Dr. Charles R. G. Guttmann is an Associate Professor of Radiology at Harvard Medical School, and the Director of the Center for Neurological Imaging, a multi-disciplinary laboratory at Brigham and Women’s Hospital, combining biomedical and computer scientists/biomedical engineers. His research interests focus on the understanding, modeling, and monitoring of neurological diseases, such as multiple sclerosis (MS) and small vessel disease in aging, by integrating imaging-derived biomarkers with clinical, genetic, immunological, and other biomarkers. To this end his laboratory has developed a large scale repository and image analysis workflow management system that has been in use for close to 20 years, and has been populated with images, image-derived metrics, a variety of genetic and blood biomarkers, as well as clinical information inserted at the time of clinical visits. To date the data repository includes over 25,000 magnetic resonance imaging (MRI) exams and data from over 45,000 clinical visits over the past in 8,556 MS patients. This system has enabled multiple large-scale, cross-disciplinary studies addressing a variety of scientific questions, such as genetic determinants of brain atrophy in MS, association studies between risk factors such as smoking and the progression of disease in MS, as well as prospective longitudinal studies to understand the clinical evolution and pathogenesis of MS, as well as to generate predictive models for use in clinical disease management. His current work includes identifying MRI correlates of fatigue and predictors of response to fatigue management interventions. Other projects in Dr. Guttmann's laboratory include studies on the role of perivascular spaces in sleep, sleep deprivation Alzheimer's Disease, and other neurological conditions; lesion-symptom mapping for image-guided focused ultrasound treatment of essential tremor. Dr. Guttmann is also leading the development of SPINE, a web-based virtual laboratory for collaborative scientific research and education. SPINE integrates data federation, image analysis workflows (automated and interactive), as well as statistical modeling. A differentiating aspect of SPINE is the tight interaction between scientific experimentation on one side, and education and image analysis standardization on the other. This approach includes web-based “club-sourcing” of domain experts and ‘crowdsourcing’ of less educated scientific contributors that can be certified in focused analytical tasks, such as outlining an anatomical structure on a CT or MRI image stack.
Wei X, Warfield SK, Zou KH, Wu Y, Li X, Guimond A, Mugler JP, Benson RR, Wolfson L, Weiner HL, Guttmann CR
Journal of magnetic resonance imaging : JMRI
Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy. J Magn Reson Imaging. 2002 Feb; 15(2):203-9.
Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy.
B. Moraal, P. J. Pouwels, H. Vrenken, C. R. Guttmann, D. S. Meier, R. A. van Schijndel, J. J. Geurts, F. Barkhof.
Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine
Application of single-slab 3D-DIR and 3D-T2, compared to 2D dua-echo T2, in multiple slcerosis patients. Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2006; 14:2116.
Application of single-slab 3D-DIR and 3D-T2, compared to 2D dua-echo T2, in multiple slcerosis patients
Subacute changes in T2 signal evolution: Time-Series Modeling of Degernative and Restorative Processes in MS. Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2006; 14:3115.
Subacute changes in T2 signal evolution: Time-Series Modeling of Degernative and Restorative Processes in MS
Ferrant M, Warfield S.K., Guttmann C.R.G., Mulkern R.V., Jolesz F.A., Kikinis R. 3D image matching using a finite element based elastic deformation model. In: Taylor C, Colchester A, editors (Goos G, Hartmanis J, van Leeuwen J, editors, Lecture notes in computer science, vol. 1679). Proceedings of the 2nd International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI); September 19-22, 1999, Cambridge, UK. Berlin: Springer; 1999. p. 202-209.
Moscufo N, Wakefield DB, Meier DS, Cavallari M, Guttmann CRG, White WB, Wolfson L
Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons. PLoS One. 2018; 13(3):e0194051.
Longitudinal microstructural changes of cerebral white matter and their association with mobility performance in older persons.
Healy BC, Hayden DL, Sampat MP, Bakshi R, Guttmann CR
Unbiased treatment effect estimates by modeling the disease process of multiple sclerosis. J Neurol Sci. 2009 Mar 15; 278(1-2):54-9.
Unbiased treatment effect estimates by modeling the disease process of multiple sclerosis.
Gerig G, Welti D, Guttmann C, Colchester A, Székely G. In: Wells WM, Colchester A, Delp S, editors (Goos G, Hartmanis J, van Leeuwen J, editors, Lecture notes in computer science, vol. 1496). Proceedings of the 1st International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI); October 11-13, 1998, Cambridge, MA. Berlin: Springer; 1998. p. 469-480.
Exploring the discrimination power of the time domain for segmentation and characterization of lesions in serial MR data. 1998.
Exploring the discrimination power of the time domain for segmentation and characterization of lesions in serial MR data
Wei X, Warfield SK, Mulkern RV, Brookeman, JR, Mugler, JP, III, Guttmann, CR.
Multi-contrast high-resolution segmentation of the brain: preliminary report. Radiology. 2000; 217:602.
Multi-contrast high-resolution segmentation of the brain: preliminary report
Functional magnetic resonance imaging using non-Fourier, spatially selective radiofrequency encoding. Magn Reson Med. 1999 Apr; 41(4):759-66.
Functional magnetic resonance imaging using non-Fourier, spatially selective radiofrequency encoding.
Kappos L, Moeri D, Radue EW, Schoetzau A, Schweikert K, Barkhof F, Miller D, Guttmann CR, Weiner HL, Gasperini C, Filippi M
Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group. Lancet. 1999 Mar 20; 353(9157):964-9.
Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group.
Chen NK, Dickey CC, Yoo SS, Guttmann CR, Panych LP
Selection of voxel size and slice orientation for fMRI in the presence of susceptibility field gradients: application to imaging of the amygdala. Neuroimage. 2003 Jul; 19(3):817-25.
Selection of voxel size and slice orientation for fMRI in the presence of susceptibility field gradients: application to imaging of the amygdala.
Moscufo N, Guttmann CR, Meier D, Csapo I, Hildenbrand PG, Healy BC, Schmidt JA, Wolfson L
Brain regional lesion burden and impaired mobility in the elderly. Neurobiol Aging. 2011 Apr; 32(4):646-54.
Brain regional lesion burden and impaired mobility in the elderly.
Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S
A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep; 67(9):1055-61.
A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.
Neema M, Goldberg-Zimring D, Guss ZD, Healy BC, Guttmann CR, Houtchens MK, Weiner HL, Horsfield MA, Hackney DB, Alsop DC, Bakshi R
3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis. Neuroimage. 2009 Jul 01; 46(3):633-41.
3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis.
Hannoun S, Heidelberg D, Hourani R, Nguyen TTT, Brisset JC, Grand S, Kremer S, Bonneville F, Guttmann CRG, Dousset V, Cotton F
Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences. Eur J Radiol. 2018 May; 102:146-151.
Diagnostic value of 3DFLAIR in clinical practice for the detection of infratentorial lesions in multiple sclerosis in regard to dual echo T2 sequences.
Black PMcL, Lampson LA, eds. Astrocytomas: diagnosis, treatment, and biology
Diagnostic imaging of intracranial gliomas. Black PMcL, Lampson LA, eds. Astrocytomas: diagnosis, treatment, and biology. 1993; 37-49.
Diagnostic imaging of intracranial gliomas
Glatard T, Kiar G, Aumentado-Armstrong T, Beck N, Bellec P, Bernard R, Bonnet A, Brown ST, Camarasu-Pop S, Cervenansky F, Das S, Ferreira da Silva R, Flandin G, Girard P, Gorgolewski KJ, Guttmann CRG, Hayot-Sasson V, Quirion PO, Rioux P, Rousseau MÉ, Evans AC
Boutiques: a flexible framework to integrate command-line applications in computing platforms. Gigascience. 2018 05 01; 7(5).
Boutiques: a flexible framework to integrate command-line applications in computing platforms.
Pouwels PJ, Kuijer JP, Mugler JP, Guttmann CR, Barkhof F
Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging. Radiology. 2006 Dec; 241(3):873-9.
Human gray matter: feasibility of single-slab 3D double inversion-recovery high-spatial-resolution MR imaging.
Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F, Inglese M, Guttmann CR, Horsfield MA, Filippi M
MRI in multiple sclerosis: current status and future prospects. Lancet Neurol. 2008 Jul; 7(7):615-25.
MRI in multiple sclerosis: current status and future prospects.
Stankiewicz JM, Neema M, Alsop DC, Healy BC, Arora A, Buckle GJ, Chitnis T, Guttmann CR, Hackney D, Bakshi R
Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study. J Neurol Sci. 2009 Apr 15; 279(1-2):99-105.
Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study.
Mugler JP III, Bao S, Mulkern RV, Guttmann CRG, Jolesz FA, Brookeman JR
Proceedings of the International Society for Magnetic Resonance in Medicine
Three-dimensional FLAIR imaging of the brain. Proceedings of the International Society for Magnetic Resonance in Medicine. 1999; 8.
Three-dimensional FLAIR imaging of the brain
MRI time-series modeling of acute and subacute phases of multiple sclerosis lesions. Neurology. 2005.
MRI time-series modeling of acute and subacute phases of multiple sclerosis lesions
Yoo S-S, Guttmann CRG, Zhao L, Saiviroonporn P, Panych LP
4th International Conference on Functional Mapping of the Human Brain
Adaptive functional MRI using radio-frequency encoding. 4th International Conference on Functional Mapping of the Human Brain. 1998; S541.
Adaptive functional MRI using radio-frequency encoding
S. Egorova, Z. Liptak, L. Liu, D. Meier, N.-K. Chen, R. J. Killiany, M.S. Albert, C.R.G. Guttmann
Accelerated brain parenchymal loss in healthy people above 60. Magnetic Resonance in Medicine. 2005; 761.
Accelerated brain parenchymal loss in healthy people above 60
R.Bakshi, M.Neema, Z.Liptak, R.Betensky, G.Buckle, S.Gauthier, J.Stankiewicz, D.Meier, S.Egorova, A.Arora, V.Dandamudi, C.Batt, Z.Guss, B.Glanz, S.Khoury, C.Guttmann, H.Weiner
Magnetic Resonance Disease Severity Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis. AAN Conference, Boston, MA. 2007.
Magnetic Resonance Disease Severity Scale (MRDSS) Predicts Clinical Progression in Multiple Sclerosis
Zhao L, Bartling S, Mugler JP III, Mulkern RV, Meier D, Panych LP, Becker H, Kikinis R, Brookeman JR, Jolesz FA, Guttmann CRG
International Society for Magnetic Resonance in Medicine
High-resolution MR imaging of the petrous bone using a single-slab three-dimensional T2-weighted fast spin-echo sequence. International Society for Magnetic Resonance in Medicine. 2002; 10:928.
High-resolution MR imaging of the petrous bone using a single-slab three-dimensional T2-weighted fast spin-echo sequence
Koichi Oshio, Laurence P. Panych, Charles R.G. Guttmann
Glanz BI, Holland CM, Amunwa EL, Liptak Z, Houtchens MK, Gauthier SA, Bakshi R, Khoury SK, Guttmann CRG, Weiner HL
Prevalence and pattern of cognitive impairment in early MS. Multiple Sclerosis. 2004; 10:S121.
Prevalence and pattern of cognitive impairment in early MS
Prat A, Saroli T, Guttmann CRG, Weiner HL, Khoury SJ, Antel JP.
Kinin B1 receptor expression on MS T lymphocytes: correlation with new MRI T2 lesions, T2 lesion volume, and EDSS. Neurology. 2000; 54(Suppl):A326.
Kinin B1 receptor expression on MS T lymphocytes: correlation with new MRI T2 lesions, T2 lesion volume, and EDSS
Present and future applications of lasers in neurosurgery. Keio J Med. 1993 Dec; 42(4):169-70.
Present and future applications of lasers in neurosurgery.
Zhao L, Mugler JP III, Wei X, Chen N, Mulkern RV, Panych LP, Richmond N, Skorstad R, Brookeman JR, Hassankhani A, Jolesz FA, Guttmann CRG
A high-resolution clinical whole-brain scan using single-slab three-dimensional T1W, T2W and FLAIR fast spin-echo sequences. International Society for Magnetic Resonance in Medicine. 2002; 10:1294.
A high-resolution clinical whole-brain scan using single-slab three-dimensional T1W, T2W and FLAIR fast spin-echo sequences
Mandel M, Gauthier S, Guttmann CRG, Weiner H, Betensky R
Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression
Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression. 2007; (IN PRESS).
Guttmann CRG, Zientara GP, Kikinis R, Jolesz FA.
Quantitative dynamic analysis of the evolution of multiple sclerosis lesions using optical field flow computation of serial MRI data. Society of Magnetic Resonance,. 1994; 1:173.
Quantitative dynamic analysis of the evolution of multiple sclerosis lesions using optical field flow computation of serial MRI data
Sorond FA, Kiely DK, Galica A, Moscufo N, Serrador JM, Iloputaife I, Egorova S, Dell'Oglio E, Meier DS, Newton E, Milberg WP, Guttmann CR, Lipsitz LA
Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study. Ann Neurol. 2011 Aug; 70(2):213-20.
Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study.
Chen N., Dickey C.C., Guttmann C.R.G., Panych L.P.
Selection of voxel size and slice orientation for fMRI of the amygdala. Neuroimage. 2002; P10183.
Selection of voxel size and slice orientation for fMRI of the amygdala
Wakefield DB, Moscufo N, Guttmann CR, Kuchel GA, Kaplan RF, Pearlson G, Wolfson L
Journal of the American Geriatrics Society
White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults. J Am Geriatr Soc. 2010 Feb; 58(2):275-81.
White matter hyperintensities predict functional decline in voiding, mobility, and cognition in older adults.
Image registration framework for large-scale longitudinal MRI data sets: strategy and validation. Magn Reson Imaging. 2007 Jul; 25(6):889-93.
Image registration framework for large-scale longitudinal MRI data sets: strategy and validation.
Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CR
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol. 2008 Jan; 65(1):94-100.
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia.
Ceccarelli A, Jackson JS, Tauhid S, Arora A, Gorky J, Dell'Oglio E, Bakshi A, Chitnis T, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R, Neema M
AJNR. American journal of neuroradiology
The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2012 Sep; 33(8):1579-85.
The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis.
Holland C.M., Smith E.E., Csapo I., Gurol M.E., Brylka D.A., Guttmann C.R.G., Greenberg S.M.
Proceedings of 15th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine.
Conserved Patterns of White Matter Hyperintensity Distribution in Alzheimer's, Cerebral Amyloid Angiopathy, and Healthy Aging. Proceedings of 15th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2007; 15:2149.
Conserved Patterns of White Matter Hyperintensity Distribution in Alzheimer's, Cerebral Amyloid Angiopathy, and Healthy Aging
Short term Lesion Recovery - A Marker for MS Repair Potential?. AAN Conference, Boston, MA. 2007.
Short term Lesion Recovery - A Marker for MS Repair Potential?
Mugler JP III, Brookeman JR, Mulkern RV, Guttmann CRG, Jolesz FA
T1-weighted and T2-weighted 3D spin-echo-based imaging of the whole brain: 1mm3 resolution in under 10 minutes. International Society for Magnetic Resonance in Medicine. 1998; 3:1959.
T1-weighted and T2-weighted 3D spin-echo-based imaging of the whole brain: 1mm3 resolution in under 10 minutes
Guttmann CRG, Kikinis R, Anderson MC, Jakab M, Weiner HL, Jolesz FA
Monitoring multiple sclerosis: requirements for image segmentation. International Society for Magnetic Resonance in Medicine. 1997; 1:74.
Monitoring multiple sclerosis: requirements for image segmentation
EE Smith, S Egorova, D Blacker, R Killiany, A Muzikansky, BC Dickerson, RE Tanzi, MS Albert, SM Greenberg, CRG Guttmann
Vascular Risks and MRI Measures of White Matter Huperintensities and BRain Atrophy in the Prediction of Cognitive Decline. ICAD Conference. 2006.
Vascular Risks and MRI Measures of White Matter Huperintensities and BRain Atrophy in the Prediction of Cognitive Decline
Guttmann CR, Ahn SS, Hsu L, Kikinis R, Jolesz FA
The evolution of multiple sclerosis lesions on serial MR. AJNR Am J Neuroradiol. 1995 Aug; 16(7):1481-91.
The evolution of multiple sclerosis lesions on serial MR.
SA Gauthier, M Mandel, Z Liptak, B Glanz, R Betensky, G Buckle, R Bakshi, C R G Guttmann, S Khoury, H L Weiner
Predicting Interferon Beta/Glatiramer Acetate Treatment Failures in MS: Four Year Analysis of the CLIMB Study. Charcot MS Symposium in Lisbon. 2005.
Predicting Interferon Beta/Glatiramer Acetate Treatment Failures in MS: Four Year Analysis of the CLIMB Study
Holland CM, Smith EE, Csapo I, Gurol ME, Brylka DA, Killiany RJ, Blacker D, Albert MS, Guttmann CR, Greenberg SM
Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging. Stroke. 2008 Apr; 39(4):1127-33.
Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging.
Wisco JJ, Rosene DL, Killiany RJ, Moss MB, Warfield SK, Egorova S, Wu Y, Liptak Z, Warner J, Guttmann CR
A rhesus monkey reference label atlas for template driven segmentation. J Med Primatol. 2008 Oct; 37(5):250-60.
A rhesus monkey reference label atlas for template driven segmentation.
Healy BC, Ali EN, Guttmann CR, Chitnis T, Glanz BI, Buckle G, Houtchens M, Stazzone L, Moodie J, Berger AM, Duan Y, Bakshi R, Khoury S, Weiner H, Ascherio A
Smoking and disease progression in multiple sclerosis. Arch Neurol. 2009 Jul; 66(7):858-64.
Smoking and disease progression in multiple sclerosis.
Sampat MP, Berger AM, Healy BC, Hildenbrand P, Vass J, Meier DS, Chitnis T, Weiner HL, Bakshi R, Guttmann CR
Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data. AJNR Am J Neuroradiol. 2009 Oct; 30(9):1731-9.
Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data.
Meier DS, Balashov KE, Healy B, Weiner HL, Guttmann CR
Seasonal prevalence of MS disease activity. Neurology. 2010 Aug 31; 75(9):799-806.
Seasonal prevalence of MS disease activity.
Gorman MP, Tillema JM, Ciliax AM, Guttmann CR, Chitnis T
Daclizumab use in patients with pediatric multiple sclerosis. Arch Neurol. 2012 Jan; 69(1):78-81.
Daclizumab use in patients with pediatric multiple sclerosis.
White WB, Jalil F, Wakefield DB, Kaplan RF, Bohannon RW, Hall CB, Moscufo N, Fellows D, Guttmann CRG, Wolfson L
Relationships among clinic, home, and ambulatory blood pressures with small vessel disease of the brain and functional status in older people with hypertension. Am Heart J. 2018 11; 205:21-30.
Relationships among clinic, home, and ambulatory blood pressures with small vessel disease of the brain and functional status in older people with hypertension.
Wei X, Yoo S, Dickey CC, Paralkar G, O’Leary HM, Guttmann CRG, Panych LP
Functional MRI of auditory working memory: reproducibility of activation. International Society for Magnetic Resonance in Medicine. 2002; 10:1497.
Functional MRI of auditory working memory: reproducibility of activation
Proceedings of Workshop: Evaluation of Multiple Sclerosis Lesion Load: Comparison of Multiple Image Processing Techniques,
Highly reproducible MS lesion burden quantitation. Proceedings of Workshop: Evaluation of Multiple Sclerosis Lesion Load: Comparison of Multiple Image Processing Techniques,. 1995; 10.
Highly reproducible MS lesion burden quantitation
Multi-resolution detection of functional activation: percentage enhancement and CNR. International Society for Magnetic Resonance in Medicine. 2000; 940.
Multi-resolution detection of functional activation: percentage enhancement and CNR
Stereotactic fMRI. International Society for Magnetic Resonance in Medicine. 1999; 797.
Mulkern RV, Meng J, Oshio K, Williamson DS, Lilly HS, Guttmann CR, Jaramillo D
Spectroscopic imaging of the knee with line scan CPMG sequences. J Comput Assist Tomogr. 1995 Mar-Apr; 19(2):247-55.
Spectroscopic imaging of the knee with line scan CPMG sequences.
Sampat MP, Healy BC, Meier DS, Dell'Oglio E, Liguori M, Guttmann CR
Disease modeling in multiple sclerosis: assessment and quantification of sources of variability in brain parenchymal fraction measurements. Neuroimage. 2010 Oct 01; 52(4):1367-73.
Disease modeling in multiple sclerosis: assessment and quantification of sources of variability in brain parenchymal fraction measurements.
Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30; 5(11):e14169.
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.
Cohen AB, Neema M, Arora A, Dell'oglio E, Benedict RH, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Ceccarelli A, Klein JP, Stankiewicz JM, Houtchens MK, Buckle GJ, Alsop DC, Guttmann CR, Bakshi R
Journal of neuroimaging : official journal of the American Society of Neuroimaging
The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):122-8.
The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis.
Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL
HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Aug 17; 75(7):634-40.
HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Commowick O, Istace A, Kain M, Laurent B, Leray F, Simon M, Pop SC, Girard P, Améli R, Ferré JC, Kerbrat A, Tourdias T, Cervenansky F, Glatard T, Beaumont J, Doyle S, Forbes F, Knight J, Khademi A, Mahbod A, Wang C, McKinley R, Wagner F, Muschelli J, Sweeney E, Roura E, Lladó X, Santos MM, Santos WP, Silva-Filho AG, Tomas-Fernandez X, Urien H, Bloch I, Valverde S, Cabezas M, Vera-Olmos FJ, Malpica N, Guttmann C, Vukusic S, Edan G, Dojat M, Styner M, Warfield SK, Cotton F, Barillot C
Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure. Sci Rep. 2018 09 12; 8(1):13650.
Objective Evaluation of Multiple Sclerosis Lesion Segmentation using a Data Management and Processing Infrastructure.
A.Berger, Z.Liptak, R.Bakshi, C.Guttmann
Does Medulla Oblongata Atrophy Reflect Spinal Cord Damage in MS?. AAN Conference, Boston, MA. 2007.
Does Medulla Oblongata Atrophy Reflect Spinal Cord Damage in MS?
Dynamic partial Fourier spin-warp imaging with high-resolution phase correction. International Society for Magnetic Resonance in Medicine. 2002; 10:2365.
Dynamic partial Fourier spin-warp imaging with high-resolution phase correction
Yoo SS, O'leary HM, Dickey CC, Wei XC, Guttmann CR, Park HW, Panych LP
Functional asymmetry in human primary auditory cortex: identified from longitudinal fMRI study. Neurosci Lett. 2005 Jul 22-29; 383(1-2):1-6.
Functional asymmetry in human primary auditory cortex: identified from longitudinal fMRI study.
R. Bakshi, M. Neema, M. Houtchens, S. Napoli, V.S.R. Dandamudi, C. De, C.R.G. Guttmann
MRI Meausurement of Whole Spinal Cord Volume at 3T: Reproducibility and Relevance to Multiple Sclerosis. Neurology. 2006.
MRI Meausurement of Whole Spinal Cord Volume at 3T: Reproducibility and Relevance to Multiple Sclerosis
Yoo S-S, Zhao L, Saiviroonporn P, Guttmann CRG, Panych LP
Adaptive functional MRI using non-Fourier encoding. International Society for Magnetic Resonance in Medicine. 1998; 1:303.
Adaptive functional MRI using non-Fourier encoding
Guttmann CRG, Weiner HL, Hsu L, Khoury SJ, Orav EJ, Hohol MJ, Ahn SS, Kikinis R, Jolesz FA. The natural course of relapsing-remitting and chronic progressive multiple sclerosis. International Society for Magnetic Resonance in Medicine, Sidney, Australia, 1998;2:1327.
Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR
Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis. AJNR Am J Neuroradiol. 2008 Sep; 29(8):1465-70.
Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis.
Khoury SJ, Guttmann CR, Orav EJ, Hohol MJ, Ahn SS, Hsu L, Kikinis R, Mackin GA, Jolesz FA, Weiner HL
Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology. 1994 Nov; 44(11):2120-4.
Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden.
Rumbaugh CL, Wang A-M, Tsai FY eds. Cerebrovascular disease: imaging and interventional treatment options.
Magnetic resonance imaging assessment of diffusion and perfusion. Rumbaugh CL, Wang A-M, Tsai FY eds. Cerebrovascular disease: imaging and interventional treatment options. 1995; 364-370.
Magnetic resonance imaging assessment of diffusion and perfusion
Guttmann CR, Kikinis R, Anderson MC, Jakab M, Warfield SK, Killiany RJ, Weiner HL, Jolesz FA
Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility. J Magn Reson Imaging. 1999 Apr; 9(4):509-18.
Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility.
Kikinis R, Shenton ME, Gerig G, Martin J, Anderson M, Metcalf D, Guttmann CR, McCarley RW, Lorensen W, Cline H
Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. J Magn Reson Imaging. 1992 Nov-Dec; 2(6):619-29.
Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging.
Wei X, Warfield S, Zou KH, Wells WM III, Wu Y, Li X, Guimond A, Anderson M, Benson RR, Wolfson L, Jolesz FA, Guttmann CRG
Quantitative analysis of MRI white matter signal abnormalities with high reproducibility and accuracy. International Society for Magnetic Resonance in Medicine. 2001; 9:260.
Quantitative analysis of MRI white matter signal abnormalities with high reproducibility and accuracy
High spatial-temporal resolution EPI with partial odd- and even-Fourier sampling. International Society for Magnetic Resonance in Medicine. 2002; 10:2368.
High spatial-temporal resolution EPI with partial odd- and even-Fourier sampling
Hannoun S, Kocevar G, Durand-Dubief F, Stamile C, Naji A, Cotton F, Cavallari M, Guttmann CRG, Sappey-Marinier D
Evidence of axonal damage in cerebellar peduncles without T2-lesions in multiple sclerosis. Eur J Radiol. 2018 Nov; 108:114-119.
Evidence of axonal damage in cerebellar peduncles without T2-lesions in multiple sclerosis.
Three-dimensional spin-echo-train proton-density-weighted imaging using shaped signal evolutions. International Society for Magnetic Resonance in Medicine. 1999; 1631.
Three-dimensional spin-echo-train proton-density-weighted imaging using shaped signal evolutions. International Society for Magnetic Resonance in Medicine
Kozinska D, Holland CM, Krissian K, Westin CF, Guttmann CR
in Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, edited by Amir A. Amini, Armando Manduca,Proceedings of SPIE
Analysis of geometrical relations between multiple sclerosis lesions and brain vasculature. in Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, edited by Amir A. Amini, Armando Manduca,Proceedings of SPIE. 2004; 5369:328-38.
Analysis of geometrical relations between multiple sclerosis lesions and brain vasculature
Plesniak W, Halle M, Pieper SD, Wells W III, Jakab M, Meier DS, Benton SA, Guttmann CRG, Kikinis R
Proceedings of the 2003 IEEE Visualization
Holographic video display of time-series volumetric medical data. Proceedings of the 2003 IEEE Visualization. 2003; 589-596.
Holographic video display of time-series volumetric medical data
Guttmann CRG, Warfield SK, Guimond A, Kikinis R, Albert MS, Jolesz FA, Weiner HL
Variability of brain atrophy estimates in multiple sclerosis. International Society for Magnetic Resonance in Medicine. 2000; 1188.
Variability of brain atrophy estimates in multiple sclerosis
Panych L.P., Dickey C.C., Yoo S., Wei X., Paralkar G., Guttmann C.R.G.
Variation of motion parameters as to task in fMRI acquisitions. Neuroimage. 2002; P10187.
Variation of motion parameters as to task in fMRI acquisitions
Moraal B, Pouwels PJW, Vrenken H, Guttmann CRG, Meier DS, van Schijndel RA, Geurts JJG, Barkhof F
Multiple Sclerosis Clinical and Laboratory Research. ECTRIMS 2006.
Application of single-slab 3D-FLAIR, 3D-DIR and 3D-T2. Multiple Sclerosis Clinical and Laboratory Research. ECTRIMS 2006. 2006; 12(Suppl 1):S180.
Application of single-slab 3D-FLAIR, 3D-DIR and 3D-T2
Chen NK, Egorova S, Guttmann CR, Panych LP
Functional MRI with variable echo time acquisition. Neuroimage. 2003 Dec; 20(4):2062-70.
Functional MRI with variable echo time acquisition.
Mulkern RV, Meng J, Oshio K, Guttmann CR, Jaramillo D
Bone marrow characterization in the lumbar spine with inner volume spectroscopic CPMG imaging studies. J Magn Reson Imaging. 1994 Jul-Aug; 4(4):585-9.
Bone marrow characterization in the lumbar spine with inner volume spectroscopic CPMG imaging studies.
Meier DS, Weiner HL, Khoury SJ, Guttmann CRG.
Brain and Spinal Cord Atrophy in Multiple Sclerosis
MRI Measures of Pathology and their Relationship to Central Nervous System Atrophy in Multiple Sclerosis. Brain and Spinal Cord Atrophy in Multiple Sclerosis. 2004; 73-112.
MRI Measures of Pathology and their Relationship to Central Nervous System Atrophy in Multiple Sclerosis
Pennec X, Guttmann CRG, Thirion J-P. In: Wells WM, Colchester A, Delp S, editors (Goos G, Hartmanis J, van Leeuwen J, editors,)
Feature-based registration of medical images: estimation and validation of the pose accuracy. Lecture notes in computer science. 1998; 1496:1107-1114.
Feature-based registration of medical images: estimation and validation of the pose accuracy
Warfield S, Dengler J, Zaers J, Guttmann CRG, Wells WM III, Ettinger GJ, Hiller J, Kikinis R
Automatic identification of grey matter structures from MRI to improve the segmentation of white matter lesions. MRCAS 95. 1995; 140-147.
Automatic identification of grey matter structures from MRI to improve the segmentation of white matter lesions
Dickey C.C., Mahvash M., Yoo S., Wei X., Guttmann C.R.G., Paralkar G., McCarley R.W., Panych L.P.
Affect of emotional state on head movement in fMRI. Neuroimage. 2002; P10280.
Affect of emotional state on head movement in fMRI
el-Ouahabi A, Guttmann CR, Hushek SG, Bleier AR, Dashner K, Dikkes P, Black PM, Jolesz FA
MRI guided interstitial laser therapy in a rat malignant glioma model. Lasers Surg Med. 1993; 13(5):503-10.
MRI guided interstitial laser therapy in a rat malignant glioma model.
Guttmann CRG, Wells WM III, Nakajima S, Shinmoto H, Kikinis R, Jolesz FA
Proceedings of the 34th annual meeting of the American Society of Neuroradiology
Integration of contrast-enhanced and native MR imaging in multiple sclerosis. Proceedings of the 34th annual meeting of the American Society of Neuroradiology. 1996; 237-8.
Integration of contrast-enhanced and native MR imaging in multiple sclerosis
Strategy and Validation of Large-Scale MRI Registration Framework. Proceedings of 15th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2007; 15:3712.
Strategy and Validation of Large-Scale MRI Registration Framework
Rexilius J, Warfield SK, Guttmann CRG, Wei X, Benson R, Wolfson L, Shenton M, Handels H, Kikinis R. A novel nonrigid registration algorithm and applications. In: Niessen W.J., Viergever M.A., editors (Goos G, Hartmanis J, van Leeuwen J, editors, Lecture notes in computer science, vol. 2208). Proceedings of the 4th International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI); October 4-17, 2001, Utrecht, The Netherlands. Berlin: Springer; 2001. p. 923-931.
Palmer MR, Kiger WS, Zuo C, Panych LP, Guttmann CRG, Zamenhof RG, Busse PM Planum press, in press
Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer
Integrated medical image registration, patient positioning and patient monitoring for cranial BNCT. Proceedings of the 8th International Symposium on Neutron Capture Therapy for Cancer. 1998.
Integrated medical image registration, patient positioning and patient monitoring for cranial BNCT
Ameli R, Guttmann CRG, Prieto JC, Rollot F, Palotai M, Vukusic S, Marignier R, Cotton F
Journal of neuroradiology = Journal de neuroradiologie
Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease. J Neuroradiol. 2021 May; 48(3):170-175.
Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease.
J. David and Virginia Wimberly Professor of Neurology
Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R
Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 09; 131(3):477-491.
Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence.
Jack, Sadie and David Breakstone Professor of Neurology
Palotai M, Cavallari M, Koubiyr I, Morales Pinzon A, Nazeri A, Healy BC, Glanz B, Weiner HL, Chitnis T, Guttmann CR
Multiple sclerosis (Houndmills, Basingstoke, England)
Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression. Mult Scler. 2020 11; 26(13):1708-1718.
Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression.
Brain anatomical correlates of fatigue in multiple sclerosis. Mult Scler. 2020 06; 26(7):751-764.
Brain anatomical correlates of fatigue in multiple sclerosis.
White WB, Wakefield DB, Moscufo N, Guttmann CRG, Kaplan RF, Bohannon RW, Fellows D, Hall CB, Wolfson L
Effects of Intensive Versus Standard Ambulatory Blood Pressure Control on Cerebrovascular Outcomes in Older People (INFINITY). Circulation. 2019 11 12; 140(20):1626-1635.
Effects of Intensive Versus Standard Ambulatory Blood Pressure Control on Cerebrovascular Outcomes in Older People (INFINITY).
Palotai M, Nazeri A, Cavallari M, Healy BC, Glanz B, Gold SM, Weiner HL, Chitnis T, Guttmann CRG
History of fatigue in multiple sclerosis is associated with grey matter atrophy. Sci Rep. 2019 10 14; 9(1):14781.
History of fatigue in multiple sclerosis is associated with grey matter atrophy.
de Sitter A, Visser M, Brouwer I, Cover KS, van Schijndel RA, Eijgelaar RS, Müller DMJ, Ropele S, Kappos L, Rovira Á, Filippi M, Enzinger C, Frederiksen J, Ciccarelli O, Guttmann CRG, Wattjes MP, Witte MG, de Witt Hamer PC, Barkhof F, Vrenken H
Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods. Eur Radiol. 2020 Feb; 30(2):1062-1074.
Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods.
Palotai M, Cavallari M, Healy BC, Guttmann CR
A novel classification of fatigue in multiple sclerosis based on longitudinal assessments. Mult Scler. 2020 05; 26(6):725-734.
A novel classification of fatigue in multiple sclerosis based on longitudinal assessments.
Brisset JC, Kremer S, Hannoun S, Bonneville F, Durand-Dubief F, Tourdias T, Barillot C, Guttmann C, Vukusic S, Dousset V, Cotton F
New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions. J Neuroradiol. 2020 Jun; 47(4):250-258.
New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions.
Troili F, Cipollini V, Moci M, Morena E, Palotai M, Rinaldi V, Romano C, Ristori G, Giubilei F, Salvetti M, Orzi F, Guttmann CRG, Cavallari M
Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System. Front Neuroanat. 2020; 14:17.
Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System.
Rosso M, Gonzalez CT, Healy BC, Saxena S, Paul A, Bjornevik K, Kuhle J, Benkert P, Leppert D, Guttmann C, Bakshi R, Weiner HL, Chitnis T
Annals of clinical and translational neurology
Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis. Ann Clin Transl Neurol. 2020 06; 7(6):945-955.
Temporal association of sNfL and gad-enhancing lesions in multiple sclerosis.
de Sitter A, Verhoeven T, Burggraaff J, Liu Y, Simoes J, Ruggieri S, Palotai M, Brouwer I, Versteeg A, Wottschel V, Ropele S, Rocca MA, Gasperini C, Gallo A, Yiannakas MC, Rovira A, Enzinger C, Filippi M, De Stefano N, Kappos L, Frederiksen JL, Uitdehaag BMJ, Barkhof F, Guttmann CRG, Vrenken H
Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort. J Neurol. 2020 Dec; 267(12):3541-3554.
Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.
Corrigendum: Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System. Front Neuroanat. 2020; 14:51.
Corrigendum: Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System.
Deol M, Palotai M, Pinzon AM, Marciniak A, Bliault G, Covert E, Aizer A, Guenette JP, Desalvo MN, Li XT, Thomas A, Tran NA, Jacobson A, Huang R, Guttmann CRG
Identification and Characterization of Leptomeningeal Metastases Using SPINE, A Web-Based Collaborative Platform. J Neuroimaging. 2021 03; 31(2):324-333.
Identification and Characterization of Leptomeningeal Metastases Using SPINE, A Web-Based Collaborative Platform.
Burggraaff J, Liu Y, Prieto JC, Simoes J, de Sitter A, Ruggieri S, Brouwer I, Lissenberg-Witte BI, Rocca MA, Valsasina P, Ropele S, Gasperini C, Gallo A, Pareto D, Sastre-Garriga J, Enzinger C, Filippi M, De Stefano N, Ciccarelli O, Hulst HE, Wattjes MP, Barkhof F, Uitdehaag BMJ, Vrenken H, Guttmann CRG
Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study. Neuroimage Clin. 2021; 29:102549.
Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study.
Rosso M, Healy BC, Saxena S, Paul A, Bjornevik K, Kuhle J, Benkert P, Leppert D, Guttmann C, Bakshi R, Weiner HL, Chitnis T
MRI Lesion State Modulates the Relationship Between Serum Neurofilament Light and Age in Multiple Sclerosis. J Neuroimaging. 2021 03; 31(2):388-393.
MRI Lesion State Modulates the Relationship Between Serum Neurofilament Light and Age in Multiple Sclerosis.
Palotai M, Small C, Makris N, Somes NG, Pinzon AM, Rathi Y, Marzullo A, Levitt JJ, Bakshi R, Chitnis T, Guttmann CRG
Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis. J Neuroimaging. 2021 05; 31(3):501-507.
Microstructural Changes in the Left Mesocorticolimbic Pathway are Associated with the Comorbid Development of Fatigue and Depression in Multiple Sclerosis.
Eshaghi A, Young AL, Wijeratne PA, Prados F, Arnold DL, Narayanan S, Guttmann CRG, Barkhof F, Alexander DC, Thompson AJ, Chard D, Ciccarelli O
Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data. Nat Commun. 2021 04 06; 12(1):2078.
Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.
Palotai M, Wallack M, Kujbus G, Dalnoki A, Guttmann C
Usability of a Mobile App for Real-Time Assessment of Fatigue and Related Symptoms in Patients With Multiple Sclerosis: Observational Study. JMIR Mhealth Uhealth. 2021 04 16; 9(4):e19564.
Usability of a Mobile App for Real-Time Assessment of Fatigue and Related Symptoms in Patients With Multiple Sclerosis: Observational Study.
de Sitter A, Burggraaff J, Bartel F, Palotai M, Liu Y, Simoes J, Ruggieri S, Schregel K, Ropele S, Rocca MA, Gasperini C, Gallo A, Schoonheim MM, Amann M, Yiannakas M, Pareto D, Wattjes MP, Sastre-Garriga J, Kappos L, Filippi M, Enzinger C, Frederiksen J, Uitdehaag B, Guttmann CRG, Barkhof F, Vrenken H
Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references. Neuroimage Clin. 2021; 30:102659.
Development and evaluation of a manual segmentation protocol for deep grey matter in multiple sclerosis: Towards accelerated semi-automated references.
Author Correction: Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data. Nat Commun. 2021 May 20; 12(1):3169.
Author Correction: Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.
SPINE: Learn about the brain and accelerate discovery!
Schregel K, Baufeld C, Palotai M, Meroni R, Fiorina P, Wuerfel J, Sinkus R, Zhang YZ, McDannold N, White PJ, Guttmann CRG
Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis. Front Neurosci. 2021; 15:665722.
Targeted Blood Brain Barrier Opening With Focused Ultrasound Induces Focal Macrophage/Microglial Activation in Experimental Autoimmune Encephalomyelitis.
Meier IB, Lao PJ, Gietl A, Vorburger RS, Gutierrez J, Holland CM, Guttmann CRG, Meier DS, Buck A, Nitsch RM, Hock C, Unschuld PG, Brickman AM
Cerebral circulation - cognition and behavior
Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life. Cereb Circ Cogn Behav. 2020; 1.
Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life.
Vrenken H, Jenkinson M, Pham DL, Guttmann CRG, Pareto D, Paardekooper M, de Sitter A, Rocca MA, Wottschel V, Cardoso MJ, Barkhof F
Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence. Neurology. 2021 11 23; 97(21):989-999.
Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence.
Palotai M, Schregel K, Nazari N, Merchant JP, Taylor WM, Guttmann CRG, Sinkus R, Young-Pearse TL, Patz S
Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model. J Neuroimaging. 2022 07; 32(4):617-628.
Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model.
Svoboda E, Boril T, Rusz J, Tykalová T, Horáková D, Guttmann CRG, Blagoev KB, Hatabu H, Valtchinov VI
Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study. Comput Biol Med. 2022 09; 148:105853.
Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study.
Bose G, Healy BC, Barro C, Glanz BI, Lokhande HA, Polgar-Turcsanyi M, Guttmann CR, Bakshi R, Weiner HL, Chitnis T
Journal of neurology, neurosurgery, and psychiatry
Younger age at multiple sclerosis onset is associated with worse outcomes at age 50. J Neurol Neurosurg Psychiatry. 2022 Aug 11.
Younger age at multiple sclerosis onset is associated with worse outcomes at age 50.
Barro C, Healy BC, Liu Y, Saxena S, Paul A, Polgar-Turcsanyi M, Guttmann CRG, Bakshi R, Kropshofer H, Weiner HL, Chitnis T
Neurology(R) neuroimmunology & neuroinflammation
Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2023 01; 10(1).
Serum GFAP and NfL Levels Differentiate Subsequent Progression and Disease Activity in Patients With Progressive Multiple Sclerosis.
Wada N, Li Y, Hino T, Gagne S, Valtchinov VI, Gay E, Nishino M, Madore B, Guttmann CRG, Bond S, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
COVID-19 Vaccination reduced pneumonia severity. Eur J Radiol Open. 2022; 9:100456.
COVID-19 Vaccination reduced pneumonia severity.
Barro C, Healy BC, Saxena S, Glanz BI, Paul A, Polgar-Turcsanyi M, Guttmann CR, Bakshi R, Weiner HL, Chitnis T
Serum NfL but not GFAP predicts cognitive decline in active progressive multiple sclerosis patients. Mult Scler. 2023 02; 29(2):206-211.
Serum NfL but not GFAP predicts cognitive decline in active progressive multiple sclerosis patients.
Tran NA, Palotai M, Hanna GJ, Schoenfeld JD, Bay CP, Rettig EM, Bunch PM, Juliano AF, Kelly HR, Suh CH, Zander DA, Morales Pinzon A, Kann BH, Huang RY, Haddad RI, Guttmann CRG, Guenette JP
Diagnostic performance of computed tomography features in detecting oropharyngeal squamous cell carcinoma extranodal extension. Eur Radiol. 2023 May; 33(5):3693-3703.
Diagnostic performance of computed tomography features in detecting oropharyngeal squamous cell carcinoma extranodal extension.
Palotai M, Pintye D, Glanz B, Chitnis T, Guttmann CRG
Fronto-striatal damage may contribute to resistance to fatigue-lowering medications in multiple sclerosis. J Neuroimaging. 2023 03; 33(2):269-278.
Fronto-striatal damage may contribute to resistance to fatigue-lowering medications in multiple sclerosis.
Bouman PM, Noteboom S, Nobrega Santos FA, Beck ES, Bliault G, Castellaro M, Calabrese M, Chard DT, Eichinger P, Filippi M, Inglese M, Lapucci C, Marciniak A, Moraal B, Morales Pinzon A, Mühlau M, Preziosa P, Reich DS, Rocca MA, Schoonheim MM, Twisk JWR, Wiestler B, Jonkman LE, Guttmann CRG, Geurts JJG, Steenwijk MD
Multicenter Evaluation of AI-generated DIR and PSIR for Cortical and Juxtacortical Multiple Sclerosis Lesion Detection. Radiology. 2023 04; 307(2):e221425.
Multicenter Evaluation of AI-generated DIR and PSIR for Cortical and Juxtacortical Multiple Sclerosis Lesion Detection.
Hino T, Nishino M, Valtchinov VI, Gagne S, Gay E, Wada N, Tseng SC, Madore B, Guttmann CRG, Ishigami K, Li Y, Christiani DC, Hunninghake GM, Levy BD, Kaye KM, Hatabu H
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans. Eur J Radiol Open. 2023; 10:100483.
Severe COVID-19 pneumonia leads to post-COVID-19 lung abnormalities on follow-up CT scans.
Bove R, Musallam A, Healy BC, Houtchens M, Glanz BI, Khoury S, Guttmann CR, De Jager PL, Chitnis T
No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50. BMC Neurol. 2013 Jul 03; 13:73.
No sex-specific difference in disease trajectory in multiple sclerosis patients before and after age 50.
Bose G, Healy BC, Saxena S, Saleh F, Paul A, Barro C, Lokhande HA, Polgar-Turcsanyi M, Anderson M, Glanz BI, Guttmann CRG, Bakshi R, Weiner HL, Chitnis T
Multiple sclerosis and related disorders
Early neurofilament light and glial fibrillary acidic protein levels improve predictive models of multiple sclerosis outcomes. Mult Scler Relat Disord. 2023 Jun; 74:104695.
Early neurofilament light and glial fibrillary acidic protein levels improve predictive models of multiple sclerosis outcomes.
Kletenik I, Cohen AL, Glanz BI, Ferguson MA, Tauhid S, Li J, Drew W, Polgar-Turcsanyi M, Palotai M, Siddiqi SH, Marshall GA, Chitnis T, Guttmann CRG, Bakshi R, Fox MD
Multiple sclerosis lesions that impair memory map to a connected memory circuit. J Neurol. 2023 Nov; 270(11):5211-5222.
Multiple sclerosis lesions that impair memory map to a connected memory circuit.
Wada N, Li Y, Gagne S, Hino T, Valtchinov VI, Gay E, Nishino M, Hammer MM, Madore B, Guttmann CRG, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H
Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants. Medicine (Baltimore). 2023 Dec 01; 102(48):e36417.
Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants.
Illes Z, Jørgensen MM, Bæk R, Bente LM, Lauridsen JT, Hyrlov KH, Aboo C, Baumbach J, Kacprowski T, Cotton F, Guttmann CRG, Stensballe A
New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis. Biomedicines. 2023 Nov 28; 11(12).
New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis.
Cavallari M, Dubost F, Guttmann CRG, Lee-Messer CW
Editorial: Enlarged perivascular spaces: etiology and significance. Front Neurosci. 2023; 17:1321691.
Editorial: Enlarged perivascular spaces: etiology and significance.
Chua MMJ, LeBlang S, Powlovich L, Gilbertson T, Krishna V, Guttmann CRG, Eames MDC, Poulsen FR, Cosgrove GR
Brain targeting for focused ultrasound essential tremor ablation: proceedings from the 2023 Focused Ultrasound Foundation workshop. Neurosurg Focus. 2024 09 01; 57(3):E3.
Brain targeting for focused ultrasound essential tremor ablation: proceedings from the 2023 Focused Ultrasound Foundation workshop.
Gobbi C, Meier DS, Cotton F, Sintzel M, Leppert D, Guttmann CR, Zecca C
Interferon beta 1b following natalizumab discontinuation: one year, randomized, prospective, pilot trial. BMC Neurol. 2013 Aug 02; 13:101.
Interferon beta 1b following natalizumab discontinuation: one year, randomized, prospective, pilot trial.
Kalincik T, Guttmann CR, Krasensky J, Vaneckova M, Lelkova P, Tyblova M, Seidl Z, De Jager PL, Havrdova E, Horakova D
Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome. Genes Immun. 2013 Jun; 14(4):244-8.
Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome.
Clemm von Hohenberg C, Schocke MF, Wigand MC, Nachbauer W, Guttmann CR, Kubicki M, Shenton ME, Boesch S, Egger K
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Radial diffusivity in the cerebellar peduncles correlates with clinical severity in Friedreich ataxia. Neurol Sci. 2013 Aug; 34(8):1459-62.
Radial diffusivity in the cerebellar peduncles correlates with clinical severity in Friedreich ataxia.
Wolfson L, Wakefield DB, Moscufo N, Kaplan RF, Hall CB, Schmidt JA, Guttmann CR, White WB
The journals of gerontology. Series A, Biological sciences and medical sciences
Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons. J Gerontol A Biol Sci Med Sci. 2013 Nov; 68(11):1387-94.
Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons.
Cavallari M, Moscufo N, Skudlarski P, Meier D, Panzer VP, Pearlson GD, White WB, Wolfson L, Guttmann CR
Mobility impairment is associated with reduced microstructural integrity of the inferior and superior cerebellar peduncles in elderly with no clinical signs of cerebellar dysfunction. Neuroimage Clin. 2013; 2:332-40.
Mobility impairment is associated with reduced microstructural integrity of the inferior and superior cerebellar peduncles in elderly with no clinical signs of cerebellar dysfunction.
LaBarre BA, King D, Ploumakis A, Pinzon AM, Guttmann CRG, Patsopoulos N, Chitnis T
bioRxiv : the preprint server for biology
Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs. bioRxiv. 2025 Feb 06.
Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs.
Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26; 81(22):1891-9.
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.
Chua MMJ, Pinzon AM, Neudorfer C, Ng PR, Blitz SE, Meyer GM, Butenko K, Dembek TA, Boutet A, Yang AZ, Schwartz M, Germann J, Lipsman N, Lozano A, Behzadi F, McDannold NJ, Rolston JD, Guttmann CRG, Fox MD, Cosgrove G, Horn A
Optimal focused ultrasound lesion location in essential tremor. Sci Adv. 2025 May 16; 11(20):eadp0532.
Optimal focused ultrasound lesion location in essential tremor.
Mike A, Strammer E, Aradi M, Orsi G, Perlaki G, Hajnal A, Sandor J, Banati M, Illes E, Zaitsev A, Herold R, Guttmann CR, Illes Z
Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study. PLoS One. 2013; 8(12):e82422.
Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study.
Papp KV, Kaplan RF, Springate B, Moscufo N, Wakefield DB, Guttmann CR, Wolfson L
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Processing speed in normal aging: effects of white matter hyperintensities and hippocampal volume loss. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2014; 21(2):197-213.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
Processing speed in normal aging: effects of white matter hyperintensities and hippocampal volume loss.
Purkayastha S, Fadar O, Mehregan A, Salat DH, Moscufo N, Meier DS, Guttmann CR, Fisher ND, Lipsitz LA, Sorond FA
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab. 2014 Feb; 34(2):228-34.
Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage.
Zecca C, Riccitelli GC, Calabrese P, Pravatà E, Candrian U, Guttmann CR, Gobbi C
Treatment satisfaction, adherence and behavioral assessment in patients de-escalating from natalizumab to interferon ß. BMC Neurol. 2014 Feb 28; 14:38.
Treatment satisfaction, adherence and behavioral assessment in patients de-escalating from natalizumab to interferon ß.
Einspänner E, Mattern H, Grossmann H, Khadhraoui E, Müller SJ, Garza AP, Dunay IR, Schregel K, Guttmann CRG, Fuchs E, Behme D
A multimodal 7T MRI and biomarker study reveals reversible brain changes following acute sleep deprivation. Sleep Med. 2026 Jan; 137:108663.
A multimodal 7T MRI and biomarker study reveals reversible brain changes following acute sleep deprivation.
Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs. BMC Med Genomics. 2025 Dec 12; 19(1):13.
Bakshi R, Neema M, Tauhid S, Healy BC, Glanz BI, Kim G, Miller J, Berkowitz JL, Bove R, Houtchens MK, Severson C, Stankiewicz JM, Stazzone L, Chitnis T, Guttmann CR, Weiner HL, Ceccarelli A
An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2. Neuroreport. 2014 Oct 01; 25(14):1156-61.
An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2.
Cavallari M, Moscufo N, Meier D, Skudlarski P, Pearlson GD, White WB, Wolfson L, Guttmann CR
Thalamic fractional anisotropy predicts accrual of cerebral white matter damage in older subjects with small-vessel disease. J Cereb Blood Flow Metab. 2014 Aug; 34(8):1321-7.
Thalamic fractional anisotropy predicts accrual of cerebral white matter damage in older subjects with small-vessel disease.
Cavallari M, Ceccarelli A, Wang GY, Moscufo N, Hannoun S, Matulis CR, Jackson JS, Glanz BI, Bakshi R, Neema M, Guttmann CR
Microstructural changes in the striatum and their impact on motor and neuropsychological performance in patients with multiple sclerosis. PLoS One. 2014; 9(7):e101199.
Microstructural changes in the striatum and their impact on motor and neuropsychological performance in patients with multiple sclerosis.
Egger K, Clemm von Hohenberg C, Schocke MF, Guttmann CR, Wassermann D, Wigand MC, Nachbauer W, Kremser C, Sturm B, Scheiber-Mojdehkar B, Kubicki M, Shenton ME, Boesch S
White matter changes in patients with friedreich ataxia after treatment with erythropoietin. J Neuroimaging. 2014 Sep-Oct; 24(5):504-8.
White matter changes in patients with friedreich ataxia after treatment with erythropoietin.
Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttman B, Yeh A, Rodriguez M, Ness J, Gorman MP, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N, Zivadinov R
Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. BMC Neurol. 2013 Nov 13; 13:173.
Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study.
Cavallari M, Hshieh TT, Guttmann CR, Ngo LH, Meier DS, Schmitt EM, Marcantonio ER, Jones RN, Kosar CM, Fong TG, Press D, Inouye SK, Alsop DC
Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia. Neurobiol Aging. 2015 Jun; 36(6):2122-9.
Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia.
Hannoun S, Roch JA, Durand-Dubief F, Vukusic S, Sappey-Marinier D, Guttmann CR, Cotton F
Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC. Brain Behav. 2015 Feb; 5(2):e00307.
Weekly multimodal MRI follow-up of two multiple sclerosis active lesions presenting a transient decrease in ADC.
Chua AS, Egorova S, Anderson MC, Polgar-Turcsanyi M, Chitnis T, Weiner HL, Guttmann CR, Bakshi R, Healy BC
Using multiple imputation to efficiently correct cerebral MRI whole brain lesion and atrophy data in patients with multiple sclerosis. Neuroimage. 2015 Oct 01; 119:81-8.
Using multiple imputation to efficiently correct cerebral MRI whole brain lesion and atrophy data in patients with multiple sclerosis.
Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models. Neuroimage Clin. 2015; 8:606-10.
Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models.
Abraham HM, Wolfson L, Moscufo N, Guttmann CR, Kaplan RF, White WB
Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons. J Cereb Blood Flow Metab. 2016 Jan; 36(1):132-42.
Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons.
Hshieh TT, Fox ML, Kosar CM, Cavallari M, Guttmann CR, Alsop D, Marcantonio ER, Schmitt EM, Jones RN, Inouye SK
Head circumference as a useful surrogate for intracranial volume in older adults. Int Psychogeriatr. 2016 Jan; 28(1):157-62.
Head circumference as a useful surrogate for intracranial volume in older adults.
Munsch F, Sagnier S, Asselineau J, Bigourdan A, Guttmann CR, Debruxelles S, Poli M, Renou P, Perez P, Dousset V, Sibon I, Tourdias T
Stroke Location Is an Independent Predictor of Cognitive Outcome. Stroke. 2016 Jan; 47(1):66-73.
Stroke Location Is an Independent Predictor of Cognitive Outcome.
Cavallari M, Palotai M, Glanz BI, Egorova S, Prieto JC, Healy BC, Chitnis T, Guttmann CR
Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients. Mult Scler. 2016 12; 22(14):1841-1849.
Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients.
Cavallari M, Dai W, Guttmann CR, Meier DS, Ngo LH, Hshieh TT, Callahan AE, Fong TG, Schmitt E, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Inouye SK, Alsop DC
Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016 Apr; 139(Pt 4):1282-94.
Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI.
Bigourdan A, Munsch F, Coupé P, Guttmann CR, Sagnier S, Renou P, Debruxelles S, Poli M, Dousset V, Sibon I, Tourdias T
Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke. Stroke. 2016 Apr; 47(4):1053-9.
Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke.
Guttmann CR, Rousset M, Roch JA, Hannoun S, Durand-Dubief F, Belaroussi B, Cavallari M, Rabilloud M, Sappey-Marinier D, Vukusic S, Cotton F
Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study. Mult Scler. 2016 05; 22(6):761-9.
Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study.
Stamile C, Kocevar G, Cotton F, Durand-Dubief F, Hannoun S, Frindel C, Guttmann CR, Rousseau D, Sappey-Marinier D
A Sensitive and Automatic White Matter Fiber Tracts Model for Longitudinal Analysis of Diffusion Tensor Images in Multiple Sclerosis. PLoS One. 2016; 11(5):e0156405.
A Sensitive and Automatic White Matter Fiber Tracts Model for Longitudinal Analysis of Diffusion Tensor Images in Multiple Sclerosis.
Cavallari M, Guttmann CR, Jones RN, Inouye SK, Alsop DC
Reply: Neural substrates of vulnerability to post-surgical delirium with prospective diagnosis. Brain. 2016 Oct; 139(Pt 10):e55.
Reply: Neural substrates of vulnerability to post-surgical delirium with prospective diagnosis.
Hshieh TT, Dai W, Cavallari M, Guttmann CR, Meier DS, Schmitt EM, Dickerson BC, Press DZ, Marcantonio ER, Jones RN, Gou YR, Travison TG, Fong TG, Ngo L, Inouye SK, Alsop DC
Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1386-1397.
Cerebral blood flow MRI in the nondemented elderly is not predictive of post-operative delirium but is correlated with cognitive performance.
Mandel M, Gauthier SA, Guttmann CR, Weiner HL, Betensky RA
Journal of the American Statistical Association
Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression. J Am Stat Assoc. 2007 12; 102(480):1254-1266.
Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression.
Moroso A, Ruet A, Lamargue-Hamel D, Munsch F, Deloire M, Coupé P, Ouallet JC, Planche V, Moscufo N, Meier DS, Tourdias T, Guttmann CR, Dousset V, Brochet B
Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2017 Feb; 88(2):146-151.
Posterior lobules of the cerebellum and information processing speed at various stages of multiple sclerosis.
Planche V, Ruet A, Coupé P, Lamargue-Hamel D, Deloire M, Pereira B, Manjon JV, Munsch F, Moscufo N, Meier DS, Guttmann CR, Dousset V, Brochet B, Tourdias T
Hippocampal microstructural damage correlates with memory impairment in clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler. 2017 Aug; 23(9):1214-1224.
Hippocampal microstructural damage correlates with memory impairment in clinically isolated syndrome suggestive of multiple sclerosis.
Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS
The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative. Nat Rev Neurol. 2016 12; 12(12):714-722.
The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.
Mulkern RV, Bowers JL, Heff A, Guttmann CR, Sadowski RH
Triexponential decomposition of 1H spin-lattice relaxation decay curves of paramagnetically doped red cell suspensions at 7 T. Phys Med Biol. 1996 Feb; 41(2):255-68.
Triexponential decomposition of 1H spin-lattice relaxation decay curves of paramagnetically doped red cell suspensions at 7 T.
Guttmann CR, Benson R, Warfield SK, Wei X, Anderson MC, Hall CB, Abu-Hasaballah K, Mugler JP, Wolfson L
White matter abnormalities in mobility-impaired older persons. Neurology. 2000 Mar 28; 54(6):1277-83.
White matter abnormalities in mobility-impaired older persons.
Multiresolution data acquisition and detection in functional MRI. Neuroimage. 2001 Dec; 14(6):1476-85.
Multiresolution data acquisition and detection in functional MRI.
Warfield S, Dengler J, Zaers J, Guttmann CR, Wells WM, Ettinger GJ, Hiller J, Kikinis R
Automatic identification of gray matter structures from MRI to improve the segmentation of white matter lesions. J Image Guid Surg. 1995; 1(6):326-38.
Automatic identification of gray matter structures from MRI to improve the segmentation of white matter lesions.
Healy BC, Buckle GJ, Ali EN, Egorova S, Khalid F, Tauhid S, Glanz BI, Chitnis T, Guttmann CRG, Weiner HL, Bakshi R
Characterizing Clinical and MRI Dissociation in Patients with Multiple Sclerosis. J Neuroimaging. 2017 09; 27(5):481-485.
Characterizing Clinical and MRI Dissociation in Patients with Multiple Sclerosis.
Pelletier J, Suchet L, Witjas T, Habib M, Guttmann CR, Salamon G, Lyon-Caen O, Chérif AA
A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis. Arch Neurol. 2001 Jan; 58(1):105-11.
A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis.
Gerig G, Welti D, Guttmann CR, Colchester AC, Székely G
Exploring the discrimination power of the time domain for segmentation and characterization of active lesions in serial MR data. Med Image Anal. 2000 Mar; 4(1):31-42.
Exploring the discrimination power of the time domain for segmentation and characterization of active lesions in serial MR data.
Liu L, Meier D, Polgar-Turcsanyi M, Karkocha P, Bakshi R, Guttmann CR
Multiple sclerosis medical image analysis and information management. J Neuroimaging. 2005; 15(4 Suppl):103S-117S.
Multiple sclerosis medical image analysis and information management.
MRI time series modeling of MS lesion development. Neuroimage. 2006 Aug 15; 32(2):531-7.
MRI time series modeling of MS lesion development.
Kikinis R, Guttmann CR, Metcalf D, Wells WM, Ettinger GJ, Weiner HL, Jolesz FA
Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects. J Magn Reson Imaging. 1999 Apr; 9(4):519-30.
Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects.
Wisco JJ, Killiany RJ, Guttmann CR, Warfield SK, Moss MB, Rosene DL
An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging. 2008 Oct; 29(10):1563-75.
An MRI study of age-related white and gray matter volume changes in the rhesus monkey.
Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL
Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler. 2007 Sep; 13(8):1004-10.
Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis.
Simplified MRI prediction of clinically definite multiple sclerosis: a stepping stone towards treatment criteria? Nat Clin Pract Neurol. 2008 Mar; 4(3):136-7.
Simplified MRI prediction of clinically definite multiple sclerosis: a stepping stone towards treatment criteria?
Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ
CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16; 71(12):917-24.
CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.
Wei X, Guttmann CR, Warfield SK, Eliasziw M, Mitchell JR
Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed? Mult Scler. 2004 Aug; 10(4):402-6.
Has your patient's multiple sclerosis lesion burden or brain atrophy actually changed?
Khoury SJ, Orav EJ, Guttmann CR, Kikinis R, Jolesz FA, Weiner HL
Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis. Neurology. 1999 Sep 11; 53(4):758-64.
Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis.
Meyer B, Guttmann C, Dittrich E, Schmaldienst S, Thalhammer F
Intermittent administration of betalactam-antibiotics for treatment of severe infection in hemodialysis patients. Eur J Med Res. 2005 Apr 20; 10(4):140-4.
Intermittent administration of betalactam-antibiotics for treatment of severe infection in hemodialysis patients.
Zhao Y, Healy BC, Rotstein D, Guttmann CR, Bakshi R, Weiner HL, Brodley CE, Chitnis T
Exploration of machine learning techniques in predicting multiple sclerosis disease course. PLoS One. 2017; 12(4):e0174866.
Exploration of machine learning techniques in predicting multiple sclerosis disease course.
Deutsche medizinische Wochenschrift (1946)
[Chronic obstructive pulmonary disease: pathophysiology, diagnosis, and therapy]. Dtsch Med Wochenschr. 2011 Sep; 136(37):1847-60; quiz 1861-2.
[Chronic obstructive pulmonary disease: pathophysiology, diagnosis, and therapy].
Milles J, Zhu YM, Chen NK, Panych LP, Gimenez G, Guttmann CR
IEEE transactions on bio-medical engineering
Computation of transmitted and received B1 fields in magnetic resonance imaging. IEEE Trans Biomed Eng. 2006 May; 53(5):885-95.
Computation of transmitted and received B1 fields in magnetic resonance imaging.
Guttmann CR, Jolesz FA, Kikinis R, Killiany RJ, Moss MB, Sandor T, Albert MS
White matter changes with normal aging. Neurology. 1998 Apr; 50(4):972-8.
Benson RR, Guttmann CR, Wei X, Warfield SK, Hall C, Schmidt JA, Kikinis R, Wolfson LI
Older people with impaired mobility have specific loci of periventricular abnormality on MRI. Neurology. 2002 Jan 08; 58(1):48-55.
Older people with impaired mobility have specific loci of periventricular abnormality on MRI.
Meier DS, Weiner HL, Khoury SJ, Guttmann CR
Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy. J Neuroimaging. 2004 Jul; 14(3 Suppl):46S-53S.
Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy.
Topics in magnetic resonance imaging : TMRI
Image processing: global and regional changes with age. Top Magn Reson Imaging. 2004 Dec; 15(6):349-53.
Image processing: global and regional changes with age.
Mulkern RV, Zengingonul HP, Robertson RL, Bogner P, Zou KH, Gudbjartsson H, Guttmann CR, Holtzman D, Kyriakos W, Jolesz FA, Maier SE
Multi-component apparent diffusion coefficients in human brain: relationship to spin-lattice relaxation. Magn Reson Med. 2000 Aug; 44(2):292-300.
Multi-component apparent diffusion coefficients in human brain: relationship to spin-lattice relaxation.
White WB, Wolfson L, Wakefield DB, Hall CB, Campbell P, Moscufo N, Schmidt J, Kaplan RF, Pearlson G, Guttmann CR
Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people. Circulation. 2011 Nov 22; 124(21):2312-9.
Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people.
Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han XM, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CR, Weiner HL, Neema M, Bakshi R
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. J Neurol Sci. 2012 Apr 15; 315(1-2):49-54.
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.
White WB, Marfatia R, Schmidt J, Wakefield DB, Kaplan RF, Bohannon RW, Hall CB, Guttmann CR, Moscufo N, Fellows D, Wolfson L
INtensive versus standard ambulatory blood pressure lowering to prevent functional DeclINe in the ElderlY (INFINITY). Am Heart J. 2013 Mar; 165(3):258-265.e1.
INtensive versus standard ambulatory blood pressure lowering to prevent functional DeclINe in the ElderlY (INFINITY).
Goldberg-Zimring D, Achiron A, Guttmann CRG, Azhari H
Analysis of individual changes of multiple sclerosis lesions’ 3-D geometry over time using spherical harmonics. International Society for Magnetic Resonance in Medicine. 2002; 10:1197.
Analysis of individual changes of multiple sclerosis lesions’ 3-D geometry over time using spherical harmonics
Overlay of tinted images for visualizing change in serial radiologic images.
Overlay of tinted images for visualizing change in serial radiologic images. 2008.
Overlay of tinted images for visualizing change in serial radiologic images
Mulkern RV, Gudbjartsson H, Westin CF, Zengingonul HP, Gartner W, Guttmann CR, Robertson RL, Kyriakos W, Schwartz R, Holtzman D, Jolesz FA, Maier SE
Multi-component apparent diffusion coefficients in human brain. NMR Biomed. 1999 Feb; 12(1):51-62.
Multi-component apparent diffusion coefficients in human brain.
Bridges KR, Barabino GD, Brugnara C, Cho MR, Christoph GW, Dover G, Ewenstein BM, Golan DE, Guttmann CR, Hofrichter J, Mulkern RV, Zhang B, Eaton WA
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood. 1996 Dec 15; 88(12):4701-10.
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy.
MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability. AJNR Am J Neuroradiol. 2007 Nov-Dec; 28(10):1956-63.
MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability.
Schwartz RB, Hsu L, Kacher DF, Wong TZ, Alexander E, Okon S, Guttmann CR, Black PM, Kelley RA, Moriarty T, Martin C, Isbister HG, Cahill CD, Spaulding SA, Jolesz FA
Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy. J Magn Reson Imaging. 1998 Sep-Oct; 8(5):1085-9.
Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy.
Kleine LJ, Mulkern RV, Guttmann CR, Colucci VM, Jolesz FA
In vivo characterization of cytotoxic intracellular edema by multicomponent analysis of transverse magnetization decay curves. Acad Radiol. 1995 May; 2(5):365-72.
In vivo characterization of cytotoxic intracellular edema by multicomponent analysis of transverse magnetization decay curves.
Weiner HL, Guttmann CR, Khoury SJ, Orav EJ, Hohol MJ, Kikinis R, Jolesz FA
Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage. J Neuroimmunol. 2000 May 01; 104(2):164-73.
Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage.
Khoury SJ, Guttmann CR, Orav EJ, Kikinis R, Jolesz FA, Weiner HL
Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol. 2000 Aug; 57(8):1183-9.
Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis.
Moscufo N, Wolfson L, Meier D, Liguori M, Hildenbrand PG, Wakefield D, Schmidt JA, Pearlson GD, Guttmann CR
Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum. Age (Dordr). 2012 Apr; 34(2):405-14.
Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum.
Goldberg-Zimring D, Achiron A, Warfield SK, Guttmann CR, Azhari H
Application of spherical harmonics derived space rotation invariant indices to the analysis of multiple sclerosis lesions' geometry by MRI. Magn Reson Imaging. 2004 Jul; 22(6):815-25.
Application of spherical harmonics derived space rotation invariant indices to the analysis of multiple sclerosis lesions' geometry by MRI.
Houtchens MK, Benedict RH, Killiany R, Sharma J, Jaisani Z, Singh B, Weinstock-Guttman B, Guttmann CR, Bakshi R
Thalamic atrophy and cognition in multiple sclerosis. Neurology. 2007 Sep 18; 69(12):1213-23.
Thalamic atrophy and cognition in multiple sclerosis.
Goldberg-Zimring D, Achiron A, Guttmann CR, Azhari H
Three-dimensional analysis of the geometry of individual multiple sclerosis lesions: detection of shape changes over time using spherical harmonics. J Magn Reson Imaging. 2003 Sep; 18(3):291-301.
Three-dimensional analysis of the geometry of individual multiple sclerosis lesions: detection of shape changes over time using spherical harmonics.
Mugler JP, Bao S, Mulkern RV, Guttmann CR, Robertson RL, Jolesz FA, Brookeman JR
Optimized single-slab three-dimensional spin-echo MR imaging of the brain. Radiology. 2000 Sep; 216(3):891-9.
Optimized single-slab three-dimensional spin-echo MR imaging of the brain.
Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y, Buckle GJ, Glanz BI, Stazzone L, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R
Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging. 2009 Jan; 19(1):3-8.
Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis.
Dewey J, Hana G, Russell T, Price J, McCaffrey D, Harezlak J, Sem E, Anyanwu JC, Guttmann CR, Navia B, Cohen R, Tate DF
Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study. Neuroimage. 2010 Jul 15; 51(4):1334-44.
Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study.
Jefferson AL, Holland CM, Tate DF, Csapo I, Poppas A, Cohen RA, Guttmann CR
Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output. Neurobiol Aging. 2011 Jan; 32(1):133-9.
Atlas-derived perfusion correlates of white matter hyperintensities in patients with reduced cardiac output.
Functional MRI using non-Fourier encoding. International Society for Magnetic Resonance in Medicine. 1997; 3:1636.
Functional MRI using non-Fourier encoding
Guttmann CRG, Bridges KR, Brugnara C, Dover GJ, Mulkern RV
Hydroxyurea treatment of sickle cell patients significantly alters red cell T2 relaxation times. Society of Magnetic Resonance. 1994; 3:1360.
Hydroxyurea treatment of sickle cell patients significantly alters red cell T2 relaxation times
Zhao L, Mugler JP, Li X, Wei X, Mulkern RV, Panych LP, Brookman JR, Jolesz FA, Guttmann CRG.
Single-slab three-dimensional T2-weighted fast spin-echo MR imaging of multiple sclerosis patients. Radiology. 2001; 221:140.
Single-slab three-dimensional T2-weighted fast spin-echo MR imaging of multiple sclerosis patients
Subacute Changes in T2 Signal Evolution: Time-Series Modeling of Degenerative and Restorative Processes in MS. Magnetic Resonance in Medicine. 2006.
Subacute Changes in T2 Signal Evolution: Time-Series Modeling of Degenerative and Restorative Processes in MS
Magnetic resonance imaging and multiple sclerosis: what does it tell us?. Multiple Sclerosis Quarterly Report. 2001; 20:1-5.
Magnetic resonance imaging and multiple sclerosis: what does it tell us?
Kacher DF, Zhao L, Kyriakos WE, Madore B, Jevtic J, Mulkern RV, Guttmann CRG, Jolesz FA
Use of Parallel Imaging to Reduce Scanning Time for Single-Slab 3D FSE FLAIR. American Society of Neuroradiology. 2001; 1013.
Use of Parallel Imaging to Reduce Scanning Time for Single-Slab 3D FSE FLAIR
Y. Duan, N. Moscufo, P. J. Pouwels, I. I. Geurts, B. Moraal, S. Warfield, D. S. Meier, F. Barkhof, C. R. Guttmann
Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine.
Synergies of High-Resolution Multi-Channel Lesion Segmentation in multiple Sclerosis: MPRAGE, 3D FLAIR, 3D T2WI and 3D DIR. Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2006; 14:3116.
Synergies of High-Resolution Multi-Channel Lesion Segmentation in multiple Sclerosis: MPRAGE, 3D FLAIR, 3D T2WI and 3D DIR
A simple non-invasive stereotactic device for routine MR head examinations. Society of Magnetic Resonance. 1995; 2:1059.
A simple non-invasive stereotactic device for routine MR head examinations
Bourdette DN, Edmonds E, Smith C, Bowen JD, Guttmann CR, Nagy ZP, Simon J, Whitham R, Lovera J, Yadav V, Mass M, Spencer L, Culbertson N, Bartholomew RM, Theofan G, Milano J, Offner H, Vandenbark AA
A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis. Mult Scler. 2005 Oct; 11(5):552-61.
A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis.
Can MRI reveal phenotypes of multiple sclerosis? Magn Reson Imaging. 2006 May; 24(4):475-81.
Can MRI reveal phenotypes of multiple sclerosis?
Desikan RS, Cabral HJ, Fischl B, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ
Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):532-8.
Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease.
Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR
Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):234-7.
Rate of brain atrophy in benign vs early multiple sclerosis.
Kaplan RF, Cohen RA, Moscufo N, Guttmann C, Chasman J, Buttaro M, Hall CH, Wolfson L
Journal of clinical and experimental neuropsychology
Demographic and biological influences on cognitive reserve. J Clin Exp Neuropsychol. 2009 Oct; 31(7):868-76.
Demographic and biological influences on cognitive reserve.
A simple noninvasive stereotactic device for routine MR head examinations. J Comput Assist Tomogr. 1996 Jul-Aug; 20(4):588-91.
A simple noninvasive stereotactic device for routine MR head examinations.
Yoo SS, Guttmann CR, Ives JR, Panych LP, Kikinis R, Schomer DL, Jolesz FA
Electroencephalography and clinical neurophysiology
3D localization of surface 10-20 EEG electrodes on high resolution anatomical MR images. Electroencephalogr Clin Neurophysiol. 1997 Apr; 102(4):335-9.
3D localization of surface 10-20 EEG electrodes on high resolution anatomical MR images.
Liguori M, Meier DS, Hildenbrand P, Healy BC, Chitnis T, Baruch NF, Khoury SJ, Weiner HL, Bakshi R, Barkhof F, Guttmann CR
One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2011 Oct; 82(10):1125-31.
One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis.
N.Moscufo, I.Csapo, J.Schmidt, G.Pearlson, L.Wolfson, C.Guttmann
White Matter Hyperintensities (WMH's) in Mobility-Impaired Elderly. AAN Conference, Boston, MA. 2007.
White Matter Hyperintensities (WMH's) in Mobility-Impaired Elderly
Meier D.S., Weiner H.L., Guttmann C.R.G.
MS Repair Potential and Disease Progression from Short-Term T2 Change. Proceedings of 15th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2007; 15:2196.
MS Repair Potential and Disease Progression from Short-Term T2 Change
Single-slab three-dimensional spin-echo-based pulse sequences for high-resolution T1-weighted and T2- weighted imaging of the brain. International Society for Magnetic Resonance in Medicine. 1997; 1:137.
Single-slab three-dimensional spin-echo-based pulse sequences for high-resolution T1-weighted and T2- weighted imaging of the brain
Warfield SK, Westin C-F, Guttmann CRG, Albert M, Jolesz FA, Kikinis R Fractional segmentation of white matter. In: Taylor C, Colchester A, editors (Goos G, Hartmanis J, van Leeuwen J, editors, Lecture notes in computer science, vol. 1679). Proceedings of the 2nd International Conference on Medical Computing and Computer-Assisted Intervention (MICCAI); September 19-22, 1999, Cambridge, UK. Berlin: Springer; 1999. p. 62-71.
Cavallari M, Dai W, Guttmann CRG, Meier DS, Ngo LH, Hshieh TT, Fong TG, Schmitt E, Press DZ, Travison TG, Marcantonio ER, Jones RN, Inouye SK, Alsop DC
Longitudinal diffusion changes following postoperative delirium in older people without dementia. Neurology. 2017 Sep 05; 89(10):1020-1027.
Longitudinal diffusion changes following postoperative delirium in older people without dementia.
Cavallari M, Guttmann CRG, Inouye SK, Alsop DC
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
State of the Art and Promise of Structural Neuroimaging in Postoperative Delirium and Postoperative Cognitive Decline. Am J Geriatr Psychiatry. 2017 10; 25(10):1062-1063.
State of the Art and Promise of Structural Neuroimaging in Postoperative Delirium and Postoperative Cognitive Decline.
Milles J, Zhu YM, Chen N-K, Panych LP, Gimenez G, Guttmann CRG
MRI intensity nonuniformity correction using simultaneously spatial and gray-level histogram information. Medical Imaging 2004, Image Processing. 2004; 5370:734-42.
MRI intensity nonuniformity correction using simultaneously spatial and gray-level histogram information
Yoo SS, Wei X, Dickey CC, Guttmann CR, Panych LP
The International journal of neuroscience
Long-term reproducibility analysis of fMRI using hand motor task. Int J Neurosci. 2005 Jan; 115(1):55-77.
Long-term reproducibility analysis of fMRI using hand motor task.
Wu Y, Warfield SK, Tan IL, Wells WM, Meier DS, van Schijndel RA, Barkhof F, Guttmann CR
Automated segmentation of multiple sclerosis lesion subtypes with multichannel MRI. Neuroimage. 2006 Sep; 32(3):1205-15.
Automated segmentation of multiple sclerosis lesion subtypes with multichannel MRI.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential? Neurotherapeutics. 2007 Jul; 4(3):485-98.
Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential?
Holland CM, Charil A, Csapo I, Liptak Z, Ichise M, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR
The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):129-36.
The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis.
Versatile Stereotactic Device and Methods of Use
Versatile Stereotactic Device and Methods of Use. 2004.
Milles J, Zhu YM, Gimenez G, Guttmann CR, Magnin IE
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
MRI intensity nonuniformity correction using simultaneously spatial and gray-level histogram information. Comput Med Imaging Graph. 2007 Mar; 31(2):81-90.
MRI intensity nonuniformity correction using simultaneously spatial and gray-level histogram information.
Wei X, Yoo SS, Dickey CC, Zou KH, Guttmann CR, Panych LP
Functional MRI of auditory verbal working memory: long-term reproducibility analysis. Neuroimage. 2004 Mar; 21(3):1000-8.
Functional MRI of auditory verbal working memory: long-term reproducibility analysis.
A method for the analysis of the geometrical relationship between white matter pathology and the vascular architecture of the brain. Neuroimage. 2004 Aug; 22(4):1671-8.
A method for the analysis of the geometrical relationship between white matter pathology and the vascular architecture of the brain.
Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD. Neurology. 2008 Sep 09; 71(11):819-25.
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD.
Diaz-Cruz C, Chua AS, Malik MT, Kaplan T, Glanz BI, Egorova S, Guttmann CRG, Bakshi R, Weiner HL, Healy BC, Chitnis T
The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis. Mult Scler Relat Disord. 2017 Oct; 17:47-53.
The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis.
Horsfield MA, Bakshi R, Rovaris M, Rocca MA, Dandamudi VS, Valsasina P, Judica E, Lucchini F, Guttmann CR, Sormani MP, Filippi M
Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis. IEEE Trans Med Imaging. 2007 Dec; 26(12):1670-80.
Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis.
B. Moraal, D. S. Meier, H. Vrenken, P. A. Poppe, R. A. van Schijindel, P. J. Pouwels, C. R. Guttmann, F. Barkhof
Registration and subtraction of 2D-T2SE images in a routine multicentre multiple sclerosis (MS) trial setting. Proceedings of 14th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2006; 14:2107.
Registration and subtraction of 2D-T2SE images in a routine multicentre multiple sclerosis (MS) trial setting
Kikinis R, Metcalf D, Guttmann C, Gleason PL, Jolesz FA
Proceedings of the 31st annual meeting of the American Society of Neuroradiology
Quantitative analysis of the temporal development of MS lesion. Proceedings of the 31st annual meeting of the American Society of Neuroradiology. 1993; 255-256.
Quantitative analysis of the temporal development of MS lesion
Time-series analysis of MRI intensity patterns in multiple sclerosis. Neuroimage. 2003 Oct; 20(2):1193-209.
Time-series analysis of MRI intensity patterns in multiple sclerosis.
Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL
Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol. 2001 Jan; 58(1):115-21.
Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study.
Stankiewicz JM, Glanz BI, Healy BC, Arora A, Neema M, Benedict RH, Guss ZD, Tauhid S, Buckle GJ, Houtchens MK, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging. 2011 Apr; 21(2):e50-6.
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis.
Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR
Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage. 2011 Jan 15; 54(2):787-93.
Cognitive profile and brain morphological changes in obstructive sleep apnea.
Klein JP, Arora A, Neema M, Healy BC, Tauhid S, Goldberg-Zimring D, Chavarro-Nieto C, Stankiewicz JM, Cohen AB, Buckle GJ, Houtchens MK, Ceccarelli A, Dell'Oglio E, Guttmann CR, Alsop DC, Hackney DB, Bakshi R
A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1138-42.
A 3T MR imaging investigation of the topography of whole spinal cord atrophy in multiple sclerosis.
Prat A, Biernacki K, Saroli T, Orav JE, Guttmann CR, Weiner HL, Khoury SJ, Antel JP
Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. Arch Neurol. 2005 May; 62(5):795-800.
Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability.
Die Bedeutung von Proteasen fur das invasive Verhalten von Glioblastom Zellinien im zentralen Nervensystem
Die Bedeutung von Proteasen fur das invasive Verhalten von Glioblastom Zellinien im zentralen Nervensystem. 1989.
Building a probabilistic anatomical brain atlas for multiple sclerosis. International Society for Magnetic Resonance in Medicine. 2002; 10:2474.
Building a probabilistic anatomical brain atlas for multiple sclerosis
American National Multiple Sclerosis Society (NMSS)
"Now, more than ever. Progress in multiple sclerosis research"
"Now, more than ever. Progress in multiple sclerosis research". 1995.
M.Smith, R.Castellani, S.Napoli, G.Perry, C.Guttmann, U.De Girolami, R.Bakshi
Gray Matter Iron Deposition in Patients with MS: A Histo-Chemical Study. AAN Conference, Boston, MA. 2007.
Gray Matter Iron Deposition in Patients with MS: A Histo-Chemical Study
Gauthier SA, Mandel M, Guttmann CR, Glanz BI, Khoury SJ, Betensky RA, Weiner HL
Predicting short-term disability in multiple sclerosis. Neurology. 2007 Jun 12; 68(24):2059-65.
Predicting short-term disability in multiple sclerosis.
Moraal B, Roosendaal SD, Pouwels PJ, Vrenken H, van Schijndel RA, Meier DS, Guttmann CR, Geurts JJ, Barkhof F
Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis. Eur Radiol. 2008 Oct; 18(10):2311-20.
Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis.
Cavallari M, Egorova S, Healy BC, Palotai M, Prieto JC, Polgar-Turcsanyi M, Tauhid S, Anderson M, Glanz B, Chitnis T, Guttmann CRG
Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis. J Neuroimaging. 2018 05; 28(3):273-277.
Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis.
Meier DS, Guttmann CRG, Tummala S, Moscufo N, Cavallari M, Tauhid S, Bakshi R, Weiner HL
Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI. J Neuroimaging. 2018 01; 28(1):36-47.
Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI.
Liguori M, Healy BC, Glanz BI, Khoury SJ, Moscufo N, Weiner HL, De Jager PL, Guttmann CR
HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study. Genes Immun. 2011 Apr; 12(3):183-90.
HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study.
Bakshi R, Neema M, Healy BC, Liptak Z, Betensky RA, Buckle GJ, Gauthier SA, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury SJ, Guttmann CR, Weiner HL
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch Neurol. 2008 Nov; 65(11):1449-53.
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Moraal B, Meier DS, Poppe PA, Geurts JJ, Vrenken H, Jonker WM, Knol DL, van Schijndel RA, Pouwels PJ, Pohl C, Bauer L, Sandbrink R, Guttmann CR, Barkhof F
Subtraction MR images in a multiple sclerosis multicenter clinical trial setting. Radiology. 2009 Feb; 250(2):506-14.
Subtraction MR images in a multiple sclerosis multicenter clinical trial setting.
Kuchel GA, Moscufo N, Guttmann CR, Zeevi N, Wakefield D, Schmidt J, Dubeau CE, Wolfson L
Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2009 Aug; 64(8):902-9.
Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults.
Moraal B, van den Elskamp IJ, Knol DL, Uitdehaag BM, Geurts JJ, Vrenken H, Pouwels PJ, van Schijndel RA, Meier DS, Guttmann CR, Barkhof F
Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials. Ann Neurol. 2010 May; 67(5):667-75.
Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials.
Hannoun S, Durand-Dubief F, Confavreux C, Ibarrola D, Streichenberger N, Cotton F, Guttmann CR, Sappey-Marinier D
Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis. AJNR Am J Neuroradiol. 2012 Aug; 33(7):1363-8.
Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis.
Identification of abnormal brain configurations in multiple sclerosis. International Society for Magnetic Resonance in Medicine. 2002; 10:353.
Identification of abnormal brain configurations in multiple sclerosis
Mulkern RV, Zengingonul HV, Holtzman D, Guttmann CRG, Robertson RL, Kyriakos W, Jolesz FA, Maier SE
Multi-component apparent diffusion coefficients in human brain: grey/white matter differences and spin-lattice relaxation times. International Society for Magnetic Resonance in Medicine. 1999; 1806.
Multi-component apparent diffusion coefficients in human brain: grey/white matter differences and spin-lattice relaxation times
Metcalf D, Kikinis R, Guttmann C, Vaina L, Jolesz F
Proceedings of the 14th annual international conference of the IEEE-EMBS
4D connected component labelling applied to quantitative analysis of MS lesion temporal development. Proceedings of the 14th annual international conference of the IEEE-EMBS. 1992; 3:945-946.
4D connected component labelling applied to quantitative analysis of MS lesion temporal development
Predicting Interferon Beta/Glatiramer Acetate Treatment Failures in MS: Four Year Analysis of the CLIMB Study. AAN. 2005.
Guimond A., Westin C-F., Panych L.P., Guttmann C.R.G.
Deformable registration of DT-MRI data based on invariant tensor characteristics. Neuroimage. 2002; P10435.
Deformable registration of DT-MRI data based on invariant tensor characteristics
B. Moraal, D.S. Meier, H. Vrenken, P.A. Poppe, R.A van Schijndel, P.J.W. Pouwels, C.R.G. Guttmann, F. Barkhof
Registration and subtraction of 2D-T2SE images in a routine multi-centre multiple sclerosis trial setting . Multiple Sclerosis Clinical and Laboratory Research. ECTRIMS 2006. 2006; 12(Suppl 1):S180.
Registration and subtraction of 2D-T2SE images in a routine multi-centre multiple sclerosis trial setting
Feasibility of real-time event-related fMRI. International Society for Magnetic Resonance in Medicine. 2000; 832.
Feasibility of real-time event-related fMRI
Zhao L, Liptak Z, Chen N-K, Jolesz FA, Mugler JP III, Guttmann CR
Clinical Implementation and Evaluation of High Resolution 3DFSE Whole Brain T2W and FLAIR MR Imaging. International Society for Magnetic Resonance in Medicine. 2004.
Clinical Implementation and Evaluation of High Resolution 3DFSE Whole Brain T2W and FLAIR MR Imaging
Guttmann CRG, Weiner HL, Kikinis R, Hsu L, Ahn SS, Hohol MJ, Orav EJ, Khoury SJ, Hafler DA, Mackin GA, Jolesz FA
A prospective study of multiple sclerosis: correlation between MRI, clinical and immunological findings. Society of Magnetic Resonance. 1995; 2:1292.
A prospective study of multiple sclerosis: correlation between MRI, clinical and immunological findings
Gauthier SA, Glanz BI, Mandel M, Tsagkaropoulos A, Neema M, Stankiewicz J, Arora A, Duan Y, Liptak Z, Egorova S, Buckle GJ, Bakshi R, Guttmann CR, Khoury SJ, Weiner HL
Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. J Neurol Sci. 2009 Sep 15; 284(1-2):116-9.
Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study.
Mike A, Glanz BI, Hildenbrand P, Meier D, Bolden K, Liguori M, Dell'Oglio E, Healy BC, Bakshi R, Guttmann CR
Identification and clinical impact of multiple sclerosis cortical lesions as assessed by routine 3T MR imaging. AJNR Am J Neuroradiol. 2011 Mar; 32(3):515-21.
Identification and clinical impact of multiple sclerosis cortical lesions as assessed by routine 3T MR imaging.
Yoo S, Wei X, Dickey CC, Paralkar G, O’Leary HM, Guttmann CRG, Panych LP
Evaluation of reproducibility in sensorimotor activation: long-term fMRI study. International Society for Magnetic Resonance in Medicine. 2002; 10:1476.
Evaluation of reproducibility in sensorimotor activation: long-term fMRI study
Guttmann CRG, Warfield SK, Guimond A, Kikinis R, Jolesz FA, Weiner HL.
Discrimination of relapsing and progressive MS through MRI estimates of brain parenchymal fraction and lesion burden. Neurology. 2000; 54(Suppl):A18.
Discrimination of relapsing and progressive MS through MRI estimates of brain parenchymal fraction and lesion burden
Sperling RA, Wible CG, Yoo S-S, Guttmann CRG, Panych LP, Johnson KA, Nelson A, Kacher D, Wells W, Chabrerie A, Ozlen F, Stieg PE, Kikinis R, Jolesz FA
Integration of fMRI with intraoperative imaging techniques. 4th International Conference on Functional Mapping of the Human Brain. 1998; S455.
Integration of fMRI with intraoperative imaging techniques
Egorova E, Z Liptak , Liu L, Meier D, Chen N-K, Killiany RJ, Albert MS, Guttmann CRG
Proceedings of 13th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine
Accelerated brain parenchymal loss in healthy people above 60. Proceedings of 13th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2005; 761.
Duan Y., Tate D.F., Hildenbrand P.G., Csapo I., Meier D.S., Guttmann C.R.G.
Segmentation of Subtraction Images Yields Improvement in Reproducibility and Sensitivity of Lesion Change Measurements in MS. Proceedings of 15th Scientific Meeting and Exibition of the International Society for Magnetic Resonance in Medicine. 2007; 15:2064.
Segmentation of Subtraction Images Yields Improvement in Reproducibility and Sensitivity of Lesion Change Measurements in MS
Duan Y, Hildenbrand PG, Sampat MP, Tate DF, Csapo I, Moraal B, Bakshi R, Barkhof F, Meier DS, Guttmann CR
Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis. AJNR Am J Neuroradiol. 2008 Feb; 29(2):340-6.
Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis.
Wu Y, Warfield SK, Tan IL, Meier D, Wells WMIII, Wei XC, Van Schijndel RA, Barkhof F, Guttmann CRG
Segmentation of multiple lesion types in multiple sclerosis. International Society for Magnetic Resonance in Medicine. 2002; 10:2475.
Segmentation of multiple lesion types in multiple sclerosis
Palotai M, Mike A, Cavallari M, Strammer E, Orsi G, Healy BC, Schregel K, Illes Z, Guttmann CR
Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis. Mult Scler. 2018 07; 24(8):1105-1114.
Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis.
Tate DF, Sampat M, Harezlak J, Fiecas M, Hogan J, Dewey J, McCaffrey D, Branson D, Russell T, Conley J, Taylor M, Schifitto G, Schifitto G, Zhong J, Daar ES, Alger J, Brown M, Singer E, Campbell T, McMahon D, Tso Y, Matesan J, Letendre S, Paulose S, Gaugh M, Tripoli C, Yiannoutsos C, Bigler ED, Cohen RA, Guttmann CR, Navia B
Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol. 2011 Aug; 17(4):368-79.
Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.
Cotton F, Weiner HL, Jolesz FA, Guttmann CR
MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology. 2003 Feb 25; 60(4):640-6.
MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals.
Mulkern RV, Lilly HS, Meng J, Bowers J, Guttmann CRG, Oshio K, Williamson DS, Jaramillo D.
Assessing triglyceride unsaturation with a proton spectroscopic imaging method: in vivo and in vitro studies. Society of Magnetic Resonance. 1994; 1:176.
Assessing triglyceride unsaturation with a proton spectroscopic imaging method: in vivo and in vitro studies
Wolfson L, Wei X, Hall CB, Panzer V, Wakefield D, Benson RR, Schmidt JA, Warfield SK, Guttmann CR
Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility. J Neurol Sci. 2005 May 15; 232(1-2):23-7.
Accrual of MRI white matter abnormalities in elderly with normal and impaired mobility.
Laplaud DA, Berthelot L, Miqueu P, Bourcier K, Moynard J, Oudinet Y, Guillet M, Ruiz C, Oden N, Brouard S, Guttmann CR, Weiner HL, Khoury SJ, Soulillou JP
Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters. J Neuroimmunol. 2006 Aug; 177(1-2):151-60.
Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters.
Smith DR, Weinstock-Guttman B, Cohen JA, Wei X, Guttmann C, Bakshi R, Olek M, Stone L, Greenberg S, Stuart D, Orav J, Stuart W, Weiner H
A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta. Mult Scler. 2005; 11(5):573-82.
A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta
Bao S, Guttmann CR, Mugler JP, Brookeman JR, Panych LP, Kraft RA, Oshio K, Jaramillo D, Jolesz FA, Williamson DS, Mulkern RV
Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow. Magn Reson Imaging. 1999 Oct; 17(8):1203-10.
Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow.
Real-time adaptive functional MRI. Neuroimage. 1999 Nov; 10(5):596-606.
Wu Y, Wells WM III, Warfield S, Wei X, Li X, Anderson M, Guttmann CRG
Effect of gain field inhomogeneity correction on automated segmentation of the intracranial cavity. International Society for Magnetic Resonance in Medicine. 2001; 9:805.
Effect of gain field inhomogeneity correction on automated segmentation of the intracranial cavity
Hohol MJ, Guttmann CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL
Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch Neurol. 1997 Aug; 54(8):1018-25.
Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis.