Burdett TC, Desjardins CA, Logan R, McFarland NR, Chen X, Schwarzschild MA
Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection. Biomed Chromatogr. 2013 Jan; 27(1):122-9.
Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection.
Chen X, Tagliaferro P, Kareva T, Yarygina O, Kholodilov N, Burke RE
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons. J Neurosci. 2012 Aug 15; 32(33):11299-308.
Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons.
Harvard T.H. Chan School of Public Health
Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
Yu J, Xie N, Zhu J, Qian Y, Zheng S, Chen XM
Exploring impacts of COVID-19 on city-wide taxi and ride-sourcing markets: Evidence from Ningbo, China. Transp Policy (Oxf). 2022 Jan; 115:220-238.
Exploring impacts of COVID-19 on city-wide taxi and ride-sourcing markets: Evidence from Ningbo, China.
Genetic connections between Parkinson's disease and cancer
Although Parkinson's disease (PD) and cancer are defined pathologically by neuron loss and cell overgrowth, respectively, they have been linked to some of the same gene alterations. LRRK2 mutations, the most common cause of autosomal dominant late-onset PD, are associated with an increased risk of cancer. Mutations of Parkin, a potent tumor suppressor gene, are the most common cause of autosomal recessive early-onset PD. While advances in cancer immunology are revolutionizing the treatment of cancer, there is a growing appreciation of the role of the immune system in PD. Previous and our preliminary studies support that PD and cancer-related LRRK2 and Parkin alterations can lead to dysregulated immune responses. The overall goal of the proposed study is to investigate whether and how the genetic connections between PD and cancer alter immune tolerance to dopaminergic neurons and contribute to dopaminergic neurodegeneration at the cellular, tissue, and systemic levels and in patient samples. Two specific aims will be pursued to determine whether 1) LRRK2 and Parkin alterations reprogram immune responses against dopaminergic neurons; 2) cancer-educated immune system alters dopaminergic-specific autoimmunity. Backed by exceptional expertise and resources from cancer research and neuroscience, two major disciplines that rarely crosstalk, our work strikes a balance between high risk and high return to address issues relevant to "Biology of PD-associated Genes" and "Neuro-immune Interactions". Its findings are expected to advance our understanding of the molecular events in the immune system leading to tumorigenesis in dividing cells and neurodegeneration as part of the systemic disorders in response to the same genetic triggers. These molecular insights would open new avenues for prevention and therapies for PD by offering a range of therapeutic targets, as well as the possibility that immune approaches developed in cancer will find applications in PD.
Assistant Professor of Emergency Medicine
Xia Y, Geng M, Chen Y, Sun S, Liao C, Zhu Z, Li Z, Ochieng WY, Angeloudis P, Elhajj M, Zhang L, Zeng Z, Zhang B, Gao Z, Chen XM
Understanding common human driving semantics for autonomous vehicles. Patterns (N Y). 2023 Jul 14; 4(7):100730.
Understanding common human driving semantics for autonomous vehicles.
Meet the authors: Yong Chen, Xiqun (Michael) Chen, and Ziyou Gao. Patterns (N Y). 2023 Nov 10; 4(11):100877.
Meet the authors: Yong Chen, Xiqun (Michael) Chen, and Ziyou Gao.
A multi-scale unified model of human mobility in urban agglomerations. Patterns (N Y). 2023 Nov 10; 4(11):100862.
A multi-scale unified model of human mobility in urban agglomerations.
Toward equitable, transparent, and collaborative human mobility computing for smart cities. Innovation (Camb). 2024 Sep 09; 5(5):100672.
Toward equitable, transparent, and collaborative human mobility computing for smart cities.
Data-knowledge co-driven innovations in engineering and management. Patterns (N Y). 2024 Dec 13; 5(12):101114.
Data-knowledge co-driven innovations in engineering and management.
Climate policy uncertainty and corporate carbon performance: Evidence from transportation enterprises. J Environ Manage. 2025 Aug; 390:126346.
Climate policy uncertainty and corporate carbon performance: Evidence from transportation enterprises.
Integrating large language models and affective computing for human-machine symbiosis in intelligent driving. Innovation (Camb). 2025 Dec 01; 6(12):101014.
Integrating large language models and affective computing for human-machine symbiosis in intelligent driving.
Current neurology and neuroscience reports
Urate in Parkinson's disease: more than a biomarker? Curr Neurol Neurosci Rep. 2012 Aug; 12(4):367-75.
Urate in Parkinson's disease: more than a biomarker?
Tank AW, Xu L, Chen X, Radcliffe P, Sterling CR
Annals of the New York Academy of Sciences
Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. Ann N Y Acad Sci. 2008 Dec; 1148:238-48.
Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain.
Sun B, Chen X, Xu L, Sterling C, Tank AW
Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation. Mol Pharmacol. 2004 Oct; 66(4):1011-21.
Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons: the role of transcriptional activation.
Chen X, Xu L, Radcliffe P, Sun B, Tank AW
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Mol Pharmacol. 2008 Jun; 73(6):1816-28.
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons.
Xu L, Chen X, Sun B, Sterling C, Tank AW
Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla. Brain Res. 2007 Jul 16; 1158:1-10.
Evidence for regulation of tyrosine hydroxylase mRNA translation by stress in rat adrenal medulla.
Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, Burke RE
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci. 2008 Jan 16; 28(3):672-80.
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.
Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis. Biomark Med. 2010 Oct; 4(5):701-12.
Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.
Chen X, Burdett TC, Desjardins CA, Logan R, Cipriani S, Xu Y, Schwarzschild MA
Proceedings of the National Academy of Sciences of the United States of America
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):300-5.
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.
Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, During M, Kholodilov N, Burke RE
Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. Ann Neurol. 2011 Jul; 70(1):110-20.
Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration.