Professor of Anaesthesia (Pharmacology), Emeritus
Kohane DS, Lu NT, Gökgöl-Kline AC, Shubina M, Kuang Y, Hall S, Strichartz GR, Berde CB
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9.
The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo.
Guo XT, Castle NA, Chernoff DM, Strichartz GR
Annals of the New York Academy of Sciences
Comparative inhibition of voltage-gated cation channels by local anesthetics. Ann N Y Acad Sci. 1991; 625:181-99.
Comparative inhibition of voltage-gated cation channels by local anesthetics.
Benzon HT, Gissen AJ, Strichartz GR, Avram MJ, Covino BG
The effect of polyethylene glycol on mammalian nerve impulses. Anesth Analg. 1987 Jun; 66(6):553-9.
The effect of polyethylene glycol on mammalian nerve impulses.
Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons. Reg Anesth Pain Med. 2018 Aug; 43(6):605-612.
Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons.
Benzon HT, Strichartz GR, Gissen AJ, Shanks CA, Covino BG, Datta S
Developmental neurophysiology of mammalian peripheral nerves and age-related differential sensitivity to local anaesthetic. Br J Anaesth. 1988 Dec; 61(6):754-60.
Developmental neurophysiology of mammalian peripheral nerves and age-related differential sensitivity to local anaesthetic.
The pH-dependent local anesthetic activity of diethylaminoethanol, a procaine metabolite. Anesthesiology. 1988 Apr; 68(4):501-6.
The pH-dependent local anesthetic activity of diethylaminoethanol, a procaine metabolite.
Toxicon : official journal of the International Society on Toxinology
Effects of venom from Conus striatus on the delayed rectifier potassium current of molluscan neurons. Toxicon. 1987; 25(3):267-78.
Effects of venom from Conus striatus on the delayed rectifier potassium current of molluscan neurons.
Pharmacological properties of sodium channels in nerve membranes. Adv Neurol. 1981; 31:343-56.
Pharmacological properties of sodium channels in nerve membranes.
Structure of the saxitoxin binding site at sodium channels in nerve membranes. Exchange of tritium from bound toxin molecules. Mol Pharmacol. 1982 Mar; 21(2):343-50.
Structure of the saxitoxin binding site at sodium channels in nerve membranes. Exchange of tritium from bound toxin molecules.
Proceedings: Binding to nerve and muscle of saxitoxin labelled by a new method of tritium exchange. J Physiol. 1976 Jun; 258(2):99P-100P.
Proceedings: Binding to nerve and muscle of saxitoxin labelled by a new method of tritium exchange.
Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology. 1994 May; 80(5):1082-93.
Irreversible conduction block in isolated nerve by high concentrations of local anesthetics.
Raymond SA, Abrams SB, Raemer DB, Philip JH, Strichartz GR
The NerveSeeker: a system for automated nerve localization. Reg Anesth. 1992 May-Jun; 17(3):151-62.
The NerveSeeker: a system for automated nerve localization.
Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve. Anesthesiology. 2001 Dec; 95(6):1441-54.
Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve.
The long and short of differential block. Anesthesiology. 1989 May; 70(5):725-8.
The long and short of differential block.
Khodorova A, Montmayeur JP, Strichartz G
Endothelin receptors and pain. J Pain. 2009 Jan; 10(1):4-28.
Ohri R, Blaskovich P, Wang JC, Pham L, Nichols G, Hildebrand W, Costa D, Scarborough N, Herman C, Strichartz G
Prolonged nerve block by microencapsulated bupivacaine prevents acute postoperative pain in rats. Reg Anesth Pain Med. 2012 Nov-Dec; 37(6):607-15.
Prolonged nerve block by microencapsulated bupivacaine prevents acute postoperative pain in rats.
Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve. J Gen Physiol. 1984 Aug; 84(2):281-305.
Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve.
The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve. J Physiol. 1975 Aug; 250(1):34P-35P.
The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve.
Beyond neurons: the complex sources of pain transduction. Pain. 2010 Feb; 148(2):180-181.
Beyond neurons: the complex sources of pain transduction.
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J. 1990 Jul; 58(1):69-81.
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence.
Ende HB, Soens MA, Nandi M, Strichartz GR, Schreiber KL
Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain. Anesth Analg. 2019 10; 129(4):e118-e121.
Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain.
Khodorova A, Zhang Y, Nicol G, Strichartz G
Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain. Physiol Res. 2018 06 27; 67(Suppl 1):S215-S225.
Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain.
Wang ZY, Tung SR, Strichartz GR, Håkanson R
Investigation of the specificity of FK 888 as a tachykinin NK1 receptor antagonist. Br J Pharmacol. 1994 Apr; 111(4):1342-6.
Investigation of the specificity of FK 888 as a tachykinin NK1 receptor antagonist.
A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. J Physiol. 1976 Oct; 261(2):477-94.
A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve. Anesthesiology. 1994 Sep; 81(3):657-67.
Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve.
Further comments on the failure of impulse propagation in nerves marginally blocked by local anesthetic. Anesth Analg. 1990 Jan; 70(1):121-2.
Further comments on the failure of impulse propagation in nerves marginally blocked by local anesthetic.
Strichartz G, Rando T, Hall S, Gitschier J, Hall L, Magnani B, Bay CH
On the mechanism by which saxitoxin binds to and blocks sodium channels. Ann N Y Acad Sci. 1986; 479:96-112.
On the mechanism by which saxitoxin binds to and blocks sodium channels.
Jackson FR, Gitschier J, Strichartz GR, Hall LM
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus. J Neurosci. 1985 May; 5(5):1144-51.
Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus.
Zhang J, Hadlock T, Gent A, Strichartz GR
Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization. Biophys J. 2007 Jun 01; 92(11):3988-4001.
Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization.
The Journal of pharmacology and experimental therapeutics
Structure-activity relationship of lidocaine homologs producing tonic and frequency-dependent impulse blockade in nerve. J Pharmacol Exp Ther. 1986 Jun; 237(3):773-81.
Structure-activity relationship of lidocaine homologs producing tonic and frequency-dependent impulse blockade in nerve.
An integrated view of the molecular toxinology of sodium channel gating in excitable cells. Annu Rev Neurosci. 1987; 10:237-67.
An integrated view of the molecular toxinology of sodium channel gating in excitable cells.
Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture. J Gen Physiol. 1983 Sep; 82(3):365-84.
Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture.
Neurotoxicity of 5% lignocaine. Br J Anaesth. 1995 Sep; 75(3):376.
The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesth Analg. 1993 Feb; 76(2):295-301.
The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers.
Nociceptive sensitization by endothelin-1. Brain Res Rev. 2009 Apr; 60(1):36-42.
Nociceptive sensitization by endothelin-1.
Vmax as a measure of GNa in nerve and cardiac membranes. Biophys J. 1978 Jul; 23(1):153-6.
Vmax as a measure of GNa in nerve and cardiac membranes.
Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission. Br J Pharmacol. 1994 Jan; 111(1):179-84.
Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission.
Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides. Toxicon. 1988; 26(10):941-51.
Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides.
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels. Mol Pharmacol. 1986 May; 29(5):467-77.
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels.
Moczydlowski E, Olivera BM, Gray WR, Strichartz GR
Proceedings of the National Academy of Sciences of the United States of America
Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5321-5.
Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.
Krueger BK, Ratzlaff RW, Strichartz GR, Blaustein MP
Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain. J Membr Biol. 1979 Nov 30; 50(3-4):287-310.
Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain.
On the voltage-dependent action of tetrodotoxin. Biophys J. 1977 Mar; 17(3):275-9.
On the voltage-dependent action of tetrodotoxin.
Strichartz GR, Hall S, Magnani B, Hong CY, Kishi Y, Debin JA
The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin. Toxicon. 1995 Jun; 33(6):723-37.
The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin.
Wilder RT, Berde CB, Griggs CT, Chickalingaiah R, Strichartz G
Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells. Reg Anesth. 1993 Sep-Oct; 18(5):283-9.
Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells.
Thalhammer JG, Raymond SA, Popitz-Bergez FA, Strichartz GR
Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosens Mot Res. 1994; 11(3):243-57.
Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat.
Protracted relief of experimental neuropathic pain by systemic local anesthetics. How, where, and when. Anesthesiology. 1995 Oct; 83(4):654-5.
Protracted relief of experimental neuropathic pain by systemic local anesthetics. How, where, and when.
Cartilage toxicity from local anesthetics. Skeletal Radiol. 2008 Oct; 37(10):871-3.
Cartilage toxicity from local anesthetics.
Sodium channels in axons and glial cells of the optic nerve of Necturus maculosa. J Gen Physiol. 1979 Nov; 74(5):629-42.
Sodium channels in axons and glial cells of the optic nerve of Necturus maculosa.
Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster. Biochim Biophys Acta. 1980 Jan 25; 595(2):291-303.
Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster.
Effects of tertiary local anesthetics and their quaternary derivatives on sodium channels of nerve membranes [proceedings]. Biophys J. 1977 Jun; 18(3):353-4.
Effects of tertiary local anesthetics and their quaternary derivatives on sodium channels of nerve membranes [proceedings].
Shin HC, Park HJ, Raymond SA, Strichartz GR
Potentiation by capsaicin of lidocaine's tonic impulse block in isolated rat sciatic nerve. Neurosci Lett. 1994 Jun 06; 174(1):14-6.
Potentiation by capsaicin of lidocaine's tonic impulse block in isolated rat sciatic nerve.
The binding of labelled saxitoxin to mammalian non-myelinated nerve fibres. J Physiol. 1973 Jul; 232(1):53P-54P.
The binding of labelled saxitoxin to mammalian non-myelinated nerve fibres.
Block of human heart hH1 sodium channels by the enantiomers of bupivacaine. Anesthesiology. 2000 Oct; 93(4):1022-33.
Block of human heart hH1 sodium channels by the enantiomers of bupivacaine.
Wang ZY, Feng DM, Wang YL, Tung SR, Wong K, Strichartz GR, Folkers K, Håkanson R
Pharmacological assessment of spantide II analogues. Eur J Pharmacol. 1994 Aug 01; 260(2-3):121-8.
Pharmacological assessment of spantide II analogues.
Khodorova A, Fareed MU, Gokin A, Strichartz GR, Davar G
Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner. J Neurosci. 2002 Sep 01; 22(17):7788-96.
Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner.
Levobupivacaine versus ropivacaine for sciatic nerve block in the rat. Reg Anesth Pain Med. 2003 Jul-Aug; 28(4):294-303.
Levobupivacaine versus ropivacaine for sciatic nerve block in the rat.
Schreiber KL, Zinboonyahgoon N, Xu X, Spivey T, King T, Dominici L, Partridge A, Golshan M, Strichartz G, Edwards RR
Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery. J Pain. 2019 05; 20(5):540-556.
Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery.
Effects of deuterium oxide on the rate and dissociation constants for saxitoxin and tetrodotoxin action. Voltage-clamp studies on frog myelinated nerve. J Gen Physiol. 1981 Aug; 78(2):113-39.
Effects of deuterium oxide on the rate and dissociation constants for saxitoxin and tetrodotoxin action. Voltage-clamp studies on frog myelinated nerve.
Simultaneous modifications of sodium channel gating by two scorpion toxins. Biophys J. 1982 Nov; 40(2):175-9.
Simultaneous modifications of sodium channel gating by two scorpion toxins.
Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus. Mol Pharmacol. 1983 Mar; 23(2):519-33.
Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus.
Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR
Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology. 1995 Apr; 82(4):1013-25.
Neurologic evaluation of the rat during sciatic nerve block with lidocaine.
Saxitoxin binding in nerves from walking legs of the lobster Homarus americanus. Two classes of receptors. J Gen Physiol. 1981 Feb; 77(2):205-21.
Saxitoxin binding in nerves from walking legs of the lobster Homarus americanus. Two classes of receptors.
Jackson FR, Wilson SD, Strichartz GR, Hall LM
Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster. Nature. 1984 Mar 8-14; 308(5955):189-91.
Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster.
Li YM, Wingrove DE, Too HP, Marnerakis M, Stimson ER, Strichartz GR, Maggio JE
Local anesthetics inhibit substance P binding and evoked increases in intracellular Ca2+. Anesthesiology. 1995 Jan; 82(1):166-73.
Local anesthetics inhibit substance P binding and evoked increases in intracellular Ca2+.
Current concepts of the mechanism of action of local anesthetics. J Dent Res. 1981 Aug; 60(8):1460-70.
Current concepts of the mechanism of action of local anesthetics.
Popitz-Bergez FA, Leeson S, Strichartz GR, Thalhammer JG
Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. A study in the rat sciatic nerve. Anesthesiology. 1995 Sep; 83(3):583-92.
Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. A study in the rat sciatic nerve.
Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions. Anesth Analg. 2019 02; 128(2):199-201.
Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions.
Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature. Anesth Analg. 1987 Feb; 66(2):159-65.
Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature.
DeBin JA, Wood MR, Pfenninger KH, Strichartz GR
A chloride channel reconstituted from fetal rat brain growth cones. J Membr Biol. 1994 Jul; 141(1):7-19.
A chloride channel reconstituted from fetal rat brain growth cones.
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 1993 Feb; 264(2 Pt 1):C361-9.
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion.
Nandi M, Schreiber KL, Martel MO, Cornelius M, Campbell CM, Haythornthwaite JA, Smith MT, Wright J, Aglio LS, Strichartz G, Edwards RR
Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty. Biol Sex Differ. 2019 05 06; 10(1):23.
Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty.
Associate Professor of Dermatology, Part-time
Richard J. Kitz Professor of Anaesthesia Research
Zinboonyahgoon N, Vlassakov K, Lirk P, Spivey T, King T, Dominici L, Golshan M, Strichartz G, Edwards R, Schreiber K
Benefit of regional anaesthesia on postoperative pain following mastectomy: the influence of catastrophising. Br J Anaesth. 2019 08; 123(2):e293-e302.
Benefit of regional anaesthesia on postoperative pain following mastectomy: the influence of catastrophising.
Garibyan L, Moradi Tuchayi S, Wang Y, Khodorova A, Stemmer-Rachamimov A, Purschke M, Osseiran S, Evans CL, Mao J, Strichartz G, Anderson RR
Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model. Anesthesiology. 2020 07; 133(1):185-194.
Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model.
Barreveld A, Witte J, Chahal H, Durieux ME, Strichartz G
Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesth Analg. 2013 May; 116(5):1141-1161.
Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs.
Ohri R, Wang JC, Blaskovich PD, Pham LN, Costa DS, Nichols GA, Hildebrand WP, Scarborough NL, Herman CJ, Strichartz GR
Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. Anesth Analg. 2013 Sep; 117(3):717-730.
Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision.
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw. Neuroscience. 2013 Dec 19; 254:312-23.
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw.
Ohri R, Wang JC, Pham L, Blaskovich PD, Costa D, Nichols G, Hildebrand W, Scarborough N, Herman C, Strichartz GR
Prolonged amelioration of experimental postoperative pain by bupivacaine released from microsphere-coated hernia mesh. Reg Anesth Pain Med. 2014 Mar-Apr; 39(2):97-107.
Prolonged amelioration of experimental postoperative pain by bupivacaine released from microsphere-coated hernia mesh.
Barr TP, Hrnjic A, Khodorova A, Sprague JM, Strichartz GR
Sensitization of cutaneous neuronal purinergic receptors contributes to endothelin-1-induced mechanical hypersensitivity. Pain. 2014 Jun; 155(6):1091-1101.
Sensitization of cutaneous neuronal purinergic receptors contributes to endothelin-1-induced mechanical hypersensitivity.
Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J
Research at the Harvard Anesthesia Departments. Anesthesiology. 2014 Dec; 121(6):1141-3.
Research at the Harvard Anesthesia Departments.
Strichartz GR, Wang JC, Blaskovich P, Ohri R
Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres. Anesth Analg. 2015 Jun; 120(6):1375-84.
Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres.
Schmidt B, Ohri R, Wang JC, Blaskovich P, Kesselring A, Scarborough N, Herman C, Strichartz G
Local pathology and systemic serum bupivacaine after subcutaneous delivery of slow-releasing bupivacaine microspheres. Anesth Analg. 2015 Jan; 120(1):36-44.
Local pathology and systemic serum bupivacaine after subcutaneous delivery of slow-releasing bupivacaine microspheres.
