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Proceedings of the National Academy of Sciences of the United States of America
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Science's STKE : signal transduction knowledge environment
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International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
REMOVED: Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5.
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Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N, Brenner GJ, Breakefield XO
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miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
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Multidimensional communication in the microenvirons of glioblastoma. Nat Rev Neurol. 2018 08; 14(8):482-495.
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Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
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Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain.
Albert H. Coons Professor of Neurology in the Field of Immunologic Diseases
Harvey W. Cushing and Daniel E. Ponton Professor of Neurosurgery
Samuel L. Wasserstrom Professor of Neurology
Gyuris A, Navarrete-Perea J, Jo A, Cristea S, Zhou S, Fraser K, Wei Z, Krichevsky AM, Weissleder R, Lee H, Gygi SP, Charest A
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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21.
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Environmental enrichment prevents Aß oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways.
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Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells. Cell Rep. 2020 02 18; 30(7):2065-2074.e4.
Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.
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Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes. JCO Clin Cancer Inform. 2020 05; 4:421-435.
Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes.
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Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism. iScience. 2020 Aug 21; 23(8):101420.
Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism.
Testing miR-132 signaling and replacement as a common strategy for AD, FTD, and related pathologies
Epigenetics and 3D Structure of miR-10b/HoxD Locus in the Brain and Malignant Glioma
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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD-L1. Mol Oncol. 2021 Feb 01.
Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD-L1.
Uhlmann EJ, Rabinovsky R, Varma H, El Fatimy R, Kasper EM, Moore JM, Vega RA, Thomas AJ, Alterman RL, Stippler M, Anderson MP, Uhlmann EN, Kipper FC, Krichevsky AM
Journal of neuropathology and experimental neurology
Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology. J Neuropathol Exp Neurol. 2021 12 29; 80(12):1117-1124.
Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology.
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A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing. Mol Cancer. 2022 01 15; 21(1):17.
A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing.
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Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. Mol Cell. 2022 05 19; 82(10):1894-1908.e5.
Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma.
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Correction to: Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology.
Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, Peshkin L, Uhlmann EJ, Krichevsky AM
Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Mol Ther Nucleic Acids. 2023 Mar 14; 31:265-275.
Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma.
Uhlmann EJ, Mackel CE, Deforzh E, Rabinovsky R, Brastianos PK, Varma H, Vega RA, Krichevsky AM
Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability. J Neurooncol. 2023 Mar; 162(1):109-118.
Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability.
Deforzh E, Kharel P, Karelin A, Ivanov P, Krichevsky AM
bioRxiv : the preprint server for biology
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide. bioRxiv. 2023 Jun 30.
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide.
Krichevsky A, Nguyen L, Wei Z, Silva M, Barberán-Soler S, Rabinovsky R, Muratore C, Stricker J, Hortman C, Young-Pearse T, Haggarty S
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Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing.
Shields Warren-Mallinckrodt Professor of Medical Research
Nguyen LD, Wei Z, Silva MC, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. Nat Commun. 2023 11 21; 14(1):7575.
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.
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Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets-Recent Insights at Molecular and Cellular Level. Cells. 2023 11 20; 12(22).
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HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding. Mol Cell. 2024 Oct 17; 84(20):3950-3966.e6.
HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding.
Absalon S, Kochanek DM, Raghavan V, Krichevsky AM
MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013 Sep 11; 33(37):14645-59.
MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.
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A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cells. Sci Signal. 2025 Apr 15; 18(882):eads2641.
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cells.
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Lipid nanoparticle formulation for gene editing and RNA-based therapies for glioblastoma. Neuro Oncol. 2025 Nov 01; 27(11):2812-2827.
Lipid nanoparticle formulation for gene editing and RNA-based therapies for glioblastoma.
tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathies
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Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation. Sci Adv. 2026 Feb 13; 12(7):eadz8331.
Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation.
miR-10b Gene Editing Therapy for Glioblastoma
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Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan; 77(1):75-99.
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
Godlewski J, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A
Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62.
Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.
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Molecular therapy : the journal of the American Society of Gene Therapy
The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. Mol Ther. 2015 Jul; 23(7):1234-1247.
The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.
Ansari KI, Ogawa D, Rooj AK, Lawler SE, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A, Godlewski J
Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909.
Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor.
Teplyuk NM, Uhlmann EJ, Wong AH, Karmali P, Basu M, Gabriely G, Jain A, Wang Y, Chiocca EA, Stephens R, Marcusson E, Yi M, Krichevsky AM
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Biogenesis, delivery, and function of extracellular RNA.
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Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS.
van der Vos KE, Abels ER, Zhang X, Lai C, Carrizosa E, Oakley D, Prabhakar S, Mardini O, Crommentuijn MH, Skog J, Krichevsky AM, Stemmer-Rachamimov A, Mempel TR, El Khoury J, Hickman SE, Breakefield XO
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain. Neuro Oncol. 2016 Jan; 18(1):58-69.
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.
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Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87.
Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic.
Wei Z, Batagov AO, Carter DR, Krichevsky AM
Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA. Sci Rep. 2016 08 09; 6:31175.
Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA.
exRNA released by glioblastoma alters brain microenvironment
Angiogenin and its small RNA products in glioblastoma and brain microenvironment
Validation of microRNA Targets in Glioma
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Self-neutralizing oligonucleotides with enhanced cellular uptake.
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Genetic architecture of age-related cognitive decline in African Americans. Neurol Genet. 2017 Feb; 3(1):e125.
Genetic architecture of age-related cognitive decline in African Americans.
El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM
Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. Mol Ther. 2017 Feb 01; 25(2):368-378.
Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b.
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Teaching resources. A model for local regulation of translation near active synapses.
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Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease.
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Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants.
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A microRNA array reveals extensive regulation of microRNAs during brain development. RNA. 2003 Oct; 9(10):1274-81.
A microRNA array reveals extensive regulation of microRNAs during brain development.
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Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.
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Translational control of specific genes during differentiation of HL-60 cells.
Würdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell. 2008 Nov 04; 14(5):382-93.
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.
Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT, Carter BS, Krichevsky AM, Breakefield XO
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008 Dec; 10(12):1470-6.
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM
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De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease.
Patrick E, Rajagopal S, Wong HA, McCabe C, Xu J, Tang A, Imboywa SH, Schneider JA, Pochet N, Krichevsky AM, Chibnik LB, Bennett DA, De Jager PL
Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease. Mol Neurodegener. 2017 07 01; 12(1):51.
Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.
Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008 Sep; 28(17):5369-80.
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.
Teplyuk NM, Mollenhauer B, Gabriely G, Giese A, Kim E, Smolsky M, Kim RY, Saria MG, Pastorino S, Kesari S, Krichevsky AM
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MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity.
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Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway.
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miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget. 2010 Dec; 1(8):710-20.
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.
The Elegance of the MicroRNAs: A Neuronal Perspective. Neuron. 2005 Sep 15; 47(6):779-82.
The Elegance of the MicroRNAs: A Neuronal Perspective.
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Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).
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MicroRNA profiling: from dark matter to white matter, or identifying new players in neurobiology.
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Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.
Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep; 122(9):3063-87.
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.
Context effect: microRNA-10b in cancer cell proliferation, spread and death. Autophagy. 2011 Nov; 7(11):1384-6.
Context effect: microRNA-10b in cancer cell proliferation, spread and death.
Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z
Molecular endocrinology (Baltimore, Md.)
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Developmental regulation of proenkephalin gene expression in osteoblasts.
Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-a-PU.1 pathway. Nat Med. 2011 Jan; 17(1):64-70.
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-a-PU.1 pathway.
O'Connor JF, Birken S, Lustbader JW, Krichevsky A, Chen Y, Canfield RE
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Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements.