ, Bengtsson NE, Lööv C, Ingelsson M, Chamberlain JS, Corey DP, Aryee MJ, Joung JK, Breakefield XO, Maguire CA, György BNature communicationsHigh levels of AAV vector integration into CRISPR-induced DNA breaks. Nat Commun. 2019 09 30; 10(1):4439.Nat Commun2019-09-30T00:00:002019High levels of AAV vector integration into CRISPR-induced DNA breaks.Authorship 1217781true1Instructor in NeurobiologyInstructor in Neurobiologytrue1Aldo R. Castaneda Professor of Cardiovascular Research, EmeritusAldo R. Castaneda Professor of Cardiovascular Research, Emeritustrue1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Robert Henry Pfeiffer Professor of NeurobiologyRobert Henry Pfeiffer Professor of Neurobiologytrue1Research Associate in NeurobiologyResearch Associate in NeurobiologyAuthorship 1162183Authorship 1332701Authorship 1231251832145977Ivanchenko MV, Hanlon KS, Devine MK, Tenneson K, Emond F, Lafond JF, Kenna MA, Corey DP, Maguire CAHearing researchPreclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea. Hear Res. 2020 09 01; 394:107930.Hear Res2020-02-26T00:00:002020Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea.Authorship 1235890232199720Maguire CA, Corey DPHearing researchViral vectors for gene delivery to the inner ear. Hear Res. 2020 09 01; 394:107927.Hear Res2020-02-23T00:00:002020Viral vectors for gene delivery to the inner ear.Authorship 1254484532555200Ivanchenko MV, Cicconet M, Jandal HA, Wu X, Corey DP, Indzhykulian AAScientific dataSerial scanning electron microscopy of anti-PKHD1L1 immuno-gold labeled mouse hair cell stereocilia bundles. Sci Data. 2020 06 17; 7(1):182.Sci Data2020-06-17T00:00:002020Serial scanning electron microscopy of anti-PKHD1L1 immuno-gold labeled mouse hair cell stereocilia bundles.Authorship 14803313Authorship 1818003true1Joseph B. Martin Professor of Basic Research in the Field of NeurobiologyJoseph B. Martin Professor of Basic Research in the Field of NeurobiologyAuthorship 2254856Authorship 1501664Authorship 2153857Authorship 1328526533558532Mulhall EM, Ward A, Yang D, Koussa MA, Corey DP, Wong WPNature communicationsSingle-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection. Nat Commun. 2021 02 08; 12(1):849.Nat Commun2021-02-08T00:00:002021Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.true1Bertarelli Professor of Translational Medical ScienceBertarelli Professor of Translational Medical ScienceAuthorship 13468981033869656Ivanchenko MV, Hanlon KS, Hathaway DM, Klein AJ, Peters CW, Li Y, Tamvakologos PI, Nammour J, Maguire CA, Corey DPMolecular therapy. Methods & clinical developmentAAV-S: A versatile capsid variant for transduction of mouse and primate inner ear. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:382-398.Mol Ther Methods Clin Dev2021-03-29T00:00:002021AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear.true1Instructor in NeurobiologyInstructor in NeurobiologyAuthorship 171859234746139Ivanchenko MV, Indzhykulian AA, Corey DPFrontiers in cell and developmental biologyElectron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles. Front Cell Dev Biol. 2021; 9:744248.Front Cell Dev Biol2021-10-22T00:00:002021Electron Microscopy Techniques for Investigating Structure and Composition of Hair-Cell Stereociliary Bundles.Authorship 14108003Authorship 1410748834733312Booth KT, Hirsch Y, Vardaro AC, Ekstein J, Yefet D, Quint A, Weiden T, Corey DPFrontiers in geneticsIdentification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss. Front Genet. 2021; 12:737782.Front Genet2021-10-18T00:00:002021Identification of Novel and Recurrent Variants in MYO15A in Ashkenazi Jewish Patients With Autosomal Recessive Nonsyndromic Hearing Loss.Authorship 1461885Authorship 2177561Authorship 258370935857511Akyuz N, Karavitaki KD, Pan B, Tamvakologos PI, Brock KP, Li Y, Marks DS, Corey DPScience advancesMechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices. Sci Adv. 2022 Jul 15; 8(28):eabo1126.Sci Adv2022-07-13T00:00:002022Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices.Authorship 14594938Authorship 1594231Authorship 435071Authorship 461355437100771Ivanchenko MV, Hathaway DM, Klein AJ, Pan B, Strelkova O, De-la-Torre P, Wu X, Peters CW, Mulhall EM, Booth KT, Goldstein C, Brower J, Sotomayor M, Indzhykulian AA, Corey DPNature communicationsMini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F. Nat Commun. 