Bertarelli Professor of Translational Medical Science, Emeritus
Koibuchi N, Liu Y, Fukuda H, Takeshita A, Yen PM, Chin WW
ROR alpha augments thyroid hormone receptor-mediated transcriptional activation. Endocrinology. 1999 Mar; 140(3):1356-64.
ROR alpha augments thyroid hormone receptor-mediated transcriptional activation.
Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999 Mar; 237(3):231-40.
Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors.
Kaiser UB, Lee BL, Carroll RS, Unabia G, Chin WW, Childs GV
Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology. 1992 May; 130(5):3048-56.
Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats.
Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB
Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97.
Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene.
Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, Chin WW, Braverman LE
Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999 Aug; 140(8):3404-10.
Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein.
Hsu DW, el-Azouzi M, Black PM, Chin WW, Hedley-Whyte ET, Kaplan LM
Estrogen increases galanin immunoreactivity in hyperplastic prolactin-secreting cells in Fisher 344 rats. Endocrinology. 1990 Jun; 126(6):3159-67.
Estrogen increases galanin immunoreactivity in hyperplastic prolactin-secreting cells in Fisher 344 rats.
Ridgway EC, Klibanski A, Martorana MA, Milbury P, Kieffer JD, Chin WW
The effect of somatostatin on the release of thyrotropin and its subunits from bovine anterior pituitary cells in vitro. Endocrinology. 1983 Jun; 112(6):1937-42.
The effect of somatostatin on the release of thyrotropin and its subunits from bovine anterior pituitary cells in vitro.
Chin WW, Kronenberg HM, Dee PC, Maloof F, Habener JF
Proceedings of the National Academy of Sciences of the United States of America
Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin. Proc Natl Acad Sci U S A. 1981 Sep; 78(9):5329-33.
Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
Perylenequinones in photodynamic therapy: cellular versus vascular response. J Environ Pathol Toxicol Oncol. 2006; 25(1-2):223-37.
Perylenequinones in photodynamic therapy: cellular versus vascular response.
Chin WW, Godine JE, Klein DR, Chang AS, Tan LK, Habener JF
Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4649-53.
Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin.
Ross DS, Downing MF, Chin WW, Ridgway EC
Discordant changes in pituitary concentrations of LH and TSH subunits following hormonal manipulation. Metabolism. 1984 Mar; 33(3):230-4.
Discordant changes in pituitary concentrations of LH and TSH subunits following hormonal manipulation.
Cell-free synthesis and processing of the precursors to the subunits of luteinizing hormone. J Biol Chem. 1981 Mar 10; 256(5):2475-9.
Cell-free synthesis and processing of the precursors to the subunits of luteinizing hormone.
Regulation of angiotensinogen gene expression by estrogen. J Hypertens. 1992 Apr; 10(4):361-6.
Regulation of angiotensinogen gene expression by estrogen.
Kubin MZ, Parshley DL, Din W, Waugh JY, Davis-Smith T, Smith CA, Macduff BM, Armitage RJ, Chin W, Cassiano L, Borges L, Petersen M, Trinchieri G, Goodwin RG
Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. Eur J Immunol. 1999 11; 29(11):3466-77.
Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48.
Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD
Thyroid : official journal of the American Thyroid Association
Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone: consensus statement from the first workshop on thyroid hormone resistance, July 10-11th 1993, Cambridge, U.K. Thyroid. 1994; 4(1):135-7.
Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone: consensus statement from the first workshop on thyroid hormone resistance, July 10-11th 1993, Cambridge, U.K.
Evidence that phosphorylation events participate in thyroid hormone action. Endocrinology. 1994 Feb; 134(2):543-8.
Evidence that phosphorylation events participate in thyroid hormone action.
Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs. J Biol Chem. 1996 May 31; 271(22):12903-8.
Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs.
Gharib SD, Leung PC, Carroll RS, Chin WW
Molecular endocrinology (Baltimore, Md.)
Androgens positively regulate follicle-stimulating hormone beta-subunit mRNA levels in rat pituitary cells. Mol Endocrinol. 1990 Nov; 4(11):1620-6.
Androgens positively regulate follicle-stimulating hormone beta-subunit mRNA levels in rat pituitary cells.
Bhuvaneswari R, Gan YY, Lucky SS, Chin WW, Ali SM, Soo KC, Olivo M
Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. Mol Cancer. 2008 Jun 13; 7:56.
Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy.
Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER
Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J Biol Chem. 1988 Sep 15; 263(26):13317-23.
Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin.
The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor. Curr Surg. 1989 Jul-Aug; 46(4):298-301.
The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor.
Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7771-4.
Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.
A call for sharing: adapting pharmaceutical research to new realities. Sci Transl Med. 2009 Dec 02; 1(9):9cm8.
A call for sharing: adapting pharmaceutical research to new realities.
Chin WW, Habener JF, Kieffer JD, Maloof F
Cell-free translation of the messenger RNA coding for the alpha subunit of thyroid-stimulating hormone. J Biol Chem. 1978 Nov 25; 253(22):7985-8.
Cell-free translation of the messenger RNA coding for the alpha subunit of thyroid-stimulating hormone.
Van Meter Award. Thyroid. 1995 Feb; 5(1):79.
The Journal of clinical endocrinology and metabolism
Genes and endocrine maladies. J Clin Endocrinol Metab. 1990 Oct; 71(4):790-1.
Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones. Gene. 1988 Oct 15; 70(1):67-74.
Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones.
Chin WW, Shupnik MA, Ross DS, Habener JF, Ridgway EC
Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones. Endocrinology. 1985 Mar; 116(3):873-8.
Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones.
Sunday ME, Kaplan LM, Motoyama E, Chin WW, Spindel ER
Laboratory investigation; a journal of technical methods and pathology
Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. Lab Invest. 1988 Jul; 59(1):5-24.
Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease.
Protein bound carboxyl-methyl ester as a precursor of methanol formation during oxidation of dimethylnitrosamine in vitro. Cancer Lett. 1977 Mar; 2(4-5):279-84.
Protein bound carboxyl-methyl ester as a precursor of methanol formation during oxidation of dimethylnitrosamine in vitro.
Naylor SL, Sakaguchi AY, Spindel E, Chin WW
Human gastrin-releasing peptide gene is located on chromosome 18. Somat Cell Mol Genet. 1987 Jan; 13(1):87-91.
Human gastrin-releasing peptide gene is located on chromosome 18.
Current perspectives on the role of thyroid hormone in growth and development of cerebellum. Cerebellum. 2003; 2(4):279-89.
Current perspectives on the role of thyroid hormone in growth and development of cerebellum.
Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39.
Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA.
Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. DNA Cell Biol. 1990 Mar; 9(2):77-83.
Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.
Showers MO, Darling DS, Kieffer GD, Chin WW
Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor. DNA Cell Biol. 1991 Apr; 10(3):211-21.
Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor.
Molecular biology of thyrotropin. Endocr Rev. 1989 Nov; 10(4):459-75.
Papavasiliou SS, Zmeili S, Khoury S, Landefeld TD, Chin WW, Marshall JC
Gonadotropin-releasing hormone differentially regulates expression of the genes for luteinizing hormone alpha and beta subunits in male rats. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):4026-9.
Gonadotropin-releasing hormone differentially regulates expression of the genes for luteinizing hormone alpha and beta subunits in male rats.
Gharib SD, Wierman ME, Badger TM, Chin WW
Sex steroid hormone regulation of follicle-stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat. J Clin Invest. 1987 Aug; 80(2):294-9.
Sex steroid hormone regulation of follicle-stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat.
alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. J Biol Chem. 1982 Jul 25; 257(14):8368-71.
alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs.
Mine M, Tramontano D, Chin WW, Ingbar SH
Interleukin-1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture. Endocrinology. 1987 Mar; 120(3):1212-4.
Interleukin-1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture.
Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments. Mol Endocrinol. 1989 Mar; 3(3):474-80.
Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments.
Na S, Ma Y, Zhao J, Schmidt C, Zeng QQ, Chandrasekhar S, Chin WW, Nagpal S
A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Dis. 2011 Jan 26; 2011:132958.
A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia.
Shupnik MA, Weinmann CM, Notides AC, Chin WW
An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness. J Biol Chem. 1989 Jan 05; 264(1):80-6.
An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness.
Luteinizing and follicle-stimulating hormones. Cell-free translations of messenger RNAs coding for subunit precursors. J Biol Chem. 1980 Sep 25; 255(18):8780-3.
Luteinizing and follicle-stimulating hormones. Cell-free translations of messenger RNAs coding for subunit precursors.
Chin WW, Maloof F, Martorana MA, Pierce JG, Ridgway EC
Production and release of thyrotropin and its subunits by monolayer cultures containing bovine anterior pituitary cells. Endocrinology. 1981 Feb; 108(2):387-94.
Production and release of thyrotropin and its subunits by monolayer cultures containing bovine anterior pituitary cells.
Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW
Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology. 1995 Apr; 136(4):1766-74.
Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland.
Yen PM, Brubaker JH, Apriletti JW, Baxter JD, Chin WW
Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation. Endocrinology. 1994 Mar; 134(3):1075-81.
Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation.
Kaiser UB, Jakubowiak A, Steinberger A, Chin WW
Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro. Endocrinology. 1993 Aug; 133(2):931-4.
Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro.
Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. J Biol Chem. 1996 May 03; 271(18):10910-6.
Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity.
Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts. BMC Pharmacol. 2007 Dec 01; 7:15.
Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts.
Thyroid-stimulating hormone biosynthesis. Cellular processing, assembly, and release of subunits. J Biol Chem. 1981 Mar 25; 256(6):3059-66.
Thyroid-stimulating hormone biosynthesis. Cellular processing, assembly, and release of subunits.
Yen PM, Wilcox EC, Hayashi Y, Refetoff S, Chin WW
Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants. Endocrinology. 1995 Jul; 136(7):2845-51.
Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors. Endocrinology. 1995 Feb; 136(2):440-5.
Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors.
9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. Endocrinology. 1994 Nov; 135(5):1956-62.
9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors.
Spratt DI, Chin WW, Ridgway EC, Crowley WF
Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free alpha-subunit secretion. J Clin Endocrinol Metab. 1986 Jan; 62(1):102-8.
Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free alpha-subunit secretion.
Hodin RA, Lazar MA, Wintman BI, Darling DS, Koenig RJ, Larsen PR, Moore DD, Chin WW
Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 07; 244(4900):76-9.
Identification of a thyroid hormone receptor that is pituitary-specific.
Mirell CJ, Lau R, Huaco M, Pekary AE, Chin WW, Hershman JM
Differential expression of thyrotropin hormone genes by GH3 cells and the normal rat pituitary. Mol Cell Endocrinol. 1986 Sep; 47(1-2):145-51.
Differential expression of thyrotropin hormone genes by GH3 cells and the normal rat pituitary.
Chin WW, Habener JF, Martorana MA, Keutmann HT, Kieffer JD, Maloof F
Thyroid-stimulating hormone: isolation and partial characterization of hormone and subunits from a mouse thyrotrope tumor. Endocrinology. 1980 Nov; 107(5):1384-92.
Thyroid-stimulating hormone: isolation and partial characterization of hormone and subunits from a mouse thyrotrope tumor.
Thyroid-stimulating hormone subunits: evidence from endoglycosidase-H cleavage for late presecretory glycosylation. Endocrinology. 1981 May; 108(5):1628-33.
Thyroid-stimulating hormone subunits: evidence from endoglycosidase-H cleavage for late presecretory glycosylation.
Kaplan LM, Gabriel SM, Koenig JI, Sunday ME, Spindel ER, Martin JB, Chin WW
Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7408-12.
Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization. Eur J Pharm Biopharm. 2010 Oct; 76(2):245-52.
Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization.
How to revive breakthrough innovation in the pharmaceutical industry. Sci Transl Med. 2011 Jun 29; 3(89):89cm16.
How to revive breakthrough innovation in the pharmaceutical industry.
Sunday ME, Wolfe HJ, Roos BA, Chin WW, Spindel ER
Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells. Endocrinology. 1988 Apr; 122(4):1551-8.
Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells.
Shupnik MA, Chin WW, Habener JF, Ridgway EC
Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem. 1985 Mar 10; 260(5):2900-3.
Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone.
