Stem cell transplantation and tissue engineering hold great promise in regenerative medicine. However, engrafting stem cells and generating tissues with stable vascular beds remain major challenges. Our laboratory is interested in understanding mechanisms of vascular network formation and stem cell engraftment using human stem and progenitor cells. Our long-term goal is to develop novel therapeutic strategies in regenerative medicine. Current projects in the lab are focused on: 1) Endothelial progenitor cell biology and therapeutic potential 2) Bioengineering vascular networks 3) Genetically-engineered vasculature for drug delivery Please visit our website for more information: meleromartinlab.com
Melero-Martin JM, De Obaldia ME, Allen P, Dudley AC, Klagsbrun M, Bischoff J
Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo. Tissue Eng Part A. 2010 Aug; 16(8):2457-66.
Host myeloid cells are necessary for creating bioengineered human vascular networks in vivo.
Chapter 13. An in vivo experimental model for postnatal vasculogenesis. Methods Enzymol. 2008; 445:303-29.
Chapter 13. An in vivo experimental model for postnatal vasculogenesis.
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW
Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532.
Consensus guidelines for the use and interpretation of angiogenesis assays.
Lin RZ, Dreyzin A, Aamodt K, Li D, Jaminet SC, Dudley AC, Melero-Martin JM
Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release. Blood. 2011 Nov 17; 118(20):5420-8.
Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release.
Journal of visualized experiments : JoVE
Bioengineering human microvascular networks in immunodeficient mice. J Vis Exp. 2011 Jul 11; (53):e3065.
Bioengineering human microvascular networks in immunodeficient mice.
Chuang CH, Lin RZ, Melero-Martin JM, Chen YC
Artificial cells, nanomedicine, and biotechnology
Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue. Artif Cells Nanomed Biotechnol. 2018; 46(sup3):S434-S447.
Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue.
Khan ZA, Boscolo E, Picard A, Psutka S, Melero-Martin JM, Bartch TC, Mulliken JB, Bischoff J
Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest. 2008 Jul; 118(7):2592-9.
Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice.
Gottlieb D, Kunal T, Emani S, Aikawa E, Brown DW, Powell AJ, Nedder A, Engelmayr GC, Melero-Martin JM, Sacks MS, Mayer JE
The Journal of thoracic and cardiovascular surgery
In vivo monitoring of function of autologous engineered pulmonary valve. J Thorac Cardiovasc Surg. 2010 Mar; 139(3):723-31.
In vivo monitoring of function of autologous engineered pulmonary valve.
Moeinzadeh S, Shariati SRP, Kader S, Melero-Martin JM, Jabbari E
Devitalized Stem Cell Microsheets for Sustainable Release of Osteogenic and Vasculogenic Growth Factors and Regulation of Anti-Inflammatory Immune Response. Adv Biosyst. 2017 Mar; 1(3).
Devitalized Stem Cell Microsheets for Sustainable Release of Osteogenic and Vasculogenic Growth Factors and Regulation of Anti-Inflammatory Immune Response.
Cellular and molecular life sciences : CMLS
Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources. Cell Mol Life Sci. 2019 Feb; 76(3):421-439.
Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources.
Lin RZ, Moreno-Luna R, Zhou B, Pu WT, Melero-Martin JM
Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells. Angiogenesis. 2012 Sep; 15(3):443-55.
Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells.
Melero-Martin JM, Dowling MA, Smith M, Al-Rubeai M
Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems. Biomaterials. 2006 May; 27(15):2970-9.
Expansion of chondroprogenitor cells on macroporous microcarriers as an alternative to conventional monolayer systems.
Concise review: Vascular stem cells and tumor angiogenesis. Stem Cells. 2011 Feb; 29(2):163-8.
Concise review: Vascular stem cells and tumor angiogenesis.
Melero-Martin JM, Santhalingam S, Al-Rubeai M
Advances in biochemical engineering/biotechnology
Methodology for optimal in vitro cell expansion in tissue engineering. Adv Biochem Eng Biotechnol. 2009; 112:209-29.
Methodology for optimal in vitro cell expansion in tissue engineering.
Wagner M, Bjerkvig R, Wiig H, Melero-Martin JM, Lin RZ, Klagsbrun M, Dudley AC
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 2012 Sep; 15(3):481-95.
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.
Aldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular Research
Smadja DM, Melero-Martin JM, Eikenboom J, Bowman M, Sabatier F, Randi AM
Journal of thrombosis and haemostasis : JTH
Standardization of methods to quantify and culture endothelial colony-forming cells derived from peripheral blood: Position paper from the International Society on Thrombosis and Haemostasis SSC. J Thromb Haemost. 2019 Jul; 17(7):1190-1194.
Standardization of methods to quantify and culture endothelial colony-forming cells derived from peripheral blood: Position paper from the International Society on Thrombosis and Haemostasis SSC.
Caroline Shields Walker Professor of Medicine
A. Werk Cook Professor of Radiation Oncology (Tumor Biology)
Neumeyer J, Lin RZ, Wang K, Hong X, Hua T, Croteau SE, Neufeld EJ, Melero-Martin JM
Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream. Blood Adv. 2019 12 23; 3(24):4166-4176.
Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream.
Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson AK, Prohászka Z, Ranson M, Riva N, Senis Y, van Ommen CH, Vaughan DE, Weisel J
Research and practice in thrombosis and haemostasis
Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost. 2020 Jul; 4(5):680-713.
Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.
Methods in molecular biology (Clifton, N.J.)
In Vivo Vascular Network Forming Assay. Methods Mol Biol. 2021; 2206:193-203.
Wang K, Lin RZ, Hong X, Ng AH, Lee CN, Neumeyer J, Wang G, Wang X, Ma M, Pu WT, Church GM, Melero-Martin JM
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA. Sci Adv. 2020 07; 6(30):eaba7606.
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA.
Masoumi N, Copper D, Chen P, Cubberley A, Guo K, Lin RZ, Ahmed B, Martin D, Aikawa E, Melero-Martin J, Mayer J
Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation. Adv Funct Mater. 2017 Jul 19; 27(27).
Elastomeric Fibrous Hybrid Scaffold Supports In Vitro and In Vivo Tissue Formation.
Blandinières A, Hong X, Philippe A, Bièche I, Vacher S, Rossi E, Detriche G, Gendron N, Gaussem P, Guerin CL, Melero-Martin JM, Smadja DM
Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells. Stem Cell Rev Rep. 2021 04; 17(2):628-638.
Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells.
Ng AHM, Khoshakhlagh P, Rojo Arias JE, Pasquini G, Wang K, Swiersy A, Shipman SL, Appleton E, Kiaee K, Kohman RE, Vernet A, Dysart M, Leeper K, Saylor W, Huang JY, Graveline A, Taipale J, Hill DE, Vidal M, Melero-Martin JM, Busskamp V, Church GM
A comprehensive library of human transcription factors for cell fate engineering. Nat Biotechnol. 2021 04; 39(4):510-519.
A comprehensive library of human transcription factors for cell fate engineering.
Hong X, Oh N, Wang K, Neumeyer J, Lee CN, Lin RZ, Piekarski B, Emani S, Greene AK, Friehs I, Del Nido PJ, Melero-Martin JM
Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1. Angiogenesis. 2021 05; 24(2):327-344.
Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1.
Enhancing endothelial cell engraftment via transplantation of exogenous mitochondria
Regulation of endothelial cell specification
Kim HD, Hong X, An YH, Park MJ, Kim DG, Greene AK, Padwa BL, Hwang NS, Lin RZ, Melero-Martin JM
A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. Adv Healthc Mater. 2021 07; 10(13):e2100070.
A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification.
Melero-Martin JM, Dudley AC, Griffioen AW
Adieu to parting Editor in Chief and pioneering scientist Dr. Joyce Bischoff. Angiogenesis. 2021 05; 24(2):191-193.
Adieu to parting Editor in Chief and pioneering scientist Dr. Joyce Bischoff.
Wang X, Maxwell KG, Wang K, Bowers DT, Flanders JA, Liu W, Wang LH, Liu Q, Liu C, Naji A, Wang Y, Wang B, Chen J, Ernst AU, Melero-Martin JM, Millman JR, Ma M
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes. Sci Transl Med. 2021 06 02; 13(596).
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes.
Wang X, Brown NK, Wang B, Shariati K, Wang K, Fuchs S, Melero-Martin JM, Ma M
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Local Immunomodulatory Strategies to Prevent Allo-Rejection in Transplantation of Insulin-Producing Cells. Adv Sci (Weinh). 2021 09; 8(17):e2003708.
Local Immunomodulatory Strategies to Prevent Allo-Rejection in Transplantation of Insulin-Producing Cells.
Cullion K, Petishnok LC, Koo H, Harty B, Melero-Martin JM, Kohane DS
Targeting Nanoparticles to Bioengineered Human Vascular Networks. Nano Lett. 2021 08 11; 21(15):6609-6616.
Targeting Nanoparticles to Bioengineered Human Vascular Networks.
Liu Q, Wang X, Chiu A, Liu W, Fuchs S, Wang B, Wang LH, Flanders J, Zhang Y, Wang K, Melero-Martin JM, Ma M
Advanced materials (Deerfield Beach, Fla.)
A Zwitterionic Polyurethane Nanoporous Device with Low Foreign-Body Response for Islet Encapsulation. Adv Mater. 2021 Oct; 33(39):e2102852.
A Zwitterionic Polyurethane Nanoporous Device with Low Foreign-Body Response for Islet Encapsulation.
Klouda T, Hao Y, Kim H, Kim J, Olejnik J, Hume AJ, Ayyappan S, Hong X, Melero-Martin J, Fang Y, Wang Q, Zhou X, Mühlberger E, Jia H, Padera RF, Raby BA, Yuan K
Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2. Angiogenesis. 2022 05; 25(2):225-240.
Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2.
Vorisek C, Weixler V, Dominguez M, Axt-Fliedner R, Hammer PE, Lin RZ, Melero-Martin JM, Del Nido PJ, Friehs I
Mechanical strain triggers endothelial-to-mesenchymal transition of the endocardium in the immature heart. Pediatr Res. 2022 09; 92(3):721-728.
Mechanical strain triggers endothelial-to-mesenchymal transition of the endocardium in the immature heart.
Liu W, Flanders JA, Wang LH, Liu Q, Bowers DT, Wang K, Chiu A, Wang X, Ernst AU, Shariati K, Caserto JS, Parker B, Gao D, Plesser MD, Grunnet LG, Rescan C, Pimentel Carletto R, Winkel L, Melero-Martin JM, Ma M
Small (Weinheim an der Bergstrasse, Germany)
A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells. Small. 2022 02; 18(8):e2104899.
A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells.
Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND
Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 01 01; 45(1):3-22.
Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.
Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J
Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 11 13.
Oh NA, Hong X, Doulamis IP, Meibalan E, Peiseler T, Melero-Martin J, García-Cardeña G, Del Nido PJ, Friehs I
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment. JACC Basic Transl Sci. 2021 Dec; 6(12):984-999.
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment.
Galeano-Valle F, Díaz-Crespo FJ, Melero-Martín R, Apaza-Chávez JE, Del-Toro-Cervera J, Demelo-Rodríguez P
Massive generalized crystal-storing histiocytosis associated with extracellular crystalline nephropathy: clinical, immunohistochemical, and ultrastructural studies of a unique disorder and review of the literature. CEN Case Rep. 2019 08; 8(3):166-172.
Massive generalized crystal-storing histiocytosis associated with extracellular crystalline nephropathy: clinical, immunohistochemical, and ultrastructural studies of a unique disorder and review of the literature.
Cold Spring Harbor perspectives in medicine
Human Endothelial Colony-Forming Cells. Cold Spring Harb Perspect Med. 2022 12 01; 12(12).
Wang X, Wang K, Yu M, Velluto D, Hong X, Wang B, Chiu A, Melero-Martin JM, Tomei AA, Ma M
Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression. Sci Adv. 2022 07 22; 8(29):eabn0071.
Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression.
Blandinières A, Randi AM, Paschalaki KE, Guerin CL, Melero-Martin JM, Smadja DM
Results of an international survey about methods used to isolate human endothelial colony-forming cells: guidance from the SSC on Vascular Biology of the ISTH. J Thromb Haemost. 2023 09; 21(9):2611-2619.
Results of an international survey about methods used to isolate human endothelial colony-forming cells: guidance from the SSC on Vascular Biology of the ISTH.
Hong X, Luo AC, Doulamis I, Oh N, Im GB, Lin CY, Del Nido PJ, Lin RZ, Melero-Martin JM
Photopolymerizable Hydrogel for Enhanced Intramyocardial Vascular Progenitor Cell Delivery and Post-Myocardial Infarction Healing. Adv Healthc Mater. 2023 11; 12(29):e2301581.
Photopolymerizable Hydrogel for Enhanced Intramyocardial Vascular Progenitor Cell Delivery and Post-Myocardial Infarction Healing.
Wei SY, Chen PY, Hsieh CC, Chen YS, Chen TH, Yu YS, Tsai MC, Xie RH, Chen GY, Yin GC, Melero-Martin JM, Chen YC
Engineering large and geometrically controlled vascularized nerve tissue in collagen hydrogels to restore large-sized volumetric muscle loss. Biomaterials. 2023 12; 303:122402.
Engineering large and geometrically controlled vascularized nerve tissue in collagen hydrogels to restore large-sized volumetric muscle loss.
Human endothelial cell regulation of ossification
Lin RZ, Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy. Nature. 2024 05; 629(8012):660-668.
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.
A Novel Transcription Factor-Driven Approach for Mural Progenitor Cells Generation
Pericyte contribution to capillary remodeling in pulmonary arterial hypertension
Chen D, Fan X, Wang K, Gong L, Melero-Martin JM, Pu WT
bioRxiv : the preprint server for biology
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. bioRxiv. 2024 May 30.
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment.
Luo AC, Wang J, Wang K, Zhu Y, Gong L, Lee U, Li X, Tremmel DM, Lin RZ, Ingber DE, Gorman J, Melero-Martin JM
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. Angiogenesis. 2024 Nov; 27(4):779-795.
A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation.
Grattoni A, Korbutt G, Tomei AA, García AJ, Pepper AR, Stabler C, Brehm M, Papas K, Citro A, Shirwan H, Millman JR, Melero-Martin J, Graham M, Sefton M, Ma M, Kenyon N, Veiseh O, Desai TA, Nostro MC, Marinac M, Sykes M, Russ HA, Odorico J, Tang Q, Ricordi C, Latres E, Mamrak NE, Giraldo J, Poznansky MC, de Vos P
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead. Nat Rev Endocrinol. 2025 Jan; 21(1):14-30.
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.
Lin RZ, Chen YC, Moreno-Luna R, Khademhosseini A, Melero-Martin JM
Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel. Biomaterials. 2013 Sep; 34(28):6785-96.
Transdermal regulation of vascular network bioengineering using a photopolymerizable methacrylated gelatin hydrogel.
Lee U, Zhang Y, Zhu Y, Luo AC, Gong L, Tremmel DM, Kim Y, Villarreal VS, Wang X, Lin RZ, Cui M, Ma M, Yuan K, Wang K, Chen K, Melero-Martin JM
Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1. Nat Commun. 2024 09 30; 15(1):8392.
Robust differentiation of human pluripotent stem cells into mural progenitor cells via transient activation of NKX3.1.
Visiting Research Professor of the Wyss Institute
Roo D, Lee M, Amirthalingam S, Ryu KM, Kim BS, Melero-Martin JM, So KH, Hwang NS
Development of a Decellularized Urinary Bladder Matrix and Heparin-Based Cryogel for Promoting Angiogenesis. Macromol Biosci. 2025 Aug; 25(8):e2500028.
Development of a Decellularized Urinary Bladder Matrix and Heparin-Based Cryogel for Promoting Angiogenesis.
Mitochondrial transfer in endothelial cells and vascular health. Trends Cell Biol. 2025 May 13.
Mitochondrial transfer in endothelial cells and vascular health.
Moreno-Luna R, Muñoz-Hernandez R, Lin RZ, Miranda ML, Vallejo-Vaz AJ, Stiefel P, Praena-Fernández JM, Bernal-Bermejo J, Jimenez-Jimenez LM, Villar J, Melero-Martin JM
Maternal body-mass index and cord blood circulating endothelial colony-forming cells. J Pediatr. 2014 Mar; 164(3):566-571.
Maternal body-mass index and cord blood circulating endothelial colony-forming cells.
Chen D, Fan X, Sun N, Wang K, Gong L, Melero-Martin JM, Pu WT
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. Nat Cardiovasc Res. 2025 Jun; 4(6):689-709.
Muñoz-Hernandez R, Miranda ML, Stiefel P, Lin RZ, Praena-Fernández JM, Dominguez-Simeon MJ, Villar J, Moreno-Luna R, Melero-Martin JM
Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia. Hypertension. 2014 Jul; 64(1):165-71.
Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia.
Li X, Kim HD, Luo AC, Gong L, Zhu Y, Lee CN, Hong X, Sudduth CL, Ad M, An YH, Park MJ, Kim DG, Greene AK, Padwa BL, Hwang NS, Lin RZ, Melero-Martin JM
Human Bone-Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand. Adv Sci (Weinh). 2025 Sep; 12(35):e14194.
Human Bone-Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand.
Diaz-Gil D, Gierlinger G, Silva-Gomez N, Rech L, Ortiz-Urbina J, Saraci K, Koutsogiannaki S, Wolf CM, Kozlik-Feldmann RG, Mair R, Melero-Martin JM, Emani SM, García-Cardeña G, Del Nido PJ, Friehs I
Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis. JACC Basic Transl Sci. 2025 Sep; 10(9):101282.
Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis.
Santos-De-La-Mata Á, Esteban PF, Martínez-Torija M, Paniagua-Torija B, Espino-Rodríguez FJ, Beltrán-Camacho L, Camacho-Toledano C, Alcobendas-Maestro M, García-García F, Molina-Holgado E, Durán-Ruiz MC, Melero-Martin JM, Moreno-Luna R
Vasculogenic potential of adipose tissue derived stem cells from patients with chronic spinal cord injury and pressure injuries. Angiogenesis. 2025 Sep 10; 28(4):48.
Vasculogenic potential of adipose tissue derived stem cells from patients with chronic spinal cord injury and pressure injuries.
Lin RZ, Moreno-Luna R, Li D, Jaminet SC, Greene AK, Melero-Martin JM
Proceedings of the National Academy of Sciences of the United States of America
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10137-42.
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling.
Lin RZ, Hatch A, Antontsev VG, Murthy SK, Melero-Martin JM
Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo. Tissue Eng Part C Methods. 2015 Mar; 21(3):274-83.
Microfluidic capture of endothelial colony-forming cells from human adult peripheral blood: phenotypic and functional validation in vivo.
Lin CI, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SC
TM4SF1: a new vascular therapeutic target in cancer. Angiogenesis. 2014 Oct; 17(4):897-907.
TM4SF1: a new vascular therapeutic target in cancer.
Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields JM, Shelton SE, Irvin DM, Brings VE, Ollila DW, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC
Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nat Commun. 2014 Oct 22; 5:5200.
Vascular channels formed by subpopulations of PECAM1+ melanoma cells.
Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B
Epicardium-to-fat transition in injured heart. Cell Res. 2014 Nov; 24(11):1367-9.
Epicardium-to-fat transition in injured heart.
Chuang CH, Lin RZ, Tien HW, Chu YC, Li YC, Melero-Martin JM, Chen YC
Enzymatic regulation of functional vascular networks using gelatin hydrogels. Acta Biomater. 2015 Jun; 19:85-99.
Enzymatic regulation of functional vascular networks using gelatin hydrogels.
Kuo KC, Lin RZ, Tien HW, Wu PY, Li YC, Melero-Martin JM, Chen YC
Bioengineering vascularized tissue constructs using an injectable cell-laden enzymatically crosslinked collagen hydrogel derived from dermal extracellular matrix. Acta Biomater. 2015 Nov; 27:151-166.
Bioengineering vascularized tissue constructs using an injectable cell-laden enzymatically crosslinked collagen hydrogel derived from dermal extracellular matrix.
Barati D, Shariati SRP, Moeinzadeh S, Melero-Martin JM, Khademhosseini A, Jabbari E
Journal of controlled release : official journal of the Controlled Release Society
Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel. J Control Release. 2016 Feb 10; 223:126-136.
Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel.
Engineering vascularized tissue in vivo using postnatal progenitor cells
Host neutrophils as direct mediators of tissue graft revascularization
Vascular networks genetically engineered for protein drug delivery
Vascular niche bioengineering for human bone regeneration
Medina RJ, Barber CL, Sabatier F, Dignat-George F, Melero-Martin JM, Khosrotehrani K, Ohneda O, Randi AM, Chan JKY, Yamaguchi T, Van Hinsbergh VWM, Yoder MC, Stitt AW
Endothelial Progenitors: A Consensus Statement on Nomenclature. Stem Cells Transl Med. 2017 05; 6(5):1316-1320.
Endothelial Progenitors: A Consensus Statement on Nomenclature.
Kang KT, Lin RZ, Kuppermann D, Melero-Martin JM, Bischoff J
Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle. Sci Rep. 2017 04 10; 7(1):770.
Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle.
Melero-Martin JM, Khan ZA, Picard A, Wu X, Paruchuri S, Bischoff J
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood. 2007 Jun 01; 109(11):4761-8.
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells.
Melero-Martin JM, De Obaldia ME, Kang SY, Khan ZA, Yuan L, Oettgen P, Bischoff J
Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res. 2008 Jul 18; 103(2):194-202.
Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells.
Lin RZ, Dreyzin A, Aamodt K, Dudley AC, Melero-Martin JM
Functional endothelial progenitor cells from cryopreserved umbilical cord blood. Cell Transplant. 2011; 20(4):515-22.
Functional endothelial progenitor cells from cryopreserved umbilical cord blood.
Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature. Methods. 2012 Mar; 56(3):440-51.
Fibroblast growth factor-2 facilitates rapid anastomosis formation between bioengineered human vascular networks and living vasculature.
Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise Av, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May; 121(5):1894-904.
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.
Khan ZA, Melero-Martin JM, Wu X, Paruchuri S, Boscolo E, Mulliken JB, Bischoff J
Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood. 2006 Aug 01; 108(3):915-21.
Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin.
Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383.
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis.
Lin RZ, Lee CN, Moreno-Luna R, Neumeyer J, Piekarski B, Zhou P, Moses MA, Sachdev M, Pu WT, Emani S, Melero-Martin JM
Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks. Nat Biomed Eng. 2017; 1.
Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks.
Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT
Journal of molecular and cellular cardiology
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol. 2012 Jan; 52(1):43-7.
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes.
Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture. Biotechnol Bioeng. 2006 Feb 20; 93(3):519-33.
Optimal in-vitro expansion of chondroprogenitor cells in monolayer culture.
Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue Eng Part C Methods. 2010 Aug; 16(4):597-607.
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.
Paruchuri S, Yang JH, Aikawa E, Melero-Martin JM, Khan ZA, Loukogeorgakis S, Schoen FJ, Bischoff J
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Circ Res. 2006 Oct 13; 99(8):861-9.
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2.
Chen YC, Lin RZ, Qi H, Yang Y, Bae H, Melero-Martin JM, Khademhosseini A
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels. Adv Funct Mater. 2012 May 23; 22(10):2027-2039.
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels.
Journal of tissue engineering and regenerative medicine
Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks. J Tissue Eng Regen Med. 2011 Apr; 5(4):e74-86.
Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.
Dudley AC, Udagawa T, Melero-Martin JM, Shih SC, Curatolo A, Moses MA, Klagsbrun M
Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood. 2010 Oct 28; 116(17):3367-71.
Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors.
Lin RZ, Moreno-Luna R, Muñoz-Hernandez R, Li D, Jaminet SC, Greene AK, Melero-Martin JM
Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential. Angiogenesis. 2013 Oct; 16(4):735-44.
Human white adipose tissue vasculature contains endothelial colony-forming cells with robust in vivo vasculogenic potential.