Li X, Valencia A, McClory H, Sapp E, Kegel KB, Difiglia M
Biochemical and biophysical research communications
Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice. Biochem Biophys Res Commun. 2012 May 18; 421(4):727-30.
Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.
McClory H, Wang X, Sapp E, Gatune LW, Iuliano M, Wu CY, Nathwani G, Kegel-Gleason KB, DiFiglia M, Li X
The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival. Sci Rep. 2018 05 22; 8(1):8000.
The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
Valencia A, Sapp E, Reeves PB, Alexander J, Masso N, Li X, Kegel KB, DiFiglia M
Reagents that block neuronal death from Huntington's disease also curb oxidative stress. Neuroreport. 2012 Jan 04; 23(1):10-5.
Reagents that block neuronal death from Huntington's disease also curb oxidative stress.
Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M
Polyglutamine expansion in huntingtin alters its interaction with phospholipids. J Neurochem. 2009 Sep; 110(5):1585-97.
Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease. J Neurosci. 2010 Mar 31; 30(13):4552-61.
Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiol Dis. 2009 Nov; 36(2):374-83.
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
The recycling endosome and its role in neurological disorders. Prog Neurobiol. 2012 May; 97(2):127-41.
The recycling endosome and its role in neurological disorders.
Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease. J Neurosci Res. 2010 Jan; 88(1):179-90.
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M
Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012 Apr 13; 287(16):13487-99.
Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
Tousley A, Iuliano M, Weisman E, Sapp E, Zhang N, Vodicka P, Alexander J, Aviolat H, Gatune L, Reeves P, Li X, Khvorova A, Ellerby LM, Aronin N, DiFiglia M, Kegel-Gleason KB
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease. J Huntingtons Dis. 2019; 8(1):53-69.
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
John B. Penney, Jr. Professor of Neurology
Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
Bullard Professor of Neurogenetics in the Department of Genetics
Wang X, Weng M, Ke Y, Sapp E, DiFiglia M, Li X
Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Cells. 2020 05 04; 9(5).
Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
Ke Y, Weng M, Chhetri G, Usman M, Li Y, Yu Q, Ding Y, Wang Z, Wang X, Sultana P, DiFiglia M, Li X
Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons. Sci Adv. 2020 11; 6(47).
Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons.
Iuliano M, Seeley C, Sapp E, Jones EL, Martin C, Li X, DiFiglia M, Kegel-Gleason KB
Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum. Front Synaptic Neurosci. 2021; 13:618391.
Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X
Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread. Cells. 2021 03 28; 10(4).
Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Wang Z, Chen Y, Li X, Sultana P, Yin M, Wang Z
Amyloid-ß1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway. Chem Biol Interact. 2019 Jan 25; 298:96-103.
Amyloid-ß1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway.
Sheng J, Olrichs NK, Geerts WJ, Li X, Rehman AU, Gadella BM, Kaloyanova DV, Helms JB
Zinc binding regulates amyloid-like aggregation of GAPR-1. Biosci Rep. 2019 02 28; 39(2).
Zinc binding regulates amyloid-like aggregation of GAPR-1.
Chhetri G, Ke Y, Wang P, Usman M, Li Y, Sapp E, Wang J, Ghosh A, Islam MA, Wang X, Boudi A, DiFiglia M, Li X
Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease. J Cell Biol. 2022 10 03; 221(10).
Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease.
Usman M, Li Y, Ke Y, Chhetri G, Islam MA, Wang Z, Li X
International journal of molecular sciences
Trappc9 Deficiency Impairs the Plasticity of Stem Cells. Int J Mol Sci. 2022 Apr 28; 23(9).
Trappc9 Deficiency Impairs the Plasticity of Stem Cells.
Deehan MA, Kothuis JM, Sapp E, Chase K, Ke Y, Seeley C, Iuliano M, Kim E, Kennington L, Miller R, Boudi A, Shing K, Li X, Pfister E, Anaclet C, Brodsky M, Kegel-Gleason K, Aronin N, DiFiglia M
Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. J Neurosci. 2024 04 03; 44(14).
Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.
Li Y, Usman M, Sapp E, Ke Y, Wang Z, Boudi A, DiFiglia M, Li X
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome. JCI Insight. 2024 Jun 18; 9(15).
Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.
Shanghai Second Medical University, Immunology
Heidelberg University, Molecular and Cell Biology
Wu J, Li J, Gaurav C, Muhammad U, Chen Y, Li X, Chen J, Wang Z
CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation. Gen Psychiatr. 2021; 34(6):e100529.
CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.
Assistant Professor of Otolaryngology Head and Neck Surgery
McClory H, Williams D, Sapp E, Gatune LW, Wang P, DiFiglia M, Li X
Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice. Acta Neuropathol Commun. 2014 Dec 20; 2:179.
Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.
Gkantiragas I, Brügger B, Stüven E, Kaloyanova D, Li XY, Löhr K, Lottspeich F, Wieland FT, Helms JB
Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell. 2001 Jun; 12(6):1819-33.
Sphingomyelin-enriched microdomains at the Golgi complex.
Li X, Kaloyanova D, van Eijk M, Eerland R, van der Goot G, Oorschot V, Klumperman J, Lottspeich F, Starkuviene V, Wieland FT, Helms JB
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure. Mol Biol Cell. 2007 Apr; 18(4):1261-71.
Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.
Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M
A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 2008 Oct 29; 19(16):1643-7.
A function of huntingtin in guanine nucleotide exchange on Rab11.
Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol. 2009 Nov; 29(22):6106-16.
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.