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Todd Allen, Ph.D.

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Overview
The Allen Lab builds on its long-standing interest in T cell responses to HIV to explore novel approaches to engineering human immune cells to more effectively target and eliminate the HIV reservoir. We are also utilizing novel gene-editing approaches to block the transmission of HIV and curtail infection.

The Allen Lab focuses on translating recent successes in CRISPR gene editing and CAR T cell immunotherapies towards developing a functional cure for HIV. Our work leverages an innovative human stem cell–engrafted mouse model capable of supporting robust HIV infection and developing human immune responses to HIV. We are also using this model to decipher the host and viral factors influencing the mucosal transmission of HIV.

https://ragoninstitute.org/allen/
https://virologyphd.hms.harvard.edu/people/todd-allen

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19AI149680 (RILEY, JAMES L) May 15, 2020 - Apr 30, 2025
    NIH
    Engineering T cells to Provide Durable Control of HIV-1 Replication
    Role: Co-Investigator
  2. U19HL156247 (CANNON, PAULA M) May 15, 2020 - Apr 30, 2025
    NIH
    Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure
    Role: Co-Investigator
  3. U24DA044801 (ALLEN, TODD M) Aug 15, 2017 - Jul 31, 2023
    NIH
    Next-Generation Sequencing Center for GHOSTing Hepatitis C Virus: Transforming Community Based Molecular Surveillance and Outbreak Investigation
    Role: Principal Investigator
  4. U19HL129903 (SCADDEN, DAVID T) Apr 1, 2015 - Mar 31, 2021
    NIH
    A defend and destroy approach to curing HIV
    Role: Co-Principal Investigator
  5. P01AI104715 (ALLEN, TODD M) Feb 7, 2013 - Jan 31, 2020
    NIH
    Optimizing Human B and T Cell Vaccines Against HIV Using Humanized BLT Mice
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.