Vice Chair for the Standing Committee on Microbiological Safety
Rasmussen RA, Ong H, Song R, Chenine AL, Ayash-Rashkovsky M, Hu SL, Polacino P, Else JG, Novembre FJ, Ruprecht RM
Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges. AIDS. 2007 Sep 12; 21(14):1841-8.
Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges.
Siddappa NB, Song R, Kramer VG, Chenine AL, Velu V, Ong H, Rasmussen RA, Grisson RD, Wood C, Zhang H, Kankasa C, Amara RR, Else JG, Novembre FJ, Montefiori DC, Ruprecht RM
Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection. J Virol. 2009 Feb; 83(3):1422-32.
Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection.
Janeway CA, Carding S, Jones B, Murray J, Portoles P, Rasmussen R, Rojo J, Saizawa K, West J, Bottomly K
CD4+ T cells: specificity and function. Immunol Rev. 1988 Jan; 101:39-80.
Rasmussen RA, Chin YH, Woodruff JJ, Easton TG
Journal of immunology (Baltimore, Md. : 1950)
Lymphocyte recognition of lymph node high endothelium. VII. Cell surface proteins involved in adhesion defined by monoclonal anti-HEBFLN (A.11) antibody. J Immunol. 1985 Jul; 135(1):19-24.
Lymphocyte recognition of lymph node high endothelium. VII. Cell surface proteins involved in adhesion defined by monoclonal anti-HEBFLN (A.11) antibody.
Gruber A, Chalmers AS, Rasmussen RA, Ong H, Popov S, Andersen J, Hu SL, Ruprecht RM
Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile. Viral Immunol. 2007; 20(1):160-9.
Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile.
Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM
Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine. 2007 Oct 16; 25(42):7470-9.
Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys.
Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Jiang S, Li PL, Baba TW, Montefiori DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Ruprecht RM
Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge. J Med Primatol. 2002 Jun; 31(3):109-19.
Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge.
Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O'Connor D, Ruprecht RM
High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia. AIDS. 2012 Jan 14; 26(2):149-55.
High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia.
Song RJ, Chenine AL, Rasmussen RA, Ruprecht CR, Mirshahidi S, Grisson RD, Xu W, Whitney JB, Goins LM, Ong H, Li PL, Shai-Kobiler E, Wang T, McCann CM, Zhang H, Wood C, Kankasa C, Secor WE, McClure HM, Strobert E, Else JG, Ruprecht RM
Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env. J Virol. 2006 Sep; 80(17):8729-38.
Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env.
Humbert M, Rasmussen RA, Ong H, Kaiser FM, Hu SL, Ruprecht RM
Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing. PLoS One. 2008; 3(12):e3937.
Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing.
Tso FY, Hoffmann FG, Tully DC, Lemey P, Rasmussen RA, Zhang H, Ruprecht RM, Wood C
A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression. AIDS. 2009 Sep 10; 23(14):1817-28.
A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression.
Bachler BC, Humbert M, Palikuqi B, Siddappa NB, Lakhashe SK, Rasmussen RA, Ruprecht RM
Novel biopanning strategy to identify epitopes associated with vaccine protection. J Virol. 2013 Apr; 87(8):4403-16.
Novel biopanning strategy to identify epitopes associated with vaccine protection.
Goldmacher VS, Bourret LA, Levine BA, Rasmussen RA, Pourshadi M, Lambert JM, Anderson KC
Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma. Blood. 1994 Nov 01; 84(9):3017-25.
Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma.
Vivier E, Sorrell JM, Ackerly M, Robertson MJ, Rasmussen RA, Levine H, Anderson P
Developmental regulation of a mucinlike glycoprotein selectively expressed on natural killer cells. J Exp Med. 1993 Dec 01; 178(6):2023-33.
Developmental regulation of a mucinlike glycoprotein selectively expressed on natural killer cells.
Tsai MY, Welge BG, Hanson NQ, Bignell MK, Vessey J, Schwichtenberg K, Yang F, Bullemer FE, Rasmussen R, Graham KJ
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases. Atherosclerosis. 1999 Mar; 143(1):163-70.
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.
Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM
Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? J Med Primatol. 2001 Aug; 30(4):190-6.
Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?
Rasmussen RA, Hofmann-Lehman R, Montefiori DC, Li PL, Liska V, Vlasak J, Baba TW, Schmitz JE, Kuroda MJ, Robinson HL, McClure HM, Lu S, Hu SL, Rizvi TA, Ruprecht RM
DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus. J Med Primatol. 2002 Feb; 31(1):40-60.
DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus.
Bimodal AIDS vaccine approach: induction of cellular as well as humoral immunity can protect from systemic infection. Vaccine. 2010 May 26; 28 Suppl 2:B25-31.
Bimodal AIDS vaccine approach: induction of cellular as well as humoral immunity can protect from systemic infection.
Collinson AR, Lambert JM, Liu Y, O'Dea C, Shah SA, Rasmussen RA, Goldmacher VS
International journal of immunopharmacology
Anti-CD6-blocked ricin: an anti-pan T-cell immunotoxin. Int J Immunopharmacol. 1994 Jan; 16(1):37-49.
Anti-CD6-blocked ricin: an anti-pan T-cell immunotoxin.
In vitro adherence of lymphocytes to unfixed and fixed high endothelial cells of lymph nodes. J Immunol. 1979 Nov; 123(5):2369-72.
In vitro adherence of lymphocytes to unfixed and fixed high endothelial cells of lymph nodes.
Hofmann-Lehmann R, Williams AL, Swenerton RK, Li PL, Rasmussen RA, Chenine AL, McClure HM, Ruprecht RM
Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection. AIDS Res Hum Retroviruses. 2002 Jun 10; 18(9):627-39.
Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection.
Ferrantelli F, Rasmussen RA, Buckley KA, Li PL, Wang T, Montefiori DC, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM
Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies. J Infect Dis. 2004 Jun 15; 189(12):2167-73.
Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies.
Simian Acquired Immunodeficiency Syndrome
Professor of Microbiology and Immunobiology, Emeritus
William Rosenberg Professor of Medicine, Emeritus
Phillip T. and Susan M. Ragon Professor of Medicine
William Bosworth Castle Professor of Medicine
Jerome and Nancy Kohlberg Professor of Medicine, Emeritus
Radiation Oncology Professor at Harvard Medical School, Emeritus
Bachler BC, Humbert M, Lakhashe SK, Rasmussen RA, Ruprecht RM
Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia. Retrovirology. 2013 Jun 21; 10:63.
Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia.
Ruprecht RM, Hu Y, Liska V, Rasmussen R, Sharma P
Correlates of immune protection after vaccination with attenuated live murine leukemia virus. AIDS Res Hum Retroviruses. 1996 Mar 20; 12(5):375-7.
Correlates of immune protection after vaccination with attenuated live murine leukemia virus.
Ruprecht RM, Baba TW, Rasmussen R, Hu Y, Sharma PL
Murine and simian retrovirus models: the threshold hypothesis. AIDS. 1996; 10 Suppl A:S33-40.
Murine and simian retrovirus models: the threshold hypothesis.
Ferrantelli F, Kitabwalla M, Rasmussen RA, Cao C, Chou TC, Katinger H, Stiegler G, Cavacini LA, Bai Y, Cotropia J, Ugen KE, Ruprecht RM
Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine. J Infect Dis. 2004 Jan 01; 189(1):71-4.
Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine.
Rasmussen RA, Sharma PL, Hu Y, Ruprecht RM
Vaccine protection by subinfectious doses of a live murine leukemia virus. Leukemia. 1999 Apr; 13 Suppl 1:S94-5.
Vaccine protection by subinfectious doses of a live murine leukemia virus.
Ayash-Rashkovsky M, Chenine AL, Steele LN, Lee SJ, Song R, Ong H, Rasmussen RA, Hofmann-Lehmann R, Else JG, Augostini P, McClure HM, Secor WE, Ruprecht RM
Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection. Infect Immun. 2007 Apr; 75(4):1751-6.
Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection.
Rasmussen RA, Counts SL, Lambert JM, Collinson AR
Blocked ricin-conjugated T cell immunotoxins: effect of anti-CD6-blocked ricin on normal T cell function. Cancer Immunol Immunother. 1992; 35(5):355-63.
Blocked ricin-conjugated T cell immunotoxins: effect of anti-CD6-blocked ricin on normal T cell function.
Ferrantelli F, Rasmussen RA, Hofmann-Lehmann R, Xu W, McClure HM, Ruprecht RM
Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV. Vaccine. 2002 Dec 19; 20 Suppl 4:A61-5.
Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV.
Rasmussen RA, Montefiori DC, Robinson HL, McClure HM, Ruprecht RM
Heterologous neutralizing antibody induction in a simian-human immunodeficiency virus primate model: lack of original antigenic sin. J Infect Dis. 2001 Dec 15; 184(12):1603-7.
Heterologous neutralizing antibody induction in a simian-human immunodeficiency virus primate model: lack of original antigenic sin.
Chin YH, Rasmussen RA, Woodruff JJ, Easton TG
A monoclonal anti-HEBFPP antibody with specificity for lymphocyte surface molecules mediating adhesion to Peyer's patch high endothelium of the rat. J Immunol. 1986 Apr 01; 136(7):2556-61.
A monoclonal anti-HEBFPP antibody with specificity for lymphocyte surface molecules mediating adhesion to Peyer's patch high endothelium of the rat.
Ruprecht RM, Hofmann-Lehmann R, Smith-Franklin BA, Rasmussen RA, Liska V, Vlasak J, Xu W, Baba TW, Chenine AL, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Montefiori DC, McClure HM
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies. Transfus Clin Biol. 2001 Aug; 8(4):350-8.
Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies.
Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM
Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis. 2010 Apr 15; 201(8):1155-63.
Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.
Rasmussen RA, Counts SL, Daley JF, Schlossman SF
Isolation and characterization of CD6- T cells from peripheral blood. J Immunol. 1994 Jan 15; 152(2):527-36.
Isolation and characterization of CD6- T cells from peripheral blood.
Siddappa NB, Hemashettar G, Wong YL, Lakhashe S, Rasmussen RA, Watkins JD, Novembre FJ, Villinger F, Else JG, Montefiori DC, Ruprecht RM
Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis. J Med Primatol. 2011 Apr; 40(2):120-8.
Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis.
Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 05; 29(34):5611-22.
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.
Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V, Ferrantelli F, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Chou TC, Andersen J, Ruprecht RM
Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge. J Virol. 2001 Aug; 75(16):7470-80.
Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.
Chenine AL, Buckley KA, Li PL, Rasmussen RA, Ong H, Jiang S, Wang T, Augostini P, Secor WE, Ruprecht RM
Schistosoma mansoni infection promotes SHIV clade C replication in rhesus macaques. AIDS. 2005 Nov 04; 19(16):1793-7.
Schistosoma mansoni infection promotes SHIV clade C replication in rhesus macaques.
Wu MX, Daley JF, Rasmussen RA, Schlossman SF
Proceedings of the National Academy of Sciences of the United States of America
Monocytes are required to prime peripheral blood T cells to undergo apoptosis. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1525-9.
Monocytes are required to prime peripheral blood T cells to undergo apoptosis.
Ferrantelli F, Hofmann-Lehmann R, Rasmussen RA, Wang T, Xu W, Li PL, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM
Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques. AIDS. 2003 Feb 14; 17(3):301-9.
Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques.
Lakhashe SK, Wang W, Siddappa NB, Hemashettar G, Polacino P, Hu SL, Villinger F, Else JG, Novembre FJ, Yoon JK, Lee SJ, Montefiori DC, Ruprecht RM, Rasmussen RA
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection. PLoS One. 2011; 6(7):e22010.
Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.
Humbert M, Rasmussen RA, Song R, Ong H, Sharma P, Chenine AL, Kramer VG, Siddappa NB, Xu W, Else JG, Novembre FJ, Strobert E, O'Neil SP, Ruprecht RM
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys. Retrovirology. 2008 Oct 17; 5:94.
SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys.
Woods A, West J, Rasmussen R, Bottomly K
Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate. J Immunol. 1987 Jun 15; 138(12):4293-7.
Granulocyte-macrophage colony stimulating factor produced by cloned L3T4a+, class II-restricted T cells induces HT-2 cells to proliferate.
Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM
R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One. 2010 Jul 21; 5(7):e11689.
R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.
Bristow MR, Minobe W, Rasmussen R, Hershberger RE, Hoffman BB
The Journal of pharmacology and experimental therapeutics
Alpha-1 adrenergic receptors in the nonfailing and failing human heart. J Pharmacol Exp Ther. 1988 Dec; 247(3):1039-45.
Alpha-1 adrenergic receptors in the nonfailing and failing human heart.
Ruprecht RM, Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Xu W
1999: a time to re-evaluate AIDS vaccine strategies. J Hum Virol. 2000 Mar-Apr; 3(2):88-93.
1999: a time to re-evaluate AIDS vaccine strategies.
Rasmussen RA, Ong H, Kittel C, Ruprecht CR, Ferrantelli F, Hu SL, Polacino P, Policano P, McKenna J, Moon J, Travis B, Ruprecht RM
DNA prime/protein boost immunization against HIV clade C: safety and immunogenicity in mice. Vaccine. 2006 Mar 20; 24(13):2324-32.
DNA prime/protein boost immunization against HIV clade C: safety and immunogenicity in mice.
Ferrantelli F, Buckley KA, Rasmussen RA, Chalmers A, Wang T, Li PL, Williams AL, Hofmann-Lehmann R, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM
Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques. Virology. 2007 Feb 05; 358(1):69-78.
Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.
Rasmussen RA, Hofmann-Lehmann R, Li PL, Vlasak J, Schmitz JE, Reimann KA, Kuroda MJ, Letvin NL, Montefiori DC, McClure HM, Ruprecht RM
Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques. AIDS. 2002 Apr 12; 16(6):829-38.
Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques.