Li, Xueyi
eCommons Login: XL47
first name: Xueyi
last name: Li
coauthor of: DiFiglia, Marian
coauthor of: Kegel, Kimberly
coauthor of: Boudi, Adel
coauthor of: Deehan, Mark
coauthor of: Sobin, Lindsay
full name: Xueyi Li, M.D.
has faculty rank: Assistant Professor
has network: selected publications
has network: research areas
has network: coauthor of
has network: similar to
latitude: 42.37904200000000
longitude: -71.05148100000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 40614
person in primary position: Assistant Professor of Neurology
physical neighbor: Bhattacharyya, Raja
physical neighbor: Hyman, Bradley
physical neighbor: Lillis, Kyle
physical neighbor: Suh, Jaehong
physical neighbor: Tanzi, Rudolph
similar to: DiFiglia, Marian
similar to: Gusella, James
similar to: MacDonald, Marcy
similar to: Wheeler, Vanessa
similar to: Isacson, Ole
type: Agent
type: Person
selected publications: Authorship 1726382
selected publications: Authorship 1726383
selected publications: Authorship 1506553
selected publications: Authorship 1506552
selected publications: Authorship 1726385
selected publications: Authorship 1351811
selected publications: Authorship 1351805
selected publications: Authorship 1351806
selected publications: Authorship 1351807
selected publications: Authorship 1351812
selected publications: Authorship 1351808
selected publications: Authorship 1351813
selected publications: Authorship 1351809
selected publications: Authorship 1351810
selected publications: Authorship 207021
selected publications: Authorship 145271
selected publications: Authorship 20149
selected publications: Authorship 475594
selected publications: Authorship 288550
selected publications: Authorship 322312
selected publications: Authorship 428518
selected publications: Authorship 298684
selected publications: Authorship 420818
selected publications: Authorship 391958
selected publications: Authorship 41295
selected publications: Authorship 19283
education and training: Xinxiang Medical College, Medicine
education and training: Shanghai Second Medical University, Immunology
education and training: Heidelberg University, Molecular and Cell Biology
research areas: rab GTP-Binding Proteins
research areas: Huntington Disease
research areas: Endosomes
research areas: Vesicular Transport Proteins
research areas: Guanine Nucleotide Exchange Factors
mailing address: 114 16th Street
ORCID id: 0000-0002-2010-3432
positions: Assistant Professor of Neurology
phone: 617/726-5762
preferred title: Assistant Professor of Neurology

eCommons Login
tag name: catalyst:eCommonsLogin
type: DatatypeProperty

coauthor of
tag name: prns:coAuthorOf
type: ObjectProperty

end date
tag name: prns:endDate
type: DatatypeProperty

Faculty Rank
type: Class

full name
tag name: prns:fullName
type: DatatypeProperty

author list
tag name: prns:hasAuthorList
type: DatatypeProperty

has faculty rank
tag name: prns:hasFacultyRank
type: ObjectProperty

has network
tag name: prns:hasNetwork
type: ObjectProperty

published in
tag name: prns:hasPublicationVenue
type: DatatypeProperty

information resource reference
tag name: prns:informationResourceReference
type: DatatypeProperty

is primary position
tag name: prns:isPrimaryPosition
type: DatatypeProperty

latitude
tag name: prns:latitude
type: DatatypeProperty

longitude
tag name: prns:longitude
type: DatatypeProperty

photo
tag name: prns:mainImage
type: ObjectProperty

maximum weight
tag name: prns:maxWeight
type: DatatypeProperty

journal title abbreviation
tag name: prns:medlineTA
type: DatatypeProperty

MeSH DescriptorUI
tag name: prns:meshDescriptorUI
type: DatatypeProperty

MeSH semantic group name
tag name: prns:meshSemanticGroupName
type: DatatypeProperty

minimum weight
tag name: prns:minWeight
type: DatatypeProperty

number of authors
tag name: prns:numberOfAuthors
type: DatatypeProperty

number of connections
tag name: prns:numberOfConnections
type: DatatypeProperty

number of publications
tag name: prns:numberOfPublications
type: DatatypeProperty

Person ID
tag name: prns:personId
type: DatatypeProperty

person in primary position
tag name: prns:personInPrimaryPosition
type: ObjectProperty

physical neighbor
tag name: prns:physicalNeighborOf
type: ObjectProperty

position in department
tag name: prns:positionInDepartment
type: ObjectProperty

position in division
tag name: prns:positionInDivision
type: ObjectProperty

predicate node
tag name: prns:predicateNode
type: ObjectProperty

publication date
tag name: prns:publicationDate
type: DatatypeProperty

similar to
tag name: prns:similarTo
type: ObjectProperty

sort order
tag name: prns:sortOrder
type: DatatypeProperty

educational organization
tag name: prns:trainingAtOrganization
type: DatatypeProperty

training location
tag name: prns:trainingLocation
type: DatatypeProperty

uniqueness weight
tag name: prns:uniquenessWeight
type: DatatypeProperty

year
tag name: prns:year
type: DatatypeProperty

Academic Article
type: Class

Article
type: Class

Document
type: Class

PubMed Identifier
tag name: bibo:pmid
type: DatatypeProperty

Address
type: Class

address line 1
tag name: vivo:address1
type: DatatypeProperty

address line 2
tag name: vivo:address2
type: DatatypeProperty

address line 3
tag name: vivo:address3
type: DatatypeProperty

city
tag name: vivo:addressCity
type: DatatypeProperty
type: FunctionalProperty

postal code
tag name: vivo:addressPostalCode
type: DatatypeProperty
type: FunctionalProperty

state or province
tag name: vivo:addressState
type: DatatypeProperty
type: FunctionalProperty

selected publications
tag name: vivo:authorInAuthorship
type: ObjectProperty

author rank in publication
tag name: vivo:authorRank
type: DatatypeProperty
type: FunctionalProperty

Authorship
type: Class

degree earned
tag name: vivo:degreeEarned
type: ObjectProperty

Department
type: Class

Division
type: Class

education and training
tag name: vivo:educationalTraining
type: Class
type: ObjectProperty
label: Educational Training

research areas
tag name: vivo:hasResearchArea
type: ObjectProperty

HR job title
tag name: vivo:hrJobTitle
type: DatatypeProperty

Information Resource
type: Class

linked author
tag name: vivo:linkedAuthor
type: ObjectProperty

linked information resource
tag name: vivo:linkedInformationResource
type: ObjectProperty

mailing address
tag name: vivo:mailingAddress
type: ObjectProperty

major field of degree
tag name: vivo:majorField
type: DatatypeProperty

ORCID id
tag name: vivo:orcidId
type: DatatypeProperty

positions
tag name: vivo:personInPosition
type: ObjectProperty

phone
tag name: vivo:phoneNumber
type: DatatypeProperty

Position
type: Class

position in organization
tag name: vivo:positionInOrganization
type: ObjectProperty

preferred title
tag name: vivo:preferredTitle
type: DatatypeProperty
type: FunctionalProperty

predicate
tag name: rdf:predicate
type: ObjectProperty

type
tag name: rdf:type
type: ObjectProperty

label
tag name: rdfs:label
type: DatatypeProperty

Concept
type: Class

Agent
type: Class

first name
tag name: foaf:firstName
type: DatatypeProperty
type: FunctionalProperty

last name
tag name: foaf:lastName
type: DatatypeProperty
type: FunctionalProperty

Organization
type: Class

Person
type: Class

Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.
PubMed Identifier: 22542623
author list: Li X, Valencia A, McClory H, Sapp E, Kegel KB, Difiglia M
published in: Biochemical and biophysical research communications
information resource reference: Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice. Biochem Biophys Res Commun. 2012 May 18; 421(4):727-30.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2012-04-20T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
PubMed Identifier: 29789657
author list: McClory H, Wang X, Sapp E, Gatune LW, Iuliano M, Wu CY, Nathwani G, Kegel-Gleason KB, DiFiglia M, Li X
published in: Scientific reports
information resource reference: The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival. Sci Rep. 2018 05 22; 8(1):8000.
journal title abbreviation: Sci Rep
publication date: 2018-05-22T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Reagents that block neuronal death from Huntington's disease also curb oxidative stress.
PubMed Identifier: 22045254
author list: Valencia A, Sapp E, Reeves PB, Alexander J, Masso N, Li X, Kegel KB, DiFiglia M
published in: Neuroreport
information resource reference: Reagents that block neuronal death from Huntington's disease also curb oxidative stress. Neuroreport. 2012 Jan 04; 23(1):10-5.
journal title abbreviation: Neuroreport
publication date: 2012-01-04T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
PubMed Identifier: 19566678
author list: Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M
published in: Journal of neurochemistry
information resource reference: Polyglutamine expansion in huntingtin alters its interaction with phospholipids. J Neurochem. 2009 Sep; 110(5):1585-97.
journal title abbreviation: J Neurochem
publication date: 2009-06-29T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.
PubMed Identifier: 20357106
author list: Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease. J Neurosci. 2010 Mar 31; 30(13):4552-61.
journal title abbreviation: J Neurosci
publication date: 2010-03-31T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
PubMed Identifier: 19699304
author list: Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M
published in: Neurobiology of disease
information resource reference: Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiol Dis. 2009 Nov; 36(2):374-83.
journal title abbreviation: Neurobiol Dis
publication date: 2009-08-20T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

The recycling endosome and its role in neurological disorders.
PubMed Identifier: 22037413
author list: Li X, DiFiglia M
published in: Progress in neurobiology
information resource reference: The recycling endosome and its role in neurological disorders. Prog Neurobiol. 2012 May; 97(2):127-41.
journal title abbreviation: Prog Neurobiol
publication date: 2011-10-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
PubMed Identifier: 19642201
author list: Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M
published in: Journal of neuroscience research
information resource reference: Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease. J Neurosci Res. 2010 Jan; 88(1):179-90.
journal title abbreviation: J Neurosci Res
publication date: 2010-01-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.
PubMed Identifier: 22375012
author list: Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M
published in: The Journal of biological chemistry
information resource reference: Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer. J Biol Chem. 2012 Apr 13; 287(16):13487-99.
journal title abbreviation: J Biol Chem
publication date: 2012-02-27T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.
PubMed Identifier: 30594931
author list: Tousley A, Iuliano M, Weisman E, Sapp E, Zhang N, Vodicka P, Alexander J, Aviolat H, Gatune L, Reeves P, Li X, Khvorova A, Ellerby LM, Aronin N, DiFiglia M, Kegel-Gleason KB
published in: Journal of Huntington's disease
information resource reference: Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease. J Huntingtons Dis. 2019; 8(1):53-69.
journal title abbreviation: J Huntingtons Dis
publication date: 2019-01-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Otolaryngology Head and Neck Surgery
type: Department
type: Organization

Guanine Nucleotide Exchange Factors
MeSH DescriptorUI: D020662
MeSH semantic group name: Chemicals & Drugs
number of authors: 339
number of publications: 568
uniqueness weight: 0.739914
type: Concept

Huntington Disease
MeSH DescriptorUI: D006816
MeSH semantic group name: Disorders
number of authors: 244
number of publications: 1179
uniqueness weight: 0.594838
type: Concept

Endosomes
MeSH DescriptorUI: D011992
MeSH semantic group name: Anatomy
number of authors: 312
number of publications: 559
uniqueness weight: 0.766766
type: Concept

Vesicular Transport Proteins
MeSH DescriptorUI: D033921
MeSH semantic group name: Chemicals & Drugs
number of authors: 267
number of publications: 397
uniqueness weight: 0.796581
type: Concept

rab GTP-Binding Proteins
MeSH DescriptorUI: D020691
MeSH semantic group name: Chemicals & Drugs
number of authors: 179
number of publications: 242
uniqueness weight: 0.865403
type: Concept

Genetics
type: Department
type: Organization

Neurology
type: Department
type: Organization

Boston Children's Hospital
type: Organization

Massachusetts General Hospital
type: Organization

Isacson, Ole
eCommons Login: OSI1
first name: Ole
last name: Isacson
full name: Ole Isacson, Dr.Med.Sci, M.B.
has faculty rank: Full Professor
latitude: 42.39465440000000
longitude: -71.19567110000000
Person ID: 16740
person in primary position: Professor of Neurology
type: Agent
type: Person
preferred title: Professor of Neurology

Bhattacharyya, Raja
eCommons Login: RB113
first name: Raja
last name: Bhattacharyya
full name: Raja Bhattacharyya, Ph.D.
has faculty rank: Assistant Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 6519
person in primary position: Assistant Professor of Neurology
type: Agent
type: Person
preferred title: Assistant Professor of Neurology

Kegel, Kimberly
eCommons Login: KBK1
first name: Kimberly
last name: Kegel
full name: Kimberly B. Kegel, Ph.D.
has faculty rank: Assistant Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
Person ID: 88115
person in primary position: Assistant Professor of Neurology
type: Agent
type: Person
preferred title: Assistant Professor of Neurology

Lillis, Kyle
eCommons Login: KPL8
first name: Kyle
last name: Lillis
full name: Kyle Patrick Lillis, Ph.D.
has faculty rank: Assistant Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 15860
person in primary position: Assistant Professor of Neurology
type: Agent
type: Person
preferred title: Assistant Professor of Neurology

Hyman, Bradley
eCommons Login: BTH2
first name: Bradley
last name: Hyman
full name: Bradley Theodore Hyman, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
Person ID: 4393
person in primary position: John B. Penney, Jr. Professor of Neurology
type: Agent
type: Person
preferred title: John B. Penney, Jr. Professor of Neurology

DiFiglia, Marian
eCommons Login: MD6
first name: Marian
last name: DiFiglia
full name: Marian DiFiglia, Ph.D.
has faculty rank: Full Professor
latitude: 42.37730000000000
longitude: -71.05250000000000
Person ID: 3966
person in primary position: Professor of Neurology
type: Agent
type: Person
preferred title: Professor of Neurology

Wheeler, Vanessa
eCommons Login: VCW1
first name: Vanessa
last name: Wheeler
full name: Vanessa Chantal Wheeler, Ph.D.
has faculty rank: Full Professor
latitude: 42.36125700000000
longitude: -71.06552700000000
Person ID: 58568
person in primary position: Professor of Neurology
type: Agent
type: Person
preferred title: Professor of Neurology

Tanzi, Rudolph
eCommons Login: RET2
first name: Rudolph
last name: Tanzi
full name: Rudolph Emile Tanzi, Ph.D.
has faculty rank: Full Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
Person ID: 66118
person in primary position: Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
type: Agent
type: Person
preferred title: Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation

selected publications
maximum weight: 1
minimum weight: 1
number of connections: 26
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/113
predicate: selected publications
type: Network

research areas
maximum weight: 2.6076
minimum weight: 0.00565607
number of connections: 177
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/217
predicate: research areas
type: Network

coauthor of
maximum weight: 3.62424
minimum weight: 0.0232357
number of connections: 6
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/363
predicate: coauthor of
type: Network

similar to
maximum weight: 35.7495
minimum weight: 4.33503
number of connections: 60
predicate node: https://connects.catalyst.harvard.edu/Profiles/profile/494
predicate: similar to
type: Network

Suh, Jaehong
eCommons Login: JS179
first name: Jaehong
last name: Suh
full name: Jaehong Suh, Ph.D.
has faculty rank: Assistant Professor
latitude: 42.37904200000000
longitude: -71.05148100000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 77693
person in primary position: Assistant Professor of Neurology
type: Agent
type: Person
preferred title: Assistant Professor of Neurology

Gusella, James
eCommons Login: JFG2
first name: James
last name: Gusella
full name: James Francis Gusella, Ph.D.
has faculty rank: Full Professor
latitude: 42.36125700000000
longitude: -71.06552700000000
Person ID: 78528
person in primary position: Bullard Professor of Neurogenetics in the Department of Genetics
type: Agent
type: Person
preferred title: Bullard Professor of Neurogenetics in the Department of Genetics

MacDonald, Marcy
eCommons Login: MEM1
first name: Marcy
last name: MacDonald
full name: Marcy Elizabeth MacDonald, Ph.D.
has faculty rank: Full Professor
latitude: 42.36125700000000
longitude: -71.06552700000000
Person ID: 15656
person in primary position: Professor of Neurology
type: Agent
type: Person
preferred title: Professor of Neurology

Boudi, Adel
eCommons Login: AB688
first name: Adel
last name: Boudi
full name: Adel Boudi, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 184474
person in primary position: Research Fellow in Neurology
type: Agent
type: Person
preferred title: Research Fellow in Neurology

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Massachusetts General Hospital

John B. Penney, Jr. Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: John B. Penney, Jr. Professor of Neurology
position in organization: Massachusetts General Hospital

Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
position in organization: Massachusetts General Hospital

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Massachusetts General Hospital

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Deehan, Mark
eCommons Login: MAD69
first name: Mark
last name: Deehan
full name: Mark Anthony Deehan, Ph.D.
has faculty rank: Instructor
Person ID: 187920
person in primary position: Instructor in Neurology
type: Agent
type: Person
preferred title: Instructor in Neurology

Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
PubMed Identifier: 32375403
author list: Wang X, Weng M, Ke Y, Sapp E, DiFiglia M, Li X
published in: Cells
information resource reference: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Cells. 2020 05 04; 9(5).
journal title abbreviation: Cells
publication date: 2020-05-04T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 19283
type: Authorship
author rank in publication: 5
linked author: Li, Xueyi
linked information resource: Sphingomyelin-enriched microdomains at the Golgi complex.

Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons.
PubMed Identifier: 33208359
author list: Ke Y, Weng M, Chhetri G, Usman M, Li Y, Yu Q, Ding Y, Wang Z, Wang X, Sultana P, DiFiglia M, Li X
published in: Science advances
information resource reference: Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons. Sci Adv. 2020 11; 6(47).
journal title abbreviation: Sci Adv
publication date: 2020-11-18T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.
PubMed Identifier: 33815086
author list: Iuliano M, Seeley C, Sapp E, Jones EL, Martin C, Li X, DiFiglia M, Kegel-Gleason KB
published in: Frontiers in synaptic neuroscience
information resource reference: Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum. Front Synaptic Neurosci. 2021; 13:618391.
journal title abbreviation: Front Synaptic Neurosci
publication date: 2021-03-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 145271
type: Authorship
author rank in publication: 3
linked author: Li, Xueyi
linked information resource: Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

Authorship 1351805
type: Authorship
author rank in publication: 6
linked author: Li, Xueyi
linked information resource: Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.

Authorship 1351806
type: Authorship
author rank in publication: 12
linked author: Li, Xueyi
linked information resource: Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons.

Authorship 1351807
type: Authorship
author rank in publication: 6
linked author: Li, Xueyi
linked information resource: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.

Authorship 1351808
type: Authorship
author rank in publication: 11
linked author: Li, Xueyi
linked information resource: Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.

Authorship 1351809
type: Authorship
author rank in publication: 10
linked author: Li, Xueyi
linked information resource: The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

Authorship 1351810
type: Authorship
author rank in publication: 7
linked author: Li, Xueyi
linked information resource: Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.

Authorship 1351811
type: Authorship
author rank in publication: 9
linked author: Li, Xueyi
linked information resource: Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.

Authorship 1351812
type: Authorship
author rank in publication: 4
linked author: Li, Xueyi
linked information resource: Zinc binding regulates amyloid-like aggregation of GAPR-1.

Authorship 1351813
type: Authorship
author rank in publication: 3
linked author: Li, Xueyi
linked information resource: Amyloid-ß1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway.

Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
PubMed Identifier: 33800686
author list: Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X
published in: Cells
information resource reference: Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread. Cells. 2021 03 28; 10(4).
journal title abbreviation: Cells
publication date: 2021-03-28T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Amyloid-ß1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway.
PubMed Identifier: 30399361
author list: Wang Z, Chen Y, Li X, Sultana P, Yin M, Wang Z
published in: Chemico-biological interactions
information resource reference: Amyloid-ß1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway. Chem Biol Interact. 2019 Jan 25; 298:96-103.
journal title abbreviation: Chem Biol Interact
publication date: 2018-11-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Zinc binding regulates amyloid-like aggregation of GAPR-1.
PubMed Identifier: 30700571
author list: Sheng J, Olrichs NK, Geerts WJ, Li X, Rehman AU, Gadella BM, Kaloyanova DV, Helms JB
published in: Bioscience reports
information resource reference: Zinc binding regulates amyloid-like aggregation of GAPR-1. Biosci Rep. 2019 02 28; 39(2).
journal title abbreviation: Biosci Rep
publication date: 2019-02-12T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease.
PubMed Identifier: 36099524
author list: Chhetri G, Ke Y, Wang P, Usman M, Li Y, Sapp E, Wang J, Ghosh A, Islam MA, Wang X, Boudi A, DiFiglia M, Li X
published in: The Journal of cell biology
information resource reference: Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease. J Cell Biol. 2022 10 03; 221(10).
journal title abbreviation: J Cell Biol
publication date: 2022-09-13T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1506552
type: Authorship
author rank in publication: 7
linked author: Li, Xueyi
linked information resource: Trappc9 Deficiency Impairs the Plasticity of Stem Cells.

Authorship 1506553
type: Authorship
author rank in publication: 13
linked author: Li, Xueyi
linked information resource: Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease.

Trappc9 Deficiency Impairs the Plasticity of Stem Cells.
PubMed Identifier: 35563289
author list: Usman M, Li Y, Ke Y, Chhetri G, Islam MA, Wang Z, Li X
published in: International journal of molecular sciences
information resource reference: Trappc9 Deficiency Impairs the Plasticity of Stem Cells. Int J Mol Sci. 2022 Apr 28; 23(9).
journal title abbreviation: Int J Mol Sci
publication date: 2022-04-28T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 20149
type: Authorship
author rank in publication: 6
linked author: Li, Xueyi
linked information resource: Reagents that block neuronal death from Huntington's disease also curb oxidative stress.

Research Fellow in Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Fellow in Neurology
position in organization: Massachusetts General Hospital

Authorship 475594
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: The recycling endosome and its role in neurological disorders.

Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.
PubMed Identifier: 38388424
author list: Deehan MA, Kothuis JM, Sapp E, Chase K, Ke Y, Seeley C, Iuliano M, Kim E, Kennington L, Miller R, Boudi A, Shing K, Li X, Pfister E, Anaclet C, Brodsky M, Kegel-Gleason K, Aronin N, DiFiglia M
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. J Neurosci. 2024 04 03; 44(14).
journal title abbreviation: J Neurosci
publication date: 2024-04-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.
PubMed Identifier: 38889014
author list: Li Y, Usman M, Sapp E, Ke Y, Wang Z, Boudi A, DiFiglia M, Li X
published in: JCI insight
information resource reference: Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome. JCI Insight. 2024 Jun 18; 9(15).
journal title abbreviation: JCI Insight
publication date: 2024-06-18T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Massachusetts General Hospital

Assistant Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Neurology
position in organization: Massachusetts General Hospital

Bullard Professor of Neurogenetics in the Department of Genetics
is primary position: true
position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Bullard Professor of Neurogenetics in the Department of Genetics
position in organization: Massachusetts General Hospital

Authorship 288550
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.

Authorship 1726382
type: Authorship
author rank in publication: 8
linked author: Li, Xueyi
linked information resource: Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome.

Authorship 1726383
type: Authorship
author rank in publication: 13
linked author: Li, Xueyi
linked information resource: Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.

Xinxiang Medical College, Medicine
end date: 06/1992
educational organization: Xinxiang Medical College
training location: He'nan, China
type: EducationalTraining
degree earned: Bachelor
major field of degree: Medicine

Shanghai Second Medical University, Immunology
end date: 06/1995
educational organization: Shanghai Second Medical University
training location: Shanghai, China
type: EducationalTraining
degree earned: Master
major field of degree: Immunology

Heidelberg University, Molecular and Cell Biology
end date: 06/2003
educational organization: Heidelberg University
training location: Heidelberg, Germany
type: EducationalTraining
degree earned: PhD
major field of degree: Molecular and Cell Biology

Authorship 1726385
type: Authorship
author rank in publication: 6
linked author: Li, Xueyi
linked information resource: CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.

CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation.
PubMed Identifier: 34970638
author list: Wu J, Li J, Gaurav C, Muhammad U, Chen Y, Li X, Chen J, Wang Z
published in: General psychiatry
information resource reference: CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation. Gen Psychiatr. 2021; 34(6):e100529.
journal title abbreviation: Gen Psychiatr
publication date: 2021-12-13T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 207021
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.

Instructor in Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Neurology
position in organization: Massachusetts General Hospital

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Massachusetts General Hospital

Assistant Professor of Otolaryngology Head and Neck Surgery
is primary position: true
position in department: Otolaryngology Head and Neck Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Otolaryngology Head and Neck Surgery
position in organization: Boston Children's Hospital

Authorship 298684
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.

Authorship 391958
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: A function of huntingtin in guanine nucleotide exchange on Rab11.

Authorship 322312
type: Authorship
author rank in publication: 4
linked author: Li, Xueyi
linked information resource: Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Authorship 420818
type: Authorship
author rank in publication: 6
linked author: Li, Xueyi
linked information resource: Polyglutamine expansion in huntingtin alters its interaction with phospholipids.

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.
PubMed Identifier: 25526803
author list: McClory H, Williams D, Sapp E, Gatune LW, Wang P, DiFiglia M, Li X
published in: Acta neuropathologica communications
information resource reference: Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice. Acta Neuropathol Commun. 2014 Dec 20; 2:179.
journal title abbreviation: Acta Neuropathol Commun
publication date: 2014-12-20T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Sobin, Lindsay
eCommons Login: LS258
first name: Lindsay
last name: Sobin
full name: Lindsay Sobin, M.D.
has faculty rank: Assistant Professor
Person ID: 140010
person in primary position: Assistant Professor of Otolaryngology Head and Neck Surgery
type: Agent
type: Person
preferred title: Assistant Professor of Otolaryngology Head and Neck Surgery

Authorship 41295
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.

Authorship 428518
type: Authorship
author rank in publication: 1
linked author: Li, Xueyi
linked information resource: Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.

Assistant Professor
sort order: 2
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Sphingomyelin-enriched microdomains at the Golgi complex.
PubMed Identifier: 11408588
author list: Gkantiragas I, Brügger B, Stüven E, Kaloyanova D, Li XY, Löhr K, Lottspeich F, Wieland FT, Helms JB
published in: Molecular biology of the cell
information resource reference: Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell. 2001 Jun; 12(6):1819-33.
journal title abbreviation: Mol Biol Cell
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.
PubMed Identifier: 17251550
author list: Li X, Kaloyanova D, van Eijk M, Eerland R, van der Goot G, Oorschot V, Klumperman J, Lottspeich F, Starkuviene V, Wieland FT, Helms JB
published in: Molecular biology of the cell
information resource reference: Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure. Mol Biol Cell. 2007 Apr; 18(4):1261-71.
journal title abbreviation: Mol Biol Cell
publication date: 2007-01-24T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

A function of huntingtin in guanine nucleotide exchange on Rab11.
PubMed Identifier: 18845944
author list: Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M
published in: Neuroreport
information resource reference: A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 2008 Oct 29; 19(16):1643-7.
journal title abbreviation: Neuroreport
publication date: 2008-10-29T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
PubMed Identifier: 19752198
author list: Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M
published in: Molecular and cellular biology
information resource reference: Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol. 2009 Nov; 29(22):6106-16.
journal title abbreviation: Mol Cell Biol
publication date: 2009-09-14T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

114 16th Street
type: Address
address line 1: Massachusetts General Hospital
address line 2: MIND, Neurology
address line 3: 114 16th Street
city: Charlestown
postal code: 02129
state or province: MA