Gladyshev, Vadim
eCommons Login: VG36
first name: Vadim
last name: Gladyshev
coauthor of: Moqri, Mahdi
coauthor of: Poganik, Jesse
coauthor of: Goeminne, Ludger
coauthor of: Gygi, Steven
coauthor of: Jacques, Erik
full name: Vadim Gladyshev, Ph.D.
has faculty rank: Full Professor
has network: selected publications
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latitude: 42.33837200000000
longitude: -71.10326900000000
Person ID: 4185
person in primary position: Professor of Medicine
physical neighbor: Bulyk, Martha
physical neighbor: Green, Robert
physical neighbor: Kang, Hyuck Joon
physical neighbor: Kucherlapati, Melanie
physical neighbor: Li, Zhe
similar to: Perrimon, Norbert
similar to: Gygi, Steven
similar to: Loscalzo, Joseph
similar to: Church, George
similar to: Baccarelli, Andrea
type: Agent
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selected publications: Authorship 1834397
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selected publications: Authorship 1679028

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Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality.
PubMed Identifier: 11389138
author list: Martin-Romero FJ, Kryukov GV, Lobanov AV, Carlson BA, Lee BJ, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. J Biol Chem. 2001 Aug 10; 276(32):29798-804.
journal title abbreviation: J Biol Chem
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1049751
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.
PubMed Identifier: 29432174
author list: Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1801-1806.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2018-02-05T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.
PubMed Identifier: 11278576
author list: Korotkov KV, Kumaraswamy E, Zhou Y, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. J Biol Chem. 2001 May 04; 276(18):15330-6.
journal title abbreviation: J Biol Chem
publication date: 2001-02-07T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.
PubMed Identifier: 12915322
author list: Thisse C, Degrave A, Kryukov GV, Gladyshev VN, Obrecht-Pflumio S, Krol A, Thisse B, Lescure A
published in: Gene expression patterns : GEP
information resource reference: Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003 Aug; 3(4):525-32.
journal title abbreviation: Gene Expr Patterns
publication date: 2003-08-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases.
PubMed Identifier: 14699060
author list: Kim HY, Gladyshev VN
published in: Molecular biology of the cell
information resource reference: Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell. 2004 Mar; 15(3):1055-64.
journal title abbreviation: Mol Biol Cell
publication date: 2003-12-29T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase.
PubMed Identifier: 15249228
author list: Kim HY, Gladyshev VN
published in: Biochemical and biophysical research communications
information resource reference: Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem Biophys Res Commun. 2004 Aug 06; 320(4):1277-83.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2004-08-06T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?
PubMed Identifier: 15843685
author list: Taskov K, Chapple C, Kryukov GV, Castellano S, Lobanov AV, Korotkov KV, Guigó R, Gladyshev VN
published in: Nucleic acids research
information resource reference: Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? Nucleic Acids Res. 2005; 33(7):2227-38.
journal title abbreviation: Nucleic Acids Res
publication date: 2005-04-20T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1055148
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.
PubMed Identifier: 29575528
author list: Sziráki A, Tyshkovskiy A, Gladyshev VN
published in: Aging cell
information resource reference: Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell. 2018 06; 17(3):e12738.
journal title abbreviation: Aging Cell
publication date: 2018-03-25T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri.
PubMed Identifier: 8555176
author list: Gladyshev VN, Khangulov SV, Stadtman TC
published in: Biochemistry
information resource reference: Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri. Biochemistry. 1996 Jan 09; 35(1):212-23.
journal title abbreviation: Biochemistry
publication date: 1996-01-09T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1056133
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

Authorship 1055994
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Mechanisms of cancer resistance in long-lived mammals.

Mechanisms of cancer resistance in long-lived mammals.
PubMed Identifier: 29622806
author list: Seluanov A, Gladyshev VN, Vijg J, Gorbunova V
published in: Nature reviews. Cancer
information resource reference: Mechanisms of cancer resistance in long-lived mammals. Nat Rev Cancer. 2018 07; 18(7):433-441.
journal title abbreviation: Nat Rev Cancer
publication date: 2018-07-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.
PubMed Identifier: 29608729
author list: Zhou X, Sun D, Guang X, Ma S, Fang X, Mariotti M, Nielsen R, Gladyshev VN, Yang G
published in: Genome biology and evolution
information resource reference: Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans. Genome Biol Evol. 2018 03 01; 10(3):967-975.
journal title abbreviation: Genome Biol Evol
publication date: 2018-03-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Systems level understanding of selenoprotein biosynthesis
end date: 2024-03-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2018-04-01
type: Grant
sponsor award id: R01DK117149

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Systems level understanding of selenoprotein biosynthesis

Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.
PubMed Identifier: 29636446
author list: Zhou X, Guang X, Sun D, Xu S, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R, Fang X, Yang G
published in: Nature communications
information resource reference: Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater. Nat Commun. 2018 04 10; 9(1):1276.
journal title abbreviation: Nat Commun
publication date: 2018-04-10T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 108095
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA.

Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS.
PubMed Identifier: 12473832
author list: Xu XM, Carlson BA, Grimm TA, Kutza J, Berry MJ, Arreola R, Fields KH, Shanmugam I, Jeang KT, Oroszlan S, Combs GF, Marx PA, Gladyshev VN, Clouse KA, Hatfield DL
published in: Journal of acquired immune deficiency syndromes (1999)
information resource reference: Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS. J Acquir Immune Defic Syndr. 2002 Dec 15; 31(5):453-63.
journal title abbreviation: J Acquir Immune Defic Syndr
publication date: 2002-12-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues.
PubMed Identifier: 19424433
author list: Marino SM, Gladyshev VN
published in: PLoS computational biology
information resource reference: A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues. PLoS Comput Biol. 2009 May; 5(5):e1000383.
journal title abbreviation: PLoS Comput Biol
publication date: 2009-05-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces.
PubMed Identifier: 20950627
author list: Marino SM, Gladyshev VN
published in: Journal of molecular biology
information resource reference: Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. J Mol Biol. 2010 Dec 17; 404(5):902-16.
journal title abbreviation: J Mol Biol
publication date: 2010-10-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1057283
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

Authorship 1059627
type: Authorship
author rank in publication: 18
linked author: Gladyshev, Vadim
linked information resource: Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.
PubMed Identifier: 29671950
author list: Ma S, Avanesov AS, Porter E, Lee BC, Mariotti M, Zemskaya N, Guigo R, Moskalev AA, Gladyshev VN
published in: Aging cell
information resource reference: Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Aging Cell. 2018 08; 17(4):e12740.
journal title abbreviation: Aging Cell
publication date: 2018-04-19T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of trace element-containing proteins in genomic databases.
PubMed Identifier: 15189132
author list: Gladyshev VN, Kryukov GV, Fomenko DE, Hatfield DL
published in: Annual review of nutrition
information resource reference: Identification of trace element-containing proteins in genomic databases. Annu Rev Nutr. 2004; 24:579-96.
journal title abbreviation: Annu Rev Nutr
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.
PubMed Identifier: 15611090
author list: Carlson BA, Xu XM, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem. 2005 Feb 18; 280(7):5542-8.
journal title abbreviation: J Biol Chem
publication date: 2004-12-17T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
PubMed Identifier: 18973473
author list: Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, Hatfield DL
published in: The Biochemical journal
information resource reference: The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Biochem J. 2009 Feb 15; 418(1):61-71.
journal title abbreviation: Biochem J
publication date: 2009-02-15T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus.
PubMed Identifier: 19636847
author list: Sal LS, Aachmann FL, Kim HY, Gladyshev VN, Dikiy A
published in: Biomolecular NMR assignments
information resource reference: NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus. Biomol NMR Assign. 2007 Jul; 1(1):131-3.
journal title abbreviation: Biomol NMR Assign
publication date: 2007-07-31T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se.
PubMed Identifier: 19887375
author list: Zhang Y, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se. J Biol Chem. 2010 Jan 29; 285(5):3393-405.
journal title abbreviation: J Biol Chem
publication date: 2009-11-02T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.
PubMed Identifier: 19863805
author list: Carlson BA, Yoo MH, Sano Y, Sengupta A, Kim JY, Irons R, Gladyshev VN, Hatfield DL, Park JM
published in: BMC immunology
information resource reference: Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol. 2009 Oct 28; 10:57.
journal title abbreviation: BMC Immunol
publication date: 2009-10-28T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Hydrogen peroxide probes directed to different cellular compartments.
PubMed Identifier: 21283738
author list: Malinouski M, Zhou Y, Belousov VV, Hatfield DL, Gladyshev VN
published in: PloS one
information resource reference: Hydrogen peroxide probes directed to different cellular compartments. PLoS One. 2011 Jan 21; 6(1):e14564.
journal title abbreviation: PLoS One
publication date: 2011-01-21T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA.
PubMed Identifier: 21624347
author list: Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL
published in: Biochemical and biophysical research communications
information resource reference: Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):814-9.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2011-05-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1062764
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation.

Authorship 1062971
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.
PubMed Identifier: 29719252
author list: Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN
published in: Cell reports
information resource reference: Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 2018 05 01; 23(5):1387-1398.
journal title abbreviation: Cell Rep
publication date: 2018-05-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation.
PubMed Identifier: 29715549
author list: Na J, Jung J, Bang J, Lu Q, Carlson BA, Guo X, Gladyshev VN, Kim J, Hatfield DL, Lee BJ
published in: Free radical biology & medicine
information resource reference: Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation. Free Radic Biol Med. 2018 11 01; 127:190-197.
journal title abbreviation: Free Radic Biol Med
publication date: 2018-04-30T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells.
PubMed Identifier: 17470795
author list: Novoselov SV, Lobanov AV, Hua D, Kasaikina MV, Hatfield DL, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7857-62.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-04-30T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 103860
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2.

Methionine sulfoxide reduction and the aging process.
PubMed Identifier: 17460202
author list: Koc A, Gladyshev VN
published in: Annals of the New York Academy of Sciences
information resource reference: Methionine sulfoxide reduction and the aging process. Ann N Y Acad Sci. 2007 Apr; 1100:383-6.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2007-04-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life.
PubMed Identifier: 17880704
author list: Lobanov AV, Fomenko DE, Zhang Y, Sengupta A, Hatfield DL, Gladyshev VN
published in: Genome biology
information resource reference: Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life. Genome Biol. 2007; 8(9):R198.
journal title abbreviation: Genome Biol
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Molybdoproteomes and evolution of molybdenum utilization.
PubMed Identifier: 18485362
author list: Zhang Y, Gladyshev VN
published in: Journal of molecular biology
information resource reference: Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol. 2008 Jun 13; 379(4):881-99.
journal title abbreviation: J Mol Biol
publication date: 2008-04-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression.
PubMed Identifier: 19713955
author list: Xu XM, Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL
published in: Nature protocols
information resource reference: Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression. Nat Protoc. 2009; 4(9):1338-48.
journal title abbreviation: Nat Protoc
publication date: 2009-08-27T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1067488
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Selenoproteins in colon cancer.

Authorship 1066741
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Gene expression signatures of human cell and tissue longevity.

Gene expression signatures of human cell and tissue longevity.
PubMed Identifier: 28721269
author list: Seim I, Ma S, Gladyshev VN
published in: NPJ aging and mechanisms of disease
information resource reference: Gene expression signatures of human cell and tissue longevity. NPJ Aging Mech Dis. 2016; 2:16014.
journal title abbreviation: NPJ Aging Mech Dis
publication date: 2016-07-07T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins in colon cancer.
PubMed Identifier: 29793041
author list: Peters KM, Carlson BA, Gladyshev VN, Tsuji PA
published in: Free radical biology & medicine
information resource reference: Selenoproteins in colon cancer. Free Radic Biol Med. 2018 11 01; 127:14-25.
journal title abbreviation: Free Radic Biol Med
publication date: 2018-05-22T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery.
PubMed Identifier: 21115847
author list: Xu XM, Turanov AA, Carlson BA, Yoo MH, Everley RA, Nandakumar R, Sorokina I, Gygi SP, Gladyshev VN, Hatfield DL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21430-4.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-11-29T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis.
PubMed Identifier: 22332041
author list: Turanov AA, Xu XM, Carlson BA, Yoo MH, Gladyshev VN, Hatfield DL
published in: Advances in nutrition (Bethesda, Md.)
information resource reference: Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis. Adv Nutr. 2011 Mar; 2(2):122-8.
journal title abbreviation: Adv Nutr
publication date: 2011-03-10T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Understanding selenoprotein function and regulation through the use of rodent models.
PubMed Identifier: 22440326
author list: Kasaikina MV, Hatfield DL, Gladyshev VN
published in: Biochimica et biophysica acta
information resource reference: Understanding selenoprotein function and regulation through the use of rodent models. Biochim Biophys Acta. 2012 Sep; 1823(9):1633-42.
journal title abbreviation: Biochim Biophys Acta
publication date: 2012-03-13T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.
PubMed Identifier: 14660662
author list: Carlson BA, Novoselov SV, Kumaraswamy E, Lee BJ, Anver MR, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem. 2004 Feb 27; 279(9):8011-7.
journal title abbreviation: J Biol Chem
publication date: 2003-12-04T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomics of trace element dependence in biology.
PubMed Identifier: 21566146
author list: Zhang Y, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Comparative genomics of trace element dependence in biology. J Biol Chem. 2011 Jul 08; 286(27):23623-9.
journal title abbreviation: J Biol Chem
publication date: 2011-05-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
PubMed Identifier: 29899023
author list: Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA
published in: Science translational medicine
information resource reference: NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445).
journal title abbreviation: Sci Transl Med
publication date: 2018-06-13T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.
PubMed Identifier: 17337453
author list: Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem. 2007 Apr 20; 282(16):11960-8.
journal title abbreviation: J Biol Chem
publication date: 2007-03-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.
PubMed Identifier: 17503775
author list: Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, Cerny RL, Ginalski K, Grishin NV, Hatfield DL, Gladyshev VN
published in: Biochemistry
information resource reference: SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007 Jun 12; 46(23):6871-82.
journal title abbreviation: Biochemistry
publication date: 2007-05-16T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.
PubMed Identifier: 10455115
author list: Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 1999 Aug 27; 274(35):24522-30.
journal title abbreviation: J Biol Chem
publication date: 1999-08-27T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.
PubMed Identifier: 17916946
author list: Xu XM, Carlson BA, Zhang Y, Mix H, Kryukov GV, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL
published in: Biological trace element research
information resource reference: New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. Biol Trace Elem Res. 2007 Dec; 119(3):234-41.
journal title abbreviation: Biol Trace Elem Res
publication date: 2007-12-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1073745
type: Authorship
author rank in publication: 24
linked author: Gladyshev, Vadim
linked information resource: NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli.
PubMed Identifier: 8052647
author list: Gladyshev VN, Khangulov SV, Axley MJ, Stadtman TC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7708-11.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-08-02T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme.
PubMed Identifier: 8278371
author list: Gladyshev VN, Khangulov SV, Stadtman TC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):232-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-01-04T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The roles of thiol oxidoreductases in yeast replicative aging.
PubMed Identifier: 20934449
author list: Hacioglu E, Esmer I, Fomenko DE, Gladyshev VN, Koc A
published in: Mechanisms of ageing and development
information resource reference: The roles of thiol oxidoreductases in yeast replicative aging. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):692-9.
journal title abbreviation: Mech Ageing Dev
publication date: 2010-10-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Proteomics: mapping reactive cysteines.
PubMed Identifier: 21245858
author list: Marino SM, Gladyshev VN
published in: Nature chemical biology
information resource reference: Proteomics: mapping reactive cysteines. Nat Chem Biol. 2011 Feb; 7(2):72-3.
journal title abbreviation: Nat Chem Biol
publication date: 2011-02-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.
PubMed Identifier: 22016385
author list: Shchedrina VA, Everley RA, Zhang Y, Gygi SP, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. J Biol Chem. 2011 Dec 16; 286(50):42937-48.
journal title abbreviation: J Biol Chem
publication date: 2011-10-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 103756
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa.
PubMed Identifier: 23460847
author list: Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL
published in: PloS one
information resource reference: Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa. PLoS One. 2013; 8(2):e57389.
journal title abbreviation: PLoS One
publication date: 2013-02-27T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila.
PubMed Identifier: 15721286
author list: Shrimali RK, Lobanov AV, Xu XM, Rao M, Carlson BA, Mahadeo DC, Parent CA, Gladyshev VN, Hatfield DL
published in: Biochemical and biophysical research communications
information resource reference: Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila. Biochem Biophys Res Commun. 2005 Apr 01; 329(1):147-51.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2005-04-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

The microbial selenoproteome of the Sargasso Sea.
PubMed Identifier: 15833124
author list: Zhang Y, Fomenko DE, Gladyshev VN
published in: Genome biology
information resource reference: The microbial selenoproteome of the Sargasso Sea. Genome Biol. 2005; 6(4):R37.
journal title abbreviation: Genome Biol
publication date: 2005-03-29T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family.
PubMed Identifier: 16260744
author list: Castellano S, Lobanov AV, Chapple C, Novoselov SV, Albrecht M, Hua D, Lescure A, Lengauer T, Krol A, Gladyshev VN, Guigó R
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16188-93.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-10-31T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells.
PubMed Identifier: 17065220
author list: Fernando MR, Lechner JM, Löfgren S, Gladyshev VN, Lou MF
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. FASEB J. 2006 Dec; 20(14):2645-7.
journal title abbreviation: FASEB J
publication date: 2006-10-25T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure and catalytic mechanism of eukaryotic selenocysteine synthase.
PubMed Identifier: 18093968
author list: Ganichkin OM, Xu XM, Carlson BA, Mix H, Hatfield DL, Gladyshev VN, Wahl MC
published in: The Journal of biological chemistry
information resource reference: Structure and catalytic mechanism of eukaryotic selenocysteine synthase. J Biol Chem. 2008 Feb 29; 283(9):5849-65.
journal title abbreviation: J Biol Chem
publication date: 2007-12-19T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

A functional link between housekeeping selenoproteins and phase II enzymes.
PubMed Identifier: 18373496
author list: Sengupta A, Carlson BA, Weaver JA, Novoselov SV, Fomenko DE, Gladyshev VN, Hatfield DL
published in: The Biochemical journal
information resource reference: A functional link between housekeeping selenoproteins and phase II enzymes. Biochem J. 2008 Jul 01; 413(1):151-61.
journal title abbreviation: Biochem J
publication date: 2008-07-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology.
PubMed Identifier: 19299660
author list: Hatfield DL, Gladyshev VN
published in: Molecular interventions
information resource reference: The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv. 2009 Feb; 9(1):18-21.
journal title abbreviation: Mol Interv
publication date: 2009-02-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis.
PubMed Identifier: 19379757
author list: Kehr S, Malinouski M, Finney L, Vogt S, Labunskyy VM, Kasaikina MV, Carlson BA, Zhou Y, Hatfield DL, Gladyshev VN
published in: Journal of molecular biology
information resource reference: X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis. J Mol Biol. 2009 Jun 26; 389(5):808-18.
journal title abbreviation: J Mol Biol
publication date: 2009-04-18T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice.
PubMed Identifier: 19769460
author list: Novoselov SV, Kim HY, Hua D, Lee BC, Astle CM, Harrison DE, Friguet B, Moustafa ME, Carlson BA, Hatfield DL, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. Antioxid Redox Signal. 2010 Apr 01; 12(7):829-38.
journal title abbreviation: Antioxid Redox Signal
publication date: 2010-04-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Semisynthesis and characterization of mammalian thioredoxin reductase.
PubMed Identifier: 16618105
author list: Eckenroth B, Harris K, Turanov AA, Gladyshev VN, Raines RT, Hondal RJ
published in: Biochemistry
information resource reference: Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry. 2006 Apr 25; 45(16):5158-70.
journal title abbreviation: Biochemistry
publication date: 2006-04-25T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins.
PubMed Identifier: 17503777
author list: Su D, Berndt C, Fomenko DE, Holmgren A, Gladyshev VN
published in: Biochemistry
information resource reference: A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. Biochemistry. 2007 Jun 12; 46(23):6903-10.
journal title abbreviation: Biochemistry
publication date: 2007-05-16T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A.
PubMed Identifier: 18767149
author list: Kim HY, Zhang Y, Lee BC, Kim JR, Gladyshev VN
published in: Proteins
information resource reference: The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A. Proteins. 2009 Mar; 74(4):1008-17.
journal title abbreviation: Proteins
publication date: 2009-03-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1088312
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts.

A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts.
PubMed Identifier: 30107334
author list: Lee SG, Mikhalchenko AE, Yim SH, Gladyshev VN
published in: Stem cell research
information resource reference: A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts. Stem Cell Res. 2018 08; 31:197-200.
journal title abbreviation: Stem Cell Res
publication date: 2018-06-20T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 114245
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast.

Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
PubMed Identifier: 19409408
author list: Shchedrina VA, Vorbrüggen G, Lee BC, Kim HY, Kabil H, Harshman LG, Gladyshev VN
published in: Mechanisms of ageing and development
information resource reference: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Mech Ageing Dev. 2009 Jul; 130(7):429-43.
journal title abbreviation: Mech Ageing Dev
publication date: 2009-05-03T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.
PubMed Identifier: 21282621
author list: Fomenko DE, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, Rutherford JC, Siu KL, Jin DY, Winge DR, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2729-34.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2011-01-31T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan.
PubMed Identifier: 22915358
author list: Gladyshev VN
published in: BioEssays : news and reviews in molecular, cellular and developmental biology
information resource reference: On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Bioessays. 2012 Nov; 34(11):925-9.
journal title abbreviation: Bioessays
publication date: 2012-08-23T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing.
PubMed Identifier: 20634897
author list: Liang X, Fomenko DE, Hua D, Kaya A, Gladyshev VN
published in: PloS one
information resource reference: Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing. PLoS One. 2010 Jul 09; 5(7):e11497.
journal title abbreviation: PLoS One
publication date: 2010-07-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance.
PubMed Identifier: 21622567
author list: Shchedrina VA, Kabil H, Vorbruggen G, Lee BC, Turanov AA, Hirosawa-Takamori M, Kim HY, Harshman LG, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. J Biol Chem. 2011 Aug 26; 286(34):29449-61.
journal title abbreviation: J Biol Chem
publication date: 2011-05-27T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase.
PubMed Identifier: 18697736
author list: Lee BC, Le DT, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem. 2008 Oct 17; 283(42):28361-9.
journal title abbreviation: J Biol Chem
publication date: 2008-08-12T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins that function in cancer prevention and promotion.
PubMed Identifier: 19272412
author list: Hatfield DL, Yoo MH, Carlson BA, Gladyshev VN
published in: Biochimica et biophysica acta
information resource reference: Selenoproteins that function in cancer prevention and promotion. Biochim Biophys Acta. 2009 Nov; 1790(11):1541-5.
journal title abbreviation: Biochim Biophys Acta
publication date: 2009-03-09T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.
PubMed Identifier: 21854231
author list: Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 01; 16(3):185-92.
journal title abbreviation: Antioxid Redox Signal
publication date: 2011-11-22T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes.
PubMed Identifier: 21902454
author list: Fomenko DE, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes. Antioxid Redox Signal. 2012 Feb 01; 16(3):193-201.
journal title abbreviation: Antioxid Redox Signal
publication date: 2011-11-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.
PubMed Identifier: 21943784
author list: Carlson BA, Yoo MH, Conrad M, Gladyshev VN, Hatfield DL, Park JM
published in: Molecular immunology
information resource reference: Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol. 2011 Oct; 49(1-2):311-6.
journal title abbreviation: Mol Immunol
publication date: 2011-09-22T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.
PubMed Identifier: 21989933
author list: Aachmann FL, Kwak GH, Del Conte R, Kim HY, Gladyshev VN, Dikiy A
published in: Proteins
information resource reference: Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. Proteins. 2011 Nov; 79(11):3123-31.
journal title abbreviation: Proteins
publication date: 2011-08-30T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 131938
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA.

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress.
PubMed Identifier: 23045643
author list: Gerashchenko MV, Lobanov AV, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17394-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2012-10-08T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine in thiol/disulfide-like exchange reactions.
PubMed Identifier: 23121622
author list: Hondal RJ, Marino SM, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Selenocysteine in thiol/disulfide-like exchange reactions. Antioxid Redox Signal. 2013 May 01; 18(13):1675-89.
journal title abbreviation: Antioxid Redox Signal
publication date: 2012-12-16T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases.
PubMed Identifier: 16262444
author list: Kim HY, Gladyshev VN
published in: PLoS biology
information resource reference: Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol. 2005 Dec; 3(12):e375.
journal title abbreviation: PLoS Biol
publication date: 2005-11-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Is there a twenty third amino acid in the genetic code?
PubMed Identifier: 16713651
author list: Lobanov AV, Kryukov GV, Hatfield DL, Gladyshev VN
published in: Trends in genetics : TIG
information resource reference: Is there a twenty third amino acid in the genetic code? Trends Genet. 2006 Jul; 22(7):357-60.
journal title abbreviation: Trends Genet
publication date: 2006-05-19T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism.
PubMed Identifier: 17996733
author list: Sengupta A, Carlson BA, Hoffmann VJ, Gladyshev VN, Hatfield DL
published in: Biochemical and biophysical research communications
information resource reference: Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun. 2008 Jan 18; 365(3):446-52.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2007-11-09T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 123904
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Proteomics: mapping reactive cysteines.

Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
PubMed Identifier: 19049972
author list: Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem. 2009 Feb 13; 284(7):4354-64.
journal title abbreviation: J Biol Chem
publication date: 2008-12-02T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses.
PubMed Identifier: 19650649
author list: Labunskyy VM, Yoo MH, Hatfield DL, Gladyshev VN
published in: Biochemistry
information resource reference: Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry. 2009 Sep 08; 48(35):8458-65.
journal title abbreviation: Biochemistry
publication date: 2009-09-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1108795
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.
PubMed Identifier: 30346102
author list: Ogrodnik M, Salmonowicz H, Gladyshev VN
published in: Aging cell
information resource reference: Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells. Aging Cell. 2019 02; 18(1):e12841.
journal title abbreviation: Aging Cell
publication date: 2018-10-22T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics.
PubMed Identifier: 21368207
author list: Gobler CJ, Berry DL, Dyhrman ST, Wilhelm SW, Salamov A, Lobanov AV, Zhang Y, Collier JL, Wurch LL, Kustka AB, Dill BD, Shah M, VerBerkmoes NC, Kuo A, Terry A, Pangilinan J, Lindquist EA, Lucas S, Paulsen IT, Hattenrath-Lehmann TK, Talmage SC, Walker EA, Koch F, Burson AM, Marcoval MA, Tang YZ, Lecleir GR, Coyne KJ, Berg GM, Bertrand EM, Saito MA, Gladyshev VN, Grigoriev IV
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4352-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2011-02-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines.
PubMed Identifier: 21393246
author list: Lee BC, Lobanov AV, Marino SM, Kaya A, Seravalli J, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines. J Biol Chem. 2011 May 27; 286(21):18747-55.
journal title abbreviation: J Biol Chem
publication date: 2011-03-10T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

The second international conference "genetics of aging and longevity".
PubMed Identifier: 22661237
author list: Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P
published in: Aging
information resource reference: The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17.
journal title abbreviation: Aging (Albany NY)
publication date: 2012-05-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1112960
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Aging and drug discovery.

Authorship 1114357
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: A whole lifespan mouse multi-tissue DNA methylation clock.

Aging and drug discovery.
PubMed Identifier: 30425188
author list: Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M
published in: Aging
information resource reference: Aging and drug discovery. Aging (Albany NY). 2018 11 13; 10(11):3079-3088.
journal title abbreviation: Aging (Albany NY)
publication date: 2018-11-13T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

A whole lifespan mouse multi-tissue DNA methylation clock.
PubMed Identifier: 30427307
author list: Meer MV, Podolskiy DI, Tyshkovskiy A, Gladyshev VN
published in: eLife
information resource reference: A whole lifespan mouse multi-tissue DNA methylation clock. Elife. 2018 11 14; 7.
journal title abbreviation: Elife
publication date: 2018-11-14T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Genomics perspective on disulfide bond formation.
PubMed Identifier: 13678527
author list: Fomenko DE, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Genomics perspective on disulfide bond formation. Antioxid Redox Signal. 2003 Aug; 5(4):397-402.
journal title abbreviation: Antioxid Redox Signal
publication date: 2003-08-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase.
PubMed Identifier: 16262253
author list: Sun QA, Su D, Novoselov SV, Carlson BA, Hatfield DL, Gladyshev VN
published in: Biochemistry
information resource reference: Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry. 2005 Nov 08; 44(44):14528-37.
journal title abbreviation: Biochemistry
publication date: 2005-11-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein expression is essential in endothelial cell development and cardiac muscle function.
PubMed Identifier: 17142041
author list: Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, Hatfield DL
published in: Neuromuscular disorders : NMD
information resource reference: Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord. 2007 Feb; 17(2):135-42.
journal title abbreviation: Neuromuscul Disord
publication date: 2006-12-04T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.
PubMed Identifier: 18990697
author list: Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27; 284(9):5986-93.
journal title abbreviation: J Biol Chem
publication date: 2008-11-06T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2.
PubMed Identifier: 19636904
author list: Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, del Conte R, Gladyshev VN, Dikiy A
published in: Biomolecular NMR assignments
information resource reference: 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec; 2(2):199-201.
journal title abbreviation: Biomol NMR Assign
publication date: 2008-10-04T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development.
PubMed Identifier: 19783940
author list: Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL
published in: Molecules (Basel, Switzerland)
information resource reference: Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development. Molecules. 2009 Sep 10; 14(9):3509-27.
journal title abbreviation: Molecules
publication date: 2009-09-10T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.
PubMed Identifier: 20609915
author list: Yoo MH, Carlson BA, Tsuji P, Irons R, Gladyshev VN, Hatfield DL
published in: Methods in enzymology
information resource reference: Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. Methods Enzymol. 2010; 474:255-75.
journal title abbreviation: Methods Enzymol
publication date: 2010-06-20T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.
PubMed Identifier: 21453190
author list: Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H
published in: Antioxidants & redox signaling
information resource reference: Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011 Nov 01; 15(9):2565-604.
journal title abbreviation: Antioxid Redox Signal
publication date: 2011-06-08T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 126479
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases.

Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.
PubMed Identifier: 21768092
author list: Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12.
journal title abbreviation: J Biol Chem
publication date: 2011-07-18T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.
PubMed Identifier: 22628550
author list: Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding. J Biol Chem. 2012 Jul 13; 287(29):24448-59.
journal title abbreviation: J Biol Chem
publication date: 2012-05-24T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1119982
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Protein synthesis and quality control in aging.

Protein synthesis and quality control in aging.
PubMed Identifier: 30562164
author list: Anisimova AS, Alexandrov AI, Makarova NE, Gladyshev VN, Dmitriev SE
published in: Aging
information resource reference: Protein synthesis and quality control in aging. Aging (Albany NY). 2018 12 18; 10(12):4269-4288.
journal title abbreviation: Aging (Albany NY)
publication date: 2018-12-18T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase.
PubMed Identifier: 9927654
author list: Gladyshev VN, Stadtman TC, Hatfield DL, Jeang KT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):835-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1999-02-02T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology.
PubMed Identifier: 10945981
author list: Kumaraswamy E, Malykh A, Korotkov KV, Kozyavkin S, Hu Y, Kwon SY, Moustafa ME, Carlson BA, Berry MJ, Lee BJ, Hatfield DL, Diamond AM, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. J Biol Chem. 2000 Nov 10; 275(45):35540-7.
journal title abbreviation: J Biol Chem
publication date: 2000-11-10T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.
PubMed Identifier: 11168591
author list: Kryukov GV, Gladyshev VN
published in: Genes to cells : devoted to molecular & cellular mechanisms
information resource reference: Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000 Dec; 5(12):1049-60.
journal title abbreviation: Genes Cells
publication date: 2000-12-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic and functional analysis of mammalian Sep15 selenoprotein.
PubMed Identifier: 11898406
author list: Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL
published in: Methods in enzymology
information resource reference: Genetic and functional analysis of mammalian Sep15 selenoprotein. Methods Enzymol. 2002; 347:187-97.
journal title abbreviation: Methods Enzymol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The prokaryotic selenoproteome.
PubMed Identifier: 15105824
author list: Kryukov GV, Gladyshev VN
published in: EMBO reports
information resource reference: The prokaryotic selenoproteome. EMBO Rep. 2004 May; 5(5):538-43.
journal title abbreviation: EMBO Rep
publication date: 2004-04-23T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Pyrrolysine and selenocysteine use dissimilar decoding strategies.
PubMed Identifier: 15788401
author list: Zhang Y, Baranov PV, Atkins JF, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Pyrrolysine and selenocysteine use dissimilar decoding strategies. J Biol Chem. 2005 May 27; 280(21):20740-51.
journal title abbreviation: J Biol Chem
publication date: 2005-03-22T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.
PubMed Identifier: 16170372
author list: Novoselov SV, Calvisi DF, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN
published in: Oncogene
information resource reference: Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 2005 Dec 01; 24(54):8003-11.
journal title abbreviation: Oncogene
publication date: 2005-12-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals.
PubMed Identifier: 17922679
author list: Kim HY, Gladyshev VN
published in: The Biochemical journal
information resource reference: Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J. 2007 Nov 01; 407(3):321-9.
journal title abbreviation: Biochem J
publication date: 2007-11-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.
PubMed Identifier: 18408002
author list: Bonilla M, Denicola A, Novoselov SV, Turanov AA, Protasio A, Izmendi D, Gladyshev VN, Salinas G
published in: The Journal of biological chemistry
information resource reference: Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem. 2008 Jun 27; 283(26):17898-907.
journal title abbreviation: J Biol Chem
publication date: 2008-04-11T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional characterization of alternatively spliced human SECISBP2 transcript variants.
PubMed Identifier: 19004874
author list: Papp LV, Wang J, Kennedy D, Boucher D, Zhang Y, Gladyshev VN, Singh RN, Khanna KK
published in: Nucleic acids research
information resource reference: Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res. 2008 Dec; 36(22):7192-206.
journal title abbreviation: Nucleic Acids Res
publication date: 2008-11-12T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function.
PubMed Identifier: 19459624
author list: Zhang Y, Gladyshev VN
published in: Chemical reviews
information resource reference: Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function. Chem Rev. 2009 Oct; 109(10):4828-61.
journal title abbreviation: Chem Rev
publication date: 2009-10-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Eukaryotic selenoproteins and selenoproteomes.
PubMed Identifier: 19477234
author list: Lobanov AV, Hatfield DL, Gladyshev VN
published in: Biochimica et biophysica acta
information resource reference: Eukaryotic selenoproteins and selenoproteomes. Biochim Biophys Acta. 2009 Nov; 1790(11):1424-8.
journal title abbreviation: Biochim Biophys Acta
publication date: 2009-05-27T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

dbTEU: a protein database of trace element utilization.
PubMed Identifier: 20053843
author list: Zhang Y, Gladyshev VN
published in: Bioinformatics (Oxford, England)
information resource reference: dbTEU: a protein database of trace element utilization. Bioinformatics. 2010 Mar 01; 26(5):700-2.
journal title abbreviation: Bioinformatics
publication date: 2010-01-06T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Redox biology: computational approaches to the investigation of functional cysteine residues.
PubMed Identifier: 20812876
author list: Marino SM, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal. 2011 Jul 01; 15(1):135-46.
journal title abbreviation: Antioxid Redox Signal
publication date: 2011-04-14T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression.
PubMed Identifier: 21372135
author list: Kasaikina MV, Lobanov AV, Malinouski MY, Lee BC, Seravalli J, Fomenko DE, Turanov AA, Finney L, Vogt S, Park TJ, Miller RA, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression. J Biol Chem. 2011 May 13; 286(19):17005-14.
journal title abbreviation: J Biol Chem
publication date: 2011-03-03T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.
PubMed Identifier: 22114689
author list: Uluisik I, Kaya A, Fomenko DE, Karakaya HC, Carlson BA, Gladyshev VN, Koc A
published in: PloS one
information resource reference: Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One. 2011; 6(11):e27772.
journal title abbreviation: PLoS One
publication date: 2011-11-17T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice.
PubMed Identifier: 23226526
author list: Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko DE, Gladyshev VN, Hatfield DL, Davis CD
published in: PloS one
information resource reference: Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. PLoS One. 2012; 7(12):e50574.
journal title abbreviation: PLoS One
publication date: 2012-12-04T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1128755
type: Authorship
author rank in publication: 14
linked author: Gladyshev, Vadim
linked information resource: Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation.
PubMed Identifier: 30707697
author list: O'Connell AE, Gerashchenko MV, O'Donohue MF, Rosen SM, Huntzinger E, Gleeson D, Galli A, Ryder E, Cao S, Murphy Q, Kazerounian S, Morton SU, Schmitz-Abe K, Gladyshev VN, Gleizes PE, Séraphin B, Agrawal PB
published in: PLoS genetics
information resource reference: Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PLoS Genet. 2019 02; 15(2):e1007917.
journal title abbreviation: PLoS Genet
publication date: 2019-02-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1133006
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Utilization of selenocysteine in early-branching fungal phyla.

Utilization of selenocysteine in early-branching fungal phyla.
PubMed Identifier: 30742068
author list: Mariotti M, Salinas G, Gabaldón T, Gladyshev VN
published in: Nature microbiology
information resource reference: Utilization of selenocysteine in early-branching fungal phyla. Nat Microbiol. 2019 05; 4(5):759-765.
journal title abbreviation: Nat Microbiol
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linked information resource: Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins.

Authorship 1138002
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
PubMed Identifier: 30853213
author list: Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V
published in: Cell metabolism
information resource reference: LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metab. 2019 04 02; 29(4):871-885.e5.
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Selenoproteins
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MeSH semantic group name: Chemicals & Drugs
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Selenocysteine
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Longevity
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Authorship 114213
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linked information resource: CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function.

Methionine Sulfoxide Reductases
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Selenium
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Authorship 1141796
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linked information resource: SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Authorship 1144983
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linked information resource: svist4get: a simple visualization tool for genomic tracks from sequencing experiments.

svist4get: a simple visualization tool for genomic tracks from sequencing experiments.
PubMed Identifier: 30841857
author list: Egorov AA, Sakharova EA, Anisimova AS, Dmitriev SE, Gladyshev VN, Kulakovskiy IV
published in: BMC bioinformatics
information resource reference: svist4get: a simple visualization tool for genomic tracks from sequencing experiments. BMC Bioinformatics. 2019 Mar 06; 20(1):113.
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SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
PubMed Identifier: 31002797
author list: Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V
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information resource reference: SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 2019 04 18; 177(3):622-638.e22.
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Loscalzo, Joseph
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Green, Robert
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Kang, Hyuck Joon
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Bulyk, Martha
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Authorship 1158036
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linked information resource: Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.
PubMed Identifier: 31141699
author list: Yim SH, Clish CB, Gladyshev VN
published in: Cell reports
information resource reference: Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019 05 28; 27(9):2785-2797.e3.
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Baccarelli, Andrea
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Gygi, Steven
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Kucherlapati, Melanie
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Li, Zhe
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Perrimon, Norbert
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Authorship 132123
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.

Authorship 1177435
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Reversibility of irreversible aging.

Authorship 1176933
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
PubMed Identifier: 31353263
author list: Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN
published in: Cell metabolism
information resource reference: Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metab. 2019 09 03; 30(3):573-593.e8.
journal title abbreviation: Cell Metab
publication date: 2019-07-25T00:00:00
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Reversibility of irreversible aging.
PubMed Identifier: 30513346
author list: Galkin F, Zhang B, Dmitriev SE, Gladyshev VN
published in: Ageing research reviews
information resource reference: Reversibility of irreversible aging. Ageing Res Rev. 2019 01; 49:104-114.
journal title abbreviation: Ageing Res Rev
publication date: 2018-12-01T00:00:00
year: 2018
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Authorship 136643
type: Authorship
author rank in publication: 2
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linked information resource: The biological significance of methionine sulfoxide stereochemistry.

Authorship 146420
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase.

Authorship 1184675
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.

Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs.
PubMed Identifier: 31442478
author list: Baclaocos J, Santesmasses D, Mariotti M, Bierla K, Vetick MB, Lynch S, McAllen R, Mackrill JJ, Loughran G, Guigó R, Szpunar J, Copeland PR, Gladyshev VN, Atkins JF
published in: Journal of molecular biology
information resource reference: Processive Recoding and Metazoan Evolution of Selenoprotein P: Up to 132 UGAs in Molluscs. J Mol Biol. 2019 11 08; 431(22):4381-4407.
journal title abbreviation: J Mol Biol
publication date: 2019-08-20T00:00:00
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Authorship 151749
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linked author: Gladyshev, Vadim
linked information resource: Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function.

Authorship 1192646
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Tolerance to Selenoprotein Loss Differs between Human and Mouse.

Tolerance to Selenoprotein Loss Differs between Human and Mouse.
PubMed Identifier: 31560400
author list: Santesmasses D, Mariotti M, Gladyshev VN
published in: Molecular biology and evolution
information resource reference: Tolerance to Selenoprotein Loss Differs between Human and Mouse. Mol Biol Evol. 2020 02 01; 37(2):341-354.
journal title abbreviation: Mol Biol Evol
publication date: 2020-02-01T00:00:00
year: 2020
type: Academic Article
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Authorship 154542
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression.

Authorship 1198108
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
PubMed Identifier: 29991649
author list: Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS
published in: Science signaling
information resource reference: Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Sci Signal. 2018 07 10; 11(538).
journal title abbreviation: Sci Signal
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Instructor in Medicine
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Instructor in Medicine
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Professor of Medicine
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Authorship 1206670
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linked information resource: Latest advances in aging research and drug discovery.

Latest advances in aging research and drug discovery.
PubMed Identifier: 31770722
author list: Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M
published in: Aging
information resource reference: Latest advances in aging research and drug discovery. Aging (Albany NY). 2019 11 21; 11(22):9971-9981.
journal title abbreviation: Aging (Albany NY)
publication date: 2019-11-21T00:00:00
year: 2019
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DNA methylation aging clocks: challenges and recommendations.
PubMed Identifier: 31767039
author list: Bell CG, Lowe R, Adams PD, Baccarelli AA, Beck S, Bell JT, Christensen BC, Gladyshev VN, Heijmans BT, Horvath S, Ideker T, Issa JJ, Kelsey KT, Marioni RE, Reik W, Relton CL, Schalkwyk LC, Teschendorff AE, Wagner W, Zhang K, Rakyan VK
published in: Genome biology
information resource reference: DNA methylation aging clocks: challenges and recommendations. Genome Biol. 2019 11 25; 20(1):249.
journal title abbreviation: Genome Biol
publication date: 2019-11-25T00:00:00
year: 2019
type: Academic Article
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Authorship 148216
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait.

Authorship 1210229
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.
PubMed Identifier: 31855834
author list: Smekalova EM, Gerashchenko MV, O'Connor PBF, Whittaker CA, Kauffman KJ, Fefilova AS, Zatsepin TS, Bogorad RL, Baranov PV, Langer R, Gladyshev VN, Anderson DG, Koteliansky V
published in: Molecular therapy. Nucleic acids
information resource reference: In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation. Mol Ther Nucleic Acids. 2020 Mar 06; 19:252-266.
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Unbiased identification of interventions that extend lifespan
end date: 2025-05-31
principal investigator name: GLADYSHEV, VADIM N.
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Principal Investigator
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Authorship 1214078
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linked information resource: Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.

Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.
PubMed Identifier: 31875539
author list: Kinzina ED, Podolskiy DI, Dmitriev SE, Gladyshev VN
published in: Cell reports
information resource reference: Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality. Cell Rep. 2019 12 24; 29(13):4276-4284.e3.
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Authorship 1222237
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linked information resource: Molecular signatures of aneuploidy-driven adaptive evolution.

Molecular signatures of aneuploidy-driven adaptive evolution.
PubMed Identifier: 32001709
author list: Kaya A, Mariotti M, Tyshkovskiy A, Zhou X, Hulke ML, Ma S, Gerashchenko MV, Koren A, Gladyshev VN
published in: Nature communications
information resource reference: Molecular signatures of aneuploidy-driven adaptive evolution. Nat Commun. 2020 01 30; 11(1):588.
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Authorship 1223208
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linked information resource: Bioinformatics of Selenoproteins.

Bioinformatics of Selenoproteins.
PubMed Identifier: 32031018
author list: Santesmasses D, Mariotti M, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Bioinformatics of Selenoproteins. Antioxid Redox Signal. 2020 09 01; 33(7):525-536.
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Authorship 1233300
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linked information resource: DNA methylation aging clocks: challenges and recommendations.

Authorship 1235309
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linked information resource: Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.

Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.
PubMed Identifier: 32208164
author list: Fernando R, Wardelmann K, Deubel S, Kehm R, Jung T, Mariotti M, Vasilaki A, Gladyshev VN, Kleinridders A, Grune T, Castro JP
published in: Redox biology
information resource reference: Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol. 2020 05; 32:101507.
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Authorship 167398
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linked information resource: Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology.

Authorship 1239260
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linked information resource: Germline burden of rare damaging variants negatively affects human healthspan and lifespan.

Germline burden of rare damaging variants negatively affects human healthspan and lifespan.
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author list: Shindyapina AV, Zenin AA, Tarkhov AE, Santesmasses D, Fedichev PO, Gladyshev VN
published in: eLife
information resource reference: Germline burden of rare damaging variants negatively affects human healthspan and lifespan. Elife. 2020 04 07; 9.
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Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks.
PubMed Identifier: 32323920
author list: Zhang B, Podolskiy DI, Mariotti M, Seravalli J, Gladyshev VN
published in: Aging cell
information resource reference: Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks. Aging Cell. 2020 05; 19(5):e13119.
journal title abbreviation: Aging Cell
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Authorship 1241174
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linked information resource: Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks.

Authorship 1243672
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linked information resource: Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
PubMed Identifier: 32358195
author list: Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10789-10796.
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Authorship 1245235
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linked information resource: High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.

High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E.
PubMed Identifier: 32384218
author list: Bozaykut P, Ekren R, Sezerman OU, Gladyshev VN, Ozer NK
published in: BioFactors (Oxford, England)
information resource reference: High-throughput profiling reveals perturbation of endoplasmic reticulum stress-related genes in atherosclerosis induced by high-cholesterol diet and the protective role of vitamin E. Biofactors. 2020 Jul; 46(4):653-664.
journal title abbreviation: Biofactors
publication date: 2020-05-08T00:00:00
year: 2020
type: Academic Article
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Authorship 193476
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linked information resource: Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes.

Authorship 1252254
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linked information resource: N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.

Authorship 1253477
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linked information resource: An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo*.

N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.
PubMed Identifier: 32494643
author list: Liberman N, O'Brown ZK, Earl AS, Boulias K, Gerashchenko MV, Wang SY, Fritsche C, Fady PE, Dong A, Gladyshev VN, Greer EL
published in: Science advances
information resource reference: N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Sci Adv. 2020 04; 6(17):eaaz4370.
journal title abbreviation: Sci Adv
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An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo*.
PubMed Identifier: 32501570
author list: Sánchez-López C, Labadie N, Lombardo VA, Biglione FA, Manta B, Jacob RS, Gladyshev VN, Abdelilah-Seyfried S, Selenko P, Binolfi A
published in: Chemistry (Weinheim an der Bergstrasse, Germany)
information resource reference: An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo*. Chemistry. 2020 Nov 20; 26(65):14838-14843.
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Authorship 206173
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linked author: Gladyshev, Vadim
linked information resource: Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1.

Authorship 1255002
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.

CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.
PubMed Identifier: 32560154
author list: Lashkevich KA, Shlyk VI, Kushchenko AS, Gladyshev VN, Alkalaeva EZ, Dmitriev SE
published in: Biomolecules
information resource reference: CTELS: A Cell-Free System for the Analysis of Translation Termination Rate. Biomolecules. 2020 06 16; 10(6).
journal title abbreviation: Biomolecules
publication date: 2020-06-16T00:00:00
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Authorship 147141
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linked author: Gladyshev, Vadim
linked information resource: Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.

Authorship 1257946
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linked author: Gladyshev, Vadim
linked information resource: Multifaceted deregulation of gene expression and protein synthesis with age.

Multifaceted deregulation of gene expression and protein synthesis with age.
PubMed Identifier: 32576685
author list: Anisimova AS, Meerson MB, Gerashchenko MV, Kulakovskiy IV, Dmitriev SE, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Multifaceted deregulation of gene expression and protein synthesis with age. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15581-15590.
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Authorship 1268913
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author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
PubMed Identifier: 32693105
author list: Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T
published in: Mechanisms of ageing and development
information resource reference: Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 2020 10; 191:111316.
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Authorship 154987
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author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec.

Organ-Specific Biological Age and Its Applications
end date: 2031-01-31
principal investigator name: HIGGINS-CHEN, ALBERT TZONGYANG
start date: 2020-08-01
type: Grant
sponsor award id: R01AG065403

Role of rare damaging mutations in aging
end date: 2025-05-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2020-08-01
type: Grant
sponsor award id: R01AG064223

Co-Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Organ-Specific Biological Age and Its Applications

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Role of rare damaging mutations in aging

Authorship 1271294
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author rank in publication: 16
linked author: Gladyshev, Vadim
linked information resource: Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.

Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.
PubMed Identifier: 32726638
author list: Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN
published in: Cell reports
information resource reference: Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep. 2020 07 28; 32(4):107949.
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Authorship 1274169
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linked author: Gladyshev, Vadim
linked information resource: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.

MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
PubMed Identifier: 32749237
author list: Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME
published in: The Journal of clinical investigation
information resource reference: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. J Clin Invest. 2020 09 01; 130(9):4663-4678.
journal title abbreviation: J Clin Invest
publication date: 2020-09-01T00:00:00
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Professor of Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Cell Biology
position in organization: Harvard Medical School

Authorship 1289642
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author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.

Authorship 1289577
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author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: The conundrum of human immune system "senescence".

The conundrum of human immune system "senescence".
PubMed Identifier: 32949594
author list: Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA
published in: Mechanisms of ageing and development
information resource reference: The conundrum of human immune system "senescence". Mech Ageing Dev. 2020 12; 192:111357.
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publication date: 2020-09-17T00:00:00
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Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
PubMed Identifier: 32968084
author list: Gerashchenko MV, Nesterchuk MV, Smekalova EM, Paulo JA, Kowalski PS, Akulich KA, Bogorad R, Dmitriev SE, Gygi S, Zatsepin T, Anderson DG, Gladyshev VN, Koteliansky VE
published in: Scientific reports
information resource reference: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Sci Rep. 2020 09 23; 10(1):15473.
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Authorship 1292256
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author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: The Ground Zero of Organismal Life and Aging.

Authorship 1291918
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: COVID-19 is an emergent disease of aging.

COVID-19 is an emergent disease of aging.
PubMed Identifier: 33006233
author list: Santesmasses D, Castro JP, Zenin AA, Shindyapina AV, Gerashchenko MV, Zhang B, Kerepesi C, Yim SH, Fedichev PO, Gladyshev VN
published in: Aging cell
information resource reference: COVID-19 is an emergent disease of aging. Aging Cell. 2020 10; 19(10):e13230.
journal title abbreviation: Aging Cell
publication date: 2020-10-01T00:00:00
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type: Document
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The Ground Zero of Organismal Life and Aging.
PubMed Identifier: 32980264
author list: Gladyshev VN
published in: Trends in molecular medicine
information resource reference: The Ground Zero of Organismal Life and Aging. Trends Mol Med. 2021 01; 27(1):11-19.
journal title abbreviation: Trends Mol Med
publication date: 2020-09-23T00:00:00
year: 2020
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Authorship 144207
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.

Authorship 139984
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.

Authorship 1308070
type: Authorship
author rank in publication: 23
linked author: Gladyshev, Vadim
linked information resource: Reprogramming to recover youthful epigenetic information and restore vision.

Authorship 1308880
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Translation elongation rate varies among organs and decreases with age.

Translation elongation rate varies among organs and decreases with age.
PubMed Identifier: 33264395
author list: Gerashchenko MV, Peterfi Z, Yim SH, Gladyshev VN
published in: Nucleic acids research
information resource reference: Translation elongation rate varies among organs and decreases with age. Nucleic Acids Res. 2021 01 25; 49(2):e9.
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publication date: 2021-01-25T00:00:00
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type: Academic Article
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type: Document
type: Information Resource

Reprogramming to recover youthful epigenetic information and restore vision.
PubMed Identifier: 33268865
author list: Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA
published in: Nature
information resource reference: Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 12; 588(7836):124-129.
journal title abbreviation: Nature
publication date: 2020-12-02T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Poganik, Jesse
eCommons Login: jep856
first name: Jesse
last name: Poganik
full name: Jesse R. Poganik, Ph.D.
has faculty rank: Instructor
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
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person in primary position: Instructor in Medicine
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preferred title: Instructor in Medicine

Authorship 1314924
type: Authorship
author rank in publication: 19
linked author: Gladyshev, Vadim
linked information resource: ARDD 2020: from aging mechanisms to interventions.

ARDD 2020: from aging mechanisms to interventions.
PubMed Identifier: 33378272
author list: Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
published in: Aging
information resource reference: ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 12 30; 12(24):24484-24503.
journal title abbreviation: Aging (Albany NY)
publication date: 2020-12-30T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 160658
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Hydrogen peroxide probes directed to different cellular compartments.

Authorship 1328717
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.

Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.
PubMed Identifier: 33571808
author list: Choi DW, Roh YJ, Kim S, Lee HM, Kim M, Shin D, Park JH, Cho Y, Park HH, Ok YS, Kang D, Kim JH, Tarrago L, Danial NN, Gladyshev VN, Min PK, Lee BC
published in: Biosensors & bioelectronics
information resource reference: Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues. Biosens Bioelectron. 2021 Apr 15; 178:113031.
journal title abbreviation: Biosens Bioelectron
publication date: 2021-01-29T00:00:00
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type: Information Resource

Authorship 1331410
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.

Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.
PubMed Identifier: 33608273
author list: Augereau A, Mariotti M, Pousse M, Filipponi D, Libert F, Beck B, Gorbunova V, Gilson E, Gladyshev VN
published in: Science advances
information resource reference: Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci Adv. 2021 02; 7(8).
journal title abbreviation: Sci Adv
publication date: 2021-02-19T00:00:00
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Authorship 201802
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing.

Authorship 154263
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author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins.

Authorship 1335479
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: James R. Mitchell (1971-2020).

James R. Mitchell (1971-2020).
PubMed Identifier: 33657387
author list: Ristow M, Lee CH, De Bock K, Gladyshev VN, Hotamisligil GS, Manning BD
published in: Cell metabolism
information resource reference: James R. Mitchell (1971-2020). Cell Metab. 2021 03 02; 33(3):458-461.
journal title abbreviation: Cell Metab
publication date: 2021-03-02T00:00:00
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type: Article
type: Document
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Authorship 1342113
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates.

Authorship 1342221
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Measuring Organ-Specific Translation Elongation Rate in Mice.

Measuring Organ-Specific Translation Elongation Rate in Mice.
PubMed Identifier: 33765276
author list: Gerashchenko MV, Gladyshev VN
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Measuring Organ-Specific Translation Elongation Rate in Mice. Methods Mol Biol. 2021; 2252:189-200.
journal title abbreviation: Methods Mol Biol
publication date: 2021-01-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates.
PubMed Identifier: 33765281
author list: Vorontsov IE, Egorov AA, Anisimova AS, Eliseeva IA, Makeev VJ, Gladyshev VN, Dmitriev SE, Kulakovskiy IV
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates. Methods Mol Biol. 2021; 2252:269-294.
journal title abbreviation: Methods Mol Biol
publication date: 2021-01-01T00:00:00
year: 2021
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type: Article
type: Document
type: Information Resource

Authorship 167350
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.

Authorship 1364211
type: Authorship
author rank in publication: 24
linked author: Gladyshev, Vadim
linked information resource: A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription.

A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription.
PubMed Identifier: 34140474
author list: Jin L, Tang Q, Hu S, Chen Z, Zhou X, Zeng B, Wang Y, He M, Li Y, Gui L, Shen L, Long K, Ma J, Wang X, Chen Z, Jiang Y, Tang G, Zhu L, Liu F, Zhang B, Huang Z, Li G, Li D, Gladyshev VN, Yin J, Gu Y, Li X, Li M
published in: Nature communications
information resource reference: A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription. Nat Commun. 2021 06 17; 12(1):3715.
journal title abbreviation: Nat Commun
publication date: 2021-06-17T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1373234
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.

Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
PubMed Identifier: 34172448
author list: Kerepesi C, Zhang B, Lee SG, Trapp A, Gladyshev VN
published in: Science advances
information resource reference: Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci Adv. 2021 Jun; 7(26).
journal title abbreviation: Sci Adv
publication date: 2021-06-25T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1375061
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis).

A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis).
PubMed Identifier: 34247236
author list: Tian R, Han K, Geng Y, Yang C, Guo H, Shi C, Xu S, Yang G, Zhou X, Gladyshev VN, Liu X, Chopin LK, Fisher DO, Baker AM, Leiner NO, Fan G, Seim I
published in: Genome biology and evolution
information resource reference: A Chromosome-Level Genome of the Agile Gracile Mouse Opossum (Gracilinanus agilis). Genome Biol Evol. 2021 08 03; 13(8).
journal title abbreviation: Genome Biol Evol
publication date: 2021-08-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
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Authorship 1387359
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: COVID-19 mortality rate in children is U-shaped.

COVID-19 mortality rate in children is U-shaped.
PubMed Identifier: 34411000
author list: Khera N, Santesmasses D, Kerepesi C, Gladyshev VN
published in: Aging
information resource reference: COVID-19 mortality rate in children is U-shaped. Aging (Albany NY). 2021 08 18; 13(16):19954-19962.
journal title abbreviation: Aging (Albany NY)
publication date: 2021-08-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 167089
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Comparative genomics of trace element dependence in biology.

Authorship 1394741
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating.

A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating.
PubMed Identifier: 34486812
author list: Tian R, Han K, Geng Y, Yang C, Shi C, Thomas PB, Pearce C, Moffatt K, Ma S, Xu S, Yang G, Zhou X, Gladyshev VN, Liu X, Fisher DO, Chopin LK, Leiner NO, Baker AM, Fan G, Seim I
published in: Molecular ecology resources
information resource reference: A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating. Mol Ecol Resour. 2022 Feb; 22(2):740-754.
journal title abbreviation: Mol Ecol Resour
publication date: 2021-09-21T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1395858
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Applying deductive reasoning and the principles of particle physics to aging research.

Applying deductive reasoning and the principles of particle physics to aging research.
PubMed Identifier: 34543232
author list: Moldakozhayev A, Tskhay A, Gladyshev VN
published in: Aging
information resource reference: Applying deductive reasoning and the principles of particle physics to aging research. Aging (Albany NY). 2021 09 20; 13(18):22611-22622.
journal title abbreviation: Aging (Albany NY)
publication date: 2021-09-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1399039
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: A standard knockout procedure alters expression of adjacent loci at the translational level.

Authorship 1398987
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Ectopic cervical thymi and no thymic involution until midlife in naked mole rats.

A standard knockout procedure alters expression of adjacent loci at the translational level.
PubMed Identifier: 34606617
author list: Egorov AA, Alexandrov AI, Urakov VN, Makeeva DS, Edakin RO, Kushchenko AS, Gladyshev VN, Kulakovskiy IV, Dmitriev SE
published in: Nucleic acids research
information resource reference: A standard knockout procedure alters expression of adjacent loci at the translational level. Nucleic Acids Res. 2021 11 08; 49(19):11134-11144.
journal title abbreviation: Nucleic Acids Res
publication date: 2021-11-08T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Ectopic cervical thymi and no thymic involution until midlife in naked mole rats.
PubMed Identifier: 34596321
author list: Emmrich S, Tolibzoda Zakusilo F, Trapp A, Zhou X, Zhang Q, Irving EM, Drage MG, Zhang Z, Gladyshev VN, Seluanov A, Gorbunova V
published in: Aging cell
information resource reference: Ectopic cervical thymi and no thymic involution until midlife in naked mole rats. Aging Cell. 2021 10; 20(10):e13477.
journal title abbreviation: Aging Cell
publication date: 2021-10-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 18724
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes.

Authorship 1402988
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity.

Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity.
PubMed Identifier: 34638991
author list: Canter JA, Ernst SE, Peters KM, Carlson BA, Thielman NRJ, Grysczyk L, Udofe P, Yu Y, Cao L, Davis CD, Gladyshev VN, Hatfield DL, Tsuji PA
published in: International journal of molecular sciences
information resource reference: Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity. Int J Mol Sci. 2021 Sep 30; 22(19).
journal title abbreviation: Int J Mol Sci
publication date: 2021-09-30T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 198523
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.

Authorship 1406272
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Maintenance of genome sequence integrity in long- and short-lived rodent species.

Maintenance of genome sequence integrity in long- and short-lived rodent species.
PubMed Identifier: 34705500
author list: Zhang L, Dong X, Tian X, Lee M, Ablaeva J, Firsanov D, Lee SG, Maslov AY, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J
published in: Science advances
information resource reference: Maintenance of genome sequence integrity in long- and short-lived rodent species. Sci Adv. 2021 Oct 29; 7(44):eabj3284.
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publication date: 2021-10-27T00:00:00
year: 2021
type: Academic Article
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type: Information Resource

Authorship 223890
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author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.

Authorship 1409972
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery.

Authorship 1413469
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author rank in publication: 16
linked author: Gladyshev, Vadim
linked information resource: Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast.

Authorship 1413729
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author rank in publication: 16
linked author: Gladyshev, Vadim
linked information resource: Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.

Authorship 1414980
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.

Authorship 1412527
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author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1-/- Mice.

Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery.
PubMed Identifier: 34769022
author list: Santesmasses D, Gladyshev VN
published in: International journal of molecular sciences
information resource reference: Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery. Int J Mol Sci. 2021 Oct 27; 22(21).
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publication date: 2021-10-27T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1-/- Mice.
PubMed Identifier: 34769078
author list: Bang J, Han M, Yoo TJ, Qiao L, Jung J, Na J, Carlson BA, Gladyshev VN, Hatfield DL, Kim JH, Kim LK, Lee BJ
published in: International journal of molecular sciences
information resource reference: Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1-/- Mice. Int J Mol Sci. 2021 Oct 28; 22(21).
journal title abbreviation: Int J Mol Sci
publication date: 2021-10-28T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
PubMed Identifier: 34758328
author list: Zhang Q, Tombline G, Ablaeva J, Zhang L, Zhou X, Smith Z, Zhao Y, Xiaoli AM, Wang Z, Lin JR, Jabalameli MR, Mitra J, Nguyen N, Vijg J, Seluanov A, Gladyshev VN, Gorbunova V, Zhang ZD
published in: Cell reports
information resource reference: Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation. Cell Rep. 2021 11 09; 37(6):109965.
journal title abbreviation: Cell Rep
publication date: 2021-11-09T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation.
PubMed Identifier: 34733838
author list: Omotoso O, Gladyshev VN, Zhou X
published in: Frontiers in cell and developmental biology
information resource reference: Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation. Front Cell Dev Biol. 2021; 9:704966.
journal title abbreviation: Front Cell Dev Biol
publication date: 2021-10-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast.
PubMed Identifier: 34751131
author list: Kaya A, Phua CZJ, Lee M, Wang L, Tyshkovskiy A, Ma S, Barre B, Liu W, Harrison BR, Zhao X, Zhou X, Wasko BM, Bammler TK, Promislow DE, Kaeberlein M, Gladyshev VN
published in: eLife
information resource reference: Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast. Elife. 2021 11 09; 10.
journal title abbreviation: Elife
publication date: 2021-11-09T00:00:00
year: 2021
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type: Article
type: Document
type: Information Resource

Authorship 1421019
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author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: Biosensor-Linked Immunosorbent Assay for the Quantification of Methionine Oxidation in Target Proteins.

Biosensor-Linked Immunosorbent Assay for the Quantification of Methionine Oxidation in Target Proteins.
PubMed Identifier: 34936330
author list: Lee HM, Choi DW, Kim S, Lee A, Kim M, Roh YJ, Jo YH, Cho HY, Lee HJ, Lee SR, Tarrago L, Gladyshev VN, Kim JH, Lee BC
published in: ACS sensors
information resource reference: Biosensor-Linked Immunosorbent Assay for the Quantification of Methionine Oxidation in Target Proteins. ACS Sens. 2022 01 28; 7(1):131-141.
journal title abbreviation: ACS Sens
publication date: 2021-12-22T00:00:00
year: 2021
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type: Article
type: Document
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Authorship 1422599
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Emerging rejuvenation strategies-Reducing the biological age.

Emerging rejuvenation strategies-Reducing the biological age.
PubMed Identifier: 34972247
author list: Zhang B, Trapp A, Kerepesi C, Gladyshev VN
published in: Aging cell
information resource reference: Emerging rejuvenation strategies-Reducing the biological age. Aging Cell. 2022 01; 21(1):e13538.
journal title abbreviation: Aging Cell
publication date: 2021-12-31T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly.
PubMed Identifier: 35008430
author list: Tsuji PA, Santesmasses D, Lee BJ, Gladyshev VN, Hatfield DL
published in: International journal of molecular sciences
information resource reference: Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly. Int J Mol Sci. 2021 Dec 21; 23(1).
journal title abbreviation: Int J Mol Sci
publication date: 2021-12-21T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Epigenetic aging of the demographically non-aging naked mole-rat.
PubMed Identifier: 35039495
author list: Kerepesi C, Meer MV, Ablaeva J, Amoroso VG, Lee SG, Zhang B, Gerashchenko MV, Trapp A, Yim SH, Lu AT, Levine ME, Seluanov A, Horvath S, Park TJ, Gorbunova V, Gladyshev VN
published in: Nature communications
information resource reference: Epigenetic aging of the demographically non-aging naked mole-rat. Nat Commun. 2022 01 17; 13(1):355.
journal title abbreviation: Nat Commun
publication date: 2022-01-17T00:00:00
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type: Document
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Authorship 1424567
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linked author: Gladyshev, Vadim
linked information resource: Historical Roles of Selenium and Selenoproteins in Health and Development: The Good, the Bad and the Ugly.

Authorship 1425487
type: Authorship
author rank in publication: 16
linked author: Gladyshev, Vadim
linked information resource: Epigenetic aging of the demographically non-aging naked mole-rat.

Authorship 1431998
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author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.

Authorship 1432017
type: Authorship
author rank in publication: 23
linked author: Gladyshev, Vadim
linked information resource: Meeting Report: Aging Research and Drug Discovery.

Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.
PubMed Identifier: 35140209
author list: Kang D, Lee J, Jung J, Carlson BA, Chang MJ, Chang CB, Kang SB, Lee BC, Gladyshev VN, Hatfield DL, Lee BJ, Kim JH
published in: Nature communications
information resource reference: Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Nat Commun. 2022 02 09; 13(1):779.
journal title abbreviation: Nat Commun
publication date: 2022-02-09T00:00:00
year: 2022
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type: Article
type: Document
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Meeting Report: Aging Research and Drug Discovery.
PubMed Identifier: 35089871
author list: Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M
published in: Aging
information resource reference: Meeting Report: Aging Research and Drug Discovery. Aging (Albany NY). 2022 Jan 28; 14(2):530-543.
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publication date: 2022-01-28T00:00:00
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type: Academic Article
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type: Document
type: Information Resource

Authorship 257901
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.

Authorship 259207
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author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa.

Authorship 267114
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.

Authorship 288690
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Functional characterization of alternatively spliced human SECISBP2 transcript variants.

Authorship 1454262
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.

Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.
PubMed Identifier: 35602207
author list: Ying K, Zhai R, Pyrkov TV, Shindyapina AV, Mariotti M, Fedichev PO, Shen X, Gladyshev VN
published in: Communications medicine
information resource reference: Genetic and phenotypic analysis of the causal relationship between aging and COVID-19. Commun Med (Lond). 2021; 1:35.
journal title abbreviation: Commun Med (Lond)
publication date: 2021-10-05T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 353726
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases.

Authorship 384184
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.

Authorship 1463246
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice.

Authorship 1465322
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.

Authorship 1462976
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.
PubMed Identifier: 35753352
author list: Dou Q, Turanov AA, Mariotti M, Hwang JY, Wang H, Lee SG, Paulo JA, Yim SH, Gygi SP, Chung JJ, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem. 2022 08; 298(8):102183.
journal title abbreviation: J Biol Chem
publication date: 2022-06-23T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
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Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.
PubMed Identifier: 35694726
author list: Emmrich S, Trapp A, Tolibzoda Zakusilo F, Straight ME, Ying AK, Tyshkovskiy A, Mariotti M, Gray S, Zhang Z, Drage MG, Takasugi M, Klusmann JH, Gladyshev VN, Seluanov A, Gorbunova V
published in: The EMBO journal
information resource reference: Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits. EMBO J. 2022 08 01; 41(15):e109694.
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year: 2022
type: Academic Article
type: Article
type: Document
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Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice.
PubMed Identifier: 35643315
author list: Wang H, Dou Q, Jeong KJ, Choi J, Gladyshev VN, Chung JJ
published in: The Journal of biological chemistry
information resource reference: Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice. J Biol Chem. 2022 07; 298(7):102077.
journal title abbreviation: J Biol Chem
publication date: 2022-05-25T00:00:00
year: 2022
type: Academic Article
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type: Document
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Authorship 1498859
type: Authorship
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linked author: Gladyshev, Vadim
linked information resource: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna.

Authorship 1499291
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: The selenoprotein methionine sulfoxide reductase B1 (MSRB1).

Authorship 1501582
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Profiling epigenetic age in single cells.

Authorship 1485924
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: SEPHS1: Its evolution, function and roles in development and diseases.

Authorship 1484000
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.

The selenoprotein methionine sulfoxide reductase B1 (MSRB1).
PubMed Identifier: 36084791
author list: Tarrago L, Kaya A, Kim HY, Manta B, Lee BC, Gladyshev VN
published in: Free radical biology & medicine
information resource reference: The selenoprotein methionine sulfoxide reductase B1 (MSRB1). Free Radic Biol Med. 2022 10; 191:228-240.
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publication date: 2022-09-07T00:00:00
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type: Document
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Authorship 435142
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization.

Profiling epigenetic age in single cells.
PubMed Identifier: 36211119
author list: Trapp A, Kerepesi C, Gladyshev VN
published in: Nature aging
information resource reference: Profiling epigenetic age in single cells. Nat Aging. 2021 12; 1(12):1189-1201.
journal title abbreviation: Nat Aging
publication date: 2021-12-09T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

SEPHS1: Its evolution, function and roles in development and diseases.
PubMed Identifier: 36202216
author list: Bang J, Kang D, Jung J, Yoo TJ, Shim MS, Gladyshev VN, Tsuji PA, Hatfield DL, Kim JH, Lee BJ
published in: Archives of biochemistry and biophysics
information resource reference: SEPHS1: Its evolution, function and roles in development and diseases. Arch Biochem Biophys. 2022 11 15; 730:109426.
journal title abbreviation: Arch Biochem Biophys
publication date: 2022-10-04T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna.
PubMed Identifier: 36112674
author list: Shindyapina AV, Cho Y, Kaya A, Tyshkovskiy A, Castro JP, Deik A, Gordevicius J, Poganik JR, Clish CB, Horvath S, Peshkin L, Gladyshev VN
published in: Science advances
information resource reference: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna. Sci Adv. 2022 09 16; 8(37):eabo5482.
journal title abbreviation: Sci Adv
publication date: 2022-09-16T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
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Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.
PubMed Identifier: 36008942
author list: Santesmasses D, Gladyshev VN
published in: Biomolecules
information resource reference: Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6. Biomolecules. 2022 07 28; 12(8).
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publication date: 2022-07-28T00:00:00
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Authorship 1512469
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Epigenetic clocks, aging, and cancer.

Epigenetic clocks, aging, and cancer.
PubMed Identifier: 36548410
author list: Johnstone SE, Gladyshev VN, Aryee MJ, Bernstein BE
published in: Science (New York, N.Y.)
information resource reference: Epigenetic clocks, aging, and cancer. Science. 2022 12 23; 378(6626):1276-1277.
journal title abbreviation: Science
publication date: 2022-12-22T00:00:00
year: 2022
type: Academic Article
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Authorship 1517301
type: Authorship
author rank in publication: 60
linked author: Gladyshev, Vadim
linked information resource: Loss of epigenetic information as a cause of mammalian aging.

Authorship 1517157
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: How can aging be reversed? Exploring rejuvenation from a damage-based perspective.

Authorship 1516491
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor.

How can aging be reversed? Exploring rejuvenation from a damage-based perspective.
PubMed Identifier: 36619246
author list: Zhang B, Gladyshev VN
published in: Advanced genetics (Hoboken, N.J.)
information resource reference: How can aging be reversed? Exploring rejuvenation from a damage-based perspective. Adv Genet (Hoboken). 2020 Dec; 1(1):e10025.
journal title abbreviation: Adv Genet (Hoboken)
publication date: 2020-08-10T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of epigenetic information as a cause of mammalian aging.
PubMed Identifier: 36638792
author list: Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA
published in: Cell
information resource reference: Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 01 19; 186(2):305-326.e27.
journal title abbreviation: Cell
publication date: 2023-01-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor.
PubMed Identifier: 36670049
author list: Bennett DF, Goyala A, Statzer C, Beckett CW, Tyshkovskiy A, Gladyshev VN, Ewald CY, de Magalhães JP
published in: Aging cell
information resource reference: Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor. Aging Cell. 2023 02; 22(2):e13774.
journal title abbreviation: Aging Cell
publication date: 2023-01-20T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1519318
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning.

Authorship 1520183
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Metabolism, homeostasis, and aging.

Metabolism, homeostasis, and aging.
PubMed Identifier: 36681595
author list: Moldakozhayev A, Gladyshev VN
published in: Trends in endocrinology and metabolism: TEM
information resource reference: Metabolism, homeostasis, and aging. Trends Endocrinol Metab. 2023 03; 34(3):158-169.
journal title abbreviation: Trends Endocrinol Metab
publication date: 2023-01-20T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning.
PubMed Identifier: 32534441
author list: Galkin F, Mamoshina P, Aliper A, Lane E, Moskalev V, Gladyshev VN, Zhavoronkov A
published in: iScience
information resource reference: Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning. iScience. 2020 Jun 26; 23(6):101199.
journal title abbreviation: iScience
publication date: 2020-05-23T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
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Authorship 1527769
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.

Authorship 1527961
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Molecular Damage in Aging.

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.
PubMed Identifier: 32272169
author list: Galkin F, Mamoshina P, Aliper A, de Magalhães JP, Gladyshev VN, Zhavoronkov A
published in: Ageing research reviews
information resource reference: Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities. Ageing Res Rev. 2020 07; 60:101050.
journal title abbreviation: Ageing Res Rev
publication date: 2020-04-06T00:00:00
year: 2020
type: Academic Article
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Molecular Damage in Aging.
PubMed Identifier: 36846190
author list: Gladyshev VN, Kritchevsky SB, Clarke SG, Cuervo AM, Fiehn O, de Magalhães JP, Mau T, Maes M, Moritz R, Niedernhofer LJ, Van Schaftingen E, Tranah GJ, Walsh K, Yura Y, Zhang B, Cummings SR
published in: Nature aging
information resource reference: Molecular Damage in Aging. Nat Aging. 2021 12; 1(12):1096-1106.
journal title abbreviation: Nat Aging
publication date: 2021-12-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Biological age is increased by stress and restored upon recovery.
PubMed Identifier: 37086720
author list: Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN
published in: Cell metabolism
information resource reference: Biological age is increased by stress and restored upon recovery. Cell Metab. 2023 05 02; 35(5):807-820.e5.
journal title abbreviation: Cell Metab
publication date: 2023-04-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Goeminne, Ludger
eCommons Login: lug506
first name: Ludger
last name: Goeminne
full name: Ludger Jan E Goeminne, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 213075
person in primary position: Research Fellow in Medicine
type: Agent
type: Person
preferred title: Research Fellow in Medicine

Authorship 471273
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins.

Authorship 273823
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: The Plasmodium selenoproteome.

Authorship 1568759
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.

Authorship 1567755
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Mitigating age-related somatic mutation burden.

Authorship 1572408
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Accelerated transcriptional elongation during aging impairs longevity.

Authorship 1568484
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

Authorship 1566948
type: Authorship
author rank in publication: 18
linked author: Gladyshev, Vadim
linked information resource: Biological age is increased by stress and restored upon recovery.

Authorship 1566703
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations.

Authorship 1571110
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Multi-omic rejuvenation and life span extension on exposure to youthful circulation.

Authorship 1567372
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.

Authorship 1555301
type: Authorship
author rank in publication: 17
linked author: Gladyshev, Vadim
linked information resource: Chemically induced reprogramming to reverse cellular aging.

Authorship 1553068
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Distinct longevity mechanisms across and within species and their association with aging.

Distinct longevity mechanisms across and within species and their association with aging.
PubMed Identifier: 37269831
author list: Tyshkovskiy A, Ma S, Shindyapina AV, Tikhonov S, Lee SG, Bozaykut P, Castro JP, Seluanov A, Schork NJ, Gorbunova V, Dmitriev SE, Miller RA, Gladyshev VN
published in: Cell
information resource reference: Distinct longevity mechanisms across and within species and their association with aging. Cell. 2023 06 22; 186(13):2929-2949.e20.
journal title abbreviation: Cell
publication date: 2023-06-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.
PubMed Identifier: 37427458
author list: Liu W, Zhu P, Li M, Li Z, Yu Y, Liu G, Du J, Wang X, Yang J, Tian R, Seim I, Kaya A, Li M, Li M, Gladyshev VN, Zhou X
published in: The EMBO journal
information resource reference: Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals. EMBO J. 2023 09 04; 42(17):e112740.
journal title abbreviation: EMBO J
publication date: 2023-07-10T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Accelerated transcriptional elongation during aging impairs longevity.
PubMed Identifier: 37253838
author list: Tyshkovskiy A, Zhang S, Gladyshev VN
published in: Cell research
information resource reference: Accelerated transcriptional elongation during aging impairs longevity. Cell Res. 2023 11; 33(11):817-818.
journal title abbreviation: Cell Res
publication date: 2023-11-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations.
PubMed Identifier: 37386259
author list: Ogrodnik M, Gladyshev VN
published in: Nature aging
information resource reference: The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations. Nat Aging. 2023 07; 3(7):766-775.
journal title abbreviation: Nat Aging
publication date: 2023-06-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Multi-omic rejuvenation and life span extension on exposure to youthful circulation.
PubMed Identifier: 37500973
author list: Zhang B, Lee DE, Trapp A, Tyshkovskiy A, Lu AT, Bareja A, Kerepesi C, McKay LK, Shindyapina AV, Dmitriev SE, Baht GS, Horvath S, Gladyshev VN, White JP
published in: Nature aging
information resource reference: Multi-omic rejuvenation and life span extension on exposure to youthful circulation. Nat Aging. 2023 08; 3(8):948-964.
journal title abbreviation: Nat Aging
publication date: 2023-07-27T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
PubMed Identifier: 37425825
author list: Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation. bioRxiv. 2023 Nov 27.
journal title abbreviation: bioRxiv
publication date: 2023-11-27T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.
PubMed Identifier: 37118067
author list: Ribeiro R, Macedo JC, Costa M, Ustiyan V, Shindyapina AV, Tyshkovskiy A, Gomes RN, Castro JP, Kalin TV, Vasques-Nóvoa F, Nascimento DS, Dmitriev SE, Gladyshev VN, Kalinichenko VV, Logarinho E
published in: Nature aging
information resource reference: In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan. Nat Aging. 2022 05; 2(5):397-411.
journal title abbreviation: Nat Aging
publication date: 2022-05-05T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Chemically induced reprogramming to reverse cellular aging.
PubMed Identifier: 37437248
author list: Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA
published in: Aging
information resource reference: Chemically induced reprogramming to reverse cellular aging. Aging (Albany NY). 2023 07 12; 15(13):5966-5989.
journal title abbreviation: Aging (Albany NY)
publication date: 2023-07-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Mitigating age-related somatic mutation burden.
PubMed Identifier: 37121869
author list: Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K
published in: Trends in molecular medicine
information resource reference: Mitigating age-related somatic mutation burden. Trends Mol Med. 2023 07; 29(7):530-540.
journal title abbreviation: Trends Mol Med
publication date: 2023-04-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 225078
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2.

DNA methylation networks underlying mammalian traits.
PubMed Identifier: 37561875
author list: Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y,…
published in: Science (New York, N.Y.)
information resource reference: DNA methylation networks underlying mammalian traits. Science. 2023 08 11; 381(6658):eabq5693.
journal title abbreviation: Science
publication date: 2023-08-11T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Biomarkers of aging for the identification and evaluation of longevity interventions.
PubMed Identifier: 37657418
author list: Moqri M, Herzog C, Poganik JR, Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN
published in: Cell
information resource reference: Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 08 31; 186(18):3758-3775.
journal title abbreviation: Cell
publication date: 2023-08-31T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Universal DNA methylation age across mammalian tissues.
PubMed Identifier: 37563227
author list: Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG…
published in: Nature aging
information resource reference: Universal DNA methylation age across mammalian tissues. Nat Aging. 2023 09; 3(9):1144-1166.
journal title abbreviation: Nat Aging
publication date: 2023-08-10T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

We need to shift the focus of aging research to aging itself.
PubMed Identifier: 37682890
author list: Poganik JR, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: We need to shift the focus of aging research to aging itself. Proc Natl Acad Sci U S A. 2023 09 12; 120(37):e2307449120.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2023-09-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1590950
type: Authorship
author rank in publication: 28
linked author: Gladyshev, Vadim
linked information resource: Biomarkers of aging for the identification and evaluation of longevity interventions.

Authorship 1592317
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: 18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis.

Authorship 1584315
type: Authorship
author rank in publication: 56
linked author: Gladyshev, Vadim
linked information resource: Universal DNA methylation age across mammalian tissues.

Authorship 1591822
type: Authorship
author rank in publication: 56
linked author: Gladyshev, Vadim
linked information resource: Author Correction: Universal DNA methylation age across mammalian tissues.

Authorship 1592152
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: We need to shift the focus of aging research to aging itself.

Authorship 1585400
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.

Authorship 1584260
type: Authorship
author rank in publication: 57
linked author: Gladyshev, Vadim
linked information resource: DNA methylation networks underlying mammalian traits.

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.
PubMed Identifier: 37612507
author list: Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V
published in: Nature
information resource reference: Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice. Nature. 2023 09; 621(7977):196-205.
journal title abbreviation: Nature
publication date: 2023-08-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis.
PubMed Identifier: 37689068
author list: Liberman N, Rothi MH, Gerashchenko MV, Zorbas C, Boulias K, MacWhinnie FG, Ying AK, Flood Taylor A, Al Haddad J, Shibuya H, Roach L, Dong A, Dellacona S, Lafontaine DLJ, Gladyshev VN, Greer EL
published in: Molecular cell
information resource reference: 18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis. Mol Cell. 2023 09 21; 83(18):3268-3282.e7.
journal title abbreviation: Mol Cell
publication date: 2023-09-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Author Correction: Universal DNA methylation age across mammalian tissues.
PubMed Identifier: 37674040
author list: Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG…
published in: Nature aging
information resource reference: Author Correction: Universal DNA methylation age across mammalian tissues. Nat Aging. 2023 Nov; 3(11):1462.
journal title abbreviation: Nat Aging
publication date: 2023-11-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1594994
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Intersection clock reveals a rejuvenation event during human embryogenesis.

Intersection clock reveals a rejuvenation event during human embryogenesis.
PubMed Identifier: 37786333
author list: Kerepesi C, Gladyshev VN
published in: Aging cell
information resource reference: Intersection clock reveals a rejuvenation event during human embryogenesis. Aging Cell. 2023 10; 22(10):e13922.
journal title abbreviation: Aging Cell
publication date: 2023-10-02T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 419706
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.

Authorship 1598819
type: Authorship
author rank in publication: 18
linked author: Gladyshev, Vadim
linked information resource: OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records.
PubMed Identifier: 37904959
author list: Chen Q, Dwaraka VB, Carreras-Gallo N, Mendez K, Chen Y, Begum S, Kachroo P, Prince N, Went H, Mendez T, Lin A, Turner L, Moqri M, Chu SH, Kelly RS, Weiss ST, Rattray NJW, Gladyshev VN, Karlson E, Wheelock C, Mathé EA, Dahlin A, McGeachie MJ, Smith R, Lasky-Su JA
published in: bioRxiv : the preprint server for biology
information resource reference: OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records. bioRxiv. 2023 Oct 24.
journal title abbreviation: bioRxiv
publication date: 2023-10-24T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1609950
type: Authorship
author rank in publication: 27
linked author: Gladyshev, Vadim
linked information resource: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
PubMed Identifier: 37957361
author list: Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ
published in: Nature aging
information resource reference: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nat Aging. 2023 12; 3(12):1561-1575.
journal title abbreviation: Nat Aging
publication date: 2023-11-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1613363
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging.

Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging.
PubMed Identifier: 38066057
author list: Fernando R, Shindyapina AV, Ost M, Santesmasses D, Hu Y, Tyshkovskiy A, Yim SH, Weiss J, Gladyshev VN, Grune T, Castro JP
published in: Communications biology
information resource reference: Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging. Commun Biol. 2023 12 08; 6(1):1240.
journal title abbreviation: Commun Biol
publication date: 2023-12-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 511541
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy.

Authorship 528760
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions.

Authorship 1620424
type: Authorship
author rank in publication: 23
linked author: Gladyshev, Vadim
linked information resource: TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.

TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.
PubMed Identifier: 38200273
author list: Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, Carmody C, Vera DL, Kerepesi C, Ying K, Noren Hooten N, Mitchell JR, Evans MK, Gladyshev VN, Sinclair DA
published in: Nature aging
information resource reference: TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. Nat Aging. 2024 Feb; 4(2):261-274.
journal title abbreviation: Nat Aging
publication date: 2024-01-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1622000
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Causality-enriched epigenetic age uncouples damage and adaptation.

Causality-enriched epigenetic age uncouples damage and adaptation.
PubMed Identifier: 38243142
author list: Ying K, Liu H, Tarkhov AE, Sadler MC, Lu AT, Moqri M, Horvath S, Kutalik Z, Shen X, Gladyshev VN
published in: Nature aging
information resource reference: Causality-enriched epigenetic age uncouples damage and adaptation. Nat Aging. 2024 Feb; 4(2):231-246.
journal title abbreviation: Nat Aging
publication date: 2024-01-19T00:00:00
year: 2024
type: Academic Article
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Professor of Medicine
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position in department: Medicine
position in division: Genetics
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Validation of biomarkers of aging.
PubMed Identifier: 38355974
author list: Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hägg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L
published in: Nature medicine
information resource reference: Validation of biomarkers of aging. Nat Med. 2024 02; 30(2):360-372.
journal title abbreviation: Nat Med
publication date: 2024-02-14T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Moqri, Mahdi
first name: Mahdi
last name: Moqri
full name: Mahdi Moqri, Ph.D.
has faculty rank: Instructor
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person in primary position: Instructor in Medicine
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preferred title: Instructor in Medicine

Authorship 1629099
type: Authorship
author rank in publication: 60
linked author: Gladyshev, Vadim
linked information resource: Loss of epigenetic information as a cause of mammalian aging.

Authorship 1631418
type: Authorship
author rank in publication: 27
linked author: Gladyshev, Vadim
linked information resource: Validation of biomarkers of aging.

Loss of epigenetic information as a cause of mammalian aging.
PubMed Identifier: 38428398
author list: Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA
published in: Cell
information resource reference: Loss of epigenetic information as a cause of mammalian aging. Cell. 2024 Feb 29; 187(5):1312-1313.
journal title abbreviation: Cell
publication date: 2024-02-29T00:00:00
year: 2024
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type: Information Resource

Authorship 1634114
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: The long and winding road of reprogramming-induced rejuvenation.

The long and winding road of reprogramming-induced rejuvenation.
PubMed Identifier: 38431638
author list: Yücel AD, Gladyshev VN
published in: Nature communications
information resource reference: The long and winding road of reprogramming-induced rejuvenation. Nat Commun. 2024 Mar 02; 15(1):1941.
journal title abbreviation: Nat Commun
publication date: 2024-03-02T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 518997
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium.

Authorship 556263
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.

Authorship 1636149
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
PubMed Identifier: 38517750
author list: Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN
published in: eLife
information resource reference: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation. Elife. 2024 Mar 22; 12.
journal title abbreviation: Elife
publication date: 2024-03-22T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1642174
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.

Authorship 1641594
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Sendai virus persistence questions the transient naive reprogramming method for iPSC generation.

Authorship 1641411
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Selenium, diabetes, and their intricate sex-specific relationship.

A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.
PubMed Identifier: 38585858
author list: Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S
published in: bioRxiv : the preprint server for biology
information resource reference: A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan. bioRxiv. 2024 Mar 25.
journal title abbreviation: bioRxiv
publication date: 2024-03-25T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenium, diabetes, and their intricate sex-specific relationship.
PubMed Identifier: 38599899
author list: Demircan K, Chillon TS, Bang J, Gladyshev VN, Schomburg L
published in: Trends in endocrinology and metabolism: TEM
information resource reference: Selenium, diabetes, and their intricate sex-specific relationship. Trends Endocrinol Metab. 2024 09; 35(9):781-792.
journal title abbreviation: Trends Endocrinol Metab
publication date: 2024-04-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Sendai virus persistence questions the transient naive reprogramming method for iPSC generation.
PubMed Identifier: 38559172
author list: De Los Angeles A, Hug CB, Gladyshev VN, Church GM, Velychko S
published in: bioRxiv : the preprint server for biology
information resource reference: Sendai virus persistence questions the transient naive reprogramming method for iPSC generation. bioRxiv. 2024 Mar 12.
journal title abbreviation: bioRxiv
publication date: 2024-03-12T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 161914
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: A functional link between housekeeping selenoproteins and phase II enzymes.

Understanding Interorgan Communication Through Heterochronic Organ Transplantation
end date: 2029-02-28
principal investigator name: GLADYSHEV, VADIM N.
start date: 2024-06-01
type: Grant
sponsor award id: U01AG086168

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Understanding Interorgan Communication Through Heterochronic Organ Transplantation

Authorship 1654750
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation.

Authorship 1647231
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: A single cell atlas of the mouse seminal vesicle.

Authorship 1647558
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Nature of epigenetic aging from a single-cell perspective.

Authorship 1651167
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: AgeMeta: Quantitative Gene Expression Database of Mammalian Aging.

Authorship 1649487
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research.

Authorship 1653587
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.

Authorship 1649576
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: The beginning of becoming a human.

The beginning of becoming a human.
PubMed Identifier: 38713165
author list: Loseva PA, Gladyshev VN
published in: Aging
information resource reference: The beginning of becoming a human. Aging (Albany NY). 2024 05 06; 16(9):8378-8395.
journal title abbreviation: Aging (Albany NY)
publication date: 2024-05-06T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Nature of epigenetic aging from a single-cell perspective.
PubMed Identifier: 38724733
author list: Tarkhov AE, Lindstrom-Vautrin T, Zhang S, Ying K, Moqri M, Zhang B, Tyshkovskiy A, Levy O, Gladyshev VN
published in: Nature aging
information resource reference: Nature of epigenetic aging from a single-cell perspective. Nat Aging. 2024 Jun; 4(6):854-870.
journal title abbreviation: Nat Aging
publication date: 2024-05-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation.
PubMed Identifier: 38779483
author list: Barlit H, Romero AM, Gülhan A, Patnaik PK, Tyshkovskiy A, Martínez-Pastor MT, Gladyshev VN, Puig S, Labunskyy VM
published in: iScience
information resource reference: Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation. iScience. 2024 Jun 21; 27(6):109868.
journal title abbreviation: iScience
publication date: 2024-04-30T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research.
PubMed Identifier: 38712089
author list: Gujjala VA, Klimek I, Abyadeh M, Tyshkovskiy A, Oz N, Castro JP, Gladyshev VN, Newton J, Kaya A
published in: bioRxiv : the preprint server for biology
information resource reference: A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research. bioRxiv. 2024 May 13.
journal title abbreviation: bioRxiv
publication date: 2024-05-13T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

A single cell atlas of the mouse seminal vesicle.
PubMed Identifier: 38645090
author list: Sun F, Desevin K, Fu Y, Parameswaran S, Mayall J, Rinaldi V, Krietenstein N, Manukyan A, Yin Q, Galan C, Yang CH, Shindyapina AV, Gladyshev VN, Garber M, Schjenken JE, Rando OJ
published in: bioRxiv : the preprint server for biology
information resource reference: A single cell atlas of the mouse seminal vesicle. bioRxiv. 2024 Apr 11.
journal title abbreviation: bioRxiv
publication date: 2024-04-11T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

AgeMeta: Quantitative Gene Expression Database of Mammalian Aging.
PubMed Identifier: 38622098
author list: Tikhonov S, Batin M, Gladyshev VN, Dmitriev SE, Tyshkovskiy A
published in: Biochemistry. Biokhimiia
information resource reference: AgeMeta: Quantitative Gene Expression Database of Mammalian Aging. Biochemistry (Mosc). 2024 Feb; 89(2):313-321.
journal title abbreviation: Biochemistry (Mosc)
publication date: 2024-02-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.
PubMed Identifier: 38798397
author list: Hafiz Rothi M, Sarkar GC, Haddad JA, Mitchell W, Ying K, Pohl N, Sotomayor-Mena RG, Natale J, Dellacono S, Gladyshev VN, Lieberman Greer E
published in: bioRxiv : the preprint server for biology
information resource reference: The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life. bioRxiv. 2024 May 15.
journal title abbreviation: bioRxiv
publication date: 2024-05-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1657038
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Epigenetic predictors of species maximum life span and other life-history traits in mammals.

Epigenetic predictors of species maximum life span and other life-history traits in mammals.
PubMed Identifier: 38848365
author list: Li CZ, Haghani A, Yan Q, Lu AT, Zhang J, Fei Z, Ernst J, Yang XW, Gladyshev VN, Robeck TR, Chavez AS, Cook JA, Dunnum JL, Raj K, Seluanov A, Gorbunova V, Horvath S
published in: Science advances
information resource reference: Epigenetic predictors of species maximum life span and other life-history traits in mammals. Sci Adv. 2024 06 07; 10(23):eadm7273.
journal title abbreviation: Sci Adv
publication date: 2024-06-07T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
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Authorship 1663591
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.

The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.
PubMed Identifier: 38946979
author list: Rothi MH, Haddad JA, Sarkar GC, Mitchell W, Ying K, Pohl N, Sotomayor R, Natale J, Dellacono S, Gladyshev VN, Greer EL
published in: Research square
information resource reference: The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life. Res Sq. 2024 Jun 21.
journal title abbreviation: Res Sq
publication date: 2024-06-21T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 399903
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals.

Authorship 1666919
type: Authorship
author rank in publication: 16
linked author: Gladyshev, Vadim
linked information resource: PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.

PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.
PubMed Identifier: 39009581
author list: Moqri M, Cipriano A, Simpson DJ, Rasouli S, Murty T, de Jong TA, Nachun D, de Sena Brandine G, Ying K, Tarkhov A, Aberg KA, van den Oord E, Zhou W, Smith A, Mackall C, Gladyshev VN, Horvath S, Snyder MP, Sebastiano V
published in: Nature communications
information resource reference: PRC2-AgeIndex as a universal biomarker of aging and rejuvenation. Nat Commun. 2024 Jul 16; 15(1):5956.
journal title abbreviation: Nat Commun
publication date: 2024-07-16T00:00:00
year: 2024
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Authorship 238799
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: ¹H, ¹³C, and ¹5N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR.

Robert Winthrop Professor of Genetics
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position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Robert Winthrop Professor of Genetics
position in organization: Harvard Medical School

Associate Professor of Medicine
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position in department: Medicine
position in division: Genetics
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Instructor in Medicine
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position in department: Medicine
position in division: Genetics
sort order: 1
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HR job title: Instructor in Medicine
position in organization: Harvard Medical School

Authorship 45214
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase.

Authorship 461420
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.

Authorship 469368
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Selenoproteins that function in cancer prevention and promotion.

Authorship 1679028
type: Authorship
author rank in publication: 22
linked author: Gladyshev, Vadim
linked information resource: Age-associated clonal B cells drive B cell lymphoma in mice.

Age-associated clonal B cells drive B cell lymphoma in mice.
PubMed Identifier: 39117982
author list: Castro JP, Shindyapina AV, Barbieri A, Ying K, Strelkova OS, Paulo JA, Tyshkovskiy A, Meinl R, Kerepesi C, Petrashen AP, Mariotti M, Meer MV, Hu Y, Karamyshev A, Losyev G, Galhardo M, Logarinho E, Indzhykulian AA, Gygi SP, Sedivy JM, Manis JP, Gladyshev VN
published in: Nature aging
information resource reference: Age-associated clonal B cells drive B cell lymphoma in mice. Nat Aging. 2024 Oct; 4(10):1403-1417.
journal title abbreviation: Nat Aging
publication date: 2024-08-08T00:00:00
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type: Document
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Authorship 250714
type: Authorship
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linked author: Gladyshev, Vadim
linked information resource: Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression.

Authorship 263071
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan.

Authorship 1687690
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.

Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.
PubMed Identifier: 39178313
author list: Du J, Liu W, Li M, Li Z, Li X, Dai Y, Liu G, Wang X, Zhu P, Gladyshev VN, Zhou X
published in: PLoS biology
information resource reference: Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance. PLoS Biol. 2024 Aug; 22(8):e3002778.
journal title abbreviation: PLoS Biol
publication date: 2024-08-23T00:00:00
year: 2024
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type: Document
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Authorship 491914
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Authorship 660355
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins.

Authorship 668358
type: Authorship
author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

Authorship 647545
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Comparative genomics analysis of the metallomes.

Authorship 667511
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide.

Authorship 643145
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.

Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.
PubMed Identifier: 23389288
author list: Kasaikina MV, Turanov AA, Avanesov A, Schweizer U, Seeher S, Bronson RT, Novoselov SN, Carlson BA, Hatfield DL, Gladyshev VN
published in: Carcinogenesis
information resource reference: Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis. Carcinogenesis. 2013 May; 34(5):1089-95.
journal title abbreviation: Carcinogenesis
publication date: 2013-02-06T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.
PubMed Identifier: 23911929
author list: Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN
published in: Molecular cell
information resource reference: MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013 Aug 08; 51(3):397-404.
journal title abbreviation: Mol Cell
publication date: 2013-08-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin.
PubMed Identifier: 23589299
author list: Tobe R, Naranjo-Suarez S, Everley RA, Carlson BA, Turanov AA, Tsuji PA, Yoo MH, Gygi SP, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. J Biol Chem. 2013 May 24; 288(21):14709-15.
journal title abbreviation: J Biol Chem
publication date: 2013-04-15T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens.
PubMed Identifier: 23466703
author list: Gobler CJ, Lobanov AV, Tang YZ, Turanov AA, Zhang Y, Doblin M, Taylor GT, Sañudo-Wilhelmy SA, Grigoriev IV, Gladyshev VN
published in: The ISME journal
information resource reference: The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens. ISME J. 2013 Jul; 7(7):1333-43.
journal title abbreviation: ISME J
publication date: 2013-03-07T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomics analysis of the metallomes.
PubMed Identifier: 23595683
author list: Gladyshev VN, Zhang Y
published in: Metal ions in life sciences
information resource reference: Comparative genomics analysis of the metallomes. Met Ions Life Sci. 2013; 12:529-80.
journal title abbreviation: Met Ions Life Sci
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins.
PubMed Identifier: 23716634
author list: Turanov AA, Lobanov AV, Hatfield DL, Gladyshev VN
published in: Nucleic acids research
information resource reference: UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins. Nucleic Acids Res. 2013 Aug; 41(14):6952-9.
journal title abbreviation: Nucleic Acids Res
publication date: 2013-05-28T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide.
PubMed Identifier: 23776515
author list: Le DT, Tarrago L, Watanabe Y, Kaya A, Lee BC, Tran U, Nishiyama R, Fomenko DE, Gladyshev VN, Tran LS
published in: PloS one
information resource reference: Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. PLoS One. 2013; 8(6):e65637.
journal title abbreviation: PLoS One
publication date: 2013-06-12T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1701845
type: Authorship
author rank in publication: 35
linked author: Gladyshev, Vadim
linked information resource: Challenges and recommendations for the translation of biomarkers of aging.

Authorship 1694331
type: Authorship
author rank in publication: 115
linked author: Gladyshev, Vadim
linked information resource: Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

Authorship 1695508
type: Authorship
author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: High-dimensional Ageome Representations of Biological Aging across Functional Modules.

Authorship 1699189
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.

Challenges and recommendations for the translation of biomarkers of aging.
PubMed Identifier: 39285015
author list: Herzog CMS, Goeminne LJE, Poganik JR, Barzilai N, Belsky DW, Betts-LaCroix J, Chen BH, Chen M, Cohen AA, Cummings SR, Fedichev PO, Ferrucci L, Fleming A, Fortney K, Furman D, Gorbunova V, Higgins-Chen A, Hood L, Horvath S, Justice JN, Kiel DP, Kuchel GA, Lasky-Su J, LeBrasseur NK, Maier AB, Schilling B, Sebastiano V, Slagboom PE, Snyder MP, Verdin E, Widschwendter M, Zhavoronkov A, Moqri M, Gladyshev VN
published in: Nature aging
information resource reference: Challenges and recommendations for the translation of biomarkers of aging. Nat Aging. 2024 Oct; 4(10):1372-1383.
journal title abbreviation: Nat Aging
publication date: 2024-09-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

High-dimensional Ageome Representations of Biological Aging across Functional Modules.
PubMed Identifier: 39345525
author list: Ying K, Tyshkovskiy A, Chen Q, Latorre-Crespo E, Zhang B, Liu H, Matei-Dediu B, Poganik JR, Moqri M, Kirschne K, Lasky-Su J, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: High-dimensional Ageome Representations of Biological Aging across Functional Modules. bioRxiv. 2024 Sep 21.
journal title abbreviation: bioRxiv
publication date: 2024-09-21T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.
PubMed Identifier: 39418098
author list: Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Soldacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, Dimmeler S, Rando TA, Peterson TR, Woods T, Wyss-Coray T, Finkel T, Strauss T, Gladyshev VN, Longo VD, Dwaraka VB, Gorbunova V, Acosta-Rodríguez VA, Sorrentino V, Sebastiano V, Li W, Suh Y, Zhavoronkov A, Scheibye-Knudsen M, Bakula D
published in: Aging
information resource reference: Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024 10 16; 16(20):12955-12976.
journal title abbreviation: Aging (Albany NY)
publication date: 2024-10-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.
PubMed Identifier: 39424787
author list: Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN
published in: Nature communications
information resource reference: Depletion of loss-of-function germline mutations in centenarians reveals longevity genes. Nat Commun. 2024 10 19; 15(1):9030.
journal title abbreviation: Nat Commun
publication date: 2024-10-19T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Research Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Genetics
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HR job title: Research Fellow in Medicine
position in organization: Brigham and Women's Hospital

Jacques, Erik
first name: Erik
last name: Jacques
full name: Erik Jacques, Ph.D.
has faculty rank: Fellow or Post Doc
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person in primary position: Research Fellow in Medicine
type: Agent
type: Person
preferred title: Research Fellow in Medicine

Authorship 1708944
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linked author: Gladyshev, Vadim
linked information resource: DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.

Authorship 1707202
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.

Authorship 1705206
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems.

Authorship 1707207
type: Authorship
author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: An Open Competition for Biomarkers of Aging.

Authorship 1708940
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author rank in publication: 14
linked author: Gladyshev, Vadim
linked information resource: MethylGPT: a foundation model for the DNA methylome.

Authorship 1708498
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author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors.

An Open Competition for Biomarkers of Aging.
PubMed Identifier: 39554132
author list: Ying K, Paulson S, Reinhard J, de Lima Camillo LP, Träuble J, Jokiel S, Gobel D, Herzog C, Poganik JR, Moqri M, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: An Open Competition for Biomarkers of Aging. bioRxiv. 2024 Nov 03.
journal title abbreviation: bioRxiv
publication date: 2024-11-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
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DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.
PubMed Identifier: 39574710
author list: Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov A, Sun S, Wu Z, Gigas J, Hillpot E, Martinez J, Lee M, Williams A, Gilman A, Hamilton N, Haseljic E, Patel A, Straight M, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopman M, Moritz R, Fujii S, Hayman DJ, Liu H, Cai Y, Leung AKL, Simons MJP, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Modesti M, Genovese G, Vijg J, Seluanov A, Gorbunova V
published in: bioRxiv : the preprint server for biology
information resource reference: DNA repair and anti-cancer mechanisms in the long-lived bowhead whale. bioRxiv. 2024 Nov 05.
journal title abbreviation: bioRxiv
publication date: 2024-11-05T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors.
PubMed Identifier: 39594490
author list: Shim HB, Lee H, Cho HY, Jo YH, Tarrago L, Kim H, Gladyshev VN, Lee BC
published in: Antioxidants (Basel, Switzerland)
information resource reference: Development and Optimization of a Redox Enzyme-Based Fluorescence Biosensor for the Identification of MsrB1 Inhibitors. Antioxidants (Basel). 2024 Nov 02; 13(11).
journal title abbreviation: Antioxidants (Basel)
publication date: 2024-11-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems.
PubMed Identifier: 39488213
author list: Goeminne LJE, Vladimirova A, Eames A, Tyshkovskiy A, Argentieri MA, Ying K, Moqri M, Gladyshev VN
published in: Cell metabolism
information resource reference: Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems. Cell Metab. 2025 Jan 07; 37(1):205-222.e6.
journal title abbreviation: Cell Metab
publication date: 2024-11-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

MethylGPT: a foundation model for the DNA methylome.
PubMed Identifier: 39574641
author list: Ying K, Song J, Cui H, Zhang Y, Li S, Chen X, Liu H, Eames A, McCartney DL, Marioni RE, Poganik JR, Moqri M, Wang B, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: MethylGPT: a foundation model for the DNA methylome. bioRxiv. 2024 Nov 04.
journal title abbreviation: bioRxiv
publication date: 2024-11-04T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.
PubMed Identifier: 39554099
author list: Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek DJ, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age. bioRxiv. 2024 Oct 31.
journal title abbreviation: bioRxiv
publication date: 2024-10-31T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 507148
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.

Authorship 522072
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Comparison of selenium-containing molybdoenzymes.

Authorship 554583
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development.

Authorship 18666
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds.

Disagreement on foundational principles of biological aging.
PubMed Identifier: 39660064
author list: Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A
published in: PNAS nexus
information resource reference: Disagreement on foundational principles of biological aging. PNAS Nexus. 2024 Dec; 3(12):pgae499.
journal title abbreviation: PNAS Nexus
publication date: 2024-12-03T00:00:00
year: 2024
type: Academic Article
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type: Document
type: Information Resource

Balancing the promise and risks of geroscience interventions.
PubMed Identifier: 39753893
author list: Cohen AA, Beard JR, Ferrucci L, Fülöp T, Gladyshev VN, Moqri M, Olde Rikkert MGM, Picard M
published in: Nature aging
information resource reference: Balancing the promise and risks of geroscience interventions. Nat Aging. 2025 Jan; 5(1):4-8.
journal title abbreviation: Nat Aging
publication date: 2025-01-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1717479
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Balancing the promise and risks of geroscience interventions.

Authorship 1715597
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author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Disagreement on foundational principles of biological aging.

Authorship 239510
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: The roles of thiol oxidoreductases in yeast replicative aging.

Authorship 673951
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins.

Authorship 677825
type: Authorship
author rank in publication: 29
linked author: Gladyshev, Vadim
linked information resource: Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.

Authorship 674552
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan.

The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan.
PubMed Identifier: 23769208
author list: Gladyshev VN
published in: Trends in genetics : TIG
information resource reference: The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 2013 Sep; 29(9):506-12.
journal title abbreviation: Trends Genet
publication date: 2013-06-13T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins.
PubMed Identifier: 23783574
author list: Mariotti M, Lobanov AV, Guigo R, Gladyshev VN
published in: Nucleic acids research
information resource reference: SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins. Nucleic Acids Res. 2013 Aug; 41(15):e149.
journal title abbreviation: Nucleic Acids Res
publication date: 2013-06-19T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.
PubMed Identifier: 23962925
author list: Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN
published in: Nature communications
information resource reference: Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nat Commun. 2013; 4:2212.
journal title abbreviation: Nat Commun
publication date: 2013-01-01T00:00:00
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type: Academic Article
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type: Document
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Authorship 250817
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Semisynthesis and characterization of mammalian thioredoxin reductase.

Office of the Dean
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Authorship 679371
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Role of reactive oxygen species-mediated signaling in aging.

Role of reactive oxygen species-mediated signaling in aging.
PubMed Identifier: 22901002
author list: Labunskyy VM, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2013 Oct 20; 19(12):1362-72.
journal title abbreviation: Antioxid Redox Signal
publication date: 2012-09-20T00:00:00
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type: Academic Article
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Authorship 682597
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.

Authorship 690066
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens.

Authorship 690316
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Abrogated thioredoxin system causes increased sensitivity to TNF-a-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.

Authorship 684965
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.

Authorship 687158
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin reductase status.

Authorship 685457
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.

Authorship 687712
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase.

Authorship 686896
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin.

Abrogated thioredoxin system causes increased sensitivity to TNF-a-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.
PubMed Identifier: 24039713
author list: Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL
published in: PloS one
information resource reference: Abrogated thioredoxin system causes increased sensitivity to TNF-a-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus. PLoS One. 2013; 8(9):e71427.
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publication date: 2013-09-06T00:00:00
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type: Academic Article
type: Article
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Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin reductase status.
PubMed Identifier: 23912593
author list: Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL
published in: Molecules and cells
information resource reference: Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin reductase status. Mol Cells. 2013 Aug; 36(2):151-7.
journal title abbreviation: Mol Cells
publication date: 2013-08-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase.
PubMed Identifier: 23300818
author list: Dobrovolska O, Shumilina E, Gladyshev VN, Dikiy A
published in: PloS one
information resource reference: Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. PLoS One. 2012; 7(12):e52914.
journal title abbreviation: PLoS One
publication date: 2012-12-26T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.
PubMed Identifier: 18174224
author list: Castellano S, Gladyshev VN, Guigó R, Berry MJ
published in: Nucleic acids research
information resource reference: SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic Acids Res. 2008 Jan; 36(Database issue):D332-8.
journal title abbreviation: Nucleic Acids Res
publication date: 2008-01-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
PubMed Identifier: 9521673
author list: Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
published in: Biochemistry
information resource reference: Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Biochemistry. 1998 Mar 10; 37(10):3518-28.
journal title abbreviation: Biochemistry
publication date: 1998-03-10T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
PubMed Identifier: 22909029
author list: Williams DL, Bonilla M, Gladyshev VN, Salinas G
published in: Antioxidants & redox signaling
information resource reference: Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45.
journal title abbreviation: Antioxid Redox Signal
publication date: 2012-10-03T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 337214
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Genetic code supports targeted insertion of two amino acids by one codon.

Authorship 1734259
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative.

Authorship 1734633
type: Authorship
author rank in publication: 51
linked author: Gladyshev, Vadim
linked information resource: Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.

Authorship 1736354
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: What makes biological age epigenetic clocks tick.

Authorship 1730780
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: How to measure biological aging in humans.

Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative.
PubMed Identifier: 39915640
author list: Tanaka T, Sierra F, Gladyshev VN, Wyss-Coray T, Cuervo AM, Perez V, Ferrucci L
published in: Nature aging
information resource reference: Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative. Nat Aging. 2025 Feb; 5(2):188-192.
journal title abbreviation: Nat Aging
publication date: 2025-02-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.
PubMed Identifier: 39932386
author list: Rogina B, Anderson R, LeBrasseur NK, Curran SP, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean DC, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Raimundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N
published in: The journals of gerontology. Series A, Biological sciences and medical sciences
information resource reference: Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. J Gerontol A Biol Sci Med Sci. 2025 04 07; 80(5).
journal title abbreviation: J Gerontol A Biol Sci Med Sci
publication date: 2025-04-07T00:00:00
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type: Academic Article
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type: Information Resource

What makes biological age epigenetic clocks tick.
PubMed Identifier: 39994479
author list: Moqri M, Poganik JR, Horvath S, Gladyshev VN
published in: Nature aging
information resource reference: What makes biological age epigenetic clocks tick. Nat Aging. 2025 Mar; 5(3):335-336.
journal title abbreviation: Nat Aging
publication date: 2025-03-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

How to measure biological aging in humans.
PubMed Identifier: 40011691
author list: Ferrucci L, Barzilai N, Belsky DW, Gladyshev VN
published in: Nature medicine
information resource reference: How to measure biological aging in humans. Nat Med. 2025 Apr; 31(4):1057.
journal title abbreviation: Nat Med
publication date: 2025-04-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
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position in division: Genetics
sort order: 1
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HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 204911
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.

Research Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Genetics
sort order: 1
type: Position
HR job title: Research Fellow in Medicine
position in organization: Harvard Medical School

Authorship 1738481
type: Authorship
author rank in publication: 46
linked author: Gladyshev, Vadim
linked information resource: Invigorating discovery and clinical translation of aging biomarkers.

Authorship 1740251
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: A single cell atlas of the mouse seminal vesicle.

Authorship 1744208
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan.

Authorship 1744522
type: Authorship
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linked author: Gladyshev, Vadim
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Authorship 1745368
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Authorship 1747201
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linked information resource: The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.

Authorship 1747555
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linked information resource: Replacement as an aging intervention.

Authorship 1750619
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linked information resource: From geroscience to precision geromedicine: Understanding and managing aging.

Short-lived Niemann-Pick type C mice with accelerated brain aging as a novel model for Alzheimer's disease research.
PubMed Identifier: 40313113
author list: Gujjala VA, Abyadeh M, Klimek I, Tyshkovskiy A, Oz N, Castro JP, Gladyshev VN, Newton J, Kaya A
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Invigorating discovery and clinical translation of aging biomarkers.
PubMed Identifier: 40164770
author list: Jacques E, Herzog C, Ying K, Tomusiak A, Kasamoto J, Sehgal R, Paulson S, Reinhard J, Träuble J, Hastings WJ, Tyshkovskiy A, Hägg S, Earls JC, Behrens CE, Lasky-Su J, Zhou G, Morgen E, Tsang JS, Marioni RE, Ma XJ, Stolzing A, Glorioso C, Gootenberg JS, Abudayyeh OO, Argentieri MA, Mak RH, Cox LS, Brack AS, Lauc G, Furman D, Buenrostro JD, Schumacher B, Justice JN, Woods T, Gobel D, Perez VI, Sinclair DA, Maier AB, Barzilai N, Snyder MP, Wyss-Coray T, Horvath S, Ferrucci L, Poganik JR, Moqri M, Gladyshev VN
published in: Nature aging
information resource reference: Invigorating discovery and clinical translation of aging biomarkers. Nat Aging. 2025 Apr; 5(4):539-543.
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From geroscience to precision geromedicine: Understanding and managing aging.
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information resource reference: From geroscience to precision geromedicine: Understanding and managing aging. Cell. 2025 Apr 17; 188(8):2043-2062.
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Replacement as an aging intervention.
PubMed Identifier: 40341243
author list: Lore S, Poganik JR, Atala A, Church G, Gladyshev VN, Scheibye-Knudsen M, Verdin E
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A single cell atlas of the mouse seminal vesicle.
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author list: Sun F, Desevin K, Fu Y, Parameswaran S, Mayall J, Rinaldi V, Krietenstein N, Manukyan A, Yin Q, Galan C, Yang CH, Shindyapina AV, Gladyshev VN, Garber M, Schjenken JE, Rando OJ
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A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan.
PubMed Identifier: 40055478
author list: Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S
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information resource reference: A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan. Nat Aging. 2025 Mar; 5(3):437-449.
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Regeneration leads to global tissue rejuvenation in aging sexual planarians.
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The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.
PubMed Identifier: 40080911
author list: Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek DJ, Gladyshev VN
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information resource reference: The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age. Aging Cell. 2025 Jun; 24(6):e70026.
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James Stillman Professor of Developmental Biology
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HR job title: James Stillman Professor of Developmental Biology
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Authorship 700423
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linked author: Gladyshev, Vadim
linked information resource: SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.

SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.
PubMed Identifier: 24194593
author list: Romagné F, Santesmasses D, White L, Sarangi GK, Mariotti M, Hübler R, Weihmann A, Parra G, Gladyshev VN, Guigó R, Castellano S
published in: Nucleic acids research
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Authorship 702153
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linked author: Gladyshev, Vadim
linked information resource: Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.
PubMed Identifier: 24391512
author list: Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN
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information resource reference: Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019.
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Authorship 705189
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linked information resource: The free radical theory of aging is dead. Long live the damage theory!

The free radical theory of aging is dead. Long live the damage theory!
PubMed Identifier: 24159899
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Authorship 411827
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linked author: Gladyshev, Vadim
linked information resource: Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.

Authorship 194379
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linked author: Gladyshev, Vadim
linked information resource: Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.

Authorship 333602
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linked author: Gladyshev, Vadim
linked information resource: The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme.

Authorship 723148
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linked information resource: Selenium and selenocysteine: roles in cancer, health, and development.

Authorship 718998
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linked author: Gladyshev, Vadim
linked information resource: Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status.

Authorship 718682
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism.

Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism.
PubMed Identifier: 24522796
author list: Malinouski M, Hasan NM, Zhang Y, Seravalli J, Lin J, Avanesov A, Lutsenko S, Gladyshev VN
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Selenium and selenocysteine: roles in cancer, health, and development.
PubMed Identifier: 24485058
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Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status.
PubMed Identifier: 24710037
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information resource reference: Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status. Nat Commun. 2014 Apr 07; 5:3592.
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Instructor in Medicine
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Authorship 248290
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linked information resource: Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli.

The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium.
PubMed Identifier: 41466363
author list: de Magalhães CG, Moldakozhayev A, Lopez MV, Bowman GL, Chhatwal JP, Kellis M, Mohs R, Nisenbaum L, Quiroz YT, Raju RM, Sperling RA, Moqri M, Gladyshev VN
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information resource reference: The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium. Aging Cell. 2026 Jan; 25(1):e70351.
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Authorship 269014
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linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.

Authorship 275280
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases.

Profiling Epigenetic Aging at Cell-Type Resolution Through Long-Read Sequencing.
PubMed Identifier: 40599132
author list: Eames A, Moqri M, Poganik JR, Gladyshev VN
published in: Aging cell
information resource reference: Profiling Epigenetic Aging at Cell-Type Resolution Through Long-Read Sequencing. Aging Cell. 2025 Aug; 24(8):e70084.
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Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles.
PubMed Identifier: 41332661
author list: Ying K, Tyshkovskiy A, Moldakozhayev A, Wang H, De Magalhães CG, Iqbal S, Garza AE, Tskhay A, Poganik JR, Huang K, Qu Y, Glubokov D, Jin C, Lee D, Liu H, Leote C, Trapp A, de Lima Camillo LP, Kerepesi C, Moqri M, Zhang O, Jiang K, Galkin F, Zhavoronkov A, Van Raamsdonk JM, Wang M, Cong L, Regev A, Leskovec J, Wyss-Coray T, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles. bioRxiv. 2025 Nov 22.
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An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.
PubMed Identifier: 41402269
author list: Mavrommatis C, Belsky DW, Ying K, Moqri M, Campbell A, Richmond A, Gladyshev VN, Chandra T, McCartney DL, Marioni RE
published in: Nature communications
information resource reference: An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes. Nat Commun. 2025 Dec 16; 16(1):11164.
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Integrative epigenetics and transcriptomics identify aging genes in human blood.
PubMed Identifier: 41554691
author list: Moqri M, Ying K, Poganik JR, Herzog C, Chen Q, Emamifar M, Tyshkovskiy A, Eames A, Mur J, Glubokov D, Matei-Dediu B, Goeminne L, Mitchell W, McCartney DL, Salas LA, Marioni RE, Lasky-Su JA, Snyder MP, Gladyshev VN
published in: Nature communications
information resource reference: Integrative epigenetics and transcriptomics identify aging genes in human blood. Nat Commun. 2026 Jan 19; 17(1):725.
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Biomarkers of Aging-NIA Joint Symposium 2024: New Insights Into Aging Biomarkers.
PubMed Identifier: 40525821
author list: Herzog C, Poganik JR, Barzilai N, Basisty N, Beerman I, Belsky DW, de Cabo R, Candia J, Faghri F, Horvath S, Maier AB, Perez V, Sen P, Moqri M, Gladyshev VN, Ferrucci L
published in: Aging cell
information resource reference: Biomarkers of Aging-NIA Joint Symposium 2024: New Insights Into Aging Biomarkers. Aging Cell. 2025 Jul; 24(7):e70124.
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Authorship 726894
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linked author: Gladyshev, Vadim
linked information resource: Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein.

Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein.
PubMed Identifier: 24751718
author list: Han SJ, Lee BC, Yim SH, Gladyshev VN, Lee SR
published in: PloS one
information resource reference: Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. PLoS One. 2014; 9(4):e95518.
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An unbiased comparison of 14 epigenetic clocks in relation to 10-year onset of 174 disease outcomes in 18,859 individuals.
PubMed Identifier: 40791724
author list: Mavrommatis C, Belsky DW, Ying K, Moqri M, Campbell A, Richmond A, Gladyshev VN, Chandra T, McCartney DL, Marioni RE
published in: medRxiv : the preprint server for health sciences
information resource reference: An unbiased comparison of 14 epigenetic clocks in relation to 10-year onset of 174 disease outcomes in 18,859 individuals. medRxiv. 2025 Jul 15.
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A unified framework for systematic curation and evaluation of aging biomarkers.
PubMed Identifier: 41188602
author list: Ying K, Paulson S, Eames A, Tyshkovskiy A, Li S, Eynon N, Jacques M, Grolaux R, Seale K, Jacques E, Goeminne LJE, Cipriano A, Perez-Guevara M, Emamifar M, Casas Martínez M, Kwon D, Kosheleva A, Snyder M, Gobel D, Herzog C, McCartney DL, Marioni RE, Lasky-Su J, Poganik JR, Moqri M, Gladyshev VN
published in: Nature aging
information resource reference: A unified framework for systematic curation and evaluation of aging biomarkers. Nat Aging. 2025 Nov; 5(11):2323-2339.
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Authorship 307093
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linked author: Gladyshev, Vadim
linked information resource: Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase.

Authorship 729718
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linked author: Gladyshev, Vadim
linked information resource: Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.

Authorship 729034
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linked author: Gladyshev, Vadim
linked information resource: The first international mini-symposium on methionine restriction and lifespan.

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.
PubMed Identifier: 24843015
author list: Avanesov AS, Ma S, Pierce KA, Yim SH, Lee BC, Clish CB, Gladyshev VN
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information resource reference: Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife. 2014 Apr 29; 3:e02077.
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The first international mini-symposium on methionine restriction and lifespan.
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published in: Frontiers in genetics
information resource reference: The first international mini-symposium on methionine restriction and lifespan. Front Genet. 2014; 5:122.
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Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
PubMed Identifier: 24897171
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Authorship 1771533
type: Authorship
author rank in publication: 31
linked author: Gladyshev, Vadim
linked information resource: Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles.

Authorship 1774808
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linked author: Gladyshev, Vadim
linked information resource: An unbiased comparison of 14 epigenetic clocks in relation to 10-year onset of 174 disease outcomes in 18,859 individuals.

Authorship 1777577
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linked information resource: Biomarkers of Aging-NIA Joint Symposium 2024: New Insights Into Aging Biomarkers.

Authorship 1779075
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linked author: Gladyshev, Vadim
linked information resource: An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.

Authorship 1779153
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linked author: Gladyshev, Vadim
linked information resource: Profiling Epigenetic Aging at Cell-Type Resolution Through Long-Read Sequencing.

Authorship 1779746
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linked author: Gladyshev, Vadim
linked information resource: The Right Person, the Right Treatment, at the Right Time in Alzheimer's Disease: Insights From the 2025 Brain Aging Symposium.

Authorship 1780166
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linked author: Gladyshev, Vadim
linked information resource: A unified framework for systematic curation and evaluation of aging biomarkers.

Authorship 1784992
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linked author: Gladyshev, Vadim
linked information resource: Integrative epigenetics and transcriptomics identify aging genes in human blood.

Authorship 735766
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linked author: Gladyshev, Vadim
linked information resource: Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage.

Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage.
PubMed Identifier: 24817701
author list: Otero L, Romanelli-Cedrez L, Turanov AA, Gladyshev VN, Miranda-Vizuete A, Salinas G
published in: RNA (New York, N.Y.)
information resource reference: Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage. RNA. 2014 Jul; 20(7):1023-34.
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Authorship 1786328
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linked author: Gladyshev, Vadim
linked information resource: Novel metabolism in Chlamydomonas through the lens of genomics.

Authorship 1809250
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linked author: Gladyshev, Vadim
linked information resource: Skin health and biological aging.

Authorship 1813148
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author rank in publication: 17
linked author: Gladyshev, Vadim
linked information resource: Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.

Authorship 1814357
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linked author: Gladyshev, Vadim
linked information resource: In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation.

Authorship 1815203
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linked author: Gladyshev, Vadim
linked information resource: The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life.

Authorship 1817294
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linked author: Gladyshev, Vadim
linked information resource: Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale.

Authorship 1824714
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linked author: Gladyshev, Vadim
linked information resource: In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation.

Authorship 1834928
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linked author: Gladyshev, Vadim
linked information resource: Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model.

Authorship 1834397
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linked author: Gladyshev, Vadim
linked information resource: OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.

Authorship 1846863
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author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: MSRB3 antioxidant activity is necessary for inner ear cuticular plate structure and hair bundle integrity.

Authorship 1847946
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.

Authorship 1847986
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linked author: Gladyshev, Vadim
linked information resource: Network-driven discovery of repurposable drugs targeting hallmarks of aging.

Authorship 1848037
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author rank in publication: 24
linked author: Gladyshev, Vadim
linked information resource: Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.

Authorship 1849721
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author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures.

Authorship 1852766
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linked author: Gladyshev, Vadim
linked information resource: Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations.

Authorship 1850237
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: A National Institute on Aging workshop on the long-term effects of pregnancy on aging.

Novel metabolism in Chlamydomonas through the lens of genomics.
PubMed Identifier: 17291820
author list: Grossman AR, Croft M, Gladyshev VN, Merchant SS, Posewitz MC, Prochnik S, Spalding MH
published in: Current opinion in plant biology
information resource reference: Novel metabolism in Chlamydomonas through the lens of genomics. Curr Opin Plant Biol. 2007 Apr; 10(2):190-8.
journal title abbreviation: Curr Opin Plant Biol
publication date: 2007-02-08T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Network-driven discovery of repurposable drugs targeting hallmarks of aging.
PubMed Identifier: 40949755
author list: Gross B, Ehlert J, Gladyshev VN, Loscalzo J, Barabási AL
published in: ArXiv
information resource reference: Network-driven discovery of repurposable drugs targeting hallmarks of aging. ArXiv. 2025 Sep 03.
journal title abbreviation: ArXiv
publication date: 2025-09-03T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision.
PubMed Identifier: 40950238
author list: Lu YR, Cameron JC, Hu Y, Shen H, Shirahama S, Tyshkovskiy A, Chen Z, Ai J, Zhu DY, Karg MM, Chew LA, Bell GW, Jena SG, He Y, Seifert P, Shu DY, Ei-Brolosy MA, Lou Q, Zhang B, Puszynska AM, Qiu X, Tian X, Gregory-Ksander M, Gladyshev VN, Sinclair DA, Saint-Geniez M, Buenrostro JD, Rickman CB, Ksander BR, Weissman JS
published in: bioRxiv : the preprint server for biology
information resource reference: Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision. bioRxiv. 2025 Sep 01.
journal title abbreviation: bioRxiv
publication date: 2025-09-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation.
PubMed Identifier: 40667171
author list: Mitchell W, de Magalhães CG, Tyshkovskiy A, Uchida Y, Goeminne LJE, Ichimura T, Ng EL, Bonventre JV, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: In vivo chemical reprogramming is associated with a toxic accumulation of lipid droplets hindering rejuvenation. bioRxiv. 2025 Jun 27.
journal title abbreviation: bioRxiv
publication date: 2025-06-27T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.
PubMed Identifier: 40947308
author list: Murach KA, Dungan CM, Chambers TL, Horvath S, Nandakumar J, Gladyshev VN, Pletcher SD, Dai X, Guo L
published in: Aging cell
information resource reference: Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. Aging Cell. 2025 Nov; 24(11):e70236.
journal title abbreviation: Aging Cell
publication date: 2025-09-14T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale.
PubMed Identifier: 41315740
author list: Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov AY, Sun S, Wu Z, Gigas J, Hillpot EC, Martinez JC, Lee M, Williams A, Gilman A, Hamilton N, Strelkova E, Haseljic E, Patel A, Straight ME, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopmann MR, Moritz RL, Fujii S, Pelletier A, Hayman DJ, Liu H, Cai Y, Leung AKL, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Maley CC, Modesti M, Genovese G, Simons MJP, Vijg J, Seluanov A, Gorbunova V
published in: Nature
information resource reference: Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale. Nature. 2025 Dec; 648(8094):E14.
journal title abbreviation: Nature
publication date: 2025-12-01T00:00:00
year: 2025
type: Academic Article
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type: Document
type: Information Resource

IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures.
PubMed Identifier: 41279005
author list: Dowrey TW, Cranston SF, Skvir NJ, Lok Y, Bock P, Kharitonova EK, MacDonald E, Zeldich E, Gabel CV, Tyshkovskiy A, Monti S, Gladyshev VN, Sebastiani P, Perls TT, Andersen S, Murphy GJ
published in: bioRxiv : the preprint server for biology
information resource reference: IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures. bioRxiv. 2025 Oct 11.
journal title abbreviation: bioRxiv
publication date: 2025-10-11T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

OMICmAge quantifies biological age by integrating multi-omics with electronic medical records.
PubMed Identifier: 41741793
author list: Chen Q, Dwaraka VB, Carreras-Gallo N, Armstrong JF, Sehgal R, Argentieri MA, Richmond A, Aparicio A, Mendez K, Chen Y, Begum S, Kachroo P, Prince N, Guo T, Went H, Mendez T, Lin A, Turner L, Moqri M, Chu SH, Kelly RS, Weiss ST, Rattray NJW, Gladyshev VN, Karlson E, Wheelock CE, Mathé EA, Dahlin A, McGeachie MJ, Marioni RE, Higgins-Chen AT, Smith R, Lasky-Su J
published in: Nature aging
information resource reference: OMICmAge quantifies biological age by integrating multi-omics with electronic medical records. Nat Aging. 2026 Mar; 6(3):722-737.
journal title abbreviation: Nat Aging
publication date: 2026-02-25T00:00:00
year: 2026
type: Academic Article
type: Article
type: Document
type: Information Resource

Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations.
PubMed Identifier: 41676543
author list: Zhang Z, Simon M, Liang Y, Tyshkovskiy A, Kaplan M, Paige V, Biashad SA, Gladyshev V, Seluanov A, Gorbunova V
published in: bioRxiv : the preprint server for biology
information resource reference: Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 phosphorylation site mutations. bioRxiv. 2026 Feb 06.
journal title abbreviation: bioRxiv
publication date: 2026-02-06T00:00:00
year: 2026
type: Academic Article
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Skin health and biological aging.
PubMed Identifier: 40527938
author list: Furman D, Auwerx J, Bulteau AL, Church G, Couturaud V, Crabbe L, Davies KJA, Decottignies A, Gladyshev VN, Kennedy BK, Neretti N, Nizard C, Pays K, Robinton D, Sebastiano V, Watson REB, Wang MC, Woltjen K
published in: Nature aging
information resource reference: Skin health and biological aging. Nat Aging. 2025 Jul; 5(7):1195-1206.
journal title abbreviation: Nat Aging
publication date: 2025-06-17T00:00:00
year: 2025
type: Academic Article
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The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life.
PubMed Identifier: 40721431
author list: Rothi MH, Sarkar GC, Haddad JA, Mitchell W, Ying K, Pohl N, Sotomayor-Mena RG, Natale J, Dellacona S, Gladyshev VN, Greer EL
published in: Nature communications
information resource reference: The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life. Nat Commun. 2025 Jul 28; 16(1):6944.
journal title abbreviation: Nat Commun
publication date: 2025-07-28T00:00:00
year: 2025
type: Academic Article
type: Article
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type: Information Resource

MSRB3 antioxidant activity is necessary for inner ear cuticular plate structure and hair bundle integrity.
PubMed Identifier: 40827380
author list: Nayak G, Richard EM, Lee BC, Riordan GP, Belyantseva IA, Manta B, Friedman TB, Gladyshev VN, Riazuddin S
published in: Disease models & mechanisms
information resource reference: MSRB3 antioxidant activity is necessary for inner ear cuticular plate structure and hair bundle integrity. Dis Model Mech. 2025 Aug 01; 18(8).
journal title abbreviation: Dis Model Mech
publication date: 2025-08-01T00:00:00
year: 2025
type: Academic Article
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type: Information Resource

A National Institute on Aging workshop on the long-term effects of pregnancy on aging.
PubMed Identifier: 41299089
author list: Kim KI, Bello NA, Galea LAM, Gladyshev VN, Jasienska G, McKinley KL, Miller EC, Parks WT, Pollack AZ, Prewit EB, Rich-Edwards J, Ryan CP, Slaughter-Acey J, Stanhewicz AE, Warrington JP, Suh Y
published in: Nature aging
information resource reference: A National Institute on Aging workshop on the long-term effects of pregnancy on aging. Nat Aging. 2025 Dec; 5(12):2372-2375.
journal title abbreviation: Nat Aging
publication date: 2025-12-01T00:00:00
year: 2025
type: Academic Article
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type: Document
type: Information Resource

Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.
PubMed Identifier: 41217825
author list: Hernández-Arciga U, Kim JK, Fisher JL, Tyshkovskiy A, Moldakozhayev A, Hall C, Ghosh S, Govindaraj Y, Sipula IJ, Kastroll J, Cooke D, Luo J, Alder JK, Rizzo SJS, Ables GP, Choi E, Gladyshev VN, Jurczak MJ, Tatar M, Parkhitko AA
published in: JCI insight
information resource reference: Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health. JCI Insight. 2025 Dec 22; 10(24).
journal title abbreviation: JCI Insight
publication date: 2025-11-11T00:00:00
year: 2025
type: Academic Article
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Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model.
PubMed Identifier: 41509418
author list: Moldakozhayev A, Tyshkovskiy A, Nigro P, de Magalhães CG, Ying K, Eames AW, Poganik JR, Tskhay A, Zhang B, Tikhonov S, Anekal PV, Carbone NP, Hirshman MF, Goodyear LJ, Van Raamsdonk JM, Gladyshev VN
published in: bioRxiv : the preprint server for biology
information resource reference: Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model. bioRxiv. 2025 Dec 29.
journal title abbreviation: bioRxiv
publication date: 2025-12-29T00:00:00
year: 2025
type: Academic Article
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In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation.
PubMed Identifier: 41589348
author list: Mitchell W, de Magalhães CG, Tyshkovskiy A, Uchida Y, Goeminne LJE, Ichimura T, Ng EL, Moldakozhayev A, Bonventre JV, Gladyshev VN
published in: Aging cell
information resource reference: In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation. Aging Cell. 2026 Feb; 25(2):e70390.
journal title abbreviation: Aging Cell
publication date: 2026-02-01T00:00:00
year: 2026
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Samuel A. Levine Professor of Medicine; Hersey Distinguished Professor of the Theory and Practice of Physic
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HR job title: Samuel A. Levine Professor of Medicine; Hersey Distinguished Professor of the Theory and Practice of Physic
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Authorship 357105
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: [Draft macronuclear genome of a ciliate Euplotes crassus].

Authorship 743313
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast.

The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast.
PubMed Identifier: 24776987
author list: Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN
published in: G3 (Bethesda, Md.)
information resource reference: The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Apr 28; 4(7):1183-91.
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Authorship 325203
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linked author: Gladyshev, Vadim
linked information resource: Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila.

Authorship 326544
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linked author: Gladyshev, Vadim
linked information resource: Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.

Dean of the Faculty
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Authorship 30796
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linked author: Gladyshev, Vadim
linked information resource: Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice.

Authorship 469514
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis.

Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.
PubMed Identifier: 24719327
author list: Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE
published in: The Journal of biological chemistry
information resource reference: Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62.
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Authorship 749242
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linked information resource: Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.

Authorship 746149
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linked author: Gladyshev, Vadim
linked information resource: Selenoprotein S is involved in maintenance and transport of multiprotein complexes.

Authorship 753360
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linked author: Gladyshev, Vadim
linked information resource: Selenoproteins: molecular pathways and physiological roles.

Selenoproteins: molecular pathways and physiological roles.
PubMed Identifier: 24987004
author list: Labunskyy VM, Hatfield DL, Gladyshev VN
published in: Physiological reviews
information resource reference: Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77.
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publication date: 2014-07-01T00:00:00
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Authorship 419391
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linked author: Gladyshev, Vadim
linked information resource: Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.

Authorship 346772
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.

Authorship 525074
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues.

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.
PubMed Identifier: 25004091
author list: Guo C, Chen X, Song H, Maynard MA, Zhou Y, Lobanov AV, Gladyshev VN, Ganis JJ, Wiley D, Jugo RH, Lee NY, Castroneves LA, Zon LI, Scanlan TS, Feldman HA, Huang SA
published in: Endocrinology
information resource reference: Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80.
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Authorship 758540
type: Authorship
author rank in publication: 24
linked author: Gladyshev, Vadim
linked information resource: Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
PubMed Identifier: 25176646
author list: Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN
published in: Cell reports
information resource reference: Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014 Sep 11; 8(5):1354-64.
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Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.
PubMed Identifier: 25173844
author list: Kaya A, Lobanov AV, Gerashchenko MV, Koren A, Fomenko DE, Koc A, Gladyshev VN
published in: Genetics
information resource reference: Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae. Genetics. 2014 Nov; 198(3):905-17.
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Authorship 212250
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linked author: Gladyshev, Vadim
linked information resource: Analysis of selenocysteine-containing proteins.

Authorship 359699
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linked author: Gladyshev, Vadim
linked information resource: Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen.

Authorship 759312
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linked information resource: Translation inhibitors cause abnormalities in ribosome profiling experiments.

Authorship 759269
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author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.

Translation inhibitors cause abnormalities in ribosome profiling experiments.
PubMed Identifier: 25056308
author list: Gerashchenko MV, Gladyshev VN
published in: Nucleic acids research
information resource reference: Translation inhibitors cause abnormalities in ribosome profiling experiments. Nucleic Acids Res. 2014; 42(17):e134.
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Authorship 370720
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linked information resource: Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione.

Authorship 39148
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author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Functions and evolution of selenoprotein methionine sulfoxide reductases.

Authorship 769589
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linked information resource: Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.

Authorship 770600
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linked author: Gladyshev, Vadim
linked information resource: The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.

The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.
PubMed Identifier: 25411232
author list: Seim I, Ma S, Zhou X, Gerashchenko MV, Lee SG, Suydam R, George JC, Bickham JW, Gladyshev VN
published in: Aging
information resource reference: The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal. Aging (Albany NY). 2014 Oct; 6(10):879-99.
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Authorship 366202
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linked information resource: SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.

Authorship 374673
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author rank in publication: 2
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linked information resource: The prokaryotic selenoproteome.

Authorship 508405
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linked author: Gladyshev, Vadim
linked information resource: A new human selenium-containing protein. Purification, characterization, and cDNA sequence.

Authorship 534152
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linked author: Gladyshev, Vadim
linked information resource: Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.

Authorship 537541
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linked information resource: The naked mole rat genome: understanding aging through genome analysis.

Authorship 539777
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linked information resource: NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.

Authorship 560387
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linked information resource: Is there a twenty third amino acid in the genetic code?

Authorship 40284
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linked author: Gladyshev, Vadim
linked information resource: Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.

Authorship 86487
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linked information resource: The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A.

Authorship 386179
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linked information resource: Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice.

Authorship 400
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linked information resource: General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se.

Authorship 404928
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linked information resource: Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.

Authorship 383664
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linked information resource: Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis.

Authorship 444771
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linked information resource: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.

Authorship 421263
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linked information resource: Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli.

Authorship 332006
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linked information resource: Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.

Authorship 471422
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linked information resource: Characterization of protein targets of mammalian thioredoxin reductases.

Authorship 432597
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linked information resource: Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines.

Authorship 229604
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linked information resource: The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development.

Authorship 451811
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linked information resource: Genetic and functional analysis of mammalian Sep15 selenoprotein.

Authorship 303239
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Authorship 359163
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linked information resource: A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines.

Authorship 499396
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Authorship 462845
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Authorship 470742
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linked information resource: A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues.

Authorship 479039
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linked information resource: Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.

Authorship 484520
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Authorship 491053
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Authorship 389020
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linked information resource: X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis.

Authorship 571324
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Authorship 406715
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Gene expression defines natural changes in mammalian lifespan.
PubMed Identifier: 25677554
author list: Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Buffenstein R, Lee SR, Chang KT, Rhee H, Kim JS, Yang KS, Gladyshev VN
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information resource reference: Gene expression defines natural changes in mammalian lifespan. Aging Cell. 2015 Jun; 14(3):352-65.
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Authorship 172893
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Authorship 449001
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Authorship 47083
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Authorship 489377
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Authorship 521314
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Authorship 562986
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Authorship 58383
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Authorship 86214
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Authorship 94327
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Authorship 305637
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Authorship 347233
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Authorship 386810
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Authorship 269692
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Authorship 227679
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Authorship 72292
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Authorship 81747
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Authorship 337171
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Authorship 410992
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Authorship 135816
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Authorship 396800
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Authorship 242776
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Authorship 271166
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Authorship 343207
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Authorship 357613
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Authorship 376685
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Authorship 389915
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linked information resource: Characterization of mammalian selenoproteomes.

Authorship 526888
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linked information resource: Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.

Authorship 231809
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Authorship 345115
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Authorship 370247
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linked information resource: CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.

Authorship 449128
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linked information resource: Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2.

Authorship 548824
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linked information resource: Role of selenium-containing proteins in T-cell and macrophage function.

Authorship 550188
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linked information resource: Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

Authorship 794825
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linked information resource: Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors.

Authorship 795961
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linked information resource: Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

Authorship 791938
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linked information resource: Genome-wide association study of selenium concentrations.

Authorship 805549
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linked information resource: Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.

Authorship 792940
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linked information resource: Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine.

Authorship 791966
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linked information resource: The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.

Authorship 798621
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linked information resource: Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.

Authorship 790975
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linked information resource: Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.

Authorship 789450
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linked information resource: Endogenous hydrogen sulfide production is essential for dietary restriction benefits.

Authorship 796222
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linked information resource: Comparative genetics of longevity and cancer: insights from long-lived rodents.

Authorship 788286
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linked author: Gladyshev, Vadim
linked information resource: Gene expression defines natural changes in mammalian lifespan.

Authorship 804729
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linked information resource: INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Authorship 806799
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linked information resource: Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.

Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.
PubMed Identifier: 25529450
author list: Bang J, Jang M, Huh JH, Na JW, Shim M, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ
published in: Biochemical and biophysical research communications
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The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.
PubMed Identifier: 25886253
author list: Tsuji PA, Carlson BA, Yoo MH, Naranjo-Suarez S, Xu XM, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL
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Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.
PubMed Identifier: 25561728
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Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.
PubMed Identifier: 25702753
author list: Kaya A, Lobanov AV, Gladyshev VN
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Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.
PubMed Identifier: 25645816
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published in: Aging cell
information resource reference: Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 2015 Apr; 14(2):288-91.
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Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors.
PubMed Identifier: 25799144
author list: Tarrago L, Péterfi Z, Lee BC, Michel T, Gladyshev VN
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Genome-wide association study of selenium concentrations.
PubMed Identifier: 25343990
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Comparative genetics of longevity and cancer: insights from long-lived rodents.
PubMed Identifier: 24981598
author list: Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J
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Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine.
PubMed Identifier: 25912135
author list: Kim MJ, Lee BC, Hwang KY, Gladyshev VN, Kim HY
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Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
PubMed Identifier: 25542313
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INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.
PubMed Identifier: 25550505
author list: Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A
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information resource reference: INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1053-8.
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type: Article
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Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.
PubMed Identifier: 25728752
author list: Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ
published in: Molecules and cells
information resource reference: Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells. Mol Cells. 2015 May; 38(5):457-65.
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Authorship 245937
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Authorship 274162
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linked information resource: Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance.

Authorship 3481
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linked author: Gladyshev, Vadim
linked information resource: Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress.

Authorship 304417
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Authorship 378376
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linked author: Gladyshev, Vadim
linked information resource: High-throughput identification of catalytic redox-active cysteine residues.

Authorship 397675
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linked information resource: Identification of molybdopterins in molybdenum- and selenium-containing enzymes.

Authorship 378653
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linked author: Gladyshev, Vadim
linked information resource: Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues.

Authorship 381291
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Authorship 417770
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linked information resource: Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life.

Authorship 440126
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author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.

Authorship 44138
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.

Authorship 460446
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linked author: Gladyshev, Vadim
linked information resource: Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.

Authorship 282171
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linked information resource: Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.

Authorship 818631
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linked information resource: Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.
PubMed Identifier: 26165157
author list: Gould NS, Evans P, Martínez-Acedo P, Marino SM, Gladyshev VN, Carroll KS, Ischiropoulos H
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information resource reference: Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. Chem Biol. 2015 Jul 23; 22(7):965-75.
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Authorship 822951
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linked information resource: Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.
PubMed Identifier: 26244935
author list: Ma S, Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R, Lewis KN, Park TJ, Miller RA, Clish CB, Gladyshev VN
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Authorship 501207
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linked information resource: Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase.

Authorship 501596
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author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Genomics perspective on disulfide bond formation.

Authorship 831629
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linked author: Gladyshev, Vadim
linked information resource: Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.

Authorship 831203
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author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.
PubMed Identifier: 26194102
author list: Mariotti M, Santesmasses D, Capella-Gutierrez S, Mateo A, Arnan C, Johnson R, D'Aniello S, Yim SH, Gladyshev VN, Serras F, Corominas M, Gabaldón T, Guigó R
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Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.
PubMed Identifier: 26261310
author list: Kaya A, Gerashchenko MV, Seim I, Labarre J, Toledano MB, Gladyshev VN
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Authorship 544380
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linked author: Gladyshev, Vadim
linked information resource: Pyrrolysine and selenocysteine use dissimilar decoding strategies.

Authorship 559997
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linked author: Gladyshev, Vadim
linked information resource: Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.

Authorship 569130
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Composition and evolution of the vertebrate and mammalian selenoproteomes.

Authorship 837558
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.
PubMed Identifier: 26181576
author list: Kaya A, Lee BC, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1. Antioxid Redox Signal. 2015 Oct 01; 23(10):814-22.
journal title abbreviation: Antioxid Redox Signal
publication date: 2015-07-16T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 387231
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Identification of trace element-containing proteins in genomic databases.

Authorship 840188
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Selenium and Methionine Sulfoxide Reduction.

Authorship 840003
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.

Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.
PubMed Identifier: 26452064
author list: Turanov AA, Everley RA, Hybsier S, Renko K, Schomburg L, Gygi SP, Hatfield DL, Gladyshev VN
published in: PloS one
information resource reference: Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine. PLoS One. 2015; 10(10):e0140353.
journal title abbreviation: PLoS One
publication date: 2015-10-09T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenium and Methionine Sulfoxide Reduction.
PubMed Identifier: 26461418
author list: Gladyshev VN
published in: Free radical biology & medicine
information resource reference: Selenium and Methionine Sulfoxide Reduction. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S8-9.
journal title abbreviation: Free Radic Biol Med
publication date: 2014-12-10T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 477324
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.

Authorship 48659
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.

Authorship 497958
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.

Authorship 847440
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Authorship 849727
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Convergent evolution of marine mammals is associated with distinct substitutions in common genes.

Authorship 848301
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.

Convergent evolution of marine mammals is associated with distinct substitutions in common genes.
PubMed Identifier: 26549748
author list: Zhou X, Seim I, Gladyshev VN
published in: Scientific reports
information resource reference: Convergent evolution of marine mammals is associated with distinct substitutions in common genes. Sci Rep. 2015 Nov 09; 5:16550.
journal title abbreviation: Sci Rep
publication date: 2015-11-09T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.
PubMed Identifier: 26549444
author list: Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN
published in: Cell reports
information resource reference: Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep. 2015 Nov 17; 13(7):1319-1326.
journal title abbreviation: Cell Rep
publication date: 2015-11-05T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
PubMed Identifier: 26569310
author list: Tobe R, Carlson BA, Tsuji PA, Lee BJ, Gladyshev VN, Hatfield DL
published in: Cancers
information resource reference: Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers (Basel). 2015 Nov 10; 7(4):2262-76.
journal title abbreviation: Cancers (Basel)
publication date: 2015-11-10T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 452689
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution.

Authorship 467684
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.

Authorship 515897
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases.

Authorship 858489
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: DNA repair in species with extreme lifespan differences.

DNA repair in species with extreme lifespan differences.
PubMed Identifier: 26729707
author list: MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J
published in: Aging
information resource reference: DNA repair in species with extreme lifespan differences. Aging (Albany NY). 2015 Dec; 7(12):1171-84.
journal title abbreviation: Aging (Albany NY)
publication date: 2015-12-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 67480
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reduction and the aging process.

Authorship 29779
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses.

Authorship 300780
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme.

Authorship 320026
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.

Authorship 872955
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Methionine restriction and life-span control.

Methionine restriction and life-span control.
PubMed Identifier: 26663138
author list: Lee BC, Kaya A, Gladyshev VN
published in: Annals of the New York Academy of Sciences
information resource reference: Methionine restriction and life-span control. Ann N Y Acad Sci. 2016 Jan; 1363:116-24.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2015-12-10T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 372204
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells.

Authorship 453683
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase.

Authorship 886043
type: Authorship
author rank in publication: 22
linked author: Gladyshev, Vadim
linked information resource: Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Authorship 563422
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.
PubMed Identifier: 27163160
author list: Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coskun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V
published in: Aging
information resource reference: Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY). 2016 05; 8(5):841-7.
journal title abbreviation: Aging (Albany NY)
publication date: 2016-05-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 553035
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 66911
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila.

Authorship 97130
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family.

Authorship 890801
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

Authorship 891827
type: Authorship
author rank in publication: 17
linked author: Gladyshev, Vadim
linked information resource: Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.
PubMed Identifier: 27060562
author list: Gladyshev VN
published in: Aging cell
information resource reference: Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell. 2016 08; 15(4):594-602.
journal title abbreviation: Aging Cell
publication date: 2016-04-06T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.
PubMed Identifier: 27208177
author list: Tobe R, Carlson BA, Huh JH, Castro NP, Xu XM, Tsuji PA, Lee SG, Bang J, Na JW, Kong YY, Beaglehole D, Southon E, Seifried H, Tessarollo L, Salomon DS, Schweizer U, Gladyshev VN, Hatfield DL, Lee BJ
published in: The Biochemical journal
information resource reference: Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 07 15; 473(14):2141-54.
journal title abbreviation: Biochem J
publication date: 2016-05-16T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 4897
type: Authorship
author rank in publication: 36
linked author: Gladyshev, Vadim
linked information resource: Genome sequencing reveals insights into physiology and longevity of the naked mole rat.

Authorship 509688
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression.

Authorship 521428
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.

Authorship 549687
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme.

Authorship 550671
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.

Authorship 553806
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.

Authorship 57585
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Structure and catalytic mechanism of eukaryotic selenocysteine synthase.

Authorship 897224
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.
PubMed Identifier: 27515585
author list: Podolskiy DI, Lobanov AV, Kryukov GV, Gladyshev VN
published in: Nature communications
information resource reference: Analysis of cancer genomes reveals basic features of human aging and its role in cancer development. Nat Commun. 2016 08 12; 7:12157.
journal title abbreviation: Nat Commun
publication date: 2016-08-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 900871
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.

Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.
PubMed Identifier: 27413050
author list: Mariotti M, Lobanov AV, Manta B, Santesmasses D, Bofill A, Guigó R, Gabaldón T, Gladyshev VN
published in: Molecular biology and evolution
information resource reference: Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Mol Biol Evol. 2016 09; 33(9):2441-53.
journal title abbreviation: Mol Biol Evol
publication date: 2016-07-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 508754
type: Authorship
author rank in publication: 32
linked author: Gladyshev, Vadim
linked information resource: Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics.

Authorship 511947
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals.

Authorship 518426
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.

Mechanisms of lifespan control
end date: 2019-12-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2013-09-30
type: Grant
sponsor award id: DP1AG047745

Functions of thioredoxin reductases and their targets
end date: 2020-11-30
principal investigator name: GLADYSHEV, VADIM N.
start date: 2002-05-01
type: Grant
sponsor award id: R37GM065204

Selenoproteins as targets for cancer prevention
end date: 2021-03-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2001-04-01
type: Grant
sponsor award id: R01CA080946

Redox mechanism of cancer prevention by selenium
end date: 2004-08-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2001-09-30
type: Grant
sponsor award id: R03ES011403

Identity and Function of Selenoprotein Genes
end date: 2017-06-30
principal investigator name: GLADYSHEV, VADIM N.
start date: 2000-07-01
type: Grant
sponsor award id: R01GM061603

Understanding the Causes of Aging
end date: 2014-10-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2010-08-01
type: Grant
sponsor award id: R01AG038004

Nebraska Center for Cellular Signaling
end date: 2013-06-30
principal investigator name: JOHNSON, KEITH R
start date: 2003-09-19
type: Grant
sponsor award id: P20RR018759

Methionine sulfoxide reduction, selenium and aging
end date: 2021-04-30
principal investigator name: GLADYSHEV, VADIM N.
start date: 2003-01-15
type: Grant
sponsor award id: R01AG021518

Redox Biology Center
end date: 2012-08-31
principal investigator name: BECKER, DONALD F
start date: 2002-09-30
type: Grant
sponsor award id: P20RR017675

Comparative genomes of longevity
end date: 2019-04-30
principal investigator name: GORBUNOVA, VERA
start date: 2014-05-01
type: Grant
sponsor award id: P01AG047200

Arterial Dysfunction: Basic and Clinical Mechanisms
end date: 2017-03-31
principal investigator name: MICHEL, THOMAS
start date: 1992-09-30
type: Grant
sponsor award id: P01HL048743

Functions of Mammalian Thioredoxin Reductases
end date: 2011-01-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2002-05-01
type: Grant
sponsor award id: R01GM065204

Function of thioredoxin glutathione reductase
end date: 2008-07-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2004-08-01
type: Grant
sponsor award id: R03TW006959

2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference
end date: 2007-05-31
principal investigator name: GLADYSHEV, VADIM N.
start date: 2006-06-07
type: Grant
sponsor award id: R13CA121806

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: 2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Functions of thioredoxin reductases and their targets

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Selenoproteins as targets for cancer prevention

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Mechanisms of lifespan control

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Methionine sulfoxide reduction, selenium and aging

Co-Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Redox Biology Center

Co-Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Nebraska Center for Cellular Signaling

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Functions of Mammalian Thioredoxin Reductases

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Redox mechanism of cancer prevention by selenium

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Understanding the Causes of Aging

Co-Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Comparative genomes of longevity

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Identity and Function of Selenoprotein Genes

Co-Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Arterial Dysfunction: Basic and Clinical Mechanisms

Principal Investigator
type: Researcher Role
researcher role of: Gladyshev, Vadim
contributes to: Function of thioredoxin glutathione reductase

Authorship 916992
type: Authorship
author rank in publication: 29
linked author: Gladyshev, Vadim
linked information resource: Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys.

Authorship 916585
type: Authorship
author rank in publication: 18
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
PubMed Identifier: 27588899
author list: Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2016-09-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys.
PubMed Identifier: 27555581
author list: Zhou X, Meng X, Liu Z, Chang J, Wang B, Li M, Wengel PO, Tian S, Wen C, Wang Z, Garber PA, Pan H, Ye X, Xiang Z, Bruford MW, Edwards SV, Cao Y, Yu S, Gao L, Cao Z, Liu G, Ren B, Shi F, Peterfi Z, Li D, Li B, Jiang Z, Li J, Gladyshev VN, Li R, Li M
published in: Molecular biology and evolution
information resource reference: Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Mol Biol Evol. 2016 10; 33(10):2670-81.
journal title abbreviation: Mol Biol Evol
publication date: 2016-08-23T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 82410
type: Authorship
author rank in publication: 12
linked author: Gladyshev, Vadim
linked information resource: High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.

Authorship 329581
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.

Authorship 921101
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.

Authorship 923479
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein Gene Nomenclature.

Authorship 920918
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum.

Authorship 921997
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Authorship 928637
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Intrinsic Versus Extrinsic Cancer Risk Factors and Aging.

Authorship 926381
type: Authorship
author rank in publication: 5
linked author: Gladyshev, Vadim
linked information resource: Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths.

Authorship 921659
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Comparative Genomics and Evolution of Molybdenum Utilization.

Authorship 924900
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.

Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.
PubMed Identifier: 27345570
author list: Péterfi Z, Tarrago L, Gladyshev VN
published in: Methods (San Diego, Calif.)
information resource reference: Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide. Methods. 2016 10 15; 109:149-157.
journal title abbreviation: Methods
publication date: 2016-06-23T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths.
PubMed Identifier: 20385027
author list: Otero L, Bonilla M, Protasio AV, Fernández C, Gladyshev VN, Salinas G
published in: BMC genomics
information resource reference: Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths. BMC Genomics. 2010 Apr 13; 11:237.
journal title abbreviation: BMC Genomics
publication date: 2010-04-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.
PubMed Identifier: 27030810
author list: Kaya A, Ma S, Wasko B, Lee M, Kaeberlein M, Gladyshev VN
published in: NPJ aging and mechanisms of disease
information resource reference: Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates. NPJ Aging Mech Dis. 2015; 1.
journal title abbreviation: NPJ Aging Mech Dis
publication date: 2015-09-28T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative Genomics and Evolution of Molybdenum Utilization.
PubMed Identifier: 22451726
author list: Zhang Y, Rump S, Gladyshev VN
published in: Coordination chemistry reviews
information resource reference: Comparative Genomics and Evolution of Molybdenum Utilization. Coord Chem Rev. 2011 May; 255(9-10):1206-1217.
journal title abbreviation: Coord Chem Rev
publication date: 2011-05-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Intrinsic Versus Extrinsic Cancer Risk Factors and Aging.
PubMed Identifier: 27544777
author list: Podolskiy DI, Gladyshev VN
published in: Trends in molecular medicine
information resource reference: Intrinsic Versus Extrinsic Cancer Risk Factors and Aging. Trends Mol Med. 2016 Oct; 22(10):833-834.
journal title abbreviation: Trends Mol Med
publication date: 2016-08-17T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.
PubMed Identifier: 27262435
author list: Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL, Conrad M
published in: Redox biology
information resource reference: Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biol. 2016 10; 9:22-31.
journal title abbreviation: Redox Biol
publication date: 2016-05-26T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum.
PubMed Identifier: 27501944
author list: Heaphy SM, Mariotti M, Gladyshev VN, Atkins JF, Baranov PV
published in: Molecular biology and evolution
information resource reference: Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Mol Biol Evol. 2016 11; 33(11):2885-2889.
journal title abbreviation: Mol Biol Evol
publication date: 2016-08-08T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein Gene Nomenclature.
PubMed Identifier: 27645994
author list: Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
published in: The Journal of biological chemistry
information resource reference: Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040.
journal title abbreviation: J Biol Chem
publication date: 2016-09-19T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.
PubMed Identifier: 26381228
author list: Bisio H, Bonilla M, Manta B, Graña M, Salzman V, Aguilar PS, Gladyshev VN, Comini MA, Salinas G
published in: Antioxidants & redox signaling
information resource reference: A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters. Antioxid Redox Signal. 2016 01 27; 24(4):205-216.
journal title abbreviation: Antioxid Redox Signal
publication date: 2015-10-27T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 934656
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Authorship 936145
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.

Authorship 934986
type: Authorship
author rank in publication: 15
linked author: Gladyshev, Vadim
linked information resource: Position-dependent termination and widespread obligatory frameshifting in Euplotes translation.

Position-dependent termination and widespread obligatory frameshifting in Euplotes translation.
PubMed Identifier: 27870834
author list: Lobanov AV, Heaphy SM, Turanov AA, Gerashchenko MV, Pucciarelli S, Devaraj RR, Xie F, Petyuk VA, Smith RD, Klobutcher LA, Atkins JF, Miceli C, Hatfield DL, Baranov PV, Gladyshev VN
published in: Nature structural & molecular biology
information resource reference: Position-dependent termination and widespread obligatory frameshifting in Euplotes translation. Nat Struct Mol Biol. 2017 01; 24(1):61-68.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2016-11-21T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice.
PubMed Identifier: 27838938
author list: Heo JY, Cha HN, Kim KY, Lee E, Kim SJ, Kim YW, Kim JY, Lee IK, Gladyshev VN, Kim HY, Park SY
published in: Free radical research
information resource reference: Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice. Free Radic Res. 2017 Jan; 51(1):24-37.
journal title abbreviation: Free Radic Res
publication date: 2016-12-09T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.
PubMed Identifier: 27874830
author list: Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN
published in: eLife
information resource reference: Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife. 2016 11 22; 5.
journal title abbreviation: Elife
publication date: 2016-11-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 5808
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Molybdoproteomes and evolution of molybdenum utilization.

Authorship 67870
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Analysis and functional prediction of reactive cysteine residues.

Authorship 69893
type: Authorship
author rank in publication: 13
linked author: Gladyshev, Vadim
linked information resource: The second international conference "genetics of aging and longevity".

Authorship 9432
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.

Authorship 256088
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases.

Authorship 269687
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.

Authorship 30591
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Dual functions of codons in the genetic code.

Authorship 320621
type: Authorship
author rank in publication: 1
linked author: Gladyshev, Vadim
linked information resource: Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri.

Authorship 407769
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.

Authorship 408041
type: Authorship
author rank in publication: 9
linked author: Gladyshev, Vadim
linked information resource: Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery.

Authorship 491318
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.

Authorship 952493
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.
PubMed Identifier: 28108278
author list: Payne NC, Geissler A, Button A, Sasuclark AR, Schroll AL, Ruggles EL, Gladyshev VN, Hondal RJ
published in: Free radical biology & medicine
information resource reference: Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil. Free Radic Biol Med. 2017 03; 104:249-261.
journal title abbreviation: Free Radic Biol Med
publication date: 2017-01-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 954061
type: Authorship
author rank in publication: 20
linked author: Gladyshev, Vadim
linked information resource: A review of the biomedical innovations for healthy longevity.

A review of the biomedical innovations for healthy longevity.
PubMed Identifier: 28132958
author list: Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A
published in: Aging
information resource reference: A review of the biomedical innovations for healthy longevity. Aging (Albany NY). 2017 Jan 29; 9(1):7-25.
journal title abbreviation: Aging (Albany NY)
publication date: 2017-01-29T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 958096
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Ribonuclease selection for ribosome profiling.

Authorship 958213
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Regulated methionine oxidation by monooxygenases.

Ribonuclease selection for ribosome profiling.
PubMed Identifier: 27638886
author list: Gerashchenko MV, Gladyshev VN
published in: Nucleic acids research
information resource reference: Ribonuclease selection for ribosome profiling. Nucleic Acids Res. 2017 01 25; 45(2):e6.
journal title abbreviation: Nucleic Acids Res
publication date: 2016-09-15T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulated methionine oxidation by monooxygenases.
PubMed Identifier: 28229915
author list: Manta B, Gladyshev VN
published in: Free radical biology & medicine
information resource reference: Regulated methionine oxidation by monooxygenases. Free Radic Biol Med. 2017 08; 109:141-155.
journal title abbreviation: Free Radic Biol Med
publication date: 2017-02-14T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

A new human selenium-containing protein. Purification, characterization, and cDNA sequence.
PubMed Identifier: 9535873
author list: Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10; 273(15):8910-5.
journal title abbreviation: J Biol Chem
publication date: 1998-04-10T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine-containing proteins in mammals.
PubMed Identifier: 10343164
author list: Gladyshev VN, Hatfield DL
published in: Journal of biomedical science
information resource reference: Selenocysteine-containing proteins in mammals. J Biomed Sci. 1999 May-Jun; 6(3):151-60.
journal title abbreviation: J Biomed Sci
publication date: 1999-05-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii.
PubMed Identifier: 12110581
author list: Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN
published in: The EMBO journal
information resource reference: Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J. 2002 Jul 15; 21(14):3681-93.
journal title abbreviation: EMBO J
publication date: 2002-07-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolution of selenium utilization traits.
PubMed Identifier: 16086848
author list: Romero H, Zhang Y, Gladyshev VN, Salinas G
published in: Genome biology
information resource reference: Evolution of selenium utilization traits. Genome Biol. 2005; 6(8):R66.
journal title abbreviation: Genome Biol
publication date: 2005-07-27T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase.
PubMed Identifier: 16774913
author list: Turanov AA, Su D, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. J Biol Chem. 2006 Aug 11; 281(32):22953-63.
journal title abbreviation: J Biol Chem
publication date: 2006-06-14T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 959790
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.

Characterization of mammalian selenoproteomes.
PubMed Identifier: 12775843
author list: Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN
published in: Science (New York, N.Y.)
information resource reference: Characterization of mammalian selenoproteomes. Science. 2003 May 30; 300(5624):1439-43.
journal title abbreviation: Science
publication date: 2003-05-30T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 965067
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: A Disease or Not a Disease? Aging As a Pathology.

Authorship 965719
type: Authorship
author rank in publication: 38
linked author: Gladyshev, Vadim
linked information resource: Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies.

Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies.
PubMed Identifier: 27646534
author list: Li M, Chen L, Tian S, Lin Y, Tang Q, Zhou X, Li D, Yeung CKL, Che T, Jin L, Fu Y, Ma J, Wang X, Jiang A, Lan J, Pan Q, Liu Y, Luo Z, Guo Z, Liu H, Zhu L, Shuai S, Tang G, Zhao J, Jiang Y, Bai L, Zhang S, Mai M, Li C, Wang D, Gu Y, Wang G, Lu H, Li Y, Zhu H, Li Z, Li M, Gladyshev VN, Jiang Z, Zhao S, Wang J, Li R, Li X
published in: Genome research
information resource reference: Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies. Genome Res. 2017 05; 27(5):865-874.
journal title abbreviation: Genome Res
publication date: 2016-09-19T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

A Disease or Not a Disease? Aging As a Pathology.
PubMed Identifier: 27793599
author list: Gladyshev TV, Gladyshev VN
published in: Trends in molecular medicine
information resource reference: A Disease or Not a Disease? Aging As a Pathology. Trends Mol Med. 2016 12; 22(12):995-996.
journal title abbreviation: Trends Mol Med
publication date: 2016-10-25T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 968547
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Age-associated molecular changes are deleterious and may modulate life span through diet.

Age-associated molecular changes are deleterious and may modulate life span through diet.
PubMed Identifier: 28232953
author list: Lee SG, Kaya A, Avanesov AS, Podolskiy DI, Song EJ, Go DM, Jin GD, Hwang JY, Kim EB, Kim DY, Gladyshev VN
published in: Science advances
information resource reference: Age-associated molecular changes are deleterious and may modulate life span through diet. Sci Adv. 2017 Feb; 3(2):e1601833.
journal title abbreviation: Sci Adv
publication date: 2017-02-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines.
PubMed Identifier: 10874123
author list: Mansur DB, Hao H, Gladyshev VN, Korotkov KV, Hu Y, Moustafa ME, El-Saadani MA, Carlson BA, Hatfield DL, Diamond AM
published in: Biochemical pharmacology
information resource reference: Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem Pharmacol. 2000 Aug 15; 60(4):489-97.
journal title abbreviation: Biochem Pharmacol
publication date: 2000-08-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.
PubMed Identifier: 11259642
author list: Sun QA, Kirnarsky L, Sherman S, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3673-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-03-20T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds.
PubMed Identifier: 11807942
author list: Gladyshev VN
published in: Proteins
information resource reference: Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds. Proteins. 2002 Feb 01; 46(2):149-52.
journal title abbreviation: Proteins
publication date: 2002-02-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparison of selenium-containing molybdoenzymes.
PubMed Identifier: 11913139
author list: Gladyshev VN
published in: Metal ions in biological systems
information resource reference: Comparison of selenium-containing molybdoenzymes. Met Ions Biol Syst. 2002; 39:655-72.
journal title abbreviation: Met Ions Biol Syst
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development.
PubMed Identifier: 14612395
author list: Kwon SY, Badenhorst P, Martin-Romero FJ, Carlson BA, Paterson BM, Gladyshev VN, Lee BJ, Hatfield DL
published in: Molecular and cellular biology
information resource reference: The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Mol Cell Biol. 2003 Dec; 23(23):8495-504.
journal title abbreviation: Mol Cell Biol
publication date: 2003-12-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase.
PubMed Identifier: 16129668
author list: Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. J Biol Chem. 2005 Nov 11; 280(45):37839-45.
journal title abbreviation: J Biol Chem
publication date: 2005-08-29T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 975627
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.
PubMed Identifier: 28380383
author list: Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN
published in: Cell metabolism
information resource reference: Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions. Cell Metab. 2017 Apr 04; 25(4):954-960.e6.
journal title abbreviation: Cell Metab
publication date: 2017-04-04T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli.
PubMed Identifier: 15863725
author list: Su D, Li Y, Gladyshev VN
published in: Nucleic acids research
information resource reference: Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli. Nucleic Acids Res. 2005; 33(8):2486-92.
journal title abbreviation: Nucleic Acids Res
publication date: 2005-04-29T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
PubMed Identifier: 16319061
author list: Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J
published in: The Journal of biological chemistry
information resource reference: NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10; 281(6):3536-43.
journal title abbreviation: J Biol Chem
publication date: 2005-11-30T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.
PubMed Identifier: 17169995
author list: Mix H, Lobanov AV, Gladyshev VN
published in: Nucleic acids research
information resource reference: SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Res. 2007; 35(2):414-23.
journal title abbreviation: Nucleic Acids Res
publication date: 2006-12-14T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine-containing thioredoxin reductase in C. elegans.
PubMed Identifier: 10362494
author list: Gladyshev VN, Krause M, Xu XM, Korotkov KV, Kryukov GV, Sun QA, Lee BJ, Wootton JC, Hatfield DL
published in: Biochemical and biophysical research communications
information resource reference: Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem Biophys Res Commun. 1999 Jun 07; 259(2):244-9.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1999-06-07T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function.
PubMed Identifier: 12237451
author list: Fomenko DE, Gladyshev VN
published in: Protein science : a publication of the Protein Society
information resource reference: CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Protein Sci. 2002 Oct; 11(10):2285-96.
journal title abbreviation: Protein Sci
publication date: 2002-10-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.
PubMed Identifier: 15901730
author list: Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem. 2005 Jul 15; 280(28):26491-8.
journal title abbreviation: J Biol Chem
publication date: 2005-05-18T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 979189
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Non-enzymatic molecular damage as a prototypic driver of aging.

Non-enzymatic molecular damage as a prototypic driver of aging.
PubMed Identifier: 28264930
author list: Golubev A, Hanson AD, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Non-enzymatic molecular damage as a prototypic driver of aging. J Biol Chem. 2017 04 14; 292(15):6029-6038.
journal title abbreviation: J Biol Chem
publication date: 2017-03-06T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

How selenium has altered our understanding of the genetic code.
PubMed Identifier: 11997494
author list: Hatfield DL, Gladyshev VN
published in: Molecular and cellular biology
information resource reference: How selenium has altered our understanding of the genetic code. Mol Cell Biol. 2002 Jun; 22(11):3565-76.
journal title abbreviation: Mol Cell Biol
publication date: 2002-06-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2.
PubMed Identifier: 11397793
author list: Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, Kryukov VM, Kryukov GV, Lou MF
published in: The Journal of biological chemistry
information resource reference: Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem. 2001 Aug 10; 276(32):30374-80.
journal title abbreviation: J Biol Chem
publication date: 2001-06-07T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

77 Avenue Louis Pasteur
type: Address
address line 1: Harvard Institutes of Medicine
address line 2: BWH/Genetics - Rm 435
address line 3: 77 Avenue Louis Pasteur
city: Boston
postal code: 02115
state or province: MA

Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster.
PubMed Identifier: 9036855
author list: Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD
published in: Science (New York, N.Y.)
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Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.
PubMed Identifier: 11060283
author list: Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
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Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues.
PubMed Identifier: 17054778
author list: Zhang Y, Romero H, Salinas G, Gladyshev VN
published in: Genome biology
information resource reference: Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues. Genome Biol. 2006; 7(10):R94.
journal title abbreviation: Genome Biol
publication date: 2006-10-20T00:00:00
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Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods.
PubMed Identifier: 11898441
author list: Kryukov GV, Gladyshev VN
published in: Methods in enzymology
information resource reference: Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. Methods Enzymol. 2002; 347:84-100.
journal title abbreviation: Methods Enzymol
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The Plasmodium selenoproteome.
PubMed Identifier: 16428245
author list: Lobanov AV, Delgado C, Rahlfs S, Novoselov SV, Kryukov GV, Gromer S, Hatfield DL, Becker K, Gladyshev VN
published in: Nucleic acids research
information resource reference: The Plasmodium selenoproteome. Nucleic Acids Res. 2006; 34(2):496-505.
journal title abbreviation: Nucleic Acids Res
publication date: 2006-01-20T00:00:00
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Role of selenium-containing proteins in T-cell and macrophage function.
PubMed Identifier: 20576203
author list: Carlson BA, Yoo MH, Shrimali RK, Irons R, Gladyshev VN, Hatfield DL, Park JM
published in: The Proceedings of the Nutrition Society
information resource reference: Role of selenium-containing proteins in T-cell and macrophage function. Proc Nutr Soc. 2010 Aug; 69(3):300-10.
journal title abbreviation: Proc Nutr Soc
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Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae.
PubMed Identifier: 20698499
author list: Marino SM, Li Y, Fomenko DE, Agisheva N, Cerny RL, Gladyshev VN
published in: Biochemistry
information resource reference: Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae. Biochemistry. 2010 Sep 07; 49(35):7709-21.
journal title abbreviation: Biochemistry
publication date: 2010-09-07T00:00:00
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Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.
PubMed Identifier: 11839807
author list: Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN
published in: Molecular and cellular biology
information resource reference: Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol Cell Biol. 2002 Mar; 22(5):1402-11.
journal title abbreviation: Mol Cell Biol
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Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.
PubMed Identifier: 21194350
author list: Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36.
journal title abbreviation: Antioxid Redox Signal
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Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
PubMed Identifier: 16217027
author list: Biterova EI, Turanov AA, Gladyshev VN, Barycki JJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15018-23.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-10-10T00:00:00
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¹H, ¹³C, and ¹5N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR.
PubMed Identifier: 21901408
author list: Shumilina E, Soldà A, Gerashchenko M, Gladyshev VN, Dikiy A
published in: Biomolecular NMR assignments
information resource reference: ¹H, ¹³C, and ¹5N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR. Biomol NMR Assign. 2012 Apr; 6(1):103-7.
journal title abbreviation: Biomol NMR Assign
publication date: 2011-09-08T00:00:00
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Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.
PubMed Identifier: 16230358
author list: Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. J Biol Chem. 2005 Dec 16; 280(50):41568-75.
journal title abbreviation: J Biol Chem
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Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.
PubMed Identifier: 16565519
author list: Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem. 2006 May 12; 281(19):13005-13008.
journal title abbreviation: J Biol Chem
publication date: 2006-03-25T00:00:00
year: 2006
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Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.
PubMed Identifier: 15141092
author list: Koc A, Gasch AP, Rutherford JC, Kim HY, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7999-8004.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-05-12T00:00:00
year: 2004
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Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
PubMed Identifier: 15317934
author list: Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12848-53.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-08-18T00:00:00
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The Chlamydomonas genome reveals the evolution of key animal and plant functions.
PubMed Identifier: 17932292
author list: Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR
published in: Science (New York, N.Y.)
information resource reference: The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12; 318(5848):245-50.
journal title abbreviation: Science
publication date: 2007-10-12T00:00:00
year: 2007
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Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases.
PubMed Identifier: 17105189
author list: Kim HY, Fomenko DE, Yoon YE, Gladyshev VN
published in: Biochemistry
information resource reference: Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21; 45(46):13697-704.
journal title abbreviation: Biochemistry
publication date: 2006-11-21T00:00:00
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The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.
PubMed Identifier: 17365173
author list: Labunskyy VM, Hatfield DL, Gladyshev VN
published in: IUBMB life
information resource reference: The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life. 2007 Jan; 59(1):1-5.
journal title abbreviation: IUBMB Life
publication date: 2007-01-01T00:00:00
year: 2007
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Biosynthesis of selenocysteine on its tRNA in eukaryotes.
PubMed Identifier: 17194211
author list: Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL
published in: PLoS biology
information resource reference: Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2007 Jan; 5(1):e4.
journal title abbreviation: PLoS Biol
publication date: 2007-01-01T00:00:00
year: 2007
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Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium.
PubMed Identifier: 12588969
author list: Kumaraswamy E, Carlson BA, Morgan F, Miyoshi K, Robinson GW, Su D, Wang S, Southon E, Tessarollo L, Lee BJ, Gladyshev VN, Hennighausen L, Hatfield DL
published in: Molecular and cellular biology
information resource reference: Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol. 2003 Mar; 23(5):1477-88.
journal title abbreviation: Mol Cell Biol
publication date: 2003-03-01T00:00:00
year: 2003
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A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila.
PubMed Identifier: 18772345
author list: Hirosawa-Takamori M, Ossipov D, Novoselov SV, Turanov AA, Zhang Y, Gladyshev VN, Krol A, Vorbrüggen G, Jäckle H
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. FASEB J. 2009 Jan; 23(1):107-13.
journal title abbreviation: FASEB J
publication date: 2008-09-04T00:00:00
year: 2008
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[Draft macronuclear genome of a ciliate Euplotes crassus].
PubMed Identifier: 22670532
author list: Vinogradov DV, Tsoi OV, Zaika AV, Lobanov AV, Turanov AA, Gladyshev VN, Gel'fand MS
published in: Molekuliarnaia biologiia
information resource reference: [Draft macronuclear genome of a ciliate Euplotes crassus]. Mol Biol (Mosk). 2012 Mar-Apr; 46(2):361-6.
journal title abbreviation: Mol Biol (Mosk)
publication date: 2012-03-01T00:00:00
year: 2012
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type: Document
type: Information Resource

Authorship 992738
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

Authorship 993300
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I).
PubMed Identifier: 28463568
author list: Salinas G, Gao W, Wang Y, Bonilla M, Yu L, Novikov A, Virginio VG, Ferreira HB, Vieites M, Gladyshev VN, Gambino D, Dai S
published in: Antioxidants & redox signaling
information resource reference: The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxid Redox Signal. 2017 Dec 20; 27(18):1491-1504.
journal title abbreviation: Antioxid Redox Signal
publication date: 2017-06-26T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.
PubMed Identifier: 28663583
author list: Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L
published in: Scientific reports
information resource reference: Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P. Sci Rep. 2017 06 29; 7(1):4391.
journal title abbreviation: Sci Rep
publication date: 2017-06-29T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic code supports targeted insertion of two amino acids by one codon.
PubMed Identifier: 19131629
author list: Turanov AA, Lobanov AV, Fomenko DE, Morrison HG, Sogin ML, Klobutcher LA, Hatfield DL, Gladyshev VN
published in: Science (New York, N.Y.)
information resource reference: Genetic code supports targeted insertion of two amino acids by one codon. Science. 2009 Jan 09; 323(5911):259-61.
journal title abbreviation: Science
publication date: 2009-01-09T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast.
PubMed Identifier: 19414602
author list: Kaya A, Karakaya HC, Fomenko DE, Gladyshev VN, Koc A
published in: Molecular and cellular biology
information resource reference: Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Mol Cell Biol. 2009 Jul; 29(13):3665-74.
journal title abbreviation: Mol Cell Biol
publication date: 2009-05-04T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast.
PubMed Identifier: 20799725
author list: Kaya A, Koc A, Lee BC, Fomenko DE, Rederstorff M, Krol A, Lescure A, Gladyshev VN
published in: Biochemistry
information resource reference: Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Biochemistry. 2010 Oct 05; 49(39):8618-25.
journal title abbreviation: Biochemistry
publication date: 2010-09-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 994105
type: Authorship
author rank in publication: 7
linked author: Gladyshev, Vadim
linked information resource: Translation fidelity coevolves with longevity.

Authorship 996413
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.

Translation fidelity coevolves with longevity.
PubMed Identifier: 28707419
author list: Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V
published in: Aging cell
information resource reference: Translation fidelity coevolves with longevity. Aging Cell. 2017 10; 16(5):988-993.
journal title abbreviation: Aging Cell
publication date: 2017-07-13T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.
PubMed Identifier: 28698597
author list: Lee BC, Lee SG, Choo MK, Kim JH, Lee HM, Kim S, Fomenko DE, Kim HY, Park JM, Gladyshev VN
published in: Scientific reports
information resource reference: Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo. Sci Rep. 2017 07 11; 7(1):5119.
journal title abbreviation: Sci Rep
publication date: 2017-07-11T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.
PubMed Identifier: 8650234
author list: Gladyshev VN, Jeang KT, Stadtman TC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6146-51.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-06-11T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family.
PubMed Identifier: 16236027
author list: Novoselov SV, Hua D, Lobanov AV, Gladyshev VN
published in: The Biochemical journal
information resource reference: Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family. Biochem J. 2006 Mar 15; 394(Pt 3):575-9.
journal title abbreviation: Biochem J
publication date: 2006-03-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine incorporation machinery and the role of selenoproteins in development and health.
PubMed Identifier: 16891170
author list: Hatfield DL, Carlson BA, Xu XM, Mix H, Gladyshev VN
published in: Progress in nucleic acid research and molecular biology
information resource reference: Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog Nucleic Acid Res Mol Biol. 2006; 81:97-142.
journal title abbreviation: Prog Nucleic Acid Res Mol Biol
publication date: 2006-01-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis.
PubMed Identifier: 17626042
author list: Zhang Y, Gladyshev VN
published in: Nucleic acids research
information resource reference: High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis. Nucleic Acids Res. 2007; 35(15):4952-63.
journal title abbreviation: Nucleic Acids Res
publication date: 2007-07-11T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.
PubMed Identifier: 19935881
author list: Sengupta A, Carlson BA, Labunskyy VM, Gladyshev VN, Hatfield DL
published in: Biochemistry and cell biology = Biochimie et biologie cellulaire
information resource reference: Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009 Dec; 87(6):953-61.
journal title abbreviation: Biochem Cell Biol
publication date: 2009-12-01T00:00:00
year: 2009
type: Academic Article
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type: Document
type: Information Resource

Analysis and functional prediction of reactive cysteine residues.
PubMed Identifier: 22157013
author list: Marino SM, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Analysis and functional prediction of reactive cysteine residues. J Biol Chem. 2012 Feb 10; 287(7):4419-25.
journal title abbreviation: J Biol Chem
publication date: 2011-12-06T00:00:00
year: 2011
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Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells.
PubMed Identifier: 9792801
author list: Gladyshev VN, Factor VM, Housseau F, Hatfield DL
published in: Biochemical and biophysical research communications
information resource reference: Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):488-93.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1998-10-20T00:00:00
year: 1998
type: Academic Article
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type: Document
type: Information Resource

New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.
PubMed Identifier: 10567350
author list: Kryukov GV, Kryukov VM, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999 Nov 26; 274(48):33888-97.
journal title abbreviation: J Biol Chem
publication date: 1999-11-26T00:00:00
year: 1999
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type: Information Resource

High-throughput identification of catalytic redox-active cysteine residues.
PubMed Identifier: 17234949
author list: Fomenko DE, Xing W, Adair BM, Thomas DJ, Gladyshev VN
published in: Science (New York, N.Y.)
information resource reference: High-throughput identification of catalytic redox-active cysteine residues. Science. 2007 Jan 19; 315(5810):387-9.
journal title abbreviation: Science
publication date: 2007-01-19T00:00:00
year: 2007
type: Academic Article
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type: Information Resource

Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins.
PubMed Identifier: 19747065
author list: Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 01; 12(7):839-49.
journal title abbreviation: Antioxid Redox Signal
publication date: 2010-04-01T00:00:00
year: 2010
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type: Document
type: Information Resource

CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.
PubMed Identifier: 20018845
author list: Gerashchenko MV, Su D, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem. 2010 Feb 12; 285(7):4595-602.
journal title abbreviation: J Biol Chem
publication date: 2009-12-14T00:00:00
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Dietary selenium affects host selenoproteome expression by influencing the gut microbiota.
PubMed Identifier: 21493887
author list: Kasaikina MV, Kravtsova MA, Lee BC, Seravalli J, Peterson DA, Walter J, Legge R, Benson AK, Hatfield DL, Gladyshev VN
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J. 2011 Jul; 25(7):2492-9.
journal title abbreviation: FASEB J
publication date: 2011-04-14T00:00:00
year: 2011
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type: Document
type: Information Resource

Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.
PubMed Identifier: 21835919
author list: Yim SH, Kim YJ, Oh SY, Fujii J, Zhang Y, Gladyshev VN, Rhee SG
published in: The Journal of biological chemistry
information resource reference: Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011 Nov 11; 286(45):39002-12.
journal title abbreviation: J Biol Chem
publication date: 2011-08-11T00:00:00
year: 2011
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type: Document
type: Information Resource

HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.
PubMed Identifier: 22348009
author list: Naranjo-Suarez S, Carlson BA, Tsuji PA, Yoo MH, Gladyshev VN, Hatfield DL
published in: PloS one
information resource reference: HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS One. 2012; 7(2):e30470.
journal title abbreviation: PLoS One
publication date: 2012-02-13T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1006653
type: Authorship
author rank in publication: 2
linked author: Gladyshev, Vadim
linked information resource: Molecular signatures of longevity: Insights from cross-species comparative studies.

Authorship 1002697
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes.

Molecular signatures of longevity: Insights from cross-species comparative studies.
PubMed Identifier: 28800931
author list: Ma S, Gladyshev VN
published in: Seminars in cell & developmental biology
information resource reference: Molecular signatures of longevity: Insights from cross-species comparative studies. Semin Cell Dev Biol. 2017 10; 70:190-203.
journal title abbreviation: Semin Cell Dev Biol
publication date: 2017-08-08T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes.
PubMed Identifier: 28765365
author list: Kaya A, Mariotti M, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8678-8680.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2017-08-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Functions and evolution of selenoprotein methionine sulfoxide reductases.
PubMed Identifier: 19406207
author list: Lee BC, Dikiy A, Kim HY, Gladyshev VN
published in: Biochimica et biophysica acta
information resource reference: Functions and evolution of selenoprotein methionine sulfoxide reductases. Biochim Biophys Acta. 2009 Nov; 1790(11):1471-7.
journal title abbreviation: Biochim Biophys Acta
publication date: 2009-05-04T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase.
PubMed Identifier: 21210868
author list: Kim MJ, Lee BC, Jeong J, Lee KJ, Hwang KY, Gladyshev VN, Kim HY
published in: Molecular microbiology
information resource reference: Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase. Mol Microbiol. 2011 Mar; 79(5):1194-203.
journal title abbreviation: Mol Microbiol
publication date: 2011-01-06T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1008661
type: Authorship
author rank in publication: 3
linked author: Gladyshev, Vadim
linked information resource: A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.
PubMed Identifier: 28874059
author list: Golubev A, Hanson AD, Gladyshev VN
published in: Antioxidants & redox signaling
information resource reference: A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging. Antioxid Redox Signal. 2018 10 01; 29(10):1003-1017.
journal title abbreviation: Antioxid Redox Signal
publication date: 2017-10-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis.
PubMed Identifier: 8626495
author list: Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD
published in: The Journal of biological chemistry
information resource reference: Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis. J Biol Chem. 1996 Apr 05; 271(14):8095-100.
journal title abbreviation: J Biol Chem
publication date: 1996-04-05T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of molybdopterins in molybdenum- and selenium-containing enzymes.
PubMed Identifier: 8722123
author list: Gladyshev VN, Lecchi P
published in: BioFactors (Oxford, England)
information resource reference: Identification of molybdopterins in molybdenum- and selenium-containing enzymes. Biofactors. 1995-1996; 5(2):93-7.
journal title abbreviation: Biofactors
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1011041
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

Authorship 1011495
type: Authorship
author rank in publication: 6
linked author: Gladyshev, Vadim
linked information resource: Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.
PubMed Identifier: 28917052
author list: Tarrago L, Oheix E, Péterfi Z, Gladyshev VN
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity. Methods Mol Biol. 2018; 1661:285-299.
journal title abbreviation: Methods Mol Biol
publication date: 2018-01-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.
PubMed Identifier: 28917036
author list: Carlson BA, Lee BJ, Tsuji PA, Copeland PR, Schweizer U, Gladyshev VN, Hatfield DL
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing. Methods Mol Biol. 2018; 1661:43-60.
journal title abbreviation: Methods Mol Biol
publication date: 2018-01-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Identity and functions of CxxC-derived motifs.
PubMed Identifier: 14503871
author list: Fomenko DE, Gladyshev VN
published in: Biochemistry
information resource reference: Identity and functions of CxxC-derived motifs. Biochemistry. 2003 Sep 30; 42(38):11214-25.
journal title abbreviation: Biochemistry
publication date: 2003-09-30T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1.
PubMed Identifier: 15379556
author list: Su D, Gladyshev VN
published in: Biochemistry
information resource reference: Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1. Biochemistry. 2004 Sep 28; 43(38):12177-88.
journal title abbreviation: Biochemistry
publication date: 2004-09-28T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution.
PubMed Identifier: 15924425
author list: Kim HY, Gladyshev VN
published in: Biochemistry
information resource reference: Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution. Biochemistry. 2005 Jun 07; 44(22):8059-67.
journal title abbreviation: Biochemistry
publication date: 2005-06-07T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases.
PubMed Identifier: 16542431
author list: Kim HY, Gladyshev VN
published in: BMC molecular biology
information resource reference: Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. BMC Mol Biol. 2006 Mar 16; 7:11.
journal title abbreviation: BMC Mol Biol
publication date: 2006-03-16T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
PubMed Identifier: 18505275
author list: Le DT, Liang X, Fomenko DE, Raza AS, Chong CK, Carlson BA, Hatfield DL, Gladyshev VN
published in: Biochemistry
information resource reference: Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Biochemistry. 2008 Jun 24; 47(25):6685-94.
journal title abbreviation: Biochemistry
publication date: 2008-06-24T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases.
PubMed Identifier: 18648218
author list: Fomenko DE, Marino SM, Gladyshev VN
published in: Molecules and cells
information resource reference: Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases. Mol Cells. 2008 Sep 30; 26(3):228-35.
journal title abbreviation: Mol Cells
publication date: 2008-07-23T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets.
PubMed Identifier: 20536427
author list: Turanov AA, Kehr S, Marino SM, Yoo MH, Carlson BA, Hatfield DL, Gladyshev VN
published in: The Biochemical journal
information resource reference: Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Biochem J. 2010 Sep 01; 430(2):285-93.
journal title abbreviation: Biochem J
publication date: 2010-09-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.
PubMed Identifier: 21217751
author list: Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP
published in: Nature methods
information resource reference: Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64.
journal title abbreviation: Nat Methods
publication date: 2011-01-09T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy.
PubMed Identifier: 21823615
author list: Lee BC, Fomenko DE, Gladyshev VN
published in: ACS chemical biology
information resource reference: Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy. ACS Chem Biol. 2011 Oct 21; 6(10):1029-35.
journal title abbreviation: ACS Chem Biol
publication date: 2011-08-22T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PubMed Identifier: 22479358
author list: Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
published in: PloS one
information resource reference: Composition and evolution of the vertebrate and mammalian selenoproteomes. PLoS One. 2012; 7(3):e33066.
journal title abbreviation: PLoS One
publication date: 2012-03-30T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1016926
type: Authorship
author rank in publication: 4
linked author: Gladyshev, Vadim
linked information resource: Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.

Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.
PubMed Identifier: 28986131
author list: Kim KY, Kwak GH, Singh MP, Gladyshev VN, Kim HY
published in: Archives of biochemistry and biophysics
information resource reference: Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage. Arch Biochem Biophys. 2017 11 15; 634:69-75.
journal title abbreviation: Arch Biochem Biophys
publication date: 2017-10-03T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme.
PubMed Identifier: 8722124
author list: Tamura T, Gladyshev V, Liu SY, Stadtman TC
published in: BioFactors (Oxford, England)
information resource reference: The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme. Biofactors. 1995-1996; 5(2):99-102.
journal title abbreviation: Biofactors
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis.
PubMed Identifier: 17346238
author list: Xu XM, Carlson BA, Irons R, Mix H, Zhong N, Gladyshev VN, Hatfield DL
published in: The Biochemical journal
information resource reference: Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J. 2007 May 15; 404(1):115-20.
journal title abbreviation: Biochem J
publication date: 2007-05-15T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Redox regulation of cell signaling by thioredoxin reductases.
PubMed Identifier: 11898437
author list: Sun QA, Gladyshev VN
published in: Methods in enzymology
information resource reference: Redox regulation of cell signaling by thioredoxin reductases. Methods Enzymol. 2002; 347:451-61.
journal title abbreviation: Methods Enzymol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions.
PubMed Identifier: 12538901
author list: Novoselov SV, Gladyshev VN
published in: Protein science : a publication of the Protein Society
information resource reference: Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions. Protein Sci. 2003 Feb; 12(2):372-8.
journal title abbreviation: Protein Sci
publication date: 2003-02-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec.
PubMed Identifier: 12869703
author list: Rao M, Carlson BA, Novoselov SV, Weeks DP, Gladyshev VN, Hatfield DL
published in: RNA (New York, N.Y.)
information resource reference: Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec. RNA. 2003 Aug; 9(8):923-30.
journal title abbreviation: RNA
publication date: 2003-08-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals.
PubMed Identifier: 18032379
author list: Zhang Y, Zhou Y, Schweizer U, Savaskan NE, Hua D, Kipnis J, Hatfield DL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem. 2008 Jan 25; 283(4):2427-38.
journal title abbreviation: J Biol Chem
publication date: 2007-11-21T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis.
PubMed Identifier: 18156471
author list: Lobanov AV, Hatfield DL, Gladyshev VN
published in: Protein science : a publication of the Protein Society
information resource reference: Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci. 2008 Jan; 17(1):176-82.
journal title abbreviation: Protein Sci
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen.
PubMed Identifier: 18167539
author list: Ridge PG, Zhang Y, Gladyshev VN
published in: PloS one
information resource reference: Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One. 2008 Jan 02; 3(1):e1378.
journal title abbreviation: PLoS One
publication date: 2008-01-02T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project.
PubMed Identifier: 18551170
author list: Zhang Y, Gladyshev VN
published in: PLoS genetics
information resource reference: Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet. 2008 Jun 13; 4(6):e1000095.
journal title abbreviation: PLoS Genet
publication date: 2008-06-13T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization.
PubMed Identifier: 19208259
author list: Zhang Y, Rodionov DA, Gelfand MS, Gladyshev VN
published in: BMC genomics
information resource reference: Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics. 2009 Feb 10; 10:78.
journal title abbreviation: BMC Genomics
publication date: 2009-02-10T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.
PubMed Identifier: 19769463
author list: Yoo MH, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL
published in: Antioxidants & redox signaling
information resource reference: Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxid Redox Signal. 2010 Apr 01; 12(7):819-27.
journal title abbreviation: Antioxid Redox Signal
publication date: 2010-04-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of protein targets of mammalian thioredoxin reductases.
PubMed Identifier: 20609914
author list: Turanov AA, Hatfield DL, Gladyshev VN
published in: Methods in enzymology
information resource reference: Characterization of protein targets of mammalian thioredoxin reductases. Methods Enzymol. 2010; 474:245-54.
journal title abbreviation: Methods Enzymol
publication date: 2010-06-20T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins.
PubMed Identifier: 23088625
author list: Liang X, Kaya A, Zhang Y, Le DT, Hua D, Gladyshev VN
published in: BMC biochemistry
information resource reference: Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins. BMC Biochem. 2012 Oct 23; 13:21.
journal title abbreviation: BMC Biochem
publication date: 2012-10-23T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1025247
type: Authorship
author rank in publication: 10
linked author: Gladyshev, Vadim
linked information resource: Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.
PubMed Identifier: 29107591
author list: Lee SG, Mikhalchenko AE, Yim SH, Lobanov AV, Park JK, Choi KH, Bronson RT, Lee CK, Park TJ, Gladyshev VN
published in: Stem cell reports
information resource reference: Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera. Stem Cell Reports. 2017 11 14; 9(5):1706-1720.
journal title abbreviation: Stem Cell Reports
publication date: 2017-10-26T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif.
PubMed Identifier: 17715293
author list: Shchedrina VA, Novoselov SV, Malinouski MY, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13919-24.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-08-22T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA.
PubMed Identifier: 11340175
author list: Moustafa ME, Carlson BA, El-Saadani MA, Kryukov GV, Sun QA, Harney JW, Hill KE, Combs GF, Feigenbaum L, Mansur DB, Burk RF, Berry MJ, Diamond AM, Lee BJ, Gladyshev VN, Hatfield DL
published in: Molecular and cellular biology
information resource reference: Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Mol Cell Biol. 2001 Jun; 21(11):3840-52.
journal title abbreviation: Mol Cell Biol
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.
PubMed Identifier: 17928294
author list: Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A
published in: The Journal of biological chemistry
information resource reference: Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21; 282(51):37036-44.
journal title abbreviation: J Biol Chem
publication date: 2007-10-10T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1027520
type: Authorship
author rank in publication: 25
linked author: Gladyshev, Vadim
linked information resource: Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives.

Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives.
PubMed Identifier: 29149296
author list: Tang Q, Gu Y, Zhou X, Jin L, Guan J, Liu R, Li J, Long K, Tian S, Che T, Hu S, Liang Y, Yang X, Tao X, Zhong Z, Wang G, Chen X, Li D, Ma J, Wang X, Mai M, Jiang A, Luo X, Lv X, Gladyshev VN, Li X, Li M
published in: GigaScience
information resource reference: Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives. Gigascience. 2017 12 01; 6(12):1-9.
journal title abbreviation: Gigascience
publication date: 2017-12-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Analysis of selenocysteine-containing proteins.
PubMed Identifier: 18429173
author list: Gladyshev VN, Hatfield DL
published in: Current protocols in protein science
information resource reference: Analysis of selenocysteine-containing proteins. Curr Protoc Protein Sci. 2001 May; Chapter 3:Unit 3.8.
journal title abbreviation: Curr Protoc Protein Sci
publication date: 2001-05-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins mediate T cell immunity through an antioxidant mechanism.
PubMed Identifier: 18487203
author list: Shrimali RK, Irons RD, Carlson BA, Sano Y, Gladyshev VN, Park JM, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem. 2008 Jul 18; 283(29):20181-5.
journal title abbreviation: J Biol Chem
publication date: 2008-05-16T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.
PubMed Identifier: 11929995
author list: Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4245-50.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2002-04-02T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
PubMed Identifier: 12145281
author list: Kumar RA, Koc A, Cerny RL, Gladyshev VN
published in: The Journal of biological chemistry
information resource reference: Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase. J Biol Chem. 2002 Oct 04; 277(40):37527-35.
journal title abbreviation: J Biol Chem
publication date: 2002-07-26T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.
PubMed Identifier: 19805165
author list: Jin BY, Sartoretto JL, Gladyshev VN, Michel T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17343-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2009-09-25T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis.
PubMed Identifier: 20605785
author list: Aachmann FL, Sal LS, Kim HY, Marino SM, Gladyshev VN, Dikiy A
published in: The Journal of biological chemistry
information resource reference: Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis. J Biol Chem. 2010 Oct 22; 285(43):33315-33323.
journal title abbreviation: J Biol Chem
publication date: 2010-07-05T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.
PubMed Identifier: 21051543
author list: Bonilla M, Denicola A, Marino SM, Gladyshev VN, Salinas G
published in: The Journal of biological chemistry
information resource reference: Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem. 2011 Feb 18; 286(7):4959-67.
journal title abbreviation: J Biol Chem
publication date: 2010-11-04T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

The biological significance of methionine sulfoxide stereochemistry.
PubMed Identifier: 21075204
author list: Lee BC, Gladyshev VN
published in: Free radical biology & medicine
information resource reference: The biological significance of methionine sulfoxide stereochemistry. Free Radic Biol Med. 2011 Jan 15; 50(2):221-7.
journal title abbreviation: Free Radic Biol Med
publication date: 2010-11-11T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes.
PubMed Identifier: 15797911
author list: Zhang Y, Gladyshev VN
published in: Bioinformatics (Oxford, England)
information resource reference: An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Bioinformatics. 2005 Jun 01; 21(11):2580-9.
journal title abbreviation: Bioinformatics
publication date: 2005-03-29T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR.
PubMed Identifier: 17468436
author list: Yoo MH, Xu XM, Turanov AA, Carlson BA, Gladyshev VN, Hatfield DL
published in: RNA (New York, N.Y.)
information resource reference: A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR. RNA. 2007 Jun; 13(6):921-9.
journal title abbreviation: RNA
publication date: 2007-04-27T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism.
PubMed Identifier: 22594686
author list: Tobe R, Yoo MH, Fradejas N, Carlson BA, Calvo S, Gladyshev VN, Hatfield DL
published in: The Biochemical journal
information resource reference: Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism. Biochem J. 2012 Aug 01; 445(3):423-30.
journal title abbreviation: Biochem J
publication date: 2012-08-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Recharging oxidative protein repair: catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates.
PubMed Identifier: 23157290
author list: Tarrago L, Gladyshev VN
published in: Biochemistry. Biokhimiia
information resource reference: Recharging oxidative protein repair: catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates. Biochemistry (Mosc). 2012 Oct; 77(10):1097-107.
journal title abbreviation: Biochemistry (Mosc)
publication date: 2012-10-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.
PubMed Identifier: 17848557
author list: Carlson BA, Moustafa ME, Sengupta A, Schweizer U, Shrimali R, Rao M, Zhong N, Wang S, Feigenbaum L, Lee BJ, Gladyshev VN, Hatfield DL
published in: The Journal of biological chemistry
information resource reference: Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J Biol Chem. 2007 Nov 09; 282(45):32591-602.
journal title abbreviation: J Biol Chem
publication date: 2007-09-11T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait.
PubMed Identifier: 18510720
author list: Zhang Y, Turanov AA, Hatfield DL, Gladyshev VN
published in: BMC genomics
information resource reference: In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait. BMC Genomics. 2008 May 29; 9:251.
journal title abbreviation: BMC Genomics
publication date: 2008-05-29T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Recode-2: new design, new search tools, and many more genes.
PubMed Identifier: 19783826
author list: Bekaert M, Firth AE, Zhang Y, Gladyshev VN, Atkins JF, Baranov PV
published in: Nucleic acids research
information resource reference: Recode-2: new design, new search tools, and many more genes. Nucleic Acids Res. 2010 Jan; 38(Database issue):D69-74.
journal title abbreviation: Nucleic Acids Res
publication date: 2009-09-25T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.
PubMed Identifier: 20388823
author list: Irons R, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, Davis CD
published in: Cancer prevention research (Philadelphia, Pa.)
information resource reference: Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prev Res (Phila). 2010 May; 3(5):630-9.
journal title abbreviation: Cancer Prev Res (Phila)
publication date: 2010-04-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced reliance on the trace element selenium during evolution of mammals.
PubMed Identifier: 18377657
author list: Lobanov AV, Hatfield DL, Gladyshev VN
published in: Genome biology
information resource reference: Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol. 2008; 9(3):R62.
journal title abbreviation: Genome Biol
publication date: 2008-03-31T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Dual functions of codons in the genetic code.
PubMed Identifier: 20446809
author list: Lobanov AV, Turanov AA, Hatfield DL, Gladyshev VN
published in: Critical reviews in biochemistry and molecular biology
information resource reference: Dual functions of codons in the genetic code. Crit Rev Biochem Mol Biol. 2010 Aug; 45(4):257-65.
journal title abbreviation: Crit Rev Biochem Mol Biol
publication date: 2010-08-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.
PubMed Identifier: 22536349
author list: Ross F, Hernández P, Porcal W, López GV, Cerecetto H, González M, Basika T, Carmona C, Fló M, Maggioli G, Bonilla M, Gladyshev VN, Boiani M, Salinas G
published in: PloS one
information resource reference: Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites. PLoS One. 2012; 7(4):e35033.
journal title abbreviation: PLoS One
publication date: 2012-04-20T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation.
PubMed Identifier: 19854201
author list: Marino SM, Gladyshev VN
published in: Journal of molecular biology
information resource reference: Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation. J Mol Biol. 2010 Jan 29; 395(4):844-59.
journal title abbreviation: J Mol Biol
publication date: 2009-10-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1037095
type: Authorship
author rank in publication: 11
linked author: Gladyshev, Vadim
linked information resource: AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.
PubMed Identifier: 29310120
author list: Yordanova MM, Loughran G, Zhdanov AV, Mariotti M, Kiniry SJ, O'Connor PBF, Andreev DE, Tzani I, Saffert P, Michel AM, Gladyshev VN, Papkovsky DB, Atkins JF, Baranov PV
published in: Nature
information resource reference: AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation. Nature. 2018 01 18; 553(7688):356-360.
journal title abbreviation: Nature
publication date: 2018-01-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenoproteins are essential for proper keratinocyte function and skin development.
PubMed Identifier: 20805887
author list: Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL
published in: PloS one
information resource reference: Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010 Aug 18; 5(8):e12249.
journal title abbreviation: PLoS One
publication date: 2010-08-18T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74.
PubMed Identifier: 21185009
author list: Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S
published in: American journal of human genetics
information resource reference: Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet. 2011 Jan 07; 88(1):19-29.
journal title abbreviation: Am J Hum Genet
publication date: 2010-12-23T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

The naked mole rat genome: understanding aging through genome analysis.
PubMed Identifier: 22199030
author list: Gladyshev VN, Zhang G, Wang J
published in: Aging
information resource reference: The naked mole rat genome: understanding aging through genome analysis. Aging (Albany NY). 2011 Dec; 3(12):1124.
journal title abbreviation: Aging (Albany NY)
publication date: 2011-12-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1039198
type: Authorship
author rank in publication: 8
linked author: Gladyshev, Vadim
linked information resource: Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.
PubMed Identifier: 29343716
author list: Lee BC, Lee HM, Kim S, Avanesov AS, Lee A, Chun BH, Vorbruggen G, Gladyshev VN
published in: Scientific reports
information resource reference: Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner. Sci Rep. 2018 01 17; 8(1):1010.
journal title abbreviation: Sci Rep
publication date: 2018-01-17T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
PubMed Identifier: 17971875
author list: Yoo MH, Xu XM, Carlson BA, Patterson AD, Gladyshev VN, Hatfield DL
published in: PloS one
information resource reference: Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS One. 2007 Oct 31; 2(10):e1112.
journal title abbreviation: PLoS One
publication date: 2007-10-31T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Genome sequencing reveals insights into physiology and longevity of the naked mole rat.
PubMed Identifier: 21993625
author list: Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN
published in: Nature
information resource reference: Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011 Oct 12; 479(7372):223-7.
journal title abbreviation: Nature
publication date: 2011-10-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.
PubMed Identifier: 22791808
author list: Carlson BA, Yoo MH, Tobe R, Mueller C, Naranjo-Suarez S, Hoffmann VJ, Gladyshev VN, Hatfield DL
published in: Carcinogenesis
information resource reference: Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis. 2012 Sep; 33(9):1806-13.
journal title abbreviation: Carcinogenesis
publication date: 2012-07-12T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.
PubMed Identifier: 11280803
author list: Hu YJ, Korotkov KV, Mehta R, Hatfield DL, Rotimi CN, Luke A, Prewitt TE, Cooper RS, Stock W, Vokes EE, Dolan ME, Gladyshev VN, Diamond AM
published in: Cancer research
information resource reference: Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Res. 2001 Mar 01; 61(5):2307-10.
journal title abbreviation: Cancer Res
publication date: 2001-03-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins.
PubMed Identifier: 11568444
author list: Gladyshev VN, Kryukov GV
published in: BioFactors (Oxford, England)
information resource reference: Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins. Biofactors. 2001; 14(1-4):87-92.
journal title abbreviation: Biofactors
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.
PubMed Identifier: 14710190
author list: Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol A, Gladyshev VN, Guigó R
published in: EMBO reports
information resource reference: Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep. 2004 Jan; 5(1):71-7.
journal title abbreviation: EMBO Rep
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.
PubMed Identifier: 16914442
author list: Lobanov AV, Gromer S, Salinas G, Gladyshev VN
published in: Nucleic acids research
information resource reference: Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res. 2006; 34(14):4012-24.
journal title abbreviation: Nucleic Acids Res
publication date: 2006-08-16T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme.
PubMed Identifier: 9481877
author list: Klyachko NL, Vakula SV, Gladyshev VN, Tishkov VI, Levashov AV
published in: Biochemistry. Biokhimiia
information resource reference: Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. Biochemistry (Mosc). 1997 Dec; 62(12):1439-43.
journal title abbreviation: Biochemistry (Mosc)
publication date: 1997-12-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource