Dr. Cai’s current research interests are mainly in the area of biomarker evaluation; model selection and validation; prediction methods; personalized medicine in disease diagnosis, prognosis and treatment; statistical inference with high dimensional data; and survival analysis. In addition to her methdological research, Dr. Cai also collaborates with the I2B2 (Informatics for Integrating Biology and the Bedside) center on developing a scalable informatics framework that will bridge clinical research data and the vast data banks arising from basic science research in order to better understand the genetic bases of complex diseases.
John Rock Professor of Population and Translational Data Sciences
McCoy TH, Yu S, Hart KL, Castro VM, Brown HE, Rosenquist JN, Doyle AE, Vuijk PJ, Cai T, Perlis RH
High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records. Biol Psychiatry. 2018 06 15; 83(12):997-1004.
High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records.
McCoy TH, Castro VM, Hart KL, Pellegrini AM, Yu S, Cai T, Perlis RH
Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records. Biol Psychiatry. 2018 06 15; 83(12):1005-1011.
Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records.
Zhong QY, Gelaye B, Smoller JW, Avillach P, Cai T, Williams MA
Adverse obstetric outcomes during delivery hospitalizations complicated by suicidal behavior among US pregnant women. PLoS One. 2018; 13(2):e0192943.
Adverse obstetric outcomes during delivery hospitalizations complicated by suicidal behavior among US pregnant women.
Optimal stratification in outcome prediction using baseline information. Biometrika. 2016 12; 103(4):817-828.
Optimal stratification in outcome prediction using baseline information.
Cerebral Artery Diameter in Inbred Mice Varies as a Function of Strain. Front Neuroanat. 2018; 12:10.
Cerebral Artery Diameter in Inbred Mice Varies as a Function of Strain.
Can A, Castro VM, Dligach D, Finan S, Yu S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture. Stroke. 2018 05; 49(5):1148-1154.
Lipid-Lowering Agents and High HDL (High-Density Lipoprotein) Are Inversely Associated With Intracranial Aneurysm Rupture.
Ersoy H, Goldhaber SZ, Cai T, Luu T, Rosebrook J, Mulkern R, Rybicki F
Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol. 2007 May; 188(5):1246-54.
Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material.
Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, Perlis RH, Smoller JW
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Transl Psychiatry. 2018 04 18; 8(1):86.
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records.
Pathway aggregation for survival prediction via multiple kernel learning. Stat Med. 2018 07 20; 37(16):2501-2515.
Pathway aggregation for survival prediction via multiple kernel learning.
Liao KP, Cai T, Gainer V, Goryachev S, Zeng-treitler Q, Raychaudhuri S, Szolovits P, Churchill S, Murphy S, Kohane I, Karlson EW, Plenge RM
Electronic medical records for discovery research in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Aug; 62(8):1120-7.
Electronic medical records for discovery research in rheumatoid arthritis.
Analysis of randomized comparative clinical trial data for personalized treatment selections. Biostatistics. 2011 Apr; 12(2):270-82.
Analysis of randomized comparative clinical trial data for personalized treatment selections.
Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum. 2013 Mar; 65(3):571-81.
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls.
Can A, Rudy RF, Castro VM, Dligach D, Finan S, Yu S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms. Stroke. 2018 07; 49(7):1747-1750.
Low Serum Calcium and Magnesium Levels and Rupture of Intracranial Aneurysms.
Zhang J, Can A, Mukundan S, Steigner M, Castro VM, Dligach D, Finan S, Yu S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Wang Z, Weiss ST, Du R
Morphological Variables Associated With Ruptured Middle Cerebral Artery Aneurysms. Neurosurgery. 2019 07 01; 85(1):75-83.
Morphological Variables Associated With Ruptured Middle Cerebral Artery Aneurysms.
Zhong QY, Karlson EW, Gelaye B, Finan S, Avillach P, Smoller JW, Cai T, Williams MA
BMC medical informatics and decision making
Screening pregnant women for suicidal behavior in electronic medical records: diagnostic codes vs. clinical notes processed by natural language processing. BMC Med Inform Decis Mak. 2018 05 29; 18(1):30.
Screening pregnant women for suicidal behavior in electronic medical records: diagnostic codes vs. clinical notes processed by natural language processing.
Journal of the American Statistical Association
Multiple Testing of Submatrices of a Precision Matrix with Applications to Identification of Between Pathway Interactions. J Am Stat Assoc. 2018; 113(521):328-339.
Multiple Testing of Submatrices of a Precision Matrix with Applications to Identification of Between Pathway Interactions.
Lu MT, Cai T, Ersoy H, Whitmore AG, Quiroz R, Goldhaber SZ, Rybicki FJ
Interval increase in right-left ventricular diameter ratios at CT as a predictor of 30-day mortality after acute pulmonary embolism: initial experience. Radiology. 2008 Jan; 246(1):281-7.
Interval increase in right-left ventricular diameter ratios at CT as a predictor of 30-day mortality after acute pulmonary embolism: initial experience.
Evaluating longitudinal markers under two-phase study designs. Biostatistics. 2019 07 01; 20(3):485-498.
Evaluating longitudinal markers under two-phase study designs.
Lu MT, Cai T, Ersoy H, Whitmore AG, Levit NA, Goldhaber SZ, Rybicki FJ
The international journal of cardiovascular imaging
Comparison of ECG-gated versus non-gated CT ventricular measurements in thirty patients with acute pulmonary embolism. Int J Cardiovasc Imaging. 2009 Jan; 25(1):101-7.
Comparison of ECG-gated versus non-gated CT ventricular measurements in thirty patients with acute pulmonary embolism.
Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin X
Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet. 2011 Jul 15; 89(1):82-93.
Rare-variant association testing for sequencing data with the sequence kernel association test.
Cai T, Zhang Y, Ho YL, Link N, Sun J, Huang J, Cai TA, Damrauer S, Ahuja Y, Honerlaw J, Huang J, Costa L, Schubert P, Hong C, Gagnon D, Sun YV, Gaziano JM, Wilson P, Cho K, Tsao P, O'Donnell CJ, Liao KP
Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study. JAMA Cardiol. 2018 09 01; 3(9):849-857.
Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study.
Steigner ML, Otero HJ, Cai T, Mitsouras D, Nallamshetty L, Whitmore AG, Ersoy H, Levit NA, Di Carli MF, Rybicki FJ
Narrowing the phase window width in prospectively ECG-gated single heart beat 320-detector row coronary CT angiography. Int J Cardiovasc Imaging. 2009 Jan; 25(1):85-90.
Narrowing the phase window width in prospectively ECG-gated single heart beat 320-detector row coronary CT angiography.
Can A, Rudy RF, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study. Neurology. 2018 09 18; 91(12):e1175-e1181.
Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study.
Hunsaker AR, Oliva IB, Cai T, Trotman-Dickenson B, Gill RR, Hatabu H, Rybicki FJ
Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation. AJR Am J Roentgenol. 2010 Aug; 195(2):W118-24.
Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation.
Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics. 2011 Sep; 67(3):975-86.
Kernel machine approach to testing the significance of multiple genetic markers for risk prediction.
Wu C, Sodickson A, Cai T, Levit NA, Steigner ML, Rybicki FJ, Ledbetter SM
Comparison of respiratory motion artifact from craniocaudal versus caudocranial scanning with 64-MDCT pulmonary angiography. AJR Am J Roentgenol. 2010 Jul; 195(1):155-9.
Comparison of respiratory motion artifact from craniocaudal versus caudocranial scanning with 64-MDCT pulmonary angiography.
Uno H, Cai T, Pencina MJ, D'Agostino RB, Wei LJ
On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med. 2011 May 10; 30(10):1105-17.
On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data.
Semi-supervised validation of multiple surrogate outcomes with application to electronic medical records phenotyping. Biometrics. 2019 03; 75(1):78-89.
Semi-supervised validation of multiple surrogate outcomes with application to electronic medical records phenotyping.
Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics. 2006 Mar; 62(1):279-87.
Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers.
Regularized estimation for the accelerated failure time model. Biometrics. 2009 Jun; 65(2):394-404.
Regularized estimation for the accelerated failure time model.
Elevated International Normalized Ratio Is Associated With Ruptured Aneurysms. Stroke. 2018 09; 49(9):2046-2052.
Elevated International Normalized Ratio Is Associated With Ruptured Aneurysms.
Gronsbell J, Minnier J, Yu S, Liao K, Cai T
Automated feature selection of predictors in electronic medical records data. Biometrics. 2019 03; 75(1):268-277.
Automated feature selection of predictors in electronic medical records data.
Variance components genetic association test for zero-inflated count outcomes. Genet Epidemiol. 2019 02; 43(1):82-101.
Variance components genetic association test for zero-inflated count outcomes.
Validation of psoriatic arthritis diagnoses in electronic medical records using natural language processing. Semin Arthritis Rheum. 2011 Apr; 40(5):413-20.
Validation of psoriatic arthritis diagnoses in electronic medical records using natural language processing.
Imran TF, Posner D, Honerlaw J, Vassy JL, Song RJ, Ho YL, Kittner SJ, Liao KP, Cai T, O'Donnell CJ, Djousse L, Gagnon DR, Gaziano JM, Wilson PW, Cho K
A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program. Clin Epidemiol. 2018; 10:1509-1521.
A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program.
The highest confidence density region and its usage for joint inferences about constrained parameters. Biometrics. 2011 Jun; 67(2):604-10.
The highest confidence density region and its usage for joint inferences about constrained parameters.
Furtado JD, Yamamoto R, Melchior JT, Andraski AB, Gamez-Guerrero M, Mulcahy P, He Z, Cai T, Davidson WS, Sacks FM
Arteriosclerosis, thrombosis, and vascular biology
Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies. Arterioscler Thromb Vasc Biol. 2018 12; 38(12):2827-2842.
Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.
Zhong QY, Mittal LP, Nathan MD, Brown KM, Knudson González D, Cai T, Finan S, Gelaye B, Avillach P, Smoller JW, Karlson EW, Cai T, Williams MA
Use of natural language processing in electronic medical records to identify pregnant women with suicidal behavior: towards a solution to the complex classification problem. Eur J Epidemiol. 2019 Feb; 34(2):153-162.
Use of natural language processing in electronic medical records to identify pregnant women with suicidal behavior: towards a solution to the complex classification problem.
Nonparametric Maximum Likelihood Estimators of Time-Dependent Accuracy Measures for Survival Outcome Under Two-Stage Sampling Designs. J Am Stat Assoc. 2018; 113(522):882-892.
Nonparametric Maximum Likelihood Estimators of Time-Dependent Accuracy Measures for Survival Outcome Under Two-Stage Sampling Designs.
Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T
Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes. Sci Data. 2019 01 08; 6:180298.
Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes.
Tian L, Cai T, Pfeffer MA, Piankov N, Cremieux PY, Wei LJ
Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics. 2009 Apr; 10(2):275-81.
Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction.
Gao X, Lai CQ, Scott T, Shen J, Cai T, Ordovas JM, Tucker KL
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. Am J Epidemiol. 2010 Aug 01; 172(3):271-8.
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults.
Jorge A, Castro VM, Barnado A, Gainer V, Hong C, Cai T, Cai T, Carroll R, Denny JC, Crofford L, Costenbader KH, Liao KP, Karlson EW, Feldman CH
Identifying lupus patients in electronic health records: Development and validation of machine learning algorithms and application of rule-based algorithms. Semin Arthritis Rheum. 2019 08; 49(1):84-90.
Identifying lupus patients in electronic health records: Development and validation of machine learning algorithms and application of rule-based algorithms.
Lu MT, Demehri S, Cai T, Parast L, Hunsaker AR, Goldhaber SZ, Rybicki FJ
Axial and reformatted four-chamber right ventricle-to-left ventricle diameter ratios on pulmonary CT angiography as predictors of death after acute pulmonary embolism. AJR Am J Roentgenol. 2012 Jun; 198(6):1353-60.
Axial and reformatted four-chamber right ventricle-to-left ventricle diameter ratios on pulmonary CT angiography as predictors of death after acute pulmonary embolism.
Evaluating the predictive value of biomarkers with stratified case-cohort design. Biometrics. 2012 Dec; 68(4):1219-27.
Evaluating the predictive value of biomarkers with stratified case-cohort design.
Ning W, Chan S, Beam A, Yu M, Geva A, Liao K, Mullen M, Mandl KD, Kohane I, Cai T, Yu S
Feature extraction for phenotyping from semantic and knowledge resources. J Biomed Inform. 2019 03; 91:103122.
Feature extraction for phenotyping from semantic and knowledge resources.
Zhong QY, Gelaye B, Karlson EW, Avillach P, Smoller JW, Cai T, Williams MA
Associations of antepartum suicidal behaviour with adverse infant and obstetric outcomes. Paediatr Perinat Epidemiol. 2019 03; 33(2):137-144.
Associations of antepartum suicidal behaviour with adverse infant and obstetric outcomes.
Assessing the value of a censored surrogate outcome. Lifetime Data Anal. 2020 04; 26(2):245-265.
Assessing the value of a censored surrogate outcome.
Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R
Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms. Sci Rep. 2019 04 15; 9(1):6054.
Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms.
Chan SF, Hejblum BP, Chakrabortty A, Cai T
Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data. Stat Methods Med Res. 2020 02; 29(2):455-465.
Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data.
Using a surrogate marker for early testing of a treatment effect. Biometrics. 2019 12; 75(4):1253-1263.
Using a surrogate marker for early testing of a treatment effect.
Harvard T.H. Chan School of Public Health
Marion V. Nelson Professor of Biomedical Informatics
John L. Loeb and Frances Lehman Loeb Professor of Epidemiology
Professor of Statistical Computing, Emeritus
Harvey V. Fineberg Professor of Public Health, Emerita
Semi-supervised Algorithms for Risk Assessment with Noisy EHR Data
Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Savova G, Shaw SY, Churchill S, Burke KE, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Use of Narrative Concepts in Electronic Health Records to Validate Associations Between Genetic Factors and Response to Treatment of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 07; 18(8):1890-1892.
Use of Narrative Concepts in Electronic Health Records to Validate Associations Between Genetic Factors and Response to Treatment of Inflammatory Bowel Diseases.
Zhao SS, Hong C, Cai T, Xu C, Huang J, Ermann J, Goodson NJ, Solomon DH, Cai T, Liao KP
Incorporating natural language processing to improve classification of axial spondyloarthritis using electronic health records. Rheumatology (Oxford). 2020 05 01; 59(5):1059-1065.
Incorporating natural language processing to improve classification of axial spondyloarthritis using electronic health records.
Integrative genomic testing of cancer survival using semiparametric linear transformation models. Stat Med. 2016 07 20; 35(16):2831-44.
Integrative genomic testing of cancer survival using semiparametric linear transformation models.
Wang Y, Hong C, Palmer N, Di Q, Schwartz J, Kohane I, Cai T
A fast divide-and-conquer sparse Cox regression. Biostatistics. 2021 04 10; 22(2):381-401.
A fast divide-and-conquer sparse Cox regression.
Liao KP, Sun J, Cai TA, Link N, Hong C, Huang J, Huffman JE, Gronsbell J, Zhang Y, Ho YL, Castro V, Gainer V, Murphy SN, O'Donnell CJ, Gaziano JM, Cho K, Szolovits P, Kohane IS, Yu S, Cai T
Journal of the American Medical Informatics Association : JAMIA
High-throughput multimodal automated phenotyping (MAP) with application to PheWAS. J Am Med Inform Assoc. 2019 11 01; 26(11):1255-1262.
High-throughput multimodal automated phenotyping (MAP) with application to PheWAS.
Liao KP, Diogo D, Cui J, Cai T, Okada Y, Gainer VS, Murphy SN, Gupta N, Mirel D, Ananthakrishnan AN, Szolovits P, Shaw SY, Raychaudhuri S, Churchill S, Kohane I, Karlson EW, Plenge RM
Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls. Ann Rheum Dis. 2014 Jun; 73(6):1170-5.
Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls.
Zhang L, Zhang Y, Cai T, Ahuja Y, He Z, Ho YL, Beam A, Cho K, Carroll R, Denny J, Kohane I, Liao K, Cai T
Automated grouping of medical codes via multiview banded spectral clustering. J Biomed Inform. 2019 12; 100:103322.
Automated grouping of medical codes via multiview banded spectral clustering.
Wang Y, Zhu J, Aroner S, Overvad K, Cai T, Yang M, Tjønneland A, Handberg A, Jensen MK
Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women. Diabetes Metab J. 2020 02; 44(1):134-142.
Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women.
Zhang Y, Cai T, Yu S, Cho K, Hong C, Sun J, Huang J, Ho YL, Ananthakrishnan AN, Xia Z, Shaw SY, Gainer V, Castro V, Link N, Honerlaw J, Huang S, Gagnon D, Karlson EW, Plenge RM, Szolovits P, Savova G, Churchill S, O'Donnell C, Murphy SN, Gaziano JM, Kohane I, Cai T, Liao KP
High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP). Nat Protoc. 2019 12; 14(12):3426-3444.
High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP).
Cai T, Zhang L, Yang N, Kumamaru KK, Rybicki FJ, Cai T, Liao KP
EXTraction of EMR numerical data: an efficient and generalizable tool to EXTEND clinical research. BMC Med Inform Decis Mak. 2019 11 15; 19(1):226.
EXTraction of EMR numerical data: an efficient and generalizable tool to EXTEND clinical research.
Cheng D, Chakrabortty A, Ananthakrishnan AN, Cai T
Estimating average treatment effects with a double-index propensity score. Biometrics. 2020 09; 76(3):767-777.
Estimating average treatment effects with a double-index propensity score.
Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data. Pac Symp Biocomput. 2020; 25:295-306.
Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data.
Two-Sample Tests for High-Dimensional Linear Regression with an Application to Detecting Interactions. Stat Sin. 2018 Jan; 28:63-92.
Two-Sample Tests for High-Dimensional Linear Regression with an Application to Detecting Interactions.
Large-Scale Simultaneous Testing of Cross-Covariance Matrices with Applications to PheWAS. Stat Sin. 2019 Apr; 29(2):983-1005.
Large-Scale Simultaneous Testing of Cross-Covariance Matrices with Applications to PheWAS.
Koch M, DeKosky ST, Goodman M, Sun J, Furtado JD, Fitzpatrick AL, Mackey RH, Cai T, Lopez OL, Kuller LH, Mukamal KJ, Jensen MK
High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia. J Lipid Res. 2020 03; 61(3):445-454.
High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia.
Tedeschi SK, Cai T, He Z, Ahuja Y, Hong C, Yates KA, Dahal K, Xu C, Lyu H, Yoshida K, Solomon DH, Cai T, Liao KP
Classifying Pseudogout Using Machine Learning Approaches With Electronic Health Record Data. Arthritis Care Res (Hoboken). 2021 03; 73(3):442-448.
Classifying Pseudogout Using Machine Learning Approaches With Electronic Health Record Data.
Sonabend W A, Pellegrini AM, Chan S, Brown HE, Rosenquist JN, Vuijk PJ, Doyle AE, Perlis RH, Cai T
Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec. PLoS One. 2020; 15(4):e0230663.
Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec.
FUNCTIONAL PRINCIPAL VARIANCE COMPONENT TESTING FOR A GENETIC ASSOCIATION STUDY OF HIV PROGRESSION. Ann Appl Stat. 2018 Sep; 12(3):1871-1893.
FUNCTIONAL PRINCIPAL VARIANCE COMPONENT TESTING FOR A GENETIC ASSOCIATION STUDY OF HIV PROGRESSION.
Cheng D, Cushing KC, Cai T, Ananthakrishnan AN
Safety and Efficacy of Tumor Necrosis Factor Antagonists in Older Patients With Ulcerative Colitis: Patient-Level Pooled Analysis of Data From Randomized Trials. Clin Gastroenterol Hepatol. 2021 May; 19(5):939-946.e4.
Safety and Efficacy of Tumor Necrosis Factor Antagonists in Older Patients With Ulcerative Colitis: Patient-Level Pooled Analysis of Data From Randomized Trials.
Robust and efficient semi-supervised estimation of average treatment effects with application to electronic health records data. Biometrics. 2021 06; 77(2):413-423.
Robust and efficient semi-supervised estimation of average treatment effects with application to electronic health records data.
Huang S, Huang J, Cai T, Dahal KP, Cagan A, He Z, Stratton J, Gorelik I, Hong C, Cai T, Liao KP
Impact of ICD10 and secular changes on electronic medical record rheumatoid arthritis algorithms. Rheumatology (Oxford). 2020 12 01; 59(12):3759-3766.
Impact of ICD10 and secular changes on electronic medical record rheumatoid arthritis algorithms.
Chan S, Wang X, Jazic I, Peskoe S, Zheng Y, Cai T
Developing and evaluating risk prediction models with panel current status data. Biometrics. 2021 06; 77(2):599-609.
Developing and evaluating risk prediction models with panel current status data.
Ahuja Y, Zhou D, He Z, Sun J, Castro VM, Gainer V, Murphy SN, Hong C, Cai T
sureLDA: A multidisease automated phenotyping method for the electronic health record. J Am Med Inform Assoc. 2020 08 01; 27(8):1235-1243.
sureLDA: A multidisease automated phenotyping method for the electronic health record.
Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker. Biometrika. 2020 Mar; 107(1):107-122.
Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker.
Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia. JAMA Netw Open. 2020 07 01; 3(7):e209250.
Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia.
Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Yu S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R
Age and morphology of posterior communicating artery aneurysms. Sci Rep. 2020 07 14; 10(1):11545.
Age and morphology of posterior communicating artery aneurysms.
Zhang T, Goodman M, Zhu F, Healy B, Carruthers R, Chitnis T, Weiner H, Cai T, De Jager P, Tremlett H, Xia Z
Neurology(R) neuroimmunology & neuroinflammation
Phenome-wide examination of comorbidity burden and multiple sclerosis disease severity. Neurol Neuroimmunol Neuroinflamm. 2020 11; 7(6).
Phenome-wide examination of comorbidity burden and multiple sclerosis disease severity.
Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, Cimino J, Waitman LR, Omenn GS, Malovini A, Moore JH, Beaulieu-Jones BK, Tibollo V, Murphy SN, Yi SL, Keller MS, Bellazzi R, Hanauer DA, Serret-Larmande A, Gutierrez-Sacristan A, Holmes JJ, Bell DS, Mandl KD, Follett RW, Klann JG, Murad DA, Scudeller L, Bucalo M, Kirchoff K, Craig J, Obeid J, Jouhet V, Griffier R, Cossin S, Moal B, Patel LP, Bellasi A, Prokosch HU, Kraska D, Sliz P, Tan ALM, Ngiam KY, Zambelli A, Mowery DL, Schiver E, Devkota B, Bradford RL, Daniar M, Daniel C, Benoit V, Bey R, Paris N, Serre P, Orlova N, Dubiel J, Hilka M, Jannot AS, Breant S, Leblanc J, Griffon N, Burgun A, Bernaux M, Sandrin A, Salamanca E, Cormont S, Ganslandt T, Gradinger T, Champ J, Boeker M, Martel P, Esteve L, Gramfort A, Grisel O, Leprovost D, Moreau T, Varoquaux G, Vie JJ, Wassermann D, Mensch A, Caucheteux C, Haverkamp C, Lemaitre G, Bosari S, Krantz ID, South A, Cai T, Kohane IS
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020; 3:109.
International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium.
Evaluating multiple surrogate markers with censored data. Biometrics. 2021 12; 77(4):1315-1327.
Evaluating multiple surrogate markers with censored data.
Sacks FM, Liang L, Furtado JD, Cai T, Davidson WS, He Z, McClelland RL, Rimm EB, Jensen MK
Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2714-2727.
Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies.
A divide-and-conquer method for sparse risk prediction and evaluation. Biostatistics. 2022 04 13; 23(2):397-411.
A divide-and-conquer method for sparse risk prediction and evaluation.
Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R
Surrounding vascular geometry associated with basilar tip aneurysm formation. Sci Rep. 2020 10 21; 10(1):17928.
Surrounding vascular geometry associated with basilar tip aneurysm formation.
Vascular Geometry Associated with Anterior Communicating Artery Aneurysm Formation. World Neurosurg. 2021 02; 146:e1318-e1325.
Vascular Geometry Associated with Anterior Communicating Artery Aneurysm Formation.
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Identifying surrogate markers in real-world comparative effectiveness research. Stat Med. 2022 11 20; 41(26):5290-5304.
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Efficient Evaluation of Prediction Rules in Semi-Supervised Settings under Stratified Sampling. J R Stat Soc Series B Stat Methodol. 2022 Sep; 84(4):1353-1391.
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Hospitalizations Associated With Mental Health Conditions Among Adolescents in the US and France During the COVID-19 Pandemic. JAMA Netw Open. 2022 12 01; 5(12):e2246548.
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Informative missingness: What can we learn from patterns in missing laboratory data in the electronic health record? J Biomed Inform. 2023 03; 139:104306.
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Using a surrogate with heterogeneous utility to test for a treatment effect. Stat Med. 2023 01 15; 42(1):68-88.
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Utilizing biologic disease-modifying anti-rheumatic treatment sequences to subphenotype rheumatoid arthritis. Arthritis Res Ther. 2023 06 02; 25(1):93.
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