My interests are in the cell biology of leukocytes and vascular endothelial cells and their adhesive interactions in the context of the pathophysiology of the inflammatory response. Prior to closing my lab in December 2021, my lab employed mouse and human models to understand the molecular mechanisms involved leukocyte recruitment and in regulating vascular permeability, focusing on the role of vascular endothelial expressed adhesion molecules (e.g., ICAM-1 and CD47, and the adherens junction protein, Vascular Endothelial-cadherin (VE-cadherin, cadherin-5). My lab team combined expertise in endothelial cell biochemistry, immunology and live cell fluorescence microscopy techniques with my collaborators, Drs. Kevin Croce, Andrew Lichtman, and Tanya Mayadas from BWH (MGB) and Charles Parkos, Chairman of Pathology, University of Michigan, who have significant expertise in intravital microscopy of the microcirculation and have established several in vivo experimental models and in vitro models of inflammation and vascular permeability. My laboratory was located in the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital (Mass General Brigham).
Shen J, Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA
Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C384-90.
Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells.
Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN
Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun; 14(6):693-704.
Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation.
Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW
Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow. Am J Pathol. 2001 Dec; 159(6):2281-91.
Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow.
Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005 Nov 15; 106(10):3432-9.
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.
Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. J Cell Biol. 1997 Apr 21; 137(2):509-19.
Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
Lim YC, Snapp K, Kansas GS, Camphausen R, Ding H, Luscinskas FW
Journal of immunology (Baltimore, Md. : 1950)
Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro. J Immunol. 1998 Sep 01; 161(5):2501-8.
Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro.
Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May; 118(5):1632-44.
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Shaw SK, Bamba PS, Perkins BN, Luscinskas FW
Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol. 2001 Aug 15; 167(4):2323-30.
Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium.
Liu Y, Shaw SK, Ma S, Yang L, Luscinskas FW, Parkos CA
Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol. 2004 Jan 01; 172(1):7-13.
Regulation of leukocyte transmigration: cell surface interactions and signaling events.
Wheeler ME, Luscinskas FW, Bevilacqua MP, Gimbrone MA
Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. J Clin Invest. 1988 Oct; 82(4):1211-8.
Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion.
Kiely JM, Cybulsky MI, Luscinskas FW, Gimbrone MA
Arteriosclerosis, thrombosis, and vascular biology
Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1995 Aug; 15(8):1211-8.
Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells.
Lou O, Alcaide P, Luscinskas FW, Muller WA
CD99 is a key mediator of the transendothelial migration of neutrophils. J Immunol. 2007 Jan 15; 178(2):1136-43.
CD99 is a key mediator of the transendothelial migration of neutrophils.
Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK
Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res. 2006 May 12; 98(9):1134-40.
Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
Nigam S, Fiore S, Luscinskas FW, Serhan CN
Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23.
Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.
Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW
Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6.
Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G, Luscinskas FW, Libby P
Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1901-1912.
Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G.
American journal of physiology. Cell physiology
Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1". Am J Physiol Cell Physiol. 2011 Oct; 301(4):C777-9.
Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1".
Luscinskas FW, Brock AF, Arnaout MA, Gimbrone MA
Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 01; 142(7):2257-63.
Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.
Ley K, Baker JB, Cybulsky MI, Gimbrone MA, Luscinskas FW
Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J Immunol. 1993 Dec 01; 151(11):6347-57.
Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling.
Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One. 2011 Jan 14; 6(1):e14525.
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.
Shen J, Gimbrone MA, Luscinskas FW, Dewey CF
Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow. Biophys J. 1993 Apr; 64(4):1323-30.
Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow.
Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS
Proceedings of the National Academy of Sciences of the United States of America
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6.
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking.
Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM
Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7.
Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells.
Xie H, Lim YC, Luscinskas FW, Lichtman AH
Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. J Exp Med. 1999 Jun 07; 189(11):1765-76.
Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells.
P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow. J Exp Med. 1995 Mar 01; 181(3):1179-86.
P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow.
Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH
Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 2006 Jun 01; 176(11):6568-75.
Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.
Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol. 1994 Jun; 125(6):1417-27.
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.
Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN
Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood. 2007 Nov 15; 110(10):3682-90.
Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion.
Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N
Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J Immunol. 2011 Oct 01; 187(7):3521-9.
Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment.
Newburger PE, Luscinskas FW, Ryan T, Beard CJ, Wright J, Platt OS, Simons ER, Tauber AI
Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. Blood. 1986 Oct; 68(4):914-9.
Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection.
Shen J, Luscinskas FW, Gimbrone MA, Dewey CF
Microcirculation (New York, N.Y. : 1994)
Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides. Microcirculation. 1994 Apr; 1(1):67-78.
Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides.
Spertini O, Luscinskas FW, Gimbrone MA, Tedder TF
Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med. 1992 Jun 01; 175(6):1789-92.
Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.
Montoya MC, Holtmann K, Snapp KR, Borges E, Sánchez-Madrid F, Luscinskas FW, Kansas G, Vestweber D, de Landázuri MO
Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand. J Clin Invest. 1999 May; 103(9):1317-27.
Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand.
Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW
p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C385-95.
p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.
Luscinskas FW, Ding H, Tan P, Cumming D, Tedder TF, Gerritsen ME
L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. J Immunol. 1996 Jul 01; 157(1):326-35.
L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.
Persis, Cyrus and Marlow B. Harrison Professor of Medicine
Professor of Pathology and Health Sciences and Technology
Latham Family Professor of Biological Chemistry and Molecular Pharmacology
Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37.
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.
Elsie T. Friedman Professor of Pathology
Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Sci Rep. 2019 07 23; 9(1):10608.
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.
Jain S, Van Scoyk A, Morgan EA, Matthews A, Stevenson K, Newton G, Powers F, Autio A, Louissaint A, Pontini G, Aster JC, Luscinskas FW, Weinstock DM
Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas. Blood. 2019 10 24; 134(17):1430-1440.
Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas.
Azcutia V, Kelm M, Luissint AC, Boerner K, Flemming S, Quiros M, Newton G, Nusrat A, Luscinskas FW, Parkos CA
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2021 03; 14(2):331-341.
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo.
Janssen E, Tohme M, Butts J, Giguere S, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 08 06; 5(15).
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers.
Chakraborty A, Staudinger C, King SL, Erickson FC, Lau LS, Bernasconi A, Luscinskas FW, Perlyn C, Dimitroff CJ
Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. J Autoimmun. 2021 02; 117:102575.
Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways.
Liu J, Yang C, Liu T, Deng Z, Fang W, Zhang X, Li J, Huang Q, Liu C, Wang Y, Yang D, Sukhova GK, Lindholt JS, Diederichsen A, Rasmussen LM, Li D, Newton G, Luscinskas FW, Liu L, Libby P, Wang J, Guo J, Shi GP
Eosinophils improve cardiac function after myocardial infarction. Nat Commun. 2020 12 16; 11(1):6396.
Eosinophils improve cardiac function after myocardial infarction.
Anastasiou M, Newton GA, Kaur K, Carrillo-Salinas FJ, Smolgovsky SA, Bayer AL, Ilyukha V, Sharma S, Poltorak A, Luscinskas FW, Alcaide P
Endothelial STING controls T cell transmigration in an IFNI-dependent manner. JCI Insight. 2021 08 09; 6(15).
Endothelial STING controls T cell transmigration in an IFNI-dependent manner.
Wang H, Newton G, Wu L, Lin LL, Miracco AS, Natesan S, Luscinskas FW
CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE. JCI Insight. 2021 11 08; 6(21).
CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE.
Autio A, Wang H, Velázquez F, Newton G, Parkos CA, Engel P, Engelbertsen D, Lichtman AH, Luscinskas FW
SIRPa - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen. PLoS One. 2022; 17(4):e0266566.
SIRPa - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G
Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13.
Functional vascular endothelium derived from human induced pluripotent stem cells.
Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW
Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2566-76.
Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration.
Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW
CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions. Mol Biol Cell. 2013 Nov; 24(21):3358-68.
CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions.
CXCL1 excess stops neutrophils in their tracks. Blood. 2013 Nov 28; 122(23):3708-10.
CXCL1 excess stops neutrophils in their tracks.
Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus. Nat Immunol. 2014 Jan; 15(1):10-1.
Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus.
Leick M, Azcutia V, Newton G, Luscinskas FW
Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies. Cell Tissue Res. 2014 Mar; 355(3):647-56.
Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies.
Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics. Semin Immunopathol. 2014 Mar; 36(2):133-6.
Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics.
Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J
NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014 Oct 23; 56(2):219-231.
NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis.
Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS
Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54.
Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing.
Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN
A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep. 2015 Mar 17; 10(10):1655-1664.
A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force.
Wang G, van Driel BJ, Liao G, O'Keeffe MS, Halibozek PJ, Flipse J, Yigit B, Azcutia V, Luscinskas FW, Wang N, Terhorst C
Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS One. 2015; 10(3):e0121968.
Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8.
Luscinskas FW, Leick M, Newton G, Nusrat A
Introduction for the special issue on "Tissue Barriers in Inflammation". Tissue Barriers. 2015; 3(1-2):e1015825.
Introduction for the special issue on "Tissue Barriers in Inflammation".
Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN
AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015 Dec 18; 6:10182.
AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.
Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363.
Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
2013 Annual Meeting of the American Society for Investigative Pathology
ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
2014 Annual Meeting of the American Society for Investigative Pathology
Endothelial Regulation of Leukocyte Transmigration
CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking
ENDOTHELIAL-DEPENDENT LEUKOCYTE ACTIVATION
ACTIVATION MECHANISMS IN LEUKOCYTE-ENDOTHELIAL ADHESION
Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851.
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017 02; 101(2):493-505.
Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.
Goetz DJ, Ding H, Atkinson WJ, Vachino G, Camphausen RT, Cumming DA, Luscinskas FW
A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism. Am J Pathol. 1996 Nov; 149(5):1661-73.
A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism.
Gerszten RE, Luscinskas FW, Ding HT, Dichek DA, Stoolman LM, Gimbrone MA, Rosenzweig A
Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ Res. 1996 Dec; 79(6):1205-15.
Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro.
Allport JR, Ding HT, Ager A, Steeber DA, Tedder TF, Luscinskas FW
L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. J Immunol. 1997 May 01; 158(9):4365-72.
L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro.
Goetz DJ, Greif DM, Shen J, Luscinskas FW
Methods in molecular biology (Clifton, N.J.)
Cell-cell adhesive interactions in an in vitro flow chamber. Methods Mol Biol. 1999; 96:137-45.
Cell-cell adhesive interactions in an in vitro flow chamber.
Lim YC, Wakelin MW, Henault L, Goetz DJ, Yednock T, Cabañas C, Sánchez-Madrid F, Lichtman AH, Luscinskas FW
Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow. Microcirculation. 2000 Jun; 7(3):201-14.
Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow.
Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas FW, Lopez J, Plow E, Simon DI
Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003 Oct 06; 198(7):1077-88.
Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha.
SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15.
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
Emerging topics in the regulation of leukocyte transendothelial migration. Microcirculation. 2005 Jan-Feb; 12(1):83-9.
Emerging topics in the regulation of leukocyte transendothelial migration.
Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM
Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 07; 113(5):691-700.
Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells.
Isolation and culture of murine heart and lung endothelial cells for in vitro model systems. Methods Mol Biol. 2006; 341:141-54.
Isolation and culture of murine heart and lung endothelial cells for in vitro model systems.
Leukocyte-endothelial monolayer adhesion assay (static conditions). Methods Mol Biol. 1999; 96:131-6.
Leukocyte-endothelial monolayer adhesion assay (static conditions).
Luscinskas FW, Kiely JM, Ding H, Obin MS, Hébert CA, Baker JB, Gimbrone MA
In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions. J Immunol. 1992 Sep 15; 149(6):2163-71.
In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions.
Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK
Leukocyte transendothelial migration: a junctional affair. Semin Immunol. 2002 Apr; 14(2):105-13.
Leukocyte transendothelial migration: a junctional affair.
Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res. 2007 Aug 03; 101(3):234-47.
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall.
Azcutia V, Abu-Taha M, Romacho T, Vázquez-Bella M, Matesanz N, Luscinskas FW, Rodríguez-Mañas L, Sanz MJ, Sánchez-Ferrer CF, Peiró C
Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo. PLoS One. 2010 Apr 08; 5(4):e10091.
Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo.
The role of endothelial cell lateral junctions during leukocyte trafficking. Immunol Rev. 2002 Aug; 186:57-67.
The role of endothelial cell lateral junctions during leukocyte trafficking.
Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Luscinskas FW, Rosenzweig A
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999 Apr 22; 398(6729):718-23.
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D, Luscinskas FW
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol. 2002 May; 71(5):821-8.
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro.
Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood. 2005 Jul 15; 106(2):584-92.
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
Wall shear stress: the missing step for T cell transmigration? Nat Immunol. 2001 Jun; 2(6):478-80.
Wall shear stress: the missing step for T cell transmigration?
van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C
Signaling lymphocyte activation molecule regulates development of colitis in mice. Gastroenterology. 2012 Dec; 143(6):1544-1554.e7.
Signaling lymphocyte activation molecule regulates development of colitis in mice.
Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW
Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. J Exp Med. 1997 Aug 18; 186(4):517-27.
Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions.
Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA, Tedder TF
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol. 1991 Oct 15; 147(8):2565-73.
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.
Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME
EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9.
EWI-2 modulates lymphocyte integrin alpha4beta1 functions.
Rabodzey A, Yao Y, Luscinskas FW, Shaw SK, Dewey CF
Early response of endothelial cells to flow is mediated by VE-cadherin. Cell Commun Adhes. 2007 Sep-Oct; 14(5):195-209.
Early response of endothelial cells to flow is mediated by VE-cadherin.
Grabie N, Delfs MW, Lim YC, Westrich JR, Luscinskas FW, Lichtman AH
Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Eur J Immunol. 2002 Oct; 32(10):2766-72.
Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins.
Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps. Microcirculation. 2009 Jan; 16(1):43-57.
Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps.
Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW
Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res. 2006 Feb 17; 98(3):394-402.
Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro.
Xie C, Alcaide P, Geisbrecht BV, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T
Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006 Apr 17; 203(4):985-94.
Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus.
Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH, Luscinskas FW
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J Immunol. 2001 Oct 15; 167(8):4476-84.
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.
Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 01; 105(5):1950-5.
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.
Shaw SK, Ma S, Kim MB, Rao RM, Hartman CU, Froio RM, Yang L, Jones T, Liu Y, Nusrat A, Parkos CA, Luscinskas FW
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med. 2004 Dec 20; 200(12):1571-80.
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration.
Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM, Luscinskas FW
Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol. 2006 Nov 01; 177(9):6440-9.
Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration.
Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP
Investigative ophthalmology & visual science
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1153-8.
Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Integrins as dynamic regulators of vascular function. FASEB J. 1994 Sep; 8(12):929-38.
Integrins as dynamic regulators of vascular function.
Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity. 1995 May; 2(5):493-506.
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression.
Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med. 2007 Feb 19; 204(2):431-9.
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.
Gerritsen ME, Shen CP, McHugh MC, Atkinson WJ, Kiely JM, Milstone DS, Luscinskas FW, Gimbrone MA
Activation-dependent isolation and culture of murine pulmonary microvascular endothelium. Microcirculation. 1995 Aug; 2(2):151-63.
Activation-dependent isolation and culture of murine pulmonary microvascular endothelium.
Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24.
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion.
Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38.
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.
FAK and PAX-illin get involved in leukocyte diapedesis. Eur J Immunol. 2012 Feb; 42(2):296-8.
FAK and PAX-illin get involved in leukocyte diapedesis.
Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD
Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan; 2(7).
Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis.
Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo. Am J Pathol. 1994 Aug; 145(2):461-9.
Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo.
The biology of endothelial cell-cell lateral junctions. Microcirculation. 2001 Jun; 8(3):141-2.
The biology of endothelial cell-cell lateral junctions.
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205.
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.
Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW
Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87.
Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent.
Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF
The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J Exp Med. 1999 Jan 18; 189(2):241-52.
The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells.
Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH
IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol. 2012 Jun 15; 188(12):6287-99.
IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.
Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment. Annu Rev Med. 1996; 47:413-21.
Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment.
Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol. 1999 Mar 15; 162(6):3193-201.
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.
Luscinskas FW, Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Rosenzweig A
Annals of the New York Academy of Sciences
C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann N Y Acad Sci. 2000 May; 902:288-93.
C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions.
Bochner BS, Luscinskas FW, Gimbrone MA, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med. 1991 Jun 01; 173(6):1553-7.
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.
Rao RM, Betz TV, Lamont DJ, Kim MB, Shaw SK, Froio RM, Baleux F, Arenzana-Seisdedos F, Alon R, Luscinskas FW
Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration. J Exp Med. 2004 Sep 20; 200(6):713-24.
Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration.
Luscinskas FW, Nicolaou KC, Webber SE, Veale CA, Gimbrone MA, Serhan CN
Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol. 1990 Jan 15; 39(2):355-65.
Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils.
Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW
Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601.
Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment.
Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW
Emerging mechanisms of neutrophil recruitment across endothelium. Trends Immunol. 2011 Oct; 32(10):461-9.
Emerging mechanisms of neutrophil recruitment across endothelium.
Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62.
Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.
Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA
JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood. 2007 Oct 01; 110(7):2545-55.
JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
Crawling and INTEGRating apical cues. Nat Immunol. 2004 Apr; 5(4):351-3.
Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T
Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol. 1996 May 15; 156(10):3961-9.
Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.
Immunology of atherosclerosis: the promise of mouse models. Am J Pathol. 1996 Aug; 149(2):351-7.
Immunology of atherosclerosis: the promise of mouse models.
Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW
The Journal of investigative dermatology
The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007 Aug; 127(8):1964-72.
The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 2008 Oct 01; 112(7):2770-9.
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.
Alcaide P, Lim YC, Luscinskas FW, Fresno M
Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion. Infect Immun. 2010 Mar; 78(3):1260-8.
Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.
Assays of transendothelial migration in vitro. Methods Enzymol. 2008; 443:155-76.
Assays of transendothelial migration in vitro.
Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb 01; 188(3):1421-30.
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Hébert CA, Luscinskas FW, Kiely JM, Luis EA, Darbonne WC, Bennett GL, Liu CC, Obin MS, Gimbrone MA, Baker JB
Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol. 1990 Nov 01; 145(9):3033-40.
Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.
Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B
Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J. 2008 Aug; 95(3):1428-38.
Mechanical forces induced by the transendothelial migration of human neutrophils.
Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood. 2008 Aug 15; 112(4):1280-9.
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.
Neutrophil CD44 rafts and rolls. Blood. 2010 Jul 22; 116(3):314-5.
Lichtman AH, Ding H, Henault L, Vachino G, Camphausen R, Cumming D, Luscinskas FW
CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J Immunol. 1997 Apr 15; 158(8):3640-50.
CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow.
Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J Cell Biol. 2000 Jan 10; 148(1):203-16.
Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow.
Denton MD, Marsden PA, Luscinskas FW, Brenner BM, Brady HR
Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol. 1991 Dec; 261(6 Pt 2):F1071-9.
Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1.
Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K, Newman W, Luscinskas FW, Gimbrone MA, McIntyre BW, Bochner BS
IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 1992 02 15; 148(4):1086-92.
IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.
Gerszten RE, Lim YC, Ding HT, Snapp K, Kansas G, Dichek DA, Cabañas C, Sánchez-Madrid F, Gimbrone MA, Rosenzweig A, Luscinskas FW
Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ Res. 1998 May 04; 82(8):871-8.
Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis.
Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D
Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med. 2003 Jun 16; 197(12):1701-7.
Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.