2023 04 26; 14(1):2400.Nat Commun2023-04-26T00:00:002023Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F.37312453Peters CW, Hanlon KS, Ivanchenko MV, Zinn E, Linarte EF, Li Y, Levy JM, Liu DR, Kleinstiver BP, Indzhykulian AA, Corey DPMolecular therapy : the journal of the American Society of Gene TherapyRescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F. Mol Ther. 2023 08 02; 31(8):2439-2453.Mol Ther2023-06-12T00:00:002023Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F.Authorship 2652742Authorship 155311415Authorship 156113111Authorship 1587825237703299Ivanchenko MV, Corey DPProceedings of the National Academy of Sciences of the United States of AmericaFinding a window for gene therapy for hereditary deafness. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2311864120.Proc Natl Acad Sci U S A2023-09-13T00:00:002023Finding a window for gene therapy for hereditary deafness.true1Walter Augustus Lecompte Professor of Otology and Laryngology, EmeritusWalter Augustus Lecompte Professor of Otology and Laryngology, Emeritustrue1Harold F. Schuknecht Professor of Otology and LaryngologyHarold F. Schuknecht Professor of Otology and Laryngologytrue1Associate Professor of Otolaryngology Head and Neck SurgeryAssociate Professor of Otolaryngology Head and Neck Surgerytrue1Eaton-Peabody Professor of Otolaryngology Head and Neck SurgeryEaton-Peabody Professor of Otolaryngology Head and Neck Surgerytrue1Assistant Professor of Otolaryngology Head and Neck SurgeryAssistant Professor of Otolaryngology Head and Neck SurgeryAuthorship 1862522Authorship 16112701138014037Ivanchenko MV, Hathaway DM, Mulhall EM, Booth KT, Wang M, Peters CW, Klein AJ, Chen X, Li Y, György B, Corey DPbioRxiv : the preprint server for biologyPCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F. bioRxiv. 2023 Nov 13.bioRxiv2023-11-13T00:00:002023PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F.Authorship 5097054true1Lecturer on NeurobiologyLecturer on Neurobiologytrue1Professor of Otolaryngology Head and Neck SurgeryProfessor of Otolaryngology Head and Neck SurgeryAuthorship 1700812Authorship 3111115Authorship 4944244Authorship 6340212Authorship 35613376316158Aldrich RW, Corey DP, Stevens CFNatureA reinterpretation of mammalian sodium channel gating based on single channel recording. Nature. 1983 Dec 1-7; 306(5942):436-41.Nature1983-12-01T00:00:001983A reinterpretation of mammalian sodium channel gating based on single channel recording.Authorship 898812Authorship 3767389Authorship 650317Authorship 747541Authorship 5660841Authorship 2486692Authorship 3353694Authorship 3403122Authorship 2124398Authorship 401692Authorship 3118022Authorship 27950911Authorship 7528112Authorship 777813Authorship 287462Authorship 2619332Authorship 708104210704190Keats BJ, Corey DPAmerican journal of medical geneticsThe usher syndromes. Am J Med Genet. 1999 Sep 24; 89(3):158-66.Am J Med Genet1999-09-24T00:00:001999The usher syndromes.Authorship 3295353Authorship 2949971Authorship 2256943Authorship 2982142Authorship 2370512Authorship 205792Authorship 3487713Authorship 4106851Authorship 32036111Authorship 3220082Authorship 454532Authorship 4772668Authorship 348262Authorship 51672210Authorship 762692324794279Sotomayor M, Gaudet R, Corey DPTrends in cell biologySorting out a promiscuous superfamily: towards cadherin connectomics. Trends Cell Biol. 2014 Sep; 24(9):524-36.Trends Cell Biol2014-04-30T00:00:002014Sorting out a promiscuous superfamily: towards cadherin connectomics.Authorship 4574099Authorship 4594121Authorship 4232794Authorship 2303216Authorship 4843189Authorship 5129652Authorship 521943325772365Scheffer DI, Zhang DS, Shen J, Indzhykulian A, Karavitaki KD, Xu YJ, Wang Q, Lin JJ, Chen ZY, Corey DPCell reportsXIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia. Cell Rep. 2015 Mar 24; 10(11):1811-8.Cell Rep2015-03-12T00:00:002015XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia.Authorship 2061911Authorship 5450051Authorship 498075225904789Scheffer DI, Shen J, Corey DP, Chen ZYThe Journal of neuroscience : the official journal of the Society for NeuroscienceGene Expression by Mouse Inner Ear Hair Cells during Development. J Neurosci. 2015 Apr 22; 35(16):6366-80.J Neurosci2015-04-22T00:00:002015Gene Expression by Mouse Inner Ear Hair Cells during Development.Authorship 5768462Authorship 9521312Authorship 7833933Authorship 7833946Authorship 7833955Authorship 78339610Authorship 783397325898120Drummond MC, Barzik M, Bird JE, Zhang DS, Lechene CP, Corey DP, Cunningham LL, Friedman TBNature communicationsLive-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear. Nat Commun. 2015 Apr 21; 6:6873.Nat Commun2015-04-21T00:00:002015Live-cell imaging of actin dynamics reveals mechanisms of stereocilia length regulation in the inner ear.25497456Kwan KY, Shen J, Corey DPStem cell reportsC-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells. Stem Cell Reports. 2015 Jan 13; 4(1):47-60.Stem Cell Reports2014-12-11T00:00:002014C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells.25897778Narayanan P, Chatterton P, Ikeda A, Ikeda S, Corey DP, Ervasti JM, Perrin BJNature communicationsLength regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins. Nat Commun. 2015 Apr 21; 6:6855.Nat Commun2015-04-21T00:00:002015Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins.Authorship 2805765Authorship 31599912Authorship 1211143Authorship 3286885Authorship 36979214Authorship 5463353Authorship 2551024Authorship 3044592Authorship 4288434Authorship 2712667Authorship 228301Authorship 3129043Authorship 2242313Authorship 3987261Authorship 512151Authorship 4712553Authorship 3890684Authorship 4157104Authorship 3146632Authorship 819211426209310Shen J, Scheffer DI, Kwan KY, Corey DPDatabase : the journal of biological databases and curationSHIELD: an integrative gene expression database for inner ear research. Database (Oxford). 2015; 2015:bav071.Database (Oxford)2015-07-24T00:00:002015SHIELD: an integrative gene expression database for inner ear research.Authorship 4713671Authorship 4856753Authorship 83365917Authorship 833972226188009Vuckovic D, Dawson S, Scheffer DI, Rantanen T, Morgan A, Di Stazio M, Vozzi D, Nutile T, Concas MP, Biino G, Nolan L, Bahl A, Loukola A, Viljanen A, Davis A, Ciullo M, Corey DP, Pirastu M, Gasparini P, Girotto GHuman molecular geneticsGenome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss. Hum Mol Genet. 2015 Oct 01; 24(19):5655-64.Hum Mol Genet2015-07-17T00:00:002015Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.26352665Indzhykulian AA, Corey DPCell reportsIn the Right Place at the Right Time: Is TMC1/2 the Transduction Channel for Hearing? Cell Rep. 2015 Sep 08; 12(10):1531-2.Cell Rep2015-09-08T00:00:002015In the Right Place at the Right Time: Is TMC1/2 the Transduction Channel for Hearing?Authorship 4906451Authorship 8528001026689366Girotto G, Scheffer DI, Morgan A, Vozzi D, Rubinato E, Di Stazio M, Muzzi E, Pensiero S, Giersch AB, Corey DP, Gasparini PScientific reportsPSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss. Sci Rep. 2015 Dec 22; 5:18568.Sci Rep2015-12-22T00:00:002015PSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss.Authorship 4792215Authorship 8633176Authorship 870415426943906Zhao H, Shen A, Xiang YK, Corey DPPloS oneThree Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity. PLoS One. 2016; 11(3):e0150125.PLoS One2016-03-04T00:00:002016Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.26593130Lin SY, Vollrath MA, Mangosing S, Shen J, Cardenas E, Corey DPThe Journal of physiologyThe zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors. J Physiol. 2016 Feb 15; 594(4):895-914.J Physiol2015-12-28T00:00:002015The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.Authorship 874034627007841Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DENaturePrimary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60.Nature2016-03-23T00:00:002016Primary cilia are not calcium-responsive mechanosensors.Authorship 3918344Authorship 4876342MVI3MarynaIvanchenkoMaryna V Ivanchenko, M.D., Ph.D.147747Ivanchenko, MarynaInstructor in NeurobiologyAuthorship 882564927196058Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DPPloS oneHair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One. 2016; 11(5):e0155577.PLoS One2016-05-19T00:00:002016Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.2010-07-30T00:00:002010-06-01T00:00:00STORM Imaging of Frog Saccular Hair CellsSummerAuthorship 7594512Assistant Professor1Associate Professor0Full Professor4Instructor3Lecturer5Other Faculty220 Longwood AveHarvard Medical SchoolNeurobiology, Goldenson 443220 Longwood AveBoston02115MAAuthorship 745692Authorship 95163Authorship 4921798Authorship 5260892Authorship 54754122020-06-30COREY, DAVID P1994-07-01Molecular Basis of Inherited DeafnessR01DC0022812021-01-31COREY, DAVID P1984-09-01Molecular Mechanisms of Auditory TransductionR01DC0003041988-02-28COREY, DAVID P1984-09-01MOLECULAR MECHANISM OF AUDITORY TRANSDUCTIONR01NS0220592021-08-31SABATINI, BERNARDO L2011-09-30HMS/BCH Center for Neuroscience ResearchP30NS0720301992-06-30COREY, DAVID P1991-07-01SENSORY TRANSDUCTION--A SYMPOSIUMR13DC0012292013-07-31LEVINE, MICHAEL J1990-09-01High Performance Computing for Biomedical ResearchP41RR006009Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorAuthorship 915212627622466Asadnia M, Kottapalli AG, Karavitaki KD, Warkiani ME, Miao J, Corey DP, Triantafyllou MScientific reportsFrom Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance. Sci Rep. 2016 09 13; 6:32955.Sci Rep2016-09-13T00:00:002016From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance.Authorship 4401993Authorship 5471061Authorship 9309921Authorship 935509327798174Corey DP, Holt JRThe Journal of neuroscience : the official journal of the Society for NeuroscienceAre TMCs the Mechanotransduction Channels of Vertebrate Hair Cells? J Neurosci. 2016 10 26; 36(43):10921-10926.J Neurosci2016-10-26T00:00:002016Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?27824920Christensen AP, Akyuz N, Corey DPPloS oneThe Outer Pore and Selectivity Filter of TRPA1. PLoS One. 2016; 11(11):e0166167.PLoS One2016-11-08T00:00:002016The Outer Pore and Selectivity Filter of TRPA1.Authorship 27553715Authorship 94325720Authorship 9422991028000760Rivera-Monroy J, Musiol L, Unthan-Fechner K, Farkas Á, Clancy A, Coy-Vergara J, Weill U, Gockel S, Lin SY, Corey DP, Kohl T, Ströbel P, Schuldiner M, Schwappach B, Vilardi FScientific reportsMice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo. Sci Rep. 2016 12 21; 6:39464.Sci Rep2016-12-21T00:00:002016Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.27458190Vogl C, Panou I, Yamanbaeva G, Wichmann C, Mangosing SJ, Vilardi F, Indzhykulian AA, Pangršic T, Santarelli R, Rodriguez-Ballesteros M, Weber T, Jung S, Cardenas E, Wu X, Wojcik SM, Kwan KY, Del Castillo I, Schwappach B, Strenzke N, Corey DP, Lin SY, Moser TThe EMBO journalTryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J. 2016 12 01; 35(23):2536-2552.EMBO J2016-07-25T00:00:002016Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.Authorship 4769268Authorship 9495181528082074György B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP, Maguire CAMolecular therapy : the journal of the American Society of Gene TherapyRescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Mol Ther. 2017 02 01; 25(2):379-391.Mol Ther2017-01-09T00:00:002017Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.Authorship 956663428160907Tannous BA, Chiocca EA, Jacobs AH, Corey DP, Breakefield XOMolecular therapy : the journal of the American Society of Gene TherapyTannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312.Mol Ther2016-12-06T00:00:002016Tannous et al. Respond.8764651Liman ER, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceElectrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ. J Neurosci. 1996 Aug 01; 16(15):4625-37.J Neurosci1996-08-01T00:00:001996Electrophysiological characterization of chemosensory neurons from the mouse vomeronasal organ.9013777Grosson CL, Cannon SC, Corey DP, Gusella JFBrain research. Molecular brain researchSequence of the voltage-gated sodium channel beta1-subunit in wild-type and in quivering mice. Brain Res Mol Brain Res. 1996 Dec; 42(2):222-6.Brain Res Mol Brain Res1996-12-01T00:00:001996Sequence of the voltage-gated sodium channel beta1-subunit in wild-type and in quivering mice.15653467Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS, García-Añoveros J, Hinds PW, Corwin JT, Corey DP, Chen ZYScience (New York, N.Y.)Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science. 2005 Feb 18; 307(5712):1114-8.Science2005-01-13T00:00:002005Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein.10200223Holt JR, Johns DC, Wang S, Chen ZY, Dunn RJ, Marban E, Corey DPJournal of neurophysiologyFunctional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J Neurophysiol. 1999 Apr; 81(4):1881-8.J Neurophysiol1999-04-01T00:00:001999Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors.10318963Liman ER, Corey DP, Dulac CProceedings of the National Academy of Sciences of the United States of AmericaTRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5791-6.Proc Natl Acad Sci U S A1999-05-11T00:00:001999TRP2: a candidate transduction channel for mammalian pheromone sensory signaling.11086976Corey DPNeuronSound amplification in the inner ear: it takes TM to tango. Neuron. 2000 Oct; 28(1):7-9.Neuron2000-10-01T00:00:002000Sound amplification in the inner ear: it takes TM to tango.8900236Weston MD, Kelley PM, Overbeck LD, Wagenaar M, Orten DJ, Hasson T, Chen ZY, Corey D, Mooseker M, Sumegi J, Cremers C, Moller C, Jacobson SG, Gorin MB, Kimberling WJAmerican journal of human geneticsMyosin VIIA mutation screening in 189 Usher syndrome type 1 patients. Am J Hum Genet. 1996 Nov; 59(5):1074-83.Am J Hum Genet1996-11-01T00:00:001996Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients.1369769Corey DP, Assad JASociety of General Physiologists seriesTransduction and adaptation in vertebrate hair cells: correlating structure with function. Soc Gen Physiol Ser. 1992; 47:325-42.Soc Gen Physiol Ser1992-01-01T00:00:001992Transduction and adaptation in vertebrate hair cells: correlating structure with function.1381121Pickles JO, Corey DPTrends in neurosciencesMechanoelectrical transduction by hair cells. Trends Neurosci. 1992 Jul; 15(7):254-9.Trends Neurosci1992-07-01T00:00:001992Mechanoelectrical transduction by hair cells.9246460Gillespie PG, Hasson T, Garcia JA, Corey DPCold Spring Harbor symposia on quantitative biologyMultiple myosin isozymes and hair-cell function. Cold Spring Harb Symp Quant Biol. 1996; 61:309-18.Cold Spring Harb Symp Quant Biol1996-01-01T00:00:001996Multiple myosin isozymes and hair-cell function.9288096Ozelius LJ, Hewett JW, Page CE, Bressman SB, Kramer PL, Shalish C, de Leon D, Brin MF, Raymond D, Corey DP, Fahn S, Risch NJ, Buckler AJ, Gusella JF, Breakefield XONature geneticsThe early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat Genet. 1997 Sep; 17(1):40-8.Nat Genet1997-09-01T00:00:001997The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein.11523564Leung JC, Klein C, Friedman J, Vieregge P, Jacobs H, Doheny D, Kamm C, DeLeon D, Pramstaller PP, Penney JB, Eisengart M, Jankovic J, Gasser T, Bressman SB, Corey DP, Kramer P, Brin MF, Ozelius LJ, Breakefield XONeurogeneticsNovel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism. Neurogenetics. 2001 Jul; 3(3):133-43.Neurogenetics2001-07-01T00:00:002001Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism.8884266Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NAGenomicsMapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15; 36(3):431-9.Genomics1996-09-15T00:00:001996Mapping of unconventional myosins in mouse and human.12925273Corey DPNeuronNew TRP channels in hearing and mechanosensation. Neuron. 2003 Aug 14; 39(4):585-8.Neuron2003-08-14T00:00:002003New TRP channels in hearing and mechanosensation.11724811Gillespie PG, Albanesi JP, Bahler M, Bement WM, Berg JS, Burgess DR, Burnside B, Cheney RE, Corey DP, Coudrier E, de Lanerolle P, Hammer JA, Hasson T, Holt JR, Hudspeth AJ, Ikebe M, Kendrick-Jones J, Korn ED, Li R, Mercer JA, Milligan RA, Mooseker MS, Ostap EM, Petit C, Pollard TD, Sellers JR, Soldati T, Titus MAThe Journal of cell biologyMyosin-I nomenclature. J Cell Biol. 2001 Nov 26; 155(5):703-4.J Cell Biol2001-11-26T00:00:002001Myosin-I nomenclature.11739374Duggan A, Garcia-Anoveros J, Corey DPThe Journal of biological chemistryThe PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem. 2002 Feb 15; 277(7):5203-8.J Biol Chem2001-12-05T00:00:002001The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.1527581Assad JA, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceAn active motor model for adaptation by vertebrate hair cells. J Neurosci. 1992 Sep; 12(9):3291-309.J Neurosci1992-09-01T00:00:001992An active motor model for adaptation by vertebrate hair cells.20696370Wilson RI, Corey DPNeuronThe force be with you: a mechanoreceptor channel in proprioception and touch. Neuron. 2010 Aug 12; 67(3):349-51.Neuron2010-08-12T00:00:002010The force be with you: a mechanoreceptor channel in proprioception and touch.12162364Chen ZY, Corey DPJournal of the Association for Research in Otolaryngology : JAROAn inner ear gene expression database. J Assoc Res Otolaryngol. 2002 Jun; 3(2):140-8.J Assoc Res Otolaryngol2002-06-01T00:00:002002An inner ear gene expression database.8845155Denk W, Holt JR, Shepherd GM, Corey DPNeuronCalcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links. Neuron. 1995 Dec; 15(6):1311-21.Neuron1995-12-01T00:00:001995Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links.9037075García-Añoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DPProceedings of the National Academy of Sciences of the United States of AmericaBNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1459-64.Proc Natl Acad Sci U S A1997-02-18T00:00:001997BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.12382281Chen ZY, Corey DPJournal of neurobiologyUnderstanding inner ear development with gene expression profiling. J Neurobiol. 2002 Nov 05; 53(2):276-85.J Neurobiol2002-11-05T00:00:002002Understanding inner ear development with gene expression profiling.12456710Corey DJournal of cell scienceSensory transduction in the ear. J Cell Sci. 2003 Jan 01; 116(Pt 1):1-3.J Cell Sci2003-01-01T00:00:002003Sensory transduction in the ear.1698397Barres BA, Koroshetz WJ, Chun LL, Corey DPNeuronIon channel expression by white matter glia: the type-1 astrocyte. Neuron. 1990 Oct; 5(4):527-44.Neuron1990-10-01T00:00:001990Ion channel expression by white matter glia: the type-1 astrocyte.1849724Cannon SC, Brown RH, Corey DPNeuronA sodium channel defect in hyperkalemic periodic paralysis: potassium-induced failure of inactivation. Neuron. 1991 Apr; 6(4):619-26.Neuron1991-04-01T00:00:001991A sodium channel defect in hyperkalemic periodic paralysis: potassium-induced failure of inactivation.15118709Corey DP, Sotomayor MNatureHearing: tightrope act. Nature. 2004 Apr 29; 428(6986):901-3.Nature2004-04-29T00:00:002004Hearing: tightrope act.12719379Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F, Du LL, Welch KO, Petit C, Smith RJ, Webb BT, Yan D, Arnos KS, Corey D, Dallos P, Nance WE, Chen ZYHuman molecular geneticsPrestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet. 2003 May 15; 12(10):1155-62.Hum Mol Genet2003-05-15T00:00:002003Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss.15837205Sotomayor M, Corey DP, Schulten KStructure (London, England : 1993)In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure. 2005 Apr; 13(4):669-82.Structure2005-04-01T00:00:002005In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats.9070921Kelley PM, Weston MD, Chen ZY, Orten DJ, Hasson T, Overbeck LD, Pinnt J, Talmadge CB, Ing P, Mooseker MS, Corey D, Sumegi J, Kimberling WJGenomicsThe genomic structure of the gene defective in Usher syndrome type Ib (MYO7A). Genomics. 1997 Feb 15; 40(1):73-9.Genomics1997-02-15T00:00:001997The genomic structure of the gene defective in Usher syndrome type Ib (MYO7A).16630838Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DPNeuronTRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006 Apr 20; 50(2):277-89.Neuron2006-04-20T00:00:002006TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.2158266Barres BA, Chun LL, Corey DPAnnual review of neuroscienceIon channels in vertebrate glia. Annu Rev Neurosci. 1990; 13:441-74.Annu Rev Neurosci1990-01-01T00:00:001990Ion channels in vertebrate glia.11306621García-Añoveros J, Samad TA, Zuvela-Jelaska L, Woolf CJ, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceTransport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci. 2001 Apr 15; 21(8):2678-86.J Neurosci2001-04-15T00:00:002001Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons.19632231Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O'Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LAGastroenterologyThe ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology. 2009 Dec; 137(6):2084-2095.e3.Gastroenterology2009-07-24T00:00:002009The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.6601694Corey DP, Hudspeth AJThe Journal of neuroscience : the official journal of the Society for NeuroscienceKinetics of the receptor current in bullfrog saccular hair cells. J Neurosci. 1983 May; 3(5):962-76.J Neurosci1983-05-01T00:00:001983Kinetics of the receptor current in bullfrog saccular hair cells.15483558Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DSNatureTRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 2004 Dec 09; 432(7018):723-30.Nature2004-10-13T00:00:002004TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.7931574Shepherd GM, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceThe extent of adaptation in bullfrog saccular hair cells. J Neurosci. 1994 Oct; 14(10):6217-29.J Neurosci1994-10-01T00:00:001994The extent of adaptation in bullfrog saccular hair cells.8038396Corey DP, Howard JBiophysical journalModels for ion channel gating with compliant states. Biophys J. 1994 Apr; 66(4):1254-7.Biophys J1994-04-01T00:00:001994Models for ion channel gating with compliant states.9348343Holt JR, Corey DP, Eatock RAThe Journal of neuroscience : the official journal of the Society for NeuroscienceMechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. J Neurosci. 1997 Nov 15; 17(22):8739-48.J Neurosci1997-11-15T00:00:001997Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ.329282Hudspeth AJ, Corey DPProceedings of the National Academy of Sciences of the United States of AmericaSensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2407-11.Proc Natl Acad Sci U S A1977-06-01T00:00:001977Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli.2571687Barres BA, Chun LL, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceCalcium current in cortical astrocytes: induction by cAMP and neurotransmitters and permissive effect of serum factors. J Neurosci. 1989 Sep; 9(9):3169-75.J Neurosci1989-09-01T00:00:001989Calcium current in cortical astrocytes: induction by cAMP and neurotransmitters and permissive effect of serum factors.16537570Kock N, Naismith TV, Boston HE, Ozelius LJ, Corey DP, Breakefield XO, Hanson PIHuman molecular geneticsEffects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier. Hum Mol Genet. 2006 Apr 15; 15(8):1355-64.Hum Mol Genet2006-03-14T00:00:002006Effects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier.10452370Derby ML, Sena-Esteves M, Breakefield XO, Corey DPHearing researchGene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors. Hear Res. 1999 Aug; 134(1-2):1-8.Hear Res1999-08-01T00:00:001999Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.Authorship 1010975928899994Avenarius MR, Krey JF, Dumont RA, Morgan CP, Benson CB, Vijayakumar S, Cunningham CL, Scheffer DI, Corey DP, Müller U, Jones SM, Barr-Gillespie PGThe Journal of cell biologyHeterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol. 2017 11 06; 216(11):3861-3881.J Cell Biol2017-09-12T00:00:002017Heterodimeric capping protein is required for stereocilia length and width regulation.2466789Barres BA, Chun LL, Corey DPGliaIon channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes. Glia. 1988; 1(1):10-30.Glia1988-01-01T00:00:001988Ion channel expression by white matter glia: I. Type 2 astrocytes and oligodendrocytes.10984435Berg JS, Derfler BH, Pennisi CM, Corey DP, Cheney REJournal of cell scienceMyosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin. J Cell Sci. 2000 Oct; 113 Pt 19:3439-51.J Cell Sci2000-10-01T00:00:002000Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin.1764247Assad JA, Shepherd GM, Corey DPNeuronTip-link integrity and mechanical transduction in vertebrate hair cells. Neuron. 1991 Dec; 7(6):985-94.Neuron1991-12-01T00:00:001991Tip-link integrity and mechanical transduction in vertebrate hair cells.14659085Cheung EL, Corey DPNeuronA gradient of single-channel conductance in the cochlea: tuning the cochlea's strings? Neuron. 2003 Dec 04; 40(5):875-6.Neuron2003-12-04T00:00:002003A gradient of single-channel conductance in the cochlea: tuning the cochlea's strings?2555460Hacohen N, Assad JA, Smith WJ, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceRegulation of tension on hair-cell transduction channels: displacement and calcium dependence. J Neurosci. 1989 Nov; 9(11):3988-97.J Neurosci1989-11-01T00:00:001989Regulation of tension on hair-cell transduction channels: displacement and calcium dependence.2908449Barres BA, Silverstein BE, Corey DP, Chun LLNeuronImmunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron. 1988 Nov; 1(9):791-803.Neuron1988-11-01T00:00:001988Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning.8884267Chen ZY, Hasson T, Kelley PM, Schwender BJ, Schwartz MF, Ramakrishnan M, Kimberling WJ, Mooseker MS, Corey DPGenomicsMolecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B. Genomics. 1996 Sep 15; 36(3):440-8.Genomics1996-09-15T00:00:001996Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B.7558018Chen H, Thalmann I, Adams JC, Avraham KB, Copeland NG, Jenkins NA, Beier DR, Corey DP, Thalmann R, Duyk GMGenomicscDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. Genomics. 1995 Jun 10; 27(3):389-98.Genomics1995-06-10T00:00:001995cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs.11853671Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PGCellA chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 2002 Feb 08; 108(3):371-81.Cell2002-02-08T00:00:002002A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.20399731Sotomayor M, Weihofen WA, Gaudet R, Corey DPNeuronStructural determinants of cadherin-23 function in hearing and deafness. Neuron. 2010 Apr 15; 66(1):85-100.Neuron2010-04-15T00:00:002010Structural determinants of cadherin-23 function in hearing and deafness.45121Corey DP, Hudspeth AJNatureIonic basis of the receptor potential in a vertebrate hair cell. Nature. 1979 Oct 25; 281(5733):675-7.Nature1979-10-25T00:00:001979Ionic basis of the receptor potential in a vertebrate hair cell.22246323Zhang DS, Piazza V, Perrin BJ, Rzadzinska AK, Poczatek JC, Wang M, Prosser HM, Ervasti JM, Corey DP, Lechene CPNatureMulti-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia. Nature. 2012 Jan 15; 481(7382):520-4.Nature2012-01-15T00:00:002012Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.17893717Corey DPNature neuroscienceStringing the fiddle: the inner ear's two-part invention. Nat Neurosci. 2007 Oct; 10(10):1232-3.Nat Neurosci2007-10-01T00:00:002007Stringing the fiddle: the inner ear's two-part invention.3498016Eatock RA, Corey DP, Hudspeth AJThe Journal of neuroscience : the official journal of the Society for NeuroscienceAdaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus. J Neurosci. 1987 Sep; 7(9):2821-36.J Neurosci1987-09-01T00:00:001987Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus.8290543Corey DP, Breakefield XOProceedings of the National Academy of Sciences of the United States of AmericaTranscription factors in inner ear development. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):433-6.Proc Natl Acad Sci U S A1994-01-18T00:00:001994Transcription factors in inner ear development.19237590Kwan KY, Corey DPThe Journal of general physiologyBurning cold: involvement of TRPA1 in noxious cold sensation. J Gen Physiol. 2009 Mar; 133(3):251-6.J Gen Physiol2009-03-01T00:00:002009Burning cold: involvement of TRPA1 in noxious cold sensation.2468161Assad JA, Hacohen N, Corey DPProceedings of the National Academy of Sciences of the United States of AmericaVoltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2918-22.Proc Natl Acad Sci U S A1989-04-01T00:00:001989Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells.6601693Corey DP, Hudspeth AJThe Journal of neuroscience : the official journal of the Society for NeuroscienceAnalysis of the microphonic potential of the bullfrog's sacculus. J Neurosci. 1983 May; 3(5):942-61.J Neurosci1983-05-01T00:00:001983Analysis of the microphonic potential of the bullfrog's sacculus.318064Corey DP, Hudspeth AJBiophysical journalResponse latency of vertebrate hair cells. Biophys J. 1979 Jun; 26(3):499-506.Biophys J1979-06-01T00:00:001979Response latency of vertebrate hair cells.20610739Karavitaki KD, Corey DPThe Journal of neuroscience : the official journal of the Society for NeuroscienceSliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels. J Neurosci. 2010 Jul 07; 30(27):9051-63.J Neurosci2010-07-07T00:00:002010Sliding adhesion confers coherent motion to hair cell stereocilia and parallel gating to transduction channels.20948626Corey DPF1000 biology reportsCell biology of mechanotransduction in inner-ear hair cells. F1000 Biol Rep. 2009 Jul 27; 1:58.F1000 Biol Rep2009-07-27T00:00:002009Cell biology of mechanotransduction in inner-ear hair cells.9655510García-Añoveros J, García JA, Liu JD, Corey DPNeuronThe nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations. Neuron. 1998 Jun; 20(6):1231-41.Neuron1998-06-01T00:00:001998The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.9056725Garcia-Anoveros J, Corey DPAnnual review of neuroscienceThe molecules of mechanosensation. Annu Rev Neurosci. 1997; 20:567-94.Annu Rev Neurosci1997-01-01T00:00:001997The molecules of mechanosensation.6090654Corey DP, Dubinsky JM, Schwartz EAThe Journal of physiologyThe calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina. J Physiol. 1984 Sep; 354:557-75.J Physiol1984-09-01T00:00:001984The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina.11050202Holt JR, Corey DPProceedings of the National Academy of Sciences of the United States of AmericaTwo mechanisms for transducer adaptation in vertebrate hair cells. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11730-5.Proc Natl Acad Sci U S A2000-10-24T00:00:002000Two mechanisms for transducer adaptation in vertebrate hair cells.11401444Chen ZY, Hasson T, Zhang DS, Schwender BJ, Derfler BH, Mooseker MS, Corey DPGenomicsMyosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia. Genomics. 2001 Mar 15; 72(3):285-96.Genomics2001-03-15T00:00:002001Myosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia.9182663Hasson T, Gillespie PG, Garcia JA, MacDonald RB, Zhao Y, Yee AG, Mooseker MS, Corey DPThe Journal of cell biologyUnconventional myosins in inner-ear sensory epithelia. J Cell Biol. 1997 Jun 16; 137(6):1287-307.J Cell Biol1997-06-16T00:00:001997Unconventional myosins in inner-ear sensory epithelia.1346972Shepherd GM, Corey DPThe New biologistSensational science. Sensory Transduction: 45th Annual Symposium of the Society of General Physiologists, Marine Biological Laboratory, Woods Hole, MA, USA, September 5-8, 1991. New Biol. 1992 Jan; 4(1):48-52.New Biol1992-01-01T00:00:001992Sensational science. Sensory Transduction: 45th Annual Symposium of the Society of General Physiologists, Marine Biological Laboratory, Woods Hole, MA, USA, September 5-8, 1991.