Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva PSA, Sartor RB, Besra G, Hauser R, Maxwell A, Llebaria A, Blumberg RS
Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell. 2018 05 17; 173(5):1123-1134.e11.
Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN
Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol. 2006 Nov; 13(11):1193-202.
Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.
Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CN
Journal of immunology (Baltimore, Md. : 1950)
Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008 Mar 01; 180(5):3512-9.
Resolvin E1 metabolome in local inactivation during inflammation-resolution.
Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16; 206(1):15-23.
Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.
Harvard Medical School, Biological Chemistry/Molecular Pharmacology
Biological Chemistry/Molecular Pharmacology
Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest. 2011 Feb; 121(2):569-81.
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.
Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN
Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature. 2012 Apr 25; 484(7395):524-8.
Infection regulates pro-resolving mediators that lower antibiotic requirements.
Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta. 2011 Nov; 1811(11):737-47.
Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators.
Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD
Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol. 2012 Aug 15; 189(4):1983-91.
Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.
Fredman G, Oh SF, Ayilavarapu S, Hasturk H, Serhan CN, Van Dyke TE
Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One. 2011; 6(9):e24422.
Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1.
Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012 Feb 03; 148(3):434-46.
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.
Harvard T.H. Chan School of Public Health
Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
Irene Heinz Given Professor of Immunology and Infectious Diseases
Professor of Computational Biology and Bioinformatics
William Ellery Channing Professor of Medicine
This award supports a 4-year project investigating therapeutic development of lipid A molecules originated from gut symbiotic microbial species.
Gut Symbiotic Lipid A Family: Structures and Immunomodulation in IBD
Erturk-Hasdemir D, Oh SF, Okan NA, Stefanetti G, Gazzaniga FS, Seeberger PH, Plevy SE, Kasper DL
Proceedings of the National Academy of Sciences of the United States of America
Symbionts exploit complex signaling to educate the immune system. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26157-26166.
Symbionts exploit complex signaling to educate the immune system.
Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL
Microbial bile acid metabolites modulate gut ROR?+ regulatory T cell homeostasis. Nature. 2020 01; 577(7790):410-415.
Microbial bile acid metabolites modulate gut ROR?+ regulatory T cell homeostasis.
Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL
Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548.
Microbiota-targeted maternal antibodies protect neonates from enteric infection.
Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, Kim Y, Hwang D, Goh G, Lim KL, Park HM, Lee CH, Oh SF, Petsko GA, Yoon HS, Kim KS
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nat Chem Biol. 2020 08; 16(8):876-886.
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.
Oh SF, Praveena T, Song H, Yoo JS, Jung DJ, Erturk-Hasdemir D, Hwang YS, Lee CC, Le Nours J, Kim H, Lee J, Blumberg RS, Rossjohn J, Park SB, Kasper DL
Host immunomodulatory lipids created by symbionts from dietary amino acids. Nature. 2021 12; 600(7888):302-307.
Host immunomodulatory lipids created by symbionts from dietary amino acids.
Publisher Correction: Host immunomodulatory lipids created by symbionts from dietary amino acids. Nature. 2022 Jan; 601(7894):E32.
Publisher Correction: Host immunomodulatory lipids created by symbionts from dietary amino acids.
This R01 award supports PI’s 5-year project, addressing molecular mechanisms of gut symbiont-derived CD1d ligands.
Gut symbiotic microbiota-derived CD1d ligands and their immunomodulatory mechanisms
Gut Microbiota-Derived Unconventional T Cell Ligands: Contribution to Host Immune Modulation. Immunohorizons. 2022 07 22; 6(7):476-487.
Gut Microbiota-Derived Unconventional T Cell Ligands: Contribution to Host Immune Modulation.
Brüggemann TR, Carlo T, Krishnamoorthy N, Duvall MG, Abdulnour RE, Nijmeh J, Peh HY, Filippakis H, Croze RH, Goh B, Oh SF, Levy BD
Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization. iScience. 2022 Oct 21; 25(10):105185.
Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization.
This R01 award and admin supplement supports PI’s 5-year project, addressing interaction of dietary phytochemicals and probiotic bacterial species and their immunomodulatory impact to the host by production of immunomodulatory sphingolipids.
Contribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipids
Jung DJ, Gebremedhin L, Goh B, Yoo JS, Gazzaniga F, Kasper DL, Oh SF
Kinetic and mechanistic diversity of intestinal immune homeostasis characterized by rapid removal of gut bacteria. Gut Microbes. 2023 Jan-Dec; 15(1):2201154.
Kinetic and mechanistic diversity of intestinal immune homeostasis characterized by rapid removal of gut bacteria.
Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W, Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF, Kasper DL
Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature. 2023 07; 619(7971):837-843.
Gut microbial fatty acid isomerization modulates intraepithelial T cells.
Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota. Exp Mol Med. 2023 09; 55(9):1905-1912.
Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota.
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. 2024 06; 630(8016):437-446.
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Keener JE, Goh B, Yoo JS, Oh SF, Brodbelt JS
Top-Down Characterization of Bacterial Lipopolysaccharides and Lipooligosaccharides Using Activated-Electron Photodetachment Mass Spectrometry. Anal Chem. 2024 06 04; 96(22):9151-9158.
Top-Down Characterization of Bacterial Lipopolysaccharides and Lipooligosaccharides Using Activated-Electron Photodetachment Mass Spectrometry.
An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL
Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell. 2014 Jan 16; 156(1-2):123-33.
Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.
Cho HS, Yoo JS, Song X, Goh B, Diallo A, Lee J, Son S, Hwang YS, Park SB, Oh SF, Kasper DL
Structure of gut microbial glycolipid modulates host inflammatory response. Cell. 2025 Sep 18; 188(19):5295-5312.e18.
Structure of gut microbial glycolipid modulates host inflammatory response.
Heo K, Jung DJ, Yoo JS, Goh B, Kasper DL, Oh SF
bioRxiv : the preprint server for biology
Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host. bioRxiv. 2025 May 02.
Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host.
Yoo JS, Jung DJ, Goh B, Heo K, Zheng W, Lee CC, Seo JI, Geva-Zatorsky N, Wu M, Park SB, Kasper DL, Oh SF
Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions. Nat Microbiol. 2025 Nov; 10(11):2797-2807.
Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions.
Scarpa de Mello S, Schultz B, Goh B, Grote A, Shea T, Muscato J, Oh SF, Manson AL, Earl AM, Walker S, Camargo ILBC, Gilmore MS
Loss of LafB activity reverses daptomycin resistance in E. faecium. mBio. 2026 Jan 14; 17(1):e0071525.
Loss of LafB activity reverses daptomycin resistance in E. faecium.
Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. Science. 2015 Aug 28; 349(6251):993-7.
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6.
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, Serhan CN
Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem. 2006 Aug 11; 281(32):22847-54.
Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions.
Liu W, Cao D, Oh SF, Serhan CN, Kulmacz RJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun; 20(8):1097-108.
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases.
Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol. 2011 Nov; Chapter 14:Unit 14.26.
Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes.
Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN
Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30; 282(13):9323-9334.
Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation.
Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CN
Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 01; 188(9):4527-34.
Resolvin E2 formation and impact in inflammation resolution.