Difference in sizes of human compared to murine alpha-subunits of the glycoprotein hormones arises by four-codon gene deletion or insertion. Endocrinology. 1983 Feb; 112(2):482-5.
Difference in sizes of human compared to murine alpha-subunits of the glycoprotein hormones arises by four-codon gene deletion or insertion.
Yen PM, Sugawara A, Liu Y, Whang J, Chin WW
Factors that enhance Escherichia coli-expressed TR beta binding to T3 and DNA. Thyroid. 1995 Aug; 5(4):309-13.
Factors that enhance Escherichia coli-expressed TR beta binding to T3 and DNA.
A potential transcriptional adaptor(s) may be required in thyroid hormone-stimulated gene transcription in vitro. Endocrinology. 1995 Jun; 136(6):2776-83.
A potential transcriptional adaptor(s) may be required in thyroid hormone-stimulated gene transcription in vitro.
Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM
Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 1994 Jul; 135(1):315-20.
Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein.
Evidence that the hepatotoxicity of N-nitrosodimethylamine in the rat is unrelated to DNA methylation. Chem Res Toxicol. 1993 May-Jun; 6(3):372-5.
Evidence that the hepatotoxicity of N-nitrosodimethylamine in the rat is unrelated to DNA methylation.
Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW
A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12280-4.
A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone.
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase. J Clin Invest. 1996 Apr 15; 97(8):1884-9.
Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase.
Saw CL, Olivo M, Chin WW, Soo KC, Heng PW
Journal of photochemistry and photobiology. B, Biology
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. J Photochem Photobiol B. 2007 Mar 01; 86(3):207-18.
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.
Regulation of thyroid hormone receptor beta-2 mRNA levels by retinoic acid. Mol Cell Endocrinol. 1993 Feb; 91(1-2):113-8.
Regulation of thyroid hormone receptor beta-2 mRNA levels by retinoic acid.
Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW, Soo KC
Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. J Environ Pathol Toxicol Oncol. 2008; 27(1):35-42.
Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy.
Leedman PJ, Stein AR, Chin WW, Rogers JT
Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element. J Biol Chem. 1996 May 17; 271(20):12017-23.
Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element.
Abbot SD, Docherty K, Roberts JL, Tepper MA, Chin WW, Clayton RN
Castration increases luteinizing hormone subunit messenger RNA levels in male rat pituitaries. J Endocrinol. 1985 Nov; 107(2):R1-4.
Castration increases luteinizing hormone subunit messenger RNA levels in male rat pituitaries.
Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Décimo D, Krezel W, Dierich A, Chambon P
Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 1996 Jan 01; 10(1):80-92.
Abnormal spermatogenesis in RXR beta mutant mice.
Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum. Endocrinology. 1999 Sep; 140(9):3955-61.
Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum.
Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW
Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest. 1987 Oct; 80(4):1172-9.
Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung.
Ridgway EC, Kieffer JD, Ross DS, Downing M, Mover H, Chin WW
Mouse pituitary tumor line secreting only the alpha-subunit of the glycoprotein hormones: development from a thyrotropic tumor. Endocrinology. 1983 Nov; 113(5):1587-91.
Mouse pituitary tumor line secreting only the alpha-subunit of the glycoprotein hormones: development from a thyrotropic tumor.
Ross DS, Downing MF, Chin WW, Kieffer JD, Ridgway EC
Changes in tissue concentrations of thyrotropin, free thyrotropin beta, and alpha-subunits after thyroxine administration: comparison of mouse hypothyroid pituitary and thyrotropic tumors. Endocrinology. 1983 Jun; 112(6):2050-3.
Changes in tissue concentrations of thyrotropin, free thyrotropin beta, and alpha-subunits after thyroxine administration: comparison of mouse hypothyroid pituitary and thyrotropic tumors.
Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. J Biol Chem. 1994 Oct 14; 269(41):25865-70.
Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells.
Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM
Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 1994 Nov; 135(5):2220-7.
Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid.
Nomenclature of thyroid hormone receptor-beta gene mutations in resistance to thyroid hormone: consensus statement from the First Workshop on Thyroid Hormone Resistance, 10-11th July 1993, Cambridge, UK. Eur J Endocrinol. 1994 Apr; 130(4):426-8.
Nomenclature of thyroid hormone receptor-beta gene mutations in resistance to thyroid hormone: consensus statement from the First Workshop on Thyroid Hormone Resistance, 10-11th July 1993, Cambridge, UK.
Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. Endocrinology. 1993 Sep; 133(3):965-71.
Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors.
Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1. J Biol Chem. 1996 Mar 22; 271(12):6645-50.
Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1.
Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1. J Biol Chem. 2002 Mar 15; 277(11):8898-905.
Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1.
Molecular and clinical evidence for the unique nature of individual selective estrogen receptor modulators. Clin Obstet Gynecol. 2003 Jun; 46(2):265-97.
Molecular and clinical evidence for the unique nature of individual selective estrogen receptor modulators.
Bettoun DJ, Lu J, Khalifa B, Yee Y, Chin WW, Nagpal S
The Journal of steroid biochemistry and molecular biology
Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):195-8.
Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner.
Differential regulation of thyroid hormone receptor messenger ribonucleic acid levels by thyrotropin-releasing hormone. Endocrinology. 1991 Apr; 128(4):1763-8.
Differential regulation of thyroid hormone receptor messenger ribonucleic acid levels by thyrotropin-releasing hormone.
Thyroid hormone decreases the stability and the poly(A) tract length of rat thyrotropin beta-subunit messenger RNA. Mol Endocrinol. 1991 Apr; 5(4):469-75.
Thyroid hormone decreases the stability and the poly(A) tract length of rat thyrotropin beta-subunit messenger RNA.
Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements. Endocrinology. 1991 Dec; 129(6):3331-6.
Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements.
Spindel ER, Chin WW, Price J, Rees LH, Besser GM, Habener JF
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5699-703.
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.
Jacobs JW, Goodman RH, Chin WW, Dee PC, Habener JF, Bell NH, Potts JT
Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24; 213(4506):457-9.
Calcitonin messenger RNA encodes multiple polypeptides in a single precursor.
Naylor SL, Sakaguchi AY, McDonald L, Todd S, Lalley PA, Shows TB, Chin WW
Mapping thyrotropin beta subunit gene in man and mouse. Somat Cell Mol Genet. 1986 May; 12(3):307-11.
Mapping thyrotropin beta subunit gene in man and mouse.
The polypeptides of adenovirus. VII. Further studies of early polypeptides in vivo and localization of E2 and E2A to the cell plasma membrane. Virology. 1976 Jun; 71(2):518-30.
The polypeptides of adenovirus. VII. Further studies of early polypeptides in vivo and localization of E2 and E2A to the cell plasma membrane.
Kaiser UB, Dushkin H, Altherr MR, Beier DR, Chin WW
Chromosomal localization of the gonadotropin-releasing hormone receptor gene to human chromosome 4q13.1-q21.1 and mouse chromosome 5. Genomics. 1994 Apr; 20(3):506-8.
Chromosomal localization of the gonadotropin-releasing hormone receptor gene to human chromosome 4q13.1-q21.1 and mouse chromosome 5.
Sugawara A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW
Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA. J Biol Chem. 1994 Jan 07; 269(1):433-7.
Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA.
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Klibanski A, Milbury PE, Chin WW, Ridgway EC
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Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines.
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A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 Aug; 7(2):273-82.
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
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Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain.
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ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.
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Isolation and characterization of the 5'-flanking region of the mouse gonadotropin-releasing hormone receptor gene.
Koibuchi N, Gibbs RB, Jones KE, Yamaoka S, Chin WW, Pfaff DW, Suzuki M
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Corresponding Member of the Faculty of Medicine
Associate Professor of Medicine, Part-time
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
Assistant Professor of Medicine, Part-time
David G. Nathan Distinguished Professor of Pediatrics
Stanley J. Korsmeyer Professor of Cell Biology and Medicine
Harvard University Distinguished Service Professor
C.C. Wang Professor of Radiation Oncology, Emerita
The Human Touch - Addressing Health Care's Workforce Problem amid the Pandemic. N Engl J Med. 2020 Oct 29; 383(18):e102.
The Human Touch - Addressing Health Care's Workforce Problem amid the Pandemic.
Yu L, Iwasaki T, Xu M, Lesmana R, Xiong Y, Shimokawa N, Chin WW, Koibuchi N
Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells. Endocrinology. 2015 Apr; 156(4):1565-76.
Aberrant cerebellar development of transgenic mice expressing dominant-negative thyroid hormone receptor in cerebellar Purkinje cells.
Optimizing the Role of Academia in Regulatory Science
Reproductive Physiology of Gonadotropin Synthesis
MECHANISMS OF NUCLEAR THYROID HORMONE ACTION
Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW
Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology. 1996 Aug; 137(8):3594-7.
Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.
Citation for the 1996 Ernst Oppenheimer Memorial Award of The Endocrine Society to Keith L. Parker. Endocr Rev. 1996 Aug; 17(4):414-5.
Citation for the 1996 Ernst Oppenheimer Memorial Award of The Endocrine Society to Keith L. Parker.
Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW, Meier CA
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology. 1996 Oct; 137(10):4499-502.
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.
Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity. J Biol Chem. 1996 Sep 20; 271(38):23096-104.
Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity.
Penabad JL, Bashey HM, Asa SL, Haddad G, Davis KD, Herbst AB, Gennarelli TA, Kaiser UB, Chin WW, Snyder PJ
Decreased follistatin gene expression in gonadotroph adenomas. J Clin Endocrinol Metab. 1996 Sep; 81(9):3397-403.
Decreased follistatin gene expression in gonadotroph adenomas.
Estrogen and thyroid hormone interaction on regulation of gene expression. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12587-92.
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Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.
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Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro.
Saunders BD, Sabbagh E, Chin WW, Kaiser UB
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Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression.
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Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development. Endocrinology. 1999 Apr; 140(4):1957-60.
Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development.
The gonadotropin-releasing hormone receptor gene promoter directs pituitary-specific oncogene expression in transgenic mice. Endocrinology. 1999 May; 140(5):2415-21.
The gonadotropin-releasing hormone receptor gene promoter directs pituitary-specific oncogene expression in transgenic mice.
Identification of Reverb(alpha) as a novel ROR(alpha) target gene. J Biol Chem. 2002 Sep 20; 277(38):35013-8.
Identification of Reverb(alpha) as a novel ROR(alpha) target gene.
Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff D
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Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms.
Liu Y, Takeshita A, Nagaya T, Baniahmad A, Chin WW, Yen PM
An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. Mol Endocrinol. 1998 Jan; 12(1):34-44.
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Message from the president of the American Thyroid Association.
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Ligand-binding and heterodimerization activities of a conserved region in the ligand-binding domain of the thyroid hormone receptor.
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Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. J Biol Chem. 1998 May 22; 273(21):12943-51.
Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene.
Hosler BA, Sapp PC, Berger R, O'Neill G, Bejaoui K, Hamida MB, Hentati F, Chin W, McKenna-Yasek D, Haines JL, Patterson D, Horvitz HR, Brown RH, Day CB
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33. Neurogenetics. 1998 Dec; 2(1):34-42.
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33.
Zhang P, Chin W, Chow LT, Chan AS, Yim AP, Leung SF, Mok TS, Chang KS, Johnson PJ, Chan JY
Lack of expression for the suppressor PML in human small cell lung carcinoma. Int J Cancer. 2000 Mar 01; 85(5):599-605.
Lack of expression for the suppressor PML in human small cell lung carcinoma.
Promoter-Specific Regulation of the Brain-Derived Neurotropic Factor Gene by Thyroid Hormone in the Developing Rat Cerebellum1. Endocrinology. 1999 Sep 01; 140(9):3955-3961.
Promoter-Specific Regulation of the Brain-Derived Neurotropic Factor Gene by Thyroid Hormone in the Developing Rat Cerebellum1.
Coactivator and Corepressor Gene Expression in Rat Cerebellum during Postnatal Development and the Effect of Altered Thyroid Status. Endocrinology. 2000 May 01; 141(5):1693-1698.
Coactivator and Corepressor Gene Expression in Rat Cerebellum during Postnatal Development and the Effect of Altered Thyroid Status.
Norwitz ER, Xu S, Jeong KH, Be de Carrats GG, Winebrenner LD, Chin WW, Kaiser UB
Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene. Endocrinology. 2002 Mar 01; 143(3):985-997.
Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene.
Expression and Hormonal Regulation of Coactivator and Corepressor Genes. Endocrinology. 1998 May 01; 139(5):2493-2500.
Expression and Hormonal Regulation of Coactivator and Corepressor Genes.
Kaiser UB, Sabbagh E, Saunders BD, Chin WW
Identification of cis-Acting Deoxyribonucleic Acid Elements That Mediate Gonadotropin-Releasing Hormone Stimulation of the Rat Luteinizing Hormone ß-Subunit Gene. Endocrinology. 1998 May 01; 139(5):2443-2451.
Identification of cis-Acting Deoxyribonucleic Acid Elements That Mediate Gonadotropin-Releasing Hormone Stimulation of the Rat Luteinizing Hormone ß-Subunit Gene.
RORa Augments Thyroid Hormone Receptor-Mediated Transcriptional Activation. Endocrinology. 1999 Mar 01; 140(3):1356-1364.
RORa Augments Thyroid Hormone Receptor-Mediated Transcriptional Activation.
RORa Gene Expression in the Perinatal Rat Cerebellum: Ontogeny and Thyroid Hormone Regulation. Endocrinology. 1998 May 01; 139(5):2335-2341.
RORa Gene Expression in the Perinatal Rat Cerebellum: Ontogeny and Thyroid Hormone Regulation.
The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol. 1999 Jan; 13(1):106-16.
The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1.
Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements. Endocrinology. 2000 Mar; 141(3):1281-4.
Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements.
Biochemical and biophysical research communications
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Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor.
Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC, Lynch DH
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999 Feb; 5(2):157-63.
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J Biol Chem. 2001 Sep 07; 276(36):33375-83.
Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).
Vasudevan N, Koibuchi N, Chin WW, Pfaff DW
Brain research. Molecular brain research
Differential crosstalk between estrogen receptor (ER)alpha and ERbeta and the thyroid hormone receptor isoforms results in flexible regulation of the consensus ERE. Brain Res Mol Brain Res. 2001 Nov 01; 95(1-2):9-17.
Differential crosstalk between estrogen receptor (ER)alpha and ERbeta and the thyroid hormone receptor isoforms results in flexible regulation of the consensus ERE.
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A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand. J Biol Chem. 2002 Jul 12; 277(28):24847-50.
A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW
TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997 Oct 31; 272(44):27629-34.
TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
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Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol. 2002 Jan; 22(1):357-69.
Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.
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Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas.
Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor. J Biol Chem. 2003 Jan 24; 278(4):2403-10.
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Bettoun DJ, Burris TP, Houck KA, Buck DW, Stayrook KR, Khalifa B, Lu J, Chin WW, Nagpal S
Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov; 17(11):2320-8.
Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.
Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: biodistribution, light dose and drug-light interval effects. Int J Oncol. 2004 Sep; 25(3):623-9.
Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: biodistribution, light dose and drug-light interval effects.
Corrigan AZ, Bilezikjian LM, Carroll RS, Bald LN, Schmelzer CH, Fendly BM, Mason AJ, Chin WW, Schwall RH, Vale W
Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology. 1991 Mar; 128(3):1682-4.
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Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol Pharm Bull. 2005 Jun; 28(6):1054-60.
Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment.
Gharib SD, Wierman ME, Shupnik MA, Chin WW
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3,5,3'-triiodothyronine receptor auxiliary protein (TRAP) enhances receptor binding by interactions within the thyroid hormone response element.
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Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.
Zhao D, Yang J, Jones KE, Gerald C, Suzuki Y, Hogan PG, Chin WW, Tashjian AH
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Spanjaard RA, Ikeda M, Lee PJ, Charpentier B, Chin WW, Eberlein TJ
Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells. J Biol Chem. 1997 Jul 25; 272(30):18990-9.
Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells.
Carroll RS, Kowash PM, Lofgren JA, Schwall RH, Chin WW
In vivo regulation of FSH synthesis by inhibin and activin. Endocrinology. 1991 Dec; 129(6):3299-304.
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Perry WL, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 01; 65(15):6593-600.
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
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Binding of thyroid hormone receptors to the rat thyrotropin-beta gene.
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Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov; 9(6):757-70.
Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse.
Leonard JL, Farwell AP, Yen PM, Chin WW, Stula M
Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. Endocrinology. 1994 Aug; 135(2):548-55.
Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells.
Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary. J Clin Invest. 1993 Jun; 91(6):2523-31.
Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary.
Kaplan LM, Spindel ER, Isselbacher KJ, Chin WW
Tissue-specific expression of the rat galanin gene. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1065-9.
Tissue-specific expression of the rat galanin gene.
Takeshita A, Yen PM, Ikeda M, Cardona GR, Liu Y, Koibuchi N, Norwitz ER, Chin WW
Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. J Biol Chem. 1998 Aug 21; 273(34):21554-62.
Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1.
Yen PM, Liu Y, Palvimo JJ, Trifiro M, Whang J, Pinsky L, Jänne OA, Chin WW
Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription. Mol Endocrinol. 1997 Feb; 11(2):162-71.
Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription.
Halvorson LM, Ito M, Jameson JL, Chin WW
Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. J Biol Chem. 1998 Jun 12; 273(24):14712-20.
Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression.
Ikeda M, Kawaguchi A, Takeshita A, Chin WW, Endo T, Onaya T
CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation. Mol Cell Endocrinol. 1999 Jan 25; 147(1-2):103-12.
CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation.
Kia HK, Krebs CJ, Koibuchi N, Chin WW, Pfaff DW
Co-expression of estrogen and thyroid hormone receptors in individual hypothalamic neurons. J Comp Neurol. 2001 Aug 27; 437(3):286-95.
Co-expression of estrogen and thyroid hormone receptors in individual hypothalamic neurons.
Yen PM, Darling DS, Carter RL, Forgione M, Umeda PK, Chin WW
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers. J Biol Chem. 1992 Feb 25; 267(6):3565-8.
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.
Scott RE, Wu-Peng XS, Yen PM, Chin WW, Pfaff DW
Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE. Mol Endocrinol. 1997 Oct; 11(11):1581-92.
Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE.
Hormonal regulation of thyrotropin and gonadotropin gene expression. Clin Res. 1988 Sep; 36(5):484-93.
Hormonal regulation of thyrotropin and gonadotropin gene expression.
Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM
Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. Endocrinology. 1998 Oct; 139(10):4197-204.
Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.
Spindel ER, Eipper BA, Zilberberg MD, Mains RE, Chin WW
Cerulein mRNA and peptide alpha-amidation activity in the skin of Xenopus laevis: stimulation by norepinephrine. Gen Comp Endocrinol. 1987 Jul; 67(1):67-76.
Cerulein mRNA and peptide alpha-amidation activity in the skin of Xenopus laevis: stimulation by norepinephrine.
Decreased serum free thyroxine concentration in patients treated with diphenylhydantoin. J Clin Endocrinol Metab. 1968 Feb; 28(2):181-6.
Decreased serum free thyroxine concentration in patients treated with diphenylhydantoin.
Shupnik MA, Chin WW, Ross DS, Downing MF, Habener JF, Ridgway EC
Regulation by thyroxine of the mRNA encoding the alpha subunit of mouse thyrotropin. J Biol Chem. 1983 Dec 25; 258(24):15120-4.
Regulation by thyroxine of the mRNA encoding the alpha subunit of mouse thyrotropin.
Chin WW, Goodman RH, Jacobs JW, Wolfe HJ, Daniels GH, Habener JF
Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin. J Clin Endocrinol Metab. 1981 Mar; 52(3):572-5.
Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin.
Hayashi Y, Weiss RE, Sarne DH, Yen PM, Sunthornthepvarakul T, Marcocci C, Chin WW, Refetoff S
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? J Clin Endocrinol Metab. 1995 Nov; 80(11):3246-56.
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors?
Darling DS, Carter RL, Yen PM, Welborn JM, Chin WW, Umeda PK
Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. J Biol Chem. 1993 May 15; 268(14):10221-7.
Different dimerization activities of alpha and beta thyroid hormone receptor isoforms.
Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene. Endocrinology. 1998 May; 139(5):2443-51.
Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene.