LLM1LanceMunnLance Leon Munn, Ph.D.42.36241700000000-71.0689370000000045163Munn, LanceLeon617/726-4083Associate Professor of Radiation Oncologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10655092Jain RK, Munn LLNature medicineLeaky vessels? Call Ang1! Nat Med. 2000 Feb; 6(2):131-2.Nat Med2000-02-01T00:00:002000Leaky vessels? Call Ang1!12460895Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LLCancer researchCationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 2002 Dec 01; 62(23):6831-6.Cancer Res2002-12-01T00:00:002002Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.Authorship 1052295529367467Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TPJCI insightLymphatic function measurements influenced by contrast agent volume and body position. JCI Insight. 2018 01 25; 3(2).JCI Insight2018-01-25T00:00:002018Lymphatic function measurements influenced by contrast agent volume and body position.8243206Teague TK, Munn L, Zygourakis K, McIntyre BWCytometryAnalysis of lymphocyte activation and proliferation by video microscopy and digital imaging. Cytometry. 1993 Oct; 14(7):772-82.Cytometry1993-10-01T00:00:001993Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging.Authorship 10560922Authorship 1056365229606306Stylianopoulos T, Munn LL, Jain RKTrends in cancerReengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends Cancer. 2018 04; 4(4):258-259.Trends Cancer2018-03-17T00:00:002018Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.29606314Stylianopoulos T, Munn LL, Jain RKTrends in cancerReengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends Cancer. 2018 04; 4(4):292-319.Trends Cancer2018-03-13T00:00:002018Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.12001988Jain RK, Munn LL, Fukumura DNature reviews. CancerDissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer. 2002 Apr; 2(4):266-76.Nat Rev Cancer2002-04-01T00:00:002002Dissecting tumour pathophysiology using intravital microscopy.Authorship 1058236529674756Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RKNature protocolsQuantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 05; 13(5):1091-1105.Nat Protoc2018-04-19T00:00:002018Quantifying solid stress and elastic energy from excised or in situ tumors.21224417Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaScaling rules for diffusive drug delivery in tumor and normal tissues. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1799-803.Proc Natl Acad Sci U S A2011-01-11T00:00:002011Scaling rules for diffusive drug delivery in tumor and normal tissues.21742796Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RKPhysiological reviewsNormalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121.Physiol Rev2011-07-01T00:00:002011Normalization of the vasculature for treatment of cancer and other diseases.23209146Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsLiver tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12).Cold Spring Harb Protoc2012-12-01T00:00:002012Liver tumor preparation in mice.Authorship 1043183Authorship 10656485429766399Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AWAngiogenesisConsensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532.Angiogenesis2018-08-01T00:00:002018Consensus guidelines for the use and interpretation of angiogenesis assays.20374484Fukumura D, Duda DG, Munn LL, Jain RKMicrocirculation (New York, N.Y. : 1994)Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010 Apr; 17(3):206-25.Microcirculation2010-04-01T00:00:002010Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.14500342Forbes NS, Munn LL, Fukumura D, Jain RKCancer researchSparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 2003 Sep 01; 63(17):5188-93.Cancer Res2003-09-01T00:00:002003Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.22065738Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TPProceedings of the National Academy of Sciences of the United States of AmericaImpaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9.Proc Natl Acad Sci U S A2011-11-07T00:00:002011Impaired lymphatic contraction associated with immunosuppression.22753607Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsRabbit ear chambers. Cold Spring Harb Protoc. 2012 Jul 01; 2012(7):813-14.Cold Spring Harb Protoc2012-07-01T00:00:002012Rabbit ear chambers.10684732Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JMMicrovascular researchEffect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc Res. 2000 Mar; 59(2):265-77.Microvasc Res2000-03-01T00:00:002000Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.11254400Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LLMicrovascular researchKinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvasc Res. 2001 Mar; 61(2):203-10.Microvasc Res2001-03-01T00:00:002001Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.Authorship 107393220501615Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura DClinical cancer research : an official journal of the American Association for Cancer ResearchAngiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res. 2010 Jul 15; 16(14):3618-27.Clin Cancer Res2010-05-25T00:00:002010Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.7948702Munn LL, Melder RJ, Jain RKBiophysical journalAnalysis of cell flux in the parallel plate flow chamber: implications for cell capture studies. Biophys J. 1994 Aug; 67(2):889-95.Biophys J1994-08-01T00:00:001994Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.18323810Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DGNature protocolsA protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents. Nat Protoc. 2008; 3(3):388-97.Nat Protoc2008-01-01T00:00:002008A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.23209145Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsPancreatic tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12).Cold Spring Harb Protoc2012-12-01T00:00:002012Pancreatic tumor preparation in mice.23547161Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMeasuring angiogenesis and hemodynamics in mice. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):354-8.Cold Spring Harb Protoc2013-04-01T00:00:002013Measuring angiogenesis and hemodynamics in mice.Authorship 114853218188702Munn LL, Dupin MMAnnals of biomedical engineeringBlood cell interactions and segregation in flow. Ann Biomed Eng. 2008 Apr; 36(4):534-44.Ann Biomed Eng2008-01-11T00:00:002008Blood cell interactions and segregation in flow.19477947Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RKThe American journal of pathologyParadoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. Am J Pathol. 2009 Jul; 175(1):294-302.Am J Pathol2009-05-28T00:00:002009Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.19332720Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RKJournal of clinical oncology : official journal of the American Society of Clinical OncologyEdema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol. 2009 May 20; 27(15):2542-52.J Clin Oncol2009-03-30T00:00:002009Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.8228280Munn LL, Glacken MW, McIntyre BW, Zygourakis KJournal of immunological methodsAnalysis of lymphocyte aggregation using digital image analysis. J Immunol Methods. 1993 Nov 05; 166(1):11-25.J Immunol Methods1993-11-05T00:00:001993Analysis of lymphocyte aggregation using digital image analysis.20581828Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LLNature methodsSimultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nat Methods. 2010 Aug; 7(8):655-60.Nat Methods2010-06-27T00:00:002010Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.21081058Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RKBiophysical journalDiffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophys J. 2010 Nov 17; 99(10):3119-28.Biophys J2010-11-17T00:00:002010Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.Authorship 10743621835951Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LLBloodEngineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Blood. 2011 Oct 27; 118(17):4740-9.Blood2011-08-11T00:00:002011Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.10666365McDonald DM, Munn L, Jain RKThe American journal of pathologyVasculogenic mimicry: how convincing, how novel, and how significant? Am J Pathol. 2000 Feb; 156(2):383-8.Am J Pathol2000-02-01T00:00:002000Vasculogenic mimicry: how convincing, how novel, and how significant?12947016Friedrich EB, Tager AM, Liu E, Pettersson A, Owman C, Munn L, Luster AD, Gerszten REArteriosclerosis, thrombosis, and vascular biologyMechanisms of leukotriene B4--triggered monocyte adhesion. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1761-7.Arterioscler Thromb Vasc Biol2003-08-28T00:00:002003Mechanisms of leukotriene B4--triggered monocyte adhesion.19768109Jain A, Munn LLPloS oneDeterminants of leukocyte margination in rectangular microchannels. PLoS One. 2009 Sep 21; 4(9):e7104.PLoS One2009-09-21T00:00:002009Determinants of leukocyte margination in rectangular microchannels.22673771Song JW, Bazou D, Munn LLIntegrative biology : quantitative biosciences from nano to macroAnastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis. Integr Biol (Camb). 2012 Aug; 4(8):857-62.Integr Biol (Camb)2012-06-06T00:00:002012Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.23028075Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMammary fat pad chamber preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1113-4.Cold Spring Harb Protoc2012-10-01T00:00:002012Mammary fat pad chamber preparation in mice.23118365Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsLymphangiography of the mouse ear. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1179-80.Cold Spring Harb Protoc2012-11-01T00:00:002012Lymphangiography of the mouse ear.15607960Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RKCancer cellKinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63.Cancer Cell2004-12-01T00:00:002004Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.17363594Jain RK, Tong RT, Munn LLCancer researchEffect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res. 2007 Mar 15; 67(6):2729-35.Cancer Res2007-03-15T00:00:002007Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.Authorship 1124507230630829Nia HT, Munn LL, Jain RKClinical cancer research : an official journal of the American Association for Cancer ResearchMapping Physical Tumor Microenvironment and Drug Delivery. Clin Cancer Res. 2019 04 01; 25(7):2024-2026.Clin Cancer Res2019-01-10T00:00:002019Mapping Physical Tumor Microenvironment and Drug Delivery.Authorship 1129424630700544Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaExperimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2662-2671.Proc Natl Acad Sci U S A2019-01-30T00:00:002019Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.D009389Disorders87426400.45915Neovascularization, PathologicD013314Phenomena64116830.657836Stress, Mechanical30948807Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RKNature biomedical engineeringSolid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245.Nat Biomed Eng2019-01-07T00:00:002019Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.Authorship 114121423D008208Anatomy1452560.856242Lymphatic SystemAuthorship 1220312D008954Concepts & IdeasDevices344596260.299304Models, BiologicalD042601Anatomy1703520.70911Lymphatic VesselsRadiation OncologyRadiologySurgeryPlastic SurgeryBeth Israel Deaconess Medical CenterBoston Children's HospitalMassachusetts General HospitalMassachusetts Institute of TechnologyDGD3Gabriel DanDudaGabriel Dan Duda, D.M.D., Ph.D.42.37730000000000-71.0525000000000076504Duda, Gabriel DanProfessor of Radiation OncologyDEI1DonIngberDon Ingber, M.D.,Ph.D.42.33773240000000-71.1051962000000029942Ingber, DonJudah Folkman Professor of Vascular Biology in the Department of SurgeryGCS2GregorySharpGregory C. Sharp, Ph.D.42.36241700000000-71.0689370000000022015Sharp, GregoryAssociate Professor of Radiation OncologyYW82YiWangYi Wang, Ph.D.42.36241700000000-71.0689370000000019687Wang, YiAssistant Professor of Radiation OncologyBMC6BenjaminClasieBenjamin Micheal Patrick Clasie, Ph.D.42.36241700000000-71.0689370000000025647Clasie, BenjaminAssistant Professor of Radiation OncologyDF7DaiFukumuraDai Fukumura, M.D., Ph.D.42.36389900000000-71.0677780000000032521Fukumura, DaiAssociate Professor of Radiation OncologyDS37DhruvSinghalDhruv Singhal, M.D.42.33510370000000-71.1061649000000064077Singhal, DhruvAssociate Professor of SurgeryYB1YvesBoucherYves Boucher, Ph.D.42.36241700000000-71.0689370000000021554Boucher, YvesCorresponding Member of the Faculty of Radiation OncologyTPP1TimothyPaderaTimothy P. Padera, Ph.D.42.36389900000000-71.0677780000000023800Padera, TimothyAssociate Professor of Radiation OncologyRSL4RobertLangerRobert S. Langer, Sc.D.42.36053900000000-71.0900740000000026380Langer, RobertSenior Lecturer on Surgery, Part-timeRW4RalphWeisslederRalph Weissleder, M.D., Ph.D.42.36125700000000-71.0655270000000048432Weissleder, RalphThrall Family Professor of Radiology11165selected publications3.28150.00241895512research areas11.88910.013411474coauthor of152.18514.582460similar toRKJ1RakeshJainRakesh K. Jain, Ph.D.42.36389900000000-71.0677780000000081300Jain, RakeshA. Werk Cook Professor of Radiation Oncology (Tumor Biology)BW38BrianWineyBrian Winey, Ph.D.42.36241700000000-71.0689370000000082372Winey, BrianAssociate Professor of Radiation OncologyAuthorship 1167341531256115Moran H, Cancel LM, Mayer MA, Qazi H, Munn LL, Tarbell JMBiorheologyThe cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis. Biorheology. 2019; 56(2-3):151-161.Biorheology2019-01-01T00:00:002019The cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.Authorship 1174532631337769Li H, Mei Y, Maimon N, Padera TP, Baish JW, Munn LLScientific reportsThe effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations. Sci Rep. 2019 07 23; 9(1):10649.Sci Rep2019-07-23T00:00:002019The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.Authorship 1179066131395771Munn LL, Jain RKScience (New York, N.Y.)Vascular regulation of antitumor immunity. Science. 2019 Aug 09; 365(6453):544-545.Science2019-08-09T00:00:002019Vascular regulation of antitumor immunity.Authorship 1559091Authorship 1525449Authorship 1076013MN240MohammadrezaNikmaneshiMohammadreza Nikmaneshi, Ph.D.184952Nikmaneshi, MohammadrezaResearch Fellow in Radiation OncologyAuthorship 1196758131619566Munn LL, Nia HTProceedings of the National Academy of Sciences of the United States of AmericaMechanosensing tensile solid stresses. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):21960-21962.Proc Natl Acad Sci U S A2019-10-16T00:00:002019Mechanosensing tensile solid stresses.true1Assistant Professor of Radiation OncologyAssistant Professor of Radiation Oncologytrue1Associate Professor of Radiation OncologyAssociate Professor of Radiation Oncologytrue1Associate Professor of Radiation OncologyAssociate Professor of Radiation Oncologytrue1Assistant Professor of Radiation OncologyAssistant Professor of Radiation Oncologytrue1Associate Professor of Radiation OncologyAssociate Professor of Radiation Oncologytrue1Associate Professor of SurgeryAssociate Professor of SurgeryAuthorship 1223950532015113Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaCombining microenvironment normalization strategies to improve cancer immunotherapy. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3728-3737.Proc Natl Acad Sci U S A2020-02-03T00:00:002020Combining microenvironment normalization strategies to improve cancer immunotherapy.Authorship 1227783432080250Nikmaneshi MR, Firoozabadi B, Mozafari A, Munn LLScientific reportsA multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth. Sci Rep. 2020 02 20; 10(1):3025.Sci Rep2020-02-20T00:00:002020A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth.Authorship 1706612Authorship 18618711Authorship 1252800332501531Nikmaneshi MR, Firoozabadi B, Munn LLBiotechnology and bioengineeringA mechanobiological mathematical model of liver metabolism. Biotechnol Bioeng. 2020 09; 117(9):2861-2874.Biotechnol Bioeng2020-06-30T00:00:002020A mechanobiological mathematical model of liver metabolism.Authorship 1419603Authorship 1334823Authorship 1412754Authorship 1267922832681151Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RKNature protocolsIn vivo compression and imaging in mouse brain to measure the effects of solid stress. Nat Protoc. 2020 08; 15(8):2321-2340.Nat Protoc2020-07-17T00:00:002020In vivo compression and imaging in mouse brain to measure the effects of solid stress.Authorship 1613521Authorship 2014482Authorship 1875254Authorship 1284045932908974Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RKResearch squareIn silico dynamics of COVID-19 phenotypes for optimizing clinical management. Res Sq. 2020 Sep 03.Res Sq2020-09-03T00:00:002020In silico dynamics of COVID-19 phenotypes for optimizing clinical management.Authorship 1299282233122355Nia HT, Munn LL, Jain RKScience (New York, N.Y.)Physical traits of cancer. Science. 2020 10 30; 370(6516).Science2020-10-30T00:00:002020Physical traits of cancer.Authorship 13027752133234602Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, Hato T, Ramjiawan RR, Staiculescu D, Zopf D, Fiebig L, Hobbs GS, Quaas A, Dima S, Popescu I, Huang P, Munn LL, Cobbold M, Goyal L, Zhu AX, Jain RK, Duda DGJournal for immunotherapy of cancerRegorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. J Immunother Cancer. 2020 11; 8(2).J Immunother Cancer2020-11-01T00:00:002020Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.33402434Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaIn silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proc Natl Acad Sci U S A. 2021 01 19; 118(3).Proc Natl Acad Sci U S A2021-01-19T00:00:002021In silico dynamics of COVID-19 phenotypes for optimizing clinical management.Authorship 13174119Authorship 13224082833431577Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DGGutPlacental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2022 01; 71(1):185-193.Gut2021-01-11T00:00:002021Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.Authorship 1335998133648989Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RKClinical cancer research : an official journal of the American Association for Cancer ResearchVascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer. Clin Cancer Res. 2021 05 15; 27(10):2706-2711.Clin Cancer Res2021-03-01T00:00:002021Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer.Authorship 1600791Authorship 1355314934021235Subudhi S, Verma A, Patel AB, Hardin CC, Khandekar MJ, Lee H, McEvoy D, Stylianopoulos T, Munn LL, Dutta S, Jain RKNPJ digital medicineComparing machine learning algorithms for predicting ICU admission and mortality in COVID-19. NPJ Digit Med. 2021 May 21; 4(1):87.NPJ Digit Med2021-05-21T00:00:002021Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19.2026-06-30DUDA, DAN GABRIEL;MUNN, LANCE L2021-07-01Vascularized tumor explants for drug testingR01CA247441Principal Investigatortrue1Associate Professor of Radiation OncologyAssociate Professor of Radiation Oncology2023-09-14MUNN, LANCE L2021-09-15Multiplexed device for rapid coagulopathy testingR21EB031982Principal Investigator2026-08-31JAIN, RAKESH K.;MUNN, LANCE L2021-09-22Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistanceU01CA261842Principal InvestigatorAuthorship 218797Authorship 147857535033853Subudhi S, Voutouri C, Hardin CC, Nikmaneshi MR, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Jain RK, Munn LLEBioMedicineStrategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling. EBioMedicine. 2022 Jan; 75:103809.EBioMedicine2022-01-13T00:00:002022Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling.Authorship 14267181135106474Moran H, Cancel LM, Huang P, Roberge S, Xu T, Tarbell JM, Munn LLMatrix biology plusGlycocalyx mechanotransduction mechanisms are involved in renal cancer metastasis. Matrix Biol Plus. 2022 Feb; 13:100100.Matrix Biol Plus2022-01-06T00:00:002022Glycocalyx mechanotransduction mechanisms are involved in renal cancer metastasis.Authorship 21474312Authorship 14297877Authorship 14382123Authorship 1439827835318426Baish JW, Padera TP, Munn LLScientific reportsThe effects of gravity and compression on interstitial fluid transport in the lower limb. Sci Rep. 2022 03 22; 12(1):4890.Sci Rep2022-03-22T00:00:002022The effects of gravity and compression on interstitial fluid transport in the lower limb.35198957Souri M, Soltani M, Moradi Kashkooli F, Kiani Shahvandi M, Chiani M, Shariati FS, Mehrabi MR, Munn LLMaterials today. BioTowards principled design of cancer nanomedicine to accelerate clinical translation. Mater Today Bio. 2022 Jan; 13:100208.Mater Today Bio2022-02-01T00:00:002022Towards principled design of cancer nanomedicine to accelerate clinical translation.Authorship 2910357Authorship 341222Authorship 3427635Authorship 1515537836623200Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaMechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023 01 17; 120(3):e2211132120.Proc Natl Acad Sci U S A2023-01-09T00:00:002023Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2.Authorship 1521363536712369Li H, Wei H, Padera TP, Baish JW, Munn LLPNAS nexusComputational simulations of the effects of gravity on lymphatic transport. PNAS Nexus. 2022 Nov; 1(5):pgac237.PNAS Nexus2022-10-18T00:00:002022Computational simulations of the effects of gravity on lymphatic transport.Authorship 152497914Authorship 15232481636831366Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DGCancersInhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models. Cancers (Basel). 2023 Feb 06; 15(4).Cancers (Basel)2023-02-06T00:00:002023Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models.36747853Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Bardeesy N, Ho WJ, Jain RK, Duda DGbioRxiv : the preprint server for biologyReprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. bioRxiv. 2023 Jan 27.bioRxiv2023-01-27T00:00:002023Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.Authorship 484373true1Corresponding Member of the Faculty of Radiation OncologyCorresponding Member of the Faculty of Radiation OncologyAuthorship 15681565Authorship 15650411Authorship 15551958Authorship 1555272337163659Wang X, Shen Y, Shang M, Liu X, Munn LLCardiovascular researchEndothelial mechanobiology in atherosclerosis. Cardiovasc Res. 2023 07 06; 119(8):1656-1675.Cardiovasc Res2023-07-06T00:00:002023Endothelial mechanobiology in atherosclerosis.37289729Nikmaneshi MR, Jain RK, Munn LLPLoS computational biologyComputational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization. PLoS Comput Biol. 2023 Jun; 19(6):e1011131.PLoS Comput Biol2023-06-08T00:00:002023Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.37202621Munn LL, Bazou DMethods in molecular biology (Clifton, N.J.)A Self-Assembly Method for Creating Vascularized Tumor Explants Using Biomaterials for 3D Culture. Methods Mol Biol. 2023; 2645:211-220.Methods Mol Biol2023-01-01T00:00:002023A Self-Assembly Method for Creating Vascularized Tumor Explants Using Biomaterials for 3D Culture.37461473Razavi MS, Lei PJ, Amoozgar Z, Leartprapun N, Nadkarni SK, Baish JW, Padera TP, Munn LLResearch squareRegeneration of collecting lymphatic vessels following injury. Res Sq. 2023 Jul 03.Res Sq2023-07-03T00:00:002023Regeneration of collecting lymphatic vessels following injury.Authorship 3256922Authorship 15948441437781599Zhou H, Baish JW, O'Melia MJ, Darragh LB, Specht E, Czapla J, Lei PJ, Menzel L, Rajotte JJ, Nikmaneshi MR, Razavi MS, Vander Heiden MG, Ubellacker JM, Munn LL, Boland GM, Cohen S, Karam SD, Padera TPbioRxiv : the preprint server for biologyCancer immunotherapy responses persist after lymph node resection. bioRxiv. 2024 Mar 01.bioRxiv2024-03-01T00:00:002024Cancer immunotherapy responses persist after lymph node resection.Authorship 4000232true1Research Fellow in Radiation OncologyResearch Fellow in Radiation Oncologytrue1A. Werk Cook Professor of Radiation Oncology (Tumor Biology)A. Werk Cook Professor of Radiation Oncology (Tumor Biology)true1Thrall Family Professor of RadiologyThrall Family Professor of Radiologytrue1Senior Lecturer on Surgery, Part-timeSenior Lecturer on Surgery, Part-timetrue1Associate Professor of Radiation OncologyAssociate Professor of Radiation OncologyAuthorship 161132118Authorship 1609539538014141Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Arroyo-Ataz G, Razavi MS, Zhou H, Menzel L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Ubellacker JM, Jones D, Padera TPbioRxiv : the preprint server for biologyLymphatic muscle cells are unique cells that undergo aging induced changes. bioRxiv. 2023 Nov 19.bioRxiv2023-11-19T00:00:002023Lymphatic muscle cells are unique cells that undergo aging induced changes.37949675Nikmaneshi MR, Baish JW, Zhou H, Padera TP, Munn LLAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis. Adv Sci (Weinh). 2023 Dec; 10(36):e2304076.Adv Sci (Weinh)2023-11-10T00:00:002023Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.Authorship 1615032938076985Jain R, Hadjigeorgiou A, Harkos C, Mishra A, Morad G, Johnson S, Ajami N, Wargo J, Munn L, Stylianopoulos TResearch squareDissecting the Impact of the Gut Microbiome on Cancer Immunotherapy. Res Sq. 2023 Nov 30.Res Sq2023-11-30T00:00:002023Dissecting the Impact of the Gut Microbiome on Cancer Immunotherapy.2028-06-30PADERA, TIMOTHY P2023-07-01Systems Biology of Antigen and T-Cell Transport in Cancer ImmunotherapyR01CA284603Co-Principal Investigatortrue1Professor of Radiation OncologyProfessor of Radiation OncologyAuthorship 1620050938196660Gruionu G, Baish J, McMahon S, Blauvelt D, Gruionu LG, Lenco MO, Vakoc BJ, Padera TP, Munn LLResearch squareExperimental and Theoretical Model of Single Vessel Minimally Invasive Micro-Laser Ablation: Inducing Microvascular Network Remodeling and Blood Flow Redistribution Without Compromising Host Tissue Function. Res Sq. 2023 Dec 18.Res Sq2023-12-18T00:00:002023Experimental and Theoretical Model of Single Vessel Minimally Invasive Micro-Laser Ablation: Inducing Microvascular Network Remodeling and Blood Flow Redistribution Without Compromising Host Tissue Function.Authorship 16216871538234841Jain R, Krishnan S, Lee S, Amoozgar Z, Subudhi S, Kumar A, Posada J, Lindeman N, Lei P, Duquette M, Roberge S, Huang P, Andersson P, Datta M, Munn L, Fukumura DResearch squareWnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma. Res Sq. 2023 Dec 26.Res Sq2023-12-26T00:00:002023Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma.Authorship 16232431838260999Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DGCancer immunology researchReprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy. Cancer Immunol Res. 2024 Jan 23.Cancer Immunol Res2024-01-23T00:00:002024Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.true1Judah Folkman Professor of Vascular Biology in the Department of SurgeryJudah Folkman Professor of Vascular Biology in the Department of SurgeryAuthorship 5565772Authorship 4069163Authorship 449382Authorship 4760233Authorship 2858172Authorship 6584002Authorship 6493882Authorship 6504242Authorship 6489882Authorship 668342223818669Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMeasuring interstitial pH and pO2 in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):675-7.Cold Spring Harb Protoc2013-07-01T00:00:002013Measuring interstitial pH and pO2 in mouse tumors.23734020Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMeasuring leukocyte-endothelial interactions in mice. Cold Spring Harb Protoc. 2013 Jun 01; 2013(6):561-3.Cold Spring Harb Protoc2013-06-01T00:00:002013Measuring leukocyte-endothelial interactions in mice.23670727Duda DG, Munn LL, Jain RKJournal of the National Cancer InstituteCan we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling? J Natl Cancer Inst. 2013 Jun 05; 105(11):762-5.J Natl Cancer Inst2013-05-13T00:00:002013Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?23818670Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMeasuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):678-80.Cold Spring Harb Protoc2013-07-01T00:00:002013Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.23637370Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMeasuring vascular permeability in mice. Cold Spring Harb Protoc. 2013 May 01; 2013(5):444-6.Cold Spring Harb Protoc2013-05-01T00:00:002013Measuring vascular permeability in mice.Authorship 681474424077103Qazi H, Palomino R, Shi ZD, Munn LL, Tarbell JMIntegrative biology : quantitative biosciences from nano to macroCancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion. Integr Biol (Camb). 2013 Nov; 5(11):1334-43.Integr Biol (Camb)2013-09-30T00:00:002013Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.Authorship 1699125Authorship 1896043Authorship 2116303Authorship 701497124304856Munn LLPhysical biologyDynamics of tissue topology during cancer invasion and metastasis. Phys Biol. 2013 Dec; 10(6):065003.Phys Biol2013-12-04T00:00:002013Dynamics of tissue topology during cancer invasion and metastasis.Authorship 2638611Authorship 3145592Authorship 3421368Authorship 3278335Authorship 2158902Authorship 1880412Authorship 2720482Authorship 2806704Authorship 3574106Authorship 7434601025026209Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RKCancer cellCompression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5.Cancer Cell2014-07-14T00:00:002014Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure.Authorship 3398816Authorship 4604106Authorship 600607Authorship 904172Authorship 4611061Authorship 470285Authorship 772748325468609Song JW, Bazou D, Munn LLMethods in molecular biology (Clifton, N.J.)Microfluidic model of angiogenic sprouting. Methods Mol Biol. 2015; 1214:243-54.Methods Mol Biol2015-01-01T00:00:002015Microfluidic model of angiogenic sprouting.Authorship 775234124956510Munn LL, Padera TPMicrovascular researchImaging the lymphatic system. Microvasc Res. 2014 Nov; 96:55-63.Microvasc Res2014-06-21T00:00:002014Imaging the lymphatic system.Authorship 5052606Authorship 586115Authorship 5619767Authorship 5706988Authorship 4014609Authorship 1859532Authorship 5609448Authorship 821623Authorship 2302002Authorship 2405232Authorship 27821011Authorship 2669996Authorship 21072110Authorship 5734641Authorship 2705013Authorship 371323Authorship 13933111Authorship 4414445Authorship 2801512Authorship 3792156Authorship 4219985Authorship 4812912Authorship 2774272Authorship 2774983Authorship 4102153Authorship 3920386Authorship 796571125636584Munn LLSeminars in cell & developmental biologyMechanobiology of lymphatic contractions. Semin Cell Dev Biol. 2015 Feb; 38:67-74.Semin Cell Dev Biol2015-01-28T00:00:002015Mechanobiology of lymphatic contractions.Authorship 2546624Authorship 2593582Authorship 3538982Authorship 3033012Authorship 4537706Authorship 4319343Authorship 831055526283382Kunert C, Baish JW, Liao S, Padera TP, Munn LLProceedings of the National Academy of Sciences of the United States of AmericaMechanobiological oscillators control lymph flow. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10938-43.Proc Natl Acad Sci U S A2015-08-17T00:00:002015Mechanobiological oscillators control lymph flow.Authorship 858009526719425Kunert C, Baish JW, Liao S, Padera TP, Munn LLProceedings of the National Academy of Sciences of the United States of AmericaReply to Davis: Nitric oxide regulates lymphatic contractions. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E106.Proc Natl Acad Sci U S A2015-12-30T00:00:002015Reply to Davis: Nitric oxide regulates lymphatic contractions.27044098Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaAng-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4476-81.Proc Natl Acad Sci U S A2016-04-04T00:00:002016Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.Authorship 379415Authorship 8779292327128791Gruionu G, Bazou D, Maimon N, Onita-Lenco M, Gruionu LG, Huang P, Munn LLLab on a chipImplantable tissue isolation chambers for analyzing tumor dynamics in vivo. Lab Chip. 2016 05 21; 16(10):1840-51.Lab Chip2016-04-29T00:00:002016Implantable tissue isolation chambers for analyzing tumor dynamics in vivo.Authorship 8823297Authorship 5162152Authorship 5164582Authorship 5354493Authorship 56930222Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor3Lecturer5Other FacultyAuthorship 893460326863922Padera TP, Meijer EF, Munn LLAnnual review of biomedical engineeringThe Lymphatic System in Disease Processes and Cancer Progression. Annu Rev Biomed Eng. 2016 07 11; 18:125-58.Annu Rev Biomed Eng2016-02-05T00:00:002016The Lymphatic System in Disease Processes and Cancer Progression.Authorship 48088541900-01-01MUNN, LANCE L1996-01-15MOLECULAR BIOPHYSICS OF LYMPHOCYTE ADHESIONF32CA0616312010-08-31MUNN, LANCE L2007-09-01Microfluidic Device for Isolating Rare Blood CellsR21CA1267612008-05-31MUNN, LANCE L2000-06-01Blood rheology, cell adhesion and endothelial activationR01HL0642402014-04-30MUNN, LANCE L2010-06-01Flow-based remodeling and function of tumor vasculatureR01CA1492852008-07-31MUNN, LANCE L2003-08-01Blood Rheology and Leukocyte MechanicsK02HL0732372020-11-30MUNN, LANCE L2015-08-01Systems biology of lymphatic transportR01HL1281682016-02-28MUNN, LANCE L2012-03-08Encouraging anastomosis of engrafted vascular networksR01HL1065842018-04-30JAIN, RAKESH K.2000-08-11Integrative Pathophysiology of Solid TumorsP01CA0801242012-03-31MUNN, LANCE L2000-06-01Blood rheology: analytical approaches to sickle cell diseaseR56HL064240Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal Investigator27543953Qazi H, Shi ZD, Song JW, Cancel LM, Huang P, Zeng Y, Roberge S, Munn LL, Tarbell JMInternational journal of cancerHeparan sulfate proteoglycans mediate renal carcinoma metastasis. Int J Cancer. 2016 Dec 15; 139(12):2791-2801.Int J Cancer2016-09-09T00:00:002016Heparan sulfate proteoglycans mediate renal carcinoma metastasis.Authorship 9194316Authorship 9217612Authorship 9239308Authorship 924052719343080Sun C, Munn LLComputers & mathematics with applications (Oxford, England : 1987)Lattice Boltzmann simulation of blood flow in digitized vessel networks. Comput Math Appl. 2008 Apr; 55(7):1594-1600.Comput Math Appl2008-04-01T00:00:002008Lattice Boltzmann simulation of blood flow in digitized vessel networks.24353926Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RKIntravitalVideo-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 2012; 1(1).Intravital2012-01-01T00:00:002012Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.27669993Bazou D, Ng MR, Song JW, Chin SM, Maimon N, Munn LLScientific reportsFlow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting. Sci Rep. 2016 Sep 27; 6:34046.Sci Rep2016-09-27T00:00:002016Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.Authorship 4708228Authorship 4728856Authorship 5383203Authorship 5403264Authorship 935885427787529Bazou D, Maimon N, Gruionu G, Munn LLIntegrative biology : quantitative biosciences from nano to macroSelf-assembly of vascularized tissue to support tumor explants in vitro. Integr Biol (Camb). 2016 12 05; 8(12):1301-1311.Integr Biol (Camb)2016-12-05T00:00:002016Self-assembly of vascularized tissue to support tumor explants in vitro.2021-11-30MUNN, LANCE L2016-12-01Targeting glycocalyx-mediated mechanisms of tumor metastasisR01CA204949Principal InvestigatorAuthorship 9423871Authorship 940845427943646Munn LLWiley interdisciplinary reviews. Systems biology and medicineCancer and inflammation. Wiley Interdiscip Rev Syst Biol Med. 2017 03; 9(2).Wiley Interdiscip Rev Syst Biol Med2016-12-12T00:00:002016Cancer and inflammation.27935958Baish JW, Kunert C, Padera TP, Munn LLPLoS computational biologySynchronization and Random Triggering of Lymphatic Vessel Contractions. PLoS Comput Biol. 2016 12; 12(12):e1005231.PLoS Comput Biol2016-12-09T00:00:002016Synchronization and Random Triggering of Lymphatic Vessel Contractions.Authorship 4129884Authorship 951300628096337Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev IProceedings of the National Academy of Sciences of the United States of AmericaStress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1033-1038.Proc Natl Acad Sci U S A2017-01-17T00:00:002017Stress granule-associated protein G3BP2 regulates breast tumor initiation.Authorship 53092898777057Munn LL, Koenig GC, Jain RK, Melder RJBioTechniquesKinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry. Biotechniques. 1995 Oct; 19(4):622-6, 628-31.Biotechniques1995-10-01T00:00:001995Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.8804629Munn LL, Melder RJ, Jain RKBiophysical journalRole of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation. Biophys J. 1996 Jul; 71(1):466-78.Biophys J1996-07-01T00:00:001996Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.8778579Patan S, Munn LL, Jain RKMicrovascular researchIntussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc Res. 1996 Mar; 51(2):260-72.Microvasc Res1996-03-01T00:00:001996Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.8994592Neelamegham S, Munn LL, Zygourakis KBiophysical journalA model for the kinetics of homotypic cellular aggregation under static conditions. Biophys J. 1997 Jan; 72(1):51-64.Biophys J1997-01-01T00:00:001997A model for the kinetics of homotypic cellular aggregation under static conditions.11381172Melder RJ, Kristensen CA, Munn LL, Jain RKBiorheologyModulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery. Biorheology. 2001; 38(2-3):151-9.Biorheology2001-01-01T00:00:002001Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.11597997Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LLCirculation researchVascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation. Circ Res. 2001 Oct 12; 89(8):732-9.Circ Res2001-10-12T00:00:002001Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.12324405Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LLBiophysical journalRed blood cells augment leukocyte rolling in a virtual blood vessel. Biophys J. 2002 Oct; 83(4):1834-41.Biophys J2002-10-01T00:00:002002Red blood cells augment leukocyte rolling in a virtual blood vessel.8842491Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJCancer metastasis reviewsLeukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Rev. 1996 Jun; 15(2):195-204.Cancer Metastasis Rev1996-06-01T00:00:001996Leukocyte-endothelial adhesion and angiogenesis in tumors.10329263Lichtenbeld HC, Ferarra N, Jain RK, Munn LLMicrovascular researchEffect of local anti-VEGF antibody treatment on tumor microvessel permeability. Microvasc Res. 1999 May; 57(3):357-62.Microvasc Res1999-05-01T00:00:001999Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.9176401Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJThe American journal of pathologyEarly events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane. Am J Pathol. 1997 Jun; 150(6):2099-112.Am J Pathol1997-06-01T00:00:001997Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.15342367Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RKCancer researchDifferential transplantability of tumor-associated stromal cells. Cancer Res. 2004 Sep 01; 64(17):5920-4.Cancer Res2004-09-01T00:00:002004Differential transplantability of tumor-associated stromal cells.8782456Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RKNature medicineDuring angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med. 1996 Sep; 2(9):992-7.Nat Med1996-09-01T00:00:001996During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.12706657Munn LLDrug discovery todayAberrant vascular architecture in tumors and its importance in drug-based therapies. Drug Discov Today. 2003 May 01; 8(9):396-403.Drug Discov Today2003-05-01T00:00:002003Aberrant vascular architecture in tumors and its importance in drug-based therapies.17677389Dupin MM, Halliday I, Care CM, Alboul L, Munn LLPhysical review. E, Statistical, nonlinear, and soft matter physicsModeling the flow of dense suspensions of deformable particles in three dimensions. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Jun; 75(6 Pt 2):066707.Phys Rev E Stat Nonlin Soft Matter Phys2007-06-27T00:00:002007Modeling the flow of dense suspensions of deformable particles in three dimensions.11597996Patan S, Munn LL, Tanda S, Roberge S, Jain RK, Jones RCCirculation researchVascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy. Circ Res. 2001 Oct 12; 89(8):723-31.Circ Res2001-10-12T00:00:002001Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.14609526Roose T, Netti PA, Munn LL, Boucher Y, Jain RKMicrovascular researchSolid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvasc Res. 2003 Nov; 66(3):204-12.Microvasc Res2003-11-01T00:00:002003Solid stress generated by spheroid growth estimated using a linear poroelasticity model.9162265Melder RJ, Koenig GC, Munn LL, Jain RKNatural immunityAdhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions. Nat Immun. 1996-1997; 15(2-3):154-63.Nat Immun1996-01-01T00:00:001996Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.11922388Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RKNeoplasia (New York, N.Y.)Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia. 2002 Jan-Feb; 4(1):3-8.Neoplasia2002-01-01T00:00:002002Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.12775571Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RKBloodA mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood. 2003 Oct 01; 102(7):2555-61.Blood2003-05-29T00:00:002003A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.16258121Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GYJournal of clinical oncology : official journal of the American Society of Clinical OncologySurrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9.J Clin Oncol2005-11-01T00:00:002005Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.11233608Yuan J, Melder RJ, Jain RK, Munn LLBioTechniquesLateral view flow system for studies of cell adhesion and deformation under flow conditions. Biotechniques. 2001 Feb; 30(2):388-94.Biotechniques2001-02-01T00:00:002001Lateral view flow system for studies of cell adhesion and deformation under flow conditions.15994941Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher YCancer researchLack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Res. 2005 Jul 01; 65(13):5674-82.Cancer Res2005-07-01T00:00:002005Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.28568605Bazou D, Maimon N, Gruionu G, Grahovac J, Seano G, Liu H, Evans CL, Munn LLJournal of tissue engineering and regenerative medicineVascular beds maintain pancreatic tumour explants for ex vivo drug screening. J Tissue Eng Regen Med. 2018 01; 12(1):e318-e322.J Tissue Eng Regen Med2017-09-12T00:00:002017Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.16794827Jones R, Capen D, Jacobson M, Munn LCell and tissue researchPDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension. Cell Tissue Res. 2006 Dec; 326(3):759-69.Cell Tissue Res2006-06-23T00:00:002006PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension.Authorship 985853815613630Sun C, Munn LLBiophysical journalParticulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis. Biophys J. 2005 Mar; 88(3):1635-45.Biophys J2004-12-21T00:00:002004Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis.17846892Sun C, Jain RK, Munn LLAnnals of biomedical engineeringNon-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion. Ann Biomed Eng. 2007 Dec; 35(12):2121-9.Ann Biomed Eng2007-09-11T00:00:002007Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.11121063Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LLProceedings of the National Academy of Sciences of the United States of AmericaMosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14608-13.Proc Natl Acad Sci U S A2000-12-19T00:00:002000Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.19151720Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher YNature methodsIn vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5.Nat Methods2009-01-18T00:00:002009In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.19247489Cheng G, Tse J, Jain RK, Munn LLPloS oneMicro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. PLoS One. 2009; 4(2):e4632.PLoS One2009-02-27T00:00:002009Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.12192604Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RKNeoplasia (New York, N.Y.)Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model. Neoplasia. 2002 Sep-Oct; 4(5):449-63.Neoplasia2002-09-01T00:00:002002Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.15059900Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LLCancer researchDifferential gene expression in metastasizing cells shed from kidney tumors. Cancer Res. 2004 Apr 01; 64(7):2469-73.Cancer Res2004-04-01T00:00:002004Differential gene expression in metastasizing cells shed from kidney tumors.15951843Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura DThe Journal of clinical investigationNO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27.J Clin Invest2005-06-09T00:00:002005NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.8580357Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RKBiophysical journalSelectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. Biophys J. 1995 Nov; 69(5):2131-8.Biophys J1995-11-01T00:00:001995Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.15994949di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LLCancer researchMosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Res. 2005 Jul 01; 65(13):5740-9.Cancer Res2005-07-01T00:00:002005Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.19352490di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RKPloS onePDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One. 2009; 4(4):e5123.PLoS One2009-04-08T00:00:002009PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.22558206Plotkin SR, Bredella MA, Cai W, Kassarjian A, Harris GJ, Esparza S, Merker VL, Munn LL, Muzikansky A, Askenazi M, Nguyen R, Wenzel R, Mautner VFPloS oneQuantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis. PLoS One. 2012; 7(4):e35711.PLoS One2012-04-27T00:00:002012Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis.55 Fruit StMassachusetts General HospitalRadiation Oncology, Cox 755 Fruit StBoston02114MA21773633Jain A, Munn LLLab on a chipBiomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip. Lab Chip. 2011 Sep 07; 11(17):2941-7.Lab Chip2011-07-20T00:00:002011Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.21701514Kozin SV, Duda DG, Munn LL, Jain RKNature reviews. CancerIs vasculogenesis crucial for the regrowth of irradiated tumours? Nat Rev Cancer. 2011 Jun 24; 11(7):532.Nat Rev Cancer2011-06-24T00:00:002011Is vasculogenesis crucial for the regrowth of irradiated tumours?11421658Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher YMicrovascular researchDecorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1. Microvasc Res. 2001 Jul; 62(1):26-42.Microvasc Res2001-07-01T00:00:002001Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.15679363Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MWAnalytical chemistryBiomimetic autoseparation of leukocytes from whole blood in a microfluidic device. Anal Chem. 2005 Feb 01; 77(3):933-7.Anal Chem2005-02-01T00:00:002005Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device.23045683Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MCProceedings of the National Academy of Sciences of the United States of AmericaVascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17561-6.Proc Natl Acad Sci U S A2012-10-08T00:00:002012Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.Authorship 10156941828966873Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RKNature biomedical engineeringSolid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1.Nat Biomed Eng2016-11-28T00:00:002016Solid stress and elastic energy as measures of tumour mechanopathology.10684738Melder RJ, Yuan J, Munn LL, Jain RKMicrovascular researchErythrocytes enhance lymphocyte rolling and arrest in vivo. Microvasc Res. 2000 Mar; 59(2):316-22.Microvasc Res2000-03-01T00:00:002000Erythrocytes enhance lymphocyte rolling and arrest in vivo.11953828Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RKBritish journal of cancerSolid stress facilitates spheroid formation: potential involvement of hyaluronan. Br J Cancer. 2002 Mar 18; 86(6):947-53.Br J Cancer2002-03-18T00:00:002002Solid stress facilitates spheroid formation: potential involvement of hyaluronan.17466902Bockhorn M, Jain RK, Munn LLThe Lancet. OncologyActive versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? Lancet Oncol. 2007 May; 8(5):444-8.Lancet Oncol2007-05-01T00:00:002007Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?23073300Song JW, Daubriac J, Tse JM, Bazou D, Munn LLLab on a chipRhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis. Lab Chip. 2012 Dec 07; 12(23):5000-6.Lab Chip2012-12-07T00:00:002012RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis.14745444Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RKNature medicineDirect evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7.Nat Med2004-01-25T00:00:002004Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.12829477Sun C, Migliorini C, Munn LLBiophysical journalRed blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis. Biophys J. 2003 Jul; 85(1):208-22.Biophys J2003-07-01T00:00:002003Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.21571860Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher YCancer researchCancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res. 2011 Jul 01; 71(13):4527-38.Cancer Res2011-05-13T00:00:002011Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.22572994Kozin SV, Duda DG, Munn LL, Jain RKJournal of the National Cancer InstituteNeovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? J Natl Cancer Inst. 2012 Jun 20; 104(12):899-905.J Natl Cancer Inst2012-05-09T00:00:002012Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?23282642Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsLung window preparation in mice. Cold Spring Harb Protoc. 2013 Jan 01; 2013(1).Cold Spring Harb Protoc2013-01-01T00:00:002013Lung window preparation in mice.19749772Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BENature medicineThree-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009 Oct; 15(10):1219-23.Nat Med2009-09-13T00:00:002009Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.20647356Brown E, Munn LL, Fukumura D, Jain RKCold Spring Harbor protocolsIn vivo imaging of tumors. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5452.Cold Spring Harb Protoc2010-07-01T00:00:002010In vivo imaging of tumors.22203958Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LLProceedings of the National Academy of Sciences of the United States of AmericaMechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):911-6.Proc Natl Acad Sci U S A2011-12-27T00:00:002011Mechanical compression drives cancer cells toward invasive phenotype.23028076Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsMammary fat pad tumor preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1115-6.Cold Spring Harb Protoc2012-10-01T00:00:002012Mammary fat pad tumor preparation in mice.23118364Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsLymphangiography of the mouse tail. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1177-8.Cold Spring Harb Protoc2012-11-01T00:00:002012Lymphangiography of the mouse tail.23209022Kesler CT, Liao S, Munn LL, Padera TPWiley interdisciplinary reviews. Systems biology and medicineLymphatic vessels in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb; 5(1):111-24.Wiley Interdiscip Rev Syst Biol Med2012-12-03T00:00:002012Lymphatic vessels in health and disease.Authorship 1037830529312532Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev IOncotargetSecretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 2017 Dec 12; 8(65):108292-108302.Oncotarget2017-11-26T00:00:002017Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.20816045Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RKBiophysical journalDiffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J. 2010 Sep 08; 99(5):1342-9.Biophys J2010-09-08T00:00:002010Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.22932871Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RKProceedings of the National Academy of Sciences of the United States of AmericaCauses, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8.Proc Natl Acad Sci U S A2012-08-29T00:00:002012Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.22949714Jain RK, Munn LL, Fukumura DCold Spring Harbor protocolsCorneal pocket assay in rabbits. Cold Spring Harb Protoc. 2012 Sep 01; 2012(9):1017-8.Cold Spring Harb Protoc2012-09-01T00:00:002012Corneal pocket assay in rabbits.Authorship 10388711029343625Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TPScience translational medicineMethicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med. 2018 01 17; 10(424).Sci Transl Med2018-01-17T00:00:002018Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.Authorship 1040641129356683Munn LL, Garkavtsev IAgingSLPI: a new target for stopping metastasis. Aging (Albany NY). 2018 Jan 20; 10(1):13-14.Aging (Albany NY)2018-01-20T00:00:002018SLPI: a new target for stopping metastasis.21370203Jain RK, Munn LL, Fukumura D, Melder RJMethods in molecular medicineIn vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium. Methods Mol Med. 1999; 18:553-75.Methods Mol Med1999-01-01T00:00:001999In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.21876168Song JW, Munn LLProceedings of the National Academy of Sciences of the United States of AmericaFluid forces control endothelial sprouting. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15342-7.Proc Natl Acad Sci U S A2011-08-29T00:00:002011Fluid forces control endothelial sprouting.Authorship 100752811976409Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RKScience (New York, N.Y.)Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6.Science2002-04-25T00:00:002002Lymphatic metastasis in the absence of functional intratumor lymphatics.