Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry. 2009 Mar 24; 48(11):2538-49.
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.
Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC
Cancer vulnerabilities unveiled by genomic loss. Cell. 2012 Aug 17; 150(4):842-54.
Cancer vulnerabilities unveiled by genomic loss.
Lecturer on Biological Chemistry and Molecular Pharmacology
Louise Foote Pfeiffer Professor of Cell Biology
George E. Thibault Academy Associate Professor of Medicine
Ellen and Melvin Gordon Distinguished Professor of Medical Education
Harry C. McKenzie Professor of Cell Biology
Harold T. White Professor of Biological Chemistry and Molecular Pharmacology
Schwartzstein RM, Dienstag JL, King RW, Chang BS, Flanagan JG, Besche HC, Hoenig MP, Miloslavsky EM, Atkins KM, Puig A, Cockrill BA, Wittels KA, Dalrymple JL, Gooding H, Hirsh DA, Alexander EK, Fazio SB, Hundert EM
Academic medicine : journal of the Association of American Medical Colleges
The Harvard Medical School Pathways Curriculum: Reimagining Developmentally Appropriate Medical Education for Contemporary Learners. Acad Med. 2020 11; 95(11):1687-1695.
The Harvard Medical School Pathways Curriculum: Reimagining Developmentally Appropriate Medical Education for Contemporary Learners.
Ensuring Equitable Access to Remote Learning During the COVID-19 Pandemic. Acad Med. 2021 May 01; 96(5):e19-e20.
Ensuring Equitable Access to Remote Learning During the COVID-19 Pandemic.
Understanding and Optimizing Group Dynamics in Case-Based Collaborative Learning. Med Sci Educ. 2021 Dec; 31(6):1779-1788.
Understanding and Optimizing Group Dynamics in Case-Based Collaborative Learning.
Miloslavsky EM, Besche HC, Calderwood SB, Chang BS, Dienstag JL, King RW, Mitchell RN, Schwartzstein RM, Thomas H, Hundert EM, Flanagan JG
Advanced Integrated Science Courses: Building a Skill Set to Engage With the Interface of Research and Medicine. Acad Med. 2022 10 01; 97(10):1467-1473.
Advanced Integrated Science Courses: Building a Skill Set to Engage With the Interface of Research and Medicine.
Besche HC, Onorato S, Pelletier S, Ashrafzadeh S, Joshi A, Nelsen B, Yoon J, Zhou J, Schwartz A, Cockrill BA
A hierarchy of needs for remote undergraduate medical education: lessons from the medical student experience. BMC Med Educ. 2022 Jun 02; 22(1):423.
A hierarchy of needs for remote undergraduate medical education: lessons from the medical student experience.
Boyd T, Besche H, Goldhammer R, Alblooshi A, Coleman BI
First-year medical students' perceptions of a self-regulated learning-informed intervention: an exploratory study. BMC Med Educ. 2022 Nov 29; 22(1):821.
First-year medical students' perceptions of a self-regulated learning-informed intervention: an exploratory study.
Fischer K, Sullivan AM, Cohen AP, King RW, Cockrill BA, Besche HC
Using cognitive load theory to evaluate and improve preparatory materials and study time for the flipped classroom. BMC Med Educ. 2023 May 17; 23(1):345.
Using cognitive load theory to evaluate and improve preparatory materials and study time for the flipped classroom.
Do M, Sanford K, Roseff S, Hovaguimian A, Besche H, Fischer K
Gamified versus non-gamified online educational modules for teaching clinical laboratory medicine to first-year medical students at a large allopathic medical school in the United States. BMC Med Educ. 2023 Dec 14; 23(1):959.
Gamified versus non-gamified online educational modules for teaching clinical laboratory medicine to first-year medical students at a large allopathic medical school in the United States.
Daddario S, Manning ME, Miloslavsky EM, Besche HC
Enhancing autonomy in clinical elective selection: Student-driven insights. Med Educ. 2024 05; 58(5):605.
Enhancing autonomy in clinical elective selection: Student-driven insights.
Temporary Academic-Co-Course Director for HMI
The Role of Inclusion in Collaborative Learning. Med Sci Educ. 2024 Aug; 34(4):909-913.
The Role of Inclusion in Collaborative Learning.
The Shadow Economy of Effort: Unintended Consequences of Pass/Fail Grading on Medical Students' Clinical Education and Patient Care Skills. Acad Med. 2025 04 01; 100(4):419-424.
The Shadow Economy of Effort: Unintended Consequences of Pass/Fail Grading on Medical Students' Clinical Education and Patient Care Skills.
Besche HC, King RW, Shafer KM, Fleet SE, Charles JF, Kaplan TB, Greenzang KA, Hoenig MP, Schwartzstein RM, Cockrill BA, Fischer K
Journal of medical education and curricular development
Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning. J Med Educ Curric Dev. 2025 Jan-Dec; 12:23821205251317149.
Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning.
Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. EMBO J. 2014 May 16; 33(10):1159-76.
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
Harz D, Esparza-Perez RI, Sullivan A, Delgado-Figueroa N, Colunga-Lozano LE, Fischer K, Campos-Zamora M, Besche H
How Specific Instructional Design Elements Influence the Experience of Case-Based Collaborative Learning in a Mexican Medical School: A Mixed-Methods Study. J Med Educ Curric Dev. 2025 Jan-Dec; 12:23821205251385013.
How Specific Instructional Design Elements Influence the Experience of Case-Based Collaborative Learning in a Mexican Medical School: A Mixed-Methods Study.
260 Longwood Avenue, Medical Education Center
Twelve tips for the production of digital chalk-talk videos. Med Teach. 2017 Jun; 39(6):653-659.
Twelve tips for the production of digital chalk-talk videos.
Getting to first base in proteasome assembly. Cell. 2009 Jul 10; 138(1):25-8.
Getting to first base in proteasome assembly.
Tai HC, Besche H, Goldberg AL, Schuman EM
Characterization of the Brain 26S Proteasome and its Interacting Proteins. Front Mol Neurosci. 2010; 3.
Characterization of the Brain 26S Proteasome and its Interacting Proteins.
Methods in molecular biology (Clifton, N.J.)
Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain. Methods Mol Biol. 2012; 832:423-32.
Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain.
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol Cell. 2009 Dec 11; 36(5):794-804.
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.
Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem. 2010 Dec 17; 285(51):39597-608.
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.