Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA
Journal of immunology (Baltimore, Md. : 1950)
Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2018 04 01; 200(7):2505-2506.
Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.
Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH
Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 04 15; 200(8):2592-2602.
Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.
Preventing Antibody-mediated Rejection During Transplantation: The Potential of Tfr Cells. Transplantation. 2018 10; 102(10):1597-1598.
Preventing Antibody-mediated Rejection During Transplantation: The Potential of Tfr Cells.
Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation. Am J Transplant. 2019 01; 19(1):77-88.
DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.
Control of antibody responses in vaccination and allergic inflammation by follicular regulatory T cells
Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R
Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2018 07 12; 3(13).
Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing.
Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS
Proceedings of the National Academy of Sciences of the United States of America
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6.
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Bradner JE, Melnick AM, Blazar BR
Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease. Blood. 2019 01 03; 133(1):94-99.
Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.
Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. JCI Insight. 2018 10 18; 3(20).
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity.
Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8.
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13347-13352.
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
Hou S, Clement RL, Diallo A, Blazar BR, Rudensky AY, Sharpe AH, Sage PT
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. J Exp Med. 2019 03 04; 216(3):605-620.
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.
Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR
Targeting PI3Kd function for amelioration of murine chronic graft-versus-host disease. Am J Transplant. 2019 06; 19(6):1820-1830.
Targeting PI3Kd function for amelioration of murine chronic graft-versus-host disease.
Samuel L. Wasserstrom Professor of Neurology
Denise and David Bunning Professor of Pediatrics in the Field of Allergy and Immunology
Eccleston D, Horrigan M, Rafter T, Holt G, Worthley SG, Sage P, Whelan A, Reid C, Thompson PL
Improving Guideline Compliance in Australia With a National Percutaneous Coronary Intervention Outcomes Registry. Heart Lung Circ. 2017 Dec; 26(12):1303-1309.
Improving Guideline Compliance in Australia With a National Percutaneous Coronary Intervention Outcomes Registry.
Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 10; 20(10):1360-1371.
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.
Current opinion in organ transplantation
Follicular T-cell regulation of alloantibody formation. Curr Opin Organ Transplant. 2020 02; 25(1):22-26.
Follicular T-cell regulation of alloantibody formation.
Shi Q, Carman CV, Chen Y, Sage PT, Xue F, Liang XM, Gilbert GE
Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice. Blood Adv. 2020 05 26; 4(10):2272-2285.
Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice.
Morrissette JA, Pruner K, Lee S, Paster J, Sommer W, O J, Hanekamp I, Sage P, Benichou G, Madsen JC
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts. J Heart Lung Transplant. 2020 Apr; 39(4S):S89.
Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts.
Janssen E, Tohme M, Butts J, Giguere S, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 08 06; 5(15).
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.
Cai S, Choi JY, Borges TJ, Zhang H, Miao J, Ichimura T, Li X, Xu S, Chu P, Eskandari SK, Allos H, Alhaddad JB, Muhsin SA, Yatim K, Riella LV, Sage PT, Chandraker AK, Azzi JR
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo. Sci Rep. 2020 08 28; 10(1):14249.
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med. 2021 01 04; 218(1).
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Turner JA, Stephen-Victor E, Wang S, Rivas MN, Abdel-Gadir A, Harb H, Cui Y, Fanny M, Charbonnier LM, Fong JJH, Benamar M, Wang L, Burton OT, Bansal K, Bry L, Zhu C, Li QZ, Clement RL, Oettgen HC, Crestani E, Rachid R, Sage PT, Chatila TA
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 12 15; 53(6):1202-1214.e6.
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK
T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 12 15; 205(12):3247-3262.
T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.
The multifaceted functions of follicular regulatory T cells. Curr Opin Immunol. 2020 12; 67:68-74.
The multifaceted functions of follicular regulatory T cells.
Transplantation Tolerance: Expanded and Selective Roles for B Cells. Transplantation. 2020 12; 104(12):2459-2460.
Transplantation Tolerance: Expanded and Selective Roles for B Cells.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020 12 23; 183(7):1848-1866.e26.
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Turner JA, Stephen-Victor E, Wang S, Rivas MN, Abdel-Gadir A, Harb H, Cui Y, Fanny M, Charbonnier LM, Hung Fong JJ, Benamar M, Wang L, Burton OT, Bansal K, Bry L, Zhu C, Li QZ, Clement RL, Oettgen HC, Crestani E, Rachid R, Sage PT, Chatila TA
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 Dec 15; 53(6):1331-1332.
Wara AK, Wang S, Wu C, Fang F, Haemmig S, Weber BN, Aydogan CO, Tesmenitsky Y, Aliakbarian H, Hawse JR, Subramaniam M, Zhao L, Sage PT, Tavakkoli A, Garza A, Lynch L, Banks AS, Feinberg MW
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver. Cell Rep. 2020 12 29; 33(13):108550.
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver.
Mohammed MT, Cai S, Hanson BL, Zhang H, Clement RL, Daccache J, Cavazzoni CB, Blazar BR, Alessandrini A, Rennke HG, Chandraker A, Sage PT
Follicular T cells mediate donor-specific antibody and rejection after solid organ transplantation. Am J Transplant. 2021 05; 21(5):1893-1901.
Follicular T cells mediate donor-specific antibody and rejection after solid organ transplantation.
Humoral Immunoregulation of allergic disease by follicular T cell subsets
Control of Humoral and Cellular Immunity to Viral Infections of the Lung by Follicular CD8 T Cells
Guglielmo C, Bin S, Cantarelli C, Hartzell S, Angeletti A, Donadei C, Cumpelik A, Anderson L, Cody E, Sage PT, La Manna G, Fiaccadori E, Heeger PS, Cravedi P
Journal of the American Society of Nephrology : JASN
Erythropoietin Reduces Auto- and Alloantibodies by Inhibiting T Follicular Helper Cell Differentiation. J Am Soc Nephrol. 2021 10; 32(10):2542-2560.
Erythropoietin Reduces Auto- and Alloantibodies by Inhibiting T Follicular Helper Cell Differentiation.
Frontiers in cell and developmental biology
Regulation of Alloantibody Responses. Front Cell Dev Biol. 2021; 9:706171.
Integrated Analysis of SARS-CoV-2 Vaccine Responses During Aging
Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR
Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Front Immunol. 2021; 12:757836.
Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease.
Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305.
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
Borges TJ, Murakami N, Lape IT, Gassen RB, Liu K, Cai S, Daccache J, Safa K, Shimizu T, Ohori S, Paterson AM, Cravedi P, Azzi J, Sage PT, Sharpe AH, Li XC, Riella LV
Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms. JCI Insight. 2021 12 22; 6(24).
Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms.
Methods in molecular biology (Clifton, N.J.)
Tfh-Mediated and Tfr-Suppressed Antigen-Driven IgG and IgE Assays. Methods Mol Biol. 2022; 2380:175-185.
Tfh-Mediated and Tfr-Suppressed Antigen-Driven IgG and IgE Assays.
Jiang L, Yilmaz M, Uehara M, Cavazzoni CB, Kasinath V, Zhao J, Naini SM, Li X, Banouni N, Fiorina P, Shin SR, Tullius SG, Bromberg JS, Sage PT, Abdi R
Characterization of Leptin Receptor+ Stromal Cells in Lymph Node. Front Immunol. 2021; 12:730438.
Characterization of Leptin Receptor+ Stromal Cells in Lymph Node.
Cavazzoni CB, Hanson BL, Podestà MA, Bechu ED, Clement RL, Zhang H, Daccache J, Reyes-Robles T, Hett EC, Vora KA, Fadeyi OO, Oslund RC, Hazuda DJ, Sage PT
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice. Cell Rep. 2022 02 22; 38(8):110399.
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice.
Gassen RB, Borges TJ, Pérez-Sáez MJ, Zhang H, Al Jurdi A, Llinàs-Mallol L, Aoyama B, Lima M, Pascual J, Sage PT, Murakami N, Riella LV
T cell depletion increases humoral response by favoring T follicular helper cells expansion. Am J Transplant. 2022 07; 22(7):1766-1778.
T cell depletion increases humoral response by favoring T follicular helper cells expansion.
Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Luznik L, Maillard I, Hill GR, MacDonald KPA, Munn DH, Serody JS, Murphy WJ, Kean LS, Zhang Y, Bradner JE, Qi J, Blazar BR
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood. 2022 05 12; 139(19):2983-2997.
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.
Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, Barone F, Giannini S, Bahmani B, Sage PT, Patsopoulos NA, Tsokos GC, Bromberg JS, Hoffmeister K, Jiang L, Abdi R
Characterization of CD41+ cells in the lymph node. Front Immunol. 2022; 13:801945.
Characterization of CD41+ cells in the lymph node.
Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets? Curr Opin Organ Transplant. 2022 10 01; 27(5):371-375.
Role of T follicular helper and T follicular regulatory cells in antibody-mediated rejection: new therapeutic targets?
Zhang H, Cavazzoni CB, Hanson BL, Bechu ED, Podestà MA, Azzi J, Blazar BR, Chong AS, Kreisel D, Alessandrini A, Sage PT
Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation. Transplantation. 2023 02 01; 107(2):e47-e57.
Transcriptionally Distinct B Cells Infiltrate Allografts After Kidney Transplantation.
Check(point) yourself before you wreck yourself in tumors. Nat Immunol. 2023 01; 24(1):10-11.
Check(point) yourself before you wreck yourself in tumors.
Zhao J, Jung S, Li X, Li L, Kasinath V, Zhang H, Movahedi SN, Mardini A, Sabiu G, Hwang Y, Saxena V, Song Y, Ma B, Acton SE, Kim P, Madsen JC, Sage PT, Tullius SG, Tsokos GC, Bromberg JS, Abdi R
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice. J Clin Invest. 2022 12 15; 132(24).
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice.
Eccleston DS, Chowdhury E, Rafter T, Sage P, Whelan A, Reid C, Liew D, Duong M, Schwarz N, Worthley SG
Long-Term Outcomes of Contemporary Percutaneous Coronary Intervention with the Xience Drug-Eluting Stent: Results from a Multicentre Australian Registry. J Clin Med. 2022 Dec 29; 12(1).
Long-Term Outcomes of Contemporary Percutaneous Coronary Intervention with the Xience Drug-Eluting Stent: Results from a Multicentre Australian Registry.
Julé AM, Lam KP, Taylor M, Hoyt KJ, Wei K, Gutierrez-Arcelus M, Case SM, Chandler M, Chang MH, Cohen EM, Dedeoglu F, Halyabar O, Hausmann J, Hazen MM, Janssen E, Lo J, Lo MS, Meidan E, Roberts JE, Wobma H, Son MBF, Sundel RP, Lee PY, Sage PT, Chatila TA, Nigrovic PA, Rao DA, Henderson LA
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. Front Immunol. 2022; 13:1068399.
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis.
Durgam SS, Khiew SHW, Sayin I, Jain D, Yin D, Cavazzoni CB, Sage PT, King RG, Chong AS
MHC Tetramers Specifically Identify High- and Low-avidity Donor-specific B Cells in Transplantation Tolerance and Rejection. Transplantation. 2023 12 01; 107(12):2526-2532.
MHC Tetramers Specifically Identify High- and Low-avidity Donor-specific B Cells in Transplantation Tolerance and Rejection.
Guinn MT, Szuter ES, Yokose T, Ge J, Rosales IA, Chetal K, Sadreyev RI, Cuenca AG, Kreisel D, Sage PT, Russell PS, Madsen JC, Colvin RB, Alessandrini A
Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics. Am J Transplant. 2023 09; 23(9):1319-1330.
Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics.
Iske J, Dedeilia A, Xiao Y, Martin F, Emmert MY, Sage PT, Abdi R, Zhou H, Tullius SG
The Impact of T-cell Aging on Alloimmunity and Inflammaging. Transplantation. 2024 03 01; 108(3):634-642.
The Impact of T-cell Aging on Alloimmunity and Inflammaging.
Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG
Transplanting old organs promotes senescence in young recipients. Am J Transplant. 2024 Mar; 24(3):391-405.
Transplanting old organs promotes senescence in young recipients.
Zhang H, Cavazzoni CB, Podestà MA, Bechu ED, Ralli G, Chandrakar P, Lee JM, Sayin I, Tullius SG, Abdi R, Chong AS, Blazar BR, Sage PT
IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts. JCI Insight. 2023 10 23; 8(20).
IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts.
Podestà MA, Cavazzoni CB, Hanson BL, Bechu ED, Ralli G, Clement RL, Zhang H, Chandrakar P, Lee JM, Reyes-Robles T, Abdi R, Diallo A, Sen DR, Sage PT
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states. Nat Commun. 2023 11 24; 14(1):7712.
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states.
Surendar J, Hackenberg RK, Schmitt-Sánchez F, Ossendorff R, Welle K, Stoffel-Wagner B, Sage PT, Burger C, Wirtz DC, Strauss AC, Schildberg FA
Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion. Front Immunol. 2024; 15:1396592.
Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion.
Bortolin RH, Nawar F, Park C, Trembley MA, Prondzynski M, Sweat ME, Wang P, Chen J, Lu F, Liou C, Berkson P, Keating EM, Yoshinaga D, Pavlaki N, Samenuk T, Cavazzoni CB, Sage PT, Ma Q, Whitehill RD, Abrams DJ, Carreon CK, Putra J, Alexandrescu S, Guo S, Tsai WC, Rubart M, Kubli DA, Mullick AE, Bezzerides VJ, Pu WT
Antisense Oligonucleotide Therapy for Calmodulinopathy. Circulation. 2024 Oct 08; 150(15):1199-1210.
Antisense Oligonucleotide Therapy for Calmodulinopathy.
TFH cell responses endure in human lymph nodes after vaccination. Nat Immunol. 2024 Sep; 25(9):1510-1512.
TFH cell responses endure in human lymph nodes after vaccination.
Skin in the game - locally made antibodies fight resident bacteria. Nature. 2025 Feb; 638(8052):894-896.
Skin in the game - locally made antibodies fight resident bacteria.
Nelson CS, Podestà MA, Gempler MG, Lee JM, Batty CJ, Mathenge PG, Sainju A, Chang MR, Ke H, Chandrakar P, Bechu E, Richardson S, Cavazzoni CB, Tullius SG, Abdi R, Ghebremichael M, Haigis MC, Marasco WA, Sage PT
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation. JCI Insight. 2025 Apr 22; 10(8).
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation.
Chandrakar P, Nelson CS, Podestà MA, Cavazzoni CB, Gempler M, Lee JM, Richardson S, Zhang H, Samarpita S, Ciofani M, Chatila T, Kuchroo VK, Sage PT
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses. Nat Immunol. 2025 Mar; 26(3):473-483.
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses.
Sasaki T, Sowerby J, Xiao Y, Wang R, Samarpita S, Abe T, Marks KE, Horisberger A, Gao Y, Lee PY, Qu Y, Sze MA, Alves SE, Levesque MC, Fujio K, Costenbader KH, Sage PT, Rao DA
bioRxiv : the preprint server for biology
Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus. bioRxiv. 2025 Aug 30.
Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus.
Zaiken MC, Jin S, McDonald-Hyman CS, Hartigan CR, Sage PT, Hippen KL, Koehn BH, Panoskaltsis-Mortari A, Riddle MJ, Eide CR, Tolar J, Hill GR, Luznik L, Cutler CS, Ritz JR, Kean LS, Tsagaratou A, Rao A, Blazar BR
Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD. Blood. 2025 Jun 12; 145(24):2813-2827.
Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD.
Zhang H, Podestà MA, Cavazzoni CB, Wu Y, Lee JM, Li X, Raeder PL, Chandrakar P, Gempler M, Richardson S, Ghosh D, Sayin I, Blazar BR, Abdi R, Weins A, Chong AS, Sage PT
Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells. Nat Commun. 2025 Mar 04; 16(1):2151.
Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells.
Zhang H, Sabiu G, Jung S, Podestà MA, Zhao J, Gempler M, Yamamura M, Miao J, Tsokos GC, Karadagi A, Kawai T, Abdi R, Sage PT
Targeted delivery of IL-21 neutralizing nanotherapeutics to lymph nodes and kidney allografts attenuates B cell alloimmunity. Kidney Int. 2025 Jul; 108(1):48-56.
Targeted delivery of IL-21 neutralizing nanotherapeutics to lymph nodes and kidney allografts attenuates B cell alloimmunity.
Li W, Terada Y, Bai YZ, Yokoyama Y, Shepherd HM, Amrute JM, Bery AI, Liu Z, Gauthier JM, Terekhova M, Bharat A, Ritter JH, Puri V, Hachem RR, Turnquist HR, Sage PT, Alessandrini A, Artyomov MN, Lavine KJ, Nava RG, Krupnick AS, Gelman AE, Kreisel D
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice. J Clin Invest. 2025 May 15; 135(10).
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice.
Hayashi K, Yokose T, Lancey J, Szuter ES, Kwon B, Murillo F, Giarraputo A, Rosales I, Li W, Guinn MT, Cosimi G, Odutola SR, Kim J, Sage PT, Tarantino G, Huang A, Liu D, Effiom D, Boland GM, Cohen S, McCallion O, Issa F, Jordan C, Luo X, Liss AS, Ruddy DA, Piquet M, Russell PS, Colvin RB, Madsen JC, Cosimi AB, Kreisel D, Alessandrini A
Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance. Res Sq. 2025 Aug 18.
Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance.
Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus. Res Sq. 2025 Sep 12.
Giff AE, Wruble Clark M, Bhattacharyya S, Sage PT, Madore B, Guenette JP, Miyawaki EK
Deep cervical lymph node analysis in central nervous system inflammatory disease. Front Immunol. 2026; 17:1747114.
Deep cervical lymph node analysis in central nervous system inflammatory disease.
Basu J, Nikoletou D, Miles C, MacLachlan H, Parry-Williams G, Tilby-Jones F, Bulleros P, Fanton Z, Baker C, Purcell S, Lech C, Chapman T, Sage P, Wahid S, Sheikh N, Jayakumar S, Malhotra A, Keteepe-Arachi T, Gray B, Finocchiaro G, Carr-White G, Behr E, Tome M, O'Driscoll J, Chis Ster I, Sharma S, Papadakis M
High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial. Eur Heart J. 2025 May 14; 46(19):1803-1815.
High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial.
Andrade MS, Hynes GE, Suran ZR, Yin D, Alegre ML, Sage PT, Chong AS
Resolving ScRNA-Seq Signatures of Antigen-Specific CD4+ T Cells in Tolerance across Semi-Allogeneic Transplantation and Pregnancy. bioRxiv. 2025 Oct 23.
Resolving ScRNA-Seq Signatures of Antigen-Specific CD4+ T Cells in Tolerance across Semi-Allogeneic Transplantation and Pregnancy.
Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2025 10 08; 10(20).
Lee JM, Raeder PL, Rashid RB, Zhang H, Nelson CS, Richardson SG, Burke KP, Chandrakar P, Podestà MA, Gempler MG, Batty C, Kong D, Gavzy SJ, Shirkey MW, Yang C, Bromberg JS, Haigis MC, Marasco WA, Sharpe AH, Sage PT
Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs. Nat Immunol. 2026 Feb; 27(2):336-347.
Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs.
The authors reply. Kidney Int. 2025 Dec; 108(6):1190.
Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul; 2(7):643-54.
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.
Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH
Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest. 2014 Dec; 124(12):5191-204.
Circulating T follicular regulatory and helper cells have memory-like properties.
Sage PT, Paterson AM, Lovitch SB, Sharpe AH
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014 Dec 18; 41(6):1026-39.
The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.
Wang N, Halibozek PJ, Yigit B, Zhao H, O'Keeffe MS, Sage P, Sharpe A, Terhorst C
Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Front Immunol. 2015; 6:158.
Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors.
In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods Mol Biol. 2015; 1291:151-60.
In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses.
Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.
T follicular regulatory cells in the regulation of B cell responses. Trends Immunol. 2015 Jul; 36(7):410-8.
T follicular regulatory cells in the regulation of B cell responses.
Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH
Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015 Jul 14; 12(2):163-71.
Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.
Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21.
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
T follicular regulatory cells. Immunol Rev. 2016 May; 271(1):246-59.
Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC
Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17.
Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.
Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446.
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.
Kouroukis CT, Crump M, MacDonald D, Larouche JF, Stewart DA, Johnston J, Sauvageau S, Beausoleil E, Sage P, Dubois SG, Christofides A, Di Clemente S, Sehn L
An open-label expanded-access trial of bendamustine in patients with rituximab-refractory indolent non-Hodgkin lymphoma or previously untreated chronic lymphocytic leukemia: BEND-ACT. Curr Oncol. 2015 Aug; 22(4):260-71.
An open-label expanded-access trial of bendamustine in patients with rituximab-refractory indolent non-Hodgkin lymphoma or previously untreated chronic lymphocytic leukemia: BEND-ACT.
Jin Y, Chauhan SK, El Annan J, Annan JE, Sage PT, Sharpe AH, Dana R
A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011 04; 178(4):1922-9.
A novel function for programmed death ligand-1 regulation of angiogenesis.
Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA
Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97.
Transcellular diapedesis is initiated by invasive podosomes.
Renal Division/Transplant Research Center, LM301a
Frontiers in bioscience (Landmark edition)
Settings and mechanisms for trans-cellular diapedesis. Front Biosci (Landmark Ed). 2009 06 01; 14(13):5066-83.
Settings and mechanisms for trans-cellular diapedesis.
Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65.
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012 Apr 15; 188(8):3686-99.
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.
Sage PT, Francisco LM, Carman CV, Sharpe AH
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol. 2013 Feb; 14(2):152-61.
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2017 12 15; 199(12):3972-3980.
B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.
Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N
Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40.
Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts.
The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul; 236:219-42.
The PD-1 pathway in tolerance and autoimmunity.