Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ
An acute functional screen identifies an effective antibody targeting amyloid-ß oligomers based on calcium imaging. Sci Rep. 2018 03 15; 8(1):4634.
An acute functional screen identifies an effective antibody targeting amyloid-ß oligomers based on calcium imaging.
Case Western Reserve University, Neuroscience
Massachusetts General Hospital/Harvard Medical School
Massachusetts General Hospital/Harvard Medical School, Neurology
Kastanenka KV, Arbel-Ornath M, Hudry E, Galea E, Xie H, and Bacskai BJ.
Optical probes for in-vivo imaging. Optical Probes in Biology. Jin Zhang and Carsten Schultz (Eds). Taylor and Francis Group. USA.
Optical probes for in-vivo imaging. Optical Probes in Biology. Jin Zhang and Carsten Schultz (Eds). Taylor and Francis Group. USA. 2015.
Optical probes for in-vivo imaging. Optical Probes in Biology. Jin Zhang and Carsten Schultz (Eds). Taylor and Francis Group. USA
Kastanenka KV, Herlitze S, Boyden ES, Tsai L-H and Bacskai BJ.
Optogenetics shed light on Alzheimer’s disease.
EC Neurology. Optogenetics shed light on Alzheimer’s disease. 2017; (01):27-29.
Wang X, Arbel-Ornath M, Wegmann SK, Kastanenka KV, and Bacskai BJ.
Chapter 3: In vivo imaging in neurodegenerative diseases. Advances in intravital microscopy: from basic to clinical research. R. Weigert (Ed.), Springer. USA
Chapter 3: In vivo imaging in neurodegenerative diseases. Advances in intravital microscopy: from basic to clinical research. R. Weigert (Ed.), Springer. USA. 2014.
György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018 Jun 01; 11:429-440.
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.
Kastanenka KV, Moreno-Bote R, De Pittà M, Perea G, Eraso-Pichot A, Masgrau R, Poskanzer KE, Galea E
A roadmap to integrate astrocytes into Systems Neuroscience. Glia. 2020 01; 68(1):5-26.
A roadmap to integrate astrocytes into Systems Neuroscience.
Veterans Affairs Boston Healthcare System
Vincent and Stella Coates Professor of Neurologic Diseases in the Department of Neurology
John B. Penney, Jr. Professor of Neurology
Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ
Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Sci Rep. 2019 06 20; 9(1):8964.
Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology.
Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Front Neurosci. 2020; 14:705.
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease.
Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A
Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325.
Reactive astrocyte nomenclature, definitions, and future directions.
Lee YF, Lariviere L, Russ AN, Choi SZ, Bacskai BJ, Kastanenka KV
Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model. eNeuro. 2021 May-Jun; 8(3).
Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model.
Thankachan S, Yang C, Kastanenka KV, Bacskai BJ, Gerashchenko D
Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice. Sci Rep. 2022 07 19; 12(1):12278.
Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice.
Thankachan S, Gerashchenko A, Kastanenka KV, Bacskai BJ, Gerashchenko D
Optimization of real-time analysis of sleep-wake cycle in mice. MethodsX. 2022; 9:101811.
Optimization of real-time analysis of sleep-wake cycle in mice.
Algamal M, Russ AN, Miller MR, Hou SS, Maci M, Munting LP, Zhao Q, Gerashchenko D, Bacskai BJ, Kastanenka KV
Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease. Commun Biol. 2022 12 02; 5(1):1323.
Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease.
Lee YF, Russ AN, Zhao Q, Maci M, Miller MR, Hou SS, Algamal M, Zhao Z, Li H, Gelwan N, Gomperts SN, Araque A, Galea E, Bacskai BJ, Kastanenka KV
Optogenetic Targeting of Astrocytes Restores Slow Brain Rhythm Function and Slows Alzheimer's Disease Pathology. Res Sq. 2023 Apr 25.
Optogenetic Targeting of Astrocytes Restores Slow Brain Rhythm Function and Slows Alzheimer's Disease Pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Calcium sensor Yellow Cameleon 3.6 as a tool to support the calcium hypothesis of Alzheimer's disease. Alzheimers Dement. 2023 09; 19(9):4196-4203.
Calcium sensor Yellow Cameleon 3.6 as a tool to support the calcium hypothesis of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America
Building transformers from neurons and astrocytes. Proc Natl Acad Sci U S A. 2023 08 22; 120(34):e2219150120.
Building transformers from neurons and astrocytes.
Lee YF, Russ AN, Zhao Q, Perle SJ, Maci M, Miller MR, Hou SS, Algamal M, Zhao Z, Li H, Gelwan N, Liu Z, Gomperts SN, Araque A, Galea E, Bacskai BJ, Kastanenka KV
Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer's disease pathology. Sci Rep. 2023 08 11; 13(1):13075.
Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer's disease pathology.
Zhao Q, Maci M, Miller MR, Zhou H, Zhang F, Algamal M, Lee YF, Hou SS, Perle SJ, Le H, Russ AN, Lo EH, Gerashchenko D, Gomperts SN, Bacskai BJ, Kastanenka KV
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model. Mol Neurodegener. 2023 12 01; 18(1):93.
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model.
Yu L, Russ AN, Algamal M, Abedin MJ, Zhao Q, Miller MR, Perle SJ, Kastanenka KV
Slow wave activity disruptions and memory impairments in a mouse model of aging. Neurobiol Aging. 2024 08; 140:12-21.
Slow wave activity disruptions and memory impairments in a mouse model of aging.
Miller MR, Lariviere L, Pagnier GJ, Aygar S, Wieckiewicz N, Maesako M, Bacskai BJ, Kastanenka KV
NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-ß-Mediated Damage. J Alzheimers Dis. 2024; 99(2):477-483.
NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-ß-Mediated Damage.
Kashiwagi S, Yokomizo S, Bragin DE, Perle SJ, Kastanenka KV, Gerashchenko D, Atochin DN
Advances in experimental medicine and biology
Therapeutic Potentials of Near-Infrared II Photobiomodulation to Treat Cerebrovascular Diseases via Nitric Oxide Signalling. Adv Exp Med Biol. 2024; 1463:195-200.
Therapeutic Potentials of Near-Infrared II Photobiomodulation to Treat Cerebrovascular Diseases via Nitric Oxide Signalling.
Zhao Q, Yokomizo S, Perle SJ, Lee YF, Zhou H, Miller MR, Li H, Gerashchenko D, Gomperts SN, Bacskai BJ, Kastanenka KV
Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer's disease mouse model. Sci Rep. 2024 10 04; 14(1):23044.
Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer's disease mouse model.
Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17528-33.
Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding.
Zhang F, Zhao Q, Guo S, Hamanaka G, Back DB, Ishikane S, Licastro E, Park JH, Li W, Esposito E, Kastanenka KV, Bacskai BJ, Hayakawa K
Age-associated T cell immunity decreases circulating endothelial progenitor cells. Stem Cells. 2026 Jan 29; 44(2).
Age-associated T cell immunity decreases circulating endothelial progenitor cells.
Yu L, Yokomizo S, Doan TH, Zhao Q, Ganne A, Balasubramaniam M, Kastanenka KV
bioRxiv : the preprint server for biology
Zolpidem restores sleep and slows Alzheimer's progression in a mouse model. bioRxiv. 2025 Sep 09.
Zolpidem restores sleep and slows Alzheimer's progression in a mouse model.
Abedin MJ, Lee YF, Zhang M, Russ AN, Gerashchenko D, Bacskai BJ, Kastanenka KV
Compartment-specific analysis reveals disrupted astrocytic calcium transients in Alzheimer's mice. Res Sq. 2025 Jun 15.
Compartment-specific analysis reveals disrupted astrocytic calcium transients in Alzheimer's mice.
Yu L, Wang X, Doan TH, Fan Y, Bussiere T, Bacskai BJ, Kastanenka KV
Aducanumab binds high molecular weight soluble Aß oligomers and restores intracellular calcium levels. Alzheimers Res Ther. 2025 Aug 04; 17(1):180.
Aducanumab binds high molecular weight soluble Aß oligomers and restores intracellular calcium levels.
Thankachan S, Atochin D, Kastanenka K, Gerashchenko D
Photosensitivity of an aging brain. bioRxiv. 2025 Sep 21.
da Rocha JF, Lance ML, Luo R, Schlachter P, Moreira L, Iqbal MA, Kuhn P, Gardner RS, Valaris S, Islam MR, Gassner GM, Mazuera S, Healy K, Shastri S, Hibbert NB, Moran-Figueroa KV, Haley EB, Pfeiffer RD, Aygar S, Kastanenka KV, Brase L, Harari O, Benitez BA, Tucker NR, Wrann CD
Protective exercise responses in the dentate gyrus of Alzheimer's disease mouse model revealed with single-nucleus RNA-sequencing. Nat Neurosci. 2025 Jul; 28(7):1546-1561.
Protective exercise responses in the dentate gyrus of Alzheimer's disease mouse model revealed with single-nucleus RNA-sequencing.
Yokomizo S, Maci M, Stafford AM, Miller MR, Perle SJ, Takahashi S, Brown-Harding H, Liang L, Lovely A, Algamal M, Gillani RL, Zwang TJ, Richardson D, Naegele JR, Vogt D, Kastanenka KV
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model. bioRxiv. 2025 May 31.
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.
Yokomizo S, Maci M, Stafford AM, Miller MR, Perle SJ, Inagaki S, Takahashi S, Brown-Harding H, Liang L, Lovely A, Algamal M, Gillani RL, Zwang TJ, Richardson D, Naegele JR, Vogt D, Kastanenka KV
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model. Adv Sci (Weinh). 2026 Feb; 13(9):e11472.
Dumurgier J, Schraen S, Gabelle A, Vercruysse O, Bombois S, Laplanche JL, Peoc'h K, Sablonnière B, Kastanenka KV, Delaby C, Pasquier F, Touchon J, Hugon J, Paquet C, Lehmann S
Cerebrospinal fluid amyloid-ß 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015; 7(1):30.
Cerebrospinal fluid amyloid-ß 42/40 ratio in clinical setting of memory centers: a multicentric study.
Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ
The Journal of neuroscience : the official journal of the Society for Neuroscience
Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice. J Neurosci. 2016 12 14; 36(50):12549-12558.
Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.
Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ
Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. PLoS One. 2017; 12(1):e0170275.
Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease.
Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O
Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6.
Pathogenic PS1 phosphorylation at Ser367.
In vivo activation of channelrhodopsin-2 reveals that normal patterns of spontaneous activity are required for motoneuron guidance and maintenance of guidance molecules. J Neurosci. 2010 Aug 04; 30(31):10575-85.
In vivo activation of channelrhodopsin-2 reveals that normal patterns of spontaneous activity are required for motoneuron guidance and maintenance of guidance molecules.
Maeno-Hikichi Y, Polo-Parada L, Kastanenka KV, Landmesser LT
Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctions. J Neurosci. 2011 Jan 19; 31(3):1093-105.
Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctions.
Pagnier GJ, Kastanenka KV, Sohn M, Choi S, Choi SH, Soh H, Bacskai BJ
Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimers Res Ther. 2018 01 29; 10(1):11.
Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models.