Hartwig, John
completed student projects: What Is the Role of Filamin 1 in Myeloid Cell Function?
completed student projects: The Relationship between Mutacin Production and Early Childhood Caries
completed student projects: Role of Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
completed student projects: The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
completed student projects: The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix Complex in the Human Platelet
completed student projects: role of teh Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
completed student projects: Outside-In Integration Signaling Accelerates Platelet Action Filament Turnover
completed student projects: What is the Role of Filamin 1 in Myeloid Cell Function?
completed student projects: The Relationship Between Filamin B, an Actin-binding Protein isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
completed student projects: Impact of Limited English and Physician Language Concordance on Health Care Delivery and Patient Satisfaction
completed student projects: Role of the Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
completed student projects: Regulatory T cells in Merkel Cell Carcinoma
eCommons Login: JHH1
first name: John
last name: Hartwig
coauthor of: Italiano, Joseph
coauthor of: Geha, Raif
coauthor of: Wagner, Denisa
coauthor of: Kwiatkowski, David
coauthor of: Osborn, Eric
full name: John Henry Hartwig, Ph.D.
has faculty rank: Full Professor
has network: selected publications
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latitude: 42.33812600000000
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Person ID: 81584
person in primary position: Professor of Medicine, Emeritus
physical neighbor: Bunn, Howard
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similar to: Italiano, Joseph
similar to: Mitchison, Timothy
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type: Agent
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selected publications: Authorship 1065812
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selected publications: Authorship 278494
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selected publications: Authorship 380412
selected publications: Authorship 224636

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https://connects.catalyst.harvard.edu/Profiles/profile/1000146
PubMed Identifier: 124735
author list: Stossel TP, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin. J Biol Chem. 1975 Jul 25; 250(14):5706-12.
journal title abbreviation: J Biol Chem
publication date: 1975-07-25T00:00:00
year: 1975
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin.

Filamins as integrators of cell mechanics and signalling.
PubMed Identifier: 11252955
author list: Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS
published in: Nature reviews. Molecular cell biology
information resource reference: Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol. 2001 Feb; 2(2):138-45.
journal title abbreviation: Nat Rev Mol Cell Biol
publication date: 2001-02-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation.
PubMed Identifier: 10753840
author list: Sobocka MB, Sobocki T, Banerjee P, Weiss C, Rushbrook JI, Norin AJ, Hartwig J, Salifu MO, Markell MS, Babinska A, Ehrlich YH, Kornecki E
published in: Blood
information resource reference: Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood. 2000 Apr 15; 95(8):2600-9.
journal title abbreviation: Blood
publication date: 2000-04-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages.
PubMed Identifier: 3745263
author list: Hartwig JH, Shevlin P
published in: The Journal of cell biology
information resource reference: The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages. J Cell Biol. 1986 Sep; 103(3):1007-20.
journal title abbreviation: J Cell Biol
publication date: 1986-09-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1050906
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Sarcomeric and nonmuscle a-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines.

Sarcomeric and nonmuscle a-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines.
PubMed Identifier: 29518289
author list: Hsu CP, Moghadaszadeh B, Hartwig JH, Beggs AH
published in: Cytoskeleton (Hoboken, N.J.)
information resource reference: Sarcomeric and nonmuscle a-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines. Cytoskeleton (Hoboken). 2018 05; 75(5):213-228.
journal title abbreviation: Cytoskeleton (Hoboken)
publication date: 2018-04-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin cytoskeleton. Setting the pace of cell movement.
PubMed Identifier: 8542272
author list: Barkalow K, Hartwig JH
published in: Current biology : CB
information resource reference: Actin cytoskeleton. Setting the pace of cell movement. Curr Biol. 1995 Sep 01; 5(9):1000-2.
journal title abbreviation: Curr Biol
publication date: 1995-09-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Three-dimensional reconstruction of the actin cytoskeleton from stereo images.
PubMed Identifier: 10609523
author list: Cheng Y, Hartemink CA, Hartwig JH, Dewey CF
published in: Journal of biomechanics
information resource reference: Three-dimensional reconstruction of the actin cytoskeleton from stereo images. J Biomech. 2000 Jan; 33(1):105-13.
journal title abbreviation: J Biomech
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.
PubMed Identifier: 8707824
author list: Barkalow K, Witke W, Kwiatkowski DJ, Hartwig JH
published in: The Journal of cell biology
information resource reference: Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol. 1996 Jul; 134(2):389-99.
journal title abbreviation: J Cell Biol
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
PubMed Identifier: 2391361
author list: Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH
published in: The Journal of cell biology
information resource reference: Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990 Sep; 111(3):1089-105.
journal title abbreviation: J Cell Biol
publication date: 1990-09-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Transfusion medicine illustrated. The human blood platelet, resting and active.
PubMed Identifier: 11399808
author list: Hartwig J
published in: Transfusion
information resource reference: Transfusion medicine illustrated. The human blood platelet, resting and active. Transfusion. 2001 Jun; 41(6):723.
journal title abbreviation: Transfusion
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Filling gaps in signaling to actin cytoskeletal remodeling.
PubMed Identifier: 12689583
author list: Stossel TP, Hartwig JH
published in: Developmental cell
information resource reference: Filling gaps in signaling to actin cytoskeletal remodeling. Dev Cell. 2003 Apr; 4(4):444-5.
journal title abbreviation: Dev Cell
publication date: 2003-04-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics.
PubMed Identifier: 15901596
author list: Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH
published in: American journal of physiology. Cell physiology
information resource reference: Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C819-25.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2005-05-18T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments.
PubMed Identifier: 6893990
author list: Hartwig JH, Tyler J, Stossel TP
published in: The Journal of cell biology
information resource reference: Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J Cell Biol. 1980 Dec; 87(3 Pt 1):841-8.
journal title abbreviation: J Cell Biol
publication date: 1980-12-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1065812
type: Authorship
author rank in publication: 11
linked author: Hartwig, John
linked information resource: Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.

Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.
PubMed Identifier: 29739775
author list: Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B
published in: Blood advances
information resource reference: Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. Blood Adv. 2018 05 08; 2(9):1040-1045.
journal title abbreviation: Blood Adv
publication date: 2018-05-08T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
PubMed Identifier: 19293932
author list: Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP
published in: PloS one
information resource reference: Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One. 2009; 4(3):e4928.
journal title abbreviation: PLoS One
publication date: 2009-03-18T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.
PubMed Identifier: 12907434
author list: Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD
published in: Blood
information resource reference: Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood. 2003 Dec 01; 102(12):4229-35.
journal title abbreviation: Blood
publication date: 2003-08-07T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The structure of the macrophage actin skeleton.
PubMed Identifier: 2855803
author list: Yin HL, Hartwig JH
published in: Journal of cell science. Supplement
information resource reference: The structure of the macrophage actin skeleton. J Cell Sci Suppl. 1988; 9:169-84.
journal title abbreviation: J Cell Sci Suppl
publication date: 1988-01-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 106419
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Isolation of actin-binding protein and villin from toad oocytes.

Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin.
PubMed Identifier: 23041423
author list: Suphamungmee W, Nakamura F, Hartwig JH, Lehman W
published in: Journal of molecular biology
information resource reference: Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin. J Mol Biol. 2012 Dec 14; 424(5):248-56.
journal title abbreviation: J Mol Biol
publication date: 2012-10-04T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets.
PubMed Identifier: 11369202
author list: Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA
published in: Current biology : CB
information resource reference: A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86.
journal title abbreviation: Curr Biol
publication date: 2001-04-17T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.
PubMed Identifier: 11869681
author list: Antón IM, de la Fuente MA, Sims TN, Freeman S, Ramesh N, Hartwig JH, Dustin ML, Geha RS
published in: Immunity
information resource reference: WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity. 2002 Feb; 16(2):193-204.
journal title abbreviation: Immunity
publication date: 2002-02-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
PubMed Identifier: 20713593
author list: Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH
published in: The Journal of experimental medicine
information resource reference: A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30; 207(9):1967-79.
journal title abbreviation: J Exp Med
publication date: 2010-08-16T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.
PubMed Identifier: 22596262
author list: Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD
published in: Blood
information resource reference: Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28; 119(26):6335-43.
journal title abbreviation: Blood
publication date: 2012-05-17T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The effect of filament shortening on the mechanical properties of gel-filtered actin.
PubMed Identifier: 3350801
author list: Zaner KS, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: The effect of filament shortening on the mechanical properties of gel-filtered actin. J Biol Chem. 1988 Apr 05; 263(10):4532-6.
journal title abbreviation: J Biol Chem
publication date: 1988-04-05T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

The gelation of actin by actin-binding protein.
PubMed Identifier: 721823
author list: Brotschi EA, Hartwig JH, Stossel TP
published in: The Journal of biological chemistry
information resource reference: The gelation of actin by actin-binding protein. J Biol Chem. 1978 Dec 25; 253(24):8988-93.
journal title abbreviation: J Biol Chem
publication date: 1978-12-25T00:00:00
year: 1978
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell mechanics: Contracting to stiffness.
PubMed Identifier: 21157494
author list: Ehrlicher A, Hartwig JH
published in: Nature materials
information resource reference: Cell mechanics: Contracting to stiffness. Nat Mater. 2011 Jan; 10(1):12-3.
journal title abbreviation: Nat Mater
publication date: 2011-01-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.
PubMed Identifier: 21709252
author list: Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11464-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2011-06-27T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanisms of organelle transport and capture along proplatelets during platelet production.
PubMed Identifier: 16118320
author list: Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE
published in: Blood
information resource reference: Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75.
journal title abbreviation: Blood
publication date: 2005-08-23T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function.
PubMed Identifier: 16254049
author list: Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16263-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-10-27T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell surface actin remodeling.
PubMed Identifier: 16899816
author list: Stossel TP, Fenteany G, Hartwig JH
published in: Journal of cell science
information resource reference: Cell surface actin remodeling. J Cell Sci. 2006 Aug 15; 119(Pt 16):3261-4.
journal title abbreviation: J Cell Sci
publication date: 2006-08-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 11189
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase.

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.
PubMed Identifier: 16882712
author list: Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y
published in: Blood
information resource reference: Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006 Dec 01; 108(12):3637-45.
journal title abbreviation: Blood
publication date: 2006-08-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

The origin and function of platelet glycosyltransferases.
PubMed Identifier: 22613794
author list: Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE, Clausen H, Hartwig JH, Hoffmeister KM
published in: Blood
information resource reference: The origin and function of platelet glycosyltransferases. Blood. 2012 Jul 19; 120(3):626-35.
journal title abbreviation: Blood
publication date: 2012-05-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin.
PubMed Identifier: 7720072
author list: Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ
published in: Cell
information resource reference: Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 07; 81(1):41-51.
journal title abbreviation: Cell
publication date: 1995-04-07T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase.
PubMed Identifier: 8662682
author list: Ohta Y, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase. J Biol Chem. 1996 May 17; 271(20):11858-64.
journal title abbreviation: J Biol Chem
publication date: 1996-05-17T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural basis of filamin A functions.
PubMed Identifier: 18056414
author list: Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP
published in: The Journal of cell biology
information resource reference: Structural basis of filamin A functions. J Cell Biol. 2007 Dec 03; 179(5):1011-25.
journal title abbreviation: J Cell Biol
publication date: 2007-12-03T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Macrophages: their use in elucidation of the cytoskeletal roles of actin.
PubMed Identifier: 6287163
author list: Hartwig JH, Stossel TP
published in: Methods in cell biology
information resource reference: Macrophages: their use in elucidation of the cytoskeletal roles of actin. Methods Cell Biol. 1982; 25 Pt B:201-25.
journal title abbreviation: Methods Cell Biol
publication date: 1982-01-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP is critical for T cell responsiveness to IL-2.
PubMed Identifier: 19359486
author list: Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7519-24.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2009-04-09T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.
PubMed Identifier: 2537317
author list: Hartwig JH, Chambers KA, Stossel TP
published in: The Journal of cell biology
information resource reference: Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol. 1989 Feb; 108(2):467-79.
journal title abbreviation: J Cell Biol
publication date: 1989-02-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope.
PubMed Identifier: 2557160
author list: Holtz D, Tanaka RA, Hartwig J, McKeon F
published in: Cell
information resource reference: The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope. Cell. 1989 Dec 22; 59(6):969-77.
journal title abbreviation: Cell
publication date: 1989-12-22T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Filamins in cell signaling, transcription and organ development.
PubMed Identifier: 20061151
author list: Zhou AX, Hartwig JH, Akyürek LM
published in: Trends in cell biology
information resource reference: Filamins in cell signaling, transcription and organ development. Trends Cell Biol. 2010 Feb; 20(2):113-23.
journal title abbreviation: Trends Cell Biol
publication date: 2010-01-12T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular DNA traps promote thrombosis.
PubMed Identifier: 20798043
author list: Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15880-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-08-23T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential interaction of the C3b/C4b receptor and MHC class I with the cytoskeleton of human neutrophils.
PubMed Identifier: 2946771
author list: Jack RM, Ezzell RM, Hartwig J, Fearon DT
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Differential interaction of the C3b/C4b receptor and MHC class I with the cytoskeleton of human neutrophils. J Immunol. 1986 Dec 15; 137(12):3996-4003.
journal title abbreviation: J Immunol
publication date: 1986-12-15T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin polymerization stabilizes a4ß1 integrin anchors that mediate monocyte adhesion.
PubMed Identifier: 22472442
author list: Rullo J, Becker H, Hyduk SJ, Wong JC, Digby G, Arora PD, Cano AP, Hartwig J, McCulloch CA, Cybulsky MI
published in: The Journal of cell biology
information resource reference: Actin polymerization stabilizes a4ß1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012 Apr 02; 197(1):115-29.
journal title abbreviation: J Cell Biol
publication date: 2012-04-02T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The cortical actin networks of migrating human PMNs.
PubMed Identifier: 6218279
author list: Niederman R, Ryder MI, Horton JE, Sullivan T, Peters L, Hartwig J, Stossel TP
published in: Journal of periodontal research
information resource reference: The cortical actin networks of migrating human PMNs. J Periodontal Res. 1982 Sep; 17(5):487-91.
journal title abbreviation: J Periodontal Res
publication date: 1982-09-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Macrophage actin-binding protein.
PubMed Identifier: 7121283
author list: Hartwig JH, Stossel TP
published in: Methods in enzymology
information resource reference: Macrophage actin-binding protein. Methods Enzymol. 1982; 85 Pt B:480-8.
journal title abbreviation: Methods Enzymol
publication date: 1982-01-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanism of shape change in chilled human platelets.
PubMed Identifier: 7703486
author list: Winokur R, Hartwig JH
published in: Blood
information resource reference: Mechanism of shape change in chilled human platelets. Blood. 1995 Apr 01; 85(7):1796-804.
journal title abbreviation: Blood
publication date: 1995-04-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro.
PubMed Identifier: 7756305
author list: Ohta Y, Hartwig JH
published in: Biochemistry
information resource reference: Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro. Biochemistry. 1995 May 23; 34(20):6745-54.
journal title abbreviation: Biochemistry
publication date: 1995-05-23T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanics of proplatelet elaboration.
PubMed Identifier: 17635704
author list: Italiano JE, Patel-Hett S, Hartwig JH
published in: Journal of thrombosis and haemostasis : JTH
information resource reference: Mechanics of proplatelet elaboration. J Thromb Haemost. 2007 Jul; 5 Suppl 1:18-23.
journal title abbreviation: J Thromb Haemost
publication date: 2007-07-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The motor of leukocytes.
PubMed Identifier: 6540718
author list: Stossel TP, Hartwig JH, Yin HL, Southwick FS, Zaner KS
published in: Federation proceedings
information resource reference: The motor of leukocytes. Fed Proc. 1984 Sep; 43(12):2760-3.
journal title abbreviation: Fed Proc
publication date: 1984-09-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments.
PubMed Identifier: 6894945
author list: Hartwig JH, Stossel TP
published in: Journal of molecular biology
information resource reference: Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments. J Mol Biol. 1981 Jan 25; 145(3):563-81.
journal title abbreviation: J Mol Biol
publication date: 1981-01-25T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of actin filament barbed-end exposure in cytoskeletal dynamics and cell motility.
PubMed Identifier: 8566341
author list: Barkalow K, Hartwig JH
published in: Biochemical Society transactions
information resource reference: The role of actin filament barbed-end exposure in cytoskeletal dynamics and cell motility. Biochem Soc Trans. 1995 Aug; 23(3):451-6.
journal title abbreviation: Biochem Soc Trans
publication date: 1995-08-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer.
PubMed Identifier: 7561081
author list: Hartwig JH, Jugloff LS, De Groot NJ, Grupp SA, Jongstra-Bilen J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer. J Immunol. 1995 Oct 15; 155(8):3769-79.
journal title abbreviation: J Immunol
publication date: 1995-10-15T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Interpreting photoactivated fluorescence microscopy measurements of steady-state actin dynamics.
PubMed Identifier: 8580311
author list: Tardy Y, McGrath JL, Hartwig JH, Dewey CF
published in: Biophysical journal
information resource reference: Interpreting photoactivated fluorescence microscopy measurements of steady-state actin dynamics. Biophys J. 1995 Nov; 69(5):1674-82.
journal title abbreviation: Biophys J
publication date: 1995-11-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin-binding proteins 1: spectrin superfamily.
PubMed Identifier: 8624824
author list: Hartwig JH
published in: Protein profile
information resource reference: Actin-binding proteins 1: spectrin superfamily. Protein Profile. 1994; 1(7):706-78.
journal title abbreviation: Protein Profile
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.
PubMed Identifier: 18772378
author list: Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14064-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-09-04T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 125605
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: The cortical actin networks of migrating human PMNs.

Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.
PubMed Identifier: 20585041
author list: Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM
published in: Blood
information resource reference: Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Blood. 2010 Oct 07; 116(14):2590-9.
journal title abbreviation: Blood
publication date: 2010-06-28T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.
PubMed Identifier: 21652675
author list: Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H
published in: Blood
information resource reference: FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011 Aug 25; 118(8):2285-95.
journal title abbreviation: Blood
publication date: 2011-06-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis.
PubMed Identifier: 4334720
author list: Stossel TP, Mason RJ, Hartwig J, Vaughan M
published in: The Journal of clinical investigation
information resource reference: Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest. 1972 Mar; 51(3):615-24.
journal title abbreviation: J Clin Invest
publication date: 1972-03-01T00:00:00
year: 1972
type: Academic Article
type: Article
type: Document
type: Information Resource

Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.
PubMed Identifier: 1035911
author list: Stossel TP, Hartwig JH
published in: The Journal of cell biology
information resource reference: Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis. J Cell Biol. 1976 Mar; 68(3):602-19.
journal title abbreviation: J Cell Biol
publication date: 1976-03-01T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
PubMed Identifier: 10679324
author list: Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL
published in: Current biology : CB
information resource reference: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6.
journal title abbreviation: Curr Biol
publication date: 2000-02-10T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Cortical actin structures and their relationship to mammalian cell movements.
PubMed Identifier: 3904083
author list: Hartwig JH, Niederman R, Lind SE
published in: Sub-cellular biochemistry
information resource reference: Cortical actin structures and their relationship to mammalian cell movements. Subcell Biochem. 1985; 11:1-49.
journal title abbreviation: Subcell Biochem
publication date: 1985-01-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

How phagocytic leukocytes move.
PubMed Identifier: 6631336
author list: Hartwig JH, Yin HL, Stossel TP
published in: Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie
information resource reference: How phagocytic leukocytes move. J Clin Chem Clin Biochem. 1983 Sep; 21(9):535-44.
journal title abbreviation: J Clin Chem Clin Biochem
publication date: 1983-09-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis.
PubMed Identifier: 7016336
author list: Valerius NH, Stendahl O, Hartwig JH, Stossel TP
published in: Cell
information resource reference: Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Cell. 1981 Apr; 24(1):195-202.
journal title abbreviation: Cell
publication date: 1981-04-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
PubMed Identifier: 7493994
author list: Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ
published in: The Journal of biological chemistry
information resource reference: Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995 Dec 08; 270(49):29525-31.
journal title abbreviation: J Biol Chem
publication date: 1995-12-08T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28.
PubMed Identifier: 8406501
author list: Gorlin JB, Henske E, Warren ST, Kunst CB, D'Urso M, Palmieri G, Hartwig JH, Bruns G, Kwiatkowski DJ
published in: Genomics
information resource reference: Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 1993 Aug; 17(2):496-8.
journal title abbreviation: Genomics
publication date: 1993-08-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation.
PubMed Identifier: 8555484
author list: Kovacsovics TJ, Hartwig JH
published in: Blood
information resource reference: Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood. 1996 Jan 15; 87(2):618-29.
journal title abbreviation: Blood
publication date: 1996-01-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Interactions of tensin with actin and identification of its three distinct actin-binding domains.
PubMed Identifier: 8195290
author list: Lo SH, Janmey PA, Hartwig JH, Chen LB
published in: The Journal of cell biology
information resource reference: Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol. 1994 Jun; 125(5):1067-75.
journal title abbreviation: J Cell Biol
publication date: 1994-06-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The motor of amoeboid leucocytes.
PubMed Identifier: 6260107
author list: Stossel TP, Hartwig JH, Yin HL, Stendahl O
published in: Biochemical Society symposium
information resource reference: The motor of amoeboid leucocytes. Biochem Soc Symp. 1980; 45:51-63.
journal title abbreviation: Biochem Soc Symp
publication date: 1980-01-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons.
PubMed Identifier: 2642389
author list: Hartwig JH, Janmey PA
published in: Biochimica et biophysica acta
information resource reference: Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons. Biochim Biophys Acta. 1989 Jan 17; 1010(1):64-71.
journal title abbreviation: Biochim Biophys Acta
publication date: 1989-01-17T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Microtubule and cortical forces determine platelet size during vascular platelet production.
PubMed Identifier: 22617292
author list: Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE
published in: Nature communications
information resource reference: Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012 May 22; 3:852.
journal title abbreviation: Nat Commun
publication date: 2012-05-22T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.
PubMed Identifier: 7503723
author list: Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS
published in: Biochemical and biophysical research communications
information resource reference: Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14; 217(2):466-74.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1995-12-14T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets.
PubMed Identifier: 7664343
author list: Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP
published in: Cell
information resource reference: Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 1995 Aug 25; 82(4):643-53.
journal title abbreviation: Cell
publication date: 1995-08-25T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization.
PubMed Identifier: 8071358
author list: Lo SH, An Q, Bao S, Wong WK, Liu Y, Janmey PA, Hartwig JH, Chen LB
published in: The Journal of biological chemistry
information resource reference: Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. J Biol Chem. 1994 Sep 02; 269(35):22310-9.
journal title abbreviation: J Biol Chem
publication date: 1994-09-02T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells.
PubMed Identifier: 8383118
author list: Cantiello HF, Prat AG, Bonventre JV, Cunningham CC, Hartwig JH, Ausiello DA
published in: The Journal of biological chemistry
information resource reference: Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells. J Biol Chem. 1993 Mar 05; 268(7):4596-9.
journal title abbreviation: J Biol Chem
publication date: 1993-03-05T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells.
PubMed Identifier: 9746549
author list: McGrath JL, Tardy Y, Dewey CF, Meister JJ, Hartwig JH
published in: Biophysical journal
information resource reference: Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells. Biophys J. 1998 Oct; 75(4):2070-8.
journal title abbreviation: Biophys J
publication date: 1998-10-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
PubMed Identifier: 12743105
author list: Barkalow KL, Italiano JE, Chou DE, Matsuoka Y, Bennett V, Hartwig JH
published in: The Journal of cell biology
information resource reference: Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol. 2003 May 12; 161(3):557-70.
journal title abbreviation: J Cell Biol
publication date: 2003-05-12T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Polarization of gelsolin and actin binding protein in kidney epithelial cells.
PubMed Identifier: 2164058
author list: Hartwig JH, Brown D, Ausiello DA, Stossel TP, Orci L
published in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
information resource reference: Polarization of gelsolin and actin binding protein in kidney epithelial cells. J Histochem Cytochem. 1990 Aug; 38(8):1145-53.
journal title abbreviation: J Histochem Cytochem
publication date: 1990-08-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis.
PubMed Identifier: 6991506
author list: Stendahl OI, Hartwig JH, Brotschi EA, Stossel TP
published in: The Journal of cell biology
information resource reference: Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis. J Cell Biol. 1980 Feb; 84(2):215-24.
journal title abbreviation: J Cell Biol
publication date: 1980-02-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 114059
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages.

Authorship 114713
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase).

Cytoskeleton
MeSH DescriptorUI: D003599
MeSH semantic group name: Anatomy
number of authors: 501
number of publications: 1216
uniqueness weight: 0.676042
type: Concept

Microfilament Proteins
MeSH DescriptorUI: D008840
MeSH semantic group name: Chemicals & Drugs
number of authors: 597
number of publications: 1127
uniqueness weight: 0.680767
type: Concept

Blood Platelets
MeSH DescriptorUI: D001792
MeSH semantic group name: Anatomy
number of authors: 739
number of publications: 2475
uniqueness weight: 0.465124
type: Concept

Actins
MeSH DescriptorUI: D000199
MeSH semantic group name: Chemicals & Drugs
number of authors: 842
number of publications: 2063
uniqueness weight: 0.58945
type: Concept

Contractile Proteins
MeSH DescriptorUI: D003285
MeSH semantic group name: Chemicals & Drugs
number of authors: 112
number of publications: 236
uniqueness weight: 0.904146
type: Concept

Emeritus
type: Department
type: Organization

Medicine
type: Department
type: Organization

Pediatrics
type: Department
type: Organization

Surgery
type: Department
type: Organization

Systems Biology
type: Department
type: Organization

Hematology/Oncology
type: Division
type: Organization

Cardiology
type: Division
type: Organization

Pulmonary
type: Division
type: Organization

Immunology
type: Division
type: Organization

Hemostasis & Thrombosis
type: Division
type: Organization

Beth Israel Deaconess Medical Center
type: Organization

Brigham and Women's Hospital
type: Organization

Boston Children's Hospital
type: Organization

Harvard Medical School
type: Organization

Kwiatkowski, David
eCommons Login: DJK5
first name: David
last name: Kwiatkowski
full name: David Joseph Kwiatkowski, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.33812600000000
longitude: -71.10492100000000
Person ID: 56716
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Italiano, Joseph
eCommons Login: JEI1
first name: Joseph
last name: Italiano
full name: Joseph E. Italiano, Ph.D.
has faculty rank: Associate Professor
latitude: 42.33812600000000
longitude: -71.10492100000000
Person ID: 64637
person in primary position: James and Thea Stoneman Associate Professor of Surgery in the Field of Vascular Biology
type: Agent
type: Person
preferred title: James and Thea Stoneman Associate Professor of Surgery in the Field of Vascular Biology

Kim, Carla
eCommons Login: CK65
first name: Carla
last name: Kim
full name: Carla Kim, Ph.D.
has faculty rank: Full Professor
latitude: 42.33812600000000
longitude: -71.10492100000000
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Handin, Robert
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Flaumenhaft, Robert
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Michelson, Alan
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Bunn, Howard
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Daley, George
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Geha, Raif
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Osborn, Eric
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Silberstein, Leslie
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Wagner, Denisa
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Frelinger, Andrew
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Authorship 146573
type: Authorship
author rank in publication: 6
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linked information resource: WIP is critical for T cell responsiveness to IL-2.

Authorship 158152
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author rank in publication: 6
linked author: Hartwig, John
linked information resource: Mechanisms of cold-induced platelet actin assembly.

Authorship 151809
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linked information resource: Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B.

Authorship 121405
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

Professor of Medicine
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position in division: Pulmonary
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HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Professor of Medicine
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Authorship 126723
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linked information resource: Cytochalasin B and the structure of actin gels.

Authorship 132762
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linked information resource: Distribution of actin-binding protein and myosin in neutrophils during chemotaxis and phagocytosis.

Authorship 121970
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linked information resource: Distribution of actin, myosin, actin-binding protein and gelsolin in cultured lymphoid cells.

Authorship 122478
type: Authorship
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linked author: Hartwig, John
linked information resource: Mechanisms of organelle transport and capture along proplatelets during platelet production.

Clinical and Academic Affairs
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Authorship 127377
type: Authorship
author rank in publication: 7
linked author: Hartwig, John
linked information resource: Direct dynamin-actin interactions regulate the actin cytoskeleton.

Authorship 179261
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linked information resource: P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo.

Authorship 141956
type: Authorship
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linked information resource: GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.

Authorship 151851
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linked information resource: Polarization of gelsolin and actin binding protein in kidney epithelial cells.

BCMP
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Authorship 139063
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linked author: Hartwig, John
linked information resource: Mechanisms and implications of platelet discoid shape.

Authorship 214522
type: Authorship
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linked information resource: WIP regulates N-WASP-mediated actin polymerization and filopodium formation.

Authorship 147790
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linked information resource: Gelsolin is a downstream effector of rac for fibroblast motility.

Authorship 153059
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linked information resource: How phagocytic leukocytes move.

Authorship 153022
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linked information resource: Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow.

Authorship 223538
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linked information resource: Actin-binding proteins 1: spectrin superfamily.

Authorship 15224
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linked information resource: Vasopressin-induced changes in the three-dimensional structure of toad bladder apical surface.

Authorship 143457
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linked information resource: Cytochalasin B and the structure of actin gels. II. Further evidence for the splitting of F-actin by cytochalasin B.

Authorship 162895
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linked information resource: D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.

Authorship 165487
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linked information resource: Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis.

Authorship 167946
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author rank in publication: 4
linked author: Hartwig, John
linked information resource: Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.

Authorship 183000
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linked author: Hartwig, John
linked information resource: Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis.

Authorship 225526
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linked author: Hartwig, John
linked information resource: Cell surface actin remodeling.

Authorship 20286
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linked information resource: Polyphosphoinositide synthesis and platelet shape change.

Authorship 19945
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linked information resource: Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28.

Authorship 211604
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linked information resource: Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics.

Authorship 233175
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linked information resource: The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets.

Authorship 278494
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linked information resource: FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.

Authorship 292964
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linked author: Hartwig, John
linked information resource: An active biopolymer network controlled by molecular motors.

Authorship 293427
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linked author: Hartwig, John
linked information resource: Dual roles for hepatic lectin receptors in the clearance of chilled platelets.

Authorship 380412
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linked author: Hartwig, John
linked information resource: The filamins: organizers of cell structure and function.

Authorship 210884
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linked information resource: Actin-binding proteins. 1: Spectrin super family.

Authorship 501482
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linked information resource: Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.

Authorship 204703
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linked information resource: FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.

Authorship 347220
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.

Authorship 360178
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Identification of actin-binding protein and villin in toad bladder epithelia.

Authorship 457099
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author rank in publication: 3
linked author: Hartwig, John
linked information resource: The lymphocyte-specific protein LSP1 binds to F-actin and to the cytoskeleton through its COOH-terminal basic domain.

Authorship 57087
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author rank in publication: 2
linked author: Hartwig, John
linked information resource: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.

Authorship 241258
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.

Authorship 305444
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author rank in publication: 2
linked author: Hartwig, John
linked information resource: Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation.

Assistant Professor of Medicine
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position in division: Cardiology
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HR job title: Assistant Professor of Medicine
position in organization: Beth Israel Deaconess Medical Center

Authorship 475209
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author rank in publication: 7
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linked information resource: Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.

Authorship 261164
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linked information resource: WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation.

Authorship 322491
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linked information resource: Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments.

Authorship 345492
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linked information resource: Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.

Authorship 61009
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linked information resource: Filamins in cell signaling, transcription and organ development.

Authorship 641912
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linked information resource: Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.

Authorship 186
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linked information resource: The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association.

Authorship 68642
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.

Hasib Sabbagh Professor of Systems Biology
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Hasib Sabbagh Professor of Systems Biology
position in organization: Harvard Medical School

Authorship 198639
type: Authorship
author rank in publication: 5
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linked information resource: A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets.

Authorship 561237
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes.

Authorship 564477
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Mechanism of shape change in chilled human platelets.

Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-ß1.
PubMed Identifier: 24133214
author list: Kim H, Falet H, Hoffmeister KM, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-ß1. J Biol Chem. 2013 Nov 29; 288(48):34352-63.
journal title abbreviation: J Biol Chem
publication date: 2013-10-16T00:00:00
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type: Article
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type: Information Resource

Authorship 26167
type: Authorship
author rank in publication: 4
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linked information resource: Filamins as integrators of cell mechanics and signalling.

Authorship 274512
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

Paneth cells as a site of origin for intestinal inflammation.
PubMed Identifier: 24089213
author list: Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS
published in: Nature
information resource reference: Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14; 503(7475):272-6.
journal title abbreviation: Nature
publication date: 2013-10-02T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 208219
type: Authorship
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linked information resource: Actin filament architecture and movements in macrophage cytoplasm.

Professor of Pathology, Emeritus
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Professor of Pathology, Emeritus
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Professor of Medicine, Emeritus
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Professor of Medicine, Emeritus
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HR job title: Professor of Medicine, Emeritus
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Professor of Pediatrics and Medicine, Emeritus
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Professor of Pediatrics and Medicine, Emeritus
position in organization: Harvard Medical School

Professor of Medicine, Emeritus
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HR job title: Professor of Medicine, Emeritus
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Authorship 366113
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linked information resource: The cortical actin gel of macrophages.

Authorship 695708
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linked author: Hartwig, John
linked information resource: Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-ß1.

Authorship 251529
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author rank in publication: 4
linked author: Hartwig, John
linked information resource: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines.

Authorship 245163
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linked author: Hartwig, John
linked information resource: The organization and regulation of the macrophage actin skeleton.

Authorship 260591
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope.

Authorship 271087
type: Authorship
author rank in publication: 26
linked author: Hartwig, John
linked information resource: B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

Authorship 73992
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton.

Authorship 76226
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.

Authorship 76930
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.

Authorship 4560
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Lymphocyte-specific protein 1 expression in eukaryotic cells reproduces the morphologic and motile abnormality of NAD 47/89 neutrophils.

Authorship 383454
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Effect of ATP on actin filament stiffness.

Authorship 469685
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: Extracellular DNA traps promote thrombosis.

Authorship 719636
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: Paneth cells as a site of origin for intestinal inflammation.

Authorship 262185
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Interactions of tensin with actin and identification of its three distinct actin-binding domains.

Authorship 27179
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linked author: Hartwig, John
linked information resource: WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.

Authorship 301391
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.

Authorship 16989
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells.

Authorship 227131
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin.

Authorship 231298
type: Authorship
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linked author: Hartwig, John
linked information resource: Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function.

Authorship 35370
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Macrophages: their use in elucidation of the cytoskeletal roles of actin.

Authorship 35622
type: Authorship
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linked author: Hartwig, John
linked information resource: Actin and septin ultrastructures at the budding yeast cell cortex.

Authorship 175327
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Macrophage actin-binding protein.

Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.
PubMed Identifier: 24891099
author list: Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S
published in: Traffic (Copenhagen, Denmark)
information resource reference: Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic. 2014 Aug; 15(8):819-38.
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Authorship 187066
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author rank in publication: 2
linked author: Hartwig, John
linked information resource: Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis.

Authorship 28575
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author rank in publication: 3
linked author: Hartwig, John
linked information resource: Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin.

Authorship 421764
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linked author: Hartwig, John
linked information resource: The gelation of actin by actin-binding protein.

Authorship 435792
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linked author: Hartwig, John
linked information resource: ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.

Authorship 33718
type: Authorship
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linked author: Hartwig, John
linked information resource: The structure of the GPIb-filamin A complex.

Professor of Pediatrics
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position in division: Hematology/Oncology
sort order: 1
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James L. Gamble Professor of Pediatrics
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Director, Career Enhancement for Faculty in Science
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James and Thea Stoneman Associate Professor of Surgery in the Field of Vascular Biology
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
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HR job title: James and Thea Stoneman Associate Professor of Surgery in the Field of Vascular Biology
position in organization: Boston Children's Hospital

Caroline Shields Walker Professor of Medicine
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Caroline Shields Walker Professor of Medicine
position in organization: Harvard Medical School

Corresponding Member of the Faculty of Pediatrics
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Authorship 461221
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linked information resource: Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.

Authorship 394834
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI).

Authorship 479963
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Authorship 747299
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linked information resource: Documentation and localization of force-mediated filamin A domain perturbations in moving cells.

Authorship 751507
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linked information resource: Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity.

Documentation and localization of force-mediated filamin A domain perturbations in moving cells.
PubMed Identifier: 25120197
author list: Nakamura F, Song M, Hartwig JH, Stossel TP
published in: Nature communications
information resource reference: Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014 Aug 14; 5:4656.
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Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
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information resource reference: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 04; 5:4746.
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linked information resource: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Authorship 562340
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linked information resource: Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.

Authorship 420806
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linked information resource: The origin and function of platelet glycosyltransferases.

Authorship 765410
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author rank in publication: 9
linked author: Hartwig, John
linked information resource: Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.

Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.
PubMed Identifier: 25246631
author list: Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS
published in: Molecular and cellular biology
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Authorship 481664
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linked information resource: Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin.

The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
PubMed Identifier: 25485912
author list: Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM
published in: Nature medicine
information resource reference: The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan; 21(1):47-54.
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Authorship 485044
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linked information resource: Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change.

Authorship 486867
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linked information resource: Interpreting photoactivated fluorescence microscopy measurements of steady-state actin dynamics.

Authorship 50264
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linked information resource: Transfusion medicine illustrated. The human blood platelet, resting and active.

Authorship 539581
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linked information resource: Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.

Authorship 551367
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linked information resource: Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex.

Authorship 777308
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linked information resource: The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.

Authorship 56347
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linked information resource: Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.

Authorship 552179
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Authorship 297425
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Authorship 55594
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linked information resource: Determination of GTP loading on Rac and Cdc42 in platelets and fibroblasts.

Authorship 573913
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linked information resource: Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation.

Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
PubMed Identifier: 25744693
author list: Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B
published in: Nature communications
information resource reference: Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2015 Mar 06; 6:6507.
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FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
PubMed Identifier: 25838348
author list: Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H
published in: Blood
information resource reference: FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02; 126(1):80-8.
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Authorship 407421
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Authorship 438217
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Authorship 450465
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Authorship 428156
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Authorship 435986
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Authorship 503723
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Authorship 459278
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Authorship 499789
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Authorship 271243
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Authorship 550014
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Authorship 224636
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Authorship 520151
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linked information resource: MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.

Authorship 186794
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linked information resource: Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments.

Authorship 61314
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linked author: Hartwig, John
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Authorship 465633
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linked information resource: The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages.

Authorship 483705
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Authorship 514090
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linked author: Hartwig, John
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Authorship 296147
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linked author: Hartwig, John
linked information resource: Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.

Authorship 95012
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linked author: Hartwig, John
linked information resource: Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.

Authorship 7048
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linked information resource: Alpha-adducin dissociates from F-actin and spectrin during platelet activation.

Authorship 743
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linked author: Hartwig, John
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Authorship 256951
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Authorship 299200
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linked information resource: Actin filament assembly in permeabilized platelets.

Authorship 308424
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linked author: Hartwig, John
linked information resource: Differential stimulation of monocytic cells results in distinct populations of microparticles.

Authorship 26615
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linked author: Hartwig, John
linked information resource: Actin gelation and structure of cortical cytoplasm.

Authorship 422876
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linked author: Hartwig, John
linked information resource: Actin-binding proteins.

Authorship 289468
type: Authorship
author rank in publication: 10
linked author: Hartwig, John
linked information resource: The clearance mechanism of chilled blood platelets.

Authorship 290109
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author rank in publication: 10
linked author: Hartwig, John
linked information resource: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

Authorship 306843
type: Authorship
author rank in publication: 1
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linked information resource: Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets.

Authorship 279387
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author rank in publication: 5
linked author: Hartwig, John
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Authorship 320392
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linked author: Hartwig, John
linked information resource: Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity.

Authorship 404344
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linked author: Hartwig, John
linked information resource: Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane.

Authorship 411686
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linked author: Hartwig, John
linked information resource: Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation.

Authorship 453689
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linked author: Hartwig, John
linked information resource: Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets.

Authorship 483785
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linked author: Hartwig, John
linked information resource: Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells.

Authorship 50998
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linked author: Hartwig, John
linked information resource: Structural basis of filamin A functions.

Authorship 440482
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linked author: Hartwig, John
linked information resource: SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth.

Authorship 63068
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer.

Authorship 98044
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author rank in publication: 2
linked author: Hartwig, John
linked information resource: Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase.

Authorship 295274
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author rank in publication: 3
linked author: Hartwig, John
linked information resource: Mechanics of proplatelet elaboration.

Authorship 345173
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.

Authorship 352329
type: Authorship
author rank in publication: 7
linked author: Hartwig, John
linked information resource: Microtubule and cortical forces determine platelet size during vascular platelet production.

Authorship 414279
type: Authorship
author rank in publication: 7
linked author: Hartwig, John
linked information resource: Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.

Authorship 431861
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa.

Authorship 23982
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author rank in publication: 7
linked author: Hartwig, John
linked information resource: Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

Authorship 360577
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author rank in publication: 4
linked author: Hartwig, John
linked information resource: Lipid kinases are novel effectors of the GTPase Rac1.

Authorship 400965
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author rank in publication: 3
linked author: Hartwig, John
linked information resource: Stress-dependent elasticity of composite actin networks as a model for cell behavior.

Authorship 487470
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author rank in publication: 1
linked author: Hartwig, John
linked information resource: Mechanisms of actin rearrangements mediating platelet activation.

Authorship 489472
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linked author: Hartwig, John
linked information resource: Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro.

Authorship 572147
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author rank in publication: 2
linked author: Hartwig, John
linked information resource: The structure of the macrophage actin skeleton.

Authorship 573623
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linked author: Hartwig, John
linked information resource: Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.

Authorship 341280
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linked author: Hartwig, John
linked information resource: Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex.

Authorship 346754
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author rank in publication: 4
linked author: Hartwig, John
linked information resource: Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha.

Authorship 429016
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.

Authorship 807261
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.

Authorship 806858
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Authorship 797796
type: Authorship
author rank in publication: 16
linked author: Hartwig, John
linked information resource: Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.
PubMed Identifier: 25411426
author list: Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH
published in: Blood
information resource reference: Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. Blood. 2015 Jan 29; 125(5):860-8.
journal title abbreviation: Blood
publication date: 2014-11-19T00:00:00
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type: Academic Article
type: Article
type: Document
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Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
PubMed Identifier: 26028144
author list: Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG
published in: Nature communications
information resource reference: Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nat Commun. 2015 Jun 01; 6:7254.
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Authorship 67243
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linked author: Hartwig, John
linked information resource: Normal Arp2/3 complex activation in platelets lacking WASp.

Authorship 319062
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author rank in publication: 5
linked author: Hartwig, John
linked information resource: Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets.

Authorship 280493
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin.

Authorship 325001
type: Authorship
author rank in publication: 19
linked author: Hartwig, John
linked information resource: N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

Authorship 444136
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author rank in publication: 4
linked author: Hartwig, John
linked information resource: The small GTPase RalA targets filamin to induce filopodia.

Authorship 519133
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author rank in publication: 5
linked author: Hartwig, John
linked information resource: Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells.

Authorship 370851
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linked author: Hartwig, John
linked information resource: Actin cytoskeleton. Setting the pace of cell movement.

Authorship 37190
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Glycosylation restores survival of chilled blood platelets.

Authorship 389092
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Cytoskeletal mechanisms for platelet production.

Authorship 411966
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Regulation of the actin cycle in vivo by actin filament severing.

Authorship 431911
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein.

Authorship 811375
type: Authorship
author rank in publication: 13
linked author: Hartwig, John
linked information resource: FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

Authorship 482991
type: Authorship
author rank in publication: 5
linked author: Hartwig, John
linked information resource: Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.

Authorship 293586
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linked author: Hartwig, John
linked information resource: Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.

Authorship 298668
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1000146

Authorship 296199
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly.

Authorship 298922
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Gelsolin-independent podosome formation in dendritic cells.

Authorship 444066
type: Authorship
author rank in publication: 7
linked author: Hartwig, John
linked information resource: Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.

Authorship 465292
type: Authorship
author rank in publication: 10
linked author: Hartwig, John
linked information resource: Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.

Authorship 61706
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.

Authorship 417941
type: Authorship
author rank in publication: 3
linked author: Hartwig, John
linked information resource: Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis.

Authorship 438587
type: Authorship
author rank in publication: 10
linked author: Hartwig, John
linked information resource: Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.

Authorship 528391
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: WIP participates in actin reorganization and ruffle formation induced by PDGF.

Authorship 539861
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.

Authorship 480462
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: The motor of leukocytes.

What Is the Role of Filamin 1 in Myeloid Cell Function?
end date: 1999-06-18T00:00:00
start date: 1999-03-01T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time

The Relationship between Mutacin Production and Early Childhood Caries
end date: 2004-08-01T00:00:00
start date: 2004-06-21T00:00:00
type: Mentoring - Completed Student Project
overview: Full Time

Role of Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
end date: 1999-06-30T00:00:00
start date: 1998-07-01T00:00:00
type: Mentoring - Completed Student Project
overview: Full Time/Year Long

The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
end date: 2001-06-01T00:00:00
start date: 2000-09-01T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time/Continuation

Authorship 858448
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu).

An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu).
PubMed Identifier: 26707877
author list: Song M, He Q, Berk BA, Hartwig JH, Stossel TP, Nakamura F
published in: Biochemical and biophysical research communications
information resource reference: An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016 Jan 15; 469(3):659-64.
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publication date: 2015-12-17T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix Complex in the Human Platelet
end date: 2000-08-31T00:00:00
start date: 2000-06-18T00:00:00
type: Mentoring - Completed Student Project
overview: Summer/Continuation

role of teh Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
end date: 2000-06-30T00:00:00
start date: 2000-01-03T00:00:00
type: Mentoring - Completed Student Project
overview: Full Time/Year Long

Authorship 298526
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: The biogenesis of platelets from megakaryocyte proplatelets.

Authorship 307179
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.

Authorship 307921
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Immunoelectron microscopic localization of actin, alpha-actinin, actin-binding protein and myosin in resting and activated human blood platelets.

Outside-In Integration Signaling Accelerates Platelet Action Filament Turnover
end date: 2000-12-31T00:00:00
start date: 2000-09-01T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time/Continuation

Authorship 871771
type: Authorship
author rank in publication: 12
linked author: Hartwig, John
linked information resource: Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.
PubMed Identifier: 26744461
author list: Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE
published in: Blood
information resource reference: Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80.
journal title abbreviation: Blood
publication date: 2016-01-07T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

What is the Role of Filamin 1 in Myeloid Cell Function?
end date: 2000-01-01T00:00:00
start date: 1999-09-01T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time/Continuation

The Relationship Between Filamin B, an Actin-binding Protein isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
end date: 2000-06-15T00:00:00
start date: 2000-01-03T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time

What is the Role of Filamin 1 in Myeloid Cell Function?
end date: 1999-08-31T00:00:00
start date: 1999-06-21T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Impact of Limited English and Physician Language Concordance on Health Care Delivery and Patient Satisfaction
end date: 2004-08-27T00:00:00
start date: 2004-07-05T00:00:00
type: Mentoring - Completed Student Project
overview: Full Time

Role of the Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
end date: 1999-11-30T00:00:00
start date: 1999-09-01T00:00:00
type: Mentoring - Completed Student Project
overview: Full Time

Regulatory T cells in Merkel Cell Carcinoma
end date: 2006-08-25T00:00:00
start date: 2006-06-19T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 76339
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.

Authorship 891146
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia.

Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia.
PubMed Identifier: 27073223
author list: Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH
published in: Blood
information resource reference: Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood. 2016 07 07; 128(1):93-103.
journal title abbreviation: Blood
publication date: 2016-04-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 87470
type: Authorship
author rank in publication: 13
linked author: Hartwig, John
linked information resource: Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.

Authorship 544965
type: Authorship
author rank in publication: 8
linked author: Hartwig, John
linked information resource: Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.

Authorship 84150
type: Authorship
author rank in publication: 8
linked author: Hartwig, John
linked information resource: WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.

Authorship 95919
type: Authorship
author rank in publication: 10
linked author: Hartwig, John
linked information resource: Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Authorship 490079
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Cortical actin structures and their relationship to mammalian cell movements.

Authorship 518194
type: Authorship
author rank in publication: 9
linked author: Hartwig, John
linked information resource: Cytoskeletal mechanics of proplatelet maturation and platelet release.

SIGNALING AND CYTOSKELETAL ORGANIZATION IN BLOOD CELLS
end date: 2014-08-31
principal investigator name: GEHA, RAIF SALIM
start date: 1997-09-30
type: Grant
sponsor award id: P01HL059561

CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
end date: 2013-08-31
principal investigator name: BROWN, DENNIS
start date: 1987-04-01
type: Grant
sponsor award id: P01DK038452

Adhesion Molecules in Transfusion Biology
end date: 2012-07-31
principal investigator name: WAGNER, DENISA D
start date: 1996-09-05
type: Grant
sponsor award id: P01HL056949

MECHANISM OF F ACTIN CROSSLINKING BY ABP
end date: 1989-11-30
principal investigator name: HARTWIG, JOHN H
start date: 1986-12-01
type: Grant
sponsor award id: R01GM036507

Regulation of Platelet Shape Changes
end date: 2009-06-30
principal investigator name: HARTWIG, JOHN H
start date: 1996-04-01
type: Grant
sponsor award id: R01HL056252

Filamin A - Syk Interactions Modulate Platelet ITAM-based Signaling
end date: 2015-05-31
principal investigator name: HARTWIG, JOHN H
start date: 2011-06-15
type: Grant
sponsor award id: R01HL104145

PRESERVING 3-D STRUCTURE USING A BALZERS 400T
end date: 1989-02-28
principal investigator name: HARTWIG, JOHN H
start date: 1988-02-29
type: Grant
sponsor award id: S10RR004209

REGULATION OF PLATELET SHAPE CHANGES
end date: 1995-05-31
principal investigator name: HARTWIG, JOHN H
start date: 1991-06-01
type: Grant
sponsor award id: R01HL047874

Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: Filamin A - Syk Interactions Modulate Platelet ITAM-based Signaling

Co-Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: Adhesion Molecules in Transfusion Biology

Co-Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: SIGNALING AND CYTOSKELETAL ORGANIZATION IN BLOOD CELLS

Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: REGULATION OF PLATELET SHAPE CHANGES

Co-Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE

Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: MECHANISM OF F ACTIN CROSSLINKING BY ABP

Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: PRESERVING 3-D STRUCTURE USING A BALZERS 400T

Principal Investigator
type: Researcher Role
researcher role of: Hartwig, John
contributes to: Regulation of Platelet Shape Changes

Authorship 60404
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils.

Authorship 63809
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The birth of the platelet.

Authorship 71004
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: The mechanics of F-actin microenvironments depend on the chemistry of probing surfaces.

Authorship 331841
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The elegant platelet: signals controlling actin assembly.

Authorship 389288
type: Authorship
author rank in publication: 8
linked author: Hartwig, John
linked information resource: In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration.

Authorship 919857
type: Authorship
author rank in publication: 16
linked author: Hartwig, John
linked information resource: A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Authorship 415179
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: The motor of amoeboid leucocytes.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
PubMed Identifier: 27599296
author list: Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS
published in: The Journal of clinical investigation
information resource reference: A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851.
journal title abbreviation: J Clin Invest
publication date: 2016-09-06T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 931577
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Synthetic chemistry: recipes for excess.

Synthetic chemistry: recipes for excess.
PubMed Identifier: 16177775
author list: Hartwig J
published in: Nature
information resource reference: Synthetic chemistry: recipes for excess. Nature. 2005 Sep 22; 437(7058):487-8.
journal title abbreviation: Nature
publication date: 2005-09-22T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 64083
type: Authorship
author rank in publication: 4
linked author: Hartwig, John
linked information resource: Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor.

Authorship 93088
type: Authorship
author rank in publication: 7
linked author: Hartwig, John
linked information resource: Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.

Authorship 364823
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Measuring actin dynamics in endothelial cells.

Authorship 42114
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons.

Authorship 443651
type: Authorship
author rank in publication: 2
linked author: Hartwig, John
linked information resource: Cell crawling two decades after Abercrombie.

Authorship 455146
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: CLEC-2 activates Syk through dimerization.

Authorship 52616
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The platelet: form and function.

Authorship 559049
type: Authorship
author rank in publication: 6
linked author: Hartwig, John
linked information resource: Activating mutations of N-WASP alter Shigella pathogenesis.

Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants.
PubMed Identifier: 8744952
author list: Cox D, Wessels D, Soll DR, Hartwig J, Condeelis J
published in: Molecular biology of the cell
information resource reference: Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants. Mol Biol Cell. 1996 May; 7(5):803-23.
journal title abbreviation: Mol Biol Cell
publication date: 1996-05-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha.
PubMed Identifier: 9006936
author list: Meyer SC, Zuerbig S, Cunningham CC, Hartwig JH, Bissell T, Gardner K, Fox JE
published in: The Journal of biological chemistry
information resource reference: Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha. J Biol Chem. 1997 Jan 31; 272(5):2914-9.
journal title abbreviation: J Biol Chem
publication date: 1997-01-31T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Lymphocyte-specific protein 1 expression in eukaryotic cells reproduces the morphologic and motile abnormality of NAD 47/89 neutrophils.
PubMed Identifier: 9616178
author list: Howard TH, Hartwig J, Cunningham C
published in: Blood
information resource reference: Lymphocyte-specific protein 1 expression in eukaryotic cells reproduces the morphologic and motile abnormality of NAD 47/89 neutrophils. Blood. 1998 Jun 15; 91(12):4786-95.
journal title abbreviation: Blood
publication date: 1998-06-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 960369
type: Authorship
author rank in publication: 1
linked author: Hartwig, John
linked information resource: The Dynamic Cytoskeleton of the Megakaryocyte.

The Dynamic Cytoskeleton of the Megakaryocyte.
PubMed Identifier: 11544661
author list: Hartwig JH, Barkalov K, Italiano J
published in: Cellular & molecular biology letters
information resource reference: The Dynamic Cytoskeleton of the Megakaryocyte. Cell Mol Biol Lett. 2001; 6(2):208.
journal title abbreviation: Cell Mol Biol Lett
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin filament assembly in permeabilized platelets.
PubMed Identifier: 11036617
author list: Hartwig JH, Barkalow KL
published in: Methods in enzymology
information resource reference: Actin filament assembly in permeabilized platelets. Methods Enzymol. 2000; 325:349-56.
journal title abbreviation: Methods Enzymol
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
PubMed Identifier: 8955143
author list: Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A
published in: The Journal of biological chemistry
information resource reference: D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem. 1996 Dec 20; 271(51):32986-93.
journal title abbreviation: J Biol Chem
publication date: 1996-12-20T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.
PubMed Identifier: 9045671
author list: Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG
published in: The Journal of biological chemistry
information resource reference: The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem. 1997 Mar 07; 272(10):6465-70.
journal title abbreviation: J Biol Chem
publication date: 1997-03-07T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane.
PubMed Identifier: 9060453
author list: Wientjes FB, Segal AW, Hartwig JH
published in: Journal of leukocyte biology
information resource reference: Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane. J Leukoc Biol. 1997 Mar; 61(3):303-12.
journal title abbreviation: J Leukoc Biol
publication date: 1997-03-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.
PubMed Identifier: 19692704
author list: Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH
published in: Blood
information resource reference: Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19; 114(21):4729-37.
journal title abbreviation: Blood
publication date: 2009-08-19T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase).
PubMed Identifier: 12850840
author list: Paul BZ, Kim S, Dangelmaier C, Nagaswami C, Jin J, Hartwig JH, Weisel JW, Daniel JL, Kunapuli SP
published in: Platelets
information resource reference: Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Platelets. 2003 May; 14(3):159-69.
journal title abbreviation: Platelets
publication date: 2003-05-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

One Blackfan Circle
type: Address
address line 1: Brigham & Women's Hospital
address line 2: Karp 6
address line 3: One Blackfan Circle
city: Boston
postal code: 02215
state or province: MA

Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
PubMed Identifier: 15467741
author list: Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V
published in: Oncogene
information resource reference: Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene. 2004 Nov 18; 23(54):8815-25.
journal title abbreviation: Oncogene
publication date: 2004-11-18T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B.
PubMed Identifier: 135766
author list: Hartwig JH, Stossel TP
published in: The Journal of cell biology
information resource reference: Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B. J Cell Biol. 1976 Oct; 71(1):295-303.
journal title abbreviation: J Cell Biol
publication date: 1976-10-01T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex.
PubMed Identifier: 11090061
author list: Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH
published in: Blood
information resource reference: Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01; 96(12):3786-92.
journal title abbreviation: Blood
publication date: 2000-12-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP regulates N-WASP-mediated actin polymerization and filopodium formation.
PubMed Identifier: 11331876
author list: Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N
published in: Nature cell biology
information resource reference: WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91.
journal title abbreviation: Nat Cell Biol
publication date: 2001-05-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

The birth of the platelet.
PubMed Identifier: 12871294
author list: Hartwig J, Italiano J
published in: Journal of thrombosis and haemostasis : JTH
information resource reference: The birth of the platelet. J Thromb Haemost. 2003 Jul; 1(7):1580-6.
journal title abbreviation: J Thromb Haemost
publication date: 2003-07-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI).
PubMed Identifier: 1833070
author list: Ohta Y, Stossel TP, Hartwig JH
published in: Cell
information resource reference: Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI). Cell. 1991 Oct 18; 67(2):275-82.
journal title abbreviation: Cell
publication date: 1991-10-18T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa.
PubMed Identifier: 15344881
author list: Sobocka MB, Sobocki T, Babinska A, Hartwig JH, Li M, Ehrlich YH, Kornecki E
published in: Journal of receptor and signal transduction research
information resource reference: Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa. J Recept Signal Transduct Res. 2004 Feb; 24(1-2):85-105.
journal title abbreviation: J Recept Signal Transduct Res
publication date: 2004-02-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The elegant platelet: signals controlling actin assembly.
PubMed Identifier: 10605729
author list: Hartwig JH, Barkalow K, Azim A, Italiano J
published in: Thrombosis and haemostasis
information resource reference: The elegant platelet: signals controlling actin assembly. Thromb Haemost. 1999 Aug; 82(2):392-8.
journal title abbreviation: Thromb Haemost
publication date: 1999-08-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association.
PubMed Identifier: 11368764
author list: James MF, Manchanda N, Gonzalez-Agosti C, Hartwig JH, Ramesh V
published in: The Biochemical journal
information resource reference: The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J. 2001 Jun 01; 356(Pt 2):377-86.
journal title abbreviation: Biochem J
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.
PubMed Identifier: 11706047
author list: Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP
published in: The Journal of cell biology
information resource reference: Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12; 155(4):511-7.
journal title abbreviation: J Cell Biol
publication date: 2001-11-12T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow.
PubMed Identifier: 9431512
author list: Satcher R, Dewey CF, Hartwig JH
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow. Microcirculation. 1997 Dec; 4(4):439-53.
journal title abbreviation: Microcirculation
publication date: 1997-12-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.
PubMed Identifier: 1991790
author list: Hartwig JH, DeSisto M
published in: The Journal of cell biology
information resource reference: The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments. J Cell Biol. 1991 Feb; 112(3):407-25.
journal title abbreviation: J Cell Biol
publication date: 1991-02-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils.
PubMed Identifier: 10953003
author list: Glogauer M, Hartwig J, Stossel T
published in: The Journal of cell biology
information resource reference: Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol. 2000 Aug 21; 150(4):785-96.
journal title abbreviation: J Cell Biol
publication date: 2000-08-21T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.
PubMed Identifier: 21566095
author list: Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE
published in: Blood
information resource reference: The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52.
journal title abbreviation: Blood
publication date: 2011-05-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis.
PubMed Identifier: 22981933
author list: Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U
published in: Experimental hematology
information resource reference: Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 2013 Jan; 41(1):91-101.e4.
journal title abbreviation: Exp Hematol
publication date: 2012-09-11T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.
PubMed Identifier: 9405671
author list: Ramesh N, Antón IM, Hartwig JH, Geha RS
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14671-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-12-23T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP participates in actin reorganization and ruffle formation induced by PDGF.
PubMed Identifier: 12724353
author list: Antón IM, Saville SP, Byrne MJ, Curcio C, Ramesh N, Hartwig JH, Geha RS
published in: Journal of cell science
information resource reference: WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51.
journal title abbreviation: J Cell Sci
publication date: 2003-04-30T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The platelet: form and function.
PubMed Identifier: 16427392
author list: Hartwig JH
published in: Seminars in hematology
information resource reference: The platelet: form and function. Semin Hematol. 2006 Jan; 43(1 Suppl 1):S94-100.
journal title abbreviation: Semin Hematol
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Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
PubMed Identifier: 9412467
author list: Liu G, Thomas L, Warren RA, Enns CA, Cunningham CC, Hartwig JH, Thomas G
published in: The Journal of cell biology
information resource reference: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997 Dec 29; 139(7):1719-33.
journal title abbreviation: J Cell Biol
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Normal Arp2/3 complex activation in platelets lacking WASp.
PubMed Identifier: 12200375
author list: Falet H, Hoffmeister KM, Neujahr R, Hartwig JH
published in: Blood
information resource reference: Normal Arp2/3 complex activation in platelets lacking WASp. Blood. 2002 Sep 15; 100(6):2113-22.
journal title abbreviation: Blood
publication date: 2002-09-15T00:00:00
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Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
PubMed Identifier: 12464680
author list: Falet H, Hoffmeister KM, Neujahr R, Italiano JE, Stossel TP, Southwick FS, Hartwig JH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16782-7.
journal title abbreviation: Proc Natl Acad Sci U S A
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year: 2002
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SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth.
PubMed Identifier: 18061565
author list: Bai J, Hartwig JH, Perrimon N
published in: Developmental cell
information resource reference: SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007 Dec; 13(6):828-42.
journal title abbreviation: Dev Cell
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year: 2007
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Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets.
PubMed Identifier: 18096766
author list: Wandall HH, Hoffmeister KM, Sørensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ
published in: Blood
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journal title abbreviation: Blood
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The small GTPase RalA targets filamin to induce filopodia.
PubMed Identifier: 10051605
author list: Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2122-8.
journal title abbreviation: Proc Natl Acad Sci U S A
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Cell crawling two decades after Abercrombie.
PubMed Identifier: 10320944
author list: Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ
published in: Biochemical Society symposium
information resource reference: Cell crawling two decades after Abercrombie. Biochem Soc Symp. 1999; 65:267-80.
journal title abbreviation: Biochem Soc Symp
publication date: 1999-01-01T00:00:00
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Activating mutations of N-WASP alter Shigella pathogenesis.
PubMed Identifier: 19379711
author list: Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB
published in: Biochemical and biophysical research communications
information resource reference: Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys Res Commun. 2009 Jul 03; 384(3):284-9.
journal title abbreviation: Biochem Biophys Res Commun
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Actin-binding protein requirement for cortical stability and efficient locomotion.
PubMed Identifier: 1549777
author list: Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR, Stossel TP
published in: Science (New York, N.Y.)
information resource reference: Actin-binding protein requirement for cortical stability and efficient locomotion. Science. 1992 Jan 17; 255(5042):325-7.
journal title abbreviation: Science
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CLEC-2 activates Syk through dimerization.
PubMed Identifier: 20154219
author list: Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP
published in: Blood
information resource reference: CLEC-2 activates Syk through dimerization. Blood. 2010 Apr 08; 115(14):2947-55.
journal title abbreviation: Blood
publication date: 2010-02-12T00:00:00
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Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly.
PubMed Identifier: 11533030
author list: Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA
published in: The Journal of biological chemistry
information resource reference: Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem. 2001 Nov 16; 276(46):43390-9.
journal title abbreviation: J Biol Chem
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Direct dynamin-actin interactions regulate the actin cytoskeleton.
PubMed Identifier: 20935625
author list: Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S
published in: The EMBO journal
information resource reference: Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606.
journal title abbreviation: EMBO J
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The clearance mechanism of chilled blood platelets.
PubMed Identifier: 12526796
author list: Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH
published in: Cell
information resource reference: The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97.
journal title abbreviation: Cell
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Membrane and microfilament organization and vasopressin action in transporting epithelia.
PubMed Identifier: 3333192
author list: Ausiello DA, Hartwig J, Brown D
published in: Society of General Physiologists series
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journal title abbreviation: Soc Gen Physiol Ser
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Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change.
PubMed Identifier: 12788695
author list: Barkalow KL, Falet H, Italiano JE, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH
published in: American journal of physiology. Cell physiology
information resource reference: Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C797-805.
journal title abbreviation: Am J Physiol Cell Physiol
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Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.
PubMed Identifier: 16118321
author list: Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE
published in: Blood
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journal title abbreviation: Blood
publication date: 2005-08-23T00:00:00
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In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration.
PubMed Identifier: 17319824
author list: Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM
published in: Transfusion
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Actin-binding proteins.
PubMed Identifier: 1854489
author list: Hartwig JH, Kwiatkowski DJ
published in: Current opinion in cell biology
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journal title abbreviation: Curr Opin Cell Biol
publication date: 1991-02-01T00:00:00
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Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.
PubMed Identifier: 18230754
author list: Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE
published in: Blood
information resource reference: Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16.
journal title abbreviation: Blood
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The mechanics of F-actin microenvironments depend on the chemistry of probing surfaces.
PubMed Identifier: 11106629
author list: McGrath JL, Hartwig JH, Kuo SC
published in: Biophysical journal
information resource reference: The mechanics of F-actin microenvironments depend on the chemistry of probing surfaces. Biophys J. 2000 Dec; 79(6):3258-66.
journal title abbreviation: Biophys J
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Differential stimulation of monocytic cells results in distinct populations of microparticles.
PubMed Identifier: 19548909
author list: Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD
published in: Journal of thrombosis and haemostasis : JTH
information resource reference: Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun; 7(6):1019-28.
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Immunoelectron microscopic localization of actin, alpha-actinin, actin-binding protein and myosin in resting and activated human blood platelets.
PubMed Identifier: 2744001
author list: Sixma JJ, van den Berg A, Jockusch BM, Hartwig J
published in: European journal of cell biology
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Actin and septin ultrastructures at the budding yeast cell cortex.
PubMed Identifier: 15525671
author list: Rodal AA, Kozubowski L, Goode BL, Drubin DG, Hartwig JH
published in: Molecular biology of the cell
information resource reference: Actin and septin ultrastructures at the budding yeast cell cortex. Mol Biol Cell. 2005 Jan; 16(1):372-84.
journal title abbreviation: Mol Biol Cell
publication date: 2004-11-03T00:00:00
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The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets.
PubMed Identifier: 15741160
author list: Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM
published in: The Journal of biological chemistry
information resource reference: The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem. 2005 May 06; 280(18):18025-32.
journal title abbreviation: J Biol Chem
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Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.
PubMed Identifier: 6281657
author list: Southwick FS, Hartwig JH
published in: Nature
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journal title abbreviation: Nature
publication date: 1982-05-27T00:00:00
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Distribution of actin-binding protein and myosin in neutrophils during chemotaxis and phagocytosis.
PubMed Identifier: 7115550
author list: Valerius NH, Stendahl OI, Hartwig JH, Stossel TP
published in: Advances in experimental medicine and biology
information resource reference: Distribution of actin-binding protein and myosin in neutrophils during chemotaxis and phagocytosis. Adv Exp Med Biol. 1982; 141:19-28.
journal title abbreviation: Adv Exp Med Biol
publication date: 1982-01-01T00:00:00
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Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.
PubMed Identifier: 16176968
author list: Osborn EA, Rabodzey A, Dewey CF, Hartwig JH
published in: American journal of physiology. Cell physiology
information resource reference: Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C444-52.
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Cytochalasin B and the structure of actin gels.
PubMed Identifier: 583431
author list: Hartwig JH, Stossel TP
published in: Journal of molecular biology
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journal title abbreviation: J Mol Biol
publication date: 1979-11-05T00:00:00
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FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
PubMed Identifier: 16862148
author list: Ohta Y, Hartwig JH, Stossel TP
published in: Nature cell biology
information resource reference: FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol. 2006 Aug; 8(8):803-14.
journal title abbreviation: Nat Cell Biol
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Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin.
PubMed Identifier: 17135294
author list: Osborn TM, Dahlgren C, Hartwig JH, Stossel TP
published in: American journal of physiology. Cell physiology
information resource reference: Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1323-30.
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Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis.
PubMed Identifier: 17934346
author list: Battinelli EM, Hartwig JH, Italiano JE
published in: Current opinion in hematology
information resource reference: Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007 Sep; 14(5):419-26.
journal title abbreviation: Curr Opin Hematol
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Dual roles for hepatic lectin receptors in the clearance of chilled platelets.
PubMed Identifier: 19783995
author list: Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM
published in: Nature medicine
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Determination of GTP loading on Rac and Cdc42 in platelets and fibroblasts.
PubMed Identifier: 11036608
author list: Azim AC, Barkalow KL, Hartwig JH
published in: Methods in enzymology
information resource reference: Determination of GTP loading on Rac and Cdc42 in platelets and fibroblasts. Methods Enzymol. 2000; 325:257-63.
journal title abbreviation: Methods Enzymol
publication date: 2000-01-01T00:00:00
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GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.
PubMed Identifier: 18650435
author list: Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A
published in: The Journal of biological chemistry
information resource reference: GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem. 2008 Oct 03; 283(40):27208-19.
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Gelsolin-independent podosome formation in dendritic cells.
PubMed Identifier: 21779330
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published in: PloS one
information resource reference: Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011; 6(7):e21615.
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The organization and regulation of the macrophage actin skeleton.
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published in: Cell motility and the cytoskeleton
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journal title abbreviation: Cell Motil Cytoskeleton
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Actin filament architecture and movements in macrophage cytoplasm.
PubMed Identifier: 3525038
author list: Hartwig JH
published in: Ciba Foundation symposium
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The structure of the GPIb-filamin A complex.
PubMed Identifier: 16293600
author list: Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J
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Identification of actin-binding protein and villin in toad bladder epithelia.
PubMed Identifier: 6421172
author list: Ausiello DA, Corwin HL, Hartwig JH
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Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein.
PubMed Identifier: 6682423
author list: Niederman R, Amrein PC, Hartwig J
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journal title abbreviation: J Cell Biol
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Cytochalasin B and the structure of actin gels. II. Further evidence for the splitting of F-actin by cytochalasin B.
PubMed Identifier: 6894243
author list: Maruyama K, Hartwig JH, Stossel TP
published in: Biochimica et biophysica acta
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P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo.
PubMed Identifier: 10770806
author list: Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, Kehrel B, Hartwig JH, Vestweber D, Wagner DD
published in: The Journal of experimental medicine
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Regulation of the actin cycle in vivo by actin filament severing.
PubMed Identifier: 10823888
author list: McGrath JL, Osborn EA, Tardy YS, Dewey CF, Hartwig JH
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The lymphocyte-specific protein LSP1 binds to F-actin and to the cytoskeleton through its COOH-terminal basic domain.
PubMed Identifier: 1522116
author list: Jongstra-Bilen J, Janmey PA, Hartwig JH, Galea S, Jongstra J
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journal title abbreviation: J Cell Biol
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MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.
PubMed Identifier: 1560845
author list: Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A
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Mechanisms and implications of platelet discoid shape.
PubMed Identifier: 12586623
author list: Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA
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Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells.
PubMed Identifier: 16446458
author list: Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA
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Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.
PubMed Identifier: 18524950
author list: Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X
published in: Proceedings of the National Academy of Sciences of the United States of America
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Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase.
PubMed Identifier: 2889740
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published in: The Journal of cell biology
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journal title abbreviation: J Cell Biol
publication date: 1987-10-01T00:00:00
year: 1987
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Gelsolin is a downstream effector of rac for fibroblast motility.
PubMed Identifier: 9482733
author list: Azuma T, Witke W, Stossel TP, Hartwig JH, Kwiatkowski DJ
published in: The EMBO journal
information resource reference: Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 1998 Mar 02; 17(5):1362-70.
journal title abbreviation: EMBO J
publication date: 1998-03-02T00:00:00
year: 1998
type: Academic Article
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type: Document
type: Information Resource

Measuring actin dynamics in endothelial cells.
PubMed Identifier: 9858336
author list: McGrath JL, Hartwig JH, Tardy Y, Dewey CF
published in: Microscopy research and technique
information resource reference: Measuring actin dynamics in endothelial cells. Microsc Res Tech. 1998 Dec 01; 43(5):385-94.
journal title abbreviation: Microsc Res Tech
publication date: 1998-12-01T00:00:00
year: 1998
type: Academic Article
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type: Information Resource

Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread.
PubMed Identifier: 23083060
author list: Bishai EA, Sidhu GS, Li W, Dhillon J, Bohil AB, Cheney RE, Hartwig JH, Southwick FS
published in: Cellular microbiology
information resource reference: Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread. Cell Microbiol. 2013 Mar; 15(3):353-367.
journal title abbreviation: Cell Microbiol
publication date: 2012-11-13T00:00:00
year: 2012
type: Academic Article
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Nonmuscle actin-binding proteins.
PubMed Identifier: 3030380
author list: Stossel TP, Chaponnier C, Ezzell RM, Hartwig JH, Janmey PA, Kwiatkowski DJ, Lind SE, Smith DB, Southwick FS, Yin HL
published in: Annual review of cell biology
information resource reference: Nonmuscle actin-binding proteins. Annu Rev Cell Biol. 1985; 1:353-402.
journal title abbreviation: Annu Rev Cell Biol
publication date: 1985-01-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Vasopressin-induced changes in the three-dimensional structure of toad bladder apical surface.
PubMed Identifier: 3120594
author list: Hartwig JH, Ausiello DA, Brown D
published in: The American journal of physiology
information resource reference: Vasopressin-induced changes in the three-dimensional structure of toad bladder apical surface. Am J Physiol. 1987 Nov; 253(5 Pt 1):C707-20.
journal title abbreviation: Am J Physiol
publication date: 1987-11-01T00:00:00
year: 1987
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type: Information Resource

Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.
PubMed Identifier: 6270098
author list: Yin HL, Hartwig JH, Maruyama K, Stossel TP
published in: The Journal of biological chemistry
information resource reference: Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization. J Biol Chem. 1981 Sep 25; 256(18):9693-7.
journal title abbreviation: J Biol Chem
publication date: 1981-09-25T00:00:00
year: 1981
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type: Information Resource

Actin gelation and structure of cortical cytoplasm.
PubMed Identifier: 6286216
author list: Stossel TP, Hartwig JH, Yin HL, Zaner KS, Stendahl OI
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Actin gelation and structure of cortical cytoplasm. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 2:569-78.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1982-01-01T00:00:00
year: 1982
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Mechanisms of cold-induced platelet actin assembly.
PubMed Identifier: 11328807
author list: Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 06; 276(27):24751-9.
journal title abbreviation: J Biol Chem
publication date: 2001-04-27T00:00:00
year: 2001
type: Academic Article
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Cytoskeletal mechanisms for platelet production.
PubMed Identifier: 16464622
author list: Hartwig JH, Italiano JE
published in: Blood cells, molecules & diseases
information resource reference: Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):99-103.
journal title abbreviation: Blood Cells Mol Dis
publication date: 2006-02-07T00:00:00
year: 2006
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Effect of ATP on actin filament stiffness.
PubMed Identifier: 2168523
author list: Janmey PA, Hvidt S, Oster GF, Lamb J, Stossel TP, Hartwig JH
published in: Nature
information resource reference: Effect of ATP on actin filament stiffness. Nature. 1990 Sep 06; 347(6288):95-9.
journal title abbreviation: Nature
publication date: 1990-09-06T00:00:00
year: 1990
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An active biopolymer network controlled by molecular motors.
PubMed Identifier: 19667200
author list: Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15192-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2009-08-10T00:00:00
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Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.
PubMed Identifier: 23153535
author list: Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS
published in: Cancer cell
information resource reference: Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13; 22(5):615-30.
journal title abbreviation: Cancer Cell
publication date: 2012-11-13T00:00:00
year: 2012
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Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.
PubMed Identifier: 9006895
author list: Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J
published in: The Journal of biological chemistry
information resource reference: Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31; 272(5):2620-8.
journal title abbreviation: J Biol Chem
publication date: 1997-01-31T00:00:00
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The biogenesis of platelets from megakaryocyte proplatelets.
PubMed Identifier: 16322779
author list: Patel SR, Hartwig JH, Italiano JE
published in: The Journal of clinical investigation
information resource reference: The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005 Dec; 115(12):3348-54.
journal title abbreviation: J Clin Invest
publication date: 2005-12-01T00:00:00
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Lipid kinases are novel effectors of the GTPase Rac1.
PubMed Identifier: 10470380
author list: Carpenter CL, Tolias KF, Van Vugt A, Hartwig J
published in: Advances in enzyme regulation
information resource reference: Lipid kinases are novel effectors of the GTPase Rac1. Adv Enzyme Regul. 1999; 39:299-312.
journal title abbreviation: Adv Enzyme Regul
publication date: 1999-01-01T00:00:00
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Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes.
PubMed Identifier: 10601342
author list: Italiano JE, Lecine P, Shivdasani RA, Hartwig JH
published in: The Journal of cell biology
information resource reference: Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312.
journal title abbreviation: J Cell Biol
publication date: 1999-12-13T00:00:00
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Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.
PubMed Identifier: 7744773
author list: Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem. 1995 May 12; 270(19):11358-66.
journal title abbreviation: J Biol Chem
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Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.
PubMed Identifier: 7876307
author list: Cox D, Ridsdale JA, Condeelis J, Hartwig J
published in: The Journal of cell biology
information resource reference: Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods. J Cell Biol. 1995 Mar; 128(5):819-35.
journal title abbreviation: J Cell Biol
publication date: 1995-03-01T00:00:00
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Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.
PubMed Identifier: 8089176
author list: Hitt AL, Hartwig JH, Luna EJ
published in: The Journal of cell biology
information resource reference: Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium. J Cell Biol. 1994 Sep; 126(6):1433-44.
journal title abbreviation: J Cell Biol
publication date: 1994-09-01T00:00:00
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Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.
PubMed Identifier: 14645152
author list: Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS
published in: International immunology
information resource reference: Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40.
journal title abbreviation: Int Immunol
publication date: 2003-12-01T00:00:00
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Ca2+ and calmodulin regulate the binding of filamin A to actin filaments.
PubMed Identifier: 16030015
author list: Nakamura F, Hartwig JH, Stossel TP, Szymanski PT
published in: The Journal of biological chemistry
information resource reference: Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005 Sep 16; 280(37):32426-33.
journal title abbreviation: J Biol Chem
publication date: 2005-07-18T00:00:00
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Stress-dependent elasticity of composite actin networks as a model for cell behavior.
PubMed Identifier: 16606229
author list: Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA
published in: Physical review letters
information resource reference: Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett. 2006 Mar 03; 96(8):088102.
journal title abbreviation: Phys Rev Lett
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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.
PubMed Identifier: 22302739
author list: Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD
published in: Blood
information resource reference: B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28.
journal title abbreviation: Blood
publication date: 2012-02-01T00:00:00
year: 2012
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Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.
PubMed Identifier: 23372168
author list: Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS
published in: Blood
information resource reference: Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 04; 121(14):2743-52.
journal title abbreviation: Blood
publication date: 2013-01-31T00:00:00
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Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin.
PubMed Identifier: 8663092
author list: Leterrier JF, Käs J, Hartwig J, Vegners R, Janmey PA
published in: The Journal of biological chemistry
information resource reference: Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin. J Biol Chem. 1996 Jun 28; 271(26):15687-94.
journal title abbreviation: J Biol Chem
publication date: 1996-06-28T00:00:00
year: 1996
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Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity.
PubMed Identifier: 17901210
author list: Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-09-27T00:00:00
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Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.
PubMed Identifier: 18188447
author list: Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS
published in: The Journal of clinical investigation
information resource reference: Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest. 2008 Feb; 118(2):812-9.
journal title abbreviation: J Clin Invest
publication date: 2008-02-01T00:00:00
year: 2008
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https://connects.catalyst.harvard.edu/Profiles/profile/950072
PubMed Identifier: 19520807
author list: Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM
published in: Blood
information resource reference: Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood. 2009 Aug 20; 114(8):1645-54.
journal title abbreviation: Blood
publication date: 2009-06-11T00:00:00
year: 2009
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type: Document
type: Information Resource
label: Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.

ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.
PubMed Identifier: 20530287
author list: Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B
published in: Blood
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journal title abbreviation: Blood
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Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.
PubMed Identifier: 2793934
author list: Hartwig JH, Chambers KA, Hopcia KL, Kwiatkowski DJ
published in: The Journal of cell biology
information resource reference: Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation. J Cell Biol. 1989 Oct; 109(4 Pt 1):1571-9.
journal title abbreviation: J Cell Biol
publication date: 1989-10-01T00:00:00
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type: Information Resource

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
PubMed Identifier: 21926999
author list: Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP
published in: Nature
information resource reference: Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 Sep 18; 478(7368):260-3.
journal title abbreviation: Nature
publication date: 2011-09-18T00:00:00
year: 2011
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Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice.
PubMed Identifier: 22101895
author list: Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM
published in: Blood
information resource reference: Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73.
journal title abbreviation: Blood
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Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury.
PubMed Identifier: 22228373
author list: Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM
published in: American journal of hematology
information resource reference: Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. Am J Hematol. 2012 Feb; 87(2):161-6.
journal title abbreviation: Am J Hematol
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Distribution of actin, myosin, actin-binding protein and gelsolin in cultured lymphoid cells.
PubMed Identifier: 6288420
author list: Thorstensson R, Utter G, Norberg R, Fagraeus A, Hartwig JH, Yin HL, Stossel TP
published in: Experimental cell research
information resource reference: Distribution of actin, myosin, actin-binding protein and gelsolin in cultured lymphoid cells. Exp Cell Res. 1982 Aug; 140(2):395-400.
journal title abbreviation: Exp Cell Res
publication date: 1982-08-01T00:00:00
year: 1982
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type: Information Resource

Isolation of actin-binding protein and villin from toad oocytes.
PubMed Identifier: 6413278
author list: Corwin HL, Hartwig JH
published in: Developmental biology
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journal title abbreviation: Dev Biol
publication date: 1983-09-01T00:00:00
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Actin-binding proteins. 1: Spectrin super family.
PubMed Identifier: 7584474
author list: Hartwig JH
published in: Protein profile
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journal title abbreviation: Protein Profile
publication date: 1995-01-01T00:00:00
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Cytoskeletal mechanics of proplatelet maturation and platelet release.
PubMed Identifier: 21079248
author list: Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE
published in: The Journal of cell biology
information resource reference: Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74.
journal title abbreviation: J Cell Biol
publication date: 2010-11-15T00:00:00
year: 2010
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Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.
PubMed Identifier: 20351098
author list: Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F
published in: The Journal of biological chemistry
information resource reference: Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010 May 28; 285(22):17156-65.
journal title abbreviation: J Biol Chem
publication date: 2010-03-29T00:00:00
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The filamins: organizers of cell structure and function.
PubMed Identifier: 21169733
author list: Nakamura F, Stossel TP, Hartwig JH
published in: Cell adhesion & migration
information resource reference: The filamins: organizers of cell structure and function. Cell Adh Migr. 2011 Mar-Apr; 5(2):160-9.
journal title abbreviation: Cell Adh Migr
publication date: 2011-03-01T00:00:00
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Polyphosphoinositide synthesis and platelet shape change.
PubMed Identifier: 9288469
author list: Hartwig JH, Barkalow K
published in: Current opinion in hematology
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journal title abbreviation: Curr Opin Hematol
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Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages.
PubMed Identifier: 124734
author list: Hartwig JH, Stossel TP
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
publication date: 1975-07-25T00:00:00
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Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex.
PubMed Identifier: 1322701
author list: Katakami Y, Katakami N, Janmey PA, Hartwig JH, Stossel TP
published in: Biochimica et biophysica acta
information resource reference: Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. Biochim Biophys Acta. 1992 Jul 31; 1122(2):123-35.
journal title abbreviation: Biochim Biophys Acta
publication date: 1992-07-31T00:00:00
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Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines.
PubMed Identifier: 9930654
author list: Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ
published in: European journal of cell biology
information resource reference: Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Eur J Cell Biol. 1998 Dec; 77(4):294-302.
journal title abbreviation: Eur J Cell Biol
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Mechanisms of actin rearrangements mediating platelet activation.
PubMed Identifier: 1325975
author list: Hartwig JH
published in: The Journal of cell biology
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journal title abbreviation: J Cell Biol
publication date: 1992-09-01T00:00:00
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Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor.
PubMed Identifier: 10648409
author list: Azim AC, Barkalow K, Chou J, Hartwig JH
published in: Blood
information resource reference: Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood. 2000 Feb 01; 95(3):959-64.
journal title abbreviation: Blood
publication date: 2000-02-01T00:00:00
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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
PubMed Identifier: 11584271
author list: Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW
published in: Nature cell biology
information resource reference: N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904.
journal title abbreviation: Nat Cell Biol
publication date: 2001-10-01T00:00:00
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Glycosylation restores survival of chilled blood platelets.
PubMed Identifier: 12970565
author list: Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP
published in: Science (New York, N.Y.)
information resource reference: Glycosylation restores survival of chilled blood platelets. Science. 2003 Sep 12; 301(5639):1531-4.
journal title abbreviation: Science
publication date: 2003-09-12T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.
PubMed Identifier: 14757742
author list: Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS
published in: The Journal of experimental medicine
information resource reference: WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02; 199(3):357-68.
journal title abbreviation: J Exp Med
publication date: 2004-02-02T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.
PubMed Identifier: 3138234
author list: Ezzell RM, Kenney DM, Egan S, Stossel TP, Hartwig JH
published in: The Journal of biological chemistry
information resource reference: Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets. J Biol Chem. 1988 Sep 15; 263(26):13303-9.
journal title abbreviation: J Biol Chem
publication date: 1988-09-15T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

The cortical actin gel of macrophages.
PubMed Identifier: 3077540
author list: Hartwig JH, Zaner KS, Janmey PA
published in: Society of General Physiologists series
information resource reference: The cortical actin gel of macrophages. Soc Gen Physiol Ser. 1988; 43:125-40.
journal title abbreviation: Soc Gen Physiol Ser
publication date: 1988-01-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.
PubMed Identifier: 9381982
author list: Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH
published in: Advances in enzyme regulation
information resource reference: Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases. Adv Enzyme Regul. 1997; 37:377-90.
journal title abbreviation: Adv Enzyme Regul
publication date: 1997-01-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Isolation and some structural and functional properties of macrophage tropomyosin.
PubMed Identifier: 6838847
author list: Fattoum A, Hartwig JH, Stossel TP
published in: Biochemistry
information resource reference: Isolation and some structural and functional properties of macrophage tropomyosin. Biochemistry. 1983 Mar 01; 22(5):1187-93.
journal title abbreviation: Biochemistry
publication date: 1983-03-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation.
PubMed Identifier: 925089
author list: Hartwig JH, Davies WA, Stossel TP
published in: The Journal of cell biology
information resource reference: Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation. J Cell Biol. 1977 Dec; 75(3):956-67.
journal title abbreviation: J Cell Biol
publication date: 1977-12-01T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource