Dr. Murphy’s program in funded basic investigation has been ongoing continuously since 1984 in the form of R01 grants and via participation in Program Project initiatives. The current focus of Dr. Murphy's research is elucidation of the cellular and molecular mechanisms responsible for cutaneous cytotoxic reactions, including graft-versus-host disease subsequent to allogeneic stem cell transplantation for childhood and adult leukemia/lymphoma. In addition, a major collaboration involving Brigham Plastic and Reconstructive Surgery and the MIT Biomaterials Department focuses on tissue stem cell biology and cutaneous regenerative medicine. One goal of this work is to define pathways responsible for scarless regeneration that typifies fetal, but not post-natal, human skin. Dr. Murphy also serves as the Director of the Tissue and Cell Analysis Core for the Harvard Skin Disease Research Center (SDRC) as well as for the Biospecimen Access and Analysis Core for the Harvard Specialized Program for Research Excellence (SPORE) in skin cancer. For research contributions concerning Langerhans cell histiocytosis, he received the Benjamin Castleman Award of the International Academy of Pathology. In 1991, he was elected into the American Society for Clinical Investigation for which he also served as an Institutional Representative. His work in the area of neuropeptide regulation of Langerhans cell function was recognized as one of the 50 most significant scientific breakthroughs worldwide for the year 1993 by the magazine, Discover. His most recent collaborative interaction with the laboratory of Dr. Markus Frank of Boston’s Children’s Hospital has recently fostered the first biomarker identification and therapeutically relevant targeting of melanoma stem cells (January 2008 cover article, Nature). He has served as a regular term member of the General Medicine A Study Section for the NIH.
Gould HJ, Mackay GA, Karagiannis SN, O'Toole CM, Marsh PJ, Daniel BE, Coney LR, Zurawski VR, Joseph M, Capron M, Gilbert M, Murphy GF, Korngold R
Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol. 1999 11; 29(11):3527-37.
Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma.
Harrist TJ, Muhlbauer JE, Murphy GF, Mihm MC, Bhan AK
The Journal of investigative dermatology
T6 is superior to Ia (HLA-DR) as a marker for Langerhans cells and indeterminate cells in normal epidermis: a monoclonal antibody study. J Invest Dermatol. 1983 Feb; 80(2):100-3.
T6 is superior to Ia (HLA-DR) as a marker for Langerhans cells and indeterminate cells in normal epidermis: a monoclonal antibody study.
Sugerman PB, Faber SB, Willis LM, Petrovic A, Murphy GF, Pappo J, Silberstein D, van den Brink MR
Kinetics of gene expression in murine cutaneous graft-versus-host disease. Am J Pathol. 2004 Jun; 164(6):2189-202.
Kinetics of gene expression in murine cutaneous graft-versus-host disease.
Choksi S, Kim JC, Whitaker-Menezes D, Murphy GF, Friedman TM, Korngold R
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model. Biol Blood Marrow Transplant. 2004 Oct; 10(10):669-80.
A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model.
Involucrin expression in normal and neoplastic human skin: a marker for keratinocyte differentiation. J Invest Dermatol. 1984 May; 82(5):453-7.
Involucrin expression in normal and neoplastic human skin: a marker for keratinocyte differentiation.
Murphy GF, Bhan AK, Sato S, Mihm MC, Harrist TJ
A new immunologic marker for human Langerhans cells. N Engl J Med. 1981 Mar 26; 304(13):791-2.
A new immunologic marker for human Langerhans cells.
Oral warty dyskeratoma. Arch Dermatol. 1980 Aug; 116(8):929-31.
Kaminer MS, Murphy GF, Zweiman B, Lavker RM
Clinical and diagnostic laboratory immunology
Connective tissue mast cells exhibit time-dependent degranulation heterogeneity. Clin Diagn Lab Immunol. 1995 May; 2(3):297-301.
Connective tissue mast cells exhibit time-dependent degranulation heterogeneity.
Christofidou-Solomidou M, Albelda SM, Bennett FC, Murphy GF
Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras. Am J Pathol. 1997 Feb; 150(2):631-9.
Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras.
Monteiro MR, Murphy EE, Galaria NA, Whitaker-Menezes D, Murphy GF
Cytological alterations in dermal dendrocytes in vitro: evidence for transformation to a non-dendritic phenotype. Br J Dermatol. 2000 Jul; 143(1):84-90.
Cytological alterations in dermal dendrocytes in vitro: evidence for transformation to a non-dendritic phenotype.
Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. 2018 04 19; 173(3):624-633.e8.
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.
Murphy GF, Lavker RM, Whitaker D, Korngold R
Cytotoxic folliculitis in GvHD. Evidence of follicular stem cell injury and recovery. J Cutan Pathol. 1991 Oct; 18(5):309-14.
Cytotoxic folliculitis in GvHD. Evidence of follicular stem cell injury and recovery.
Zhou J, Yuen NK, Zhan Q, Velazquez EF, Murphy GF, Giobbie-Hurder A, Hodi FS
Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma. Cancer Immunol Immunother. 2012 May; 61(5):655-65.
Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma.
Ringler DJ, Hancock WW, King NW, Letvin NL, Daniel MD, Desrosiers RC, Murphy GF
Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. Am J Pathol. 1987 Feb; 126(2):199-207.
Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome.
Guillén FJ, Hancock WW, Towpik E, Kupiec-Weglinski JW, Rickles FR, Tilney NL, Murphy GF
Inhibition of rat skin allograft rejection by cyclosporine. In situ characterization of the impaired local immune response. Transplantation. 1986 Jun; 41(6):734-9.
Inhibition of rat skin allograft rejection by cyclosporine. In situ characterization of the impaired local immune response.
Autologous melanoma vaccine induces inflammatory responses in melanoma metastases: relevance to immunologic regression and immunotherapy. J Invest Dermatol. 1993 Mar; 100(3):335S-341S.
Autologous melanoma vaccine induces inflammatory responses in melanoma metastases: relevance to immunologic regression and immunotherapy.
Pilewski JM, Yan HC, Juhasz I, Christofidou-Solomidou M, Williams J, Murphy GF, Albelda SM
Modulation of adhesion molecules by cytokines in vivo using human/severe combined immunodeficient (SCID) mouse chimeras. J Clin Immunol. 1995 Nov; 15(6 Suppl):122S-129S.
Modulation of adhesion molecules by cytokines in vivo using human/severe combined immunodeficient (SCID) mouse chimeras.
Durakovic N, Bezak KB, Skarica M, Radojcic V, Fuchs EJ, Murphy GF, Luznik L
Journal of immunology (Baltimore, Md. : 1950)
Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. J Immunol. 2006 Oct 01; 177(7):4414-25.
Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions.
Clinical reviews in allergy & immunology
Target cells in graft-versus-host disease: implications for cancer therapy. Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):113-23.
Target cells in graft-versus-host disease: implications for cancer therapy.
Wang DM, Kraft S, Rohani P, Murphy GF, Besaw RJ, Karia PS, Morgan FC, Schmults CD
Association of Nodal Metastasis and Mortality With Vermilion vs Cutaneous Lip Location in Cutaneous Squamous Cell Carcinoma of the Lip. JAMA Dermatol. 2018 06 01; 154(6):701-707.
Association of Nodal Metastasis and Mortality With Vermilion vs Cutaneous Lip Location in Cutaneous Squamous Cell Carcinoma of the Lip.
Guo Q, Grimmig T, Gonzalez G, Giobbie-Hurder A, Berg G, Carr N, Wilson BJ, Banerjee P, Ma J, Gold JS, Nandi B, Huang Q, Waaga-Gasser AM, Lian CG, Murphy GF, Frank MH, Gasser M, Frank NY
ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer. J Biol Chem. 2018 07 13; 293(28):11166-11178.
ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer.
An erythematous maculopapular eruption in macaques infected with an HTLV-III-like virus (STLV-III). J Invest Dermatol. 1986 Nov; 87(5):674-7.
An erythematous maculopapular eruption in macaques infected with an HTLV-III-like virus (STLV-III).
Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC
Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34.
Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection.
Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, Schulz S, Schanche R, Murphy GF, Waldman SA
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model. J Ultrasound Med. 2011 Apr; 30(4):441-53.
Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model.
Kao HK, Chen B, Murphy GF, Li Q, Orgill DP, Guo L
Peripheral blood fibrocytes: enhancement of wound healing by cell proliferation, re-epithelialization, contraction, and angiogenesis. Ann Surg. 2011 Dec; 254(6):1066-74.
Peripheral blood fibrocytes: enhancement of wound healing by cell proliferation, re-epithelialization, contraction, and angiogenesis.
Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA
Clinical cancer research : an official journal of the American Association for Cancer Research
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013 Mar 01; 19(5):1225-31.
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues. J Cell Biol. 1991 Jun; 113(6):1425-37.
Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues.
Valyi-Nagy IT, Murphy GF, Mancianti ML, Whitaker D, Herlyn M
Laboratory investigation; a journal of technical methods and pathology
Phenotypes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model. Lab Invest. 1990 Mar; 62(3):314-24.
Phenotypes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model.
Oral surgery, oral medicine, and oral pathology
Involucrin as a diagnostic marker in oral lichenoid lesions. Oral Surg Oral Med Oral Pathol. 1987 Sep; 64(3):313-9.
Involucrin as a diagnostic marker in oral lichenoid lesions.
Tonsillar epithelial dendritic cells. Demonstration by lectin binding, immunohistochemical characterization, and ultrastructure. Lab Invest. 1987 Jun; 56(6):622-8.
Tonsillar epithelial dendritic cells. Demonstration by lectin binding, immunohistochemical characterization, and ultrastructure.
Demonstration of T200 on human Langerhans cell surface membranes. J Invest Dermatol. 1984 May; 82(5):535-7.
Demonstration of T200 on human Langerhans cell surface membranes.
Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines. J Cutan Pathol. 1993 Feb; 20(1):21-7.
Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines.
Messadi DV, Pober JS, Fiers W, Gimbrone MA, Murphy GF
Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture. J Immunol. 1987 Sep 01; 139(5):1557-62.
Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture.
Histologic reporting of malignant melanoma. Monogr Pathol. 1988; (30):79-93.
Histologic reporting of malignant melanoma.
Jones SC, Friedman TM, Murphy GF, Korngold R
Specific donor Vbeta-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens. Biol Blood Marrow Transplant. 2004 Feb; 10(2):91-105.
Specific donor Vbeta-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens.
Waldman E, Lu SX, Hubbard VM, Kochman AA, Eng JM, Terwey TH, Muriglan SJ, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR
Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 2006 Feb 15; 107(4):1703-11.
Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine.
Zhan Q, Signoretti S, Whitaker-Menezes D, Friedman TM, Korngold R, Murphy GF
Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype. J Invest Dermatol. 2007 Jan; 127(1):106-15.
Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype.
Wu D, Hu D, Chen H, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018 07; 559(7715):637-641.
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.
Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR
Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol. 2010 Aug 01; 185(3):1912-9.
Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.
Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110.
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin.
Kim TD, Terwey TH, Zakrzewski JL, Suh D, Kochman AA, Chen ME, King CG, Borsotti C, Grubin J, Smith OM, Heller G, Liu C, Murphy GF, Alpdogan O, van den Brink MR
Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood. 2008 Mar 01; 111(5):2929-40.
Organ-derived dendritic cells have differential effects on alloreactive T cells.
Ferrara JL, Marion A, McIntyre JF, Murphy GF, Burakoff SJ
Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody. J Immunol. 1986 Sep 15; 137(6):1874-7.
Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody.
Ringler DJ, Hancock WW, King NW, Murphy GF
Characterization of nonhuman primate epidermal and dermal dendritic cells with monoclonal antibodies. A study of Langerhans cells and indeterminate cells in the rhesus monkey. Lab Invest. 1987 Mar; 56(3):313-20.
Characterization of nonhuman primate epidermal and dermal dendritic cells with monoclonal antibodies. A study of Langerhans cells and indeterminate cells in the rhesus monkey.
Schwartz LB, Foley JV, Austen KF, Soter NA, Shepard R, Murphy GF
The Journal of allergy and clinical immunology
Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody. J Allergy Clin Immunol. 1985 Aug; 76(2 Pt 1):182-8.
Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody.
Journal of the American Academy of Dermatology
Lymphocytes and necrosis of the cutaneous microvasculature in malignant atrophic papulosis: a refined light microscope study. J Am Acad Dermatol. 1982 Nov; 7(5):620-30.
Lymphocytes and necrosis of the cutaneous microvasculature in malignant atrophic papulosis: a refined light microscope study.
Ward C, Volpe G, Cauchy P, Ptasinska A, Almaghrabi R, Blakemore D, Nafria M, Kestner D, Frampton J, Murphy G, Buganim Y, Kaji K, García P
Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming. Cell Rep. 2018 08 07; 24(6):1496-1511.e8.
Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming.
Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Nat Commun. 2018 08 22; 9(1):3368.
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.
Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Lu TT, May C, Scheinberg DA, Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR
Journal of the National Cancer Institute
Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. J Natl Cancer Inst. 2010 Jun 16; 102(12):894-908.
Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth.
Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, van den Brink MR
Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PLoS One. 2011; 6(7):e21611.
Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Transmucosal passage of lentiviruses and the epinodal hypothesis: relevance to the pathogenesis of AIDS. Mod Pathol. 1988 Mar; 1(2):135-9.
Transmucosal passage of lentiviruses and the epinodal hypothesis: relevance to the pathogenesis of AIDS.
Kao HK, Li Q, Flynn B, Qiao X, Ruberti JW, Murphy GF, Guo L
Collagen synthesis modulated in wounds treated by pulsed radiofrequency energy. Plast Reconstr Surg. 2013 Apr; 131(4):490e-498e.
Collagen synthesis modulated in wounds treated by pulsed radiofrequency energy.
Flynn TC, Harrist TJ, Murphy GF, Loss RW, Moschella SL
Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia. J Am Acad Dermatol. 1984 Oct; 11(4 Pt 1):584-90.
Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia.
Epigenetic markers in melanoma. Melanoma Manag. 2015 Nov; 2(4):367-382.
Techniques for the immunoelectron microscopy of Langerhans cells. J Invest Dermatol. 1983 Jul; 81(1):83.
Techniques for the immunoelectron microscopy of Langerhans cells.
Harrist TJ, Fine JD, Berman RS, Murphy GF, Mihm MC
Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy. Arch Dermatol. 1982 Apr; 118(4):263-6.
Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy.
Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Arch Dermatol. 1981 Dec; 117(12):804-8.
Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study.
Griffin TD, Murphy GF, Sueki H, Telegan B, Johnson WC, Ditre CM, Yu RJ, Van Scott EJ
Increased factor XIIIa transglutaminase expression in dermal dendrocytes after treatment with alpha-hydroxy acids: potential physiologic significance. J Am Acad Dermatol. 1996 Feb; 34(2 Pt 1):196-203.
Increased factor XIIIa transglutaminase expression in dermal dendrocytes after treatment with alpha-hydroxy acids: potential physiologic significance.
A Festschrift for Martin C. Mihm, Jr. J Cutan Pathol. 2010 Apr; 37 Suppl 1:1-5.
Gropper AB, Girouard SD, Hojman LP, Huang SJ, Qian X, Murphy GF, Vleugels RA
Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature. J Cutan Pathol. 2012 May; 39(5):526-34.
Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature.
Zhan Q, Korngold R, Lezcano C, McKeon F, Murphy GF
Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells. Biol Blood Marrow Transplant. 2012 Jun; 18(6):841-51.
Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells.
Murphy GF, Austen KF, Fonferko E, Sheffer AL
Morphologically distinctive forms of cutaneous mast cell degranulation induced by cold and mechanical stimuli: an ultrastructural study. J Allergy Clin Immunol. 1987 Oct; 80(4):603-11.
Morphologically distinctive forms of cutaneous mast cell degranulation induced by cold and mechanical stimuli: an ultrastructural study.
Murphy GF, Shepard RS, Harrist TJ, Bronstein BR, Bhan AK
Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringial epithelium. J Invest Dermatol. 1983 Aug; 81(2):181-3.
Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringial epithelium.
Murphy GF, Krusinski PA, Myzak LA, Ershler WB
Local immune response in basal cell carcinoma: characterization by transmission electron microscopy and monoclonal anti-T6 antibody. J Am Acad Dermatol. 1983 Apr; 8(4):477-85.
Local immune response in basal cell carcinoma: characterization by transmission electron microscopy and monoclonal anti-T6 antibody.
Murphy GF, Bhan AK, Sato S, Harrist TJ, Mihm MC
Characterization of Langerhans cells by the use of monoclonal antibodies. Lab Invest. 1981 Nov; 45(5):465-8.
Characterization of Langerhans cells by the use of monoclonal antibodies.
Whitaker-Menezes D, Schechter NM, Murphy GF
Serine proteinases are regionally segregated within mast cell granules. Lab Invest. 1995 Jan; 72(1):34-41.
Serine proteinases are regionally segregated within mast cell granules.
Mast cell degranulation upregulates alpha 6 integrins on epidermal Langerhans cells. J Invest Dermatol. 1993 Aug; 101(2):150-4.
Mast cell degranulation upregulates alpha 6 integrins on epidermal Langerhans cells.
Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS
A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol. 2006 May; 126(5):1059-70.
A novel method for the isolation of skin resident T cells from normal and diseased human skin.
Kollar B, Shubin A, Borges TJ, Tasigiorgos S, Win TS, Lian CG, Dillon ST, Gu X, Wyrobnik I, Murphy GF, Pomahac B, Libermann TA, Riella LV
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Sci Rep. 2018 10 08; 8(1):14915.
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation.
Krezdorn N, Lian CG, Wells M, Wo L, Tasigiorgos S, Xu S, Borges TJ, Frierson RM, Stanek E, Riella LV, Pomahac B, Murphy GF
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Chronic rejection of human face allografts. Am J Transplant. 2019 04; 19(4):1168-1177.
Chronic rejection of human face allografts.
Tong AK, Tan OT, Boll J, Parrish JA, Murphy GF
Ultrastructure: effects of melanin pigment on target specificity using a pulsed dye laser (577 nm). J Invest Dermatol. 1987 Jun; 88(6):747-52.
Ultrastructure: effects of melanin pigment on target specificity using a pulsed dye laser (577 nm).
Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. JCI Insight. 2018 10 18; 3(20).
Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity.
Benign lymph nodes associated with dermatitis presenting as breast masses. Radiology. 1980 Oct; 137(1 Pt 1):15-9.
Benign lymph nodes associated with dermatitis presenting as breast masses.
Sueki H, Whitaker D, Buchsbaum M, Murphy GF
Novel interactions between dermal dendrocytes and mast cells in human skin. Implications for hemostasis and matrix repair. Lab Invest. 1993 Aug; 69(2):160-72.
Novel interactions between dermal dendrocytes and mast cells in human skin. Implications for hemostasis and matrix repair.
de Chadarévian JP, Raphael SA, Murphy GF
Archives of pathology & laboratory medicine
Histologic, ultrastructural, and immunocytochemical features of the granulomas seen in a child with the syndrome of familial granulomatous arthritis, uveitis, and rash. Arch Pathol Lab Med. 1993 Oct; 117(10):1050-2.
Histologic, ultrastructural, and immunocytochemical features of the granulomas seen in a child with the syndrome of familial granulomatous arthritis, uveitis, and rash.
Role of adhesion molecules in cutaneous inflammation and neoplasia. J Cutan Pathol. 1992 Jun; 19(3):161-71.
Role of adhesion molecules in cutaneous inflammation and neoplasia.
Murphy GF, Bronstein BR, Knowles RW, Bhan AK
Ultrastructural documentation of M241 glycoprotein on dendritic and endothelial cells in normal human skin. Lab Invest. 1985 Mar; 52(3):264-9.
Ultrastructural documentation of M241 glycoprotein on dendritic and endothelial cells in normal human skin.
The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. Tissue Eng Part A. 2009 Oct; 15(10):2937-45.
The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells.
Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS
T-cell trafficking plays an essential role in tumor immunity. Lab Invest. 2019 01; 99(1):85-92.
T-cell trafficking plays an essential role in tumor immunity.
Song G, Nguyen DT, Pietramaggiori G, Scherer S, Chen B, Zhan Q, Ogawa R, Yannas IV, Wagers AJ, Orgill DP, Murphy GF
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells. Wound Repair Regen. 2010 Jul-Aug; 18(4):426-32.
Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells.
Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice. Blood. 2018 12 27; 132(26):2763-2774.
Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.
Juhasz I, Lazarus GS, Murphy GF, Shih IM, Herlyn M
Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. J Clin Invest. 1993 Nov; 92(5):2401-7.
Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients.
Juhasz I, Albelda SM, Elder DE, Murphy GF, Adachi K, Herlyn D, Valyi-Nagy IT, Herlyn M
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. Am J Pathol. 1993 Aug; 143(2):528-37.
Growth and invasion of human melanomas in human skin grafted to immunodeficient mice.
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Lab Invest. 1988 Jan; 58(1):61-7.
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Murphy GF, Messadi D, Fonferko E, Hancock WW
Phenotypic transformation of macrophages to Langerhans cells in the skin. Am J Pathol. 1986 Jun; 123(3):401-6.
Phenotypic transformation of macrophages to Langerhans cells in the skin.
Ferrara J, Guillen FJ, Sleckman B, Burakoff SJ, Murphy GF
Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease. J Invest Dermatol. 1986 Apr; 86(4):371-5.
Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease.
Murphy GF, Sanchez NP, Flynn TC, Sanchez JL, Mihm MC, Soter NA
Erythema nodosum leprosum: nature and extent of the cutaneous microvascular alterations. J Am Acad Dermatol. 1986 Jan; 14(1):59-69.
Erythema nodosum leprosum: nature and extent of the cutaneous microvascular alterations.
Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermis. J Invest Dermatol. 1982 Aug; 79(2):85-8.
Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermis.
Berger R, Albelda SM, Berd D, Ioffreda M, Whitaker D, Murphy GF
Expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during melanoma-induced angiogenesis in vivo. J Cutan Pathol. 1993 Oct; 20(5):399-406.
Expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during melanoma-induced angiogenesis in vivo.
Jetté L, Pouliot JF, Murphy GF, Béliveau R
Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein. Biochem J. 1995 Feb 01; 305 ( Pt 3):761-6.
Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein.
Waldorf HA, Walsh LJ, Schechter NM, Murphy GF
Early cellular events in evolving cutaneous delayed hypersensitivity in humans. Am J Pathol. 1991 Feb; 138(2):477-86.
Early cellular events in evolving cutaneous delayed hypersensitivity in humans.
Biochemical studies of immune complexes. II. Purification of immune complexes from sera of patients with malignant melanoma. Clin Immunol Immunopathol. 1983 Mar; 26(3):318-26.
Biochemical studies of immune complexes. II. Purification of immune complexes from sera of patients with malignant melanoma.
Asahina A, Hosoi J, Murphy GF, Granstein RD
Proceedings of the Association of American Physicians
Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function. Proc Assoc Am Physicians. 1995 Jul; 107(2):242-4.
Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function.
DiRienzo CG, Murphy GF, Jones SC, Korngold R, Friedman TM
T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Aug; 12(8):818-27.
T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease.
Murphy GF, Sueki H, Teuscher C, Whitaker D, Korngold R
Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease. J Invest Dermatol. 1994 Apr; 102(4):451-61.
Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease.
Clinical and ultrastructural studies of Romberg's hemifacial atrophy. Plast Reconstr Surg. 1990 May; 85(5):669-74; discussion 675-6.
Clinical and ultrastructural studies of Romberg's hemifacial atrophy.
Ferrara JL, Guillen FJ, van Dijken PJ, Marion A, Murphy GF, Burakoff SJ
Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease. Transplantation. 1989 Jan; 47(1):50-4.
Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease.
Cellular heterogeneity in vertical growth phase melanoma. Arch Pathol Lab Med. 2010 Dec; 134(12):1750-7.
Cellular heterogeneity in vertical growth phase melanoma.
Lu F, Ogawa R, Nguyen DT, Chen B, Guo D, Helm DL, Zhan Q, Murphy GF, Orgill DP
Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes. Ann Plast Surg. 2011 Mar; 66(3):296-300.
Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes.
Girouard SD, Laga AC, Mihm MC, Scolyer RA, Thompson JF, Zhan Q, Widlund HR, Lee CW, Murphy GF
SOX2 contributes to melanoma cell invasion. Lab Invest. 2012 Mar; 92(3):362-70.
SOX2 contributes to melanoma cell invasion.
Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012 Aug 24; 37(2):339-50.
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.
The Journal of dermatologic surgery and oncology
Capsule dermatopathology: nevomelanocytic lesions with spindle cell differentiation. J Dermatol Surg Oncol. 1985 Mar; 11(3):225-30.
Capsule dermatopathology: nevomelanocytic lesions with spindle cell differentiation.
The genesis of paired cisternae during the mitotic cycle. Am J Pathol. 1982 May; 107(2):150-60.
The genesis of paired cisternae during the mitotic cycle.
Dosoretz DE, Raymond AK, Murphy GF, Doppke KP, Schiller AL, Wang CC, Suit HD
Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior. Cancer. 1982 Sep 01; 50(5):1009-14.
Primary lymphoma of bone: the relationship of morphologic diversity to clinical behavior.
Heinonen S, Männikkö M, Klement JF, Whitaker-Menezes D, Murphy GF, Uitto J
Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. J Cell Sci. 1999 Nov; 112 ( Pt 21):3641-8.
Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa.
The skin biopsy and cutaneous medicine: why biopsy the obvious? Skinmed. 2003 Jul-Aug; 2(4):248-50.
The skin biopsy and cutaneous medicine: why biopsy the obvious?
Sharpe RJ, Murphy GF, Whitaker D, Galli SJ, Maione TE
Induction of local inflammation by recombinant human platelet factor 4 in the mouse. Cell Immunol. 1991 Oct 01; 137(1):72-80.
Induction of local inflammation by recombinant human platelet factor 4 in the mouse.
Goldberg BB, Merton DA, Liu JB, Murphy G, Forsberg F
Contrast-enhanced sonographic imaging of lymphatic channels and sentinel lymph nodes. J Ultrasound Med. 2005 Jul; 24(7):953-65.
Contrast-enhanced sonographic imaging of lymphatic channels and sentinel lymph nodes.
Determinants of immune cell trafficking in the skin. Lab Invest. 1990 Nov; 63(5):592-600.
Determinants of immune cell trafficking in the skin.
Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA
Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85.
Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin.
Penack O, Smith OM, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Brandl K, van den Brink MR
NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med. 2009 Sep 28; 206(10):2101-10.
NOD2 regulates hematopoietic cell function during graft-versus-host disease.
Lewis RE, Buchsbaum M, Whitaker D, Murphy GF
Intercellular adhesion molecule expression in the evolving human cutaneous delayed hypersensitivity reaction. J Invest Dermatol. 1989 Nov; 93(5):672-7.
Intercellular adhesion molecule expression in the evolving human cutaneous delayed hypersensitivity reaction.
Ogembo JG, Milner DA, Mansfield KG, Rodig SJ, Murphy GF, Kutok JL, Pinkus GS, Fingeroth JD
SIRPa/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen. J Immunol. 2012 May 01; 188(9):4496-505.
SIRPa/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen.
Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 01; 30(25):e233-6.
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma.
Distribution of cell surface antigens in histiocytosis X cells. Quantitative immunoelectron microscopy using monoclonal antibodies. Lab Invest. 1983 Jan; 48(1):90-7.
Distribution of cell surface antigens in histiocytosis X cells. Quantitative immunoelectron microscopy using monoclonal antibodies.
Bronstein BR, Murphy GF, Harrist TJ, Ruiter DJ, Mihm MC, Bhan AK
Location of HLA-A,B,C antigens in dendritic cells of normal human skin: an immunoelectron microscopic study. J Invest Dermatol. 1983 Jun; 80(6):481-4.
Location of HLA-A,B,C antigens in dendritic cells of normal human skin: an immunoelectron microscopic study.
Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 1993 May 13; 363(6425):159-63.
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide.
Leavitt D, Wells M, Abarzua P, Murphy GF, Lian CG
Differential distribution of the epigenetic marker 5-hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation. J Cutan Pathol. 2019 May; 46(5):327-334.
Differential distribution of the epigenetic marker 5-hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation.
Liu Y, Xu S, Zu T, Li F, Sang S, Liu C, An Y, Mi B, Orgill DP, Murphy GF, Lian CG
Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid. Lab Invest. 2019 07; 99(8):1193-1202.
Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid.
Tappenbeck N, Schröder HM, Niebergall-Roth E, Hassinger F, Dehio U, Dieter K, Kraft K, Kerstan A, Esterlechner J, Frank NY, Scharffetter-Kochanek K, Murphy GF, Orgill DP, Beck J, Frank MH, Ganss C, Kluth MA
In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials. Cytotherapy. 2019 05; 21(5):546-560.
In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials.
Zhong CS, Russell-Goldman E, Murphy GF, Nambudiri VE
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Paraneoplastic Hypomyopathic Dermatomyositis Associated With EGFR Exon-20 Insertion NSCLC. J Thorac Oncol. 2019 Jun; 14(6):e128-e130.
Paraneoplastic Hypomyopathic Dermatomyositis Associated With EGFR Exon-20 Insertion NSCLC.
Edward Wigglesworth Professor of Dermatology
Assistant Professor of Radiation Oncology
Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF
Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation. J Invest Dermatol. 2020 06; 140(6):1266-1275.e3.
Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation.
Kauke M, Safi AF, Zhegibe A, Haug V, Kollar B, Nelms L, Palmer WJ, Tchiloemba B, Lian CG, Murphy GF, Pomahac B
Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review. Transplantation. 2020 12; 104(12):2616-2624.
Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review.
Kollar B, Rizzo NM, Borges TJ, Haug V, Abdulrazzak O, Kauke M, Safi AF, Lian CG, Marty FM, Rutherford AE, Mitchell RN, Murphy GF, Tullius SG, Riella LV, Pomahac B
Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation. Surgery. 2020 06; 167(6):991-998.
Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation.
The Pathobiology of Skin Aging: New Insights into an Old Dilemma. Am J Pathol. 2020 07; 190(7):1356-1369.
The Pathobiology of Skin Aging: New Insights into an Old Dilemma.
Lee CAA, Banerjee P, Wilson BJ, Wu S, Guo Q, Berg G, Karpova S, Mishra A, Lian JW, Tran J, Emmerich M, Murphy GF, Frank MH, Frank NY
Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism. J Biol Chem. 2020 05 29; 295(22):7774-7788.
Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism.
Kerstan A, Niebergall-Roth E, Esterlechner J, Schröder HM, Gasser M, Waaga-Gasser AM, Goebeler M, Rak K, Schrüfer P, Endres S, Hagenbusch P, Kraft K, Dieter K, Ballikaya S, Stemler N, Sadeghi S, Tappenbeck N, Murphy GF, Orgill DP, Frank NY, Ganss C, Scharffetter-Kochanek K, Frank MH, Kluth MA
Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data. Cytotherapy. 2021 02; 23(2):165-175.
Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data.
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, Vignali DAA, Freeman GJ, Sharpe AH
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med. 2021 01 04; 218(1).
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Zu T, Wang D, Xu S, Lee CAA, Zhen E, Yoon CH, Abarzua P, Wang S, Frank NY, Wu X, Lian CG, Murphy GF
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways. Lab Invest. 2021 05; 101(5):636-647.
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways.
COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters). Lab Invest. 2021 03; 101(3):274-279.
COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters).
Digital dermatopathology: The time is now. J Cutan Pathol. 2021 Apr; 48(4):469-471.
Digital dermatopathology: The time is now.
Kauke-Navarro M, Tchiloemba B, Haug V, Kollar B, Diehm Y, Safi AF, Treister NS, Annino DJ, Marty FM, Lian CG, Murphy GF, Pomahac B
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation. J Plast Reconstr Aesthet Surg. 2021 Jul; 74(7):1562-1571.
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation.
Kauke M, Panayi AC, Safi AF, Haug V, Perry B, Kollar B, Nizzi MC, Broyles J, Annino DJ, Marty FM, Sinha I, Lian CG, Murphy GF, Chandraker A, Pomahac B
Full facial retransplantation in a female patient-Technical, immunologic, and clinical considerations. Am J Transplant. 2021 10; 21(10):3472-3480.
Full facial retransplantation in a female patient-Technical, immunologic, and clinical considerations.
Yang J, Lian JW, Chin YH, Wang L, Lian A, Murphy GF, Zhou L
Assessing the Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Melanoma Using Pathologic Features Identified by Natural Language Processing. JAMA Netw Open. 2021 09 01; 4(9):e2126337.
Assessing the Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Melanoma Using Pathologic Features Identified by Natural Language Processing.
Kerstan A, Dieter K, Niebergall-Roth E, Dachtler AK, Kraft K, Stücker M, Daeschlein G, Jünger M, Görge T, Meyer-Pannwitt U, Erfurt-Berge C, von Engelhardt C, Klare A, Pfeiffer C, Esterlechner J, Schröder HM, Gasser M, Waaga-Gasser AM, Goebeler M, Ballikaya S, Sadeghi S, Murphy GF, Orgill DP, Frank NY, Ganss C, Scharffetter-Kochanek K, Frank MH, Kluth MA
JID innovations : skin science from molecules to population health
Allogeneic ABCB5+ mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial. JID Innov. 2022 Jan; 2(1).
Allogeneic ABCB5+ mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial.
Nirmal AJ, Maliga Z, Vallius T, Quattrochi B, Chen AA, Jacobson CA, Pelletier RJ, Yapp C, Arias-Camison R, Chen YA, Lian CG, Murphy GF, Santagata S, Sorger PK
The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution. Cancer Discov. 2022 06 02; 12(6):1518-1541.
The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution.
Borges TJ, Abarzua P, Gassen RB, Kollar B, Lima-Filho M, Aoyama BT, Gluhova D, Clark RA, Islam SA, Pomahac B, Murphy GF, Lian CG, Talbot SG, Riella LV
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation. Cell Rep Med. 2022 03 15; 3(3):100559.
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation.
Grebinoski S, Zhang Q, Cillo AR, Manne S, Xiao H, Brunazzi EA, Tabib T, Cardello C, Lian CG, Murphy GF, Lafyatis R, Wherry EJ, Das J, Workman CJ, Vignali DAA
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat Immunol. 2022 06; 23(6):868-877.
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, Mucciarone K, Heppt MV, Geddes-Sweeney J, Stewart K, Brandenburg A, Liang J, Dimitroff CJ, Mihm MC, Landsberg J, Schlapbach C, Lian CG, Murphy GF, Kupper TS, Ramsey MR, Barthel SR
Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis. Cancer Res. 2022 10 17; 82(20):3774-3784.
Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis.
Chakraborty A, Perez M, Carroll JD, Antonopoulos A, Dell A, Ortega L, Mohammed NBB, Wells M, Staudinger C, Griswold A, Chandler KB, Marrero C, Jimenez R, Tani Y, Wilmott JS, Thompson JF, Wang W, Sackstein R, Scolyer RA, Murphy GF, Haslam SM, Dimitroff CJ
Hypoxia Controls the Glycome Signature and Galectin-8-Ligand Axis to Promote Protumorigenic Properties of Metastatic Melanoma. J Invest Dermatol. 2023 03; 143(3):456-469.e8.
Hypoxia Controls the Glycome Signature and Galectin-8-Ligand Axis to Promote Protumorigenic Properties of Metastatic Melanoma.
Wu M, Matar DY, Yu Z, Chen Z, Knoedler S, Ng B, Darwish OA, Sohrabi S, Friedman L, Haug V, Murphy GF, Rinkevich Y, Orgill DP, Panayi AC
Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing. Pharmaceutics. 2022 Oct 06; 14(10).
Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing.
Sasamoto Y, Lee CAA, Wilson BJ, Buerger F, Martin G, Mishra A, Kiritoshi S, Tran J, Gonzalez G, Hildebrandt F, Jo VY, Lian CG, Murphy GF, Ksander BR, Frank MH, Frank NY
Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation. Cell Rep. 2022 08 09; 40(6):111166.
Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation.
Kerstan A, Dieter K, Niebergall-Roth E, Klingele S, Jünger M, Hasslacher C, Daeschlein G, Stemler L, Meyer-Pannwitt U, Schubert K, Klausmann G, Raab T, Goebeler M, Kraft K, Esterlechner J, Schröder HM, Sadeghi S, Ballikaya S, Gasser M, Waaga-Gasser AM, Murphy GF, Orgill DP, Frank NY, Ganss C, Scharffetter-Kochanek K, Frank MH, Kluth MA
Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers. Stem Cell Res Ther. 2022 09 05; 13(1):455.
Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers.
Mito JK, Weber MC, Corbin A, Murphy GF, Zon LI
Modeling Spitz melanoma in zebrafish using sequential mutagenesis. Dis Model Mech. 2022 08 01; 15(8).
Modeling Spitz melanoma in zebrafish using sequential mutagenesis.
Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA
Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 01 19; 186(2):305-326.e27.
Loss of epigenetic information as a cause of mammalian aging.
Tugwell P, Bombardier C, Gent M, Bennett K, Ludwin D, Grace E, Buchanan WW, Bensen WG, Bellamy N, Murphy GF
Low dose cyclosporine in rheumatoid arthritis: a pilot study. J Rheumatol. 1987 Dec; 14(6):1108-14.
Low dose cyclosporine in rheumatoid arthritis: a pilot study.
ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways. Lab Invest. 2021 May; 101(5):636-647.
COVID-19 and graft-versus-host disease: a tale of two diseases (and why age matters). Lab Invest. 2021 Mar; 101(3):274-279.
Murakami N, Borges TJ, Win TS, Abarzua P, Tasigiorgos S, Kollar B, Barrera V, Ho Sui S, Teague JE, Bueno E, Clark RA, Lian CG, Murphy GF, Pomahac B, Riella LV
Low-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study. Am J Transplant. 2023 04; 23(4):549-558.
Low-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study.
Maliga Z, Kim DY, Bui AN, Lin JR, Dewan AK, Murphy GF, Nirmal AJ, Lian CG, Sorger PK, LeBoeuf NR
bioRxiv : the preprint server for biology
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence. bioRxiv. 2023 Apr 05.
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence.
Lee CAA, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone KN, Sohrabi S, Lian CG, Pomahac B, Murphy GF
Insights from immunoproteomic profiling of a rejected full-face transplant. Am J Transplant. 2023 07; 23(7):1058-1061.
Insights from immunoproteomic profiling of a rejected full-face transplant.
Knoedler L, Knoedler S, Panayi AC, Lee CAA, Sadigh S, Huelsboemer L, Stoegner VA, Schroeter A, Kern B, Mookerjee V, Lian CG, Tullius SG, Murphy GF, Pomahac B, Kauke-Navarro M
Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Front Immunol. 2023; 14:1179355.
Cellular activation pathways and interaction networks in vascularized composite allotransplantation.
Collier JL, Pauken KE, Lee CAA, Patterson DG, Markson SC, Conway TS, Fung ME, France JA, Mucciarone KN, Lian CG, Murphy GF, Sharpe AH
Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice. J Exp Med. 2023 10 02; 220(10).
Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice.
Yapp C, Nirmal AJ, Zhou F, Wong AYH, Tefft JB, Lu YD, Shang Z, Maliga Z, Llopis PM, Murphy GF, Lian CG, Danuser G, Santagata S, Sorger PK
Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours. bioRxiv. 2025 Apr 11.
Highly Multiplexed 3D Profiling of Cell States and Immune Niches in Human Tumours.
Martins C, Rasbach E, Heppt MV, Singh P, Kulcsar Z, Holzgruber J, Chakraborty A, Mucciarone K, Kleffel S, Brandenburg A, Hoetzenecker W, Rahbari NN, DeCaprio JA, Thakuria M, Murphy GF, Ramsey MR, Posch C, Barthel SR, Schatton T
Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling. Sci Adv. 2024 01 19; 10(3):eadi2012.
Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling.
Skin-Intrinsic Immunosuppressive Mesenchymal Stem Cells and aGVHD
Multicomponent Therapy for Age-related Skin Stem Cell Deficiency
Maliga Z, Kim DY, Bui AN, Lin JR, Dewan AK, Jadeja S, Murphy GF, Nirmal AJ, Lian CG, Sorger PK, LeBoeuf NR
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade Using Tissue Cyclic Immunofluorescence: A Pilot Study. J Invest Dermatol. 2024 Aug; 144(8):1887-1890.e5.
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade Using Tissue Cyclic Immunofluorescence: A Pilot Study.
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Stem cells and cancer: a deadly mix. Cell Tissue Res. 2008 Jan; 331(1):109-24.
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Systematic review of molecular mechanism of action of negative-pressure wound therapy. Br J Surg. 2014 Dec; 101(13):1627-36.
Systematic review of molecular mechanism of action of negative-pressure wound therapy.
Murphy G, Markeson D, Choa R, Armstrong A
Raised serum lactate: a marker of necrotizing fasciitis? J Plast Reconstr Aesthet Surg. 2013 Dec; 66(12):1712-6.
Raised serum lactate: a marker of necrotizing fasciitis?
Lin RL, Wang TJ, Joyce CJ, Mihm MC, Murphy GF, Lian CG, Lin JY
Decreased tumor-infiltrating lymphocytes in nodular melanomas compared with matched superficial spreading melanomas. Melanoma Res. 2016 10; 26(5):524-7.
Decreased tumor-infiltrating lymphocytes in nodular melanomas compared with matched superficial spreading melanomas.
Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update. Dermatopathology (Basel). 2015 Jan-Mar; 2(1):15-42.
Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An Update.
Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016 Apr 08; 352(6282):189-96.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
Chandraker A, Arscott R, Murphy G, Lian C, Bueno E, Marty F, Rennke H, Milford E, Tullius S, Pomahac B
Face Transplantation in a Highly Sensitized Recipient. Mil Med. 2016 05; 181(5 Suppl):221-6.
Face Transplantation in a Highly Sensitized Recipient.
Gomes CB, Zechin KG, Xu S, Stelini RF, Nishimoto IN, Zhan Q, Xu T, Qin G, Treister NS, Murphy GF, Lian CG
TET2 Negatively Regulates Nestin Expression in Human Melanoma. Am J Pathol. 2016 06; 186(6):1427-34.
TET2 Negatively Regulates Nestin Expression in Human Melanoma.
Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Sci Transl Med. 2016 05 18; 8(339):339ra71.
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Obaitan I, Dwyer R, Lipworth AD, Kupper TS, Camargo CA, Hooper DC, Murphy GF, Pallin DJ
The American journal of emergency medicine
Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis. Am J Emerg Med. 2016 Aug; 34(8):1645-52.
Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis.
Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66.
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
Immunology of human malignant melanoma initiating cells
Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma
BIOLOGIC &CLINICAL PROPERTIES OF CD4 STRUCTURAL ANALOGS
Cellular Pathology of Graft Versus Host Disease
CELLULAR PATHOLOGY OF GRAFT VERSUS HOST DISEASE
Synergies among inhibitory receptors in tolerance, cancer and antiviral immunity
Immune Modulation/Hematopoietic Cell Transplantation
Clark SL, Tse JY, Fisher DC, LeBeouf NR, Murphy GF, Kupper TS, Clark RA, Lian CG
Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab). J Cutan Pathol. 2016 Nov; 43(11):989-993.
Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab).
Hendrix MJ, Kandela I, Mazar AP, Seftor EA, Seftor RE, Margaryan NV, Strizzi L, Murphy GF, Long GV, Scolyer RA
Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells. Lab Invest. 2017 02; 97(2):176-186.
Targeting melanoma with front-line therapy does not abrogate Nodal-expressing tumor cells.
Face Transplantation in a Highly Sensitized Recipient. Mil Med. 2016 10; 181(10):1392.
Bresler SC, Min L, Rodig SJ, Walls AC, Xu S, Geng S, Hodi FS, Murphy GF, Lian CG
Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity. Lab Invest. 2017 02; 97(2):207-216.
Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity.
Pallin DJ, Bry L, Dwyer RC, Lipworth AD, Leung DY, Camargo CA, Kupper TS, Filbin MR, Murphy GF
Toward an Objective Diagnostic Test for Bacterial Cellulitis. PLoS One. 2016; 11(9):e0162947.
Toward an Objective Diagnostic Test for Bacterial Cellulitis.
Lee JJ, Vilain RE, Granter SR, Hu NR, Bresler SC, Xu S, Frank AH, Mihm MC, Saw RP, Fletcher CD, Scolyer RA, Murphy GF, Lian CG
5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms. J Cutan Pathol. 2017 Mar; 44(3):249-255.
5-Hydroxymethylcytosine is a nuclear biomarker to assess biological potential in histologically ambiguous heavily pigmented melanocytic neoplasms.
Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. Nat Med. 2017 Feb; 23(2):242-249.
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.
United States/Canadian Academy of Pathology
American Society for Clinical Investigation
International League of Dermatologic Societies
University of Pennsylvania School of Medicine
Distinguished Academic Achievement Award
Quest Visiting Professorship in Pathology
Royal College of Physicians and Surgeons of Canada
American Society of Clinical Pathologists
Whitaker Health Sciences Foundation Award
University of Vermont, College of Medicine
A story of mice and men: SCID mouse-human skin chimeras in immunology research. J Invest Dermatol. 1996 Oct; 107(4):529-30.
A story of mice and men: SCID mouse-human skin chimeras in immunology research.
Gilliam AC, Whitaker-Menezes D, Korngold R, Murphy GF
Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease. J Invest Dermatol. 1996 Sep; 107(3):377-83.
Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease.
Wallace H. Clark, Jr., MD: a biography and annotated bibliography. Hum Pathol. 1999 May; 30(5):491-7.
Wallace H. Clark, Jr., MD: a biography and annotated bibliography.
Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon JJ, van den Brink MR
T cells require TRAIL for optimal graft-versus-tumor activity. Nat Med. 2002 Dec; 8(12):1433-7.
T cells require TRAIL for optimal graft-versus-tumor activity.
Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D, Murphy GF
Proceedings of the National Academy of Sciences of the United States of America
Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4220-4.
Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1.
Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MR
CCR2 is required for CD8-induced graft-versus-host disease. Blood. 2005 Nov 01; 106(9):3322-30.
CCR2 is required for CD8-induced graft-versus-host disease.
Egan CL, Viglione-Schneck MJ, Walsh LJ, Green B, Trojanowski JQ, Whitaker-Menezes D, Murphy GF
Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and murine skin. J Cutan Pathol. 1998 Jan; 25(1):20-9.
Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and murine skin.
Walsh LJ, Goerdt S, Pober JS, Sueki H, Murphy GF
MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells. Lab Invest. 1991 Dec; 65(6):732-41.
MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells.
Jones SC, Murphy GF, Friedman TM, Korngold R
Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model. J Clin Invest. 2003 Dec; 112(12):1880-6.
Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model.
Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis. Br J Dermatol. 1992 Sep; 127(3):239-46.
Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis.
Yoo YH, Gilliam AC, Whitaker-Menezes D, Korngold R, Murphy GF
Experimental induction and ultrastructural characterization of apoptosis in murine acute cutaneous graft-versus-host disease. Arch Dermatol Res. 1997 Jun; 289(7):389-98.
Experimental induction and ultrastructural characterization of apoptosis in murine acute cutaneous graft-versus-host disease.
Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi. Hum Pathol. 1999 May; 30(5):506-12.
Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi.
Monteiro MR, Shapiro SS, Takafuta T, Menezes DW, Murphy GF
Von Willebrand factor receptor GPIb alpha is expressed by human factor XIIIa-positive dermal dendrocytes and is upregulated by mast cell degranulation. J Invest Dermatol. 1999 Aug; 113(2):272-6.
Von Willebrand factor receptor GPIb alpha is expressed by human factor XIIIa-positive dermal dendrocytes and is upregulated by mast cell degranulation.
Mechanism of apoptotic regulation of follicular regression: toward understanding the molecular basis for tissue remodeling and regeneration. Am J Pathol. 2001 Jun; 158(6):1899-901.
Mechanism of apoptotic regulation of follicular regression: toward understanding the molecular basis for tissue remodeling and regeneration.
The translational basis of human cutaneous photoaging: on models, methods, and meaning. Am J Pathol. 2009 Feb; 174(2):357-60.
The translational basis of human cutaneous photoaging: on models, methods, and meaning.
Dysplastic melanocytic nevi and prognostically indeterminate nevomelanomatoid proliferations. Clin Lab Med. 2000 Dec; 20(4):691-712.
Dysplastic melanocytic nevi and prognostically indeterminate nevomelanomatoid proliferations.
Townsend RM, Briggs C, Marini JC, Murphy GF, Korngold R
Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier. Blood. 1996 Oct 15; 88(8):3038-47.
Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier.
Kaminer MS, Lavker RM, Walsh LJ, Whitaker D, Zweiman B, Murphy GF
Extracellular localization of human connective tissue mast cell granule contents. J Invest Dermatol. 1991 Jun; 96(6):857-63.
Extracellular localization of human connective tissue mast cell granule contents.
Friedman TM, Statton D, Jones SC, Berger MA, Murphy GF, Korngold R
Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with epithelial tissue infiltrate. Biol Blood Marrow Transplant. 2001; 7(1):2-13.
Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with epithelial tissue infiltrate.
Ultrastructure and dynamics of selective mitochondrial injury in carcinoma cells after doxycycline photosensitization in vitro. Am J Pathol. 1988 Nov; 133(2):381-8.
Ultrastructure and dynamics of selective mitochondrial injury in carcinoma cells after doxycycline photosensitization in vitro.
Kim JC, Whitaker-Menezes D, Deguchi M, Adair BS, Korngold R, Murphy GF
Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease. Am J Pathol. 2002 Sep; 161(3):763-70.
Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease.
Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR
Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 02; 137(5):1091-102.
Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.
Topical tretinoin replenishes CD1a-positive epidermal Langerhans cells in chronically photodamaged human skin. J Cutan Pathol. 1998 Jan; 25(1):30-4.
Topical tretinoin replenishes CD1a-positive epidermal Langerhans cells in chronically photodamaged human skin.
Primary sweat gland carcinosarcoma of the scrotal skin. J Cutan Pathol. 2004 Nov; 31(10):678-82.
Primary sweat gland carcinosarcoma of the scrotal skin.
Hairless micropig skin. A novel model for studies of cutaneous biology. Am J Pathol. 1991 Mar; 138(3):687-97.
Hairless micropig skin. A novel model for studies of cutaneous biology.
Alvarez F, Atkison PR, Grant DR, Guilbault N, Jones AB, Kim PS, Kneteman NM, Laurin L, Martin SR, Murphy GF, Paradis K, Shapiro J, Smith LJ, Superina RA
NOF-11: a one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation. Transplantation. 2000 Jan 15; 69(1):87-92.
NOF-11: a one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation.
Whitaker-Menezes D, Jones SC, Friedman TM, Korngold R, Murphy GF
An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression. Biol Blood Marrow Transplant. 2003 Sep; 9(9):559-70.
An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression.
Korngold R, Jameson BA, McDonnell JM, Leighton C, Sutton BJ, Gould HJ, Murphy GF
Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease. Biol Blood Marrow Transplant. 1997 Oct; 3(4):187-93.
Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease.
Cytotoxic T lymphocytes and phenotypically abnormal epidermal dendritic cells in fixed cutaneous eruptions. Hum Pathol. 1985 Dec; 16(12):1264-71.
Cytotoxic T lymphocytes and phenotypically abnormal epidermal dendritic cells in fixed cutaneous eruptions.
Tian T, Jin MQ, Dubin K, King SL, Hoetzenecker W, Murphy GF, Chen CA, Kupper TS, Fuhlbrigge RC
IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection. J Immunol. 2017 06 01; 198(11):4341-4351.
IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection.
Burkert KL, Huhn K, Menezes DW, Murphy GF
Langerhans cell microgranulomas (pseudo-pautrier abscesses): morphologic diversity, diagnostic implications and pathogenetic mechanisms. J Cutan Pathol. 2002 Oct; 29(9):511-6.
Langerhans cell microgranulomas (pseudo-pautrier abscesses): morphologic diversity, diagnostic implications and pathogenetic mechanisms.
Melanoma stem cells: not rare, but well done. Lab Invest. 2011 May; 91(5):647-64.
Melanoma stem cells: not rare, but well done.
Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. J Invest Dermatol. 1990 Apr; 94(4):492-5.
Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium.
Schmaltz C, Alpdogan O, Muriglan SJ, Kappel BJ, Rotolo JA, Ricchetti ET, Greenberg AS, Willis LM, Murphy GF, Crawford JM, van den Brink MR
Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood. 2003 Mar 15; 101(6):2440-5.
Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation.
Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transplant. 2003 Apr; 9(4):243-56.
Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response.
Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications. Hum Pathol. 2003 Nov; 34(11):1216-20.
Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications.
Friedman TM, Jones SC, Statton D, Murphy GF, Korngold R
Evolution of responding CD4+ and CD8+ T-cell repertoires during the development of graft-versus-host disease directed to minor histocompatibility antigens. Biol Blood Marrow Transplant. 2004 Apr; 10(4):224-35.
Evolution of responding CD4+ and CD8+ T-cell repertoires during the development of graft-versus-host disease directed to minor histocompatibility antigens.
Yannas IV, Lee E, Orgill DP, Skrabut EM, Murphy GF
Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):933-7.
Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin.
Wu X, Li J, Connolly EM, Liao X, Ouyang J, Giobbie-Hurder A, Lawrence D, McDermott D, Murphy G, Zhou J, Piesche M, Dranoff G, Rodig S, Shipp M, Hodi FS
Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes. Cancer Immunol Res. 2017 06; 5(6):446-454.
Combined Anti-VEGF and Anti-CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes.
Christofidou-Solomidou M, Longley BJ, Whitaker-Menezes D, Albelda SM, Murphy GF
Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia. J Invest Dermatol. 1997 Jul; 109(1):102-7.
Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia.
Malignant melanoma in situ: an oxymoron whose time has come. Hum Pathol. 1998 Jan; 29(1):6-7.
Malignant melanoma in situ: an oxymoron whose time has come.
DiRienzo CG, Murphy GF, Friedman TM, Korngold R
T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens. Biol Blood Marrow Transplant. 2007 Mar; 13(3):265-76.
T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.
Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N, Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR
IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. J Immunol. 2007 Aug 01; 179(3):1669-80.
IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease.
Mirowski G, Austen KF, Chiang L, Horan RF, Sheffer AL, Weidner N, Murphy GF
Characterization of cellular dermal infiltrates in human cutaneous mastocytosis. Lab Invest. 1990 Jul; 63(1):52-62.
Characterization of cellular dermal infiltrates in human cutaneous mastocytosis.
Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8.
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus.
Merot Y, Mazoujian G, Pinkus G, Momtaz-T K, Murphy GF
Extramammary Paget's disease of the perianal and perineal regions. Evidence of apocrine derivation. Arch Dermatol. 1985 Jun; 121(6):750-2.
Extramammary Paget's disease of the perianal and perineal regions. Evidence of apocrine derivation.
Rothberg BE, Moeder CB, Kluger H, Halaban R, Elder DE, Murphy GF, Lazar A, Prieto V, Duncan LM, Rimm DL
Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions. Mod Pathol. 2008 Sep; 21(9):1121-9.
Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions.
Ding W, Beissert S, Deng L, Miranda E, Cassetty C, Seiffert K, Campton KL, Yan Z, Murphy GF, Bluestone JA, Granstein RD
Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis. J Clin Invest. 2003 Jun; 111(12):1923-31.
Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis.
Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34.
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
Granstein RD, Murphy GF, Margolis RJ, Byrne MH, Amento EP
Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J Clin Invest. 1987 Apr; 79(4):1254-8.
Gamma-interferon inhibits collagen synthesis in vivo in the mouse.
Erba P, Ogawa R, Ackermann M, Adini A, Miele LF, Dastouri P, Helm D, Mentzer SJ, D'Amato RJ, Murphy GF, Konerding MA, Orgill DP
Angiogenesis in wounds treated by microdeformational wound therapy. Ann Surg. 2011 Feb; 253(2):402-9.
Angiogenesis in wounds treated by microdeformational wound therapy.
Win TS, Murakami N, Borges TJ, Chandraker A, Murphy G, Lian C, Barrera V, Ho Sui S, Schoenfeld D, Teague J, Bueno E, Tullius SG, Pomahac B, Clark RA, Riella LV
Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight. 2017 Jul 06; 2(13).
Longitudinal immunological characterization of the first presensitized recipient of a face transplant.
Hu S, Cohen D, Murphy G, Mody E, Qureshi AA
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. Cutis. 2008 Apr; 81(4):336-8.
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept.
Murphy GF, Shepard RS, Paul BS, Menkes A, Anderson RR, Parrish JA
Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation. Lab Invest. 1983 Dec; 49(6):680-5.
Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation.
Langerhans' cells and identification with antibodies. Arch Pathol Lab Med. 1982 May; 106(5):255-6.
Langerhans' cells and identification with antibodies.
Merot Y, Gravallese E, Guillén FJ, Murphy GF
Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case. Arch Dermatol. 1986 Apr; 122(4):455-8.
Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case.
van den Brink MR, Moore E, Horndasch KJ, Crawford JM, Murphy GF, Burakoff SJ
Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease. Transplantation. 2000 Jul 15; 70(1):184-91.
Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.
Klein LM, Lavker RM, Matis WL, Murphy GF
Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8972-6.
Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.
Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009 Sep; 124(3):485-93, 493.e1.
Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen.
Cytokeratin typing of cutaneous tumors: a new immunochemical probe for cellular differentiation and malignant transformation. J Invest Dermatol. 1985 Jan; 84(1):1-2.
Cytokeratin typing of cutaneous tumors: a new immunochemical probe for cellular differentiation and malignant transformation.
Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP
Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. PLoS One. 2010 Nov 15; 5(11):e13973.
Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice.
Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26; 6(1):e16245.
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity.
Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH
Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res. 2010 Jan 15; 70(2):697-708.
Modulation of T-cell activation by malignant melanoma initiating cells.
McAllister JC, Zhan Q, Weishaupt C, Hsu MY, Murphy GF
The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts. J Cutan Pathol. 2010 Apr; 37 Suppl 1:19-25.
The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts.
Cuevas-Nunez MC, Gomes CBF, Woo SB, Ramsey MR, Chen XL, Xu S, Xu T, Zhan Q, Murphy GF, Lian CG
Oral surgery, oral medicine, oral pathology and oral radiology
Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jan; 125(1):59-73.e2.
Oral Surg Oral Med Oral Pathol Oral Radiol
Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
Cell membrane glycoproteins and Langerhans cells. Hum Pathol. 1985 Feb; 16(2):103-12.
Cell membrane glycoproteins and Langerhans cells.
Harrist TJ, Bhan AK, Murphy GF, Sato S, Berman RS, Gellis SE, Freedman S, Mihm MC
Histiocytosis-X: in situ characterization of cutaneous infiltrates with monoclonal antibodies. Am J Clin Pathol. 1983 Mar; 79(3):294-300.
Histiocytosis-X: in situ characterization of cutaneous infiltrates with monoclonal antibodies.
Skin pharmacology and applied skin physiology
cis-urocanic acid induces mast cell degranulation and release of preformed TNF-alpha: A possible mechanism linking UVB and cis-urocanic acid to immunosuppression of contact hypersensitivity. Skin Pharmacol Appl Skin Physiol. 1999 Jan-Apr; 12(1-2):18-27.
cis-urocanic acid induces mast cell degranulation and release of preformed TNF-alpha: A possible mechanism linking UVB and cis-urocanic acid to immunosuppression of contact hypersensitivity.
Significance of selectively targeted apoptotic rete cells in graft-versus-host disease. Biol Blood Marrow Transplant. 2004 Jun; 10(6):357-65.
Significance of selectively targeted apoptotic rete cells in graft-versus-host disease.
Laga AC, Lai CY, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu MY, Murphy GF
Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. Am J Pathol. 2010 Feb; 176(2):903-13.
Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology.
Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85.
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth.
Longley BJ, Tyrrell L, Lu S, Ma Y, Klump V, Murphy GF
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments. J Invest Dermatol. 1997 May; 108(5):792-6.
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
Adrian RM, Murphy GF, Sato S, Granstein RD, Fitzpatrick TB, Sober AJ
Diffuse melanosis secondary to metastatic malignant melanoma. Light and electron microscopic findings. J Am Acad Dermatol. 1981 Sep; 5(3):308-18.
Diffuse melanosis secondary to metastatic malignant melanoma. Light and electron microscopic findings.
Christofidou-Solomidou M, Murphy GF, Albelda SM
Induction of E-selectin-dependent leukocyte recruitment by mast cell degranulation in human skin grafts transplanted on SCID mice. Am J Pathol. 1996 Jan; 148(1):177-88.
Induction of E-selectin-dependent leukocyte recruitment by mast cell degranulation in human skin grafts transplanted on SCID mice.
Murphy GF, Whitaker D, Sprent J, Korngold R
Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells. Am J Pathol. 1991 Apr; 138(4):983-90.
Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells.
Deguchi M, Whitaker-Menezes D, Jones SC, Aiba S, Nakagawa S, Tagami H, Korngold R, Murphy GF
12E2: a cloned murine dermal cell with features of dermal dendrocytes and capacity to produce pathologic changes resembling early Kaposi's sarcoma. Am J Pathol. 2003 Nov; 163(5):1817-25.
12E2: a cloned murine dermal cell with features of dermal dendrocytes and capacity to produce pathologic changes resembling early Kaposi's sarcoma.
Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22; 114(17):3693-706.
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.
Hsu MY, Rovinsky SA, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF
Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest. 2008 Aug; 88(8):842-55.
Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation.
Li Q, Kao H, Matros E, Peng C, Murphy GF, Guo L
Pulsed radiofrequency energy accelerates wound healing in diabetic mice. Plast Reconstr Surg. 2011 Jun; 127(6):2255-2262.
Pulsed radiofrequency energy accelerates wound healing in diabetic mice.
Goldberg BB, Merton DA, Liu JB, Thakur M, Murphy GF, Needleman L, Tornes A, Forsberg F
Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US. Radiology. 2004 Mar; 230(3):727-34.
Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US.
Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Muriglan SJ, Kochman AA, Terwey TH, Willis LM, Schiro R, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR
Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation. Blood. 2005 Nov 01; 106(9):3285-92.
Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Mast cells and dendritic cells in basal cell carcinoma stroma. Dermatol Surg. 2000 Mar; 26(3):200-3; discussion 203-4.
Mast cells and dendritic cells in basal cell carcinoma stroma.
Baron JA, Monzon F, Galaria N, Murphy GF
Angiomatoid melanoma: a novel pattern of differentiation in invasive periocular desmoplastic malignant melanoma. Hum Pathol. 2000 Dec; 31(12):1520-2.
Angiomatoid melanoma: a novel pattern of differentiation in invasive periocular desmoplastic malignant melanoma.
Guillén FJ, Ferrara J, Hancock WW, Messadi D, Fonferko E, Burakoff SJ, Murphy GF
Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in a murine model. Evidence that large granular lymphocytes are effector cells in the immune response. Lab Invest. 1986 Jul; 55(1):35-42.
Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in a murine model. Evidence that large granular lymphocytes are effector cells in the immune response.
Murphy GF, Merot Y, Tong AK, Smith B, Mihm MC
Depletion and repopulation of epidermal dendritic cells after allogeneic bone marrow transplantation in humans. J Invest Dermatol. 1985 Mar; 84(3):210-4.
Depletion and repopulation of epidermal dendritic cells after allogeneic bone marrow transplantation in humans.
Smith SB, Harrist TJ, Murphy GF, Halperin AJ, Newell JB, Fallon JT, Fine JD, Mihm MC
Linear IgA bullous dermatosis v dermatitis herpetiformis. Quantitative measurements of dermoepidermal alterations. Arch Dermatol. 1984 Mar; 120(3):324-8.
Linear IgA bullous dermatosis v dermatitis herpetiformis. Quantitative measurements of dermoepidermal alterations.
Yan HC, Juhasz I, Pilewski J, Murphy GF, Herlyn M, Albelda SM
Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules. J Clin Invest. 1993 Mar; 91(3):986-96.
Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules.
Korngold R, Marini JC, de Baca ME, Murphy GF, Giles-Komar J
Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses. Biol Blood Marrow Transplant. 2003 May; 9(5):292-303.
Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses.
Walsh LJ, Kaminer MS, Lazarus GS, Lavker RM, Murphy GF
Role of laminin in localization of human dermal mast cells. Lab Invest. 1991 Oct; 65(4):433-40.
Role of laminin in localization of human dermal mast cells.
Motta A, Zhan Q, Larson A, Lerman M, Woo SB, Soiffer RJ, Murphy GF, Treister NS
Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study. Oral Dis. 2018 May; 24(4):580-590.
Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study.
Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46.
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58.
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
Polla LL, Margolis RJ, Dover JS, Whitaker D, Murphy GF, Jacques SL, Anderson RR
Melanosomes are a primary target of Q-switched ruby laser irradiation in guinea pig skin. J Invest Dermatol. 1987 Sep; 89(3):281-6.
Melanosomes are a primary target of Q-switched ruby laser irradiation in guinea pig skin.
Parrish JA, Anderson RR, Harrist T, Paul B, Murphy GF
Selective thermal effects with pulsed irradiation from lasers: from organ to organelle. J Invest Dermatol. 1983 Jun; 80 Suppl:75s-80s.
Selective thermal effects with pulsed irradiation from lasers: from organ to organelle.
T cell subsets and Langerhans cells in lichen planus: in situ characterization using monoclonal antibodies. Br J Dermatol. 1981 Dec; 105(6):617-22.
T cell subsets and Langerhans cells in lichen planus: in situ characterization using monoclonal antibodies.
Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycan grafts. Lab Invest. 1990 Mar; 62(3):305-13.
Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycan grafts.
Tucker DW, Getchell CR, McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir A, Medina JE, Lee JJ, MacDonald LA, Malik A, Hasselblatt KT, Li W, Zhang H, Kaplan SJ, Murphy GF, Hirsch MS, Liu JF, Matulonis UA, Terry KL, Lian CG, Dinulescu DM
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer. Clin Cancer Res. 2018 03 15; 24(6):1389-1401.
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.
Selective thermal effects with pulsed irradiation from lasers: from organ to organelle. J Invest Dermatol. 1983 Jun; 80(1 Suppl):75s-80s.
Granstein RD, Askari M, Whitaker D, Murphy GF
Epidermal cells in activation of suppressor lymphocytes: further characterization. J Immunol. 1987 Jun 15; 138(12):4055-62.
Epidermal cells in activation of suppressor lymphocytes: further characterization.
Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH
Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.
Identification of cells initiating human melanomas.
Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts. J Cutan Pathol. 2008 Jul; 35(7):615-22.
Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts.
Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF
SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011 Apr; 20(4):339-45.
SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study.
Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM
Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis. 2012 Oct; 29(7):775-96.
Progression of cutaneous melanoma: implications for treatment.
Dysplastic nevus: a formal histogenetic precursor of malignant melanoma. Monogr Pathol. 1988; (30):10-8.
Dysplastic nevus: a formal histogenetic precursor of malignant melanoma.
Sheffer AL, Tong AK, Murphy GF, Lewis RA, McFadden ER, Austen KF
Exercise-induced anaphylaxis: a serious form of physical allergy associated with mast cell degranulation. J Allergy Clin Immunol. 1985 Apr; 75(4):479-84.
Exercise-induced anaphylaxis: a serious form of physical allergy associated with mast cell degranulation.
In situ identification of T6-positive cells in normal human dermis by immunoelectron microscopy. Br J Dermatol. 1983 Apr; 108(4):423-31.
In situ identification of T6-positive cells in normal human dermis by immunoelectron microscopy.
Sato S, Murphy GF, Bernhard JD, Mihm MC, Fitzpatrick TB
Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin. J Invest Dermatol. 1981 Sep; 77(3):264-71.
Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin.
Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9.
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Martin JE, Wagner AJ, Murphy GF, Pinkus GS, Wang LC
Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma. J Clin Oncol. 2009 Nov 01; 27(31):e168-71.
Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma.
Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Stephen Hodi F, Frank NY, Frank MH
Biochemical and biophysical research communications
Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun. 2010 Nov 26; 402(4):711-7.
Isolation of tumorigenic circulating melanoma cells.
Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY
ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res. 2011 Aug 01; 71(15):5307-16.
ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients.
Peng C, Chen B, Kao HK, Murphy G, Orgill DP, Guo L
Lack of FGF-7 further delays cutaneous wound healing in diabetic mice. Plast Reconstr Surg. 2011 Dec; 128(6):673e-684e.
Lack of FGF-7 further delays cutaneous wound healing in diabetic mice.
Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb; 132(2):410-20.
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.
Weiss RR, Whitaker-Menezes D, Longley J, Bender J, Murphy GF
Human dermal endothelial cells express membrane-associated mast cell growth factor. J Invest Dermatol. 1995 Jan; 104(1):101-6.
Human dermal endothelial cells express membrane-associated mast cell growth factor.
Computer-assisted three-dimensional reconstruction of human dermal dendrocytes. J Invest Dermatol. 1995 Nov; 105(5):704-8.
Computer-assisted three-dimensional reconstruction of human dermal dendrocytes.
Juhasz I, Murphy GF, Yan HC, Herlyn M, Albelda SM
Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol. 1993 Nov; 143(5):1458-69.
Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo.
Wayner EA, Gil SG, Murphy GF, Wilke MS, Carter WG
Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes. J Cell Biol. 1993 Jun; 121(5):1141-52.
Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes.
Volpicelli ER, Doyle L, Annes JP, Murray MF, Jacobsen E, Murphy GF, Saavedra AP
Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol. 2011 Mar; 38(3):280-5.
Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review.
Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy GF, Leonard WJ, Heller G, van den Brink MR
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011 Jul 14; 118(2):446-55.
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.
Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha. J Biol Chem. 1998 Jul 10; 273(28):17531-8.
Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.
Sueki H, Miller SJ, Dzubow LM, Murphy GF
Eccrine syringofibroadenoma (Mascaro): an ultrastructural study. J Cutan Pathol. 1992 Jun; 19(3):232-9.
Eccrine syringofibroadenoma (Mascaro): an ultrastructural study.
Christofidou-Solomidou M, Bridges M, Murphy GF, Albelda SM, DeLisser HM
Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. Am J Pathol. 1997 Oct; 151(4):975-83.
Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras.
Yoo YH, Park BS, Whitaker-Menezes D, Korngold R, Murphy GF
Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease. J Cutan Pathol. 1998 Sep; 25(8):426-34.
Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease.
Roosje PJ, Whitaker-Menezes D, Goldschmidt MH, Moore PF, Willemse T, Murphy GF
Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis. Am J Pathol. 1997 Oct; 151(4):927-32.
Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis.
Murphy GF, Fonferko E, Flotte T, Bhan AK
Association of basal-lamina defects with epidermal and dermal T6-positive cells: evidence of Langerhans-cell migration. Arch Dermatol Res. 1985; 278(2):126-32.
Association of basal-lamina defects with epidermal and dermal T6-positive cells: evidence of Langerhans-cell migration.
Expression of activation antigens by T cells infiltrating basal cell carcinomas. J Invest Dermatol. 1985 Sep; 85(3):203-6.
Expression of activation antigens by T cells infiltrating basal cell carcinomas.
Capsule dermatopathology: clinicopathologic types of malignant melanoma--relevance to biologic behavior and diagnostic surgical approach. J Dermatol Surg Oncol. 1985 Jul; 11(7):674-82.
Capsule dermatopathology: clinicopathologic types of malignant melanoma--relevance to biologic behavior and diagnostic surgical approach.
van Den Brink MR, Moore E, Horndasch KJ, Crawford JM, Hoffman J, Murphy GF, Burakoff SJ
Fas-deficient lpr mice are more susceptible to graft-versus-host disease. J Immunol. 2000 Jan 01; 164(1):469-80.
Fas-deficient lpr mice are more susceptible to graft-versus-host disease.