XL51XihongLinXihong Lin, Ph.D.55500Lin, XihongXihong Lin is Professor and Former Chair of the Department of Biostatistics, Coordinating Director of the Program in Quantitative Genomics at the Harvard T. H. Chan School of Public Health, and Professor of the Department of Statistics at the Faculty of Arts and Sciences of Harvard University, and Associate Member of the Broad Institute of MIT and Harvard.
Dr. Lin’s research interests lie in the development and application of scalable statistical and machine learning methods for the analysis of massive and complex genetic and genomic, epidemiological and health data. Some examples of her current research include analytic methods and applications for large scale Whole Genome Sequencing studies, biobanks and Electronic Health Records, techniques and tools for whole genome variant functional annotations, analysis of the interplay of genes and environment, multiple phenotype analysis, polygenic risk prediction and heritability estimation. Additional examples include integrative analysis of different types of data, Mendelian Randomization, causal mediation analysis and causal inference, federated and transferred learning, single cell genomics, analysis of epidemiological and complex observational studies, and analysis of COVID-19 epidemic data. Dr. Lin’s theoretical and computational statistical research includes statistical methods for testing a large number of complex hypotheses, causal inference, statistical and ML methods for large matrices, prediction models using high-dimensional data, federated and transferred learning, cloud-based statistical computing, and mixed models, nonparametric and semiparametric regression, and statistical methods for epidemiological studies.
Dr. Lin’s statistical methodological research has been supported by the MERIT Award (R37) (2007-2015), the Outstanding Investigator Award (OIA) (R35) (2015-2029) from the National Cancer Institute (NCI), the R01 grant from the National Heart, Lung, and Blood Institute. She is the multiple PI of a Predictive Modeling Center of the Impact of Genomic Variation on Function (IGVF) Program of the National Human Genome Research Institute (NHGRI), and the multiple PI of the U19 grant on Integrative Analysis of Lung Cancer Etiology and Risk from NCI. She is also the contact PI of the T32 training grant on interdisciplinary training in statistical genetics and computational biology. She is the former contact PI of the Program Project (P01) on Statistical Informatics in Cancer Research from NCI, and the former contact PI of the Harvard Analysis Center (U19) of the Genome Sequencing Program of the National Human Genome Research Institute.
Dr. Lin was active in the early phase of the COVID-19 pandemic. She is one of the corresponding authors of the JAMA and Nature papers on the analysis of the Wuhan COVID-19 data on transmission, public health intervention and epidemiological characteristics. She is the senior author of the 2021 Journal of the American Statistical Association Discussion paper on modeling COVID transmission dynamics in US. In Spring 2020, Dr. Lin served on the State of Massachusetts COVID-19 Task Force, and testified in the UK Parliament’s Committee of Science and Technology on COVID Responses.
Dr. Lin was elected to the National Academy of Medicine in 2018 and the National Academy of Sciences in 2023. She received the 2002 Mortimer Spiegelman Award from the American Public Health Association, the 2006 Committee of Presidents of Statistical Societies (COPSS) Presidents’ Award, the 2017 COPSS FN David Award, the 2008 Janet L. Norwood Award for Outstanding Achievement of a Woman in Statistics, the 2022 National Institute of Statistical Sciences Jerome Sacks Award for Outstanding Cross-Disciplinary Research, and the 2022 Marvin Zelen Leadership in Statistical Science Award. She is an elected fellow of American Statistical Association (ASA), Institute of Mathematical Statistics, and International Statistical Institute.
Dr. Lin is the former Chair of the Committee of Presidents of Statistical Societies (COPSS) (2010-2012) and a former member of the Committee of Applied and Theoretical Statistics (CATS) of the National Academy of Science. She is the founding chair of the US Biostatistics Department Chair Group, and the founding co-chair of the Young Researcher Workshop of East-North American Region (ENAR) of the International Biometric Society. She co-launched the Section of Statistical Genetics and Genomics of the American Statistical Association and served as a former section chair. She is the former Coordinating Editor of Biometrics and the founding co-editor of Statistics in Biosciences. She has served on a large number of committees of many statistical societies, numerous NIH and NSF review panels, and several National Academies committees.617/432-2914Professor of Biostatisticscatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10457816129619118Wei Y, Liang J, Zhang R, Guo Y, Shen S, Su L, Lin X, Moran S, Helland Å, Bjaanæs MM, Karlsson A, Planck M, Esteller M, Fleischer T, Staaf J, Zhao Y, Chen F, Christiani DCClinical epigeneticsEpigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC. Clin Epigenetics. 2018; 10:41.Clin Epigenetics2018-04-02T00:00:002018Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC.Authorship 1061874729692868Peng C, Cardenas A, Rifas-Shiman SL, Hivert MF, Gold DR, Platts-Mills TA, Lin X, Oken E, Baccarelli AA, Litonjua AA, DeMeo DLClinical epigeneticsEpigenome-wide association study of total serum immunoglobulin E in children: a life course approach. Clin Epigenetics. 2018; 10:55.Clin Epigenetics2018-04-17T00:00:002018Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach.20453000Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DCCarcinogenesisA Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. 2010 Jul; 31(7):1259-63.Carcinogenesis2010-05-07T00:00:002010A Large-scale genetic association study of esophageal adenocarcinoma risk.21494156Laohaudomchok W, Lin X, Herrick RF, Fang SC, Cavallari JM, Christiani DC, Weisskopf MGJournal of occupational and environmental medicineToenail, blood, and urine as biomarkers of manganese exposure. J Occup Environ Med. 2011 May; 53(5):506-10.J Occup Environ Med2011-05-01T00:00:002011Toenail, blood, and urine as biomarkers of manganese exposure.21606320Ter-Minassian M, Wang Z, Asomaning K, Wu MC, Liu CY, Paulus JK, Liu G, Bradbury PA, Zhai R, Su L, Frauenhoffer CS, Hooshmand SM, De Vivo I, Lin X, Christiani DC, Kulke MHCarcinogenesisGenetic associations with sporadic neuroendocrine tumor risk. Carcinogenesis. 2011 Aug; 32(8):1216-22.Carcinogenesis2011-05-23T00:00:002011Genetic associations with sporadic neuroendocrine tumor risk.22306564VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin XAmerican journal of epidemiologyGenetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol. 2012 May 15; 175(10):1013-20.Am J Epidemiol2012-02-03T00:00:002012Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.Authorship 10716862629859855Wang Z, Wei Y, Zhang R, Su L, Gogarten SM, Liu G, Brennan P, Field JK, McKay JD, Lissowska J, Swiatkowska B, Janout V, Bolca C, Kontic M, Scelo G, Zaridze D, Laurie CC, Doheny KF, Pugh EK, Marosy BA, Hetrick KN, Xiao X, Pikielny C, Hung RJ, Amos CI, Lin X, Christiani DCEBioMedicineMulti-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma. EBioMedicine. 2018 Jun; 32:93-101.EBioMedicine2018-05-31T00:00:002018Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma.21751195Zhai R, Zhao Y, Liu G, Ter-Minassian M, Wu IC, Wang Z, Su L, Asomaning K, Chen F, Kulke MH, Lin X, Heist RS, Wain JC, Christiani DCCancerInteractions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. Cancer. 2012 Feb 01; 118(3):804-11.Cancer2011-07-12T00:00:002011Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study.30001177Brunst KJ, Tignor N, Just A, Liu Z, Lin X, Hacker MR, Bosquet Enlow M, Wright RO, Wang P, Baccarelli AA, Wright RJEpigeneticsCumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort. Epigenetics. 2018; 13(6):665-681.Epigenetics2018-08-15T00:00:002018Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort.21737059Wu MC, Lee S, Cai T, Li Y, Boehnke M, Lin XAmerican journal of human geneticsRare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet. 2011 Jul 15; 89(1):82-93.Am J Hum Genet2011-07-07T00:00:002011Rare-variant association testing for sequencing data with the sequence kernel association test.Authorship 1088208630120420Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DCMolecular psychiatryIdentification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2020 11; 25(11):3010-3019.Mol Psychiatry2018-08-17T00:00:002018Identification of novel loci associated with infant cognitive ability.21281275Cai T, Tonini G, Lin XBiometricsKernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics. 2011 Sep; 67(3):975-86.Biometrics2011-01-31T00:00:002011Kernel machine approach to testing the significance of multiple genetic markers for risk prediction.Authorship 1091178330194655Hu T, Nan B, Lin XLifetime data analysisProportional cross-ratio model. Lifetime Data Anal. 2019 07; 25(3):480-506.Lifetime Data Anal2018-09-07T00:00:002018Proportional cross-ratio model.21532591Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GSNatureAberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 2011 May 26; 473(7348):528-31.Nature2011-05-01T00:00:002011Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.21911369Huang YT, Lin X, Liu Y, Chirieac LR, McGovern R, Wain J, Heist R, Skaug V, Zienolddiny S, Haugen A, Su L, Fox EA, Wong KK, Christiani DCProceedings of the National Academy of Sciences of the United States of AmericaCigarette smoking increases copy number alterations in nonsmall-cell lung cancer. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16345-50.Proc Natl Acad Sci U S A2011-09-12T00:00:002011Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer.23028716Zhao Y, Chen F, Zhai R, Lin X, Diao N, Christiani DCPloS oneAssociation test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS One. 2012; 7(9):e44978.PLoS One2012-09-13T00:00:002012Association test based on SNP set: logistic kernel machine based test vs. principal component analysis.23253229Liu CY, Maity A, Lin X, Wright RO, Christiani DCEnvironmental health : a global access science sourceDesign and analysis issues in gene and environment studies. Environ Health. 2012 Dec 19; 11:93.Environ Health2012-12-19T00:00:002012Design and analysis issues in gene and environment studies.Authorship 1096546330256434Gaynor SM, Schwartz J, Lin XStatistics in medicineMediation analysis for common binary outcomes. Stat Med. 2019 02 20; 38(4):512-529.Stat Med2018-09-06T00:00:002018Mediation analysis for common binary outcomes.26246645Mukherjee R, Pillai NS, Lin XAnnals of statisticsHYPOTHESIS TESTING FOR HIGH-DIMENSIONAL SPARSE BINARY REGRESSION. Ann Stat. 2015 Feb; 43(1):352-381.Ann Stat2015-02-01T00:00:002015HYPOTHESIS TESTING FOR HIGH-DIMENSIONAL SPARSE BINARY REGRESSION.Authorship 11083081830343317Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJIntensive care medicinePlasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Nov; 44(11):1849-1858.Intensive Care Med2018-10-21T00:00:002018Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.30343628Carmona JJ, Barfield RT, Panni T, Nwanaji-Enwerem JC, Just AC, Hutchinson JN, Colicino E, Karrasch S, Wahl S, Kunze S, Jafari N, Zheng Y, Hou L, DeMeo DL, Litonjua AA, Vokonas PS, Peters A, Lin X, Schwartz J, Schulz H, Baccarelli AAEpigeneticsMetastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts. Epigenetics. 2018; 13(10-11):1039-1055.Epigenetics2018-10-21T00:00:002018Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts.30403821Wang H, Cade BE, Sofer T, Sands SA, Chen H, Browning SR, Stilp AM, Louie TL, Thornton TA, Johnson WC, Below JE, Conomos MP, Evans DS, Gharib SA, Guo X, Wood AC, Mei H, Yaffe K, Loredo JS, Ramos AR, Barrett-Connor E, Ancoli-Israel S, Zee PC, Arens R, Shah NA, Taylor KD, Tranah GJ, Stone KL, Hanis CL, Wilson JG, Gottlieb DJ, Patel SR, Rice K, Post WS, Rotter JI, Sunyaev SR, Cai J, Lin X, Purcell SM, Laurie CC, Saxena R, Redline S, Zhu XHuman molecular geneticsAdmixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans. Hum Mol Genet. 2019 02 15; 28(4):675-687.Hum Mol Genet2019-02-15T00:00:002019Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.30412002Huang JV, Cardenas A, Colicino E, Schooling CM, Rifas-Shiman SL, Agha G, Zheng Y, Hou L, Just AC, Litonjua AA, DeMeo DL, Lin X, Oken E, Hivert MF, Baccarelli AAEpigeneticsDNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence. Epigenetics. 2018; 13(10-11):1072-1087.Epigenetics2018-11-13T00:00:002018DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence.18757527Ter-Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, Heist RS, Lynch TJ, Wain JC, Lin X, De Vivo I, Christiani DCCarcinogenesisApoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008 Nov; 29(11):2147-52.Carcinogenesis2008-08-29T00:00:002008Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.23566092Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz JEpigenomicsExposure to airborne particulate matter is associated with methylation pattern in the asthma pathway. Epigenomics. 2013 Apr; 5(2):147-54.Epigenomics2013-04-01T00:00:002013Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway.Authorship 1121782230590456Chen S, Lin XBiostatistics (Oxford, England)Analysis in case-control sequencing association studies with different sequencing depths. Biostatistics. 2020 07 01; 21(3):577-593.Biostatistics2020-07-01T00:00:002020Analysis in case-control sequencing association studies with different sequencing depths.30639324Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR, Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin XAmerican journal of human geneticsEfficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 02 07; 104(2):260-274.Am J Hum Genet2019-01-10T00:00:002019Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies.19197381Wang Z, Chen F, Zhai R, Zhang L, Su L, Lin X, Thompson T, Christiani DCPloS onePlasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. PLoS One. 2009; 4(2):e4380.PLoS One2009-02-06T00:00:002009Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.21829676Huang YT, Lin X, Chirieac LR, McGovern R, Wain JC, Heist RS, Skaug V, Zienolddiny S, Haugen A, Su L, Christiani DCPloS oneImpact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer. PLoS One. 2011; 6(8):e22961.PLoS One2011-08-02T00:00:002011Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer.30738172Peng C, Cardenas A, Rifas-Shiman SL, Hivert MF, Gold DR, Platts-Mills TA, Lin X, Oken E, Avila L, Celedón JC, Weiss ST, Baccarelli AA, Litonjua AA, DeMeo DLThe Journal of allergy and clinical immunologyEpigenetic age acceleration is associated with allergy and asthma in children in Project Viva. J Allergy Clin Immunol. 2019 06; 143(6):2263-2270.e14.J Allergy Clin Immunol2019-02-06T00:00:002019Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.Authorship 11359394Authorship 1138422630876376Peng C, Van Meel ER, Cardenas A, Rifas-Shiman SL, Sonawane AR, Glass KR, Gold DR, Platts-Mills TA, Lin X, Oken E, Hivert MF, Baccarelli AA, De Jong NW, Felix JF, Jaddoe VW, Duijts L, Litonjua AA, DeMeo DLEpigeneticsEpigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization. Epigenetics. 2019 05; 14(5):445-466.Epigenetics2019-03-28T00:00:002019Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization.30826618Gao X, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AAEnvironment internationalImpacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environ Int. 2019 05; 126:395-405.Environ Int2019-02-28T00:00:002019Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective.30849328Liu Y, Chen S, Li Z, Morrison AC, Boerwinkle E, Lin XAmerican journal of human geneticsACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies. Am J Hum Genet. 2019 03 07; 104(3):410-421.Am J Hum Genet2019-03-07T00:00:002019ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies.30875371Sun R, Hui S, Bader GD, Lin X, Kraft PPLoS geneticsPowerful gene set analysis in GWAS with the Generalized Berk-Jones statistic. PLoS Genet. 2019 03; 15(3):e1007530.PLoS Genet2019-03-15T00:00:002019Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic.D055106Procedures1709121780.253463Genome-Wide Association StudyD008957Concepts & Ideas117934930.461369Models, GeneticD040641Genes & Molecular Sequences60420160.544382Quantitative Trait LociAnalytic & Translational Genetics Unit - ATGUAuthorship 1146825930982610Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin XAmerican journal of human geneticsDynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 05 02; 104(5):802-814.Am J Hum Genet2019-04-12T00:00:002019Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies.30990817Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline SPLoS geneticsAssociations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. PLoS Genet. 2019 04; 15(4):e1007739.PLoS Genet2019-04-16T00:00:002019Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.D056726DisordersProcedures106626940.490649Genetic Association Studies31038702Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AAInternational journal of epidemiologyComparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. Int J Epidemiol. 2019 12 01; 48(6):1958-1971.Int J Epidemiol2019-12-01T00:00:002019Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males.D020641Genes & Molecular Sequences2151155000.246157Polymorphism, Single NucleotideAuthorship 1152009331062858Gaynor SM, Sun R, Lin X, Quackenbush JBioinformatics (Oxford, England)Identification of differentially expressed gene sets using the Generalized Berk-Jones statistic. Bioinformatics. 2019 11 01; 35(22):4568-4576.Bioinformatics2019-11-01T00:00:002019Identification of differentially expressed gene sets using the Generalized Berk-Jones statistic.BiostatisticsEpidemiologyMedicineStatisticsEH - Environmental + Occupational Medicine + EpiSleep MedicineBeth Israel Deaconess Medical CenterBrigham and Women's HospitalFaculty of Arts & SciencesHarvard T.H. Chan School of Public HealthMassachusetts General HospitalDCC5DavidChristianiDavid Christopher Christiani, M.D.42.33570000000000-71.1016999000000014998Christiani, DavidElkan Blout Professor of Environmental Genetics31139831Barfield R, Wang H, Liu Y, Brody JA, Swenson B, Li R, Bartz TM, Sotoodehnia N, Chen YI, Cade BE, Chen H, Patel SR, Zhu X, Gharib SA, Johnson WC, Rotter JI, Saxena R, Purcell S, Lin X, Redline S, Sofer TSleepEpigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations. Sleep. 2019 08 01; 42(8).Sleep2019-08-01T00:00:002019Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations.AB131AndreaBaccarelliAndrea Baccarelli, M.D., Ph.D.42.34434300000000-71.1036980000000068960Baccarelli, AndreaDean of the FacultySR165SusanRedlineSusan Redline, M.D.42.33710500000000-71.1023170000000027634Redline, SusanPeter C. Farrell Professor of Sleep MedicineAH38AlbertHofmanAlbert Hofman, M.D., Ph.D.42.33517680000000-71.1024021000000044340Hofman, AlbertStephen B. Kay Family Professor of Public Health and Clinical EpidemiologyAP92AlkesPriceAlkes Price, Ph.D.42.33546850000000-71.1015102000000029036Price, AlkesProfessor of Statistical GeneticsBEC10BrianCadeBrian E. Cade, Ph.D.96122Cade, BrianAssistant Professor of Medicine11282selected publications5.422660.00416894652research areas8.006420.0197218162coauthor of165.67937.740960similar to31209392Xu M, Yao Y, Chen H, Zhang S, Cao SM, Zhang Z, Luo B, Liu Z, Li Z, Xiang T, He G, Feng QS, Chen LZ, Guo X, Jia WH, Chen MY, Zhang X, Xie SH, Peng R, Chang ET, Pedergnana V, Feng L, Bei JX, Xu RH, Zeng MS, Ye W, Adami HO, Lin X, Zhai W, Zeng YX, Liu JNature geneticsGenome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma. Nat Genet. 2019 07; 51(7):1131-1136.Nat Genet2019-06-17T00:00:002019Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma.MJD21MarkDalyMark Joseph Daly, Ph.D.42.36125700000000-71.0655270000000037049Daly, MarkAssociate Professor of MedicinePLK3PeterKraftPeter Kraft, Ph.D.42.33546850000000-71.101510200000008128Kraft, PeterAdjunct Professor of EpidemiologyAuthorship 1186783231489360Kachouie NN, Lin X, Christiani DC, Schwartzman ACommunications in statistics. Case studies, data analysis and applicationsDetection of Local DNA Copy Number Changes in Lung Cancer Population Analyses Using A Multi-Scale Approach. Commun Stat Case Stud Data Anal Appl. 2015; 1(4):206-216.Commun Stat Case Stud Data Anal Appl2016-07-18T00:00:002016Detection of Local DNA Copy Number Changes in Lung Cancer Population Analyses Using A Multi-Scale Approach.Authorship 1192289231553629Gao X, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AAAmerican journal of respiratory and critical care medicineNonsteroidal Antiinflammatory Drugs Modify the Effect of Short-Term Air Pollution on Lung Function. Am J Respir Crit Care Med. 2020 02 01; 201(3):374-378.Am J Respir Crit Care Med2020-02-01T00:00:002020Nonsteroidal Antiinflammatory Drugs Modify the Effect of Short-Term Air Pollution on Lung Function.31501637Kachouie NN, Lin X, Schwartzman ACommunications in statistics: Simulation and computationFDR control of detected regions by multiscale matched filtering. Commun Stat Simul Comput. 2017; 46(1):127-144.Commun Stat Simul Comput2014-12-23T00:00:002014FDR control of detected regions by multiscale matched filtering.31668705Liang J, Cade BE, He KY, Wang H, Lee J, Sofer T, Williams S, Li R, Chen H, Gottlieb DJ, Evans DS, Guo X, Gharib SA, Hale L, Hillman DR, Lutsey PL, Mukherjee S, Ochs-Balcom HM, Palmer LJ, Rhodes J, Purcell S, Patel SR, Saxena R, Stone KL, Tang W, Tranah GJ, Boerwinkle E, Lin X, Liu Y, Psaty BM, Vasan RS, Cho MH, Manichaikul A, Silverman EK, Barr RG, Rich SS, Rotter JI, Wilson JG, Redline S, Zhu XAmerican journal of human geneticsSequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. 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Commun Biol. 2022 07 28; 5(1):756.Commun Biol2022-07-28T00:00:002022Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.35915169Byun J, Han Y, Li Y, Xia J, Long E, Choi J, Xiao X, Zhu M, Zhou W, Sun R, Bossé Y, Song Z, Schwartz A, Lusk C, Rafnar T, Stefansson K, Zhang T, Zhao W, Pettit RW, Liu Y, Li X, Zhou H, Walsh KM, Gorlov I, Gorlova O, Zhu D, Rosenberg SM, Pinney S, Bailey-Wilson JE, Mandal D, de Andrade M, Gaba C, Willey JC, You M, Anderson M, Wiencke JK, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojeson S, Brenner H, Landi MT, Chanock SJ, Johansson M, Muley T, Risch A, Wichmann HE, Bickeböller H, Christiani DC, Rennert G, Arnold S, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Andrew AS, Kiemeney LA, Shen H, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Patel A, Lan Q, Rothman N, Taylor F, Kachuri L, Witte JS, Sakoda LC, Spitz M, Brennan P, Lin X, McKay J, Hung RJ, Amos CINature geneticsCross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nat Genet. 2022 08; 54(8):1167-1177.Nat Genet2022-08-01T00:00:002022Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Authorship 14650623Authorship 14653833Authorship 14636028935637906Gaynor SM, Fagny M, Lin X, Platig J, Quackenbush JCell reports methodsConnectivity in eQTL networks dictates reproducibility and genomic properties. Cell Rep Methods. 2022 05 23; 2(5):100218.Cell Rep Methods2022-05-23T00:00:002022Connectivity in eQTL networks dictates reproducibility and genomic properties.35845434Li Z, Liu Y, Lin XJournal of the American Statistical AssociationSimultaneous Detection of Signal Regions Using Quadratic Scan Statistics With Applications to Whole Genome Association Studies. J Am Stat Assoc. 2022; 117(538):823-834.J Am Stat Assoc2020-11-12T00:00:002020Simultaneous Detection of Signal Regions Using Quadratic Scan Statistics With Applications to Whole Genome Association Studies.Authorship 150092325Authorship 149115470Authorship 14990501436350676Zhou H, Arapoglou T, Li X, Li Z, Zheng X, Moore J, Asok A, Kumar S, Blue EE, Buyske S, Cox N, Felsenfeld A, Gerstein M, Kenny E, Li B, Matise T, Philippakis A, Rehm HL, Sofia HJ, Snyder G, Weng Z, Neale B, Sunyaev SR, Lin XNucleic acids researchFAVOR: functional annotation of variants online resource and annotator for variation across the human genome. 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Nat Commun. 2022 09 16; 13(1):5437.Nat Commun2022-09-16T00:00:002022Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.36303018Li Z, Li X, Zhou H, Gaynor SM, Selvaraj MS, Arapoglou T, Quick C, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Auer PL, Bielak LF, Bis JC, Blackwell TW, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Conomos MP, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Franceschini N, Freedman BI, Göring HHH, Guo X, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Lin BM, Manichaikul A, Manning AK, Martin LW, Mathias RA, Meigs JB, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O'Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Smith JA, Taylor KD, Taub MA, Vasan RS, Weeks DE, Wilson JG, Yanek LR, Zhao W, Rotter JI, Willer CJ, Natarajan P, Peloso GM, Lin XNature methodsA framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nat Methods. 2022 12; 19(12):1599-1611.Nat Methods2022-10-27T00:00:002022A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.36220816Selvaraj MS, Li X, Li Z, Pampana A, Zhang DY, Park J, Aslibekyan S, Bis JC, Brody JA, Cade BE, Chuang LM, Chung RH, Curran JE, de Las Fuentes L, de Vries PS, Duggirala R, Freedman BI, Graff M, Guo X, Heard-Costa N, Hidalgo B, Hwu CM, Irvin MR, Kelly TN, Kral BG, Lange L, Li X, Lisa M, Lubitz SA, Manichaikul AW, Michael P, Montasser ME, Morrison AC, Naseri T, O'Connell JR, Palmer ND, Peyser PA, Reupena MS, Smith JA, Sun X, Taylor KD, Tracy RP, Tsai MY, Wang Z, Wang Y, Bao W, Wilkins JT, Yanek LR, Zhao W, Arnett DK, Blangero J, Boerwinkle E, Bowden DW, Chen YI, Correa A, Cupples LA, Dutcher SK, Ellinor PT, Fornage M, Gabriel S, Germer S, Gibbs R, He J, Kaplan RC, Kardia SLR, Kim R, Kooperberg C, Loos RJF, Viaud-Martinez KA, Mathias RA, McGarvey ST, Mitchell BD, Nickerson D, North KE, Psaty BM, Redline S, Reiner AP, Vasan RS, Rich SS, Willer C, Rotter JI, Rader DJ, Lin X, Peloso GM, Natarajan PNature communicationsWhole genome sequence analysis of blood lipid levels in >66,000 individuals. Nat Commun. 2022 10 11; 13(1):5995.Nat Commun2022-10-11T00:00:002022Whole genome sequence analysis of blood lipid levels in >66,000 individuals.Authorship 15125426136564505Li X, Quick C, Zhou H, Gaynor SM, Liu Y, Chen H, Selvaraj MS, Sun R, Dey R, Arnett DK, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Correa A, Cupples LA, Curran JE, de Vries PS, Duggirala R, Freedman BI, Göring HHH, Guo X, Haessler J, Kalyani RR, Kooperberg C, Kral BG, Lange LA, Manichaikul A, Martin LW, McGarvey ST, Mitchell BD, Montasser ME, Morrison AC, Naseri T, O'Connell JR, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Reupena MS, Rice KM, Rich SS, Sitlani CM, Smith JA, Taylor KD, Vasan RS, Willer CJ, Wilson JG, Yanek LR, Zhao W, Rotter JI, Natarajan P, Peloso GM, Li Z, Lin XNature geneticsPowerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies. Nat Genet. 2023 01; 55(1):154-164.Nat Genet2022-12-23T00:00:002022Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.36775193Alessi JV, Elkrief A, Ricciuti B, Wang X, Cortellini A, Vaz VR, Lamberti G, Frias RL, Venkatraman D, Fulgenzi CAM, Pecci F, Recondo G, Di Federico A, Barrichello A, Park H, Nishino M, Hambelton GM, Egger JV, Ladanyi M, Digumarthy S, Johnson BE, Christiani DC, Lin X, Gainor JF, Lin JJ, Pinato DJ, Schoenfeld AJ, Awad MMJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerClinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC. J Thorac Oncol. 2023 06; 18(6):731-743.J Thorac Oncol2023-02-10T00:00:002023Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC.37099174Nishino M, Wang X, Ricciuti B, Tseng SC, Park H, Alessi JV, Vaz VR, Hatabu H, Lin X, Christiani DC, Awad MMEuropean radiologyAdvanced non-small-cell lung cancer treated with first-line pembrolizumab plus chemotherapy: tumor response dynamics as a marker for survival. Eur Radiol. 2023 Oct; 33(10):7284-7293.Eur Radiol2023-04-26T00:00:002023Advanced non-small-cell lung cancer treated with first-line pembrolizumab plus chemotherapy: tumor response dynamics as a marker for survival.37247843Alessi JV, Wang X, Elkrief A, Ricciuti B, Li YY, Gupta H, Spurr LF, Rizvi H, Luo J, Pecci F, Lamberti G, Recondo G, Venkatraman D, Di Federico A, Gandhi MM, Vaz VR, Nishino M, Sholl LM, Cherniack AD, Ladanyi M, Price A, Richards AL, Donoghue M, Lindsay J, Sharma B, Turner MM, Pfaff KL, Felt KD, Rodig SJ, Lin X, Meyerson ML, Johnson BE, Christiani DC, Schoenfeld AJ, Awad MMJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerImpact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC. J Thorac Oncol. 2023 11; 18(11):1524-1537.J Thorac Oncol2023-05-27T00:00:002023Impact of Aneuploidy and Chromosome 9p Loss on Tumor Immune Microenvironment and Immune Checkpoint Inhibitor Efficacy in NSCLC.Authorship 154654111Authorship 155581455Authorship 15559083Authorship 15479987Authorship 15442593Authorship 15441849Authorship 15456975Authorship 15440766Authorship 15454106Authorship 156203983Authorship 15440792Authorship 15509225Authorship 15456763Authorship 15455692Authorship 15488609Authorship 154963936Authorship 15712956Authorship 15734913Authorship 15493184Authorship 15444644Authorship 15458374Authorship 154924028Authorship 15449977Authorship 154831619Authorship 15523521Authorship 15503433Authorship 154922228Authorship 15462533Authorship 15441106Authorship 15456596Authorship 154717015Authorship 15464743Authorship 15450217Authorship 15527409Authorship 15489983Authorship 15469685Authorship 15468707Authorship 154701933Authorship 15495625Authorship 154830514Authorship 15445627Authorship 155097297Authorship 15444963Authorship 156840973Authorship 15442102Authorship 15464034Authorship 15440073Authorship 15496943Authorship 15500633Authorship 15442762Authorship 15484955Authorship 15448205Authorship 154511312Authorship 15470727Authorship 157094015Authorship 15541906Authorship 15456113Authorship 15465458Authorship 15650967Authorship 15438022Authorship 15635624Authorship 15444322Authorship 15440593Authorship 15440742Authorship 155294551Authorship 15441487Authorship 155836935Authorship 15458908Authorship 15518469Authorship 15437123Authorship 15448382Authorship 15439153Authorship 15443734Authorship 15453532Authorship 154989838Authorship 15449584Authorship 15461455Authorship 154886848Authorship 154921312Authorship 15456847Authorship 15459203Authorship 156796926Authorship 15471714Authorship 154419525Authorship 154919136Authorship 15460122Authorship 156857424Authorship 15443026Authorship 15452743Authorship 15443483Authorship 15462148Authorship 154677621Authorship 15479448Authorship 15441642Authorship 15488432Authorship 15718053Authorship 15453718Authorship 15527473Authorship 15447932Authorship 15470785Authorship 15448173Authorship 15447833Authorship 157204230Authorship 15441702Authorship 15443274Authorship 157147682Authorship 154948946Authorship 15447005Authorship 15482697Authorship 15442242Authorship 15466049Authorship 155047451Authorship 15465467Authorship 155079910Authorship 15482457Authorship 154694736Authorship 15447522Authorship 15699053Authorship 15441226Authorship 15464026Authorship 155401019Authorship 15448665Authorship 155136723Authorship 15442299Authorship 15503767Authorship 155508852Authorship 15454643Authorship 15457234Authorship 15487868Authorship 15444242Authorship 15442124Authorship 154889744Authorship 15468078Authorship 154868610Authorship 15445183Authorship 15457115Authorship 15445002Authorship 1554874619173696Pan W, Zeng D, Lin XBiometricsEstimation in semiparametric transition measurement error models for longitudinal data. Biometrics. 2009 Sep; 65(3):728-36.Biometrics2009-01-23T00:00:002009Estimation in semiparametric transition measurement error models for longitudinal data.33368361Lin XStatistics in medicineReflections on the 1962 Paper "The Statistician in Medicine" by Sir Austin Bradford Hill. Stat Med. 2021 01 15; 40(1):32-34.Stat Med2021-01-15T00:00:002021Reflections on the 1962 Paper "The Statistician in Medicine" by Sir Austin Bradford Hill.26027497Wang C, Zhan X, Liang L, Abecasis GR, Lin XAmerican journal of human geneticsImproved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation. Am J Hum Genet. 2015 Jun 04; 96(6):926-37.Am J Hum Genet2015-05-28T00:00:002015Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation.16079081Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, Lin X, Parker EA, Israel BA, Gonzalez L, Hill YEnvironmental health perspectivesAir pollution-associated changes in lung function among asthmatic children in Detroit. Environ Health Perspect. 2005 Aug; 113(8):1068-75.Environ Health Perspect2005-08-01T00:00:002005Air pollution-associated changes in lung function among asthmatic children in Detroit.16835283Grewal J, Sowers MR, Randolph JF, Harlow SD, Lin XThe Journal of clinical endocrinology and metabolismLow bone mineral density in the early menopausal transition: role for ovulatory function. J Clin Endocrinol Metab. 2006 Oct; 91(10):3780-5.J Clin Endocrinol Metab2006-07-11T00:00:002006Low bone mineral density in the early menopausal transition: role for ovulatory function.15180671Li L, Lin X, Brown MB, Gupta S, Lee KHBiometricsA population pharmacokinetic model with time-dependent covariates measured with errors. 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Biometrics. 2010 Mar; 66(1):70-8.Biometrics2009-05-07T00:00:002009Bayesian inference in semiparametric mixed models for longitudinal data.12712080Harlow SD, Cohen M, Ohmit SE, Schuman P, Cu-Uvin S, Lin X, Greenblatt R, Gurtman A, Khalsa A, Minkoff H, Young MA, Klein RSAmerican journal of obstetrics and gynecologySubstance use and psychotherapeutic medications: a likely contributor to menstrual disorders in women who are seropositive for human immunodeficiency virus. Am J Obstet Gynecol. 2003 Apr; 188(4):881-6.Am J Obstet Gynecol2003-04-01T00:00:002003Substance use and psychotherapeutic medications: a likely contributor to menstrual disorders in women who are seropositive for human immunodeficiency virus.25997986Huang YT, Liang L, Moffatt MF, Cookson WO, Lin XGenetic epidemiologyiGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis. Genet Epidemiol. 2015 Jul; 39(5):347-56.Genet Epidemiol2015-05-22T00:00:002015iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis.22508067Lee S, Epstein MP, Duncan R, Lin XGenetic epidemiologySparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies. Genet Epidemiol. 2012 May; 36(4):293-302.Genet Epidemiol2012-04-16T00:00:002012Sparse principal component analysis for identifying ancestry-informative markers in genome-wide association studies.32275295Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, Huang J, He N, Yu H, Lin X, Wei S, Wu TJAMAAssociation of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020 May 19; 323(19):1915-1923.JAMA2020-05-19T00:00:002020Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China.15205714Bainbridge KE, Sowers M, Lin X, Harlow SDOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USARisk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women. Osteoporos Int. 2004 Jun; 15(6):439-46.Osteoporos Int2004-01-22T00:00:002004Risk factors for low bone mineral density and the 6-year rate of bone loss among premenopausal and perimenopausal women.33476339Naseri A, Shi J, Lin X, Zhang S, Zhi DPLoS geneticsRAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID. PLoS Genet. 2021 01; 17(1):e1009315.PLoS Genet2021-01-21T00:00:002021RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID.19809573Zeng D, Lin DY, Lin XStatistica SinicaSEMIPARAMETRIC TRANSFORMATION MODELS WITH RANDOM EFFECTS FOR CLUSTERED FAILURE TIME DATA. Stat Sin. 2008 Jan 01; 18(1):355-377.Stat Sin2008-01-01T00:00:002008SEMIPARAMETRIC TRANSFORMATION MODELS WITH RANDOM EFFECTS FOR CLUSTERED FAILURE TIME DATA.23386037Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin XEuropean journal of human genetics : EJHGFamily-based association tests for sequence data, and comparisons with population-based association tests. Eur J Hum Genet. 2013 Oct; 21(10):1158-62.Eur J Hum Genet2013-02-06T00:00:002013Family-based association tests for sequence data, and comparisons with population-based association tests.17688488Zhang D, Lin X, Sowers MBiometricsTwo-stage functional mixed models for evaluating the effect of longitudinal covariate profiles on a scalar outcome. Biometrics. 2007 Jun; 63(2):351-62.Biometrics2007-06-01T00:00:002007Two-stage functional mixed models for evaluating the effect of longitudinal covariate profiles on a scalar outcome.28140654Wijnands KP, Chen J, Liang L, Verbiest MM, Lin X, Helbing WA, Gittenberger-de Groot AC, van der Spek PJ, Uitterlinden AG, Steegers-Theunissen RPEpigenomicsGenome-wide methylation analysis identifies novel CpG loci for perimembranous ventricular septal defects in human. Epigenomics. 2017 03; 9(3):241-251.Epigenomics2017-01-31T00:00:002017Genome-wide methylation analysis identifies novel CpG loci for perimembranous ventricular septal defects in human.37117836Gao X, Coull B, Lin X, Vokonas P, Spiro A, Hou L, Schwartz J, Baccarelli AANature agingPublisher Correction: Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nat Aging. 2021 Jun; 1(6):566.Nat Aging2021-06-01T00:00:002021Publisher Correction: Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study.16135036Roy J, Lin XBiometricsMissing covariates in longitudinal data with informative dropouts: bias analysis and inference. Biometrics. 2005 Sep; 61(3):837-46.Biometrics2005-09-01T00:00:002005Missing covariates in longitudinal data with informative dropouts: bias analysis and inference.15606405Hogan JW, Lin X, Herman BBiometricsMixtures of varying coefficient models for longitudinal data with discrete or continuous nonignorable dropout. Biometrics. 2004 Dec; 60(4):854-64.Biometrics2004-12-01T00:00:002004Mixtures of varying coefficient models for longitudinal data with discrete or continuous nonignorable dropout.15778167Janz NK, Dodge JA, Janevic MR, Lin X, Donaldson AE, Clark NMJournal of women & agingUnderstanding and reducing stress and psychological distress in older women with heart disease. J Women Aging. 2004; 16(3-4):19-38.J Women Aging2004-01-01T00:00:002004Understanding and reducing stress and psychological distress in older women with heart disease.28549425Chen J, Behnam E, Huang J, Moffatt MF, Schaid DJ, Liang L, Lin XBMC genomicsFast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA. BMC Genomics. 2017 05 26; 18(1):413.BMC Genomics2017-05-26T00:00:002017Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA.31564761Liu Z, Lin XJournal of the American Statistical AssociationA Geometric Perspective on the Power of Principal Component Association Tests in Multiple Phenotype Studies. J Am Stat Assoc. 2019; 114(527):975-990.J Am Stat Assoc2019-02-26T00:00:002019A Geometric Perspective on the Power of Principal Component Association Tests in Multiple Phenotype Studies.16011707Nan B, Lin X, Lisabeth LD, Harlow SDBiometricsA varying-coefficient Cox model for the effect of age at a marker event on age at menopause. Biometrics. 2005 Jun; 61(2):576-83.Biometrics2005-06-01T00:00:002005A varying-coefficient Cox model for the effect of age at a marker event on age at menopause.16740859Cabana MD, Slish KK, Evans D, Mellins RB, Brown RW, Lin X, Kaciroti N, Clark NMPediatricsImpact of physician asthma care education on patient outcomes. Pediatrics. 2006 Jun; 117(6):2149-57.Pediatrics2006-06-01T00:00:002006Impact of physician asthma care education on patient outcomes.25270176Cabana MD, Slish KK, Evans D, Mellins RB, Brown RW, Lin X, Kaciroti N, Clark NMHealth education & behavior : the official publication of the Society for Public Health EducationImpact of Physician Asthma Care Education on patient outcomes. 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Genome Med. 2024 Feb 05; 16(1):22.Genome Med2024-02-05T00:00:002024Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification.Authorship 162728736Authorship 16325832Authorship 163155826Authorship 1631653138359790Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin XCell genomicsHost genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation. Cell Genom. 2024 Feb 14; 4(2):100474.Cell Genom2024-01-09T00:00:002024Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation.38362534Lin XHarvard data science reviewLearning Lessons on Reproducibility and Replicability in Large Scale Genome-Wide Association Studies. Harv Data Sci Rev. 2020; 2(4).Harv Data Sci Rev2020-12-16T00:00:002020Learning Lessons on Reproducibility and Replicability in Large Scale Genome-Wide Association Studies.38116301He X, Lin XHarvard data science reviewChallenges and Opportunities in Statistics and Data Science: Ten Research Areas. Harv Data Sci Rev. 2020; 2(3).Harv Data Sci Rev2020-09-30T00:00:002020Challenges and Opportunities in Statistics and Data Science: Ten Research Areas.true1Professor of Statistical GeneticsProfessor of Statistical Genetics3Professor of Biostatistics and StatisticsProfessor of Biostatistics and Statisticstrue1Associate Professor of MedicineAssociate Professor of Medicine2Professor of StatisticsProfessor of Statisticstrue1Peter C. Farrell Professor of Sleep MedicinePeter C. Farrell Professor of Sleep Medicinetrue1Stephen B. Kay Family Professor of Public Health and Clinical EpidemiologyStephen B. Kay Family Professor of Public Health and Clinical Epidemiologytrue1Adjunct Professor of EpidemiologyAdjunct Professor of Epidemiology4Coordinating Director, Program in Quantitative GenomicsCoordinating Director, Program in Quantitative Genomicstrue1Elkan Blout Professor of Environmental GeneticsElkan Blout Professor of Environmental Geneticstrue1Dean of the FacultyDean of the Facultytrue1Professor of BiostatisticsProfessor of BiostatisticsAuthorship 6375066Authorship 6467903Authorship 6503712Authorship 64381510Authorship 6486482Authorship 6379202Authorship 6561137Authorship 6402374Authorship 64249011Authorship 6385724Authorship 6371073Authorship 6424682Authorship 6456617Authorship 6355915Authorship 6586495Authorship 6561737Authorship 6601023Authorship 64415311Authorship 6448664Authorship 6453387Authorship 6419582Authorship 6419475Authorship 6436433Authorship 6485092Authorship 6464422Authorship 6603252Authorship 6427252Authorship 65150914Authorship 6587655Authorship 6544082Authorship 6574072Authorship 6410224Authorship 6411439Authorship 6411692Authorship 6461914Authorship 6472992Authorship 6507441Authorship 64221815Authorship 6580454Authorship 6663853Authorship 6599957Authorship 66061810Authorship 6639763Authorship 66208210Authorship 6634926Authorship 6469874Authorship 6619931012762438Li Y, Lin XBiometricsTesting the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors. Biometrics. 2003 Mar; 59(1):25-35.Biometrics2003-03-01T00:00:002003Testing the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors.18577223Liu D, Ghosh D, Lin XBMC bioinformaticsEstimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics. 2008 Jun 24; 9:292.BMC Bioinformatics2008-06-24T00:00:002008Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models.22070739Yu Z, Lin X, Tu WBiometricsSemiparametric frailty models for clustered failure time data. Biometrics. 2012 Jun; 68(2):429-36.Biometrics2011-11-09T00:00:002011Semiparametric frailty models for clustered failure time data.23755072Li L, Kabesch M, Bouzigon E, Demenais F, Farrall M, Moffatt MF, Lin X, Liang LFrontiers in geneticsUsing eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Front Genet. 2013; 4:103.Front Genet2013-05-31T00:00:002013Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma.12925330Zhang D, Lin XBiostatistics (Oxford, England)Hypothesis testing in semiparametric additive mixed models. Biostatistics. 2003 Jan; 4(1):57-74.Biostatistics2003-01-01T00:00:002003Hypothesis testing in semiparametric additive mixed models.20048386Wu MC, Lin XStatistical methods in medical researchPrior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways. Stat Methods Med Res. 2009 Dec; 18(6):577-93.Stat Methods Med Res2009-12-01T00:00:002009Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways.23806107Huang YT, Lin XBMC bioinformaticsGene set analysis using variance component tests. BMC Bioinformatics. 2013 Jun 28; 14:210.BMC Bioinformatics2013-06-28T00:00:002013Gene set analysis using variance component tests.23643383Schifano ED, Li L, Christiani DC, Lin XAmerican journal of human geneticsGenome-wide association analysis for multiple continuous secondary phenotypes. Am J Hum Genet. 2013 May 02; 92(5):744-59.Am J Hum Genet2013-05-02T00:00:002013Genome-wide association analysis for multiple continuous secondary phenotypes.18080833Lin XLifetime data analysisEstimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models. Lifetime Data Anal. 2007 Dec; 13(4):533-44.Lifetime Data Anal2007-12-16T00:00:002007Estimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models.23184518Barnett IJ, Lee S, Lin XGenetic epidemiologyDetecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol. 2013 Feb; 37(2):142-51.Genet Epidemiol2012-11-26T00:00:002012Detecting rare variant effects using extreme phenotype sampling in sequencing association studies.22699862Lee S, Wu MC, Lin XBiostatistics (Oxford, England)Optimal tests for rare variant effects in sequencing association studies. Biostatistics. 2012 Sep; 13(4):762-75.Biostatistics2012-06-14T00:00:002012Optimal tests for rare variant effects in sequencing association studies.18318038Nan B, Lin XBiometrical journal. Biometrische ZeitschriftAnalysis of case-control age-at-onset data using a modified case-cohort method. Biom J. 2008 Apr; 50(2):311-20.Biom J2008-04-01T00:00:002008Analysis of case-control age-at-onset data using a modified case-cohort method.23768515Lee S, Teslovich TM, Boehnke M, Lin XAmerican journal of human geneticsGeneral framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet. 2013 Jul 11; 93(1):42-53.Am J Hum Genet2013-06-13T00:00:002013General framework for meta-analysis of rare variants in sequencing association studies.Authorship 6733114Authorship 676511423462021Lin X, Lee S, Christiani DC, Lin XBiostatistics (Oxford, England)Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics. 2013 Sep; 14(4):667-81.Biostatistics2013-03-05T00:00:002013Test for interactions between a genetic marker set and environment in generalized linear models.23967108Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DCPloS oneGenetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS One. 2013; 8(8):e70792.PLoS One2013-08-14T00:00:002013Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes.Authorship 6796371123980085Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MHJournal of clinical oncology : official journal of the American Society of Clinical OncologyPrognostic significance of MTOR pathway component expression in neuroendocrine tumors. J Clin Oncol. 2013 Sep 20; 31(27):3418-25.J Clin Oncol2013-08-26T00:00:002013Prognostic significance of MTOR pathway component expression in neuroendocrine tumors.Authorship 691638524166731Wang X, Lee S, Zhu X, Redline S, Lin XGenetic epidemiologyGEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol. 2013 Dec; 37(8):778-86.Genet Epidemiol2013-10-25T00:00:002013GEE-based SNP set association test for continuous and discrete traits in family-based association studies.Authorship 702613223700275Hu T, Lin X, Nan BLifetime data analysisCross-ratio estimation for bivariate failure times with left truncation. Lifetime Data Anal. 2014 Jan; 20(1):23-37.Lifetime Data Anal2013-05-23T00:00:002013Cross-ratio estimation for bivariate failure times with left truncation.24289273Liao SY, Lin X, Christiani DCEnvironmental health : a global access science sourceGene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health. 2013 Dec 01; 12:101.Environ Health2013-12-01T00:00:002013Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study.24677489Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DCEnvironmental and molecular mutagenesisEpigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen. 2014 Jul; 55(6):449-56.Environ Mol Mutagen2014-02-23T00:00:002014Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study.Authorship 7215173Authorship 72208113Authorship 7187423Authorship 720803324475279Wong JY, De Vivo I, Lin X, Fang SC, Christiani DCPloS oneThe relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS One. 2014; 9(1):e87348.PLoS One2014-01-27T00:00:002014The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study.24627998Wong JY, De Vivo I, Lin X, Christiani DCJournal of toxicology and environmental health. Part ACumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes. J Toxicol Environ Health A. 2014; 77(8):441-55.J Toxicol Environ Health A2014-01-01T00:00:002014Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes.24633160Wang C, Zhan X, Bragg-Gresham J, Kang HM, Stambolian D, Chew EY, Branham KE, Heckenlively J, Fulton R, Wilson RK, Mardis ER, Lin X, Swaroop A, Zöllner S, Abecasis GRNature geneticsAncestry estimation and control of population stratification for sequence-based association studies. Nat Genet. 2014 Apr; 46(4):409-15.Nat Genet2014-03-16T00:00:002014Ancestry estimation and control of population stratification for sequence-based association studies.24616077Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DCGenetic epidemiologyThe association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol. 2014 Apr; 38(3):254-64.Genet Epidemiol2014-02-24T00:00:002014The association between global DNA methylation and telomere length in a longitudinal study of boilermakers.Authorship 7323323324824313Cao Y, Lindström S, Schumacher F, Stevens VL, Albanes D, Berndt S, Boeing H, Bueno-de-Mesquita HB, Canzian F, Chamosa S, Chanock SJ, Diver WR, Gapstur SM, Gaziano JM, Giovannucci EL, Haiman CA, Henderson B, Johansson M, Le Marchand L, Palli D, Rosner B, Siddiq A, Stampfer M, Stram DO, Tamimi R, Travis RC, Trichopoulos D, Willett WC, Yeager M, Kraft P, Hsing AW, Pollak M, Lin X, Ma JJournal of the National Cancer InstituteInsulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. J Natl Cancer Inst. 2014 Jun; 106(6):dju085.J Natl Cancer Inst2014-06-01T00:00:002014Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.Authorship 743817925044411Liao SY, Lin X, Christiani DCGenetic epidemiologyGenome-wide association and network analysis of lung function in the Framingham Heart Study. Genet Epidemiol. 2014 Sep; 38(6):572-8.Genet Epidemiol2014-07-08T00:00:002014Genome-wide association and network analysis of lung function in the Framingham Heart Study.Authorship 768153722968922Schifano ED, Epstein MP, Bielak LF, Jhun MA, Kardia SL, Peyser PA, Lin XGenetic epidemiologySNP set association analysis for familial data. Genet Epidemiol. 2012 Dec; 36(8):797-810.Genet Epidemiol2012-09-11T00:00:002012SNP set association analysis for familial data.Authorship 769551225220625Valeri L, Lin X, VanderWeele TJStatistics in medicineMediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model. Stat Med. 2014 Dec 10; 33(28):4875-90.Stat Med2014-09-14T00:00:002014Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model.25395096Carmona JJ, Sofer T, Hutchinson J, Cantone L, Coull B, Maity A, Vokonas P, Lin X, Schwartz J, Baccarelli AAEnvironmental health : a global access science sourceShort-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study. Environ Health. 2014 Nov 13; 13:94.Environ Health2014-11-13T00:00:002014Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study.25512264Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DCBMC public healthHeart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health. 2014 Dec 16; 14:1279.BMC Public Health2014-12-16T00:00:002014Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study.25384732Liao SY, Lin X, Christiani DCAmerican journal of industrial medicineOccupational exposures and longitudinal lung function decline. Am J Ind Med. 2015 Jan; 58(1):14-20.Am J Ind Med2014-11-10T00:00:002014Occupational exposures and longitudinal lung function decline.25657573Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y, Lin X, Neuberg D, Kim J, Christiani DCCancer informaticsMitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival. Cancer Inform. 2015; 14(Suppl 1):1-9.Cancer Inform2015-01-27T00:00:002015Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival.25254322Wei Y, Wang Z, Su L, Chen F, Tejera P, Bajwa EK, Wurfel MM, Lin X, Christiani DCChestPlatelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk. Chest. 2015 Mar; 147(3):607-617.Chest2015-03-01T00:00:002015Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk.Authorship 8195237Authorship 838474926199339Liu CY, Stücker I, Chen C, Goodman G, McHugh MK, D'Amelio AM, Etzel CJ, Li S, Lin X, Christiani DCCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyGenome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2015 Oct; 24(10):1564-73.Cancer Epidemiol Biomarkers Prev2015-07-21T00:00:002015Genome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk.Authorship 858259526644456Umukoro PE, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Christiani DCOccupational and environmental medicineShort-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study. Occup Environ Med. 2016 Feb; 73(2):91-6.Occup Environ Med2015-12-07T00:00:002015Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study.Authorship 8664609Authorship 867482725759212Seow WJ, Pan WC, Kile ML, Tong L, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Kibriya M, Ahsan H, Lin X, Christiani DCCancerA distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer. 2015 Jul 01; 121(13):2222-9.Cancer2015-03-10T00:00:002015A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh.26949872Umukoro PE, Wong JY, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DCJournal of occupational and environmental medicineAre the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation? J Occup Environ Med. 2016 Mar; 58(3):232-7.J Occup Environ Med2016-03-01T00:00:002016Are the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation?26449931Chen J, Just AC, Schwartz J, Hou L, Jafari N, Sun Z, Kocher JP, Baccarelli A, Lin XBioinformatics (Oxford, England)CpGFilter: model-based CpG probe filtering with replicates for epigenome-wide association studies. Bioinformatics. 2016 Feb 01; 32(3):469-71.Bioinformatics2015-10-07T00:00:002015CpGFilter: model-based CpG probe filtering with replicates for epigenome-wide association studies.26949871Umukoro PE, Fan T, Zhang J, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DCJournal of occupational and environmental medicineLong-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders. J Occup Environ Med. 2016 Mar; 58(3):227-31.J Occup Environ Med2016-03-01T00:00:002016Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders.26977737Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline SAmerican journal of respiratory and critical care medicineGenetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):886-897.Am J Respir Crit Care Med2016-10-01T00:00:002016Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.27027516Liang J, Cade BE, Wang H, Chen H, Gleason KJ, Larkin EK, Saxena R, Lin X, Redline S, Zhu XGenetic epidemiologyComparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses. Genet Epidemiol. 2016 Apr; 40(3):222-32.Genet Epidemiol2016-04-01T00:00:002016Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses.Authorship 8769807Authorship 8768861627018471Chen H, Wang C, Conomos MP, Stilp AM, Li Z, Sofer T, Szpiro AA, Chen W, Brehm JM, Celedón JC, Redline S, Papanicolaou GJ, Thornton TA, Laurie CC, Rice K, Lin XAmerican journal of human geneticsControl for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models. Am J Hum Genet. 2016 Apr 07; 98(4):653-66.Am J Hum Genet2016-03-24T00:00:002016Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models.26229047Lin X, Lee S, Wu MC, Wang C, Chen H, Li Z, Lin XBiometricsTest for rare variants by environment interactions in sequencing association studies. Biometrics. 2016 Mar; 72(1):156-64.Biometrics2015-07-30T00:00:002015Test for rare variants by environment interactions in sequencing association studies.2Assistant Professor1Associate Professor0Full Professor26771213Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MHAmerican journal of respiratory and critical care medicineExome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57.Am J Respir Crit Care Med2016-07-01T00:00:002016Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.27492634Du Y, Ter-Minassian M, Brais L, Brooks N, Waldron A, Chan JA, Lin X, Kraft P, Christiani DC, Kulke MHEndocrine-related cancerGenetic associations with neuroendocrine tumor risk: results from a genome-wide association study. Endocr Relat Cancer. 2016 08; 23(8):587-94.Endocr Relat Cancer2016-08-01T00:00:002016Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study.2016-03-31BELLINGER, DAVID C2010-04-12Superfund Metal Mixtures, Biomarkers and NeurodevelopmentP42ES0164542019-06-30HERNAN, MIGUEL2008-09-10Statistical Informatics for Cancer ResearchP01CA1342942019-03-31REDLINE, SUSAN S.2012-09-25Leveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL1133382022-03-31LIN, XIHONG2016-05-02Powering whole genome sequence-based genetic discovery for common human diseasesU01HG0090882007-03-31LIN, XIHONG1997-12-15Statistical Methods for Correlated Biomedical DataR01CA0764042002-11-30LIN, XIHONG1997-12-15NEW MIXED EFFECTS MODELS FOR CORRELATED BIOMEDICAL DATAR29CA0764042014-01-31HERRING, AMY H2009-01-01Workshop for Junior Biostatisticians in Health ResearchR13CA1381382020-06-30LIN, XIHONG2005-07-01Interdisciplinary training: Statistical Genetics/Genomics & Computational BiologyT32GM0748972017-08-31LIN, XIHONG2006-08-01Conferences on Emerging Statistical Issues in Biomedical ResearchR13CA1243652008-08-31LIN, XIHONG2001-03-23Workshop for junior Biostatisticians in Cancer ResearchR13CA0902502016-03-31LIN, XIHONG1997-12-15Statistical Methods for Correlated and High-Dimensional Biomedical DataR37CA0764042029-07-31LIN, XIHONG2015-08-05Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 914120627241694Xing C, M McCarthy J, Dupuis J, Adrienne Cupples L, B Meigs J, Lin X, S Allen AStatistics in medicineRobust analysis of secondary phenotypes in case-control genetic association studies. Stat Med. 2016 10 15; 35(23):4226-37.Stat Med2016-05-30T00:00:002016Robust analysis of secondary phenotypes in case-control genetic association studies.27622342Qian ZR, Li T, Ter-Minassian M, Yang J, Chan JA, Brais LK, Masugi Y, Thiaglingam A, Brooks N, Nishihara R, Bonnemarie M, Masuda A, Inamura K, Kim SA, Mima K, Sukawa Y, Dou R, Lin X, Christiani DC, Schmidlin F, Fuchs CS, Mahmood U, Ogino S, Kulke MHPancreasAssociation Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors. Pancreas. 2016 11; 45(10):1386-1393.Pancreas2016-11-01T00:00:002016Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors.Authorship 9218442Authorship 9194012Authorship 92101218Authorship 9211173Authorship 9223262Authorship 9244842Authorship 9265963Authorship 9221823Authorship 9285886Authorship 92535712Authorship 9279902Authorship 9247256Authorship 9274867Authorship 925785623049127Schwartzman A, Lin XBiometrikaThe effect of correlation in false discovery rate estimation. Biometrika. 2011 Mar; 98(1):199-214.Biometrika2011-03-01T00:00:002011The effect of correlation in false discovery rate estimation.22956855Wang L, Rotnitzky A, Lin X, Millikan RE, Thall PFJournal of the American Statistical AssociationEvaluation of Viable Dynamic Treatment Regimes in a Sequentially Randomized Trial of Advanced Prostate Cancer. J Am Stat Assoc. 2012 Jun; 107(498):493-508.J Am Stat Assoc2012-06-01T00:00:002012Evaluation of Viable Dynamic Treatment Regimes in a Sequentially Randomized Trial of Advanced Prostate Cancer.22822258Hu T, Nan B, Lin X, Robins JMBiometrikaTime-dependent cross ratio estimation for bivariate failure times. Biometrika. 2011 Jun; 98(2):341-354.Biometrika2011-06-01T00:00:002011Time-dependent cross ratio estimation for bivariate failure times.23589664Dicker L, Lin XThe Canadian journal of statistics = Revue canadienne de statistiqueParallelism, uniqueness, and large-sample asymptotics for the Dantzig selector. Can J Stat. 2013 Mar 01; 41(1):23-35.Can J Stat2013-03-01T00:00:002013Parallelism, uniqueness, and large-sample asymptotics for the Dantzig selector.19079778Li Y, Prentice RL, Lin XBiometrikaSemiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data. Biometrika. 2008 Dec; 95(4):947-960.Biometrika2008-12-01T00:00:002008Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data.23144520Wang L, Rotnitzky A, Lin XJournal of the American Statistical AssociationNonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations. J Am Stat Assoc. 2010 Sep; 105(491):1135-1146.J Am Stat Assoc2012-01-01T00:00:002012Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations.24729824Huang YT, Vanderweele TJ, Lin XThe annals of applied statisticsJOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES. Ann Appl Stat. 2014 Mar 01; 8(1):352-376.Ann Appl Stat2014-03-01T00:00:002014JOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES.20046975Li Y, Tang H, Lin XStatistica SinicaSpatial Linear Mixed Models with Covariate Measurement Errors. Stat Sin. 2009; 19(3):1077-1093.Stat Sin2009-01-01T00:00:002009Spatial Linear Mixed Models with Covariate Measurement Errors.27768389Wei Y, Tejera P, Wang Z, Zhang R, Chen F, Su L, Lin X, Bajwa EK, Thompson BT, Christiani DCAmerican journal of respiratory and critical care medicineA Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. Am J Respir Crit Care Med. 2017 05 15; 195(10):1353-1361.Am J Respir Crit Care Med2017-05-15T00:00:002017A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline.20514365Yu Z, Lin XStatistica SinicaSEMIPARAMETRIC REGRESSION WITH TIME-DEPENDENT COEFFICIENTS FOR FAILURE TIME DATA ANALYSIS. Stat Sin. 2010 Apr 01; 20(2):853-869.Stat Sin2010-04-01T00:00:002010SEMIPARAMETRIC REGRESSION WITH TIME-DEPENDENT COEFFICIENTS FOR FAILURE TIME DATA ANALYSIS.23264831Sofer T, Maity A, Coull B, Baccarelli A, Schwartz J, Lin XStatistics in biosciencesMultivariate Gene Selection and Testing in Studying the Exposure Effects on a Gene Set. Stat Biosci. 2012 Nov 01; 4(2):319-338.Stat Biosci2012-11-01T00:00:002012Multivariate Gene Selection and Testing in Studying the Exposure Effects on a Gene Set.27488097He Q, Cai T, Liu Y, Zhao N, Harmon QE, Almli LM, Binder EB, Engel SM, Ressler KJ, Conneely KN, Lin X, Wu MCGenetic epidemiologyPrioritizing individual genetic variants after kernel machine testing using variable selection. 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Bioinformatics. 2007 Sep 15; 23(18):2441-8.Bioinformatics2007-07-11T00:00:002007Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments.20526948Laohaudomchok W, Cavallari JM, Fang SC, Lin X, Herrick RF, Christiani DC, Weisskopf MGJournal of occupational and environmental hygieneAssessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometer. J Occup Environ Hyg. 2010 Aug; 7(8):456-65.J Occup Environ Hyg2010-08-01T00:00:002010Assessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometer.20560208Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, Lin XAmerican journal of human geneticsPowerful SNP-set analysis for case-control genome-wide association studies. 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J Am Stat Assoc. 2017; 112(517):64-76.J Am Stat Assoc2017-05-03T00:00:002017The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies.28754176Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DCEnvironmental health : a global access science sourceGenome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. 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Am J Respir Cell Mol Biol. 2018 03; 58(3):391-401.Am J Respir Cell Mol Biol2018-03-01T00:00:002018Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.18223238Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DCClinical cancer research : an official journal of the American Association for Cancer ResearchVascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res. 2008 Jan 15; 14(2):612-7.Clin Cancer Res2008-01-15T00:00:002008Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer.22863193Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, Christiani DC, Wurfel MM, Lin XAmerican journal of human geneticsOptimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet. 2012 Aug 10; 91(2):224-37.Am J Hum Genet2012-08-02T00:00:002012Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies.Authorship 1023119829082545Barfield R, Shen J, Just AC, Vokonas PS, Schwartz J, Baccarelli AA, VanderWeele TJ, Lin XGenetic epidemiologyTesting for the indirect effect under the null for genome-wide mediation analyses. Genet Epidemiol. 2017 12; 41(8):824-833.Genet Epidemiol2017-10-29T00:00:002017Testing for the indirect effect under the null for genome-wide mediation analyses.TT76TamarSoferTamar Sofer, Ph.D.13538Sofer, TamarAssociate Professor of MedicineAuthorship 1024925429120492Sun R, Carroll RJ, Christiani DC, Lin XBiometricsTesting for gene-environment interaction under exposure misspecification. Biometrics. 2018 06; 74(2):653-662.Biometrics2017-11-09T00:00:002017Testing for gene-environment interaction under exposure misspecification.16311244Su L, Zhou W, Asomaning K, Lin X, Wain JC, Lynch TJ, Liu G, Christiani DCCarcinogenesisGenotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis. 2006 May; 27(5):1024-9.Carcinogenesis2005-11-25T00:00:002005Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.18173220Harezlak J, Wu MC, Wang M, Schwartzman A, Christiani DC, Lin XJournal of proteome researchBiomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data. J Proteome Res. 2008 Jan; 7(1):217-24.J Proteome Res2008-01-04T00:00:002008Biomarker discovery for arsenic exposure using functional data. 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Int J Cancer. 2012 Mar 15; 130(6):1338-46.Int J Cancer2011-08-03T00:00:002011Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).18281657Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DCJournal of clinical oncology : official journal of the American Society of Clinical OncologyVEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2008 Feb 20; 26(6):856-62.J Clin Oncol2008-02-20T00:00:002008VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.22545107Choi H, Wang L, Lin X, Spengler JD, Perera FPPloS oneFetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS One. 2012; 7(4):e35464.PLoS One2012-04-24T00:00:002012Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction.23319495Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MHEndocrine-related cancerClinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr Relat Cancer. 2013 Apr; 20(2):187-96.Endocr Relat Cancer2013-03-22T00:00:002013Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database.Authorship 1034088829263828Carmona JJ, Accomando WP, Binder AM, Hutchinson JN, Pantano L, Izzi B, Just AC, Lin X, Schwartz J, Vokonas PS, Amr SS, Baccarelli AA, Michels KBNPJ genomic medicineEmpirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans. 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J Clin Oncol. 2010 May 10; 28(14):2445-51.J Clin Oncol2010-04-12T00:00:002010Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.21818772Lin X, Cai T, Wu MC, Zhou Q, Liu G, Christiani DC, Lin XGenetic epidemiologyKernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol. 2011 Nov; 35(7):620-31.Genet Epidemiol2011-08-04T00:00:002011Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies.20823122Dicker L, Lin X, Ivanov ARMolecular & cellular proteomics : MCPIncreased power for the analysis of label-free LC-MS/MS proteomics data by combining spectral counts and peptide peak attributes. Mol Cell Proteomics. 2010 Dec; 9(12):2704-18.Mol Cell Proteomics2010-09-07T00:00:002010Increased power for the analysis of label-free LC-MS/MS proteomics data by combining spectral counts and peptide peak attributes.20718043Locke AE, Dooley KJ, Tinker SW, Cheong SY, Feingold E, Allen EG, Freeman SB, Torfs CP, Cua CL, Epstein MP, Wu MC, Lin X, Capone G, Sherman SL, Bean LJGenetic epidemiologyVariation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome. Genet Epidemiol. 2010 Sep; 34(6):613-23.Genet Epidemiol2010-09-01T00:00:002010Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome.22734045Cai T, Lin X, Carroll RJBiostatistics (Oxford, England)Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics. 2012 Sep; 13(4):776-90.Biostatistics2012-06-25T00:00:002012Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test.23060367Seow WJ, Pan WC, Kile ML, Baccarelli AA, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lin X, Christiani DCEnvironmental health perspectivesArsenic reduction in drinking water and improvement in skin lesions: a follow-up study in Bangladesh. Environ Health Perspect. 2012 Dec; 120(12):1733-8.Environ Health Perspect2012-10-10T00:00:002012Arsenic reduction in drinking water and improvement in skin lesions: a follow-up study in Bangladesh.