Cassinello F, Prieto I, del Olmo M, Rivas S, Strichartz GR
Cancer surgery: how may anesthesia influence outcome? J Clin Anesth. 2015 May; 27(3):262-72.
Cancer surgery: how may anesthesia influence outcome?
Makdessi MJ, Barr TP, Xue W, Strichartz GR
Bupivacaine inhibits endothelin-1-evoked increases in intracellular calcium in model sensory neurons. Acta Anaesthesiol Scand. 2015 Aug; 59(7):936-45.
Bupivacaine inhibits endothelin-1-evoked increases in intracellular calcium in model sensory neurons.
Systemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats. Anesth Analg. 2015 Aug; 121(2):545-55.
Systemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats.
Wang CF, Russell G, Strichartz GR, Wang GK
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model. Anesth Analg. 2015 Aug; 121(2):532-44.
The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model.
Spontaneous Chronic Pain After Experimental Thoracotomy Revealed by Conditioned Place Preference: Morphine Differentiates Tactile Evoked Pain From Spontaneous Pain. J Pain. 2015 Sep; 16(9):903-12.
Spontaneous Chronic Pain After Experimental Thoracotomy Revealed by Conditioned Place Preference: Morphine Differentiates Tactile Evoked Pain From Spontaneous Pain.
Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect. Anesthesiology. 2015 Oct; 123(4):A23.
Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect.
Strichartz GR, Khodorova A, Wang JC, Chen YW, Huang CC
Contralateral Hyperalgesia from Injection of Endothelin-1 into the Ipsilateral Paw Requires Efferent Conduction into the Contralateral Paw. Anesth Analg. 2015 Oct; 121(4):1065-1077.
Contralateral Hyperalgesia from Injection of Endothelin-1 into the Ipsilateral Paw Requires Efferent Conduction into the Contralateral Paw.
Wang CF, Russell G, Wang SY, Strichartz GR, Wang GK
R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. Anesth Analg. 2016 Mar; 122(3):719-729.
R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain.
Barr TP, Kornberg D, Montmayeur JP, Long M, Reichheld S, Strichartz GR
Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. Anal Biochem. 2015 01 01; 468:28-33.
Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot.
Local Anesthetic Interactions with Membranes
Endothelin Mechanisms in Metastic Prostate Cancer Pain
Endothelin mechanisms in metastic prostate cancer pain
ANESTHESIOLOGY CENTER FOR TEACHING AND RESEARCH
CONTROL OF NEURAL FUNCTION IN ANESTHESIA
Chi-Fei Wang J, Hung CH, Gerner P, Ji RR, Strichartz GR
The Qualitative Hyperalgesia Profile: A New Metric to Assess Chronic Post-Thoracotomy Pain. Open Pain J. 2013; 6:190-198.
The Qualitative Hyperalgesia Profile: A New Metric to Assess Chronic Post-Thoracotomy Pain.
Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology
State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution. Biochem (Mosc) Suppl Ser A Membr Cell Biol. 2012 Apr; 6(2):120-127.
Biochem (Mosc) Suppl Ser A Membr Cell Biol
State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution.
Khodorova A, Zou S, Ren K, Dubner R, Davar G, Strichartz G
Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats. Open Pain J. 2009; 2:30-40.
Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats.
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. Neuroscience. 2017 01 06; 340:384-397.
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor.
Prevention of Chronic Post-Thoracotomy Pain in Rats By Intrathecal Resolvin D1 and D2: Effectiveness of Perioperative and Delayed Drug Delivery. J Pain. 2017 05; 18(5):535-545.
Prevention of Chronic Post-Thoracotomy Pain in Rats By Intrathecal Resolvin D1 and D2: Effectiveness of Perioperative and Delayed Drug Delivery.
Nandi M, Cornelius M, Campbell C, Smith M, Haythornthwaite J, Wright J, Edwards R, Strichartz G
The journal of pain : official journal of the American Pain Society
(103) Sex differences in pain and functioning among Total Knee Arthroplasty patients. J Pain. 2016 Apr; 17(4S):S1-S2.
(103) Sex differences in pain and functioning among Total Knee Arthroplasty patients.
Waikar SS, Thalhammer JG, Raymond SA, Huang JH, Chang DS, Strichartz GR
Mechanoreceptive afferents exhibit functionally-specific activity dependent changes in conduction velocity. Brain Res. 1996 May 20; 721(1-2):91-100.
Mechanoreceptive afferents exhibit functionally-specific activity dependent changes in conduction velocity.
Radicular irritation after spinal anesthesia. Anesthesiology. 1996 Nov; 85(5):1216-7.
Radicular irritation after spinal anesthesia.
Huang JH, Thalhammer JG, Raymond SA, Strichartz GR
Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve. J Pharmacol Exp Ther. 1997 Aug; 282(2):802-11.
Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve.
Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Mol Pharmacol. 1999 Aug; 56(2):404-13.
Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.
Sinnott CJ, Garfield JM, Thalhammer JG, Strichartz GR
Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in the rat. Anesthesiology. 2000 Oct; 93(4):1045-52.
Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in the rat.
Khodorova A, Navarro B, Jouaville LS, Murphy JE, Rice FL, Mazurkiewicz JE, Long-Woodward D, Stoffel M, Strichartz GR, Yukhananov R, Davar G
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med. 2003 Aug; 9(8):1055-61.
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury.
Lee-Son S, Wang GK, Concus A, Crill E, Strichartz G
Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action? Anesthesiology. 1992 Aug; 77(2):324-35.
Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action?
Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin. Pain. 2002 Sep; 99(1-2):333-40.
Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin.
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Questioning the mechanism of nerve injury. Anesthesiology. 2004 Nov; 101(5):1249; author reply 1249-50.
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Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells.
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Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat.
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Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies.
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Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med. 2006 Jul-Aug; 31(4):296-303.
Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart.
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The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix. Anesth Analg. 2010 Jul; 111(1):221-9.
The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix.
Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. J Neurosci. 2002 Aug 01; 22(15):6325-30.
Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1.
Local anesthetics inhibit the G protein-mediated modulation of K+ and Ca++ currents in anterior pituitary cells. Mol Pharmacol. 1999 Jan; 55(1):150-8.
Local anesthetics inhibit the G protein-mediated modulation of K+ and Ca++ currents in anterior pituitary cells.
Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M
Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res. 2000 Jun 01; 60(5):666-77.
Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap.
Acute effects of repetitive depolarization on sodium current in chick myocytes. Am J Physiol. 1991 Jun; 260(6 Pt 2):H1810-8.
Acute effects of repetitive depolarization on sodium current in chick myocytes.
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The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat. Anesthesiology. 2003 Nov; 99(5):1189-97.
The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat.
Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors. Anesthesiology. 2006 Apr; 104(4):805-14.
Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors.
Experimental biology and medicine (Maywood, N.J.)
Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors. Exp Biol Med (Maywood). 2006 Jun; 231(6):1165-70.
Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors.
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A role for nk-1 neurons in the rostral ventromedial medulla in the development of chronic post-thoracotomy pain. Pain. 2017 Apr 05.
A role for nk-1 neurons in the rostral ventromedial medulla in the development of chronic post-thoracotomy pain.
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Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus. Toxicon. 1991; 29(11):1403-8.
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Beta-estradiol acutely potentiates the depression of cardiac excitability by lidocaine and bupivacaine. J Cardiovasc Pharmacol. 1999 Nov; 34(5):718-27.
Beta-estradiol acutely potentiates the depression of cardiac excitability by lidocaine and bupivacaine.
The addition of dilute epinephrine produces equieffectiveness of bupivacaine enantiomers for cutaneous analgesia in the rat. Anesth Analg. 2000 Aug; 91(2):410-6.
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Pathways and obstacles to local anesthesia, a personal account: the 2000 Gaston Labat lecture. Reg Anesth Pain Med. 2000 Sep-Oct; 25(5):447-51.
Pathways and obstacles to local anesthesia, a personal account: the 2000 Gaston Labat lecture.
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Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats.
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Prolonged cutaneous analgesia with transdermal application of amitriptyline and capsaicin. Reg Anesth Pain Med. 2011 May-Jun; 36(3):236-40.
Prolonged cutaneous analgesia with transdermal application of amitriptyline and capsaicin.
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Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons.
Kinetics of uptake and washout of lidocaine in rat sciatic nerve in vitro. Anesth Analg. 2013 Mar; 116(3):694-702.
Kinetics of uptake and washout of lidocaine in rat sciatic nerve in vitro.
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Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats. Life Sci. 1997; 61(12):PL 177-84.
Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats.
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In defense of in vitro findings. Anesthesiology. 2004 Nov; 101(5):1246-7; author reply 1247-8.
Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci. 2006 Mar 29; 26(13):3551-60.
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
Cogswell LP, Raines DE, Parekh S, Jonas O, Maggio JE, Strichartz GR
Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein. J Pharm Sci. 2001 Sep; 90(9):1407-23.
Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.
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Limited nerve impulse blockade by "leashed" local anesthetics. J Med Chem. 1987 Aug; 30(8):1295-302.
Limited nerve impulse blockade by "leashed" local anesthetics.
Through the eye of the channel: considerations of a reductionist view of general anesthesia. Anesthesiology. 1988 Aug; 69(2):155-6.
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The role of length of nerve exposed to local anesthetics in impulse blocking action. Anesth Analg. 1989 May; 68(5):563-70.
The role of length of nerve exposed to local anesthetics in impulse blocking action.
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On the mechanism by which epinephrine potentiates lidocaine's peripheral nerve block. Anesthesiology. 2003 Jan; 98(1):181-8.
On the mechanism by which epinephrine potentiates lidocaine's peripheral nerve block.
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Intraneural lidocaine uptake compared with analgesic differences between pregnant and nonpregnant rats. Reg Anesth. 1997 Jul-Aug; 22(4):363-71.
Intraneural lidocaine uptake compared with analgesic differences between pregnant and nonpregnant rats.
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Molecular mechanisms of local anesthesia: a review. Anesthesiology. 1990 Apr; 72(4):711-34.
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Kinetic analysis of the action of Leiurus scorpion alpha-toxin on ionic currents in myelinated nerve. J Gen Physiol. 1985 Nov; 86(5):739-62.
Kinetic analysis of the action of Leiurus scorpion alpha-toxin on ionic currents in myelinated nerve.
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MAP kinase and pain. Brain Res Rev. 2009 Apr; 60(1):135-48.
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Khasabov SG, Wang JC, Simone DA, Strichartz GR
A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain. Pain. 2017 07; 158(7):1332-1341.
A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain.
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Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves.
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Focused ultrasound effects on nerve action potential in vitro.
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Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein.
Canadian journal of physiology and pharmacology
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Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Pain. 2011 Mar; 152(3):557-565.
Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1.
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Proceedings of the Royal Society of London. Series B, Biological sciences
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ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Ga(q/11). Pharmacol Res. 2011 Sep; 64(3):258-67.
ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Ga(q/11).
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On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve.
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Journal of negative results in biomedicine
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Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane.
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Sodium-channel inhibitors produced by enteropathogenic Vibrio cholerae and Aeromonas hydrophila. Lancet. 1987 Apr 25; 1(8539):975.
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Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain. Br J Anaesth. 2008 Jul; 101(1):45-7.
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Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs. Anesth Analg. 1990 Aug; 71(2):158-70.
Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs.
Kays J, Zhang YH, Khorodova A, Strichartz G, Nicol GD
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor. Neuroscience. 2018 02 10; 371:420-432.
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Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.
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Neurophysiologic actions and neurological consequences of veratridine on the rat sciatic nerve.
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A re-examination of tetrodotoxin for prolonged duration local anesthesia.
A preferential inhibition of impulses in C-fibers of the rabbit vagus nerve by veratridine, an activator of sodium channels. Anesthesiology. 1991 Feb; 74(2):270-80.
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Antagonism by local anesthetics of sodium channel activators in the presence of scorpion toxins: two mechanisms for competitive inhibition.
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Behavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerve.
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Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol. 1998 Dec; 154(2):315-29.
Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft.
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Local anaesthetic drugs--an historical perspective.
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Alterations in sodium channel gating produced by the venom of the marine mollusc Conus striatus. Toxicon. 1991; 29(2):245-59.
Alterations in sodium channel gating produced by the venom of the marine mollusc Conus striatus.