Title Professor of Medicine Institution Massachusetts General Hospital Address Ragon Institute of MGH, MIT and Harvard Rm 764 400 Technology Square Cambridge MA 02139
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Overview
The Allen Lab builds on its long-standing interest in T cell responses to HIV to explore novel approaches to engineering human immune cells to more effectively target and eliminate the HIV reservoir. We are also utilizing novel gene-editing approaches to block the transmission of HIV and curtail infection.
The Allen Lab focuses on translating recent successes in CRISPR gene editing and CAR T cell immunotherapies towards developing a functional cure for HIV. Our work leverages an innovative human stem cell–engrafted mouse model capable of supporting robust HIV infection and developing human immune responses to HIV. We are also using this model to decipher the host and viral factors influencing the mucosal transmission of HIV.
https://ragoninstitute.org/allen/
https://virologyphd.hms.harvard.edu/people/todd-allen
Research
The research activities and funding listed below are automatically derived from
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U19AI149680
(RILEY, JAMES L)
May 15, 2020 - Apr 30, 2025
Engineering T cells to Provide Durable Control of HIV-1 Replication
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U19HL156247
(CANNON, PAULA M)
May 15, 2020 - Apr 30, 2025
Novel hematopoietic stem cell engineering and transplantation approaches for HIV cure
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U24DA044801
(ALLEN, TODD M)
Aug 15, 2017 - Jul 31, 2023
Next-Generation Sequencing Center for GHOSTing Hepatitis C Virus: Transforming Community Based Molecular Surveillance and Outbreak Investigation
Role: Principal Investigator
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U19HL129903
(SCADDEN, DAVID T)
Apr 1, 2015 - Mar 31, 2021
A defend and destroy approach to curing HIV
Role: Co-Principal Investigator
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P01AI104715
(ALLEN, TODD M)
Feb 7, 2013 - Jan 31, 2020
Optimizing Human B and T Cell Vaccines Against HIV Using Humanized BLT Mice
Role: Principal Investigator
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R01AI090698
(ALLEN, TODD M)
Jun 1, 2010 - May 31, 2015
Protective Role of Subdominant Responses to HIV Restricted by Common HLA Alleles
Role: Principal Investigator
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U19AI082630
(CHUNG, RAYMOND T ;WHERRY, E. JOHN)
Jun 8, 2009 - May 31, 2024
Impact of Immunotherapy on Viral Immunity in Humans
Role: Co-Principal Investigator
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P01AI074415
(ALLEN, TODD M)
Sep 26, 2008 - Jul 31, 2015
Acute HIV Infection: Implications for vaccine design
Role: Principal Investigator
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R21AI076706
(ALTFELD, MARCUS)
Jan 15, 2008 - Dec 31, 2009
Impact of NK Cell Immune Pressures on HCV Evolution and Viral Fitness
Role: Principal Investigator
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R01AI067926
(ALLEN, TODD M)
Aug 15, 2006 - Jan 31, 2011
CD8 T Cell Selective Pressure and HCV Sequence Evolution
Role: Principal Investigator
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U19AI066345
(LAUER, GEORG MICHAEL)
Aug 17, 2005 - Jul 31, 2016
Immune Control and Evasion during Acute HCV Infection
Role: Co-Principal Investigator
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R21AI067078
(ALLEN, TODD M)
Jul 1, 2005 - Jun 30, 2007
Impact of CD8 Escape Mutations on Capsid Structure/Host
Role: Principal Investigator
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R56AI054178
(ALLEN, TODD M)
Jan 1, 2003 - Aug 31, 2011
Impact of CTL Escape Mutations on HIV-1 Replicative Fitness
Role: Principal Investigator
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R01AI054178
(ALLEN, TODD M)
Jan 1, 2003 - Dec 31, 2008
Acute CTL Escape and Viral Variation in HIV
Role: Principal Investigator
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R01AI051231
(ALLEN, TODD M;HUNTER, ERIC)
Mar 15, 2002 - Mar 31, 2024
Virologic Correlates of Heterosexual Transmission
Role: Co-Principal Investigator
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P51RR000167
(CADWALLADER, MARTIN)
Jun 1, 1976 - Apr 30, 2013
Wisconsin National Primate Research Center Support
Role: Co-Principal Investigator
Bibliographic
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