Luscinskas, Francis
completed student projects: Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
eCommons Login: FWL2
first name: Francis
last name: Luscinskas
coauthor of: Lichtman, Andrew
coauthor of: Gimbrone, Michael
coauthor of: Geha, Raif
coauthor of: Croce, Kevin
coauthor of: Sircar, Monica
full name: Francis W. Luscinskas, Ph.D.
has faculty rank: Full Professor
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photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 23488
person in primary position: Professor of Pathology, Emeritus
physical neighbor: Lichtman, Andrew
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similar to: Springer, Timothy
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Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells.
PubMed Identifier: 1539628
author list: Shen J, Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA
published in: The American journal of physiology
information resource reference: Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C384-90.
journal title abbreviation: Am J Physiol
publication date: 1992-02-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.
PubMed Identifier: 11420040
author list: Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN
published in: Immunity
information resource reference: Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun; 14(6):693-704.
journal title abbreviation: Immunity
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/1003496
PubMed Identifier: 11733377
author list: Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW
published in: The American journal of pathology
information resource reference: Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow. Am J Pathol. 2001 Dec; 159(6):2281-91.
journal title abbreviation: Am J Pathol
publication date: 2001-12-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow.

Authorship 10161
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.
PubMed Identifier: 16014561
author list: Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH
published in: Blood
information resource reference: T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005 Nov 15; 106(10):3432-9.
journal title abbreviation: Blood
publication date: 2005-07-12T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
PubMed Identifier: 9128259
author list: Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW
published in: The Journal of cell biology
information resource reference: Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. J Cell Biol. 1997 Apr 21; 137(2):509-19.
journal title abbreviation: J Cell Biol
publication date: 1997-04-21T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro.
PubMed Identifier: 9725249
author list: Lim YC, Snapp K, Kansas GS, Camphausen R, Ding H, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro. J Immunol. 1998 Sep 01; 161(5):2501-8.
journal title abbreviation: J Immunol
publication date: 1998-09-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105672
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells.

ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
PubMed Identifier: 18414683
author list: Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK
published in: The Journal of clinical investigation
information resource reference: ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May; 118(5):1632-44.
journal title abbreviation: J Clin Invest
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium.
PubMed Identifier: 11490021
author list: Shaw SK, Bamba PS, Perkins BN, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol. 2001 Aug 15; 167(4):2323-30.
journal title abbreviation: J Immunol
publication date: 2001-08-15T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of leukocyte transmigration: cell surface interactions and signaling events.
PubMed Identifier: 14688302
author list: Liu Y, Shaw SK, Ma S, Yang L, Luscinskas FW, Parkos CA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol. 2004 Jan 01; 172(1):7-13.
journal title abbreviation: J Immunol
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion.
PubMed Identifier: 3049673
author list: Wheeler ME, Luscinskas FW, Bevilacqua MP, Gimbrone MA
published in: The Journal of clinical investigation
information resource reference: Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. J Clin Invest. 1988 Oct; 82(4):1211-8.
journal title abbreviation: J Clin Invest
publication date: 1988-10-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells.
PubMed Identifier: 7542999
author list: Kiely JM, Cybulsky MI, Luscinskas FW, Gimbrone MA
published in: Arteriosclerosis, thrombosis, and vascular biology
information resource reference: Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1995 Aug; 15(8):1211-8.
journal title abbreviation: Arterioscler Thromb Vasc Biol
publication date: 1995-08-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

CD99 is a key mediator of the transendothelial migration of neutrophils.
PubMed Identifier: 17202377
author list: Lou O, Alcaide P, Luscinskas FW, Muller WA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: CD99 is a key mediator of the transendothelial migration of neutrophils. J Immunol. 2007 Jan 15; 178(2):1136-43.
journal title abbreviation: J Immunol
publication date: 2007-01-15T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
PubMed Identifier: 16574902
author list: Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK
published in: Circulation research
information resource reference: Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res. 2006 May 12; 98(9):1134-40.
journal title abbreviation: Circ Res
publication date: 2006-03-30T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.
PubMed Identifier: 2162850
author list: Nigam S, Fiore S, Luscinskas FW, Serhan CN
published in: Journal of cellular physiology
information resource reference: Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23.
journal title abbreviation: J Cell Physiol
publication date: 1990-06-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
PubMed Identifier: 11929779
author list: Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW
published in: Blood
information resource reference: Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6.
journal title abbreviation: Blood
publication date: 2002-04-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105460
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.

Authorship 1078159
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G.

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G.
PubMed Identifier: 29976772
author list: Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G, Luscinskas FW, Libby P
published in: Arteriosclerosis, thrombosis, and vascular biology
information resource reference: Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1901-1912.
journal title abbreviation: Arterioscler Thromb Vasc Biol
publication date: 2018-08-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/1063951
PubMed Identifier: 21775704
author list: Williams MR, Luscinskas FW
published in: American journal of physiology. Cell physiology
information resource reference: Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1". Am J Physiol Cell Physiol. 2011 Oct; 301(4):C777-9.
journal title abbreviation: Am J Physiol Cell Physiol
publication date: 2011-07-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1".

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.
PubMed Identifier: 2564407
author list: Luscinskas FW, Brock AF, Arnaout MA, Gimbrone MA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 01; 142(7):2257-63.
journal title abbreviation: J Immunol
publication date: 1989-04-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling.
PubMed Identifier: 7504019
author list: Ley K, Baker JB, Cybulsky MI, Gimbrone MA, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J Immunol. 1993 Dec 01; 151(11):6347-57.
journal title abbreviation: J Immunol
publication date: 1993-12-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105128
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1.

Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.
PubMed Identifier: 21264293
author list: Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP
published in: PloS one
information resource reference: Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One. 2011 Jan 14; 6(1):e14525.
journal title abbreviation: PLoS One
publication date: 2011-01-14T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow.
PubMed Identifier: 8494987
author list: Shen J, Gimbrone MA, Luscinskas FW, Dewey CF
published in: Biophysical journal
information resource reference: Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow. Biophys J. 1993 Apr; 64(4):1323-30.
journal title abbreviation: Biophys J
publication date: 1993-04-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
PubMed Identifier: 20805498
author list: Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-08-30T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells.
PubMed Identifier: 16894036
author list: Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM
published in: Circulation
information resource reference: Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7.
journal title abbreviation: Circulation
publication date: 2006-08-07T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 106978
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling.

Authorship 110287
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.

Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells.
PubMed Identifier: 10359580
author list: Xie H, Lim YC, Luscinskas FW, Lichtman AH
published in: The Journal of experimental medicine
information resource reference: Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. J Exp Med. 1999 Jun 07; 189(11):1765-76.
journal title abbreviation: J Exp Med
publication date: 1999-06-07T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow.
PubMed Identifier: 7532680
author list: Luscinskas FW, Ding H, Lichtman AH
published in: The Journal of experimental medicine
information resource reference: P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow. J Exp Med. 1995 Mar 01; 181(3):1179-86.
journal title abbreviation: J Exp Med
publication date: 1995-03-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.
PubMed Identifier: 16709814
author list: Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 2006 Jun 01; 176(11):6568-75.
journal title abbreviation: J Immunol
publication date: 2006-06-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.
PubMed Identifier: 7515891
author list: Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA
published in: The Journal of cell biology
information resource reference: Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol. 1994 Jun; 125(6):1417-27.
journal title abbreviation: J Cell Biol
publication date: 1994-06-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.
PubMed Identifier: 17702895
author list: Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN
published in: Blood
information resource reference: Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood. 2007 Nov 15; 110(10):3682-90.
journal title abbreviation: Blood
publication date: 2007-08-16T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.
PubMed Identifier: 21873519
author list: Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J Immunol. 2011 Oct 01; 187(7):3521-9.
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Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection.
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author list: Newburger PE, Luscinskas FW, Ryan T, Beard CJ, Wright J, Platt OS, Simons ER, Tauber AI
published in: Blood
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Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides.
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author list: Shen J, Luscinskas FW, Gimbrone MA, Dewey CF
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides. Microcirculation. 1994 Apr; 1(1):67-78.
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Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.
PubMed Identifier: 1375271
author list: Spertini O, Luscinskas FW, Gimbrone MA, Tedder TF
published in: The Journal of experimental medicine
information resource reference: Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med. 1992 Jun 01; 175(6):1789-92.
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Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand.
PubMed Identifier: 10225975
author list: Montoya MC, Holtmann K, Snapp KR, Borges E, Sánchez-Madrid F, Luscinskas FW, Kansas G, Vestweber D, de Landázuri MO
published in: The Journal of clinical investigation
information resource reference: Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand. J Clin Invest. 1999 May; 103(9):1317-27.
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p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.
PubMed Identifier: 22648953
author list: Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW
published in: American journal of physiology. Cell physiology
information resource reference: p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C385-95.
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L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.
PubMed Identifier: 8683134
author list: Luscinskas FW, Ding H, Tan P, Cumming D, Tedder TF, Gerritsen ME
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information resource reference: L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. J Immunol. 1996 Jul 01; 157(1):326-35.
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Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.
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linked information resource: Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.

Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.
PubMed Identifier: 31337788
author list: Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW
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information resource reference: Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Sci Rep. 2019 07 23; 9(1):10608.
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Authorship 1179019
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linked information resource: Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas.

Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas.
PubMed Identifier: 31383641
author list: Jain S, Van Scoyk A, Morgan EA, Matthews A, Stevenson K, Newton G, Powers F, Autio A, Louissaint A, Pontini G, Aster JC, Luscinskas FW, Weinstock DM
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information resource reference: Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas. Blood. 2019 10 24; 134(17):1430-1440.
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linked information resource: Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

Authorship 131413
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linked information resource: The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression.

Authorship 172535
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linked information resource: Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent.

Authorship 157792
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linked information resource: Signaling lymphocyte activation molecule regulates development of colitis in mice.

Authorship 13194
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linked information resource: Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection.

Authorship 177604
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linked information resource: The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.

Authorship 1887
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linked information resource: A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism.

Authorship 199875
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linked information resource: p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.

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linked information resource: Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus.

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linked information resource: Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo.

Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo.
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linked information resource: DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.

DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.
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linked information resource: KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.

BCMP
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Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways.
PubMed Identifier: 33285511
author list: Chakraborty A, Staudinger C, King SL, Erickson FC, Lau LS, Bernasconi A, Luscinskas FW, Perlyn C, Dimitroff CJ
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Eosinophils improve cardiac function after myocardial infarction.
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linked information resource: Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins.

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linked information resource: Endothelial STING controls T cell transmigration in an IFNI-dependent manner.

Endothelial STING controls T cell transmigration in an IFNI-dependent manner.
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linked information resource: CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE.

CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE.
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information resource reference: CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE. JCI Insight. 2021 11 08; 6(21).
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linked information resource: Leukocyte-endothelial monolayer adhesion assay (static conditions).

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linked information resource: Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.

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linked information resource: SIRPa - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.

SIRPa - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
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linked information resource: Emerging mechanisms of neutrophil recruitment across endothelium.

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linked information resource: Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

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linked information resource: Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.

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Authorship 24777
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linked information resource: Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.

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linked information resource: Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.

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linked author: Luscinskas, Francis
linked information resource: Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.

Authorship 97729
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.

Authorship 675863
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Functional vascular endothelium derived from human induced pluripotent stem cells.

Functional vascular endothelium derived from human induced pluripotent stem cells.
PubMed Identifier: 24052946
author list: Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G
published in: Stem cell reports
information resource reference: Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13.
journal title abbreviation: Stem Cell Reports
publication date: 2013-07-25T00:00:00
year: 2013
type: Academic Article
type: Article
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type: Information Resource

Authorship 680380
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration.

Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration.
PubMed Identifier: 23990210
author list: Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW
published in: Arteriosclerosis, thrombosis, and vascular biology
information resource reference: Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2566-76.
journal title abbreviation: Arterioscler Thromb Vasc Biol
publication date: 2013-08-29T00:00:00
year: 2013
type: Academic Article
type: Article
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type: Information Resource

Authorship 687939
type: Authorship
author rank in publication: 12
linked author: Luscinskas, Francis
linked information resource: CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.
PubMed Identifier: 24006483
author list: Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW
published in: Molecular biology of the cell
information resource reference: CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions. Mol Biol Cell. 2013 Nov; 24(21):3358-68.
journal title abbreviation: Mol Biol Cell
publication date: 2013-09-04T00:00:00
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type: Academic Article
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Professor of Pathology, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology, Emeritus
position in organization: Harvard Medical School

Authorship 694799
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: CXCL1 excess stops neutrophils in their tracks.

CXCL1 excess stops neutrophils in their tracks.
PubMed Identifier: 24288409
author list: Luscinskas FW
published in: Blood
information resource reference: CXCL1 excess stops neutrophils in their tracks. Blood. 2013 Nov 28; 122(23):3708-10.
journal title abbreviation: Blood
publication date: 2013-11-28T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 698095
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus.

Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus.
PubMed Identifier: 24352318
author list: Luscinskas FW
published in: Nature immunology
information resource reference: Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus. Nat Immunol. 2014 Jan; 15(1):10-1.
journal title abbreviation: Nat Immunol
publication date: 2014-01-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 226171
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Authorship 235978
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.

Authorship 253306
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.

Authorship 289272
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1003496

Authorship 306439
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Emerging topics in the regulation of leukocyte transendothelial migration.

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Authorship 32829
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.

Authorship 724732
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics.

Authorship 720179
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies.

Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies.
PubMed Identifier: 24562377
author list: Leick M, Azcutia V, Newton G, Luscinskas FW
published in: Cell and tissue research
information resource reference: Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies. Cell Tissue Res. 2014 Mar; 355(3):647-56.
journal title abbreviation: Cell Tissue Res
publication date: 2014-02-23T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics.
PubMed Identifier: 24715029
author list: Luscinskas FW, Imhof BA
published in: Seminars in immunopathology
information resource reference: Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics. Semin Immunopathol. 2014 Mar; 36(2):133-6.
journal title abbreviation: Semin Immunopathol
publication date: 2014-04-09T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology
position in organization: Brigham and Women's Hospital

Authorship 274237
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: EWI-2 modulates lymphocyte integrin alpha4beta1 functions.

Authorship 305728
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Early response of endothelial cells to flow is mediated by VE-cadherin.

Authorship 280955
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Leukocyte transendothelial migration: a junctional affair.

Member of the Faculty of Medicine
is primary position: true
position in department: Medicine
position in division: Experimental Medicine Unit - CCIB
sort order: 1
type: Position
HR job title: Member of the Faculty of Medicine
position in organization: Massachusetts General Hospital

Colonna, Marco
first name: Marco
last name: Colonna
full name: Marco Colonna, M.D.
has faculty rank: Other Faculty
Person ID: 227720
person in primary position: Member of the Faculty of Medicine
type: Agent
type: Person
preferred title: Member of the Faculty of Medicine

Neuroimmunology
type: Division
type: Organization

Robert L. Kroc Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Robert L. Kroc Professor of Neurology
position in organization: Brigham and Women's Hospital

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Brigham and Women's Hospital

Latham Family Professor of Biological Chemistry and Molecular Pharmacology
is primary position: true
position in department: BCMP
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Latham Family Professor of Biological Chemistry and Molecular Pharmacology
position in organization: Boston Children's Hospital

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Renal
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Brigham and Women's Hospital

James L. Gamble Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Immunology
sort order: 1
type: Position
HR job title: James L. Gamble Professor of Pediatrics
position in organization: Boston Children's Hospital

Authorship 327338
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.

Authorship 551122
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells.

NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis.
PubMed Identifier: 25263595
author list: Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J
published in: Molecular cell
information resource reference: NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014 Oct 23; 56(2):219-231.
journal title abbreviation: Mol Cell
publication date: 2014-09-25T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 364888
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro.

Authorship 396495
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.

Authorship 409318
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells.

Authorship 436143
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow.

Authorship 765404
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.

Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.
PubMed Identifier: 25246631
author list: Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS
published in: Molecular and cellular biology
information resource reference: Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54.
journal title abbreviation: Mol Cell Biol
publication date: 2014-09-22T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 80356
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.

Authorship 89785
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium.

Authorship 767635
type: Authorship
author rank in publication: 13
linked author: Luscinskas, Francis
linked information resource: NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis.

Authorship 477297
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: CD99 is a key mediator of the transendothelial migration of neutrophils.

Authorship 541053
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Immunology of atherosclerosis: the promise of mouse models.

Authorship 557642
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

Authorship 558924
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions.

Authorship 384434
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.

Authorship 42597
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand.

Authorship 264847
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro.

Authorship 456258
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo.

A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force.
PubMed Identifier: 25772353
author list: Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN
published in: Cell reports
information resource reference: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep. 2015 Mar 17; 10(10):1655-1664.
journal title abbreviation: Cell Rep
publication date: 2015-03-12T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 484276
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: Activation-dependent isolation and culture of murine pulmonary microvascular endothelium.

Authorship 487284
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.

Authorship 319438
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Isolation and culture of murine heart and lung endothelial cells for in vitro model systems.

Authorship 292156
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.

Authorship 470139
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils.

Authorship 218451
type: Authorship
author rank in publication: 13
linked author: Luscinskas, Francis
linked information resource: ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

Authorship 259999
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.

Authorship 296654
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.

Authorship 310079
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.

Authorship 34709
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.

Authorship 343353
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Authorship 121683
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Regulation of leukocyte transmigration: cell surface interactions and signaling events.

Authorship 344181
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow.

Authorship 434946
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.

Authorship 438965
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro.

Authorship 443276
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: FAK and PAX-illin get involved in leukocyte diapedesis.

Authorship 334242
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.

Authorship 527447
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: The biology of endothelial cell-cell lateral junctions.

Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8.
PubMed Identifier: 25799045
author list: Wang G, van Driel BJ, Liao G, O'Keeffe MS, Halibozek PJ, Flipse J, Yigit B, Azcutia V, Luscinskas FW, Wang N, Terhorst C
published in: PloS one
information resource reference: Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS One. 2015; 10(3):e0121968.
journal title abbreviation: PLoS One
publication date: 2015-03-23T00:00:00
year: 2015
type: Academic Article
type: Article
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type: Information Resource

Authorship 352865
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment.

Authorship 451194
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.

Authorship 801209
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Introduction for the special issue on "Tissue Barriers in Inflammation".

Authorship 796687
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8.

Introduction for the special issue on "Tissue Barriers in Inflammation".
PubMed Identifier: 25927017
author list: Luscinskas FW, Leick M, Newton G, Nusrat A
published in: Tissue barriers
information resource reference: Introduction for the special issue on "Tissue Barriers in Inflammation". Tissue Barriers. 2015; 3(1-2):e1015825.
journal title abbreviation: Tissue Barriers
publication date: 2015-02-25T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 89339
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

Authorship 289766
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

Authorship 348466
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells.

Authorship 296580
type: Authorship
author rank in publication: 10
linked author: Luscinskas, Francis
linked information resource: Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration.

Authorship 54222
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Crawling and INTEGRating apical cues.

Authorship 387570
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.

Authorship 547654
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.

Authorship 30225
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Integrins as dynamic regulators of vascular function.

Authorship 30307
type: Authorship
author rank in publication: 10
linked author: Luscinskas, Francis
linked information resource: Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.

Authorship 33804
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment.

Authorship 504169
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.

Authorship 380924
type: Authorship
author rank in publication: 5
linked author: Luscinskas, Francis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/799098

Authorship 478485
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.

Authorship 418862
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Assays of transendothelial migration in vitro.

Authorship 852751
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.

AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.
PubMed Identifier: 26680259
author list: Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN
published in: Nature communications
information resource reference: AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015 Dec 18; 6:10182.
journal title abbreviation: Nat Commun
publication date: 2015-12-18T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
end date: 2005-09-02T00:00:00
start date: 2005-05-25T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Authorship 180323
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: Difference in Th1 and Th17 lymphocyte adhesion to endothelium.

Authorship 866897
type: Authorship
author rank in publication: 10
linked author: Luscinskas, Francis
linked information resource: Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.

Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
PubMed Identifier: 26831939
author list: Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P
published in: Nature communications
information resource reference: Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363.
journal title abbreviation: Nat Commun
publication date: 2016-02-02T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 83982
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro.

Authorship 406822
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro.

Authorship 459395
type: Authorship
author rank in publication: 11
linked author: Luscinskas, Francis
linked information resource: Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.

Authorship 49700
type: Authorship
author rank in publication: 4
linked author: Luscinskas, Francis
linked information resource: Cell-cell adhesive interactions in an in vitro flow chamber.

Authorship 562682
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion.

Assistant Professor
sort order: 2
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 512610
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

Authorship 514046
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps.

2013 Annual Meeting of the American Society for Investigative Pathology
end date: 2014-03-31
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 2013-04-01
type: Grant
sponsor award id: R13CA177075

ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
end date: 2005-07-31
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 1999-09-30
type: Grant
sponsor award id: R01HL065090

2014 Annual Meeting of the American Society for Investigative Pathology
end date: 2015-04-23
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 2014-04-24
type: Grant
sponsor award id: R13CA186413

Endothelial Regulation of Leukocyte Transmigration
end date: 2011-06-30
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 1996-08-01
type: Grant
sponsor award id: R01HL053993

CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking
end date: 2020-09-30
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 2016-05-01
type: Grant
sponsor award id: R01HL125780

ENDOTHELIAL-DEPENDENT LEUKOCYTE ACTIVATION
end date: 1997-01-31
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 1992-02-01
type: Grant
sponsor award id: R29HL047646

Pathophysiology of the Endothelium
end date: 2015-06-30
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 1984-07-01
type: Grant
sponsor award id: P01HL036028

ACTIVATION MECHANISMS IN LEUKOCYTE-ENDOTHELIAL ADHESION
end date: 1900-01-01
principal investigator name: LUSCINSKAS, FRANCIS W.
start date: 1987-11-15
type: Grant
sponsor award id: F32HL007672

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: 2013 Annual Meeting of the American Society for Investigative Pathology

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: 2014 Annual Meeting of the American Society for Investigative Pathology

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: Pathophysiology of the Endothelium

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: ENDOTHELIAL-DEPENDENT LEUKOCYTE ACTIVATION

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: ACTIVATION MECHANISMS IN LEUKOCYTE-ENDOTHELIAL ADHESION

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: Endothelial Regulation of Leukocyte Transmigration

Principal Investigator
type: Researcher Role
researcher role of: Luscinskas, Francis
contributes to: ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES

Authorship 722
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.

Authorship 393876
type: Authorship
author rank in publication: 17
linked author: Luscinskas, Francis
linked information resource: Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.

Authorship 919853
type: Authorship
author rank in publication: 18
linked author: Luscinskas, Francis
linked information resource: A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Authorship 921662
type: Authorship
author rank in publication: 7
linked author: Luscinskas, Francis
linked information resource: A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
PubMed Identifier: 27599296
author list: Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS
published in: The Journal of clinical investigation
information resource reference: A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851.
journal title abbreviation: J Clin Invest
publication date: 2016-09-06T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 52191
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: Neutrophil CD44 rafts and rolls.

Authorship 558124
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides.

Authorship 23526
type: Authorship
author rank in publication: 1
linked author: Luscinskas, Francis
linked information resource: L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.

Authorship 338107
type: Authorship
author rank in publication: 12
linked author: Luscinskas, Francis
linked information resource: Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration.

Authorship 338175
type: Authorship
author rank in publication: 6
linked author: Luscinskas, Francis
linked information resource: Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.

Authorship 942064
type: Authorship
author rank in publication: 12
linked author: Luscinskas, Francis
linked information resource: Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.

Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.
PubMed Identifier: 27965383
author list: Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW
published in: Journal of leukocyte biology
information resource reference: Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017 02; 101(2):493-505.
journal title abbreviation: J Leukoc Biol
publication date: 2016-12-13T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 46649
type: Authorship
author rank in publication: 9
linked author: Luscinskas, Francis
linked information resource: Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration.

Authorship 7259
type: Authorship
author rank in publication: 2
linked author: Luscinskas, Francis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1063951

Authorship 79073
type: Authorship
author rank in publication: 3
linked author: Luscinskas, Francis
linked information resource: Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow.

Iberdrola Visiting Professor
award conferred by: Hospital de la Princesa, Madrid, Spain
start date: 1997
type: Award or Honor Receipt

Excellence in Tutorial Award
award conferred by: Harvard Medical School
start date: 2007
type: Award or Honor Receipt

A.H.A. Established Investigator Award
start date: 2000
type: Award or Honor Receipt

A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism.
PubMed Identifier: 8909255
author list: Goetz DJ, Ding H, Atkinson WJ, Vachino G, Camphausen RT, Cumming DA, Luscinskas FW
published in: The American journal of pathology
information resource reference: A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism. Am J Pathol. 1996 Nov; 149(5):1661-73.
journal title abbreviation: Am J Pathol
publication date: 1996-11-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro.
PubMed Identifier: 8943959
author list: Gerszten RE, Luscinskas FW, Ding HT, Dichek DA, Stoolman LM, Gimbrone MA, Rosenzweig A
published in: Circulation research
information resource reference: Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ Res. 1996 Dec; 79(6):1205-15.
journal title abbreviation: Circ Res
publication date: 1996-12-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro.
PubMed Identifier: 9127000
author list: Allport JR, Ding HT, Ager A, Steeber DA, Tedder TF, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. J Immunol. 1997 May 01; 158(9):4365-72.
journal title abbreviation: J Immunol
publication date: 1997-05-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell-cell adhesive interactions in an in vitro flow chamber.
PubMed Identifier: 10098131
author list: Goetz DJ, Greif DM, Shen J, Luscinskas FW
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Cell-cell adhesive interactions in an in vitro flow chamber. Methods Mol Biol. 1999; 96:137-45.
journal title abbreviation: Methods Mol Biol
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow.
PubMed Identifier: 10901499
author list: Lim YC, Wakelin MW, Henault L, Goetz DJ, Yednock T, Cabañas C, Sánchez-Madrid F, Lichtman AH, Luscinskas FW
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow. Microcirculation. 2000 Jun; 7(3):201-14.
journal title abbreviation: Microcirculation
publication date: 2000-06-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha.
PubMed Identifier: 14530377
author list: Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas FW, Lopez J, Plow E, Simon DI
published in: The Journal of experimental medicine
information resource reference: Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003 Oct 06; 198(7):1077-88.
journal title abbreviation: J Exp Med
publication date: 2003-10-06T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
PubMed Identifier: 15136591
author list: SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK
published in: The Journal of experimental medicine
information resource reference: KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15.
journal title abbreviation: J Exp Med
publication date: 2004-05-10T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Emerging topics in the regulation of leukocyte transendothelial migration.
PubMed Identifier: 15804976
author list: Rao RM, Shaw SK, Kim M, Luscinskas FW
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Emerging topics in the regulation of leukocyte transendothelial migration. Microcirculation. 2005 Jan-Feb; 12(1):83-9.
journal title abbreviation: Microcirculation
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.
PubMed Identifier: 16461842
author list: Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM
published in: Circulation
information resource reference: Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 07; 113(5):691-700.
journal title abbreviation: Circulation
publication date: 2006-02-07T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Isolation and culture of murine heart and lung endothelial cells for in vitro model systems.
PubMed Identifier: 16799196
author list: Lim YC, Luscinskas FW
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Isolation and culture of murine heart and lung endothelial cells for in vitro model systems. Methods Mol Biol. 2006; 341:141-54.
journal title abbreviation: Methods Mol Biol
publication date: 2006-01-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Leukocyte-endothelial monolayer adhesion assay (static conditions).
PubMed Identifier: 10098130
author list: Kiely JM, Luscinskas FW, Gimbrone MA
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Leukocyte-endothelial monolayer adhesion assay (static conditions). Methods Mol Biol. 1999; 96:131-6.
journal title abbreviation: Methods Mol Biol
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions.
PubMed Identifier: 1381398
author list: Luscinskas FW, Kiely JM, Ding H, Obin MS, Hébert CA, Baker JB, Gimbrone MA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions. J Immunol. 1992 Sep 15; 149(6):2163-71.
journal title abbreviation: J Immunol
publication date: 1992-09-15T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Leukocyte transendothelial migration: a junctional affair.
PubMed Identifier: 11978082
author list: Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK
published in: Seminars in immunology
information resource reference: Leukocyte transendothelial migration: a junctional affair. Semin Immunol. 2002 Apr; 14(2):105-13.
journal title abbreviation: Semin Immunol
publication date: 2002-04-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.
PubMed Identifier: 17673684
author list: Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW
published in: Circulation research
information resource reference: Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res. 2007 Aug 03; 101(3):234-47.
journal title abbreviation: Circ Res
publication date: 2007-08-03T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.
PubMed Identifier: 20386708
author list: Azcutia V, Abu-Taha M, Romacho T, Vázquez-Bella M, Matesanz N, Luscinskas FW, Rodríguez-Mañas L, Sanz MJ, Sánchez-Ferrer CF, Peiró C
published in: PloS one
information resource reference: Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo. PLoS One. 2010 Apr 08; 5(4):e10091.
journal title abbreviation: PLoS One
publication date: 2010-04-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of endothelial cell lateral junctions during leukocyte trafficking.
PubMed Identifier: 12234362
author list: Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK
published in: Immunological reviews
information resource reference: The role of endothelial cell lateral junctions during leukocyte trafficking. Immunol Rev. 2002 Aug; 186:57-67.
journal title abbreviation: Immunol Rev
publication date: 2002-08-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
PubMed Identifier: 10227295
author list: Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Luscinskas FW, Rosenzweig A
published in: Nature
information resource reference: MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999 Apr 22; 398(6729):718-23.
journal title abbreviation: Nature
publication date: 1999-04-22T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro.
PubMed Identifier: 11994507
author list: Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D, Luscinskas FW
published in: Journal of leukocyte biology
information resource reference: Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol. 2002 May; 71(5):821-8.
journal title abbreviation: J Leukoc Biol
publication date: 2002-05-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
PubMed Identifier: 15811956
author list: Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW
published in: Blood
information resource reference: ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood. 2005 Jul 15; 106(2):584-92.
journal title abbreviation: Blood
publication date: 2005-04-05T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Wall shear stress: the missing step for T cell transmigration?
PubMed Identifier: 11376329
author list: Luscinskas FW, Lim YC, Lichtman AH
published in: Nature immunology
information resource reference: Wall shear stress: the missing step for T cell transmigration? Nat Immunol. 2001 Jun; 2(6):478-80.
journal title abbreviation: Nat Immunol
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Signaling lymphocyte activation molecule regulates development of colitis in mice.
PubMed Identifier: 22960654
author list: van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C
published in: Gastroenterology
information resource reference: Signaling lymphocyte activation molecule regulates development of colitis in mice. Gastroenterology. 2012 Dec; 143(6):1544-1554.e7.
journal title abbreviation: Gastroenterology
publication date: 2012-09-06T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/799098
PubMed Identifier: 9254650
author list: Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW
published in: The Journal of experimental medicine
information resource reference: Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. J Exp Med. 1997 Aug 18; 186(4):517-27.
journal title abbreviation: J Exp Med
publication date: 1997-08-18T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions.

Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.
PubMed Identifier: 1717567
author list: Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA, Tedder TF
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol. 1991 Oct 15; 147(8):2565-73.
journal title abbreviation: J Immunol
publication date: 1991-10-15T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

EWI-2 modulates lymphocyte integrin alpha4beta1 functions.
PubMed Identifier: 15070678
author list: Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME
published in: Blood
information resource reference: EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9.
journal title abbreviation: Blood
publication date: 2003-12-18T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Early response of endothelial cells to flow is mediated by VE-cadherin.
PubMed Identifier: 18163230
author list: Rabodzey A, Yao Y, Luscinskas FW, Shaw SK, Dewey CF
published in: Cell communication & adhesion
information resource reference: Early response of endothelial cells to flow is mediated by VE-cadherin. Cell Commun Adhes. 2007 Sep-Oct; 14(5):195-209.
journal title abbreviation: Cell Commun Adhes
publication date: 2007-09-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins.
PubMed Identifier: 12355428
author list: Grabie N, Delfs MW, Lim YC, Westrich JR, Luscinskas FW, Lichtman AH
published in: European journal of immunology
information resource reference: Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Eur J Immunol. 2002 Oct; 32(10):2766-72.
journal title abbreviation: Eur J Immunol
publication date: 2002-10-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps.
PubMed Identifier: 18720226
author list: Alcaide P, Auerbach S, Luscinskas FW
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps. Microcirculation. 2009 Jan; 16(1):43-57.
journal title abbreviation: Microcirculation
publication date: 2009-01-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro.
PubMed Identifier: 16385081
author list: Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW
published in: Circulation research
information resource reference: Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res. 2006 Feb 17; 98(3):394-402.
journal title abbreviation: Circ Res
publication date: 2005-12-29T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus.
PubMed Identifier: 16585266
author list: Xie C, Alcaide P, Geisbrecht BV, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T
published in: The Journal of experimental medicine
information resource reference: Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006 Apr 17; 203(4):985-94.
journal title abbreviation: J Exp Med
publication date: 2006-04-03T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.
PubMed Identifier: 11591774
author list: Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J Immunol. 2001 Oct 15; 167(8):4476-84.
journal title abbreviation: J Immunol
publication date: 2001-10-15T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.
PubMed Identifier: 15374886
author list: Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN
published in: Blood
information resource reference: Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 01; 105(5):1950-5.
journal title abbreviation: Blood
publication date: 2004-09-16T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration.
PubMed Identifier: 15611287
author list: Shaw SK, Ma S, Kim MB, Rao RM, Hartman CU, Froio RM, Yang L, Jones T, Liu Y, Nusrat A, Parkos CA, Luscinskas FW
published in: The Journal of experimental medicine
information resource reference: Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med. 2004 Dec 20; 200(12):1571-80.
journal title abbreviation: J Exp Med
publication date: 2004-12-20T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration.
PubMed Identifier: 17056576
author list: Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol. 2006 Nov 01; 177(9):6440-9.
journal title abbreviation: J Immunol
publication date: 2006-11-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.
PubMed Identifier: 10752954
author list: Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP
published in: Investigative ophthalmology & visual science
information resource reference: Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1153-8.
journal title abbreviation: Invest Ophthalmol Vis Sci
publication date: 2000-04-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Integrins as dynamic regulators of vascular function.
PubMed Identifier: 7522194
author list: Luscinskas FW, Lawler J
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Integrins as dynamic regulators of vascular function. FASEB J. 1994 Sep; 8(12):929-38.
journal title abbreviation: FASEB J
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression.
PubMed Identifier: 7538441
author list: Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T
published in: Immunity
information resource reference: The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity. 1995 May; 2(5):493-506.
journal title abbreviation: Immunity
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.
PubMed Identifier: 17296784
author list: Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW
published in: The Journal of experimental medicine
information resource reference: Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med. 2007 Feb 19; 204(2):431-9.
journal title abbreviation: J Exp Med
publication date: 2007-02-12T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Activation-dependent isolation and culture of murine pulmonary microvascular endothelium.
PubMed Identifier: 7497167
author list: Gerritsen ME, Shen CP, McHugh MC, Atkinson WJ, Kiely JM, Milstone DS, Luscinskas FW, Gimbrone MA
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: Activation-dependent isolation and culture of murine pulmonary microvascular endothelium. Microcirculation. 1995 Aug; 2(2):151-63.
journal title abbreviation: Microcirculation
publication date: 1995-08-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
PubMed Identifier: 22927557
author list: Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
published in: European heart journal
information resource reference: Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24.
journal title abbreviation: Eur Heart J
publication date: 2012-08-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.
PubMed Identifier: 23187125
author list: Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H
published in: The Journal of clinical investigation
information resource reference: Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38.
journal title abbreviation: J Clin Invest
publication date: 2012-11-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

FAK and PAX-illin get involved in leukocyte diapedesis.
PubMed Identifier: 22266717
author list: Luscinskas FW
published in: European journal of immunology
information resource reference: FAK and PAX-illin get involved in leukocyte diapedesis. Eur J Immunol. 2012 Feb; 42(2):296-8.
journal title abbreviation: Eur J Immunol
publication date: 2012-02-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1004049
type: Authorship
author rank in publication: 8
linked author: Luscinskas, Francis
linked information resource: Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.

Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.
PubMed Identifier: 28529998
author list: Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD
published in: Science immunology
information resource reference: Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan; 2(7).
journal title abbreviation: Sci Immunol
publication date: 2017-01-20T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/87939
type: Address
address line 1: 111 Allerton Road
city: Milton
postal code: 02186
state or province: MA

Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo.
PubMed Identifier: 7519828
author list: Pizcueta P, Luscinskas FW
published in: The American journal of pathology
information resource reference: Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo. Am J Pathol. 1994 Aug; 145(2):461-9.
journal title abbreviation: Am J Pathol
publication date: 1994-08-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The biology of endothelial cell-cell lateral junctions.
PubMed Identifier: 11498777
author list: Luscinskas FW, Shaw SK
published in: Microcirculation (New York, N.Y. : 1994)
information resource reference: The biology of endothelial cell-cell lateral junctions. Microcirculation. 2001 Jun; 8(3):141-2.
journal title abbreviation: Microcirculation
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
PubMed Identifier: 17200719
author list: Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
published in: The Journal of clinical investigation
information resource reference: Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205.
journal title abbreviation: J Clin Invest
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent.
PubMed Identifier: 17442972
author list: Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87.
journal title abbreviation: J Immunol
publication date: 2007-05-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells.
PubMed Identifier: 9892607
author list: Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF
published in: The Journal of experimental medicine
information resource reference: The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J Exp Med. 1999 Jan 18; 189(2):241-52.
journal title abbreviation: J Exp Med
publication date: 1999-01-18T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.
PubMed Identifier: 22566565
author list: Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol. 2012 Jun 15; 188(12):6287-99.
journal title abbreviation: J Immunol
publication date: 2012-05-07T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment.
PubMed Identifier: 8712792
author list: Luscinskas FW, Gimbrone MA
published in: Annual review of medicine
information resource reference: Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment. Annu Rev Med. 1996; 47:413-21.
journal title abbreviation: Annu Rev Med
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.
PubMed Identifier: 10092770
author list: Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol. 1999 Mar 15; 162(6):3193-201.
journal title abbreviation: J Immunol
publication date: 1999-03-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
PubMed Identifier: 10865849
author list: Luscinskas FW, Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Rosenzweig A
published in: Annals of the New York Academy of Sciences
information resource reference: C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann N Y Acad Sci. 2000 May; 902:288-93.
journal title abbreviation: Ann N Y Acad Sci
publication date: 2000-05-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.
PubMed Identifier: 1709678
author list: Bochner BS, Luscinskas FW, Gimbrone MA, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP
published in: The Journal of experimental medicine
information resource reference: Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med. 1991 Jun 01; 173(6):1553-7.
journal title abbreviation: J Exp Med
publication date: 1991-06-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration.
PubMed Identifier: 15381727
author list: Rao RM, Betz TV, Lamont DJ, Kim MB, Shaw SK, Froio RM, Baleux F, Arenzana-Seisdedos F, Alon R, Luscinskas FW
published in: The Journal of experimental medicine
information resource reference: Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration. J Exp Med. 2004 Sep 20; 200(6):713-24.
journal title abbreviation: J Exp Med
publication date: 2004-09-20T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils.
PubMed Identifier: 2154229
author list: Luscinskas FW, Nicolaou KC, Webber SE, Veale CA, Gimbrone MA, Serhan CN
published in: Biochemical pharmacology
information resource reference: Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol. 1990 Jan 15; 39(2):355-65.
journal title abbreviation: Biochem Pharmacol
publication date: 1990-01-15T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment.
PubMed Identifier: 12707043
author list: Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW
published in: The American journal of pathology
information resource reference: Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601.
journal title abbreviation: Am J Pathol
publication date: 2003-05-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Emerging mechanisms of neutrophil recruitment across endothelium.
PubMed Identifier: 21839681
author list: Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW
published in: Trends in immunology
information resource reference: Emerging mechanisms of neutrophil recruitment across endothelium. Trends Immunol. 2011 Oct; 32(10):461-9.
journal title abbreviation: Trends Immunol
publication date: 2011-08-11T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
PubMed Identifier: 22815286
author list: Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62.
journal title abbreviation: J Immunol
publication date: 2012-07-18T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
PubMed Identifier: 17625065
author list: Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA
published in: Blood
information resource reference: JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood. 2007 Oct 01; 110(7):2545-55.
journal title abbreviation: Blood
publication date: 2007-07-11T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Crawling and INTEGRating apical cues.
PubMed Identifier: 15052260
author list: Alon R, Luscinskas FW
published in: Nature immunology
information resource reference: Crawling and INTEGRating apical cues. Nat Immunol. 2004 Apr; 5(4):351-3.
journal title abbreviation: Nat Immunol
publication date: 2004-04-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.
PubMed Identifier: 8621937
author list: Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol. 1996 May 15; 156(10):3961-9.
journal title abbreviation: J Immunol
publication date: 1996-05-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunology of atherosclerosis: the promise of mouse models.
PubMed Identifier: 8701975
author list: Lichtman AH, Cybulsky M, Luscinskas FW
published in: The American journal of pathology
information resource reference: Immunology of atherosclerosis: the promise of mouse models. Am J Pathol. 1996 Aug; 149(2):351-7.
journal title abbreviation: Am J Pathol
publication date: 1996-08-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
PubMed Identifier: 17392823
author list: Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
published in: The Journal of investigative dermatology
information resource reference: The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007 Aug; 127(8):1964-72.
journal title abbreviation: J Invest Dermatol
publication date: 2007-03-29T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.
PubMed Identifier: 18641366
author list: Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW
published in: Blood
information resource reference: p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 2008 Oct 01; 112(7):2770-9.
journal title abbreviation: Blood
publication date: 2008-07-18T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.
PubMed Identifier: 20065025
author list: Alcaide P, Lim YC, Luscinskas FW, Fresno M
published in: Infection and immunity
information resource reference: Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion. Infect Immun. 2010 Mar; 78(3):1260-8.
journal title abbreviation: Infect Immun
publication date: 2010-01-11T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Assays of transendothelial migration in vitro.
PubMed Identifier: 18772016
author list: Muller WA, Luscinskas FW
published in: Methods in enzymology
information resource reference: Assays of transendothelial migration in vitro. Methods Enzymol. 2008; 443:155-76.
journal title abbreviation: Methods Enzymol
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
PubMed Identifier: 22219321
author list: Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb 01; 188(3):1421-30.
journal title abbreviation: J Immunol
publication date: 2012-01-04T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.
PubMed Identifier: 2212672
author list: Hébert CA, Luscinskas FW, Kiely JM, Luis EA, Darbonne WC, Bennett GL, Liu CC, Obin MS, Gimbrone MA, Baker JB
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol. 1990 Nov 01; 145(9):3033-40.
journal title abbreviation: J Immunol
publication date: 1990-11-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanical forces induced by the transendothelial migration of human neutrophils.
PubMed Identifier: 18390614
author list: Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B
published in: Biophysical journal
information resource reference: Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J. 2008 Aug; 95(3):1428-38.
journal title abbreviation: Biophys J
publication date: 2008-04-04T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.
PubMed Identifier: 18524990
author list: Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW
published in: Blood
information resource reference: Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood. 2008 Aug 15; 112(4):1280-9.
journal title abbreviation: Blood
publication date: 2008-06-04T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Neutrophil CD44 rafts and rolls.
PubMed Identifier: 20651082
author list: Luscinskas FW
published in: Blood
information resource reference: Neutrophil CD44 rafts and rolls. Blood. 2010 Jul 22; 116(3):314-5.
journal title abbreviation: Blood
publication date: 2010-07-22T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow.
PubMed Identifier: 9103426
author list: Lichtman AH, Ding H, Henault L, Vachino G, Camphausen R, Cumming D, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J Immunol. 1997 Apr 15; 158(8):3640-50.
journal title abbreviation: J Immunol
publication date: 1997-04-15T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.
PubMed Identifier: 10629229
author list: Allport JR, Muller WA, Luscinskas FW
published in: The Journal of cell biology
information resource reference: Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J Cell Biol. 2000 Jan 10; 148(1):203-16.
journal title abbreviation: J Cell Biol
publication date: 2000-01-10T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1.
PubMed Identifier: 1721495
author list: Denton MD, Marsden PA, Luscinskas FW, Brenner BM, Brady HR
published in: The American journal of physiology
information resource reference: Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol. 1991 Dec; 261(6 Pt 2):F1071-9.
journal title abbreviation: Am J Physiol
publication date: 1991-12-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.
PubMed Identifier: 1371130
author list: Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K, Newman W, Luscinskas FW, Gimbrone MA, McIntyre BW, Bochner BS
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 1992 02 15; 148(4):1086-92.
journal title abbreviation: J Immunol
publication date: 1992-02-15T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.
PubMed Identifier: 9580553
author list: Gerszten RE, Lim YC, Ding HT, Snapp K, Kansas G, Dichek DA, Cabañas C, Sánchez-Madrid F, Gimbrone MA, Rosenzweig A, Luscinskas FW
published in: Circulation research
information resource reference: Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ Res. 1998 May 04; 82(8):871-8.
journal title abbreviation: Circ Res
publication date: 1998-05-04T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.
PubMed Identifier: 12810688
author list: Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D
published in: The Journal of experimental medicine
information resource reference: Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med. 2003 Jun 16; 197(12):1701-7.
journal title abbreviation: J Exp Med
publication date: 2003-06-16T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource