Keskin, Derin
eCommons Login: DBK10
first name: Derin
last name: Keskin
coauthor of: Wu, Catherine
coauthor of: Reinherz, Ellis
coauthor of: Hacohen, Nir
coauthor of: Ott, Patrick
coauthor of: Neuberg, Donna
full name: Derin Benerci Keskin, Ph.D.
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Person ID: 82351
person in primary position: Research Associate in Medicine
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similar to: Wu, Catherine
similar to: Choueiri, Toni
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Authorship 1050628
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.

Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma.
PubMed Identifier: 29542692
author list: Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ
published in: Nature
information resource reference: Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402.
journal title abbreviation: Nature
publication date: 2018-03-14T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.
PubMed Identifier: 29656892
author list: Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ
published in: Cell
information resource reference: Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. 2018 04 19; 173(3):624-633.e8.
journal title abbreviation: Cell
publication date: 2018-04-12T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1058308
type: Authorship
author rank in publication: 10
linked author: Keskin, Derin
linked information resource: Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously.
PubMed Identifier: 21069937
author list: Zakka LR, Keskin DB, Reche P, Ahmed AR
published in: Clinical and experimental immunology
information resource reference: Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously. Clin Exp Immunol. 2010 Nov; 162(2):224-36.
journal title abbreviation: Clin Exp Immunol
publication date: 2010-11-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Copolymer effects on microglia and T cells in the central nervous system of humanized mice.
PubMed Identifier: 16259003
author list: Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, Santambrogio L, Kuchroo VK, Strominger JL
published in: European journal of immunology
information resource reference: Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005 Dec; 35(12):3683-93.
journal title abbreviation: Eur J Immunol
publication date: 2005-12-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid.
PubMed Identifier: 20923942
author list: Mabrouk D, Gürcan HM, Keskin DB, Christen WG, Ahmed AR
published in: The Annals of pharmacotherapy
information resource reference: Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid. Ann Pharmacother. 2010 Nov; 44(11):1770-6.
journal title abbreviation: Ann Pharmacother
publication date: 2010-10-05T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.
PubMed Identifier: 22373288
author list: DeLuca DS, Keskin DB, Zhang GL, Reinherz EL, Brusic V
published in: BMC bioinformatics
information resource reference: PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments. BMC Bioinformatics. 2011; 12 Suppl 13:S6.
journal title abbreviation: BMC Bioinformatics
publication date: 2011-11-30T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Developmental bias in cleavage-stage mouse blastomeres.
PubMed Identifier: 23177476
author list: Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K
published in: Current biology : CB
information resource reference: Developmental bias in cleavage-stage mouse blastomeres. Curr Biol. 2013 Jan 07; 23(1):21-31.
journal title abbreviation: Curr Biol
publication date: 2012-11-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products.
PubMed Identifier: 20346419
author list: Gürcan HM, Keskin DB, Ahmed AR
published in: Autoimmunity reviews
information resource reference: Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products. Autoimmun Rev. 2010 Jun; 9(8):553-9.
journal title abbreviation: Autoimmun Rev
publication date: 2010-03-24T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Xia, Ning
eCommons Login: NX7
first name: Ning
last name: Xia
full name: Ning Xia, M.D., Ph.D.
has faculty rank: Instructor
Person ID: 170624
person in primary position: Instructor in Neurology
type: Agent
type: Person
preferred title: Instructor in Neurology

Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.
PubMed Identifier: 11937528
author list: Mellor AL, Keskin DB, Johnson T, Chandler P, Munn DH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol. 2002 Apr 15; 168(8):3771-6.
journal title abbreviation: J Immunol
publication date: 2002-04-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Bioinformatic identification and characterization of human endothelial cell-restricted genes.
PubMed Identifier: 20509943
author list: Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P
published in: BMC genomics
information resource reference: Bioinformatic identification and characterization of human endothelial cell-restricted genes. BMC Genomics. 2010 May 28; 11:342.
journal title abbreviation: BMC Genomics
publication date: 2010-05-28T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy.
PubMed Identifier: 18289869
author list: Keskin DB, Stern JN, Fridkis-Hareli M, Razzaque Ahmed A
published in: Cytokine
information resource reference: Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine. 2008 Mar; 41(3):315-21.
journal title abbreviation: Cytokine
publication date: 2008-03-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/1077059
PubMed Identifier: 18648750
author list: Stern JN, Keskin DB, Romero V, Zuniga J, Encinales L, Li C, Awad C, Yunis EJ
published in: Immunologic research
information resource reference: Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report. Immunol Res. 2009; 45(1):1-12.
journal title abbreviation: Immunol Res
publication date: 2009-01-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report.

Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis.
PubMed Identifier: 18726192
author list: Stern JN, Keskin DB
published in: Cellular & molecular biology letters
information resource reference: Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis. Cell Mol Biol Lett. 2008; 13(4):656-66.
journal title abbreviation: Cell Mol Biol Lett
publication date: 2008-08-23T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.
PubMed Identifier: 22912393
author list: Cai A, Keskin DB, DeLuca DS, Alonso A, Zhang W, Zhang GL, Hammond NN, Nardi V, Stone RM, Neuberg D, Sidney J, Brusic V, Wu CJ
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients. Clin Cancer Res. 2012 Oct 15; 18(20):5761-72.
journal title abbreviation: Clin Cancer Res
publication date: 2012-08-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

A review of the current use of rituximab in autoimmune diseases.
PubMed Identifier: 19000786
author list: Gürcan HM, Keskin DB, Stern JN, Nitzberg MA, Shekhani H, Ahmed AR
published in: International immunopharmacology
information resource reference: A review of the current use of rituximab in autoimmune diseases. Int Immunopharmacol. 2009 Jan; 9(1):10-25.
journal title abbreviation: Int Immunopharmacol
publication date: 2008-11-08T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting DEC-205-DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis.
PubMed Identifier: 30134798
author list: Tabansky I, Keskin DB, Watts D, Petzold C, Funaro M, Sands W, Wright P, Yunis EJ, Najjar S, Diamond B, Cao Y, Mooney D, Kretschmer K, Stern JNH
published in: Molecular medicine (Cambridge, Mass.)
information resource reference: Targeting DEC-205-DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis. Mol Med. 2018 05 03; 24(1):17.
journal title abbreviation: Mol Med
publication date: 2018-05-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.
PubMed Identifier: 21345488
author list: Zhang Z, Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T
published in: Biomaterials
information resource reference: Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Biomaterials. 2011 May; 32(14):3666-78.
journal title abbreviation: Biomaterials
publication date: 2011-02-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens.
PubMed Identifier: 30150207
author list: Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ
published in: Blood
information resource reference: A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood. 2018 11 01; 132(18):1911-1921.
journal title abbreviation: Blood
publication date: 2018-08-27T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.
PubMed Identifier: 18362339
author list: Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5172-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-03-24T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.
PubMed Identifier: 21130094
author list: Zhang GL, DeLuca DS, Keskin DB, Chitkushev L, Zlateva T, Lund O, Reinherz EL, Brusic V
published in: Journal of immunological methods
information resource reference: MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles. J Immunol Methods. 2011 Nov 30; 374(1-2):53-61.
journal title abbreviation: J Immunol Methods
publication date: 2010-12-02T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.
PubMed Identifier: 18832707
author list: Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J Immunol. 2008 Oct 15; 181(8):5501-9.
journal title abbreviation: J Immunol
publication date: 2008-10-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens.
PubMed Identifier: 22566864
author list: Keskin DB, Reinhold B, Lee SY, Zhang G, Lank S, O'Connor DH, Berkowitz RS, Brusic V, Kim SJ, Reinherz EL
published in: Frontiers in immunology
information resource reference: Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens. Front Immunol. 2011; 2:75.
journal title abbreviation: Front Immunol
publication date: 2011-12-13T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Acquired mechanisms of immune escape in cancer following immunotherapy.
PubMed Identifier: 30466478
author list: Iorgulescu JB, Braun D, Oliveira G, Keskin DB, Wu CJ
published in: Genome medicine
information resource reference: Acquired mechanisms of immune escape in cancer following immunotherapy. Genome Med. 2018 11 22; 10(1):87.
journal title abbreviation: Genome Med
publication date: 2018-11-22T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
PubMed Identifier: 12228717
author list: Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, Marshall B, Chandler P, Antonia SJ, Burgess R, Slingluff CL, Mellor AL
published in: Science (New York, N.Y.)
information resource reference: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science. 2002 Sep 13; 297(5588):1867-70.
journal title abbreviation: Science
publication date: 2002-09-13T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.
PubMed Identifier: 20615877
author list: Riemer AB, Keskin DB, Zhang G, Handley M, Anderson KS, Brusic V, Reinhold B, Reinherz EL
published in: The Journal of biological chemistry
information resource reference: A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers. J Biol Chem. 2010 Sep 17; 285(38):29608-22.
journal title abbreviation: J Biol Chem
publication date: 2010-07-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.
PubMed Identifier: 30568305
author list: Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA
published in: Nature
information resource reference: Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239.
journal title abbreviation: Nature
publication date: 2018-12-19T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 125967
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.

Peptides
MeSH DescriptorUI: D010455
MeSH semantic group name: Chemicals & Drugs
number of authors: 1619
number of publications: 4354
uniqueness weight: 0.422854
type: Concept

Cancer Vaccines
MeSH DescriptorUI: D019496
MeSH semantic group name: Chemicals & Drugs
number of authors: 431
number of publications: 1160
uniqueness weight: 0.545097
type: Concept

Histocompatibility Antigens Class I
MeSH DescriptorUI: D015395
MeSH semantic group name: Chemicals & Drugs
number of authors: 572
number of publications: 1395
uniqueness weight: 0.607542
type: Concept

Antigens, Neoplasm
MeSH DescriptorUI: D000951
MeSH semantic group name: Chemicals & Drugs
number of authors: 846
number of publications: 2124
uniqueness weight: 0.538088
type: Concept

Epitopes
MeSH DescriptorUI: D000939
MeSH semantic group name: Chemicals & Drugs
MeSH semantic group name: Phenomena
number of authors: 861
number of publications: 2544
uniqueness weight: 0.611536
type: Concept

Biostatistics
type: Department
type: Organization

Medicine
type: Department
type: Organization

Neurology
type: Department
type: Organization

Rheumatology
type: Division
type: Organization

Adult Oncology
type: Division
type: Organization

Oncology
type: Division
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Dana-Farber Cancer Institute
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Choudhury, Atish
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RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis.
PubMed Identifier: 31341290
author list: Li S, Sun J, Allesøe R, Datta K, Bao Y, Oliveira G, Forman J, Jin R, Olsen LR, Keskin DB, Shukla SA, Wu CJ, Livak KJ
published in: Nature protocols
information resource reference: RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis. Nat Protoc. 2019 08; 14(8):2571-2594.
journal title abbreviation: Nat Protoc
publication date: 2019-07-24T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.
PubMed Identifier: 31543463
author list: Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ
published in: Cancer cell
information resource reference: Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019 10 14; 36(4):369-384.e13.
journal title abbreviation: Cancer Cell
publication date: 2019-09-19T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
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Authorship 160503
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author rank in publication: 9
linked author: Keskin, Derin
linked information resource: Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.

A large peptidome dataset improves HLA class I epitope prediction across most of the human population.
PubMed Identifier: 31844290
author list: Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justesen S, Stevens J, Lane WJ, Eisenhaure T, Lan Zhang G, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB
published in: Nature biotechnology
information resource reference: A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 2020 02; 38(2):199-209.
journal title abbreviation: Nat Biotechnol
publication date: 2019-12-16T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
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Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy.
PubMed Identifier: 31959774
author list: Truex NL, Holden RL, Wang BY, Chen PG, Hanna S, Hu Z, Shetty K, Olive O, Neuberg D, Hacohen N, Keskin DB, Ott PA, Wu CJ, Pentelute BL
published in: Scientific reports
information resource reference: Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy. Sci Rep. 2020 01 20; 10(1):723.
journal title abbreviation: Sci Rep
publication date: 2020-01-20T00:00:00
year: 2020
type: Academic Article
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type: Information Resource

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.
PubMed Identifier: 32938797
author list: Bachireddy P, Ennis C, Nguyen VN, Gohil SH, Clement K, Shukla SA, Forman J, Barkas N, Freeman S, Bavli N, Elagina L, Leshchiner I, Mohammad AW, Mathewson ND, Keskin DB, Rassenti LZ, Kipps TJ, Brown JR, Getz G, Ho VT, Gnirke A, Neuberg D, Soiffer RJ, Ritz J, Alyea EP, Kharchenko PV, Wu CJ
published in: Science translational medicine
information resource reference: Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect. Sci Transl Med. 2020 09 16; 12(561).
journal title abbreviation: Sci Transl Med
publication date: 2020-09-16T00:00:00
year: 2020
type: Academic Article
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Authorship 134669
type: Authorship
author rank in publication: 7
linked author: Keskin, Derin
linked information resource: Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells.

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs.
PubMed Identifier: 33024965
author list: Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Bauer MR, Taylor HB, Conway HL, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Keskin DB, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC
published in: bioRxiv : the preprint server for biology
information resource reference: SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs. bioRxiv. 2020 Oct 26.
journal title abbreviation: bioRxiv
publication date: 2020-10-26T00:00:00
year: 2020
type: Academic Article
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Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy.
PubMed Identifier: 33277626
author list: Gohil SH, Iorgulescu JB, Braun DA, Keskin DB, Livak KJ
published in: Nature reviews. Clinical oncology
information resource reference: Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy. Nat Rev Clin Oncol. 2021 04; 18(4):244-256.
journal title abbreviation: Nat Rev Clin Oncol
publication date: 2020-12-04T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Steroid-Peptide Immunoconjugates for Attenuating T Cell Responses in an Experimental Autoimmune Encephalomyelitis Murine Model of Multiple Sclerosis.
PubMed Identifier: 33284575
author list: Sands RW, Tabansky I, Verbeke CS, Keskin D, Michel S, Stern J, Mooney DJ
published in: Bioconjugate chemistry
information resource reference: Steroid-Peptide Immunoconjugates for Attenuating T Cell Responses in an Experimental Autoimmune Encephalomyelitis Murine Model of Multiple Sclerosis. Bioconjug Chem. 2020 12 16; 31(12):2779-2788.
journal title abbreviation: Bioconjug Chem
publication date: 2020-12-07T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.
PubMed Identifier: 33479501
author list: Hu Z, Leet DE, Allesøe RL, Oliveira G, Li S, Luoma AM, Liu J, Forman J, Huang T, Iorgulescu JB, Holden R, Sarkizova S, Gohil SH, Redd RA, Sun J, Elagina L, Giobbie-Hurder A, Zhang W, Peter L, Ciantra Z, Rodig S, Olive O, Shetty K, Pyrdol J, Uduman M, Lee PC, Bachireddy P, Buchbinder EI, Yoon CH, Neuberg D, Pentelute BL, Hacohen N, Livak KJ, Shukla SA, Olsen LR, Barouch DH, Wucherpfennig KW, Fritsch EF, Keskin DB, Wu CJ, Ott PA
published in: Nature medicine
information resource reference: Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 03; 27(3):515-525.
journal title abbreviation: Nat Med
publication date: 2021-01-21T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
PubMed Identifier: 33711273
author list: Braun DA, Street K, Burke KP, Cookmeyer DL, Denize T, Pedersen CB, Gohil SH, Schindler N, Pomerance L, Hirsch L, Bakouny Z, Hou Y, Forman J, Huang T, Li S, Cui A, Keskin DB, Steinharter J, Bouchard G, Sun M, Pimenta EM, Xu W, Mahoney KM, McGregor BA, Hirsch MS, Chang SL, Livak KJ, McDermott DF, Shukla SA, Olsen LR, Signoretti S, Sharpe AH, Irizarry RA, Choueiri TK, Wu CJ
published in: Cancer cell
information resource reference: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma. Cancer Cell. 2021 05 10; 39(5):632-648.e8.
journal title abbreviation: Cancer Cell
publication date: 2021-03-11T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs.
PubMed Identifier: 34171305
author list: Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Gallagher KME, Bauer MR, Taylor HB, Dunn WA, Tarr C, Sidney J, Rachimi S, Conway HL, Katsis K, Wang Y, Leistritz-Edwards D, Durkin MR, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Carulli IP, Chea VA, Chandrashekar A, Bozkus CC, Carrington M, Bhardwaj N, Barouch DH, Sette A, Maus MV, Rice CM, Clauser KR, Keskin DB, Pregibon DC, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC
published in: Cell
information resource reference: Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs. Cell. 2021 07 22; 184(15):3962-3980.e17.
journal title abbreviation: Cell
publication date: 2021-06-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.
PubMed Identifier: 34290406
author list: Oliveira G, Stromhaug K, Klaeger S, Kula T, Frederick DT, Le PM, Forman J, Huang T, Li S, Zhang W, Xu Q, Cieri N, Clauser KR, Shukla SA, Neuberg D, Justesen S, MacBeath G, Carr SA, Fritsch EF, Hacohen N, Sade-Feldman M, Livak KJ, Boland GM, Ott PA, Keskin DB, Wu CJ
published in: Nature
information resource reference: Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma. Nature. 2021 08; 596(7870):119-125.
journal title abbreviation: Nature
publication date: 2021-07-21T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.
PubMed Identifier: 34391888
author list: Klaeger S, Apffel A, Clauser KR, Sarkizova S, Oliveira G, Rachimi S, Le PM, Tarren A, Chea V, Abelin JG, Braun DA, Ott PA, Keshishian H, Hacohen N, Keskin DB, Wu CJ, Carr SA
published in: Molecular & cellular proteomics : MCP
information resource reference: Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples. Mol Cell Proteomics. 2021; 20:100133.
journal title abbreviation: Mol Cell Proteomics
publication date: 2021-08-12T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.
PubMed Identifier: 34663921
author list: Ouspenskaia T, Law T, Clauser KR, Klaeger S, Sarkizova S, Aguet F, Li B, Christian E, Knisbacher BA, Le PM, Hartigan CR, Keshishian H, Apffel A, Oliveira G, Zhang W, Chen S, Chow YT, Ji Z, Jungreis I, Shukla SA, Justesen S, Bachireddy P, Kellis M, Getz G, Hacohen N, Keskin DB, Carr SA, Wu CJ, Regev A
published in: Nature biotechnology
information resource reference: Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. Nat Biotechnol. 2022 02; 40(2):209-217.
journal title abbreviation: Nat Biotechnol
publication date: 2021-10-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy.
PubMed Identifier: 34758319
author list: Bachireddy P, Azizi E, Burdziak C, Nguyen VN, Ennis CS, Maurer K, Park CY, Choo ZN, Li S, Gohil SH, Ruthen NG, Ge Z, Keskin DB, Cieri N, Livak KJ, Kim HT, Neuberg DS, Soiffer RJ, Ritz J, Alyea EP, Pe'er D, Wu CJ
published in: Cell reports
information resource reference: Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2021 11 09; 37(6):109992.
journal title abbreviation: Cell Rep
publication date: 2021-11-09T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Research Associate in Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
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position in organization: Dana-Farber Cancer Institute

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.
PubMed Identifier: 35508657
author list: Oliveira G, Stromhaug K, Cieri N, Iorgulescu JB, Klaeger S, Wolff JO, Rachimi S, Chea V, Krause K, Freeman SS, Zhang W, Li S, Braun DA, Neuberg D, Carr SA, Livak KJ, Frederick DT, Fritsch EF, Wind-Rotolo M, Hacohen N, Sade-Feldman M, Yoon CH, Keskin DB, Ott PA, Rodig SJ, Boland GM, Wu CJ
published in: Nature
information resource reference: Landscape of helper and regulatory antitumour CD4+ T cells in melanoma. Nature. 2022 05; 605(7910):532-538.
journal title abbreviation: Nature
publication date: 2022-05-04T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer.
PubMed Identifier: 35443043
author list: Liu M, Tayob N, Penter L, Sellars M, Tarren A, Chea V, Carulli I, Huang T, Li S, Cheng SC, Le P, Frackiewicz L, Fasse J, Qi C, Liu JF, Stover EH, Curtis J, Livak KJ, Neuberg D, Zhang G, Matulonis UA, Wu CJ, Keskin DB, Konstantinopoulos PA
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer. Clin Cancer Res. 2022 08 02; 28(15):3356-3366.
journal title abbreviation: Clin Cancer Res
publication date: 2022-08-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma.
PubMed Identifier: 35775490
author list: Lee PC, Klaeger S, Le PM, Korthauer K, Cheng J, Ananthapadmanabhan V, Frost TC, Stevens JD, Wong AY, Iorgulescu JB, Tarren AY, Chea VA, Carulli IP, Lemvigh CK, Pedersen CB, Gartin AK, Sarkizova S, Wright KT, Li LW, Nomburg J, Li S, Huang T, Liu X, Pomerance L, Doherty LM, Apffel AM, Wallace LJ, Rachimi S, Felt KD, Wolff JO, Witten E, Zhang W, Neuberg D, Lane WJ, Zhang G, Olsen LR, Thakuria M, Rodig SJ, Clauser KR, Starrett GJ, Doench JG, Buhrlage SJ, Carr SA, DeCaprio JA, Wu CJ, Keskin DB
published in: The Journal of clinical investigation
information resource reference: Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma. J Clin Invest. 2022 07 01; 132(13).
journal title abbreviation: J Clin Invest
publication date: 2022-07-01T00:00:00
year: 2022
type: Academic Article
type: Article
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Authorship 404820
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author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously.

Authorship 1491413
type: Authorship
author rank in publication: 26
linked author: Keskin, Derin
linked information resource: Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.

Authorship 1485578
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Acquired mechanisms of immune escape in cancer following immunotherapy.

Authorship 1494426
type: Authorship
author rank in publication: 17
linked author: Keskin, Derin
linked information resource: Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.

Authorship 1485764
type: Authorship
author rank in publication: 15
linked author: Keskin, Derin
linked information resource: Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.

Authorship 1487242
type: Authorship
author rank in publication: 46
linked author: Keskin, Derin
linked information resource: Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma.

Authorship 1478795
type: Authorship
author rank in publication: 14
linked author: Keskin, Derin
linked information resource: SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs.

Authorship 1487275
type: Authorship
author rank in publication: 23
linked author: Keskin, Derin
linked information resource: Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.

Authorship 1492796
type: Authorship
author rank in publication: 25
linked author: Keskin, Derin
linked information resource: Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders.

Authorship 1487439
type: Authorship
author rank in publication: 26
linked author: Keskin, Derin
linked information resource: Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.

Authorship 1485329
type: Authorship
author rank in publication: 11
linked author: Keskin, Derin
linked information resource: Automated Flow Synthesis of Tumor Neoantigen Peptides for Personalized Immunotherapy.

Authorship 1492326
type: Authorship
author rank in publication: 39
linked author: Keskin, Derin
linked information resource: Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.

Authorship 1479525
type: Authorship
author rank in publication: 13
linked author: Keskin, Derin
linked information resource: Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy.

Authorship 1493665
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linked author: Keskin, Derin
linked information resource: Targeting DEC-205-DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis.

Authorship 1496259
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linked information resource: Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.

Authorship 1483878
type: Authorship
author rank in publication: 24
linked author: Keskin, Derin
linked information resource: A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens.

Authorship 1478570
type: Authorship
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linked author: Keskin, Derin
linked information resource: RNase H-dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis.

Authorship 1489528
type: Authorship
author rank in publication: 15
linked author: Keskin, Derin
linked information resource: Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.

Authorship 1495308
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes.

Authorship 1494842
type: Authorship
author rank in publication: 25
linked author: Keskin, Derin
linked information resource: A large peptidome dataset improves HLA class I epitope prediction across most of the human population.

Authorship 1482322
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy.

Authorship 1486599
type: Authorship
author rank in publication: 23
linked author: Keskin, Derin
linked information resource: Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer.

Authorship 1485808
type: Authorship
author rank in publication: 25
linked author: Keskin, Derin
linked information resource: Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.

Authorship 1485833
type: Authorship
author rank in publication: 35
linked author: Keskin, Derin
linked information resource: Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs.

Authorship 1492338
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Steroid-Peptide Immunoconjugates for Attenuating T Cell Responses in an Experimental Autoimmune Encephalomyelitis Murine Model of Multiple Sclerosis.

TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes.
PubMed Identifier: 33849445
author list: Zhang G, Chitkushev L, Olsen LR, Keskin DB, Brusic V
published in: BMC bioinformatics
information resource reference: TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes. BMC Bioinformatics. 2021 Apr 14; 22(Suppl 8):40.
journal title abbreviation: BMC Bioinformatics
publication date: 2021-04-14T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders.
PubMed Identifier: 36268024
author list: Tabansky I, Tanaka AJ, Wang J, Zhang G, Dujmovic I, Mader S, Jeganathan V, DeAngelis T, Funaro M, Harel A, Messina M, Shabbir M, Nursey V, DeGouvia W, Laurent M, Blitz K, Jindra P, Gudesblatt M, King A, Drulovic J, Yunis E, Brusic V, Shen Y, Keskin DB, Najjar S, Stern JNH
published in: Frontiers in immunology
information resource reference: Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders. Front Immunol. 2022; 13:900605.
journal title abbreviation: Front Immunol
publication date: 2022-10-04T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1512303
type: Authorship
author rank in publication: 7
linked author: Keskin, Derin
linked information resource: HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.

HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.
PubMed Identifier: 36595954
author list: Weingarten-Gabbay S, Pearlman LR, Chen DY, Klaeger S, Taylor HB, Welch NL, Keskin DB, Carr SA, Abelin JG, Saeed M, Sabeti PC
published in: STAR protocols
information resource reference: HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses. STAR Protoc. 2022 12 16; 3(4):101910.
journal title abbreviation: STAR Protoc
publication date: 2022-12-08T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1522307
type: Authorship
author rank in publication: 6
linked author: Keskin, Derin
linked information resource: YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma.

YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma.
PubMed Identifier: 36719743
author list: Frost TC, Gartin AK, Liu M, Cheng J, Dharaneeswaran H, Keskin DB, Wu CJ, Giobbie-Hurder A, Thakuria M, DeCaprio JA
published in: The Journal of clinical investigation
information resource reference: YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. J Clin Invest. 2023 03 01; 133(5).
journal title abbreviation: J Clin Invest
publication date: 2023-03-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 249636
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: A review of the current use of rituximab in autoimmune diseases.

Ragon Institute of MGH, MIT and Harvard
type: Division
type: Organization

Authorship 1568964
type: Authorship
author rank in publication: 19
linked author: Keskin, Derin
linked information resource: ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer.

Authorship 1560357
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies.

Authorship 1568513
type: Authorship
author rank in publication: 6
linked author: Keskin, Derin
linked information resource: Protocol for Classification Single-Cell PBMC Types from Pathological Samples Using Supervised Machine Learning.

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies.
PubMed Identifier: 37035178
author list: Sei S, Ahadova A, Keskin DB, Bohaumilitzky L, Gebert J, von Knebel Doeberitz M, Lipkin SM, Kloor M
published in: Frontiers in oncology
information resource reference: Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies. Front Oncol. 2023; 13:1147590.
journal title abbreviation: Front Oncol
publication date: 2023-03-22T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Protocol for Classification Single-Cell PBMC Types from Pathological Samples Using Supervised Machine Learning.
PubMed Identifier: 37258906
author list: Lyu M, Xin L, Jin H, Chitkushev LT, Zhang G, Keskin DB, Brusic V
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Protocol for Classification Single-Cell PBMC Types from Pathological Samples Using Supervised Machine Learning. Methods Mol Biol. 2023; 2673:53-67.
journal title abbreviation: Methods Mol Biol
publication date: 2023-01-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer.
PubMed Identifier: 37430060
author list: Mota I, Patrucco E, Mastini C, Mahadevan NR, Thai TC, Bergaggio E, Cheong TC, Leonardi G, Karaca-Atabay E, Campisi M, Poggio T, Menotti M, Ambrogio C, Longo DL, Klaeger S, Keshishian H, Sztupinszki ZM, Szallasi Z, Keskin DB, Duke-Cohan JS, Reinhold B, Carr SA, Wu CJ, Moynihan KD, Irvine DJ, Barbie DA, Reinherz EL, Voena C, Awad MM, Blasco RB, Chiarle R
published in: Nature cancer
information resource reference: ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer. Nat Cancer. 2023 07; 4(7):1016-1035.
journal title abbreviation: Nat Cancer
publication date: 2023-07-10T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1584073
type: Authorship
author rank in publication: 13
linked author: Keskin, Derin
linked information resource: Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy.

Authorship 1591136
type: Authorship
author rank in publication: 9
linked author: Keskin, Derin
linked information resource: Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy.
PubMed Identifier: 37556329
author list: Bachireddy P, Azizi E, Burdziak C, Nguyen VN, Ennis CS, Maurer K, Park CY, Choo ZN, Li S, Gohil SH, Ruthen NG, Ge Z, Keskin DB, Cieri N, Livak KJ, Kim HT, Neuberg DS, Soiffer RJ, Ritz J, Alyea EP, Pe'er D, Wu CJ
published in: Cell reports
information resource reference: Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy. Cell Rep. 2023 Aug 29; 42(8):113011.
journal title abbreviation: Cell Rep
publication date: 2023-08-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.
PubMed Identifier: 37662211
author list: Truex NL, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, Sementa D, Touti F, Keskin DB, Wu CJ, Irvine DJ, Gómez-Bombarelli R, Pentelute BL
published in: bioRxiv : the preprint server for biology
information resource reference: Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons. bioRxiv. 2023 Sep 26.
journal title abbreviation: bioRxiv
publication date: 2023-09-26T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 375048
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Molecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap.

Authorship 393958
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.

Authorship 1597057
type: Authorship
author rank in publication: 16
linked author: Keskin, Derin
linked information resource: The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.

The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma.
PubMed Identifier: 37819236
author list: Durall RT, Huang J, Wojenski L, Huang Y, Gokhale PC, Leeper BA, Nash JO, Ballester PL, Davidson S, Shlien A, Sotirakis E, Bertaux F, Dubus V, Luo J, Wu CJ, Keskin DB, Eagen KP, Shapiro GI, French CA
published in: Cancer research
information resource reference: The BRD4-NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma. Cancer Res. 2023 12 01; 83(23):3846-3860.
journal title abbreviation: Cancer Res
publication date: 2023-12-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1601463
type: Authorship
author rank in publication: 6
linked author: Keskin, Derin
linked information resource: Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8aß+ T cells targeting multiple myeloma.

Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8aß+ T cells targeting multiple myeloma.
PubMed Identifier: 37890146
author list: Bae J, Kitayama S, Herbert Z, Daheron L, Kurata K, Keskin DB, Livak K, Li S, Tarannum M, Romee R, Samur M, Munshi NC, Kaneko S, Ritz J, Anderson KC
published in: Blood
information resource reference: Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8aß+ T cells targeting multiple myeloma. Blood. 2024 03 07; 143(10):895-911.
journal title abbreviation: Blood
publication date: 2024-03-07T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1605524
type: Authorship
author rank in publication: 16
linked author: Keskin, Derin
linked information resource: Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies.

Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies.
PubMed Identifier: 37942334
author list: Yin S, Klaeger S, Chea VA, Carulli IP, Rachimi S, Black KE, Filbin M, Hariri LP, Knipe RS, Padera RF, Stevens JD, Lane WJ, Carr SA, Wu CJ, Kim EY, Keskin DB
published in: Frontiers in immunology
information resource reference: Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies. Front Immunol. 2023; 14:1269335.
journal title abbreviation: Front Immunol
publication date: 2023-10-20T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Dictionary of immune responses to cytokines at single-cell resolution.
PubMed Identifier: 38057668
author list: Cui A, Huang T, Li S, Ma A, Pérez JL, Sander C, Keskin DB, Wu CJ, Fraenkel E, Hacohen N
published in: Nature
information resource reference: Dictionary of immune responses to cytokines at single-cell resolution. Nature. 2024 01; 625(7994):377-384.
journal title abbreviation: Nature
publication date: 2023-12-06T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1611829
type: Authorship
author rank in publication: 7
linked author: Keskin, Derin
linked information resource: Dictionary of immune responses to cytokines at single-cell resolution.

Genetically engineered mouse model to improve therapy of NUT carcinoma
end date: 2028-08-31
principal investigator name: FRENCH, CHRISTOPHER A
start date: 2023-09-19
type: Grant
sponsor award id: R01CA285308

Co-Principal Investigator
type: Researcher Role
researcher role of: Keskin, Derin
contributes to: Genetically engineered mouse model to improve therapy of NUT carcinoma

Authorship 1627319
type: Authorship
author rank in publication: 10
linked author: Keskin, Derin
linked information resource: Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy.

Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy.
PubMed Identifier: 38317797
author list: Kuai R, Singh PB, Sun X, Xu C, Najafabadi AH, Scheetz L, Yuan W, Xu Y, Hong H, Keskin DB, Wu CJ, Jain R, Schwendeman A, Moon JJ
published in: Advanced therapeutics
information resource reference: Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy. Adv Ther (Weinh). 2020 Sep; 3(9).
journal title abbreviation: Adv Ther (Weinh)
publication date: 2020-06-23T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1638036
type: Authorship
author rank in publication: 26
linked author: Keskin, Derin
linked information resource: CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.

Authorship 1639185
type: Authorship
author rank in publication: 16
linked author: Keskin, Derin
linked information resource: Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination.

CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness.
PubMed Identifier: 38489372
author list: Qin X, Lam A, Zhang X, Sengupta S, Iorgulescu JB, Ni H, Das S, Rager M, Zhou Z, Zuo T, Meara GK, Floru AE, Kemet C, Veerapaneni D, Kashy D, Lin L, Lloyd K, Kwok L, Smith KS, Nagaraju RT, Meijers R, Ceol C, Liu CT, Alexandrescu S, Wu CJ, Keskin DB, George RE, Feng H
published in: Science advances
information resource reference: CKLF instigates a "cold" microenvironment to promote MYCN-mediated tumor aggressiveness. Sci Adv. 2024 03 15; 10(11):eadh9547.
journal title abbreviation: Sci Adv
publication date: 2024-03-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination.
PubMed Identifier: 38491184
author list: Zeng YC, Young OJ, Wintersinger CM, Anastassacos FM, MacDonald JI, Isinelli G, Dellacherie MO, Sobral M, Bai H, Graveline AR, Vernet A, Sanchez M, Mulligan K, Choi Y, Ferrante TC, Keskin DB, Fell GG, Neuberg D, Wu CJ, Mooney DJ, Kwon IC, Ryu JH, Shih WM
published in: Nature nanotechnology
information resource reference: Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination. Nat Nanotechnol. 2024 Jul; 19(7):1055-1065.
journal title abbreviation: Nat Nanotechnol
publication date: 2024-03-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Merkel cell polyomavirus HLA class I epitopes for generating therapeutic T cell-based cancer immunotherapy
end date: 2028-12-31
principal investigator name: KESKIN, DERIN B
start date: 2024-01-09
type: Grant
sponsor award id: R01CA279391

Principal Investigator
type: Researcher Role
researcher role of: Keskin, Derin
contributes to: Merkel cell polyomavirus HLA class I epitopes for generating therapeutic T cell-based cancer immunotherapy

Systematic identification of minor histocompatibility antigens to address GVHD
end date: 2026-03-31
principal investigator name: KESKIN, DERIN B
start date: 2022-04-01
type: Grant
sponsor award id: R01HL157174

Principal Investigator
type: Researcher Role
researcher role of: Keskin, Derin
contributes to: Systematic identification of minor histocompatibility antigens to address GVHD

Authorship 1652156
type: Authorship
author rank in publication: 9
linked author: Keskin, Derin
linked information resource: Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.
PubMed Identifier: 38680558
author list: Truex NL, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, Sementa D, Touti F, Keskin DB, Wu CJ, Irvine DJ, Gómez-Bombarelli R, Pentelute BL
published in: ACS central science
information resource reference: Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons. ACS Cent Sci. 2024 Apr 24; 10(4):793-802.
journal title abbreviation: ACS Cent Sci
publication date: 2024-03-06T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor in Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Neurology
position in organization: Massachusetts General Hospital

Phillip T. and Susan M. Ragon Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Ragon Institute of MGH, MIT and Harvard
sort order: 1
type: Position
HR job title: Phillip T. and Susan M. Ragon Professor of Medicine
position in organization: Massachusetts General Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Jerome and Nancy Kohlberg Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Jerome and Nancy Kohlberg Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Kraft Family Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Adult Oncology
sort order: 1
type: Position
HR job title: Kraft Family Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Rheumatology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 303881
type: Authorship
author rank in publication: 6
linked author: Keskin, Derin
linked information resource: Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.

Authorship 1687367
type: Authorship
author rank in publication: 29
linked author: Keskin, Derin
linked information resource: Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.

Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.
PubMed Identifier: 39169264
author list: Cieri N, Hookeri N, Stromhaug K, Li L, Keating J, Díaz-Fernández P, Gómez-García de Soria V, Stevens J, Kfuri-Rubens R, Shao Y, Kooshesh KA, Powell K, Ji H, Hernandez GM, Abelin J, Klaeger S, Forman C, Clauser KR, Sarkizova S, Braun DA, Penter L, Kim HT, Lane WJ, Oliveira G, Kean LS, Li S, Livak KJ, Carr SA, Keskin DB, Muñoz-Calleja C, Ho VT, Ritz J, Soiffer RJ, Neuberg D, Stewart C, Getz G, Wu CJ
published in: Nature biotechnology
information resource reference: Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation. Nat Biotechnol. 2025 Jun; 43(6):971-982.
journal title abbreviation: Nat Biotechnol
publication date: 2024-08-21T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanisms of lmmunosuppression in MYCN-driven Neuroblastoma
end date: 2029-11-30
principal investigator name: FENG, HUI
start date: 2024-12-01
type: Grant
sponsor award id: R01NS140967

Co-Principal Investigator
type: Researcher Role
researcher role of: Keskin, Derin
contributes to: Mechanisms of lmmunosuppression in MYCN-driven Neuroblastoma

CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity.
PubMed Identifier: 39713349
author list: Fisher RJ, Park K, Lee K, Pinjusic K, Vanasse A, Ennis CS, Ficcaro S, Marto J, Stransky S, Duke-Cohan J, Geethadevi A, Raabe E, Sidoli S, Hicks CW, Keskin DB, Wu CJ, Cole PA, Alani RM
published in: bioRxiv : the preprint server for biology
information resource reference: CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity. bioRxiv. 2024 Dec 12.
journal title abbreviation: bioRxiv
publication date: 2024-12-12T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1720814
type: Authorship
author rank in publication: 15
linked author: Keskin, Derin
linked information resource: CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity.

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.
PubMed Identifier: 40023154
author list: Jiang Q, Braun DA, Clauser KR, Ramesh V, Shirole NH, Duke-Cohan JE, Nabilsi N, Kramer NJ, Forman C, Lippincott IE, Klaeger S, Phulphagar KM, Chea V, Kim N, Vanasse AP, Saad E, Parsons T, Carr-Reynolds M, Carulli I, Pinjusic K, Jiang Y, Li R, Syamala S, Rachimi S, Verzani EK, Stevens JD, Lane WJ, Camp SY, Meli K, Pappalardi MB, Herbert ZT, Qiu X, Cejas P, Long HW, Shukla SA, Van Allen EM, Choueiri TK, Churchman LS, Abelin JG, Gurer C, MacBeath G, Childs RW, Carr SA, Keskin DB, Wu CJ, Kaelin WG
published in: Cell
information resource reference: HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy. Cell. 2025 Apr 03; 188(7):1807-1827.e34.
journal title abbreviation: Cell
publication date: 2025-02-28T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1732490
type: Authorship
author rank in publication: 31
linked author: Keskin, Derin
linked information resource: A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings.

Authorship 1732725
type: Authorship
author rank in publication: 48
linked author: Keskin, Derin
linked information resource: A neoantigen vaccine generates antitumour immunity in renal cell carcinoma.

Authorship 1730893
type: Authorship
author rank in publication: 44
linked author: Keskin, Derin
linked information resource: HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings.
PubMed Identifier: 39906744
author list: Treon SP, Kotton CN, Park DJ, Moranzoni G, Lemvigh CK, Gathe JC, Varughese TA, Barnett CF, Belenchia JM, Clark NM, Farber CM, Abid MB, Ahmed G, Patterson CJ, Guerrera ML, Soumerai JD, Chea VA, Carulli IP, Southard J, Li S, Wu CJ, Livak KJ, Holmgren E, Kim P, Shi C, Lin H, Ramakrishnan V, Ou Y, Olszewski S, Olsen LR, Keskin DB, Hunter ZR, Tankersley C, Zimmerman T, Dhakal B
published in: Frontiers in immunology
information resource reference: A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings. Front Immunol. 2024; 15:1369619.
journal title abbreviation: Front Immunol
publication date: 2025-01-21T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

A neoantigen vaccine generates antitumour immunity in renal cell carcinoma.
PubMed Identifier: 39910301
author list: Braun DA, Moranzoni G, Chea V, McGregor BA, Blass E, Tu CR, Vanasse AP, Forman C, Forman J, Afeyan AB, Schindler NR, Liu Y, Li S, Southard J, Chang SL, Hirsch MS, LeBoeuf NR, Olive O, Mehndiratta A, Greenslade H, Shetty K, Klaeger S, Sarkizova S, Pedersen CB, Mossanen M, Carulli I, Tarren A, Duke-Cohan J, Howard AA, Iorgulescu JB, Shim B, Simon JM, Signoretti S, Aster JC, Elagina L, Carr SA, Leshchiner I, Getz G, Gabriel S, Hacohen N, Olsen LR, Oliveira G, Neuberg DS, Livak KJ, Shukla SA, Fritsch EF, Wu CJ, Keskin DB, Ott PA, Choueiri TK
published in: Nature
information resource reference: A neoantigen vaccine generates antitumour immunity in renal cell carcinoma. Nature. 2025 03; 639(8054):474-482.
journal title abbreviation: Nature
publication date: 2025-02-05T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 210977
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy.

Authorship 236979
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.

Authorship 240428
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.
PubMed Identifier: 40645179
author list: Blass E, Keskin DB, Tu CR, Forman C, Vanasse A, Sax HE, Shim B, Chea V, Kim N, Carulli I, Southard J, Lyu H, Lu W, Rickles-Young M, Afeyan AB, Olive O, Mehndiratta A, Greenslade H, Shetty K, Baginska J, Gomez Diaz I, Nau A, Pfaff KL, Gans A, Ranasinghe S, Buchbinder EI, Sussman TA, Insco ML, Yoon CH, Rodig SJ, Shukla SA, Li S, Aster JC, Braun DA, Cibulskis C, Hacohen N, Neuberg DS, Giobbie-Hurder A, Livak KJ, Fritsch EF, Oliveira G, Simon JM, Wu CJ, Ott PA
published in: Cell
information resource reference: A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma. Cell. 2025 Sep 18; 188(19):5125-5141.e27.
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Authorship 706823
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linked information resource: HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.

HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.
PubMed Identifier: 24705205
author list: Zhang GL, Riemer AB, Keskin DB, Chitkushev L, Reinherz EL, Brusic V
published in: Database : the journal of biological databases and curation
information resource reference: HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology. Database (Oxford). 2014; 2014:bau031.
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CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.
PubMed Identifier: 41364533
author list: Fisher RJ, Park K, Lee K, Pinjusic K, Vanasse A, Ennis CS, Farokh P, Ficaro SB, Marto JA, Jiang H, Nam E, Stransky S, Duke-Cohan J, Akinci MA, Geethadevi A, Raabe E, Fiszbein A, Demehri S, Sidoli S, Hicks CW, Keskin DB, Wu CJ, Cole PA, Alani RM
published in: JCI insight
information resource reference: CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity. JCI Insight. 2026 Jan 23; 11(2).
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Authorship 734111
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author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.

Authorship 734112
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author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.
PubMed Identifier: 24849600
author list: Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL
published in: The Journal of biological chemistry
information resource reference: Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92.
journal title abbreviation: J Biol Chem
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Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.
PubMed Identifier: 24891321
author list: Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, Zhang W, Sougnez C, Cibulskis K, Sidney J, Stevenson K, Ritz J, Neuberg D, Brusic V, Gabriel S, Lander ES, Getz G, Hacohen N, Wu CJ
published in: Blood
information resource reference: Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014 Jul 17; 124(3):453-62.
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Authorship 1771862
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author rank in publication: 21
linked author: Keskin, Derin
linked information resource: CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

Authorship 1777103
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author rank in publication: 2
linked author: Keskin, Derin
linked information resource: A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.

Authorship 1813591
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author rank in publication: 22
linked author: Keskin, Derin
linked information resource: Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.

Authorship 1836363
type: Authorship
author rank in publication: 17
linked author: Keskin, Derin
linked information resource: Sensitive detection of cancer antigens enabled by user-defined peptide libraries.

Authorship 1852598
type: Authorship
author rank in publication: 12
linked author: Keskin, Derin
linked information resource: Evolution of tumor subclones and T-cell dynamics underlie variable ibrutinib responses in Waldenström macroglobulinemia.

Authorship 1851175
type: Authorship
author rank in publication: 16
linked author: Keskin, Derin
linked information resource: Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity.

Sensitive detection of cancer antigens enabled by user-defined peptide libraries.
PubMed Identifier: 41663542
author list: Manakongtreecheep K, Ctortecka C, Correa-Medero LO, Zhu T, Lippincott I, Lawrence GM, Howard A, Hernandez GM, Forman C, Duggan EC, Wilbrink MA, Verzani EK, Afeyan AB, Li J, Nesvizhskii AI, Oliveira G, Keskin DB, Ott PA, Clauser KR, Bakalar M, Sarkizova S, Hacohen N, Carr SA, Abelin JG, Wu CJ
published in: Nature biotechnology
information resource reference: Sensitive detection of cancer antigens enabled by user-defined peptide libraries. Nat Biotechnol. 2026 Feb 09.
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Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.
PubMed Identifier: 41332750
author list: Xie H, Jiang A, Dey A, Dean JW, Perera JJ, Smith NP, Chen ACY, Anderson S, Cicerchia AM, Sun Y, Michaud WA, Florentin M, Fang J, Revach OY, Sharova T, Lawless A, Xu KH, Song Y, Patel B, Stevens JD, Lane WJ, Keskin DB, Cohen S, Lawrence DP, Sullivan RJ, Flaherty KT, Boland GM, Nieman LT, Sade-Feldman M, Hacohen N, Sen DR, Wu C, Gastman B, Qi R, Yin H, Villani AC, Manguso RT, Jenkins RW
published in: bioRxiv : the preprint server for biology
information resource reference: Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL. bioRxiv. 2025 Nov 20.
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Evolution of tumor subclones and T-cell dynamics underlie variable ibrutinib responses in Waldenström macroglobulinemia.
PubMed Identifier: 41671559
author list: Sun H, Sklavenitis Pistofidis R, Liu S, Liu X, Tsakmaklis N, Hatcher JM, Guerrera ML, Kofides A, Ramirez-Gamero AF, Peachey A, Li S, Keskin D, Chea V, Kim N, Lyu H, Lu W, Livak KJ, Meid KE, Guijosa A, Flynn C, Pizzarella D, Patterson CJ, Hao M, Yi S, Yuan W, Branagan AR, Wu CJ, Ghobrial IM, Qiu L, Sarosiek S, Castillo JJ, Hunter ZR, Treon SP
published in: Blood
information resource reference: Evolution of tumor subclones and T-cell dynamics underlie variable ibrutinib responses in Waldenström macroglobulinemia. Blood. 2026 Feb 11.
journal title abbreviation: Blood
publication date: 2026-02-11T00:00:00
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Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity.
PubMed Identifier: 41424801
author list: Tabansky Stern I, Wang J, Moldwin RM, Kim JM, Singh JH, Tran DC, Najjar S, Akinci M, Howard A, Duke-Cohan JE, Belhaj M, Stevens J, Lane WJ, Birder LA, Jackson EK, Keskin DB, Zhang G, Stern JNH
published in: Frontiers in molecular medicine
information resource reference: Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity. Front Mol Med. 2025; 5:1712660.
journal title abbreviation: Front Mol Med
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Authorship 32529
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.

Senior Lecturer on Biostatistics, Emerita
is primary position: true
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position in organization: Harvard T.H. Chan School of Public Health

Authorship 457013
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1077059

Authorship 758739
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.
PubMed Identifier: 25237310
author list: Reinherz EL, Keskin DB, Reinhold B
published in: Frontiers in immunology
information resource reference: Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides. Front Immunol. 2014; 5:418.
journal title abbreviation: Front Immunol
publication date: 2014-09-04T00:00:00
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Authorship 6450
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Impaired B cell development and function in the absence of IkappaBNS.

Authorship 494851
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens.

Authorship 500695
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme.

Authorship 776208
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.

Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.
PubMed Identifier: 25505899
author list: Zhang GL, Keskin DB, Lin HN, Lin HH, DeLuca DS, Leppanen S, Milford EL, Reinherz EL, Brusic V
published in: Frontiers in immunology
information resource reference: Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis. Front Immunol. 2014; 5:597.
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publication date: 2014-11-27T00:00:00
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Authorship 778774
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.
PubMed Identifier: 25556239
author list: Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL
published in: The Journal of biological chemistry
information resource reference: Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2015 Jan 2; 290(1):239.
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Authorship 780324
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.

Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.
PubMed Identifier: 25605925
author list: Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22.
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type: Information Resource

Authorship 780709
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.

Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.
PubMed Identifier: 25646416
author list: Keskin DB, Reinhold BB, Zhang GL, Ivanov AR, Karger BL, Reinherz EL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2151-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-02-02T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 3237
type: Authorship
author rank in publication: 8
linked author: Keskin, Derin
linked information resource: Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery.

Authorship 72082
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments.

Authorship 548378
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.

Authorship 311851
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Developmental bias in cleavage-stage mouse blastomeres.

Authorship 23514
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Tryptophan catabolism and T cell responses.

Authorship 338924
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.

Authorship 333667
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Dana-Farber repository for machine learning in immunology.

Authorship 402652
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author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Bioinformatic identification and characterization of human endothelial cell-restricted genes.

Authorship 414088
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author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Possible role of natural killer cells in pemphigus vulgaris - preliminary observations.

Authorship 552220
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author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products.

Authorship 394847
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author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.

Authorship 424467
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis.

Authorship 145465
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.

Authorship 314880
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: The role of natural killer cells in autoimmune blistering diseases.

Authorship 33965
type: Authorship
author rank in publication: 6
linked author: Keskin, Derin
linked information resource: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.

Authorship 415801
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid.

Authorship 803239
type: Authorship
author rank in publication: 1
linked author: Keskin, Derin
linked information resource: Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.

Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.
PubMed Identifier: 25848066
author list: Keskin DB, Reinhold BR, Zhang GL, Ivanov AR, Karger BL, Reinherz EL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):E2418.
journal title abbreviation: Proc Natl Acad Sci U S A
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type: Academic Article
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Authorship 426966
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.

Authorship 839039
type: Authorship
author rank in publication: 12
linked author: Keskin, Derin
linked information resource: Advancing drug delivery systems for the treatment of multiple sclerosis.

Advancing drug delivery systems for the treatment of multiple sclerosis.
PubMed Identifier: 26475738
author list: Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P, Najjar S, Cao Y, Sands W, Keskin DB, Stern JN
published in: Immunologic research
information resource reference: Advancing drug delivery systems for the treatment of multiple sclerosis. Immunol Res. 2015 Dec; 63(1-3):58-69.
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publication date: 2015-12-01T00:00:00
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type: Academic Article
type: Article
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Authorship 390795
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy.

Authorship 467531
type: Authorship
author rank in publication: 4
linked author: Keskin, Derin
linked information resource: Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.

Authorship 326081
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.

Assistant Professor
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Associate Professor
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Full Professor
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Instructor
sort order: 4
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Other Faculty
sort order: 5
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Authorship 95295
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination.

Authorship 891105
type: Authorship
author rank in publication: 12
linked author: Keskin, Derin
linked information resource: Erratum to: Advancing drug delivery systems for the treatment of multiple sclerosis.

Erratum to: Advancing drug delivery systems for the treatment of multiple sclerosis.
PubMed Identifier: 26895430
author list: Tabansky I, Messina MD, Bangeranye C, Goldstein J, Blitz-Shabbir KM, Machado S, Jeganathan V, Wright P, Najjar S, Cao Y, Sands W, Keskin DB, Stern JN
published in: Immunologic research
information resource reference: Erratum to: Advancing drug delivery systems for the treatment of multiple sclerosis. Immunol Res. 2016 Apr; 64(2):640.
journal title abbreviation: Immunol Res
publication date: 2016-04-01T00:00:00
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type: Academic Article
type: Article
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Authorship 64185
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.

Authorship 364731
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.

Authorship 928326
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.

Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.
PubMed Identifier: 27668268
author list: Bae J, Keskin DB, Cowens K, Lee AH, Dranoff G, Munshi NC, Anderson KC
published in: Journal of leukemia (Los Angeles, Calif.)
information resource reference: Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors. J Leuk (Los Angel). 2015 Jun; 3(2).
journal title abbreviation: J Leuk (Los Angel)
publication date: 2015-04-21T00:00:00
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type: Academic Article
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Authorship 568260
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: Copolymer effects on microglia and T cells in the central nervous system of humanized mice.

Authorship 958513
type: Authorship
author rank in publication: 2
linked author: Keskin, Derin
linked information resource: Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.
PubMed Identifier: 28228285
author list: Abelin JG, Keskin DB, Sarkizova S, Hartigan CR, Zhang W, Sidney J, Stevens J, Lane W, Zhang GL, Eisenhaure TM, Clauser KR, Hacohen N, Rooney MS, Carr SA, Wu CJ
published in: Immunity
information resource reference: Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction. Immunity. 2017 02 21; 46(2):315-326.
journal title abbreviation: Immunity
publication date: 2017-02-21T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme.
PubMed Identifier: 11375052
author list: Marshall B, Keskin DB, Mellor AL
published in: BMC biochemistry
information resource reference: Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme. BMC Biochem. 2001; 2:5.
journal title abbreviation: BMC Biochem
publication date: 2001-05-17T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.
PubMed Identifier: 15665083
author list: Stern JN, Illés Z, Reddy J, Keskin DB, Fridkis-Hareli M, Kuchroo VK, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1620-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-01-21T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 964979
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.

Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.
PubMed Identifier: 25941601
author list: Bae J, Samur M, Munshi A, Hideshima T, Keskin D, Kimmelman A, Lee AH, Dranoff G, Anderson KC, Munshi NC
published in: Oncoimmunology
information resource reference: Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells. Oncoimmunology. 2014; 3(12):e970914.
journal title abbreviation: Oncoimmunology
publication date: 2014-12-02T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells.
PubMed Identifier: 11751753
author list: Fallarino F, Vacca C, Orabona C, Belladonna ML, Bianchi R, Marshall B, Keskin DB, Mellor AL, Fioretti MC, Grohmann U, Puccetti P
published in: International immunology
information resource reference: Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. Int Immunol. 2002 Jan; 14(1):65-8.
journal title abbreviation: Int Immunol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.
PubMed Identifier: 17360654
author list: Keskin DB, Allan DS, Rybalov B, Andzelm MM, Stern JN, Kopcow HD, Koopman LA, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3378-83.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-02-20T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.
PubMed Identifier: 15292514
author list: Stern JN, Illés Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11743-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-08-03T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Possible role of natural killer cells in pemphigus vulgaris - preliminary observations.
PubMed Identifier: 18373702
author list: Stern JN, Keskin DB, Barteneva N, Zuniga J, Yunis EJ, Ahmed AR
published in: Clinical and experimental immunology
information resource reference: Possible role of natural killer cells in pemphigus vulgaris - preliminary observations. Clin Exp Immunol. 2008 Jun; 152(3):472-81.
journal title abbreviation: Clin Exp Immunol
publication date: 2008-03-28T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
PubMed Identifier: 12385839
author list: Mellor AL, Chandler P, Lee GK, Johnson T, Keskin DB, Lee J, Munn DH
published in: Journal of reproductive immunology
information resource reference: Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy. J Reprod Immunol. 2002 Oct-Nov; 57(1-2):143-50.
journal title abbreviation: J Reprod Immunol
publication date: 2002-10-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.
PubMed Identifier: 16674822
author list: Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabuzda D, Reinherz EL
published in: Medical immunology (London, England)
information resource reference: Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006 May 18; 5:1.
journal title abbreviation: Med Immunol
publication date: 2006-05-18T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination.
PubMed Identifier: 22775998
author list: Riemer AB, Keskin DB, Reinherz EL
published in: Experimental dermatology
information resource reference: Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination. Exp Dermatol. 2012 Aug; 21(8):625-9.
journal title abbreviation: Exp Dermatol
publication date: 2012-08-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Tryptophan catabolism and T cell responses.
PubMed Identifier: 15206713
author list: Mellor AL, Munn D, Chandler P, Keskin D, Johnson T, Marshall B, Jhaver K, Baban B
published in: Advances in experimental medicine and biology
information resource reference: Tryptophan catabolism and T cell responses. Adv Exp Med Biol. 2003; 527:27-35.
journal title abbreviation: Adv Exp Med Biol
publication date: 2003-01-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 996785
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: An immunogenic personal neoantigen vaccine for patients with melanoma.

An immunogenic personal neoantigen vaccine for patients with melanoma.
PubMed Identifier: 28678778
author list: Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ
published in: Nature
information resource reference: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 07 13; 547(7662):217-221.
journal title abbreviation: Nature
publication date: 2017-07-05T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.
PubMed Identifier: 17103092
author list: Keskin DB, Marshall B, Munn D, Mellor AL, Gearhart DA
published in: Cellular & molecular biology letters
information resource reference: Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase. Cell Mol Biol Lett. 2007; 12(1):82-102.
journal title abbreviation: Cell Mol Biol Lett
publication date: 2006-11-13T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy.
PubMed Identifier: 22566858
author list: Olsen LR, Zhang GL, Keskin DB, Reinherz EL, Brusic V
published in: Frontiers in immunology
information resource reference: Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy. Front Immunol. 2011; 2:69.
journal title abbreviation: Front Immunol
publication date: 2011-12-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.
PubMed Identifier: 20160060
author list: Ofran Y, Kim HT, Brusic V, Blake L, Mandrell M, Wu CJ, Sarantopoulos S, Bellucci R, Keskin DB, Soiffer RJ, Antin JH, Ritz J
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes. Clin Cancer Res. 2010 Mar 01; 16(5):1642-51.
journal title abbreviation: Clin Cancer Res
publication date: 2010-02-16T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells.
PubMed Identifier: 20855626
author list: Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17280-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-09-20T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1008985
type: Authorship
author rank in publication: 3
linked author: Keskin, Derin
linked information resource: TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.
PubMed Identifier: 28872670
author list: Yoshizawa A, Bi K, Keskin DB, Zhang G, Reinhold B, Reinherz EL
published in: European journal of immunology
information resource reference: TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells. Eur J Immunol. 2018 01; 48(1):128-150.
journal title abbreviation: Eur J Immunol
publication date: 2017-09-29T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Impaired B cell development and function in the absence of IkappaBNS.
PubMed Identifier: 21900180
author list: Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Impaired B cell development and function in the absence of IkappaBNS. J Immunol. 2011 Oct 15; 187(8):3942-52.
journal title abbreviation: J Immunol
publication date: 2011-09-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1022637
type: Authorship
author rank in publication: 5
linked author: Keskin, Derin
linked information resource: Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.

Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma.
PubMed Identifier: 29089645
author list: Bae J, Hideshima T, Zhang GL, Zhou J, Keskin DB, Munshi NC, Anderson KC
published in: Leukemia
information resource reference: Identification and characterization of HLA-A24-specific XBP1, CD138 (Syndecan-1) and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma. Leukemia. 2018 03; 32(3):752-764.
journal title abbreviation: Leukemia
publication date: 2017-11-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

450 Brookline Ave
type: Address
address line 1: Dana-Farber Cancer Institute
address line 2: Lc4215j
address line 3: 450 Brookline Ave
city: Boston
postal code: 02215
state or province: MA

Dana-Farber repository for machine learning in immunology.
PubMed Identifier: 21782820
author list: Zhang GL, Lin HH, Keskin DB, Reinherz EL, Brusic V
published in: Journal of immunological methods
information resource reference: Dana-Farber repository for machine learning in immunology. J Immunol Methods. 2011 Nov 30; 374(1-2):18-25.
journal title abbreviation: J Immunol Methods
publication date: 2011-07-18T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of natural killer cells in autoimmune blistering diseases.
PubMed Identifier: 21923616
author list: Zakka LR, Fradkov E, Keskin DB, Tabansky I, Stern JN, Ahmed AR
published in: Autoimmunity
information resource reference: The role of natural killer cells in autoimmune blistering diseases. Autoimmunity. 2012 Feb; 45(1):44-54.
journal title abbreviation: Autoimmunity
publication date: 2011-09-19T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap.
PubMed Identifier: 20932029
author list: Reinhold B, Keskin DB, Reinherz EL
published in: Analytical chemistry
information resource reference: Molecular detection of targeted major histocompatibility complex I-bound peptides using a probabilistic measure and nanospray MS3 on a hybrid quadrupole-linear ion trap. Anal Chem. 2010 Nov 01; 82(21):9090-9.
journal title abbreviation: Anal Chem
publication date: 2010-10-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.
PubMed Identifier: 22866951
author list: Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH
published in: BMC genomics
information resource reference: Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing. BMC Genomics. 2012 Aug 06; 13:378.
journal title abbreviation: BMC Genomics
publication date: 2012-08-06T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.
PubMed Identifier: 17641034
author list: Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 01; 179(3):1681-92.
journal title abbreviation: J Immunol
publication date: 2007-08-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Physical detection of HLA-C binding peptides to identify and predict immunogenic personal neoepitopes for improving cancer vaccines
end date: 2019-12-31
principal investigator name: KESKIN, DERIN B
start date: 2018-01-16
type: Grant
sponsor award id: R21CA216772

Principal Investigator
type: Researcher Role
researcher role of: Keskin, Derin
contributes to: Physical detection of HLA-C binding peptides to identify and predict immunogenic personal neoepitopes for improving cancer vaccines