Dr. Perrella is an Associate Professor of Medicine at Harvard Medical School and an Associate Physician in Pulmonary and Critical Care, and Newborn Medicine, at Brigham and Women’s Hospital in Boston, MA. Dr. Perrella has received a number of honors and awards throughout his career including the Internal Medicine Outstanding Achievement Award at the Mayo Graduate School of Medicine; Mayo Foundation Scholar in the Division of Thoracic Diseases and Internal Medicine; Mayo Alumni Association’s Donald C. Balfour Award for Meritorious Research; the Mayo Foundation Clinician Scholar Award; and election into the American Society for Clinical Investigation. Dr. Perrella is a National Institutes of Health (NIH) funded investigator, and he is devoted to the scientific peer review process including his involvement in serving on NIH study sections and his appointment as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology. The Perrella laboratory is interested in: 1) The regulation and biology of genes important for the modulation of inflammation and oxidative stress in systemic disease processes. A gene of particular interest is heme oxygenase-1, and its downstream product carbon monoxide, in mediating the pathobiology of sepsis and acute lung injury. 2) The regulation and biology of genes selectively expressed in muscle cells (smooth or striated). A recent focus has been the striated preferentially expressed gene (Speg) and its role in fetal heart development and function. 3) The commitment and differentiation of progenitor cells during the evolution of disease processes. The ultimate goal is to develop novel cell-based strategies for the treatment of cardiopulmonary and vascular diseases for patients of all ages, from premature infants to adults.
Huntoon V, Widrick JJ, Sanchez C, Rosen SM, Kutchukian C, Cao S, Pierson CR, Liu X, Perrella MA, Beggs AH, Jacquemond V, Agrawal PB
SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling. Hum Mol Genet. 2018 05 01; 27(9):1608-1617.
SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling.
Wiesel P, Patel AP, Carvajal IM, Wang ZY, Pellacani A, Maemura K, DiFonzo N, Rennke HG, Layne MD, Yet SF, Lee ME, Perrella MA
Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res. 2001 May 25; 88(10):1088-94.
Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice.
Yoshizumi M, Perrella MA, Burnett JC, Lee ME
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res. 1993 Jul; 73(1):205-9.
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.
Kwon MY, Hwang N, Park YJ, Perrella MA, Chung SW
NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation. Oncotarget. 2018 Feb 27; 9(16):12671-12681.
NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation.
Pellacani A, Wiesel P, Sharma A, Foster LC, Huggins GS, Yet SF, Perrella MA
Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Circ Res. 1998 Aug 24; 83(4):396-403.
Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1.
Temizer DH, Yoshizumi M, Perrella MA, Susanni EE, Quertermous T, Lee ME
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells. J Biol Chem. 1992 Dec 05; 267(34):24892-6.
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells.
Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonists
Tan MS, Tsai JC, Lee YJ, Chen HC, Shin SJ, Lai YH, Perrella MA, Bianchi C, Higashiyama S, Endege W
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators. Kidney Int. 1994 Sep; 46(3):690-5.
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators.
Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC
Natriuretic peptide system in human heart failure. Circulation. 1993 Sep; 88(3):1004-9.
Natriuretic peptide system in human heart failure.
Tsai JC, Wang H, Perrella MA, Yoshizumi M, Sibinga NE, Tan LC, Haber E, Chang TH, Schlegel R, Lee ME
Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest. 1996 Jan 01; 97(1):146-53.
Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.
Chen YH, Layne MD, Watanabe M, Yet SF, Perrella MA
Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells. J Biol Chem. 2001 Dec 14; 276(50):47658-63.
Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells.
Layne MD, Yet SF, Maemura K, Hsieh CM, Liu X, Ith B, Lee ME, Perrella MA
Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells. Circ Res. 2002 Apr 05; 90(6):728-36.
Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case. J Am Soc Echocardiogr. 1991 Sep-Oct; 4(5):499-502.
Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case.
Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC
Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15; 418(1):103-12.
Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.
Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD
Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Am J Pathol. 2009 Mar; 174(3):818-28.
Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.
Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009 Feb; 19(2):31-7.
Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility.
Morita T, Perrella MA, Lee ME, Kourembanas S
Proceedings of the National Academy of Sciences of the United States of America
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1475-9.
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
Perrella MA, Mäki T, Prasad S, Pimental D, Singh K, Takahashi N, Yoshizumi M, Alali A, Higashiyama S, Kelly RA
Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes. J Biol Chem. 1994 Oct 28; 269(43):27045-50.
Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.
Perrella MA, Hsieh CM, Lee WS, Shieh S, Tsai JC, Patterson C, Lowenstein CJ, Long NC, Haber E, Shore S, Lee ME
Arrest of endotoxin-induced hypotension by transforming growth factor beta1. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2054-9.
Arrest of endotoxin-induced hypotension by transforming growth factor beta1.
Chung SW, Chen YH, Yet SF, Layne MD, Perrella MA
Journal of immunology (Baltimore, Md. : 1950)
Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages. J Immunol. 2006 Feb 15; 176(4):2414-20.
Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages.
Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA
Cellular and molecular biology (Noisy-le-Grand, France)
Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 03; 51(5):513-20.
Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels.
Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA
Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol. 2018 10; 104(4):677-689.
Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis.
Liu X, Pachori AS, Ward CA, Davis JP, Gnecchi M, Kong D, Zhang L, Murduck J, Yet SF, Perrella MA, Pratt RE, Dzau VJ, Melo LG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. FASEB J. 2006 Feb; 20(2):207-16.
Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.
Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA
High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008 Mar 05; 582(5):810-4.
High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.
Shu C, Huang H, Xu Y, Rota M, Sorrentino A, Peng Y, Padera RF, Huntoon V, Agrawal PB, Liu X, Perrella MA
Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure. Front Physiol. 2018; 9:863.
Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure.
Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, Lee ME
Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6369-73.
Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.
Hung CC, Liu X, Kwon MY, Kang YH, Chung SW, Perrella MA
American journal of physiology. Lung cellular and molecular physiology
Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L870-9.
Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression.
Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
American journal of respiratory cell and molecular biology
Heme oxygenase-1: a multifaceted triple-threat molecule. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):137.
Heme oxygenase-1: a multifaceted triple-threat molecule.
Arkonac BM, Foster LC, Sibinga NE, Patterson C, Lai K, Tsai JC, Lee ME, Perrella MA, Haber E
Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells. J Biol Chem. 1998 Feb 20; 273(8):4400-5.
Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells.
Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA, Haber E, Lee ME
Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. J Biol Chem. 1996 Apr 26; 271(17):10194-9.
Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.
Hall SR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, Liu X, Perrella MA
Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013 Feb; 31(2):397-407.
Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils.
Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem. 2000 Nov 24; 275(47):36847-51.
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.
Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, Lee ME
Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem. 1994 May 20; 269(20):14595-600.
Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.
Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 12 06; 3(23).
A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO
Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. Am J Respir Cell Mol Biol. 2019 06; 60(6):659-666.
Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.
O'Murchu B, Miller VM, Perrella MA, Burnett JC
Increased production of nitric oxide in coronary arteries during congestive heart failure. J Clin Invest. 1994 Jan; 93(1):165-71.
Increased production of nitric oxide in coronary arteries during congestive heart failure.
Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME
Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Aug; 15(10):1774-6.
Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice.
Layne MD, Patel A, Chen YH, Rebel VI, Carvajal IM, Pellacani A, Ith B, Zhao D, Schreiber BM, Yet SF, Lee ME, Storch J, Perrella MA
Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Dec; 15(14):2733-5.
Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice.
Perrella MA, Margulies KB, Wei CM, Aarhus LL, Heublein DM, Burnett JC
Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs. J Clin Invest. 1991 May; 87(5):1649-55.
Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs.
Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M
PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 01; 176(1):275-83.
PU.1 regulates cathepsin S expression in professional APCs.
Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC
Increased endothelin in experimental heart failure. Circulation. 1990 Dec; 82(6):2226-30.
Increased endothelin in experimental heart failure.
Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA
Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One. 2010 May 14; 5(5):e10656.
Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.
Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J
European journal of clinical investigation
Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13.
Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.
Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S
Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831.
Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways.
Mary Ellen Avery Associate Professor of Pediatrics in the Field of Newborn Medicine
Associate Professor of Population Medicine
Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO
Biobanking and cryopreservation of human lung explants for omic analysis. Eur Respir J. 2020 01; 55(1).
Biobanking and cryopreservation of human lung explants for omic analysis.
Hou M, Han J, Li G, Kwon MY, Jiang J, Emani S, Taglauer ES, Park JA, Choi EB, Vodnala M, Fong YW, Emani SM, Rosas IO, Perrella MA, Liu X
Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020 02 13; 11(1):55.
Multipotency of mouse trophoblast stem cells.
Kwon MY, Hwang N, Back SH, Lee SJ, Perrella MA, Chung SW
Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions. FEBS J. 2020 05; 287(10):2055-2069.
Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions.
Kwon MY, Ghanta S, Ng J, Tsoyi K, Lederer JA, Bronson RT, El-Chemaly S, Chung SW, Liu X, Perrella MA
Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis. Crit Care Med. 2020 05; 48(5):e409-e417.
Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial Infection
Shrestha S, Cho W, Stump B, Imani J, Lamattina AM, Louis PH, Pazzanese J, Rosas IO, Visner G, Perrella MA, El-Chemaly S
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 07 31; 26(1):75.
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
Ng J, Guo F, Marneth AE, Ghanta S, Kwon MY, Keegan J, Liu X, Wright KT, Kamaz B, Cahill LA, Mullally A, Perrella MA, Lederer JA
Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis. Blood Adv. 2020 10 13; 4(19):4965-4979.
Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis.
Kwon MY, Ghanta S, Ng J, Castano AP, Han J, Ith B, Lederer JA, El-Chemaly S, Chung SW, Liu X, Perrella MA
Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis. J Leukoc Biol. 2021 10; 110(4):711-722.
Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.
Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO
American journal of respiratory and critical care medicine
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 08 01; 204(3):312-325.
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Methods in molecular biology (Clifton, N.J.)
Induction of Sepsis Via Fibrin Clot Implantation. Methods Mol Biol. 2021; 2321:17-25.
Induction of Sepsis Via Fibrin Clot Implantation.
Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA
Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation. FEBS J. 2022 01; 289(2):417-435.
Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Han J, Li G, Hou M, Ng J, Kwon MY, Xiong K, Liang X, Taglauer E, Shi Y, Mitsialis SA, Kourembanas S, El-Chemaly S, Lederer JA, Rosas IO, Perrella MA, Liu X
Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice. Stem Cell Res Ther. 2021 08 30; 12(1):487.
Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice.
Imani J, Liu K, Cui Y, Assaker JP, Han J, Ghosh AJ, Ng J, Shrestha S, Lamattina AM, Louis PH, Hentschel A, Esposito AJ, Rosas IO, Liu X, Perrella MA, Azzi J, Visner G, El-Chemaly S
Blocking hyaluronan synthesis alleviates acute lung allograft rejection. JCI Insight. 2021 11 22; 6(22).
Blocking hyaluronan synthesis alleviates acute lung allograft rejection.
Ng J, Pacheco-Rodriguez G, Begley L, Huang YJ, Poli S, Perrella MA, Rosas IO, Moss J, El-Chemaly S
The lung microbiome in end-stage Lymphangioleiomyomatosis. Respir Res. 2021 Oct 26; 22(1):277.
The lung microbiome in end-stage Lymphangioleiomyomatosis.
Ackers GK, Perrella M, Holt JM, Denisov I, Huang Y
Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues. Biochemistry. 1997 Sep 09; 36(36):10822-9.
Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues.
Aymonnier K, Ng J, Fredenburgh LE, Zambrano-Vera K, Münzer P, Gutch S, Fukui S, Desjardins M, Subramaniam M, Baron RM, Raby BA, Perrella MA, Lederer JA, Wagner DD
Inflammasome activation in neutrophils of patients with severe COVID-19. Blood Adv. 2022 04 12; 6(7):2001-2013.
Inflammasome activation in neutrophils of patients with severe COVID-19.
Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847.
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Shrestha S, Lamattina A, Pacheco-Rodriguez G, Ng J, Liu X, Sonawane A, Imani J, Qiu W, Kosmas K, Louis P, Hentschel A, Steagall WK, Onishi R, Christou H, Henske EP, Glass K, Perrella MA, Moss J, Tantisira K, El-Chemaly S
ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. Life Sci Alliance. 2022 05; 5(5).
ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.
Li Q, Lin J, Widrick JJ, Luo S, Li G, Zhang Y, Laporte J, Perrella MA, Liu X, Agrawal PB
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model. JCI Insight. 2022 08 08; 7(15).
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
Imani J, Bodine SPM, Lamattina AM, Ma DD, Shrestha S, Maynard DM, Bishop K, Nwokeji A, Malicdan MCV, Testa LC, Sood R, Stump B, Rosas IO, Perrella MA, Handin R, Young LR, Gochuico BR, El-Chemaly S
Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility. Respir Res. 2022 Jun 23; 23(1):167.
Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility.
Solomon JJ, Danoff SK, Woodhead FA, Hurwitz S, Maurer R, Glaspole I, Dellaripa PF, Gooptu B, Vassallo R, Cox PG, Flaherty KR, Adamali HI, Gibbons MA, Troy L, Forrest IA, Lasky JA, Spencer LG, Golden J, Scholand MB, Chaudhuri N, Perrella MA, Lynch DA, Chambers DC, Kolb M, Spino C, Raghu G, Goldberg HJ, Rosas IO
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. Lancet Respir Med. 2023 01; 11(1):87-96.
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study.
Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S
Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. J Biol Chem. 2022 11; 298(11):102580.
Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death.
Li Q, Lin J, Luo S, Schmitz-Abe K, Agrawal R, Meng M, Moghadaszadeh B, Beggs AH, Liu X, Perrella MA, Agrawal PB
bioRxiv : the preprint server for biology
Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex. bioRxiv. 2023 Apr 24.
Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex.
Mayers JR, Varon J, Zhou RR, Daniel-Ivad M, Beaulieu C, Bholse A, Glasser NR, Lichtenauer FM, Ng J, Vera MP, Huttenhower C, Perrella MA, Clish CB, Zhao SD, Baron RM, Balskus EP
Identification and targeting of microbial putrescine acetylation in bloodstream infections. bioRxiv. 2023 Sep 21.
Identification and targeting of microbial putrescine acetylation in bloodstream infections.
Ng J, Marneth AE, Griffith A, Younger D, Ghanta S, Jiao A, Willis G, Han J, Imani J, Niu B, Keegan JW, Hancock B, Guo F, Shi Y, Perrella MA, Lederer JA
Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells. J Innate Immun. 2023; 15(1):765-781.
Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells.
Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, Zhao R, Lam HC, Oldham WM, Ei-Chemaly S, Agrawal PB, Tian J, Liu X, Perrella MA
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes. Basic Res Cardiol. 2024 02; 119(1):151-168.
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
Spyropoulos F, Das AA, Waldeck-Weiermair M, Yadav S, Pandey AK, Guo R, Covington TA, Thulabandu V, Kosmas K, Steinhorn B, Perrella MA, Liu X, Christou H, Michel T
Adult and neonatal models of chemogenetic heart failure caused by oxidative stress. J Clin Invest. 2024 Mar 14; 134(9).
Adult and neonatal models of chemogenetic heart failure caused by oxidative stress.
Liu T, Liu S, Rui X, Cao Y, Hecker J, Guo F, Zhang Y, Gong L, Zhou Y, Yu Y, Krishnamoorthyni N, Bates S, Chun S, Boyer N, Xu S, Park JA, Perrella MA, Levy BD, Weiss ST, Mou H, Raby BA, Zhou X
Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation. Eur Respir J. 2024 May; 63(5).
Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.
Journal of cachexia, sarcopenia and muscle
Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex. J Cachexia Sarcopenia Muscle. 2024 Jun; 15(3):1003-1015.
Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex.
Hwang N, Ghanta S, Li Q, Lamattina AM, Murzin E, Lederer JA, El-Chemaly S, Chung SW, Liu X, Perrella MA
Molecular therapy : the journal of the American Society of Gene Therapy
Carbon monoxide-induced autophagy enhances human mesenchymal stromal cell function via paracrine actions in murine polymicrobial sepsis. Mol Ther. 2024 Jul 03; 32(7):2232-2247.
Carbon monoxide-induced autophagy enhances human mesenchymal stromal cell function via paracrine actions in murine polymicrobial sepsis.
Mayers JR, Varon J, Zhou RR, Daniel-Ivad M, Beaulieu C, Bhosle A, Glasser NR, Lichtenauer FM, Ng J, Vera MP, Huttenhower C, Perrella MA, Clish CB, Zhao SD, Baron RM, Balskus EP
A metabolomics pipeline highlights microbial metabolism in bloodstream infections. Cell. 2024 Jul 25; 187(15):4095-4112.e21.
A metabolomics pipeline highlights microbial metabolism in bloodstream infections.
Kosmas K, Papathanasiou AE, Spyropoulos F, Rehman R, Cunha AA, Fredenburgh LE, Perrella MA, Christou H
Stress Granule Assembly in Pulmonary Arterial Hypertension. Cells. 2024 10 30; 13(21).
Stress Granule Assembly in Pulmonary Arterial Hypertension.
Sanada F, Kim J, Czarna A, Chan NY, Signore S, Ogórek B, Isobe K, Wybieralska E, Borghetti G, Pesapane A, Sorrentino A, Mangano E, Cappetta D, Mangiaracina C, Ricciardi M, Cimini M, Ifedigbo E, Perrella MA, Goichberg P, Choi AM, Kajstura J, Hosoda T, Rota M, Anversa P, Leri A
c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res. 2014 Jan 03; 114(1):41-55.
c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.
Rehman R, Dieffenbach P, Vellarikkal SK, Corcoran AM, Pomales L, Arciniegas Rubio A, Zambrano Vera KV, Spyropoulos F, Kosmas K, Lam H, Filippakis H, Perrella MA, Fredenburgh LE, Christou H
PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2025 Dec; 73(6):859-870.
PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension.
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Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxid Redox Signal. 2014 Jan 20; 20(3):432-42.
Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.
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Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice. Stem Cell Res Ther. 2025 Jul 21; 16(1):394.
Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice.
Cellular Therapy for Sepsis and Lung Injury
Misra A, Weitman EM, Weitman M, Brook JR, Rone JM, Petrova B, Mertens RT, Hwang N, Vera KZ, Perrella MA, Baron RM, Kanarek N, Nowarski R
Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis. bioRxiv. 2025 May 22.
Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis.
Agrawal PB, Pierson CR, Joshi M, Liu X, Ravenscroft G, Moghadaszadeh B, Talabere T, Viola M, Swanson LC, Haliloglu G, Talim B, Yau KS, Allcock RJ, Laing NG, Perrella MA, Beggs AH
SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy. Am J Hum Genet. 2014 Aug 07; 95(2):218-26.
SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):445-55.
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.
Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA
Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol. 2015 Jan; 97(1):171-80.
Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713.
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015; 7(1):12.
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.
Cui Y, Liu K, Monzon-Medina ME, Padera RF, Wang H, George G, Toprak D, Abdelnour E, D'Agostino E, Goldberg HJ, Perrella MA, Forteza RM, Rosas IO, Visner G, El-Chemaly S
Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68.
Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection.
Liu X, Hall SRR, Wang Z, Huang H, Ghanta S, Di Sante M, Leri A, Anversa P, Perrella MA
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero. Nat Commun. 2015 Nov 23; 6:8825.
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.
Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97.
A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin.
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X
Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4681-7.
Hhip haploinsufficiency sensitizes mice to age-related emphysema.
CYTOKINE REGULATION OF VASCULAR SMOOTH MUSCLE CELL NOS
DNA Minor Groove-binding Drugs and Food-borne Pathogens
Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
Role of APEG-1 in Vascular Smooth Muscle Biology
Cardiomyocyte Differentiation Regulates Cardiac Function
Carbon Monoxide: Novel Opportunities for Therapy
Regulation of Neutrophil Function by Mesenchymal Stromal Cells During Sepsis
Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. Am J Respir Cell Mol Biol. 2017 03; 56(3):300-309.
Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA
Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245.
Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.
Perrella O, Perrella M, Cusumano V, Ibello U, Sbreglia C, De Sena R, Perrella A
International journal of immunopathology and pharmacology
Interleukin 10 and transforming growth factor beta 1 in hepatic fibrosis. Int J Immunopathol Pharmacol. 2002 Sep-Dec; 15(3):243-244.
Interleukin 10 and transforming growth factor beta 1 in hepatic fibrosis.
Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee ME, Haber E
Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J Clin Invest. 1996 Jul 15; 98(2):490-6.
Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.
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Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock. J Biol Chem. 1997 Feb 14; 272(7):4295-301.
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock.
Yoshizumi M, Wang H, Hsieh CM, Sibinga NE, Perrella MA, Lee ME
Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J Biol Chem. 1997 Aug 29; 272(35):22259-64.
Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein.
Wiesel P, Patel AP, DiFonzo N, Marria PB, Sim CU, Pellacani A, Maemura K, LeBlanc BW, Marino K, Doerschuk CM, Yet SF, Lee ME, Perrella MA
Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice. Circulation. 2000 Dec 12; 102(24):3015-22.
Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice.
Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen YH, Vom Saal J, Levy BD, Yet SF, Perrella MA
Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J. 2003 Jul; 17(10):1325-7.
Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death.
Canadian journal of physiology and pharmacology
Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications. Can J Physiol Pharmacol. 1991 Oct; 69(10):1576-81.
Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications.
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Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53.
Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.
Lung biopsy. Adv Intern Med. 1992; 37:337-61.
Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA, Lee ME
Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J Biol Chem. 2000 Aug 18; 275(33):25766-73.
Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages.
Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP
Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 07; 57(1):47-58.
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Pathobiology of sepsis: are we still asking the same questions?
Sibinga NE, Foster LC, Hsieh CM, Perrella MA, Lee WS, Endege WO, Sage EH, Lee ME, Haber E
Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. Circ Res. 1997 Apr; 80(4):532-41.
Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury.
Chin MT, Pellacani A, Wang H, Lin SS, Jain MK, Perrella MA, Lee ME
Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). J Biol Chem. 1998 Apr 17; 273(16):9755-60.
Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).
Chin MT, Pellacani A, Hsieh CM, Lin SS, Jain MK, Patel A, Huggins GS, Reeves R, Perrella MA, Lee ME
Journal of molecular and cellular cardiology
Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro. J Mol Cell Cardiol. 1999 Dec; 31(12):2199-205.
Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro.
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Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8.
Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.
Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803.
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia.
Perrella MA, Edell ES, Krowka MJ, Cortese DA, Burnett JC
Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia. Am J Physiol. 1992 Jul; 263(1 Pt 2):R45-50.
Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia.
Ith B, Wei J, Yet SF, Perrella MA, Layne MD
Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development. Gene Expr Patterns. 2005 Apr; 5(4):533-7.
Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development.
Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME
Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem. 1999 Oct 29; 274(44):31565-70.
Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001 Jul 20; 89(2):168-73.
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.
Ghatak S, Markwald RR, Hascall VC, Dowling W, Lottes RG, Baatz JE, Beeson G, Beeson CC, Perrella MA, Thannickal VJ, Misra S
Transforming growth factor ß1 (TGFß1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem. 2017 06 23; 292(25):10465-10489.
Transforming growth factor ß1 (TGFß1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.
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Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice.
Pellacani A, Chin MT, Wiesel P, Ibanez M, Patel A, Yet SF, Hsieh CM, Paulauskis JD, Reeves R, Lee ME, Perrella MA
Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase. J Biol Chem. 1999 Jan 15; 274(3):1525-32.
Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.
Hsieh CM, Fukumoto S, Layne MD, Maemura K, Charles H, Patel A, Perrella MA, Lee ME
Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1. J Biol Chem. 2000 Nov 24; 275(47):36966-73.
Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1.
High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Suppl):S36-42.
High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses.
Perrella MA, Hildebrand FL, Margulies KB, Burnett JC
Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function. Am J Physiol. 1991 Aug; 261(2 Pt 2):R323-8.
Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function.
Bishop A, Yet SF, Lee ME, Perrella MA, Demple B
Biochemical and biophysical research communications
A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. Biochem Biophys Res Commun. 2004 Dec 03; 325(1):3-9.
A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia.
Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9.
Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.
Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC
Endothelin: a new cardiovascular regulatory peptide. Mayo Clin Proc. 1990 Nov; 65(11):1441-55.
Endothelin: a new cardiovascular regulatory peptide.
Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME
Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001 Aug; 21(15):5256-61.
Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein.
Storm van's Gravesande K, Layne MD, Ye Q, Le L, Baron RM, Perrella MA, Santambrogio L, Silverman ES, Riese RJ
IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. J Immunol. 2002 May 01; 168(9):4488-94.
IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression.
Experimental biology and medicine (Maywood, N.J.)
Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function. Exp Biol Med (Maywood). 2003 May; 228(5):447-53.
Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function.
Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin. J Biol Chem. 2005 Feb 11; 280(6):4578-84.
Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin.
Sibinga NE, Wang H, Perrella MA, Endege WO, Patterson C, Yoshizumi M, Haber E, Lee ME
Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter. J Biol Chem. 1999 Apr 23; 274(17):12139-46.
Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter.
DiChiara MR, Kiely JM, Gimbrone MA, Lee ME, Perrella MA, Topper JN
Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. J Exp Med. 2000 Sep 04; 192(5):695-704.
Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals.
Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME
Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem. 2001 May 18; 276(20):17479-83.
Akt participation in the Wnt signaling pathway through Dishevelled.
Ejima K, Layne MD, Carvajal IM, Nanri H, Ith B, Yet SF, Perrella MA
Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression. Antioxid Redox Signal. 2002 Aug; 4(4):569-75.
Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression.
Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA
Elk-3 is a transcriptional repressor of nitric-oxide synthase 2. J Biol Chem. 2003 Oct 10; 278(41):39572-7.
Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.
Role of heme oxygenase-1 in cardiovascular function. Curr Pharm Des. 2003; 9(30):2479-87.
Role of heme oxygenase-1 in cardiovascular function.
Margulies KB, Heublein DM, Perrella MA, Burnett JC
ANF-mediated renal cGMP generation in congestive heart failure. Am J Physiol. 1991 Apr; 260(4 Pt 2):F562-8.
ANF-mediated renal cGMP generation in congestive heart failure.
Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA
Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8.
Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.
Yet SF, McA'Nulty MM, Folta SC, Yen HW, Yoshizumi M, Hsieh CM, Layne MD, Chin MT, Wang H, Perrella MA, Jain MK, Lee ME
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem. 1998 Jan 09; 273(2):1026-31.
Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.
Agrawal RS, Muangman S, Layne MD, Melo L, Perrella MA, Lee RT, Zhang L, Lopez-Ilasaca M, Dzau VJ
Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. Gene Ther. 2004 Jun; 11(12):962-9.
Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival.
Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22.
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.
Wiesel P, Foster LC, Pellacani A, Layne MD, Hsieh CM, Huggins GS, Strauss P, Yet SF, Perrella MA
Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators. J Biol Chem. 2000 Aug 11; 275(32):24840-6.
Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators.
Pellacani A, Wiesel P, Razavi S, Vasilj V, Feinberg MW, Chin MT, Reeves R, Perrella MA
Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1. J Biol Chem. 2001 Jan 12; 276(2):1653-9.
Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1.
Yet SF, Layne MD, Liu X, Chen YH, Ith B, Sibinga NE, Perrella MA
Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 2003 Sep; 17(12):1759-61.
Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling.
Chen X, Wang S, Xu H, Pereira JD, Hatzistergos KE, Saur D, Seidler B, Hare JM, Perrella MA, Yin ZQ, Liu X
Evidence for a retinal progenitor cell in the postnatal and adult mouse. Stem Cell Res. 2017 08; 23:20-32.
Evidence for a retinal progenitor cell in the postnatal and adult mouse.
Fredenburgh LE, Perrella MA, Mitsialis SA
The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65.
The role of heme oxygenase-1 in pulmonary disease.
Role of haem oxygenase-1 in microbial host defence. Cell Microbiol. 2009 Feb; 11(2):199-207.
Role of haem oxygenase-1 in microbial host defence.
Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA
High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35.
High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.
Yoshizumi M, Lee WS, Hsieh CM, Tsai JC, Li J, Perrella MA, Patterson C, Endege WO, Schlegel R, Lee ME
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Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.
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Arteriosclerosis, thrombosis, and vascular biology
Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2441-7.
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Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9.
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Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.
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Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation. 2004 Apr 13; 109(14):1769-75.
Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.
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Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics. 2013 May; 101(5):263-72.
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.
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Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure. Am J Physiol. 1993 Jul; 265(1 Pt 2):H401-8.
Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure.
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ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem. 2001 Feb 02; 276(5):3302-9.
ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.
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Annals of the New York Academy of Sciences
Molecular mechanisms of morning onset of myocardial infarction. Ann N Y Acad Sci. 2001 Dec; 947:398-402.
Molecular mechanisms of morning onset of myocardial infarction.
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Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26.
Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
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Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem. 1995 Sep 29; 270(39):23111-8.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
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Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.
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Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Crit Care Med. 2007 Mar; 35(3):849-55.
Plasma gelsolin is a marker and therapeutic agent in animal sepsis.
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Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest. 2008 Jan; 118(1):239-47.
Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.
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The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol Cell Biol. 1995 Jun; 15(6):3266-72.
The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells.
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APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996 Jul 19; 271(29):17354-9.
APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.
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Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806.
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Mesenchymal Stromal Cell Therapy: Does the Source Matter? Crit Care Med. 2018 02; 46(2):343-345.
Mesenchymal Stromal Cell Therapy: Does the Source Matter?
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Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition. Am J Physiol. 1993 Mar; 264(3 Pt 2):F411-4.
Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition.
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Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. J Biol Chem. 1998 Jun 19; 273(25):15654-60.
Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.
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Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells. J Biol Chem. 1998 Aug 07; 273(32):20341-6.
Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells.
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Cardiac atrial natriuretic factor during evolution of congestive heart failure. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1248-55.
Cardiac atrial natriuretic factor during evolution of congestive heart failure.
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Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure. J Clin Invest. 1991 Nov; 88(5):1636-42.
Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure.
Heme oxygenase 1 in regulation of inflammation and oxidative damage. Methods Enzymol. 2002; 353:163-76.
Heme oxygenase 1 in regulation of inflammation and oxidative damage.
Role of HO-1 in renoprotection: location, location, location. Kidney Int. 2004 May; 65(5):1968-9.
Role of HO-1 in renoprotection: location, location, location.
Yet SF, Folta SC, Jain MK, Hsieh CM, Maemura K, Layne MD, Zhang D, Marria PB, Yoshizumi M, Chin MT, Perrella MA, Lee ME
Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice. J Biol Chem. 1998 Apr 24; 273(17):10530-7.
Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice.
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Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif. J Biol Chem. 1999 May 14; 274(20):14344-51.
Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif.
Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, Yet SF, Layne MD, Perrella MA, Dzau VJ
Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation. 2002 Feb 05; 105(5):602-7.
Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene.
Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E, Lee ME
Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem. 1997 Oct 03; 272(40):25380-5.
Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine.
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Journal of the American Society of Nephrology : JASN
Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor. J Am Soc Nephrol. 1992 Aug; 3(2):196-202.
Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor.