Harlow, Ed
completed student projects: Localization of PRB-Repressed Promoters in Relation to PRB Nuclear FOCI in Confluent Human Fibroblasts
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first name: Ed
last name: Harlow
coauthor of: Dyson, Nicholas
coauthor of: Vidal, Marc
coauthor of: Haber, Daniel
coauthor of: Meyerson, Matthew
coauthor of: Barbie, David
full name: Ed Harlow, Ph.D.
has faculty rank: Full Professor
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latitude: 42.33588600000000
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Person ID: 24867
person in primary position: Virginia and D.K. Ludwig Professor of Cancer Research and Teaching
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similar to: Dyson, Nicholas
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selected publications: Authorship 719054
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No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice.
PubMed Identifier: 10449036
author list: Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ
published in: Molecular carcinogenesis
information resource reference: No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog. 1999 Aug; 25(4):295-303.
journal title abbreviation: Mol Carcinog
publication date: 1999-08-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Interaction between human cyclin A and adenovirus E1A-associated p107 protein.
PubMed Identifier: 1532458
author list: Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E
published in: Science (New York, N.Y.)
information resource reference: Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science. 1992 Jan 03; 255(5040):87-90.
journal title abbreviation: Science
publication date: 1992-01-03T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
PubMed Identifier: 1717832
author list: Hu QJ, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E
published in: Molecular and cellular biology
information resource reference: Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol Cell Biol. 1991 Nov; 11(11):5792-9.
journal title abbreviation: Mol Cell Biol
publication date: 1991-11-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.
PubMed Identifier: 6177872
author list: Crawford L, Leppard K, Lane D, Harlow E
published in: Journal of virology
information resource reference: Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen. J Virol. 1982 May; 42(2):612-20.
journal title abbreviation: J Virol
publication date: 1982-05-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

p16 inhibition of transformed and primary squamous epithelial cells.
PubMed Identifier: 8649826
author list: Enders GH, Koh J, Missero C, Rustgi AK, Harlow E
published in: Oncogene
information resource reference: p16 inhibition of transformed and primary squamous epithelial cells. Oncogene. 1996 Mar 21; 12(6):1239-45.
journal title abbreviation: Oncogene
publication date: 1996-03-21T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Shared role of the pRB-related p130 and p107 proteins in limb development.
PubMed Identifier: 8682294
author list: Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T
published in: Genes & development
information resource reference: Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 01; 10(13):1633-44.
journal title abbreviation: Genes Dev
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs.
PubMed Identifier: 9010227
author list: Zarkowska T, U S, Harlow E, Mittnacht S
published in: Oncogene
information resource reference: Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene. 1997 Jan 16; 14(2):249-54.
journal title abbreviation: Oncogene
publication date: 1997-01-16T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
PubMed Identifier: 1398067
author list: Lees E, Faha B, Dulic V, Reed SI, Harlow E
published in: Genes & development
information resource reference: Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 1992 Oct; 6(10):1874-85.
journal title abbreviation: Genes Dev
publication date: 1992-10-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.
PubMed Identifier: 9724724
author list: Schulman BA, Lindstrom DL, Harlow E
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10453-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1998-09-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1.
PubMed Identifier: 8668186
author list: Wu CL, Classon M, Dyson N, Harlow E
published in: Molecular and cellular biology
information resource reference: Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol. 1996 Jul; 16(7):3698-706.
journal title abbreviation: Mol Cell Biol
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The retinoblastoma tumour suppressor in development and cancer.
PubMed Identifier: 12459729
author list: Classon M, Harlow E
published in: Nature reviews. Cancer
information resource reference: The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer. 2002 Dec; 2(12):910-7.
journal title abbreviation: Nat Rev Cancer
publication date: 2002-12-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability.
PubMed Identifier: 20713694
author list: Conery AR, Harlow E
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15455-60.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-08-16T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of adenovirus early-region 1A proteins with cellular polypeptides.
PubMed Identifier: 2431282
author list: Harlow E, Whyte P, Franza BR, Schley C
published in: Molecular and cellular biology
information resource reference: Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol. 1986 May; 6(5):1579-89.
journal title abbreviation: Mol Cell Biol
publication date: 1986-05-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.
PubMed Identifier: 2570639
author list: Giordano A, Whyte P, Harlow E, Franza BR, Beach D, Draetta G
published in: Cell
information resource reference: A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell. 1989 Sep 08; 58(5):981-90.
journal title abbreviation: Cell
publication date: 1989-09-08T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells.
PubMed Identifier: 6253132
author list: Crawford LV, Lane DP, Denhardt DT, Harlow EE, Nicklin PM, Osborn K, Pim DC
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:179-87.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1980-01-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
PubMed Identifier: 7958856
author list: Dynlacht BD, Flores O, Lees JA, Harlow E
published in: Genes & development
information resource reference: Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 1994 Aug 01; 8(15):1772-86.
journal title abbreviation: Genes Dev
publication date: 1994-08-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
PubMed Identifier: 17322287
author list: Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J
published in: Genome research
information resource reference: Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr; 17(4):536-43.
journal title abbreviation: Genome Res
publication date: 2007-02-23T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
PubMed Identifier: 21498571
author list: Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N
published in: Genes & development
information resource reference: A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30.
journal title abbreviation: Genes Dev
publication date: 2011-04-15T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105301
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Nuclear organization of DNA replication in primary mammalian cells.
PubMed Identifier: 11090133
author list: Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E
published in: Genes & development
information resource reference: Nuclear organization of DNA replication in primary mammalian cells. Genes Dev. 2000 Nov 15; 14(22):2855-68.
journal title abbreviation: Genes Dev
publication date: 2000-11-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.
PubMed Identifier: 7774910
author list: Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT
published in: Genomics
information resource reference: Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics. 1995 Jan 01; 25(1):130-8.
journal title abbreviation: Genomics
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 108047
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.

Cellular proteins that are targets for transformation by DNA tumour viruses.
PubMed Identifier: 2142644
author list: Buchkovich K, Dyson N, Whyte P, Harlow E
published in: Ciba Foundation symposium
information resource reference: Cellular proteins that are targets for transformation by DNA tumour viruses. Ciba Found Symp. 1990; 150:262-71; discussion 271-8.
journal title abbreviation: Ciba Found Symp
publication date: 1990-01-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.
PubMed Identifier: 2968522
author list: Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RA, Harlow E
published in: Nature
information resource reference: Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature. 1988 Jul 14; 334(6178):124-9.
journal title abbreviation: Nature
publication date: 1988-07-14T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.
PubMed Identifier: 3023660
author list: Pallas DC, Schley C, Mahoney M, Harlow E, Schaffhausen BS, Roberts TM
published in: Journal of virology
information resource reference: Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production. J Virol. 1986 Dec; 60(3):1075-84.
journal title abbreviation: J Virol
publication date: 1986-12-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells.
PubMed Identifier: 6246255
author list: McCormick F, Harlow E
published in: Journal of virology
information resource reference: Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol. 1980 Apr; 34(1):213-24.
journal title abbreviation: J Virol
publication date: 1980-04-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells.
PubMed Identifier: 6163871
author list: Harlow E, Pim DC, Crawford LV
published in: Journal of virology
information resource reference: Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells. J Virol. 1981 Feb; 37(2):564-73.
journal title abbreviation: J Virol
publication date: 1981-02-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
PubMed Identifier: 8405995
author list: Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E
published in: Genes & development
information resource reference: Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 1993 Oct; 7(10):1850-61.
journal title abbreviation: Genes Dev
publication date: 1993-10-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of small molecule inhibitors of pyruvate kinase M2.
PubMed Identifier: 20005212
author list: Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC
published in: Biochemical pharmacology
information resource reference: Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol. 2010 Apr 15; 79(8):1118-24.
journal title abbreviation: Biochem Pharmacol
publication date: 2009-12-11T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen.
PubMed Identifier: 18948595
author list: Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin WG, Grueneberg DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16484-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-10-23T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Cellular proteins that are targetted by DNA tumor viruses for transformation.
PubMed Identifier: 2488232
author list: Dyson N, Buchkovich K, Whyte P, Harlow E
published in: Princess Takamatsu symposia
information resource reference: Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu Symp. 1989; 20:191-8.
journal title abbreviation: Princess Takamatsu Symp
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells.
PubMed Identifier: 6315411
author list: Leppard K, Totty N, Waterfield M, Harlow E, Jenkins J, Crawford L
published in: The EMBO journal
information resource reference: Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells. EMBO J. 1983; 2(11):1993-9.
journal title abbreviation: EMBO J
publication date: 1983-01-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
PubMed Identifier: 8413249
author list: Helin K, Harlow E, Fattaey A
published in: Molecular and cellular biology
information resource reference: Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol. 1993 Oct; 13(10):6501-8.
journal title abbreviation: Mol Cell Biol
publication date: 1993-10-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Tumor induction and tissue atrophy in mice lacking E2F-1.
PubMed Identifier: 8653789
author list: Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ
published in: Cell
information resource reference: Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996 May 17; 85(4):537-48.
journal title abbreviation: Cell
publication date: 1996-05-17T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 103015
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

In vivo association of E2F and DP family proteins.
PubMed Identifier: 7739537
author list: Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA
published in: Molecular and cellular biology
information resource reference: In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995 May; 15(5):2536-46.
journal title abbreviation: Mol Cell Biol
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted disruption of p107: functional overlap between p107 and Rb.
PubMed Identifier: 8682293
author list: Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T
published in: Genes & development
information resource reference: Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 01; 10(13):1621-32.
journal title abbreviation: Genes Dev
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of the retinoblastoma binding proteins RBP1 and RBP2.
PubMed Identifier: 8414517
author list: Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D
published in: Oncogene
information resource reference: Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov; 8(11):3149-56.
journal title abbreviation: Oncogene
publication date: 1993-11-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Purification and analysis of CIP/KIP proteins.
PubMed Identifier: 9251023
author list: Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW
published in: Methods in enzymology
information resource reference: Purification and analysis of CIP/KIP proteins. Methods Enzymol. 1997; 283:230-44.
journal title abbreviation: Methods Enzymol
publication date: 1997-01-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcriptional inhibition by the retinoblastoma protein.
PubMed Identifier: 8103936
author list: Fattaey A, Helin K, Harlow E
published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
information resource reference: Transcriptional inhibition by the retinoblastoma protein. Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29; 340(1293):333-6.
journal title abbreviation: Philos Trans R Soc Lond B Biol Sci
publication date: 1993-06-29T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

A research shortcut from a common cold virus to human cancer.
PubMed Identifier: 8697405
author list: Harlow E
published in: Cancer
information resource reference: A research shortcut from a common cold virus to human cancer. Cancer. 1996 Aug 01; 78(3):558-65.
journal title abbreviation: Cancer
publication date: 1996-08-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.
PubMed Identifier: 8704183
author list: Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL
published in: Blood
information resource reference: Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood. 1996 Jul 01; 88(1):268-76.
journal title abbreviation: Blood
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.
PubMed Identifier: 2673543
author list: Buchkovich K, Duffy LA, Harlow E
published in: Cell
information resource reference: The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell. 1989 Sep 22; 58(6):1097-105.
journal title abbreviation: Cell
publication date: 1989-09-22T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Growth suppression by members of the retinoblastoma protein family.
PubMed Identifier: 7587134
author list: Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Growth suppression by members of the retinoblastoma protein family. Cold Spring Harb Symp Quant Biol. 1994; 59:75-84.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
PubMed Identifier: 8246949
author list: Fattaey AR, Harlow E, Helin K
published in: Molecular and cellular biology
information resource reference: Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol. 1993 Dec; 13(12):7267-77.
journal title abbreviation: Mol Cell Biol
publication date: 1993-12-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.
PubMed Identifier: 8502482
author list: Tsai LH, Lees E, Faha B, Harlow E, Riabowol K
published in: Oncogene
information resource reference: The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene. 1993 Jun; 8(6):1593-602.
journal title abbreviation: Oncogene
publication date: 1993-06-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.
PubMed Identifier: 12080086
author list: Fingar DC, Salama S, Tsou C, Harlow E, Blenis J
published in: Genes & development
information resource reference: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002 Jun 15; 16(12):1472-87.
journal title abbreviation: Genes Dev
publication date: 2002-06-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
PubMed Identifier: 15210943
author list: Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9677-82.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-06-21T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.
PubMed Identifier: 8386263
author list: Faha B, Harlow E, Lees E
published in: Journal of virology
information resource reference: The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J Virol. 1993 May; 67(5):2456-65.
journal title abbreviation: J Virol
publication date: 1993-05-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
PubMed Identifier: 8090221
author list: Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E
published in: Nature
information resource reference: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994 Sep 29; 371(6496):419-23.
journal title abbreviation: Nature
publication date: 1994-09-29T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The retinoblastoma protein binds to a family of E2F transcription factors.
PubMed Identifier: 8246996
author list: Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K
published in: Molecular and cellular biology
information resource reference: The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993 Dec; 13(12):7813-25.
journal title abbreviation: Mol Cell Biol
publication date: 1993-12-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.
PubMed Identifier: 2546678
author list: Dyson N, Buchkovich K, Whyte P, Harlow E
published in: Cell
information resource reference: The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell. 1989 Jul 28; 58(2):249-55.
journal title abbreviation: Cell
publication date: 1989-07-28T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene.
PubMed Identifier: 7730357
author list: Wade M, Blake MC, Jambou RC, Helin K, Harlow E, Azizkhan JC
published in: The Journal of biological chemistry
information resource reference: An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene. J Biol Chem. 1995 Apr 28; 270(17):9783-91.
journal title abbreviation: J Biol Chem
publication date: 1995-04-28T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
PubMed Identifier: 8319904
author list: Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E
published in: Genes & development
information resource reference: Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 1993 Jul; 7(7A):1111-25.
journal title abbreviation: Genes Dev
publication date: 1993-07-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.
PubMed Identifier: 11447271
author list: Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8720-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-07-10T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.
PubMed Identifier: 3894933
author list: Harlow E, Williamson NM, Ralston R, Helfman DM, Adams TE
published in: Molecular and cellular biology
information resource reference: Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol. 1985 Jul; 5(7):1601-10.
journal title abbreviation: Mol Cell Biol
publication date: 1985-07-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.
PubMed Identifier: 7743997
author list: Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E
published in: The EMBO journal
information resource reference: The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 1995 May 01; 14(9):1904-13.
journal title abbreviation: EMBO J
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Cyclins
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Cell Cycle Proteins
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MGH Cancer Center Research
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Oncogene Proteins, Viral
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Cyclin-Dependent Kinases
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Retinoblastoma Protein
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number of authors: 269
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Genetics
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Medicine
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Adult Oncology
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Oncology
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Haber, Daniel
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Gregor Mendel Professor of Genetics and of Medicine
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linked information resource: Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

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Authorship 224411
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author rank in publication: 8
linked author: Harlow, Ed
linked information resource: New functional activities for the p21 family of CDK inhibitors.

Authorship 255672
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Purification and analysis of CIP/KIP proteins.

Authorship 689863
type: Authorship
author rank in publication: 13
linked author: Harlow, Ed
linked information resource: Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines.

Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines.
PubMed Identifier: 23570341
author list: Demarest SJ, Gardner J, Vendel MC, Ailor E, Szak S, Huang F, Doern A, Tan X, Yang W, Grueneberg DA, Richards EJ, Endege WO, Harlow E, Koopman LA
published in: Biochemistry
information resource reference: Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines. Biochemistry. 2013 May 07; 52(18):3102-18.
journal title abbreviation: Biochemistry
publication date: 2013-04-24T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 323491
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

Authorship 206417
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: In vivo association of E2F and DP family proteins.

Authorship 282266
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.

Authorship 262328
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.

Authorship 197336
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 318300
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Proteome-scale purification of human proteins from bacteria.

Authorship 719054
type: Authorship
author rank in publication: 14
linked author: Harlow, Ed
linked information resource: GRK3 is essential for metastatic cells and promotes prostate tumor progression.

GRK3 is essential for metastatic cells and promotes prostate tumor progression.
PubMed Identifier: 24434559
author list: Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: GRK3 is essential for metastatic cells and promotes prostate tumor progression. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1521-6.
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year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 325748
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Dp1 is required for extra-embryonic development.

Authorship 96429
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

Authorship 268580
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.

Authorship 283137
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.

Authorship 292323
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

Shattuck Professor of Pathological Anatomy
is primary position: true
position in department: Immunology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Shattuck Professor of Pathological Anatomy
position in organization: Harvard Medical School

Authorship 361303
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells.

Authorship 484373
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

Authorship 352846
type: Authorship
author rank in publication: 9
linked author: Harlow, Ed
linked information resource: High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.

Authorship 247777
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.

Authorship 374688
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

Authorship 479526
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

Authorship 427503
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: The retinoblastoma protein binds to a family of E2F transcription factors.

Authorship 498875
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.

Authorship 552710
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

Authorship 530922
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

Authorship 88420
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

Authorship 302461
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

Authorship 316280
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.

Authorship 526652
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

Authorship 395315
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.

Authorship 486840
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis.

Authorship 448342
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes.

Authorship 482444
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Adenovirus E1A targets key regulators of cell proliferation.

Authorship 503212
type: Authorship
author rank in publication: 9
linked author: Harlow, Ed
linked information resource: Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

Authorship 522404
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

Authorship 207400
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.

Authorship 554452
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Tumor induction and tissue atrophy in mice lacking E2F-1.

Authorship 568725
type: Authorship
author rank in publication: 1
linked author: Harlow, Ed
linked information resource: Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

Authorship 567976
type: Authorship
author rank in publication: 1
linked author: Harlow, Ed
linked information resource: Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division.

Authorship 272824
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Adenovirus E1A is associated with a serine/threonine protein kinase.

Authorship 186907
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: pRB plays an essential role in cell cycle arrest induced by DNA damage.

Authorship 494629
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

Authorship 237920
type: Authorship
author rank in publication: 13
linked author: Harlow, Ed
linked information resource: RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.

Authorship 362778
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability.

Authorship 271476
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Distinct roles for cyclin-dependent kinases in cell cycle control.

Authorship 202289
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.

Authorship 412782
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines.

Authorship 131503
type: Authorship
author rank in publication: 21
linked author: Harlow, Ed
linked information resource: Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.

Authorship 523978
type: Authorship
author rank in publication: 1
linked author: Harlow, Ed
linked information resource: A research shortcut from a common cold virus to human cancer.

Authorship 83583
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.

Authorship 94748
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.

Authorship 264183
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: Point mutational inactivation of the retinoblastoma antioncogene.

Authorship 374438
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.

Authorship 45996
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice.

Authorship 22479
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Cyclin-dependent kinases: a family portrait.

Authorship 386980
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.

Authorship 544771
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.

Authorship 468815
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Anti-oncogenes and the negative regulation of cell growth.

Authorship 463924
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.

Authorship 335431
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.

Authorship 536058
type: Authorship
author rank in publication: 14
linked author: Harlow, Ed
linked information resource: Kinase requirements in human cells: I. Comparing kinase requirements across various cell types.

Authorship 538968
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.

Authorship 322217
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.

Authorship 392026
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Two regions of the adenovirus early region 1A proteins are required for transformation.

Authorship 434560
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.

Authorship 545529
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: The retinoblastoma protein physically associates with the human cdc2 kinase.

Authorship 385002
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.

Authorship 444702
type: Authorship
author rank in publication: 3
linked author: Harlow, Ed
linked information resource: Transcriptional inhibition by the retinoblastoma protein.

Authorship 446419
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization.

Authorship 534351
type: Authorship
author rank in publication: 8
linked author: Harlow, Ed
linked information resource: Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

Authorship 329839
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: The retinoblastoma tumour suppressor in development and cancer.

Authorship 337739
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Cellular proteins that are targetted by DNA tumor viruses for transformation.

Authorship 344644
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Cellular proteins that are targets for transformation by DNA tumour viruses.

Authorship 426977
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway.

Authorship 418213
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.

Authorship 463165
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.

Authorship 540364
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene.

Authorship 545502
type: Authorship
author rank in publication: 10
linked author: Harlow, Ed
linked information resource: Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.

Authorship 484372
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: Identification of small molecule inhibitors of pyruvate kinase M2.

Authorship 44808
type: Authorship
author rank in publication: 6
linked author: Harlow, Ed
linked information resource: The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

Localization of PRB-Repressed Promoters in Relation to PRB Nuclear FOCI in Confluent Human Fibroblasts
end date: 1999-05-01T00:00:00
start date: 1998-09-01T00:00:00
type: Mentoring - Completed Student Project
overview: Part Time/Continuation

Authorship 522633
type: Authorship
author rank in publication: 1
linked author: Harlow, Ed
linked information resource: Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells.

Full Professor
sort order: 0
type: Faculty Rank

Lecturer
sort order: 3
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 565312
type: Authorship
author rank in publication: 14
linked author: Harlow, Ed
linked information resource: Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.

Authorship 551880
type: Authorship
author rank in publication: 7
linked author: Harlow, Ed
linked information resource: A family of human cdc2-related protein kinases.

CANCER CELL MEETING-ORIGINS OF HUMAN CANCER
end date: 1991-07-14
principal investigator name: HARLOW, EDWARD E
start date: 1990-07-15
type: Grant
sponsor award id: R13CA052575

How Genetic Variation in Protein Kinases Affects Drug Response
end date: 2011-04-30
principal investigator name: HARLOW, EDWARD E
start date: 2009-07-04
type: Grant
sponsor award id: R21MH087394

ONCOGENE MEDIATED CHANGES IN CELL CYCLE CONTROL
end date: 2002-01-31
principal investigator name: HARLOW, EDWARD E
start date: 1991-02-01
type: Grant
sponsor award id: R01CA055339

Mechanisms of Breast Development and Carcinogenesis
end date: 2019-01-31
principal investigator name: WEINBERG, ROBERT A
start date: 1999-03-18
type: Grant
sponsor award id: P01CA080111

INVESTIGATION OF THE CELLULAR P300 PROTEIN
end date: 1994-05-31
principal investigator name: HARLOW, EDWARD E
start date: 1991-06-01
type: Grant
sponsor award id: R01CA054696

CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE
end date: 2003-08-31
principal investigator name: HARLOW, EDWARD E
start date: 1992-09-30
type: Grant
sponsor award id: R01CA074498

GENETICS OF CANCER AND INHERITED DISEASES
end date: 2005-06-30
principal investigator name: HARLOW, EDWARD E
start date: 1989-08-01
type: Grant
sponsor award id: T32CA009595

FUNCTION OF THE RETINOBLASTOMA PROTEIN
end date: 2005-03-31
principal investigator name: HARLOW, EDWARD E
start date: 1993-08-05
type: Grant
sponsor award id: R01CA060636

Dana-Farber/Harvard Cancer Center
end date: 2027-11-30
principal investigator name: EBERT, BENJAMIN LEVINE
start date: 1900-01-01
type: Grant
sponsor award id: P30CA006516

CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE
end date: 1996-08-31
principal investigator name: HARLOW, EDWARD E
start date: 1992-09-30
type: Grant
sponsor award id: R01GM048628

Co-Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: Mechanisms of Breast Development and Carcinogenesis

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: How Genetic Variation in Protein Kinases Affects Drug Response

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: ONCOGENE MEDIATED CHANGES IN CELL CYCLE CONTROL

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: CANCER CELL MEETING-ORIGINS OF HUMAN CANCER

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: FUNCTION OF THE RETINOBLASTOMA PROTEIN

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: INVESTIGATION OF THE CELLULAR P300 PROTEIN

Co-Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: Dana-Farber/Harvard Cancer Center

Principal Investigator
type: Researcher Role
researcher role of: Harlow, Ed
contributes to: GENETICS OF CANCER AND INHERITED DISEASES

Authorship 67409
type: Authorship
author rank in publication: 1
linked author: Harlow, Ed
linked information resource: Association of adenovirus early-region 1A proteins with cellular polypeptides.

Authorship 90821
type: Authorship
author rank in publication: 2
linked author: Harlow, Ed
linked information resource: Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

Authorship 9872
type: Authorship
author rank in publication: 8
linked author: Harlow, Ed
linked information resource: Growth suppression by members of the retinoblastoma protein family.

Authorship 450712
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.

Authorship 474480
type: Authorship
author rank in publication: 5
linked author: Harlow, Ed
linked information resource: Characterization of the retinoblastoma binding proteins RBP1 and RBP2.

Authorship 498868
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1.

240 Longwood Ave
type: Address
address line 1: Harvard Medical School
address line 2: BCMP Building C-1
address line 3: 240 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

Authorship 470586
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells.

Authorship 516341
type: Authorship
author rank in publication: 4
linked author: Harlow, Ed
linked information resource: Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.
PubMed Identifier: 8816797
author list: Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10315-20.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-09-17T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.
PubMed Identifier: 8816798
author list: Vidal M, Braun P, Chen E, Boeke JD, Harlow E
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10321-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-09-17T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.
PubMed Identifier: 8832394
author list: Magae J, Wu CL, Illenye S, Harlow E, Heintz NH
published in: Journal of cell science
information resource reference: Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci. 1996 Jul; 109 ( Pt 7):1717-26.
journal title abbreviation: J Cell Sci
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Proteome-scale purification of human proteins from bacteria.
PubMed Identifier: 11880620
author list: Braun P, Hu Y, Shen B, Halleck A, Koundinya M, Harlow E, LaBaer J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Proteome-scale purification of human proteins from bacteria. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2654-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2002-03-05T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
PubMed Identifier: 1756735
author list: Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E
published in: The EMBO journal
information resource reference: The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J. 1991 Dec; 10(13):4279-90.
journal title abbreviation: EMBO J
publication date: 1991-12-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.
PubMed Identifier: 9472014
author list: Zhao J, Dynlacht B, Imai T, Hori T, Harlow E
published in: Genes & development
information resource reference: Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998 Feb 15; 12(4):456-61.
journal title abbreviation: Genes Dev
publication date: 1998-02-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.
PubMed Identifier: 9537419
author list: Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T
published in: Nature genetics
information resource reference: Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet. 1998 Apr; 18(4):360-4.
journal title abbreviation: Nat Genet
publication date: 1998-04-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Opposing roles of pRB and p107 in adipocyte differentiation.
PubMed Identifier: 10995476
author list: Classon M, Kennedy BK, Mulloy R, Harlow E
published in: Proceedings of the National Academy of Sciences of the United States of America
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Dp1 is required for extra-embryonic development.
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Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells.
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RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.
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Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
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Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells.
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High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.
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Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.
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Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3.
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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.
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A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.
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Kinase requirements in human cells: I. Comparing kinase requirements across various cell types.
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Two regions of the adenovirus early region 1A proteins are required for transformation.
PubMed Identifier: 2960834
author list: Whyte P, Ruley HE, Harlow E
published in: Journal of virology
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journal title abbreviation: J Virol
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New functional activities for the p21 family of CDK inhibitors.
PubMed Identifier: 9106657
author list: LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E
published in: Genes & development
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journal title abbreviation: Genes Dev
publication date: 1997-04-01T00:00:00
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Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.
PubMed Identifier: 1331501
author list: Dyson N, Guida P, Münger K, Harlow E
published in: Journal of virology
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journal title abbreviation: J Virol
publication date: 1992-12-01T00:00:00
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Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.
PubMed Identifier: 1530885
author list: Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N
published in: Nature
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journal title abbreviation: Nature
publication date: 1992-01-09T00:00:00
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Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division.
PubMed Identifier: 1559240
author list: Harlow E
published in: Cancer research
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journal title abbreviation: Cancer Res
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Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.
PubMed Identifier: 14701733
author list: Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK
published in: Molecular and cellular biology
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Adenovirus E1A targets key regulators of cell proliferation.
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The retinoblastoma protein physically associates with the human cdc2 kinase.
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author list: Hu QJ, Lees JA, Buchkovich KJ, Harlow E
published in: Molecular and cellular biology
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journal title abbreviation: Mol Cell Biol
publication date: 1992-03-01T00:00:00
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