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A whole lifespan mouse multi-tissue DNA methylation clock. Elife. 2018 11 14; 7.
A whole lifespan mouse multi-tissue DNA methylation clock.
Genomics perspective on disulfide bond formation. Antioxid Redox Signal. 2003 Aug; 5(4):397-402.
Genomics perspective on disulfide bond formation.
Sun QA, Su D, Novoselov SV, Carlson BA, Hatfield DL, Gladyshev VN
Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry. 2005 Nov 08; 44(44):14528-37.
Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase.
Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, Hatfield DL
Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord. 2007 Feb; 17(2):135-42.
Selenoprotein expression is essential in endothelial cell development and cardiac muscle function.
Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27; 284(9):5986-93.
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.
Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, del Conte R, Gladyshev VN, Dikiy A
1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec; 2(2):199-201.
1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2.
Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL
Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development. Molecules. 2009 Sep 10; 14(9):3509-27.
Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development.
Yoo MH, Carlson BA, Tsuji P, Irons R, Gladyshev VN, Hatfield DL
Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. Methods Enzymol. 2010; 474:255-75.
Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.
Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H
Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011 Nov 01; 15(9):2565-604.
Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.
Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN
Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12.
Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.
Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN
Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding. J Biol Chem. 2012 Jul 13; 287(29):24448-59.
Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.
Anisimova AS, Alexandrov AI, Makarova NE, Gladyshev VN, Dmitriev SE
Protein synthesis and quality control in aging. Aging (Albany NY). 2018 12 18; 10(12):4269-4288.
Protein synthesis and quality control in aging.
Gladyshev VN, Stadtman TC, Hatfield DL, Jeang KT
Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):835-9.
Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase.
Kumaraswamy E, Malykh A, Korotkov KV, Kozyavkin S, Hu Y, Kwon SY, Moustafa ME, Carlson BA, Berry MJ, Lee BJ, Hatfield DL, Diamond AM, Gladyshev VN
Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. J Biol Chem. 2000 Nov 10; 275(45):35540-7.
Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology.
Genes to cells : devoted to molecular & cellular mechanisms
Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000 Dec; 5(12):1049-60.
Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.
Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL
Genetic and functional analysis of mammalian Sep15 selenoprotein. Methods Enzymol. 2002; 347:187-97.
Genetic and functional analysis of mammalian Sep15 selenoprotein.
The prokaryotic selenoproteome. EMBO Rep. 2004 May; 5(5):538-43.
Zhang Y, Baranov PV, Atkins JF, Gladyshev VN
Pyrrolysine and selenocysteine use dissimilar decoding strategies. J Biol Chem. 2005 May 27; 280(21):20740-51.
Pyrrolysine and selenocysteine use dissimilar decoding strategies.
Novoselov SV, Calvisi DF, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN
Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 2005 Dec 01; 24(54):8003-11.
Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.
Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J. 2007 Nov 01; 407(3):321-9.
Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals.
Bonilla M, Denicola A, Novoselov SV, Turanov AA, Protasio A, Izmendi D, Gladyshev VN, Salinas G
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem. 2008 Jun 27; 283(26):17898-907.
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.
Papp LV, Wang J, Kennedy D, Boucher D, Zhang Y, Gladyshev VN, Singh RN, Khanna KK
Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res. 2008 Dec; 36(22):7192-206.
Functional characterization of alternatively spliced human SECISBP2 transcript variants.
Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function. Chem Rev. 2009 Oct; 109(10):4828-61.
Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function.
Eukaryotic selenoproteins and selenoproteomes. Biochim Biophys Acta. 2009 Nov; 1790(11):1424-8.
Eukaryotic selenoproteins and selenoproteomes.
dbTEU: a protein database of trace element utilization. Bioinformatics. 2010 Mar 01; 26(5):700-2.
dbTEU: a protein database of trace element utilization.
Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal. 2011 Jul 01; 15(1):135-46.
Redox biology: computational approaches to the investigation of functional cysteine residues.
Kasaikina MV, Lobanov AV, Malinouski MY, Lee BC, Seravalli J, Fomenko DE, Turanov AA, Finney L, Vogt S, Park TJ, Miller RA, Hatfield DL, Gladyshev VN
Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression. J Biol Chem. 2011 May 13; 286(19):17005-14.
Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression.
Uluisik I, Kaya A, Fomenko DE, Karakaya HC, Carlson BA, Gladyshev VN, Koc A
Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One. 2011; 6(11):e27772.
Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.
Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko DE, Gladyshev VN, Hatfield DL, Davis CD
Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. PLoS One. 2012; 7(12):e50574.
Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.
O'Connell AE, Gerashchenko MV, O'Donohue MF, Rosen SM, Huntzinger E, Gleeson D, Galli A, Ryder E, Cao S, Murphy Q, Kazerounian S, Morton SU, Schmitz-Abe K, Gladyshev VN, Gleizes PE, Séraphin B, Agrawal PB
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PLoS Genet. 2019 02; 15(2):e1007917.
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.
Mariotti M, Salinas G, Gabaldón T, Gladyshev VN
Utilization of selenocysteine in early-branching fungal phyla. Nat Microbiol. 2019 05; 4(5):759-765.
Utilization of selenocysteine in early-branching fungal phyla.
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metab. 2019 04 02; 29(4):871-885.e5.
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Egorov AA, Sakharova EA, Anisimova AS, Dmitriev SE, Gladyshev VN, Kulakovskiy IV
svist4get: a simple visualization tool for genomic tracks from sequencing experiments. BMC Bioinformatics. 2019 Mar 06; 20(1):113.
svist4get: a simple visualization tool for genomic tracks from sequencing experiments.
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 04 18; 177(3):622-638.e22.
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Harvard T.H. Chan School of Public Health
Samuel A. Levine Professor of Medicine; Hersey Distinguished Professor of the Theory and Practice of Physic
Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019 05 28; 27(9):2785-2797.e3.
Selenium Deficiency Is Associated with Pro-longevity Mechanisms.
James Stillman Professor of Developmental Biology
Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metab. 2019 09 03; 30(3):573-593.e8.
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
Galkin F, Zhang B, Dmitriev SE, Gladyshev VN
Reversibility of irreversible aging. Ageing Res Rev. 2019 01; 49:104-114.
Baclaocos J, Santesmasses D, Mariotti M, Bierla K, Vetick MB, Lynch S, McAllen R, Mackrill JJ, Loughran G, Guigó R, Szpunar J, Copeland PR, Gladyshev VN, Atkins JF
Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs. J Mol Biol. 2019 11 08; 431(22):4381-4407.
Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.
Santesmasses D, Mariotti M, Gladyshev VN
Tolerance to Selenoprotein Loss Differs between Human and Mouse. Mol Biol Evol. 2020 02 01; 37(2):341-354.
Tolerance to Selenoprotein Loss Differs between Human and Mouse.
Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Sci Signal. 2018 07 10; 11(538).
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M
Latest advances in aging research and drug discovery. Aging (Albany NY). 2019 11 21; 11(22):9971-9981.
Latest advances in aging research and drug discovery.
Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, Christensen BC, Gladyshev VN, Heijmans BT, Horvath S, Ideker T, Issa JJ, Kelsey KT, Marioni RE, Reik W, Relton CL, Schalkwyk LC, Teschendorff AE, Wagner W, Zhang K, Rakyan VK
DNA methylation aging clocks: challenges and recommendations. Genome Biol. 2019 11 25; 20(1):249.
DNA methylation aging clocks: challenges and recommendations.
Smekalova EM, Gerashchenko MV, O'Connor PBF, Whittaker CA, Kauffman KJ, Fefilova AS, Zatsepin TS, Bogorad RL, Baranov PV, Langer R, Gladyshev VN, Anderson DG, Koteliansky V
In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation. Mol Ther Nucleic Acids. 2020 Mar 06; 19:252-266.
In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.
Unbiased identification of interventions that extend lifespan
Kinzina ED, Podolskiy DI, Dmitriev SE, Gladyshev VN
Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality. Cell Rep. 2019 12 24; 29(13):4276-4284.e3.
Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.
Kaya A, Mariotti M, Tyshkovskiy A, Zhou X, Hulke ML, Ma S, Gerashchenko MV, Koren A, Gladyshev VN
Molecular signatures of aneuploidy-driven adaptive evolution. Nat Commun. 2020 01 30; 11(1):588.
Molecular signatures of aneuploidy-driven adaptive evolution.
Bioinformatics of Selenoproteins. Antioxid Redox Signal. 2020 09 01; 33(7):525-536.
Fernando R, Wardelmann K, Deubel S, Kehm R, Jung T, Mariotti M, Vasilaki A, Gladyshev VN, Kleinridders A, Grune T, Castro JP
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol. 2020 05; 32:101507.
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
Shindyapina AV, Zenin AA, Tarkhov AE, Santesmasses D, Fedichev PO, Gladyshev VN
Germline burden of rare damaging variants negatively affects human healthspan and lifespan. Elife. 2020 04 07; 9.
Germline burden of rare damaging variants negatively affects human healthspan and lifespan.
Zhang B, Podolskiy DI, Mariotti M, Seravalli J, Gladyshev VN
Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks. Aging Cell. 2020 05; 19(5):e13119.
Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks.
Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10789-10796.
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK
High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020 Jul; 46(4):653-664.
High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.
Liberman N, O'Brown ZK, Earl AS, Boulias K, Gerashchenko MV, Wang SY, Fritsche C, Fady PE, Dong A, Gladyshev VN, Greer EL
N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Sci Adv. 2020 04; 6(17):eaaz4370.
N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.
Sánchez-López C, Labadie N, Lombardo VA, Biglione FA, Manta B, Jacob RS, Gladyshev VN, Abdelilah-Seyfried S, Selenko P, Binolfi A
Chemistry (Weinheim an der Bergstrasse, Germany)
An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo*. Chemistry. 2020 Nov 20; 26(65):14838-14843.
An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo*.
Lashkevich KA, Shlyk VI, Kushchenko AS, Gladyshev VN, Alkalaeva EZ, Dmitriev SE
CTELS: A Cell-Free System for the Analysis of Translation Termination Rate. Biomolecules. 2020 06 16; 10(6).
CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.
Anisimova AS, Meerson MB, Gerashchenko MV, Kulakovskiy IV, Dmitriev SE, Gladyshev VN
Multifaceted deregulation of gene expression and protein synthesis with age. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15581-15590.
Multifaceted deregulation of gene expression and protein synthesis with age.
Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 2020 10; 191:111316.
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
Organ-Specific Biological Age and Its Applications
Role of rare damaging mutations in aging
Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 07 28; 32(4):107949.
Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.
Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678.
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA
The conundrum of human immune system "senescence". Mech Ageing Dev. 2020 12; 192:111357.
The conundrum of human immune system "senescence".
Gerashchenko MV, Nesterchuk MV, Smekalova EM, Paulo JA, Kowalski PS, Akulich KA, Bogorad R, Dmitriev SE, Gygi S, Zatsepin T, Anderson DG, Gladyshev VN, Koteliansky VE
Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Sci Rep. 2020 09 23; 10(1):15473.
Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
Santesmasses D, Castro JP, Zenin AA, Shindyapina AV, Gerashchenko MV, Zhang B, Kerepesi C, Yim SH, Fedichev PO, Gladyshev VN
COVID-19 is an emergent disease of aging. Aging Cell. 2020 10; 19(10):e13230.
COVID-19 is an emergent disease of aging.
The Ground Zero of Organismal Life and Aging. Trends Mol Med. 2021 01; 27(1):11-19.
The Ground Zero of Organismal Life and Aging.
Gerashchenko MV, Peterfi Z, Yim SH, Gladyshev VN
Translation elongation rate varies among organs and decreases with age. Nucleic Acids Res. 2021 01 25; 49(2):e9.
Translation elongation rate varies among organs and decreases with age.
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA
Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129.
Reprogramming to recover youthful epigenetic information and restore vision.
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 12 30; 12(24):24484-24503.
ARDD 2020: from aging mechanisms to interventions.
Choi DW, Roh YJ, Kim S, Lee HM, Kim M, Shin D, Park JH, Cho Y, Park HH, Ok YS, Kang D, Kim JH, Tarrago L, Danial NN, Gladyshev VN, Min PK, Lee BC
Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues. Biosens Bioelectron. 2021 Apr 15; 178:113031.
Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.
Augereau A, Mariotti M, Pousse M, Filipponi D, Libert F, Beck B, Gorbunova V, Gilson E, Gladyshev VN
Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci Adv. 2021 02; 7(8).
Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.
Ristow M, Lee CH, De Bock K, Gladyshev VN, Hotamisligil GS, Manning BD
Methods in molecular biology (Clifton, N.J.)
Measuring Organ-Specific Translation Elongation Rate in Mice. Methods Mol Biol. 2021; 2252:189-200.
Measuring Organ-Specific Translation Elongation Rate in Mice.
Vorontsov IE, Egorov AA, Anisimova AS, Eliseeva IA, Makeev VJ, Gladyshev VN, Dmitriev SE, Kulakovskiy IV
Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates. Methods Mol Biol. 2021; 2252:269-294.
Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates.
Jin L, Tang Q, Hu S, Chen Z, Zhou X, Zeng B, Wang Y, He M, Li Y, Gui L, Shen L, Long K, Ma J, Wang X, Chen Z, Jiang Y, Tang G, Zhu L, Liu F, Zhang B, Huang Z, Li G, Li D, Gladyshev VN, Yin J, Gu Y, Li X, Li M
A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription. Nat Commun. 2021 06 17; 12(1):3715.
A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription.
Kerepesi C, Zhang B, Lee SG, Trapp A, Gladyshev VN
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci Adv. 2021 Jun; 7(26).
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
Tian R, Han K, Geng Y, Yang C, Guo H, Shi C, Xu S, Yang G, Zhou X, Gladyshev VN, Liu X, Chopin LK, Fisher DO, Baker AM, Leiner NO, Fan G, Seim I
A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis). Genome Biol Evol. 2021 08 03; 13(8).
A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis).
Khera N, Santesmasses D, Kerepesi C, Gladyshev VN
COVID-19 mortality rate in children is U-shaped. Aging (Albany NY). 2021 08 18; 13(16):19954-19962.
COVID-19 mortality rate in children is U-shaped.
Tian R, Han K, Geng Y, Yang C, Shi C, Thomas PB, Pearce C, Moffatt K, Ma S, Xu S, Yang G, Zhou X, Gladyshev VN, Liu X, Fisher DO, Chopin LK, Leiner NO, Baker AM, Fan G, Seim I
A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating. Mol Ecol Resour. 2022 Feb; 22(2):740-754.
A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating.
Applying deductive reasoning and the principles of particle physics to aging research. Aging (Albany NY). 2021 09 20; 13(18):22611-22622.
Applying deductive reasoning and the principles of particle physics to aging research.
Egorov AA, Alexandrov AI, Urakov VN, Makeeva DS, Edakin RO, Kushchenko AS, Gladyshev VN, Kulakovskiy IV, Dmitriev SE
A standard knockout procedure alters expression of adjacent loci at the translational level. Nucleic Acids Res. 2021 11 08; 49(19):11134-11144.
A standard knockout procedure alters expression of adjacent loci at the translational level.
Emmrich S, Tolibzoda Zakusilo F, Trapp A, Zhou X, Zhang Q, Irving EM, Drage MG, Zhang Z, Gladyshev VN, Seluanov A, Gorbunova V
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats. Aging Cell. 2021 10; 20(10):e13477.
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Sendai virus persistence questions the transient naive reprogramming method for iPSC generation. bioRxiv. 2024 Mar 12.
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Understanding Interorgan Communication Through Heterochronic Organ Transplantation
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Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation. iScience. 2024 Jun 21; 27(6):109868.
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A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research. bioRxiv. 2024 May 13.
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A single cell atlas of the mouse seminal vesicle. bioRxiv. 2024 Apr 11.
A single cell atlas of the mouse seminal vesicle.
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AgeMeta: Quantitative Gene Expression Database of Mammalian Aging. Biochemistry (Mosc). 2024 Feb; 89(2):313-321.
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The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life. bioRxiv. 2024 May 15.
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Epigenetic predictors of species maximum life span and other life-history traits in mammals. Sci Adv. 2024 06 07; 10(23):eadm7273.
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The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life. Res Sq. 2024 Jun 21.
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PRC2-AgeIndex as a universal biomarker of aging and rejuvenation. Nat Commun. 2024 Jul 16; 15(1):5956.
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Age-associated clonal B cells drive B cell lymphoma in mice. Nat Aging. 2024 Oct; 4(10):1403-1417.
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Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance. PLoS Biol. 2024 Aug; 22(8):e3002778.
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Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis. Carcinogenesis. 2013 May; 34(5):1089-95.
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MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013 Aug 08; 51(3):397-404.
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The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens. ISME J. 2013 Jul; 7(7):1333-43.
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Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. PLoS One. 2013; 8(6):e65637.
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Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2013 Oct 20; 19(12):1362-72.
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SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.
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How to measure biological aging in humans. Nat Med. 2025 Apr; 31(4):1057.
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Invigorating discovery and clinical translation of aging biomarkers. Nat Aging. 2025 Apr; 5(4):539-543.
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A single cell atlas of the mouse seminal vesicle. G3 (Bethesda). 2025 05 08; 15(5).
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The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age. Aging Cell. 2025 Jun; 24(6):e70026.
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The free radical theory of aging is dead. Long live the damage theory! Antioxid Redox Signal. 2014 Feb 01; 20(4):727-31.
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An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.
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Biomarkers of Aging-NIA Joint Symposium 2024: New Insights Into Aging Biomarkers. Aging Cell. 2025 Jul; 24(7):e70124.
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An unbiased comparison of 14 epigenetic clocks in relation to 10-year onset of 174 disease outcomes in 18,859 individuals.
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A unified framework for systematic curation and evaluation of aging biomarkers. Nat Aging. 2025 Nov; 5(11):2323-2339.
A unified framework for systematic curation and evaluation of aging biomarkers.
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Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife. 2014 Apr 29; 3:e02077.
Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.
Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N
The first international mini-symposium on methionine restriction and lifespan. Front Genet. 2014; 5:122.
The first international mini-symposium on methionine restriction and lifespan.
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Selenoprotein S is involved in maintenance and transport of multiprotein complexes. Biochem J. 2014 Sep 15; 462(3):555-65.
Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
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Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage. RNA. 2014 Jul; 20(7):1023-34.
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Grossman AR, Croft M, Gladyshev VN, Merchant SS, Posewitz MC, Prochnik S, Spalding MH
Novel metabolism in Chlamydomonas through the lens of genomics. Curr Opin Plant Biol. 2007 Apr; 10(2):190-8.
Novel metabolism in Chlamydomonas through the lens of genomics.
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Network-driven discovery of repurposable drugs targeting hallmarks of aging. ArXiv. 2025 Sep 03.
Network-driven discovery of repurposable drugs targeting hallmarks of aging.
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Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision. bioRxiv. 2025 Sep 01.
Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
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In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation. bioRxiv. 2025 Jun 27.
In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation.
Murach KA, Dungan CM, Chambers TL, Horvath S, Nandakumar J, Gladyshev VN, Pletcher SD, Dai X, Guo L
Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. Aging Cell. 2025 Nov; 24(11):e70236.
Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.
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Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale. Nature. 2025 Dec; 648(8094):E14.
Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale.
Dowrey TW, Cranston SF, Skvir NJ, Lok Y, Bock P, Kharitonova EK, MacDonald E, Zeldich E, Gabel CV, Tyshkovskiy A, Monti S, Gladyshev VN, Sebastiani P, Perls TT, Andersen S, Murphy GJ
IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures. bioRxiv. 2025 Oct 11.
IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures.
Chen Q, Dwaraka VB, Carreras-Gallo N, Armstrong JF, Sehgal R, Argentieri MA, Richmond A, Aparicio A, Mendez K, Chen Y, Begum S, Kachroo P, Prince N, Guo T, Went H, Mendez T, Lin A, Turner L, Moqri M, Chu SH, Kelly RS, Weiss ST, Rattray NJW, Gladyshev VN, Karlson E, Wheelock CE, Mathé EA, Dahlin A, McGeachie MJ, Marioni RE, Higgins-Chen AT, Smith R, Lasky-Su J
OMICmAge quantifies biological age by integrating multi-omics with electronic medical records. Nat Aging. 2026 Mar; 6(3):722-737.
OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.
Zhang Z, Simon M, Liang Y, Tyshkovskiy A, Kaplan M, Paige V, Biashad SA, Gladyshev V, Seluanov A, Gorbunova V
Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations. bioRxiv. 2026 Feb 06.
Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations.
Furman D, Auwerx J, Bulteau AL, Church G, Couturaud V, Crabbe L, Davies KJA, Decottignies A, Gladyshev VN, Kennedy BK, Neretti N, Nizard C, Pays K, Robinton D, Sebastiano V, Watson REB, Wang MC, Woltjen K
Skin health and biological aging. Nat Aging. 2025 Jul; 5(7):1195-1206.
Rothi MH, Sarkar GC, Haddad JA, Mitchell W, Ying K, Pohl N, Sotomayor-Mena RG, Natale J, Dellacona S, Gladyshev VN, Greer EL
The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life. Nat Commun. 2025 Jul 28; 16(1):6944.
The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life.
Nayak G, Richard EM, Lee BC, Riordan GP, Belyantseva IA, Manta B, Friedman TB, Gladyshev VN, Riazuddin S
MSRB3 antioxidant activity is necessary for inner ear cuticular plate structure and hair bundle integrity. Dis Model Mech. 2025 Aug 01; 18(8).
MSRB3 antioxidant activity is necessary for inner ear cuticular plate structure and hair bundle integrity.
Kim KI, Bello NA, Galea LAM, Gladyshev VN, Jasienska G, McKinley KL, Miller EC, Parks WT, Pollack AZ, Prewit EB, Rich-Edwards J, Ryan CP, Slaughter-Acey J, Stanhewicz AE, Warrington JP, Suh Y
A National Institute on Aging workshop on the long-term effects of pregnancy on aging. Nat Aging. 2025 Dec; 5(12):2372-2375.
A National Institute on Aging workshop on the long-term effects of pregnancy on aging.
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Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health. JCI Insight. 2025 Dec 22; 10(24).
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.
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Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model.
Mitchell W, de Magalhães CG, Tyshkovskiy A, Uchida Y, Goeminne LJE, Ichimura T, Ng EL, Moldakozhayev A, Bonventre JV, Gladyshev VN
In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation. Aging Cell. 2026 Feb; 25(2):e70390.
In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation.
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The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Apr 28; 4(7):1183-91.
The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast.
Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE
Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62.
Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.
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Selenoproteins: molecular pathways and physiological roles.
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Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80.
Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.
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Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014 Sep 11; 8(5):1354-64.
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
Kaya A, Lobanov AV, Gerashchenko MV, Koren A, Fomenko DE, Koc A, Gladyshev VN
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae. Genetics. 2014 Nov; 198(3):905-17.
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.
Translation inhibitors cause abnormalities in ribosome profiling experiments. Nucleic Acids Res. 2014; 42(17):e134.
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The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal. Aging (Albany NY). 2014 Oct; 6(10):879-99.
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.
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Gene expression defines natural changes in mammalian lifespan. Aging Cell. 2015 Jun; 14(3):352-65.
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Bang J, Jang M, Huh JH, Na JW, Shim M, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ
Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway. Biochem Biophys Res Commun. 2015 Jan 24; 456(4):884-90.
Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.
Tsuji PA, Carlson BA, Yoo MH, Naranjo-Suarez S, Xu XM, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways. PLoS One. 2015; 10(4):e0124487.
The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
Nakao LS, Everley RA, Marino SM, Lo SM, de Souza LE, Gygi SP, Gladyshev VN
Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins. J Biol Chem. 2015 Feb 27; 290(9):5685-95.
Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae. Aging Cell. 2015 Jun; 14(3):366-71.
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.
MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 2015 Apr; 14(2):288-91.
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.
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Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nat Chem Biol. 2015 May; 11(5):332-8.
Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors.
Cornelis MC, Fornage M, Foy M, Xun P, Gladyshev VN, Morris S, Chasman DI, Hu FB, Rimm EB, Kraft P, Jordan JM, Mozaffarian D, He K
Genome-wide association study of selenium concentrations. Hum Mol Genet. 2015 Mar 01; 24(5):1469-77.
Genome-wide association study of selenium concentrations.
Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J
Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet. 2014 Aug; 15(8):531-40.
Comparative genetics of longevity and cancer: insights from long-lived rodents.
Kim MJ, Lee BC, Hwang KY, Gladyshev VN, Kim HY
Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine. Biochem Biophys Res Commun. 2015 Jun 12; 461(4):648-52.
Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine.
Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR
Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015 Jan 15; 160(1-2):132-44.
Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A
INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1053-8.
INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.
Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ
Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells. Mol Cells. 2015 May; 38(5):457-65.
Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.
Gould NS, Evans P, Martínez-Acedo P, Marino SM, Gladyshev VN, Carroll KS, Ischiropoulos H
Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. Chem Biol. 2015 Jul 23; 22(7):965-75.
Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.
Ma S, Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R, Lewis KN, Park TJ, Miller RA, Clish CB, Gladyshev VN
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab. 2015 Aug 04; 22(2):332-43.
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.
Mariotti M, Santesmasses D, Capella-Gutierrez S, Mateo A, Arnan C, Johnson R, D'Aniello S, Yim SH, Gladyshev VN, Serras F, Corominas M, Gabaldón T, Guigó R
Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization. Genome Res. 2015 Sep; 25(9):1256-67.
Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.
Kaya A, Gerashchenko MV, Seim I, Labarre J, Toledano MB, Gladyshev VN
Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):10685-90.
Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.
Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1. Antioxid Redox Signal. 2015 Oct 01; 23(10):814-22.
Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.
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Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine. PLoS One. 2015; 10(10):e0140353.
Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.
Selenium and Methionine Sulfoxide Reduction. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S8-9.
Selenium and Methionine Sulfoxide Reduction.
Convergent evolution of marine mammals is associated with distinct substitutions in common genes. Sci Rep. 2015 Nov 09; 5:16550.
Convergent evolution of marine mammals is associated with distinct substitutions in common genes.
Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN
Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep. 2015 Nov 17; 13(7):1319-1326.
Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.
Tobe R, Carlson BA, Tsuji PA, Lee BJ, Gladyshev VN, Hatfield DL
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers (Basel). 2015 Nov 10; 7(4):2262-76.
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J
DNA repair in species with extreme lifespan differences. Aging (Albany NY). 2015 Dec; 7(12):1171-84.
DNA repair in species with extreme lifespan differences.
Methionine restriction and life-span control. Ann N Y Acad Sci. 2016 Jan; 1363:116-24.
Methionine restriction and life-span control.
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Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY). 2016 05; 8(5):841-7.
Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.
Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell. 2016 08; 15(4):594-602.
Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.
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Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 07 15; 473(14):2141-54.
Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.
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Analysis of cancer genomes reveals basic features of human aging and its role in cancer development. Nat Commun. 2016 08 12; 7:12157.
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.
Mariotti M, Lobanov AV, Manta B, Santesmasses D, Bofill A, Guigó R, Gabaldón T, Gladyshev VN
Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Mol Biol Evol. 2016 09; 33(9):2441-53.
Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.
Functions of thioredoxin reductases and their targets
Selenoproteins as targets for cancer prevention
Redox mechanism of cancer prevention by selenium
Identity and Function of Selenoprotein Genes
Methionine sulfoxide reduction, selenium and aging
Arterial Dysfunction: Basic and Clinical Mechanisms
Functions of Mammalian Thioredoxin Reductases
Function of thioredoxin glutathione reductase
2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference
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Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71.
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
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Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Mol Biol Evol. 2016 10; 33(10):2670-81.
Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys.
Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide. Methods. 2016 10 15; 109:149-157.
Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.
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Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths. BMC Genomics. 2010 Apr 13; 11:237.
Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths.
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Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates. NPJ Aging Mech Dis. 2015; 1.
Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.
Comparative Genomics and Evolution of Molybdenum Utilization. Coord Chem Rev. 2011 May; 255(9-10):1206-1217.
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Intrinsic Versus Extrinsic Cancer Risk Factors and Aging. Trends Mol Med. 2016 Oct; 22(10):833-834.
Intrinsic Versus Extrinsic Cancer Risk Factors and Aging.
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Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biol. 2016 10; 9:22-31.
Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
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Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Mol Biol Evol. 2016 11; 33(11):2885-2889.
Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum.
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Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040.
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Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.
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Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals.
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Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One. 2008 Jan 02; 3(1):e1378.
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Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project.
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Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics. 2009 Feb 10; 10:78.
Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization.
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Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxid Redox Signal. 2010 Apr 01; 12(7):819-27.
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Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif.
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Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.
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Selenoproteins mediate T cell immunity through an antioxidant mechanism.
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Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
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Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.
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Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis.
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Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.
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A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.
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Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
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Recharging oxidative protein repair: catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates.
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Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.
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In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait. BMC Genomics. 2008 May 29; 9:251.
In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait.
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Recode-2: new design, new search tools, and many more genes. Nucleic Acids Res. 2010 Jan; 38(Database issue):D69-74.
Recode-2: new design, new search tools, and many more genes.
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Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol. 2008; 9(3):R62.
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Dual functions of codons in the genetic code.
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Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.
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Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010 Aug 18; 5(8):e12249.
Selenoproteins are essential for proper keratinocyte function and skin development.
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Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.
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Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
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Genome sequencing reveals insights into physiology and longevity of the naked mole rat.
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Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis. 2012 Sep; 33(9):1806-13.
Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.
Hu YJ, Korotkov KV, Mehta R, Hatfield DL, Rotimi CN, Luke A, Prewitt TE, Cooper RS, Stock W, Vokes EE, Dolan ME, Gladyshev VN, Diamond AM
Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Res. 2001 Mar 01; 61(5):2307-10.
Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.
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Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.
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Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep. 2004 Jan; 5(1):71-7.
Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.
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Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res. 2006; 34(14):4012-24.
Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.
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Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. Biochemistry (Mosc). 1997 Dec; 62(12):1439-43.
Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme.