Perrella, Mark
eCommons Login: MAP11
first name: Mark
last name: Perrella
coauthor of: Liu, Xiaoli
coauthor of: Ghanta, Sailaja
coauthor of: Baron, Rebecca
coauthor of: Lederer, James
coauthor of: Christou, Helen
full name: Mark A. Perrella, M.D.
has faculty rank: Associate Professor
has network: selected publications
has network: research areas
has network: coauthor of
has network: similar to
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 3628
person in primary position: Associate Professor of Medicine
physical neighbor: Fanta, Christopher
physical neighbor: Goldberg, Hilary
physical neighbor: Hunninghake, Gary
physical neighbor: Israel, Elliot
physical neighbor: Massaro, Anthony
similar to: Otterbein, Leo
similar to: Fauza, Dario
similar to: Rhee, Chanu
similar to: Libby, Peter
similar to: Serhan, Charles
type: Agent
type: Person
selected publications: Authorship 1782964
selected publications: Authorship 1780230
selected publications: Authorship 1844277
selected publications: Authorship 1705806
selected publications: Authorship 1662977
selected publications: Authorship 1651852
selected publications: Authorship 1647577
selected publications: Authorship 1636032
selected publications: Authorship 1650889
selected publications: Authorship 1616802
selected publications: Authorship 1594200
selected publications: Authorship 1595126
selected publications: Authorship 1561186
selected publications: Authorship 1502408
selected publications: Authorship 1488680
selected publications: Authorship 1468203
selected publications: Authorship 1466974
selected publications: Authorship 1422003
selected publications: Authorship 1434332
selected publications: Authorship 1441278
selected publications: Authorship 1405183
selected publications: Authorship 1406186
selected publications: Authorship 1389670
selected publications: Authorship 1381672
selected publications: Authorship 1344961
selected publications: Authorship 1321883
selected publications: Authorship 1358990
selected publications: Authorship 1297600
selected publications: Authorship 1270787
selected publications: Authorship 1234289
selected publications: Authorship 1233354
selected publications: Authorship 1227924
selected publications: Authorship 1202876
selected publications: Authorship 1120725
selected publications: Authorship 1140773
selected publications: Authorship 1118186
selected publications: Authorship 1084302
selected publications: Authorship 1077790
selected publications: Authorship 1046533
selected publications: Authorship 1038446
selected publications: Authorship 1041956
selected publications: Authorship 1053335
selected publications: Authorship 966607
selected publications: Authorship 994346
selected publications: Authorship 976130
selected publications: Authorship 922698
selected publications: Authorship 921364
selected publications: Authorship 897014
selected publications: Authorship 892866

eCommons Login
tag name: catalyst:eCommonsLogin
type: DatatypeProperty

coauthor of
tag name: prns:coAuthorOf
type: ObjectProperty

end date
tag name: prns:endDate
type: DatatypeProperty

Faculty Rank
type: Class

full name
tag name: prns:fullName
type: DatatypeProperty

author list
tag name: prns:hasAuthorList
type: DatatypeProperty

has faculty rank
tag name: prns:hasFacultyRank
type: ObjectProperty

has network
tag name: prns:hasNetwork
type: ObjectProperty

published in
tag name: prns:hasPublicationVenue
type: DatatypeProperty

information resource reference
tag name: prns:informationResourceReference
type: DatatypeProperty

is primary position
tag name: prns:isPrimaryPosition
type: DatatypeProperty

latitude
tag name: prns:latitude
type: DatatypeProperty

longitude
tag name: prns:longitude
type: DatatypeProperty

photo
tag name: prns:mainImage
type: ObjectProperty

maximum weight
tag name: prns:maxWeight
type: DatatypeProperty

journal title abbreviation
tag name: prns:medlineTA
type: DatatypeProperty

MeSH DescriptorUI
tag name: prns:meshDescriptorUI
type: DatatypeProperty

MeSH semantic group name
tag name: prns:meshSemanticGroupName
type: DatatypeProperty

minimum weight
tag name: prns:minWeight
type: DatatypeProperty

number of authors
tag name: prns:numberOfAuthors
type: DatatypeProperty

number of connections
tag name: prns:numberOfConnections
type: DatatypeProperty

number of publications
tag name: prns:numberOfPublications
type: DatatypeProperty

Person ID
tag name: prns:personId
type: DatatypeProperty

person in primary position
tag name: prns:personInPrimaryPosition
type: ObjectProperty

physical neighbor
tag name: prns:physicalNeighborOf
type: ObjectProperty

position in department
tag name: prns:positionInDepartment
type: ObjectProperty

position in division
tag name: prns:positionInDivision
type: ObjectProperty

predicate node
tag name: prns:predicateNode
type: ObjectProperty

principal investigator name
tag name: prns:principalInvestigatorName
type: DatatypeProperty

publication date
tag name: prns:publicationDate
type: DatatypeProperty

similar to
tag name: prns:similarTo
type: ObjectProperty

sort order
tag name: prns:sortOrder
type: DatatypeProperty

start date
tag name: prns:startDate
type: DatatypeProperty

uniqueness weight
tag name: prns:uniquenessWeight
type: DatatypeProperty

year
tag name: prns:year
type: DatatypeProperty

Academic Article
type: Class

Article
type: Class

Document
type: Class

PubMed Identifier
tag name: bibo:pmid
type: DatatypeProperty

Address
type: Class

address line 1
tag name: vivo:address1
type: DatatypeProperty

address line 2
tag name: vivo:address2
type: DatatypeProperty

address line 3
tag name: vivo:address3
type: DatatypeProperty

city
tag name: vivo:addressCity
type: DatatypeProperty
type: FunctionalProperty

postal code
tag name: vivo:addressPostalCode
type: DatatypeProperty
type: FunctionalProperty

state or province
tag name: vivo:addressState
type: DatatypeProperty
type: FunctionalProperty

selected publications
tag name: vivo:authorInAuthorship
type: ObjectProperty

author rank in publication
tag name: vivo:authorRank
type: DatatypeProperty
type: FunctionalProperty

Authorship
type: Class

Department
type: Class

Division
type: Class

Grant
type: Class

research areas
tag name: vivo:hasResearchArea
type: ObjectProperty

research activities
tag name: vivo:hasResearcherRole
type: ObjectProperty

HR job title
tag name: vivo:hrJobTitle
type: DatatypeProperty

Information Resource
type: Class

linked author
tag name: vivo:linkedAuthor
type: ObjectProperty

linked information resource
tag name: vivo:linkedInformationResource
type: ObjectProperty

mailing address
tag name: vivo:mailingAddress
type: ObjectProperty

middle name or initial
tag name: vivo:middleName
type: DatatypeProperty
type: FunctionalProperty

overview
tag name: vivo:overview
type: DatatypeProperty
type: FunctionalProperty

positions
tag name: vivo:personInPosition
type: ObjectProperty

phone
tag name: vivo:phoneNumber
type: DatatypeProperty

Position
type: Class

position in organization
tag name: vivo:positionInOrganization
type: ObjectProperty

preferred title
tag name: vivo:preferredTitle
type: DatatypeProperty
type: FunctionalProperty

Researcher Role
type: Class

researcher role of
tag name: vivo:researcherRoleOf
type: ObjectProperty

contributes to
tag name: vivo:roleContributesTo
type: ObjectProperty

sponsor award id
tag name: vivo:sponsorAwardId
type: DatatypeProperty
type: FunctionalProperty

predicate
tag name: rdf:predicate
type: ObjectProperty

type
tag name: rdf:type
type: ObjectProperty

label
tag name: rdfs:label
type: DatatypeProperty

Concept
type: Class

Agent
type: Class

first name
tag name: foaf:firstName
type: DatatypeProperty
type: FunctionalProperty

last name
tag name: foaf:lastName
type: DatatypeProperty
type: FunctionalProperty

Organization
type: Class

Person
type: Class

Authorship 1046533
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling.

SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling.
PubMed Identifier: 29474540
author list: Huntoon V, Widrick JJ, Sanchez C, Rosen SM, Kutchukian C, Cao S, Pierson CR, Liu X, Perrella MA, Beggs AH, Jacquemond V, Agrawal PB
published in: Human molecular genetics
information resource reference: SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling. Hum Mol Genet. 2018 05 01; 27(9):1608-1617.
journal title abbreviation: Hum Mol Genet
publication date: 2018-05-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice.
PubMed Identifier: 11375280
author list: Wiesel P, Patel AP, Carvajal IM, Wang ZY, Pellacani A, Maemura K, DiFonzo N, Rennke HG, Layne MD, Yet SF, Lee ME, Perrella MA
published in: Circulation research
information resource reference: Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res. 2001 May 25; 88(10):1088-94.
journal title abbreviation: Circ Res
publication date: 2001-05-25T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 101884
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.
PubMed Identifier: 7685252
author list: Yoshizumi M, Perrella MA, Burnett JC, Lee ME
published in: Circulation research
information resource reference: Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res. 1993 Jul; 73(1):205-9.
journal title abbreviation: Circ Res
publication date: 1993-07-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1053335
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation.

NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation.
PubMed Identifier: 29560100
author list: Kwon MY, Hwang N, Park YJ, Perrella MA, Chung SW
published in: Oncotarget
information resource reference: NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation. Oncotarget. 2018 Feb 27; 9(16):12671-12681.
journal title abbreviation: Oncotarget
publication date: 2018-01-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1.
PubMed Identifier: 9721696
author list: Pellacani A, Wiesel P, Sharma A, Foster LC, Huggins GS, Yet SF, Perrella MA
published in: Circulation research
information resource reference: Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1. Circ Res. 1998 Aug 24; 83(4):396-403.
journal title abbreviation: Circ Res
publication date: 1998-08-24T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells.
PubMed Identifier: 1447224
author list: Temizer DH, Yoshizumi M, Perrella MA, Susanni EE, Quertermous T, Lee ME
published in: The Journal of biological chemistry
information resource reference: Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells. J Biol Chem. 1992 Dec 05; 267(34):24892-6.
journal title abbreviation: J Biol Chem
publication date: 1992-12-05T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonists
end date: 2024-03-31
principal investigator name: LEDERER, JAMES A. ;PERRELLA, MARK A
start date: 2018-04-01
type: Grant
sponsor award id: U01AI138318

Co-Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Therapy of acute radiation syndrome and its complications by mesenchymal stromal cells conditioned with Toll-like receptor 9 agonists

Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators.
PubMed Identifier: 7996789
author list: Tan MS, Tsai JC, Lee YJ, Chen HC, Shin SJ, Lai YH, Perrella MA, Bianchi C, Higashiyama S, Endege W
published in: Kidney international
information resource reference: Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators. Kidney Int. 1994 Sep; 46(3):690-5.
journal title abbreviation: Kidney Int
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Natriuretic peptide system in human heart failure.
PubMed Identifier: 8353861
author list: Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC
published in: Circulation
information resource reference: Natriuretic peptide system in human heart failure. Circulation. 1993 Sep; 88(3):1004-9.
journal title abbreviation: Circulation
publication date: 1993-09-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.
PubMed Identifier: 8550827
author list: Tsai JC, Wang H, Perrella MA, Yoshizumi M, Sibinga NE, Tan LC, Haber E, Chang TH, Schlegel R, Lee ME
published in: The Journal of clinical investigation
information resource reference: Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest. 1996 Jan 01; 97(1):146-53.
journal title abbreviation: J Clin Invest
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells.
PubMed Identifier: 11606591
author list: Chen YH, Layne MD, Watanabe M, Yet SF, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells. J Biol Chem. 2001 Dec 14; 276(50):47658-63.
journal title abbreviation: J Biol Chem
publication date: 2001-10-17T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 110148
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/748450

Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells.
PubMed Identifier: 11934842
author list: Layne MD, Yet SF, Maemura K, Hsieh CM, Liu X, Ith B, Lee ME, Perrella MA
published in: Circulation research
information resource reference: Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells. Circ Res. 2002 Apr 05; 90(6):728-36.
journal title abbreviation: Circ Res
publication date: 2002-04-05T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case.
PubMed Identifier: 1742039
author list: Perrella MA, Smith HC, Khandheria BK
published in: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
information resource reference: Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case. J Am Soc Echocardiogr. 1991 Sep-Oct; 4(5):499-502.
journal title abbreviation: J Am Soc Echocardiogr
publication date: 1991-09-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 102976
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/882070

Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.
PubMed Identifier: 18937643
author list: Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC
published in: The Biochemical journal
information resource reference: Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15; 418(1):103-12.
journal title abbreviation: Biochem J
publication date: 2009-02-15T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.
PubMed Identifier: 19179605
author list: Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD
published in: The American journal of pathology
information resource reference: Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Am J Pathol. 2009 Mar; 174(3):818-28.
journal title abbreviation: Am J Pathol
publication date: 2009-01-29T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility.
PubMed Identifier: 19577709
author list: Fredenburgh LE, Ma J, Perrella MA
published in: Trends in cardiovascular medicine
information resource reference: Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009 Feb; 19(2):31-7.
journal title abbreviation: Trends Cardiovasc Med
publication date: 2009-02-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
PubMed Identifier: 7878003
author list: Morita T, Perrella MA, Lee ME, Kourembanas S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1475-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1995-02-28T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.
PubMed Identifier: 7929446
author list: Perrella MA, Mäki T, Prasad S, Pimental D, Singh K, Takahashi N, Yoshizumi M, Alali A, Higashiyama S, Kelly RA
published in: The Journal of biological chemistry
information resource reference: Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes. J Biol Chem. 1994 Oct 28; 269(43):27045-50.
journal title abbreviation: J Biol Chem
publication date: 1994-10-28T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Arrest of endotoxin-induced hypotension by transforming growth factor beta1.
PubMed Identifier: 8700884
author list: Perrella MA, Hsieh CM, Lee WS, Shieh S, Tsai JC, Patterson C, Lowenstein CJ, Long NC, Haber E, Shore S, Lee ME
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Arrest of endotoxin-induced hypotension by transforming growth factor beta1. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2054-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-03-05T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages.
PubMed Identifier: 16456000
author list: Chung SW, Chen YH, Yet SF, Layne MD, Perrella MA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages. J Immunol. 2006 Feb 15; 176(4):2414-20.
journal title abbreviation: J Immunol
publication date: 2006-02-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels.
PubMed Identifier: 16309574
author list: Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA
published in: Cellular and molecular biology (Noisy-le-Grand, France)
information resource reference: Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 03; 51(5):513-20.
journal title abbreviation: Cell Mol Biol (Noisy-le-grand)
publication date: 2005-10-03T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 106662
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications.

Authorship 1077790
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis.

Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis.
PubMed Identifier: 29975792
author list: Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA
published in: Journal of leukocyte biology
information resource reference: Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol. 2018 10; 104(4):677-689.
journal title abbreviation: J Leukoc Biol
publication date: 2018-07-05T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.
PubMed Identifier: 16449792
author list: Liu X, Pachori AS, Ward CA, Davis JP, Gnecchi M, Kong D, Zhang L, Murduck J, Yet SF, Perrella MA, Pratt RE, Dzau VJ, Melo LG
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. FASEB J. 2006 Feb; 20(2):207-16.
journal title abbreviation: FASEB J
publication date: 2006-02-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.
PubMed Identifier: 18279675
author list: Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA
published in: FEBS letters
information resource reference: High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008 Mar 05; 582(5):810-4.
journal title abbreviation: FEBS Lett
publication date: 2008-02-13T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1084302
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure.

Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure.
PubMed Identifier: 30042693
author list: Shu C, Huang H, Xu Y, Rota M, Sorrentino A, Peng Y, Padera RF, Huntoon V, Agrawal PB, Liu X, Perrella MA
published in: Frontiers in physiology
information resource reference: Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure. Front Physiol. 2018; 9:863.
journal title abbreviation: Front Physiol
publication date: 2018-07-10T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 114790
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.
PubMed Identifier: 8022789
author list: Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, Lee ME
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6369-73.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-07-05T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 101593
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1.

Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression.
PubMed Identifier: 20348279
author list: Hung CC, Liu X, Kwon MY, Kang YH, Chung SW, Perrella MA
published in: American journal of physiology. Lung cellular and molecular physiology
information resource reference: Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L870-9.
journal title abbreviation: Am J Physiol Lung Cell Mol Physiol
publication date: 2010-03-26T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
PubMed Identifier: 18854316
author list: Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL
published in: The Journal of biological chemistry
information resource reference: Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36.
journal title abbreviation: J Biol Chem
publication date: 2008-10-14T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme oxygenase-1: a multifaceted triple-threat molecule.
PubMed Identifier: 17227881
author list: Perrella MA
published in: American journal of respiratory cell and molecular biology
information resource reference: Heme oxygenase-1: a multifaceted triple-threat molecule. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):137.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2007-02-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells.
PubMed Identifier: 9468491
author list: Arkonac BM, Foster LC, Sibinga NE, Patterson C, Lai K, Tsai JC, Lee ME, Perrella MA, Haber E
published in: The Journal of biological chemistry
information resource reference: Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells. J Biol Chem. 1998 Feb 20; 273(8):4400-5.
journal title abbreviation: J Biol Chem
publication date: 1998-02-20T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells.
PubMed Identifier: 8626582
author list: Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA, Haber E, Lee ME
published in: The Journal of biological chemistry
information resource reference: Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. J Biol Chem. 1996 Apr 26; 271(17):10194-9.
journal title abbreviation: J Biol Chem
publication date: 1996-04-26T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils.
PubMed Identifier: 23132816
author list: Hall SR, Tsoyi K, Ith B, Padera RF, Lederer JA, Wang Z, Liu X, Perrella MA
published in: Stem cells (Dayton, Ohio)
information resource reference: Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells. 2013 Feb; 31(2):397-407.
journal title abbreviation: Stem Cells
publication date: 2013-02-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.
PubMed Identifier: 11018023
author list: Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem. 2000 Nov 24; 275(47):36847-51.
journal title abbreviation: J Biol Chem
publication date: 2000-11-24T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.
PubMed Identifier: 7514175
author list: Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, Lee ME
published in: The Journal of biological chemistry
information resource reference: Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem. 1994 May 20; 269(20):14595-600.
journal title abbreviation: J Biol Chem
publication date: 1994-05-20T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1118186
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.
PubMed Identifier: 30518685
author list: Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM
published in: JCI insight
information resource reference: A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 12 06; 3(23).
journal title abbreviation: JCI Insight
publication date: 2018-12-06T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 112992
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells.

Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.
PubMed Identifier: 30562054
author list: Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO
published in: American journal of respiratory cell and molecular biology
information resource reference: Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. Am J Respir Cell Mol Biol. 2019 06; 60(6):659-666.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2019-06-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1120725
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.

Increased production of nitric oxide in coronary arteries during congestive heart failure.
PubMed Identifier: 8282783
author list: O'Murchu B, Miller VM, Perrella MA, Burnett JC
published in: The Journal of clinical investigation
information resource reference: Increased production of nitric oxide in coronary arteries during congestive heart failure. J Clin Invest. 1994 Jan; 93(1):165-71.
journal title abbreviation: J Clin Invest
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice.
PubMed Identifier: 11481226
author list: Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Aug; 15(10):1774-6.
journal title abbreviation: FASEB J
publication date: 2001-08-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice.
PubMed Identifier: 11606480
author list: Layne MD, Patel A, Chen YH, Rebel VI, Carvajal IM, Pellacani A, Ith B, Zhao D, Schreiber BM, Yet SF, Lee ME, Storch J, Perrella MA
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Dec; 15(14):2733-5.
journal title abbreviation: FASEB J
publication date: 2001-10-15T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs.
PubMed Identifier: 1850758
author list: Perrella MA, Margulies KB, Wei CM, Aarhus LL, Heublein DM, Burnett JC
published in: The Journal of clinical investigation
information resource reference: Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs. J Clin Invest. 1991 May; 87(5):1649-55.
journal title abbreviation: J Clin Invest
publication date: 1991-05-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

PU.1 regulates cathepsin S expression in professional APCs.
PubMed Identifier: 16365419
author list: Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 01; 176(1):275-83.
journal title abbreviation: J Immunol
publication date: 2006-01-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased endothelin in experimental heart failure.
PubMed Identifier: 2242543
author list: Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC
published in: Circulation
information resource reference: Increased endothelin in experimental heart failure. Circulation. 1990 Dec; 82(6):2226-30.
journal title abbreviation: Circulation
publication date: 1990-12-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.
PubMed Identifier: 20498830
author list: Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA
published in: PloS one
information resource reference: Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One. 2010 May 14; 5(5):e10656.
journal title abbreviation: PLoS One
publication date: 2010-05-14T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.
PubMed Identifier: 22435680
author list: Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J
published in: European journal of clinical investigation
information resource reference: Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13.
journal title abbreviation: Eur J Clin Invest
publication date: 2012-03-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

HMGA1a Protein
MeSH DescriptorUI: D025741
MeSH semantic group name: Chemicals & Drugs
number of authors: 35
number of publications: 67
uniqueness weight: 0.953801
type: Concept

Mesenchymal Stem Cells
MeSH DescriptorUI: D044982
MeSH semantic group name: Anatomy
number of authors: 715
number of publications: 1759
uniqueness weight: 0.463832
type: Concept

Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways.
PubMed Identifier: 30964887
author list: Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S
published in: PloS one
information resource reference: Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831.
journal title abbreviation: PLoS One
publication date: 2019-04-09T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme Oxygenase (Decyclizing)
MeSH DescriptorUI: D006419
MeSH semantic group name: Chemicals & Drugs
number of authors: 61
number of publications: 171
uniqueness weight: 0.929036
type: Concept

Heme Oxygenase-1
MeSH DescriptorUI: D051547
MeSH semantic group name: Chemicals & Drugs
number of authors: 158
number of publications: 378
uniqueness weight: 0.810691
type: Concept

Authorship 1140773
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways.

Authorship 131956
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators.

Sepsis
MeSH DescriptorUI: D018805
MeSH semantic group name: Disorders
number of authors: 1112
number of publications: 2777
uniqueness weight: 0.357831
type: Concept

Anaesthesia
type: Department
type: Organization

Medicine
type: Department
type: Organization

Pediatrics
type: Department
type: Organization

Population Medicine
type: Department
type: Organization

Surgery
type: Department
type: Organization

Cardiology
type: Division
type: Organization

Pulmonary
type: Division
type: Organization

Beth Israel Deaconess Medical Center
type: Organization

Brigham and Women's Hospital
type: Organization

Boston Children's Hospital
type: Organization

Libby, Peter
eCommons Login: PL2
first name: Peter
last name: Libby
full name: Peter Libby, M.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 58636
person in primary position: Mallinckrodt Professor of Medicine
type: Agent
type: Person
preferred title: Mallinckrodt Professor of Medicine

Hunninghake, Gary
eCommons Login: GH23
first name: Gary
last name: Hunninghake
full name: Gary Hunninghake, M.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 41479
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Fanta, Christopher
eCommons Login: CHF2
first name: Christopher
last name: Fanta
full name: Christopher Hardy Fanta, M.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 25016
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Israel, Elliot
eCommons Login: EI1
first name: Elliot
last name: Israel
full name: Elliot Israel, M.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 11018
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Serhan, Charles
eCommons Login: CNS3
first name: Charles
last name: Serhan
full name: Charles Nicholas Serhan, Ph.D.
has faculty rank: Full Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 17417
person in primary position: Simon Gelman Professor of Anaesthesia
type: Agent
type: Person
preferred title: Simon Gelman Professor of Anaesthesia

Liu, Xiaoli
eCommons Login: XL19
first name: Xiaoli
last name: Liu
full name: Xiaoli Liu, M.D., Ph.D.
has faculty rank: Assistant Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 21819
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Otterbein, Leo
eCommons Login: LO6
first name: Leo
last name: Otterbein
full name: Leo E. Otterbein, Ph.D.
has faculty rank: Full Professor
latitude: 42.34620670000000
longitude: -71.09978340000000
Person ID: 64352
person in primary position: Professor of Surgery
type: Agent
type: Person
preferred title: Professor of Surgery

Lederer, James
eCommons Login: JAL16
first name: James
last name: Lederer
full name: James Arthur Lederer, Ph.D.
has faculty rank: Associate Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 81962
person in primary position: Associate Professor of Surgery
type: Agent
type: Person
preferred title: Associate Professor of Surgery

selected publications
maximum weight: 1
minimum weight: 1
number of connections: 183
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/113
predicate: selected publications
type: Network

research areas
maximum weight: 3.22548
minimum weight: 0.00198809
number of connections: 750
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/217
predicate: research areas
type: Network

coauthor of
maximum weight: 4.45186
minimum weight: 0.0104852
number of connections: 88
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/363
predicate: coauthor of
type: Network

similar to
maximum weight: 67.3828
minimum weight: 15.8395
number of connections: 60
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/494
predicate: similar to
type: Network

Baron, Rebecca
eCommons Login: RMB3
first name: Rebecca
last name: Baron
full name: Rebecca Marlene Baron, M.D.
has faculty rank: Associate Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 47642
person in primary position: Associate Professor of Medicine
type: Agent
type: Person
preferred title: Associate Professor of Medicine

Christou, Helen
eCommons Login: HAC1
first name: Helen
last name: Christou
full name: Helen A. Christou, M.D.
has faculty rank: Associate Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 22372
person in primary position: Mary Ellen Avery Associate Professor of Pediatrics in the Field of Newborn Medicine
type: Agent
type: Person
preferred title: Mary Ellen Avery Associate Professor of Pediatrics in the Field of Newborn Medicine

Massaro, Anthony
eCommons Login: AFM1
first name: Anthony
last name: Massaro
full name: Anthony Francis Massaro, M.D.
has faculty rank: Instructor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 50825
person in primary position: Instructor in Medicine
type: Agent
type: Person
preferred title: Instructor in Medicine

Ghanta, Sailaja
eCommons Login: SG265
first name: Sailaja
last name: Ghanta
full name: Sailaja Ghanta, M.D.
has faculty rank: Assistant Professor
Person ID: 102014
person in primary position: Assistant Professor of Pediatrics
type: Agent
type: Person
preferred title: Assistant Professor of Pediatrics

Goldberg, Hilary
eCommons Login: HJG4
first name: Hilary
last name: Goldberg
full name: Hilary Jennifer Goldberg, M.D.
has faculty rank: Associate Professor
latitude: 42.33510370000000
longitude: -71.10616490000000
Person ID: 72092
person in primary position: Associate Professor of Medicine
type: Agent
type: Person
preferred title: Associate Professor of Medicine

Fauza, Dario
eCommons Login: DDF1
first name: Dario
last name: Fauza
full name: Dario De Oliveira Fauza, M.D.
has faculty rank: Associate Professor
latitude: 42.33743600000000
longitude: -71.10544700000000
Person ID: 84473
person in primary position: Associate Professor of Surgery
type: Agent
type: Person
preferred title: Associate Professor of Surgery

Rhee, Chanu
eCommons Login: CR109
first name: Chanu
last name: Rhee
full name: Chanu Rhee, M.D.
has faculty rank: Associate Professor
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 110143
person in primary position: Associate Professor of Population Medicine
type: Agent
type: Person
preferred title: Associate Professor of Population Medicine

Authorship 1202876
type: Authorship
author rank in publication: 16
linked author: Perrella, Mark
linked information resource: Biobanking and cryopreservation of human lung explants for omic analysis.

Biobanking and cryopreservation of human lung explants for omic analysis.
PubMed Identifier: 31699836
author list: Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO
published in: The European respiratory journal
information resource reference: Biobanking and cryopreservation of human lung explants for omic analysis. Eur Respir J. 2020 01; 55(1).
journal title abbreviation: Eur Respir J
publication date: 2020-01-23T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 131772
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Endothelin: a new cardiovascular regulatory peptide.

Mallinckrodt Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Cardiology
sort order: 1
type: Position
HR job title: Mallinckrodt Professor of Medicine
position in organization: Brigham and Women's Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Brigham and Women's Hospital

Authorship 136250
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury.

Authorship 133508
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.

Authorship 1227924
type: Authorship
author rank in publication: 14
linked author: Perrella, Mark
linked information resource: Multipotency of mouse trophoblast stem cells.

Multipotency of mouse trophoblast stem cells.
PubMed Identifier: 32054514
author list: Hou M, Han J, Li G, Kwon MY, Jiang J, Emani S, Taglauer ES, Park JA, Choi EB, Vodnala M, Fong YW, Emani SM, Rosas IO, Perrella MA, Liu X
published in: Stem cell research & therapy
information resource reference: Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020 02 13; 11(1):55.
journal title abbreviation: Stem Cell Res Ther
publication date: 2020-02-13T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 161171
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.

Authorship 1234289
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.

Authorship 1233354
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions.

Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions.
PubMed Identifier: 32167239
author list: Kwon MY, Hwang N, Back SH, Lee SJ, Perrella MA, Chung SW
published in: The FEBS journal
information resource reference: Nucleotide-binding oligomerization domain protein 2 deficiency enhances CHOP expression and plaque necrosis in advanced atherosclerotic lesions. FEBS J. 2020 05; 287(10):2055-2069.
journal title abbreviation: FEBS J
publication date: 2020-03-30T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
PubMed Identifier: 32167490
author list: Kwon MY, Ghanta S, Ng J, Tsoyi K, Lederer JA, Bronson RT, El-Chemaly S, Chung SW, Liu X, Perrella MA
published in: Critical care medicine
information resource reference: Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis. Crit Care Med. 2020 05; 48(5):e409-e417.
journal title abbreviation: Crit Care Med
publication date: 2020-05-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial Infection
end date: 2025-01-31
principal investigator name: PERRELLA, MARK A
start date: 2020-04-01
type: Grant
sponsor award id: R01GM136804

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Mesenchymal Stromal Cells, Autophagy, and the Host Response to Systemic Bacterial Infection

Authorship 129116
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Akt participation in the Wnt signaling pathway through Dishevelled.

Authorship 1270787
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.

FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
PubMed Identifier: 32736525
author list: Shrestha S, Cho W, Stump B, Imani J, Lamattina AM, Louis PH, Pazzanese J, Rosas IO, Visner G, Perrella MA, El-Chemaly S
published in: Molecular medicine (Cambridge, Mass.)
information resource reference: FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 07 31; 26(1):75.
journal title abbreviation: Mol Med
publication date: 2020-07-31T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 182520
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Natriuretic peptide system in human heart failure.

Authorship 214900
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Cardiac atrial natriuretic factor during evolution of congestive heart failure.

Authorship 201360
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter.

Authorship 148660
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.

Authorship 1297600
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis.

Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis.
PubMed Identifier: 33049055
author list: Ng J, Guo F, Marneth AE, Ghanta S, Kwon MY, Keegan J, Liu X, Wright KT, Kamaz B, Cahill LA, Mullally A, Perrella MA, Lederer JA
published in: Blood advances
information resource reference: Augmenting emergency granulopoiesis with CpG conditioned mesenchymal stromal cells in murine neutropenic sepsis. Blood Adv. 2020 10 13; 4(19):4965-4979.
journal title abbreviation: Blood Adv
publication date: 2020-10-13T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 137375
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

Authorship 154034
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression.

Authorship 1321883
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.

Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.
PubMed Identifier: 33438259
author list: Kwon MY, Ghanta S, Ng J, Castano AP, Han J, Ith B, Lederer JA, El-Chemaly S, Chung SW, Liu X, Perrella MA
published in: Journal of leukocyte biology
information resource reference: Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis. J Leukoc Biol. 2021 10; 110(4):711-722.
journal title abbreviation: J Leukoc Biol
publication date: 2021-01-13T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 155879
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses.

Authorship 1344961
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.

CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
PubMed Identifier: 33784491
author list: Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO
published in: American journal of respiratory and critical care medicine
information resource reference: CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 08 01; 204(3):312-325.
journal title abbreviation: Am J Respir Crit Care Med
publication date: 2021-08-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1358990
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Induction of Sepsis Via Fibrin Clot Implantation.

Induction of Sepsis Via Fibrin Clot Implantation.
PubMed Identifier: 34048004
author list: Ghanta S, Kwon MY, Perrella MA
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Induction of Sepsis Via Fibrin Clot Implantation. Methods Mol Biol. 2021; 2321:17-25.
journal title abbreviation: Methods Mol Biol
publication date: 2021-01-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 254060
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Upstream stimulatory factors regulate aortic preferentially expressed gene-1 expression in vascular smooth muscle cells.

Authorship 183904
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.

Authorship 1381672
type: Authorship
author rank in publication: 17
linked author: Perrella, Mark
linked information resource: Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.

Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
PubMed Identifier: 34355516
author list: Han J, Shi Y, Willis G, Imani J, Kwon MY, Li G, Ayaub E, Ghanta S, Ng J, Hwang N, Tsoyi K, El-Chemaly S, Kourembanas S, Mitsialis SA, Rosas IO, Liu X, Perrella MA
published in: The FEBS journal
information resource reference: Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation. FEBS J. 2022 01; 289(2):417-435.
journal title abbreviation: FEBS J
publication date: 2021-08-15T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1389670
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice.

Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice.
PubMed Identifier: 34461993
author list: Han J, Li G, Hou M, Ng J, Kwon MY, Xiong K, Liang X, Taglauer E, Shi Y, Mitsialis SA, Kourembanas S, El-Chemaly S, Lederer JA, Rosas IO, Perrella MA, Liu X
published in: Stem cell research & therapy
information resource reference: Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice. Stem Cell Res Ther. 2021 08 30; 12(1):487.
journal title abbreviation: Stem Cell Res Ther
publication date: 2021-08-30T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 174969
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.

Authorship 1405183
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: Blocking hyaluronan synthesis alleviates acute lung allograft rejection.

Blocking hyaluronan synthesis alleviates acute lung allograft rejection.
PubMed Identifier: 34665782
author list: Imani J, Liu K, Cui Y, Assaker JP, Han J, Ghosh AJ, Ng J, Shrestha S, Lamattina AM, Louis PH, Hentschel A, Esposito AJ, Rosas IO, Liu X, Perrella MA, Azzi J, Visner G, El-Chemaly S
published in: JCI insight
information resource reference: Blocking hyaluronan synthesis alleviates acute lung allograft rejection. JCI Insight. 2021 11 22; 6(22).
journal title abbreviation: JCI Insight
publication date: 2021-11-22T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1406186
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: The lung microbiome in end-stage Lymphangioleiomyomatosis.

Authorship 1406993
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues.

The lung microbiome in end-stage Lymphangioleiomyomatosis.
PubMed Identifier: 34702264
author list: Ng J, Pacheco-Rodriguez G, Begley L, Huang YJ, Poli S, Perrella MA, Rosas IO, Moss J, El-Chemaly S
published in: Respiratory research
information resource reference: The lung microbiome in end-stage Lymphangioleiomyomatosis. Respir Res. 2021 Oct 26; 22(1):277.
journal title abbreviation: Respir Res
publication date: 2021-10-26T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues.
PubMed Identifier: 9312272
author list: Ackers GK, Perrella M, Holt JM, Denisov I, Huang Y
published in: Biochemistry
information resource reference: Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues. Biochemistry. 1997 Sep 09; 36(36):10822-9.
journal title abbreviation: Biochemistry
publication date: 1997-09-09T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1422003
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Inflammasome activation in neutrophils of patients with severe COVID-19.

Inflammasome activation in neutrophils of patients with severe COVID-19.
PubMed Identifier: 34991159
author list: Aymonnier K, Ng J, Fredenburgh LE, Zambrano-Vera K, Münzer P, Gutch S, Fukui S, Desjardins M, Subramaniam M, Baron RM, Raby BA, Perrella MA, Lederer JA, Wagner DD
published in: Blood advances
information resource reference: Inflammasome activation in neutrophils of patients with severe COVID-19. Blood Adv. 2022 04 12; 6(7):2001-2013.
journal title abbreviation: Blood Adv
publication date: 2022-04-12T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 205109
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice.

Authorship 217805
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice.

Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
PubMed Identifier: 35181688
author list: Tsoyi K, Esposito AJ, Sun B, Bowen RG, Xiong K, Poli F, Cardenas R, Chu SG, Liang X, Ryter SW, Beeton C, Doyle TJ, Robertson MJ, Celada LJ, Romero F, El-Chemaly SY, Perrella MA, Ho IC, Rosas IO
published in: Scientific reports
information resource reference: Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts. Sci Rep. 2022 02 18; 12(1):2847.
journal title abbreviation: Sci Rep
publication date: 2022-02-18T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1434332
type: Authorship
author rank in publication: 17
linked author: Perrella, Mark
linked information resource: Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.

Authorship 1441278
type: Authorship
author rank in publication: 17
linked author: Perrella, Mark
linked information resource: ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.

ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.
PubMed Identifier: 35181635
author list: Shrestha S, Lamattina A, Pacheco-Rodriguez G, Ng J, Liu X, Sonawane A, Imani J, Qiu W, Kosmas K, Louis P, Hentschel A, Steagall WK, Onishi R, Christou H, Henske EP, Glass K, Perrella MA, Moss J, Tantisira K, El-Chemaly S
published in: Life science alliance
information resource reference: ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells. Life Sci Alliance. 2022 05; 5(5).
journal title abbreviation: Life Sci Alliance
publication date: 2022-02-18T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1468203
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.

Authorship 1466974
type: Authorship
author rank in publication: 14
linked author: Perrella, Mark
linked information resource: Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility.

Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
PubMed Identifier: 35763354
author list: Li Q, Lin J, Widrick JJ, Luo S, Li G, Zhang Y, Laporte J, Perrella MA, Liu X, Agrawal PB
published in: JCI insight
information resource reference: Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model. JCI Insight. 2022 08 08; 7(15).
journal title abbreviation: JCI Insight
publication date: 2022-08-08T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility.
PubMed Identifier: 35739508
author list: Imani J, Bodine SPM, Lamattina AM, Ma DD, Shrestha S, Maynard DM, Bishop K, Nwokeji A, Malicdan MCV, Testa LC, Sood R, Stump B, Rosas IO, Perrella MA, Handin R, Young LR, Gochuico BR, El-Chemaly S
published in: Respiratory research
information resource reference: Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility. Respir Res. 2022 Jun 23; 23(1):167.
journal title abbreviation: Respir Res
publication date: 2022-06-23T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 409471
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-beta1.

Authorship 416804
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition.

Authorship 1502408
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death.

Authorship 1488680
type: Authorship
author rank in publication: 21
linked author: Perrella, Mark
linked information resource: Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study.

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study.
PubMed Identifier: 36075242
author list: Solomon JJ, Danoff SK, Woodhead FA, Hurwitz S, Maurer R, Glaspole I, Dellaripa PF, Gooptu B, Vassallo R, Cox PG, Flaherty KR, Adamali HI, Gibbons MA, Troy L, Forrest IA, Lasky JA, Spencer LG, Golden J, Scholand MB, Chaudhuri N, Perrella MA, Lynch DA, Chambers DC, Kolb M, Spino C, Raghu G, Goldberg HJ, Rosas IO
published in: The Lancet. Respiratory medicine
information resource reference: Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study. Lancet Respir Med. 2023 01; 11(1):87-96.
journal title abbreviation: Lancet Respir Med
publication date: 2022-09-05T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death.
PubMed Identifier: 36220392
author list: Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S
published in: The Journal of biological chemistry
information resource reference: Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. J Biol Chem. 2022 11; 298(11):102580.
journal title abbreviation: J Biol Chem
publication date: 2022-10-08T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 223317
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice.

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 1561186
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex.

Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex.
PubMed Identifier: 37162921
author list: Li Q, Lin J, Luo S, Schmitz-Abe K, Agrawal R, Meng M, Moghadaszadeh B, Beggs AH, Liu X, Perrella MA, Agrawal PB
published in: bioRxiv : the preprint server for biology
information resource reference: Integrated multi-omics approach reveals the role of SPEG in skeletal muscle biology including its relationship with myospryn complex. bioRxiv. 2023 Apr 24.
journal title abbreviation: bioRxiv
publication date: 2023-04-24T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 228820
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Plasma gelsolin is a marker and therapeutic agent in animal sepsis.

Authorship 1594200
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells.

Authorship 1595126
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Identification and targeting of microbial putrescine acetylation in bloodstream infections.

Identification and targeting of microbial putrescine acetylation in bloodstream infections.
PubMed Identifier: 37790300
author list: Mayers JR, Varon J, Zhou RR, Daniel-Ivad M, Beaulieu C, Bholse A, Glasser NR, Lichtenauer FM, Ng J, Vera MP, Huttenhower C, Perrella MA, Clish CB, Zhao SD, Baron RM, Balskus EP
published in: bioRxiv : the preprint server for biology
information resource reference: Identification and targeting of microbial putrescine acetylation in bloodstream infections. bioRxiv. 2023 Sep 21.
journal title abbreviation: bioRxiv
publication date: 2023-09-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells.
PubMed Identifier: 37797588
author list: Ng J, Marneth AE, Griffith A, Younger D, Ghanta S, Jiao A, Willis G, Han J, Imani J, Niu B, Keegan JW, Hancock B, Guo F, Shi Y, Perrella MA, Lederer JA
published in: Journal of innate immunity
information resource reference: Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells. J Innate Immun. 2023; 15(1):765-781.
journal title abbreviation: J Innate Immun
publication date: 2023-10-05T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 426973
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.

Authorship 1616802
type: Authorship
author rank in publication: 14
linked author: Perrella, Mark
linked information resource: Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.

Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.
PubMed Identifier: 38145999
author list: Li G, Huang H, Wu Y, Shu C, Hwang N, Li Q, Zhao R, Lam HC, Oldham WM, Ei-Chemaly S, Agrawal PB, Tian J, Liu X, Perrella MA
published in: Basic research in cardiology
information resource reference: Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes. Basic Res Cardiol. 2024 02; 119(1):151-168.
journal title abbreviation: Basic Res Cardiol
publication date: 2023-12-26T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 561346
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Heme oxygenase-1: a novel drug target for atherosclerotic diseases?

Adult and neonatal models of chemogenetic heart failure caused by oxidative stress.
PubMed Identifier: 38483521
author list: Spyropoulos F, Das AA, Waldeck-Weiermair M, Yadav S, Pandey AK, Guo R, Covington TA, Thulabandu V, Kosmas K, Steinhorn B, Perrella MA, Liu X, Christou H, Michel T
published in: The Journal of clinical investigation
information resource reference: Adult and neonatal models of chemogenetic heart failure caused by oxidative stress. J Clin Invest. 2024 Mar 14; 134(9).
journal title abbreviation: J Clin Invest
publication date: 2024-03-14T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.
PubMed Identifier: 38514093
author list: Liu T, Liu S, Rui X, Cao Y, Hecker J, Guo F, Zhang Y, Gong L, Zhou Y, Yu Y, Krishnamoorthyni N, Bates S, Chun S, Boyer N, Xu S, Park JA, Perrella MA, Levy BD, Weiss ST, Mou H, Raby BA, Zhou X
published in: The European respiratory journal
information resource reference: Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation. Eur Respir J. 2024 May; 63(5).
journal title abbreviation: Eur Respir J
publication date: 2024-05-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1636032
type: Authorship
author rank in publication: 17
linked author: Perrella, Mark
linked information resource: Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.

Authorship 255132
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.

Authorship 1650889
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Adult and neonatal models of chemogenetic heart failure caused by oxidative stress.

Authorship 1647577
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex.

Authorship 1651852
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Carbon monoxide-induced autophagy enhances human mesenchymal stromal cell function via paracrine actions in murine polymicrobial sepsis.

Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex.
PubMed Identifier: 38725372
author list: Li Q, Lin J, Luo S, Schmitz-Abe K, Agrawal R, Meng M, Moghadaszadeh B, Beggs AH, Liu X, Perrella MA, Agrawal PB
published in: Journal of cachexia, sarcopenia and muscle
information resource reference: Integrated multi-omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex. J Cachexia Sarcopenia Muscle. 2024 Jun; 15(3):1003-1015.
journal title abbreviation: J Cachexia Sarcopenia Muscle
publication date: 2024-05-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Carbon monoxide-induced autophagy enhances human mesenchymal stromal cell function via paracrine actions in murine polymicrobial sepsis.
PubMed Identifier: 38734903
author list: Hwang N, Ghanta S, Li Q, Lamattina AM, Murzin E, Lederer JA, El-Chemaly S, Chung SW, Liu X, Perrella MA
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Carbon monoxide-induced autophagy enhances human mesenchymal stromal cell function via paracrine actions in murine polymicrobial sepsis. Mol Ther. 2024 Jul 03; 32(7):2232-2247.
journal title abbreviation: Mol Ther
publication date: 2024-05-11T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1662977
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: A metabolomics pipeline highlights microbial metabolism in bloodstream infections.

A metabolomics pipeline highlights microbial metabolism in bloodstream infections.
PubMed Identifier: 38885650
author list: Mayers JR, Varon J, Zhou RR, Daniel-Ivad M, Beaulieu C, Bhosle A, Glasser NR, Lichtenauer FM, Ng J, Vera MP, Huttenhower C, Perrella MA, Clish CB, Zhao SD, Baron RM, Balskus EP
published in: Cell
information resource reference: A metabolomics pipeline highlights microbial metabolism in bloodstream infections. Cell. 2024 Jul 25; 187(15):4095-4112.e21.
journal title abbreviation: Cell
publication date: 2024-06-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 353171
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.

Simon Gelman Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Simon Gelman Professor of Anaesthesia
position in organization: Brigham and Women's Hospital

Associate Professor of Population Medicine
is primary position: true
position in department: Population Medicine
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Population Medicine
position in organization: Brigham and Women's Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Associate Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Surgery
position in organization: Brigham and Women's Hospital

Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Surgery
position in organization: Beth Israel Deaconess Medical Center

Authorship 434650
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.

Mary Ellen Avery Associate Professor of Pediatrics in the Field of Newborn Medicine
is primary position: true
position in department: Pediatrics
position in division: Newborn Medicine
sort order: 1
type: Position
HR job title: Mary Ellen Avery Associate Professor of Pediatrics in the Field of Newborn Medicine
position in organization: Brigham and Women's Hospital

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 650934
type: Authorship
author rank in publication: 18
linked author: Perrella, Mark
linked information resource: Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.

Authorship 366707
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: ANF-mediated renal cGMP generation in congestive heart failure.

Stress Granule Assembly in Pulmonary Arterial Hypertension.
PubMed Identifier: 39513903
author list: Kosmas K, Papathanasiou AE, Spyropoulos F, Rehman R, Cunha AA, Fredenburgh LE, Perrella MA, Christou H
published in: Cells
information resource reference: Stress Granule Assembly in Pulmonary Arterial Hypertension. Cells. 2024 10 30; 13(21).
journal title abbreviation: Cells
publication date: 2024-10-30T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1705806
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Stress Granule Assembly in Pulmonary Arterial Hypertension.

Authorship 72955
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice.

Authorship 184196
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene.

Authorship 91809
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor.

Authorship 212975
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/830397

Authorship 24230
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: The role of heme oxygenase-1 in pulmonary disease.

Authorship 274314
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Molecular mechanisms of morning onset of myocardial infarction.

c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.
PubMed Identifier: 24170267
author list: Sanada F, Kim J, Czarna A, Chan NY, Signore S, Ogórek B, Isobe K, Wybieralska E, Borghetti G, Pesapane A, Sorrentino A, Mangano E, Cappetta D, Mangiaracina C, Ricciardi M, Cimini M, Ifedigbo E, Perrella MA, Goichberg P, Choi AM, Kajstura J, Hosoda T, Rota M, Anversa P, Leri A
published in: Circulation research
information resource reference: c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res. 2014 Jan 03; 114(1):41-55.
journal title abbreviation: Circ Res
publication date: 2013-10-29T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 223553
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.

Authorship 257021
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.

Authorship 700404
type: Authorship
author rank in publication: 18
linked author: Perrella, Mark
linked information resource: c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.

PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension.
PubMed Identifier: 40548907
author list: Rehman R, Dieffenbach P, Vellarikkal SK, Corcoran AM, Pomales L, Arciniegas Rubio A, Zambrano Vera KV, Spyropoulos F, Kosmas K, Lam H, Filippakis H, Perrella MA, Fredenburgh LE, Christou H
published in: American journal of respiratory cell and molecular biology
information resource reference: PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2025 Dec; 73(6):859-870.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2025-12-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 704074
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.

Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis.
PubMed Identifier: 23971531
author list: Lee S, Lee SJ, Coronata AA, Fredenburgh LE, Chung SW, Perrella MA, Nakahira K, Ryter SW, Choi AM
published in: Antioxidants & redox signaling
information resource reference: Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. Antioxid Redox Signal. 2014 Jan 20; 20(3):432-42.
journal title abbreviation: Antioxid Redox Signal
publication date: 2013-10-05T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 302138
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein.

Authorship 309957
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Role of TGF-beta in vascular development and vascular reactivity.

Authorship 418473
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells.

Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice.
PubMed Identifier: 40691621
author list: Hwang N, Li G, Murzin E, Mays CJ, Lederer JA, Liu X, Perrella MA
published in: Stem cell research & therapy
information resource reference: Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice. Stem Cell Res Ther. 2025 Jul 21; 16(1):394.
journal title abbreviation: Stem Cell Res Ther
publication date: 2025-07-21T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 334385
type: Authorship
author rank in publication: 19
linked author: Perrella, Mark
linked information resource: Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.

Authorship 329517
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.

Authorship 208083
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.

Cellular Therapy for Sepsis and Lung Injury
end date: 2030-12-31
principal investigator name: PERRELLA, MARK A
start date: 2026-03-05
type: Grant
sponsor award id: R35GM161257

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Cellular Therapy for Sepsis and Lung Injury

Authorship 1780230
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice.

Authorship 1782964
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension.

Authorship 1844277
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis.

Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis.
PubMed Identifier: 40475431
author list: Misra A, Weitman EM, Weitman M, Brook JR, Rone JM, Petrova B, Mertens RT, Hwang N, Vera KZ, Perrella MA, Baron RM, Kanarek N, Nowarski R
published in: bioRxiv : the preprint server for biology
information resource reference: Branched-chain ketoacid antioxidants mediate disease tolerance to sepsis. bioRxiv. 2025 May 22.
journal title abbreviation: bioRxiv
publication date: 2025-05-22T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Newborn Medicine
type: Division
type: Organization

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Newborn Medicine
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Brigham and Women's Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Pulmonary
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 39645
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Heme oxygenase 1 in regulation of inflammation and oxidative damage.

Associate Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Surgery
position in organization: Boston Children's Hospital

SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
PubMed Identifier: 25087613
author list: Agrawal PB, Pierson CR, Joshi M, Liu X, Ravenscroft G, Moghadaszadeh B, Talabere T, Viola M, Swanson LC, Haliloglu G, Talim B, Yau KS, Allcock RJ, Laing NG, Perrella MA, Beggs AH
published in: American journal of human genetics
information resource reference: SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy. Am J Hum Genet. 2014 Aug 07; 95(2):218-26.
journal title abbreviation: Am J Hum Genet
publication date: 2014-07-31T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 38504
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators.

Authorship 753959
type: Authorship
author rank in publication: 22
linked author: Perrella, Mark
linked information resource: Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.

Authorship 750118
type: Authorship
author rank in publication: 15
linked author: Perrella, Mark
linked information resource: SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.

Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.
PubMed Identifier: 25054455
author list: Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS
published in: American journal of respiratory and critical care medicine
information resource reference: Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):445-55.
journal title abbreviation: Am J Respir Crit Care Med
publication date: 2014-08-15T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 509222
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro.

Authorship 400293
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function.

Authorship 459630
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif.

Authorship 455070
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin.

Authorship 777790
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.

Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
PubMed Identifier: 25351511
author list: Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA
published in: Journal of leukocyte biology
information resource reference: Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol. 2015 Jan; 97(1):171-80.
journal title abbreviation: J Leukoc Biol
publication date: 2014-10-28T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 73360
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells.

Authorship 543414
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs.

Authorship 554654
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
PubMed Identifier: 25825391
author list: White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY
published in: EMBO molecular medicine
information resource reference: Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713.
journal title abbreviation: EMBO Mol Med
publication date: 2015-06-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 71736
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.

Authorship 416042
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.

Authorship 421997
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1.

Authorship 384400
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia.

Authorship 443332
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Role of haem oxygenase-1 in microbial host defence.

Authorship 49419
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages.

Authorship 493647
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: PU.1 regulates cathepsin S expression in professional APCs.

Authorship 397727
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.

Authorship 556626
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

Authorship 501278
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

Authorship 28460
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes.

Authorship 458617
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer.

Authorship 502504
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death.

Authorship 77887
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.

Authorship 272276
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Transforming growth factor-ß1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2.

Authorship 245160
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury.

Authorship 364904
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells.

Authorship 238856
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development.

Authorship 322843
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Pseudoaneurysm of the aortic root diagnosed by noninvasive imaging: report of a case.

Authorship 43023
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils.

Authorship 218179
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels.

Authorship 434080
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals.

Authorship 278260
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Endotoxin-induced down-regulation of Elk-3 facilitates heme oxygenase-1 induction in macrophages.

Authorship 514997
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia.

Authorship 202780
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.
PubMed Identifier: 25763110
author list: Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X
published in: Genome medicine
information resource reference: Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015; 7(1):12.
journal title abbreviation: Genome Med
publication date: 2015-02-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 71791
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Lung biopsy.

Authorship 78230
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice.

Authorship 334248
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Role of HO-1 in renoprotection: location, location, location.

Authorship 386914
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure.

Authorship 390521
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.

Authorship 213255
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: Increased endothelin in experimental heart failure.

Authorship 328427
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells.

Authorship 434358
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility.

Authorship 503782
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

Authorship 333569
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Pathobiology of sepsis: are we still asking the same questions?

Authorship 360044
type: Authorship
author rank in publication: 4
linked author: Perrella, Mark
linked information resource: A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia.

Authorship 395489
type: Authorship
author rank in publication: 14
linked author: Perrella, Mark
linked information resource: Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.

Authorship 571451
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia.

Authorship 805713
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

Authorship 789570
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.

Authorship 245350
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells.

Authorship 284341
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.

Authorship 491434
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Heme oxygenase-1: a multifaceted triple-threat molecule.

Authorship 549882
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).

Authorship 289937
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.

Authorship 348961
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.

Authorship 381100
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice.

Authorship 436152
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells.

Authorship 515648
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Arrest of endotoxin-induced hypotension by transforming growth factor beta1.

Authorship 74241
type: Authorship
author rank in publication: 22
linked author: Perrella, Mark
linked information resource: Evidence for human lung stem cells.

Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection.
PubMed Identifier: 26485284
author list: Cui Y, Liu K, Monzon-Medina ME, Padera RF, Wang H, George G, Toprak D, Abdelnour E, D'Agostino E, Goldberg HJ, Perrella MA, Forteza RM, Rosas IO, Visner G, El-Chemaly S
published in: The Journal of clinical investigation
information resource reference: Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68.
journal title abbreviation: J Clin Invest
publication date: 2015-10-20T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 440445
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure.

Authorship 843481
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection.

Authorship 846733
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.

Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.
PubMed Identifier: 26593099
author list: Liu X, Hall SRR, Wang Z, Huang H, Ghanta S, Di Sante M, Leri A, Anversa P, Perrella MA
published in: Nature communications
information resource reference: Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero. Nat Commun. 2015 Nov 23; 6:8825.
journal title abbreviation: Nat Commun
publication date: 2015-11-23T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin.
PubMed Identifier: 26862784
author list: Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X
published in: American journal of respiratory and critical care medicine
information resource reference: A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97.
journal title abbreviation: Am J Respir Crit Care Med
publication date: 2016-07-15T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 352516
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 99643
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Role of heme oxygenase-1 in cardiovascular function.

Authorship 574182
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat.

Authorship 892866
type: Authorship
author rank in publication: 17
linked author: Perrella, Mark
linked information resource: A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin.

Authorship 548914
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling.

Authorship 897014
type: Authorship
author rank in publication: 12
linked author: Perrella, Mark
linked information resource: Hhip haploinsufficiency sensitizes mice to age-related emphysema.

Hhip haploinsufficiency sensitizes mice to age-related emphysema.
PubMed Identifier: 27444019
author list: Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4681-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2016-07-21T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 474367
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine.

Authorship 510101
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.

CYTOKINE REGULATION OF VASCULAR SMOOTH MUSCLE CELL NOS
end date: 2000-01-31
principal investigator name: PERRELLA, MARK A
start date: 1996-02-01
type: Grant
sponsor award id: K08HL003194

DNA Minor Groove-binding Drugs and Food-borne Pathogens
end date: 2010-11-30
principal investigator name: PERRELLA, MARK A
start date: 2004-12-15
type: Grant
sponsor award id: U01AI061246

Nitric Oxide Synthase 2 in Endotoxemia and Sepsis
end date: 2010-06-30
principal investigator name: PERRELLA, MARK A
start date: 1995-08-01
type: Grant
sponsor award id: R01GM053249

Role of APEG-1 in Vascular Smooth Muscle Biology
end date: 2007-02-28
principal investigator name: PERRELLA, MARK A
start date: 2001-04-01
type: Grant
sponsor award id: R01HL065639

Role of Heme Oxygenase-1 in Sepsis
end date: 2012-06-30
principal investigator name: PERRELLA, MARK A
start date: 1998-07-01
type: Grant
sponsor award id: R01HL060788

Cardiomyocyte Differentiation Regulates Cardiac Function
end date: 2015-11-30
principal investigator name: PERRELLA, MARK A
start date: 2010-12-02
type: Grant
sponsor award id: R01HL102897

Carbon Monoxide: Novel Opportunities for Therapy
end date: 2017-06-30
principal investigator name: PERRELLA, MARK A
start date: 2011-08-15
type: Grant
sponsor award id: P01HL108801

Regulation of Neutrophil Function by Mesenchymal Stromal Cells During Sepsis
end date: 2021-02-28
principal investigator name: PERRELLA, MARK A
start date: 2016-05-10
type: Grant
sponsor award id: R01GM118456

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: CYTOKINE REGULATION OF VASCULAR SMOOTH MUSCLE CELL NOS

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Role of APEG-1 in Vascular Smooth Muscle Biology

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Cardiomyocyte Differentiation Regulates Cardiac Function

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Nitric Oxide Synthase 2 in Endotoxemia and Sepsis

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: DNA Minor Groove-binding Drugs and Food-borne Pathogens

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Carbon Monoxide: Novel Opportunities for Therapy

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Regulation of Neutrophil Function by Mesenchymal Stromal Cells During Sepsis

Principal Investigator
type: Researcher Role
researcher role of: Perrella, Mark
contributes to: Role of Heme Oxygenase-1 in Sepsis

Authorship 8900
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.

Authorship 353222
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.

Authorship 921364
type: Authorship
author rank in publication: 13
linked author: Perrella, Mark
linked information resource: Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.

Authorship 922698
type: Authorship
author rank in publication: 11
linked author: Perrella, Mark
linked information resource: Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
PubMed Identifier: 27636016
author list: Ghanta S, Tsoyi K, Liu X, Nakahira K, Ith B, Coronata AA, Fredenburgh LE, Englert JA, Piantadosi CA, Choi AM, Perrella MA
published in: American journal of respiratory cell and molecular biology
information resource reference: Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction. Am J Respir Cell Mol Biol. 2017 03; 56(3):300-309.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2017-03-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.
PubMed Identifier: 27513357
author list: Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MA
published in: Critical care medicine
information resource reference: Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245.
journal title abbreviation: Crit Care Med
publication date: 2016-12-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 536985
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C/EBPalpha to increase expression.

Authorship 78370
type: Authorship
author rank in publication: 1
linked author: Perrella, Mark
linked information resource: Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function.

Authorship 245984
type: Authorship
author rank in publication: 3
linked author: Perrella, Mark
linked information resource: Increased production of nitric oxide in coronary arteries during congestive heart failure.

Authorship 255809
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

Authorship 497196
type: Authorship
author rank in publication: 6
linked author: Perrella, Mark
linked information resource: Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.

Authorship 535713
type: Authorship
author rank in publication: 7
linked author: Perrella, Mark
linked information resource: Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression.

Authorship 957397
type: Authorship
author rank in publication: 2
linked author: Perrella, Mark
linked information resource: Interleukin 10 and transforming growth factor beta 1 in hepatic fibrosis.

Interleukin 10 and transforming growth factor beta 1 in hepatic fibrosis.
PubMed Identifier: 12575926
author list: Perrella O, Perrella M, Cusumano V, Ibello U, Sbreglia C, De Sena R, Perrella A
published in: International journal of immunopathology and pharmacology
information resource reference: Interleukin 10 and transforming growth factor beta 1 in hepatic fibrosis. Int J Immunopathol Pharmacol. 2002 Sep-Dec; 15(3):243-244.
journal title abbreviation: Int J Immunopathol Pharmacol
publication date: 2002-09-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.
PubMed Identifier: 8755661
author list: Patterson C, Perrella MA, Endege WO, Yoshizumi M, Lee ME, Haber E
published in: The Journal of clinical investigation
information resource reference: Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J Clin Invest. 1996 Jul 15; 98(2):490-6.
journal title abbreviation: J Clin Invest
publication date: 1996-07-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock.
PubMed Identifier: 9020147
author list: Yet SF, Pellacani A, Patterson C, Tan L, Folta SC, Foster L, Lee WS, Hsieh CM, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock. J Biol Chem. 1997 Feb 14; 272(7):4295-301.
journal title abbreviation: J Biol Chem
publication date: 1997-02-14T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/748450
PubMed Identifier: 9268374
author list: Yoshizumi M, Wang H, Hsieh CM, Sibinga NE, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein. J Biol Chem. 1997 Aug 29; 272(35):22259-64.
journal title abbreviation: J Biol Chem
publication date: 1997-08-29T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein.

Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice.
PubMed Identifier: 11113055
author list: Wiesel P, Patel AP, DiFonzo N, Marria PB, Sim CU, Pellacani A, Maemura K, LeBlanc BW, Marino K, Doerschuk CM, Yet SF, Lee ME, Perrella MA
published in: Circulation
information resource reference: Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice. Circulation. 2000 Dec 12; 102(24):3015-22.
journal title abbreviation: Circulation
publication date: 2000-12-12T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death.
PubMed Identifier: 12738799
author list: Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen YH, Vom Saal J, Levy BD, Yet SF, Perrella MA
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J. 2003 Jul; 17(10):1325-7.
journal title abbreviation: FASEB J
publication date: 2003-05-08T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications.
PubMed Identifier: 1838025
author list: Perrella MA, Margulies KB, Burnett JC
published in: Canadian journal of physiology and pharmacology
information resource reference: Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications. Can J Physiol Pharmacol. 1991 Oct; 69(10):1576-81.
journal title abbreviation: Can J Physiol Pharmacol
publication date: 1991-10-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.
PubMed Identifier: 15356165
author list: Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53.
journal title abbreviation: J Immunol
publication date: 2004-09-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Lung biopsy.
PubMed Identifier: 1558001
author list: Utz JP, Perrella MA, Rosenow EC
published in: Advances in internal medicine
information resource reference: Lung biopsy. Adv Intern Med. 1992; 37:337-61.
journal title abbreviation: Adv Intern Med
publication date: 1992-01-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages.
PubMed Identifier: 10825169
author list: Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Transforming growth factor-beta 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J Biol Chem. 2000 Aug 18; 275(33):25766-73.
journal title abbreviation: J Biol Chem
publication date: 2000-08-18T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 966607
type: Authorship
author rank in publication: 8
linked author: Perrella, Mark
linked information resource: Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.

Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways.
PubMed Identifier: 28248572
author list: Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP
published in: American journal of respiratory cell and molecular biology
information resource reference: Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 07; 57(1):47-58.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2017-07-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Pathobiology of sepsis: are we still asking the same questions?
PubMed Identifier: 16421210
author list: Baron RM, Baron MJ, Perrella MA
published in: American journal of respiratory cell and molecular biology
information resource reference: Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol. 2006 Feb; 34(2):129-34.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2006-02-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury.
PubMed Identifier: 9118484
author list: Sibinga NE, Foster LC, Hsieh CM, Perrella MA, Lee WS, Endege WO, Sage EH, Lee ME, Haber E
published in: Circulation research
information resource reference: Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. Circ Res. 1997 Apr; 80(4):532-41.
journal title abbreviation: Circ Res
publication date: 1997-04-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).
PubMed Identifier: 9545312
author list: Chin MT, Pellacani A, Wang H, Lin SS, Jain MK, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). J Biol Chem. 1998 Apr 17; 273(16):9755-60.
journal title abbreviation: J Biol Chem
publication date: 1998-04-17T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro.
PubMed Identifier: 10640447
author list: Chin MT, Pellacani A, Hsieh CM, Lin SS, Jain MK, Patel A, Huggins GS, Reeves R, Perrella MA, Lee ME
published in: Journal of molecular and cellular cardiology
information resource reference: Induction of high mobility group I architectural transcription factors in proliferating vascular smooth muscle in vivo and in vitro. J Mol Cell Cardiol. 1999 Dec; 31(12):2199-205.
journal title abbreviation: J Mol Cell Cardiol
publication date: 1999-12-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.
PubMed Identifier: 19118250
author list: Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA
published in: Circulation
information resource reference: Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8.
journal title abbreviation: Circulation
publication date: 2008-12-31T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia.
PubMed Identifier: 11447290
author list: Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-07-10T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia.
PubMed Identifier: 1636793
author list: Perrella MA, Edell ES, Krowka MJ, Cortese DA, Burnett JC
published in: The American journal of physiology
information resource reference: Endothelium-derived relaxing factor in pulmonary and renal circulations during hypoxia. Am J Physiol. 1992 Jul; 263(1 Pt 2):R45-50.
journal title abbreviation: Am J Physiol
publication date: 1992-07-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development.
PubMed Identifier: 15749083
author list: Ith B, Wei J, Yet SF, Perrella MA, Layne MD
published in: Gene expression patterns : GEP
information resource reference: Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development. Gene Expr Patterns. 2005 Apr; 5(4):533-7.
journal title abbreviation: Gene Expr Patterns
publication date: 2004-12-08T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
PubMed Identifier: 10531360
author list: Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem. 1999 Oct 29; 274(44):31565-70.
journal title abbreviation: J Biol Chem
publication date: 1999-10-29T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.
PubMed Identifier: 11463724
author list: Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA
published in: Circulation research
information resource reference: Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001 Jul 20; 89(2):168-73.
journal title abbreviation: Circ Res
publication date: 2001-07-20T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 976130
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Transforming growth factor ß1 (TGFß1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.

Transforming growth factor ß1 (TGFß1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.
PubMed Identifier: 28389562
author list: Ghatak S, Markwald RR, Hascall VC, Dowling W, Lottes RG, Baatz JE, Beeson G, Beeson CC, Perrella MA, Thannickal VJ, Misra S
published in: The Journal of biological chemistry
information resource reference: Transforming growth factor ß1 (TGFß1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem. 2017 06 23; 292(25):10465-10489.
journal title abbreviation: J Biol Chem
publication date: 2017-04-07T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice.
PubMed Identifier: 15345145
author list: Ejima K, Perrella MA
published in: Antioxidants & redox signaling
information resource reference: Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice. Antioxid Redox Signal. 2004 Oct; 6(5):850-7.
journal title abbreviation: Antioxid Redox Signal
publication date: 2004-10-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.
PubMed Identifier: 9880529
author list: Pellacani A, Chin MT, Wiesel P, Ibanez M, Patel A, Yet SF, Hsieh CM, Paulauskis JD, Reeves R, Lee ME, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase. J Biol Chem. 1999 Jan 15; 274(3):1525-32.
journal title abbreviation: J Biol Chem
publication date: 1999-01-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1.
PubMed Identifier: 10973969
author list: Hsieh CM, Fukumoto S, Layne MD, Maemura K, Charles H, Patel A, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1. J Biol Chem. 2000 Nov 24; 275(47):36966-73.
journal title abbreviation: J Biol Chem
publication date: 2000-11-24T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses.
PubMed Identifier: 11782559
author list: Carvajal IM, Baron RM, Perrella MA
published in: Critical care medicine
information resource reference: High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Suppl):S36-42.
journal title abbreviation: Crit Care Med
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function.
PubMed Identifier: 1877690
author list: Perrella MA, Hildebrand FL, Margulies KB, Burnett JC
published in: The American journal of physiology
information resource reference: Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function. Am J Physiol. 1991 Aug; 261(2 Pt 2):R323-8.
journal title abbreviation: Am J Physiol
publication date: 1991-08-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia.
PubMed Identifier: 15522193
author list: Bishop A, Yet SF, Lee ME, Perrella MA, Demple B
published in: Biochemical and biophysical research communications
information resource reference: A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. Biochem Biophys Res Commun. 2004 Dec 03; 325(1):3-9.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2004-12-03T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.
PubMed Identifier: 10207174
author list: Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME
published in: The Journal of clinical investigation
information resource reference: Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9.
journal title abbreviation: J Clin Invest
publication date: 1999-04-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelin: a new cardiovascular regulatory peptide.
PubMed Identifier: 2232899
author list: Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC
published in: Mayo Clinic proceedings
information resource reference: Endothelin: a new cardiovascular regulatory peptide. Mayo Clin Proc. 1990 Nov; 65(11):1441-55.
journal title abbreviation: Mayo Clin Proc
publication date: 1990-11-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein.
PubMed Identifier: 11438679
author list: Layne MD, Yet SF, Maemura K, Hsieh CM, Bernfield M, Perrella MA, Lee ME
published in: Molecular and cellular biology
information resource reference: Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein. Mol Cell Biol. 2001 Aug; 21(15):5256-61.
journal title abbreviation: Mol Cell Biol
publication date: 2001-08-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression.
PubMed Identifier: 11970993
author list: Storm van's Gravesande K, Layne MD, Ye Q, Le L, Baron RM, Perrella MA, Santambrogio L, Silverman ES, Riese RJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. J Immunol. 2002 May 01; 168(9):4488-94.
journal title abbreviation: J Immunol
publication date: 2002-05-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function.
PubMed Identifier: 12709567
author list: Chen YH, Yet SF, Perrella MA
published in: Experimental biology and medicine (Maywood, N.J.)
information resource reference: Role of heme oxygenase-1 in the regulation of blood pressure and cardiac function. Exp Biol Med (Maywood). 2003 May; 228(5):447-53.
journal title abbreviation: Exp Biol Med (Maywood)
publication date: 2003-05-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin.
PubMed Identifier: 15590657
author list: Chung SW, Chen YH, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin. J Biol Chem. 2005 Feb 11; 280(6):4578-84.
journal title abbreviation: J Biol Chem
publication date: 2004-12-07T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter.
PubMed Identifier: 10207041
author list: Sibinga NE, Wang H, Perrella MA, Endege WO, Patterson C, Yoshizumi M, Haber E, Lee ME
published in: The Journal of biological chemistry
information resource reference: Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter. J Biol Chem. 1999 Apr 23; 274(17):12139-46.
journal title abbreviation: J Biol Chem
publication date: 1999-04-23T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals.
PubMed Identifier: 10974035
author list: DiChiara MR, Kiely JM, Gimbrone MA, Lee ME, Perrella MA, Topper JN
published in: The Journal of experimental medicine
information resource reference: Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals. J Exp Med. 2000 Sep 04; 192(5):695-704.
journal title abbreviation: J Exp Med
publication date: 2000-09-04T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Akt participation in the Wnt signaling pathway through Dishevelled.
PubMed Identifier: 11278246
author list: Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem. 2001 May 18; 276(20):17479-83.
journal title abbreviation: J Biol Chem
publication date: 2001-03-09T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression.
PubMed Identifier: 12230868
author list: Ejima K, Layne MD, Carvajal IM, Nanri H, Ith B, Yet SF, Perrella MA
published in: Antioxidants & redox signaling
information resource reference: Modulation of the thioredoxin system during inflammatory responses and its effect on heme oxygenase-1 expression. Antioxid Redox Signal. 2002 Aug; 4(4):569-75.
journal title abbreviation: Antioxid Redox Signal
publication date: 2002-08-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.
PubMed Identifier: 12896968
author list: Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Elk-3 is a transcriptional repressor of nitric-oxide synthase 2. J Biol Chem. 2003 Oct 10; 278(41):39572-7.
journal title abbreviation: J Biol Chem
publication date: 2003-07-31T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of heme oxygenase-1 in cardiovascular function.
PubMed Identifier: 14529547
author list: Perrella MA, Yet SF
published in: Current pharmaceutical design
information resource reference: Role of heme oxygenase-1 in cardiovascular function. Curr Pharm Des. 2003; 9(30):2479-87.
journal title abbreviation: Curr Pharm Des
publication date: 2003-01-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

ANF-mediated renal cGMP generation in congestive heart failure.
PubMed Identifier: 1849364
author list: Margulies KB, Heublein DM, Perrella MA, Burnett JC
published in: The American journal of physiology
information resource reference: ANF-mediated renal cGMP generation in congestive heart failure. Am J Physiol. 1991 Apr; 260(4 Pt 2):F562-8.
journal title abbreviation: Am J Physiol
publication date: 1991-04-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.
PubMed Identifier: 15208261
author list: Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8.
journal title abbreviation: FASEB J
publication date: 2004-06-18T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.
PubMed Identifier: 9422764
author list: Yet SF, McA'Nulty MM, Folta SC, Yen HW, Yoshizumi M, Hsieh CM, Layne MD, Chin MT, Wang H, Perrella MA, Jain MK, Lee ME
published in: The Journal of biological chemistry
information resource reference: Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem. 1998 Jan 09; 273(2):1026-31.
journal title abbreviation: J Biol Chem
publication date: 1998-01-09T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/830397
PubMed Identifier: 15029230
author list: Agrawal RS, Muangman S, Layne MD, Melo L, Perrella MA, Lee RT, Zhang L, Lopez-Ilasaca M, Dzau VJ
published in: Gene therapy
information resource reference: Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. Gene Ther. 2004 Jun; 11(12):962-9.
journal title abbreviation: Gene Ther
publication date: 2004-06-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival.

Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells.
PubMed Identifier: 18391113
author list: Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA
published in: Circulation
information resource reference: Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22.
journal title abbreviation: Circulation
publication date: 2008-04-07T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators.
PubMed Identifier: 10823822
author list: Wiesel P, Foster LC, Pellacani A, Layne MD, Hsieh CM, Huggins GS, Strauss P, Yet SF, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Thioredoxin facilitates the induction of heme oxygenase-1 in response to inflammatory mediators. J Biol Chem. 2000 Aug 11; 275(32):24840-6.
journal title abbreviation: J Biol Chem
publication date: 2000-08-11T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1.
PubMed Identifier: 11056164
author list: Pellacani A, Wiesel P, Razavi S, Vasilj V, Feinberg MW, Chin MT, Reeves R, Perrella MA
published in: The Journal of biological chemistry
information resource reference: Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1. J Biol Chem. 2001 Jan 12; 276(2):1653-9.
journal title abbreviation: J Biol Chem
publication date: 2001-01-12T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling.
PubMed Identifier: 12958201
author list: Yet SF, Layne MD, Liu X, Chen YH, Ith B, Sibinga NE, Perrella MA
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J. 2003 Sep; 17(12):1759-61.
journal title abbreviation: FASEB J
publication date: 2003-07-03T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 994346
type: Authorship
author rank in publication: 9
linked author: Perrella, Mark
linked information resource: Evidence for a retinal progenitor cell in the postnatal and adult mouse.

Evidence for a retinal progenitor cell in the postnatal and adult mouse.
PubMed Identifier: 28672156
author list: Chen X, Wang S, Xu H, Pereira JD, Hatzistergos KE, Saur D, Seidler B, Hare JM, Perrella MA, Yin ZQ, Liu X
published in: Stem cell research
information resource reference: Evidence for a retinal progenitor cell in the postnatal and adult mouse. Stem Cell Res. 2017 08; 23:20-32.
journal title abbreviation: Stem Cell Res
publication date: 2017-06-24T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of heme oxygenase-1 in pulmonary disease.
PubMed Identifier: 16980551
author list: Fredenburgh LE, Perrella MA, Mitsialis SA
published in: American journal of respiratory cell and molecular biology
information resource reference: The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2006-09-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of haem oxygenase-1 in microbial host defence.
PubMed Identifier: 19016784
author list: Chung SW, Hall SR, Perrella MA
published in: Cellular microbiology
information resource reference: Role of haem oxygenase-1 in microbial host defence. Cell Microbiol. 2009 Feb; 11(2):199-207.
journal title abbreviation: Cell Microbiol
publication date: 2008-11-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.
PubMed Identifier: 19097991
author list: Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA
published in: American journal of respiratory cell and molecular biology
information resource reference: High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2008-12-18T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.
PubMed Identifier: 7738192
author list: Yoshizumi M, Lee WS, Hsieh CM, Tsai JC, Li J, Perrella MA, Patterson C, Endege WO, Schlegel R, Lee ME
published in: The Journal of clinical investigation
information resource reference: Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. J Clin Invest. 1995 May; 95(5):2275-80.
journal title abbreviation: J Clin Invest
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.
PubMed Identifier: 8631978
author list: Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perrella MA, Cooke C, Wang H, Haber E, Schlegel R, Lee ME
published in: The Journal of biological chemistry
information resource reference: Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16; 271(7):3667-70.
journal title abbreviation: J Biol Chem
publication date: 1996-02-16T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Transforming growth factor-ß1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2.
PubMed Identifier: 21437904
author list: Chung SW, Kwon MY, Kang YH, Chung HT, Lee SJ, Kim HP, Perrella MA
published in: Journal of cellular physiology
information resource reference: Transforming growth factor-ß1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2. J Cell Physiol. 2012 Jan; 227(1):351-60.
journal title abbreviation: J Cell Physiol
publication date: 2012-01-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury.
PubMed Identifier: 21903945
author list: Kwon MY, Liu X, Lee SJ, Kang YH, Choi AM, Lee KU, Perrella MA, Chung SW
published in: Arteriosclerosis, thrombosis, and vascular biology
information resource reference: Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2441-7.
journal title abbreviation: Arterioscler Thromb Vasc Biol
publication date: 2011-11-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148.
PubMed Identifier: 28886261
author list: Tsoyi K, Chu SG, Patino-Jaramillo NG, Wilder J, Villalba J, Doyle-Eisele M, McDonald J, Liu X, El-Chemaly S, Perrella MA, Rosas IO
published in: American journal of respiratory cell and molecular biology
information resource reference: Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148. Am J Respir Cell Mol Biol. 2018 02; 58(2):208-215.
journal title abbreviation: Am J Respir Cell Mol Biol
publication date: 2018-02-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
PubMed Identifier: 21967897
author list: Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67.
journal title abbreviation: J Immunol
publication date: 2011-10-03T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells.
PubMed Identifier: 7814392
author list: Li J, Perrella MA, Tsai JC, Yet SF, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME
published in: The Journal of biological chemistry
information resource reference: Induction of vascular endothelial growth factor gene expression by interleukin-1 beta in rat aortic smooth muscle cells. J Biol Chem. 1995 Jan 06; 270(1):308-12.
journal title abbreviation: J Biol Chem
publication date: 1995-01-06T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/882070
PubMed Identifier: 8662809
author list: Perrella MA, Patterson C, Tan L, Yet SF, Hsieh CM, Yoshizumi M, Lee ME
published in: The Journal of biological chemistry
information resource reference: Suppression of interleukin-1beta-induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells. Evidence for mechanisms other than NF-kappaB. J Biol Chem. 1996 Jun 07; 271(23):13776-80.
journal title abbreviation: J Biol Chem
publication date: 1996-06-07T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Suppression of interleukin-1beta-induced nitric-oxide synthase promoter/enhancer activity by transforming growth factor-beta1 in vascular smooth muscle cells. Evidence for mechanisms other than NF-kappaB.

Role of TGF-beta in vascular development and vascular reactivity.
PubMed Identifier: 9525696
author list: Perrella MA, Jain MK, Lee ME
published in: Mineral and electrolyte metabolism
information resource reference: Role of TGF-beta in vascular development and vascular reactivity. Miner Electrolyte Metab. 1998; 24(2-3):136-43.
journal title abbreviation: Miner Electrolyte Metab
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat.
PubMed Identifier: 10864912
author list: Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S
published in: Circulation research
information resource reference: Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9.
journal title abbreviation: Circ Res
publication date: 2000-06-23T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3.
PubMed Identifier: 10973958
author list: Werner F, Jain MK, Feinberg MW, Sibinga NE, Pellacani A, Wiesel P, Chin MT, Topper JN, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem. 2000 Nov 24; 275(47):36653-8.
journal title abbreviation: J Biol Chem
publication date: 2000-11-24T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.
PubMed Identifier: 15066951
author list: Kong D, Melo LG, Mangi AA, Zhang L, Lopez-Ilasaca M, Perrella MA, Liew CC, Pratt RE, Dzau VJ
published in: Circulation
information resource reference: Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation. 2004 Apr 13; 109(14):1769-75.
journal title abbreviation: Circulation
publication date: 2004-04-05T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme oxygenase-1: a novel drug target for atherosclerotic diseases?
PubMed Identifier: 17101869
author list: Stocker R, Perrella MA
published in: Circulation
information resource reference: Heme oxygenase-1: a novel drug target for atherosclerotic diseases? Circulation. 2006 Nov 14; 114(20):2178-89.
journal title abbreviation: Circulation
publication date: 2006-11-14T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.
PubMed Identifier: 23459001
author list: Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK
published in: Genomics
information resource reference: Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics. 2013 May; 101(5):263-72.
journal title abbreviation: Genomics
publication date: 2013-03-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure.
PubMed Identifier: 8342659
author list: Perrella MA, Aarhus LL, Heublein DM, Lewicki JA, Burnett JC
published in: The American journal of physiology
information resource reference: Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure. Am J Physiol. 1993 Jul; 265(1 Pt 2):H401-8.
journal title abbreviation: Am J Physiol
publication date: 1993-07-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer.
PubMed Identifier: 10085153
author list: Perrella MA, Pellacani A, Wiesel P, Chin MT, Foster LC, Ibanez M, Hsieh CM, Reeves R, Yet SF, Lee ME
published in: The Journal of biological chemistry
information resource reference: High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter/enhancer. J Biol Chem. 1999 Mar 26; 274(13):9045-52.
journal title abbreviation: J Biol Chem
publication date: 1999-03-26T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells.
PubMed Identifier: 10657993
author list: Foster LC, Wiesel P, Huggins GS, Pañares R, Chin MT, Pellacani A, Perrella MA
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Role of activating protein-1 and high mobility group-I(Y) protein in the induction of CD44 gene expression by interleukin-1beta in vascular smooth muscle cells. FASEB J. 2000 Feb; 14(2):368-78.
journal title abbreviation: FASEB J
publication date: 2000-02-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.
PubMed Identifier: 11036073
author list: Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P
published in: The Journal of biological chemistry
information resource reference: ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem. 2001 Feb 02; 276(5):3302-9.
journal title abbreviation: J Biol Chem
publication date: 2000-10-17T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular mechanisms of morning onset of myocardial infarction.
PubMed Identifier: 11795300
author list: Maemura K, Layne MD, Watanabe M, Perrell MA, Nagai R, Lee ME
published in: Annals of the New York Academy of Sciences
information resource reference: Molecular mechanisms of morning onset of myocardial infarction. Ann N Y Acad Sci. 2001 Dec; 947:398-402.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2001-12-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
PubMed Identifier: 23447017
author list: Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD
published in: Science translational medicine
information resource reference: Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26.
journal title abbreviation: Sci Transl Med
publication date: 2013-02-27T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
PubMed Identifier: 7559454
author list: Patterson C, Perrella MA, Hsieh CM, Yoshizumi M, Lee ME, Haber E
published in: The Journal of biological chemistry
information resource reference: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem. 1995 Sep 29; 270(39):23111-8.
journal title abbreviation: J Biol Chem
publication date: 1995-09-29T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

75 Francis St
type: Address
address line 1: Brigham and Women's Hospital
address line 2: Pulmonary Medicine
address line 3: 75 Francis St
city: Boston
postal code: 02115
state or province: MA

Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.
PubMed Identifier: 22140090
author list: Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK
published in: Human molecular genetics
information resource reference: Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
journal title abbreviation: Hum Mol Genet
publication date: 2011-12-02T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasma gelsolin is a marker and therapeutic agent in animal sepsis.
PubMed Identifier: 17205019
author list: Lee PS, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP
published in: Critical care medicine
information resource reference: Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Crit Care Med. 2007 Mar; 35(3):849-55.
journal title abbreviation: Crit Care Med
publication date: 2007-03-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.
PubMed Identifier: 18060048
author list: Chung SW, Liu X, Macias AA, Baron RM, Perrella MA
published in: The Journal of clinical investigation
information resource reference: Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest. 2008 Jan; 118(1):239-47.
journal title abbreviation: J Clin Invest
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells.
PubMed Identifier: 7760822
author list: Yoshizumi M, Hsieh CM, Zhou F, Tsai JC, Patterson C, Perrella MA, Lee ME
published in: Molecular and cellular biology
information resource reference: The ATF site mediates downregulation of the cyclin A gene during contact inhibition in vascular endothelial cells. Mol Cell Biol. 1995 Jun; 15(6):3266-72.
journal title abbreviation: Mol Cell Biol
publication date: 1995-06-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury.
PubMed Identifier: 8663449
author list: Hsieh CM, Yoshizumi M, Endege WO, Kho CJ, Jain MK, Kashiki S, de los Santos R, Lee WS, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996 Jul 19; 271(29):17354-9.
journal title abbreviation: J Biol Chem
publication date: 1996-07-19T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for human lung stem cells.
PubMed Identifier: 21561345
author list: Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P
published in: The New England journal of medicine
information resource reference: Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806.
journal title abbreviation: N Engl J Med
publication date: 2011-05-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1038446
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Mesenchymal Stromal Cell Therapy: Does the Source Matter?

Mesenchymal Stromal Cell Therapy: Does the Source Matter?
PubMed Identifier: 29337802
author list: Ghanta S, Kwon MY, Rosas IO, Liu X, Perrella MA
published in: Critical care medicine
information resource reference: Mesenchymal Stromal Cell Therapy: Does the Source Matter? Crit Care Med. 2018 02; 46(2):343-345.
journal title abbreviation: Crit Care Med
publication date: 2018-02-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition.
PubMed Identifier: 8456954
author list: Haas JA, Khraibi AA, Perrella MA, Knox FG
published in: The American journal of physiology
information resource reference: Role of renal interstitial hydrostatic pressure in natriuresis of systemic nitric oxide inhibition. Am J Physiol. 1993 Mar; 264(3 Pt 2):F411-4.
journal title abbreviation: Am J Physiol
publication date: 1993-03-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1041956
type: Authorship
author rank in publication: 10
linked author: Perrella, Mark
linked information resource: Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148.

Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.
PubMed Identifier: 9624159
author list: Layne MD, Endege WO, Jain MK, Yet SF, Hsieh CM, Chin MT, Perrella MA, Blanar MA, Haber E, Lee ME
published in: The Journal of biological chemistry
information resource reference: Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation. J Biol Chem. 1998 Jun 19; 273(25):15654-60.
journal title abbreviation: J Biol Chem
publication date: 1998-06-19T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells.
PubMed Identifier: 9685385
author list: Foster LC, Arkonac BM, Sibinga NE, Shi C, Perrella MA, Haber E
published in: The Journal of biological chemistry
information resource reference: Regulation of CD44 gene expression by the proinflammatory cytokine interleukin-1beta in vascular smooth muscle cells. J Biol Chem. 1998 Aug 07; 273(32):20341-6.
journal title abbreviation: J Biol Chem
publication date: 1998-08-07T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Cardiac atrial natriuretic factor during evolution of congestive heart failure.
PubMed Identifier: 1373574
author list: Perrella MA, Schwab TR, O'Murchu B, Redfield MM, Wei CM, Edwards BS, Burnett JC
published in: The American journal of physiology
information resource reference: Cardiac atrial natriuretic factor during evolution of congestive heart failure. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1248-55.
journal title abbreviation: Am J Physiol
publication date: 1992-04-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure.
PubMed Identifier: 1658047
author list: Margulies KB, Perrella MA, McKinley LJ, Burnett JC
published in: The Journal of clinical investigation
information resource reference: Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure. J Clin Invest. 1991 Nov; 88(5):1636-42.
journal title abbreviation: J Clin Invest
publication date: 1991-11-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Heme oxygenase 1 in regulation of inflammation and oxidative damage.
PubMed Identifier: 12078492
author list: Yet SF, Melo LG, Layne MD, Perrella MA
published in: Methods in enzymology
information resource reference: Heme oxygenase 1 in regulation of inflammation and oxidative damage. Methods Enzymol. 2002; 353:163-76.
journal title abbreviation: Methods Enzymol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 100646
type: Authorship
author rank in publication: 5
linked author: Perrella, Mark
linked information resource: Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.

Role of HO-1 in renoprotection: location, location, location.
PubMed Identifier: 15086942
author list: Chung SW, Perrella MA
published in: Kidney international
information resource reference: Role of HO-1 in renoprotection: location, location, location. Kidney Int. 2004 May; 65(5):1968-9.
journal title abbreviation: Kidney Int
publication date: 2004-05-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice.
PubMed Identifier: 9553112
author list: Yet SF, Folta SC, Jain MK, Hsieh CM, Maemura K, Layne MD, Zhang D, Marria PB, Yoshizumi M, Chin MT, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Molecular cloning, characterization, and promoter analysis of the mouse Crp2/SmLim gene. Preferential expression of its promoter in the vascular smooth muscle cells of transgenic mice. J Biol Chem. 1998 Apr 24; 273(17):10530-7.
journal title abbreviation: J Biol Chem
publication date: 1998-04-24T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif.
PubMed Identifier: 10318857
author list: Hsieh CM, Yet SF, Layne MD, Watanabe M, Hong AM, Perrella MA, Lee ME
published in: The Journal of biological chemistry
information resource reference: Genomic cloning and promoter analysis of aortic preferentially expressed gene-1. Identification of a vascular smooth muscle-specific promoter mediated by an E box motif. J Biol Chem. 1999 May 14; 274(20):14344-51.
journal title abbreviation: J Biol Chem
publication date: 1999-05-14T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene.
PubMed Identifier: 11827926
author list: Melo LG, Agrawal R, Zhang L, Rezvani M, Mangi AA, Ehsan A, Griese DP, Dell'Acqua G, Mann MJ, Oyama J, Yet SF, Layne MD, Perrella MA, Dzau VJ
published in: Circulation
information resource reference: Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation. 2002 Feb 05; 105(5):602-7.
journal title abbreviation: Circulation
publication date: 2002-02-05T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine.
PubMed Identifier: 9312159
author list: Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E, Lee ME
published in: The Journal of biological chemistry
information resource reference: Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem. 1997 Oct 03; 272(40):25380-5.
journal title abbreviation: J Biol Chem
publication date: 1997-10-03T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor.
PubMed Identifier: 1391720
author list: Sandok EK, Lerman A, Stingo AJ, Perrella MA, Gloviczki P, Burnett JC
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Endothelin in a model of acute ischemic renal dysfunction: modulating action of atrial natriuretic factor. J Am Soc Nephrol. 1992 Aug; 3(2):196-202.
journal title abbreviation: J Am Soc Nephrol
publication date: 1992-08-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource