Thomas B. Fitzpatrick Professor of Dermatology
Müller-Röver S, Rossiter H, Paus R, Handjiski B, Peters EM, Murphy JE, Mecklenburg L, Kupper TS
Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia. Am J Pathol. 2000 Apr; 156(4):1395-405.
Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.
Nambudiri VE, Watson AJ, Rubenstein MH, Kupper TS, Yang FC
Association of Patient Satisfaction With Medical Scribe Use in an Academic Dermatology Practice. JAMA Dermatol. 2018 04 01; 154(4):480-482.
Association of Patient Satisfaction With Medical Scribe Use in an Academic Dermatology Practice.
Gehad A, Teague JE, Matos TR, Huang V, Yang C, Watanabe R, O'Malley JT, Trimble CL, Kupper TS, Clark RA
A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018 02 13; 2(3):292-298.
A primary role for human central memory cells in tissue immunosurveillance.
Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME
Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992 Mar 20; 68(6):1051-60.
Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains.
Cytokines: IL-20 - a new effector in skin inflammation. Curr Biol. 2001 Jul 10; 11(13):R531-4.
Cytokines: IL-20 - a new effector in skin inflammation.
Cutaneous eruptions during GM-CSF infusion. Clues for cytokine biology. Arch Dermatol. 1991 Jan; 127(1):110-2.
Cutaneous eruptions during GM-CSF infusion. Clues for cytokine biology.
Mizutani H, Mizutani T, Okada H, Kupper TS, Shimizu M
Journal of the American Academy of Dermatology
Round fingerpad sign: an early sign of scleroderma. J Am Acad Dermatol. 1991 Jan; 24(1):67-9.
Round fingerpad sign: an early sign of scleroderma.
Groves RG, Sherman L, Dower S, Kupper TS.
Localization of functional IL-1 receptors in human skin: increased expression after organ culture and in psoriasis. Am J. Path. 1994; 145:1048-1056.
Localization of functional IL-1 receptors in human skin: increased expression after organ culture and in psoriasis
Dermatology in General Medicine, T. Fitzpatrick et al, Ed
Cytokines and Chemokines. Dermatology in General Medicine, T. Fitzpatrick et al, Ed. 1999.
Journal of immunology (Baltimore, Md. : 1950)
Immunoregulation after thermal injury: sequential appearance of I-J+, Ly-1 T suppressor inducer cells and Ly-2 T suppressor effector cells following thermal trauma in mice. J Immunol. 1984 Dec; 133(6):3047-53.
Immunoregulation after thermal injury: sequential appearance of I-J+, Ly-1 T suppressor inducer cells and Ly-2 T suppressor effector cells following thermal trauma in mice.
Alon R, Rossiter H, Wang X, Springer TA, Kupper TS
Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. J Cell Biol. 1994 Dec; 127(5):1485-95.
Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.
Mizutani H, Roswit W, Hemperly J, Lawley T, Compton C, Swerlick R, Kupper TS
Biochemical and biophysical research communications
Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule. Biochem Biophys Res Commun. 1994 Aug 30; 203(1):686-93.
Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule.
Proceedings of the National Academy of Sciences of the United States of America
Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5814-9.
Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation.
Dubin DB, Hurowitz JC, Brettler D, Bernhard JD, Kadin ME, Wallace JE, Woda B, Pihan G, Kupper TS, Harrist TJ
Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome. J Am Acad Dermatol. 1998 Mar; 38(3):493-7.
Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome.
Yamanaka K, Tanaka M, Tsutsui H, Kupper TS, Asahi K, Okamura H, Nakanishi K, Suzuki M, Kayagaki N, Black RA, Miller DK, Nakashima K, Shimizu M, Mizutani H
Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol. 2000 Jul 15; 165(2):997-1003.
Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18.
Burkhardt M, Kupper T, Hean S, Haag R, Schmid P, Kohler M, Boller M
Water science and technology : a journal of the International Association on Water Pollution Research
Biocides used in building materials and their leaching behavior to sewer systems. Water Sci Technol. 2007; 56(12):63-7.
Biocides used in building materials and their leaching behavior to sewer systems.
Emissions of OTNE (Iso-E-super) - mass flows in sewage treatment plants. Chemosphere. 2008 May; 71(11):2003-10.
Emissions of OTNE (Iso-E-super) - mass flows in sewage treatment plants.
Cheaib Z, Grandjean D, Kupper T, de Alencastro LF
Bulletin of environmental contamination and toxicology
Brominated flame retardants in fish of Lake Geneva (Switzerland). Bull Environ Contam Toxicol. 2009 Apr; 82(4):522-7.
Brominated flame retardants in fish of Lake Geneva (Switzerland).
Baker CC, Niven-Fairchild T, Caragnano C, Kupper TS
Outcome following femur fracture and subsequent cecal ligation and puncture in endotoxin-sensitive (C3H/HeN) and endotoxin-resistant (C3H/HeJ) mice. J Surg Res. 1991 Feb; 50(2):170-4.
Outcome following femur fracture and subsequent cecal ligation and puncture in endotoxin-sensitive (C3H/HeN) and endotoxin-resistant (C3H/HeJ) mice.
Goddard DS, Yamanaka K, Kupper TS, Jones DA
Clinical cancer research : an official journal of the American Association for Cancer Research
Activation of neutrophils in cutaneous T-cell lymphoma. Clin Cancer Res. 2005 Dec 01; 11(23):8243-9.
Activation of neutrophils in cutaneous T-cell lymphoma.
Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7443-8.
Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.
Principles of Molecular Medicine, L Jameson, Ed
DERMATOLOGY. Principles of Molecular Medicine, L Jameson, Ed. 1998.
The human burn wound as a primary source of interleukin-1 activity. Surgery. 1986 Aug; 100(2):409-15.
The human burn wound as a primary source of interleukin-1 activity.
Stephan RN, Kupper TS, Geha AS, Baue AE, Chaudry IH
Archives of surgery (Chicago, Ill. : 1960)
Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg. 1987 Jan; 122(1):62-8.
Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis.
Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin. J Immunol. 1993 Feb 15; 150(4):1172-82.
Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.
de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS
High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 05 09; 10(440).
High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides.
Misbehaving macrophages in the pathogenesis of psoriasis. J Clin Invest. 2006 Aug; 116(8):2084-7.
Misbehaving macrophages in the pathogenesis of psoriasis.
Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS
The Journal of allergy and clinical immunology
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. J Allergy Clin Immunol. 2008 Jan; 121(1):148-157.e3.
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
Kupper TS, Horowitz M, Birchall N, Mizutani H, Coleman D, McGuire J, Flood P, Dower S, Lee F
Annals of the New York Academy of Sciences
Hematopoietic, lymphopoietic, and proinflammatory cytokines produced by human and murine keratinocytes. Ann N Y Acad Sci. 1988; 548:262-70.
Hematopoietic, lymphopoietic, and proinflammatory cytokines produced by human and murine keratinocytes.
Campbell JJ, Clark RA, Watanabe R, Kupper TS
Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010 Aug 05; 116(5):767-71.
Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors.
Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC
The Journal of investigative dermatology
Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34.
Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection.
Keratinocyte membrane-associated epidermal cell-derived thymocyte-activating factor (ETAF). J Invest Dermatol. 1987 Jan; 88(1):97-100.
Keratinocyte membrane-associated epidermal cell-derived thymocyte-activating factor (ETAF).
Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84.
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells.
Plagellat C, Kupper T, de Alencastro LF, Grandjean D, Tarradellas J
Biocides in sewage sludge: quantitative determination in some Swiss wastewater treatment plants. Bull Environ Contam Toxicol. 2004 Nov; 73(5):794-801.
Biocides in sewage sludge: quantitative determination in some Swiss wastewater treatment plants.
Frieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH
A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study. Arch Dermatol. 2000 Feb; 136(2):179-84.
A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study.
The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression. Exp Dermatol. 2012 Dec; 21(12):964-6.
The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression.
Selectins, T-cell rolling andn inflammation. Mol Med Today. Review. 1997; 3(5):214-22.
Selectins, T-cell rolling andn inflammation
Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines. J Cutan Pathol. 1993 Feb; 20(1):21-7.
Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines.
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells. Front Immunol. 2018; 9:1347.
Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells.
Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W
Interleukin-16 as a marker of Sézary syndrome onset and stage. J Clin Immunol. 2011 Feb; 31(1):39-50.
Interleukin-16 as a marker of Sézary syndrome onset and stage.
Kupper TS, Lee F, Flood P, Horowitz M, Coleman D
Hematopoietic cytokines produced by murine and human keratinocytes. Ann. NY. Acad. Sci. 1988; 548:283.
Hematopoietic cytokines produced by murine and human keratinocytes
Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS
Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol. 2005 Jun; 79(12):7363-70.
Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion.
Kupper T, Bucheli TD, Brändli RC, Ortelli D, Edder P
Dissipation of pesticides during composting and anaerobic digestion of source-separated organic waste at full-scale plants. Bioresour Technol. 2008 Nov; 99(17):7988-94.
Dissipation of pesticides during composting and anaerobic digestion of source-separated organic waste at full-scale plants.
Horowitz MC, Coleman DL, Flood PM, Kupper TS, Jilka RL
Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor. J Clin Invest. 1989 Jan; 83(1):149-57.
Parathyroid hormone and lipopolysaccharide induce murine osteoblast-like cells to secrete a cytokine indistinguishable from granulocyte-macrophage colony-stimulating factor.
Galy AH, Dinarello CA, Kupper TS, Kameda A, Hadden JW
Effects of cytokines on human thymic epithelial cells in culture. II. Recombinant IL 1 stimulates thymic epithelial cells to produce IL6 and GM-CSF. Cell Immunol. 1990 Aug; 129(1):161-75.
Effects of cytokines on human thymic epithelial cells in culture. II. Recombinant IL 1 stimulates thymic epithelial cells to produce IL6 and GM-CSF.
Jacobson B, Kupper TS, Baker CC, Cuono C.
The effect of immediate excision and autografting of allografting on immune responses after burn injury. J. Burn Care Rehab. 1988; 9:354.
The effect of immediate excision and autografting of allografting on immune responses after burn injury
Kupper TS, Chua AO, Flood P, McGuire J, Gubler U
Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest. 1987 Aug; 80(2):430-6.
Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.
Black R, Kronheim S, Sleath P, Greenstreet T, Vica GD, March C, Kupper TS.
The protelolyctic activation of interleukin-1 beta. Agents and Actions. 1991; 35:85-9.
The protelolyctic activation of interleukin-1 beta
Mechanisms of cutaneous inflammation. Interactions between epidermal cytokines, adhesion molecules, and leukocytes. Arch Dermatol. 1989 Oct; 125(10):1406-12.
Mechanisms of cutaneous inflammation. Interactions between epidermal cytokines, adhesion molecules, and leukocytes.
Kupper T, Flood P, Coleman D, Horowitz M
Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). J Immunol. 1987 Jun 15; 138(12):4288-92.
Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF).
Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53.
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.
Studies on the induction and reversal of depressed immunity following burn injury.
Studies on the induction and reversal of depressed immunity following burn injury. 1981.
Studies on the induction and reversal of depressed immunity following burn injury
McGuire J, Birchall N, Langdon B, Kupper TS.
Regulation of interleukin 1 mRNA in keratinocytes by glucocorticosteroids. Ann. NY. Acad. Sci. 1988; 548:283.
Regulation of interleukin 1 mRNA in keratinocytes by glucocorticosteroids
van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. Pigment Cell Melanoma Res. 2010 Jun; 23(3):375-84.
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi.
Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Feb 29; 483(7388):227-31.
Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.
Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE
Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulation. Arch Surg. 1986 Sep; 121(9):1000-5.
Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulation.
Mycosis fungoides presenting at the site of a transdermal estradiol patch. J Am Acad Dermatol. 2012 Nov; 67(5):e207-8.
Mycosis fungoides presenting at the site of a transdermal estradiol patch.
Mechanisms of cutaneous inflammation. Interactions between epidermal cytokins, adhesion molecules, and leukocytes. Ach Dermatol. 1989; 125(10):1406-12.
Mechanisms of cutaneous inflammation. Interactions between epidermal cytokins, adhesion molecules, and leukocytes
In Epidermal Growth Factors and Cytokines, T. Luger and T. Schwartz, Eds
The second decade of epidermal cytokins: an overview. In Epidermal Growth Factors and Cytokines, T. Luger and T. Schwartz, Eds. 1993.
The second decade of epidermal cytokins: an overview
Kupper TS, Coleman DL, McGuire J, Goldminz D, Horowitz MC
Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4451-5.
Keratinocyte-derived T-cell growth factor: a T-cell growth factor functionally distinct from interleukin 2.
Yamanaka K, Clark R, Rich B, Dowgiert R, Hirahara K, Hurwitz D, Shibata M, Mirchandani N, Jones DA, Goddard DS, Eapen S, Mizutani H, Kupper TS
Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma. Blood. 2006 Mar 15; 107(6):2440-5.
Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma.
Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS
A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol. 2006 May; 126(5):1059-70.
A novel method for the isolation of skin resident T cells from normal and diseased human skin.
The Immunophysiology of Cells and Cytokines, E. Shevach and J. Oppenheim, Ed
"The Role of Epidermal Cytokines". The Immunophysiology of Cells and Cytokines, E. Shevach and J. Oppenheim, Ed. 1990.
Groves RW, Giri J, Sims J, Dower SK, Kupper TS
Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis. J Immunol. 1995 Apr 15; 154(8):4065-72.
Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.
Immunity at the surface: homeostatic mechanisms of the skin immune system. Life Sci. 1996; 58(18):1485-507.
Immunity at the surface: homeostatic mechanisms of the skin immune system.
Mizutani H, May LT, Sehgal PB, Kupper TS
Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6. J Immunol. 1989 Aug 01; 143(3):896-901.
Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6.
Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS
Laboratory investigation; a journal of technical methods and pathology
T-cell trafficking plays an essential role in tumor immunity. Lab Invest. 2019 01; 99(1):85-92.
T-cell trafficking plays an essential role in tumor immunity.
Clark RA, Watanabe R, Teague JE, Schlapbach C, Tawa MC, Adams N, Dorosario AA, Chaney KS, Cutler CS, Leboeuf NR, Carter JB, Fisher DC, Kupper TS
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med. 2012 Jan 18; 4(117):117ra7.
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.
Groves RW, Mizutani H, Kieffer JD, Kupper TS
Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11874-8.
Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.
Immunity at the surface: homeostatic mechanisms of the skin immune system. Life Sci. Review. 1996; 58(18):1485-507.
Immunity at the surface: homeostatic mechanisms of the skin immune system
Inflammatory skin disease, T cells, and immune surveillance. N Engl J Med. Review. 1999; 9;341(24):1817-28.
Inflammatory skin disease, T cells, and immune surveillance
Kupper TS, Baker CC, Ferguson TA, Green DR
A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection. J Surg Res. 1985 Jun; 38(6):606-12.
A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection.
Kopp T, Lenz P, Bello-Fernandez C, Kastelein RA, Kupper TS, Stingl G
IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J Immunol. 2003 Jun 01; 170(11):5438-44.
IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity.
Jones DA, Yawalkar N, Suh KY, Sadat S, Rich B, Kupper TS
Identification of autoantigens in psoriatic plaques using expression cloning. J Invest Dermatol. 2004 Jul; 123(1):93-100.
Identification of autoantigens in psoriatic plaques using expression cloning.
Mee JB, Antonopoulos C, Poole S, Kupper TS, Groves RW
Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes. J Invest Dermatol. 2005 Jun; 124(6):1267-74.
Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes.
Hematology/oncology clinics of North America
Mycosis Fungoides and Sézary Syndrome: An Update. Hematol Oncol Clin North Am. 2019 02; 33(1):103-120.
Mycosis Fungoides and Sézary Syndrome: An Update.
Figueiredo ML, Dayan S, Kim Y, McBride J, Kupper TS, Wong DT
Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo. Mol Reprod Dev. 2006 Aug; 73(8):987-97.
Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo.
Adhesion molecules in scleroderma: collagen binding integrins. Int Rev Immunol. 1995; 12(2-4):217-25.
Adhesion molecules in scleroderma: collagen binding integrins.
Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12780-4.
Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens.
Reversal of postburn immunosuppression by the administration of vitamin A. Surgery. 1984 Aug; 96(2):330-5.
Reversal of postburn immunosuppression by the administration of vitamin A.
Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS
Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14; 217(2):466-74.
Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro.
Kupper T, Berset JD, Etter-Holzer R, Furrer R, Tarradellas J
Concentrations and specific loads of polycyclic musks in sewage sludge originating from a monitoring network in Switzerland. Chemosphere. 2004 Feb; 54(8):1111-20.
Concentrations and specific loads of polycyclic musks in sewage sludge originating from a monitoring network in Switzerland.
Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA
Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85.
Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin.
Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 01; 30(25):e233-6.
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma.
Ayehunie S, Bruzzese AM, Groves RW, Kupper TS, Langhoff E.
HIV-1 transmission by mucosal langerhans cells, blood dendritic cells, and monocytes in vitro. Reg. Immunol. 1994; 6:1-7.
HIV-1 transmission by mucosal langerhans cells, blood dendritic cells, and monocytes in vitro
Interleukin 1 and other human keratinocyte cytokines: molecular and functional characterization. Adv Dermatol. 1988; 3:293-307.
Interleukin 1 and other human keratinocyte cytokines: molecular and functional characterization.
Kupper TS, Lee F, Coleman D, Chodakewitz J, Flood P, Horowitz M
Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF). J Invest Dermatol. 1988 Aug; 91(2):185-8.
Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF).
Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 02; 566(7743):259-263.
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
T cells and the skin: from protective immunity to inflammatory skin disorders. Nat Rev Immunol. 2019 08; 19(8):490-502.
T cells and the skin: from protective immunity to inflammatory skin disorders.
Dorothy and Milton Flier Professor of Biomedical Science and Genetics
Jack, Sadie and David Breakstone Professor of Neurology, Emeritus
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 May; 569(7758):E12.
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
Martin C. Mihm, Jr., MD and Shing-Yiu Yip Professor of Dermatology
Samuel L. Wasserstrom Professor of Neurology
Lecturer on Biological Chemistry and Molecular Pharmacology
Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem. Clin Cancer Res. 2019 12 15; 25(24):7272-7274.
Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem.
O'Malley JT, de Masson A, Lowry EL, Giobbie-Hurder A, LeBoeuf NR, Larocca C, Gehad A, Seger E, Teague JE, Fisher DC, Kupper TS, Devlin PM, Clark RA
Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides. Clin Cancer Res. 2020 01 15; 26(2):408-418.
Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides.
Tian T, Lofftus S, Pan Y, Stingley CA, King SL, Zhao J, Pan TY, Lock R, Marglous JW, Liu K, Widlund HR, Fuhlbrigge RC, Cichowski K, Kupper TS
IL1a Antagonizes IL1ß and Promotes Adaptive Immune Rejection of Malignant Tumors. Cancer Immunol Res. 2020 05; 8(5):660-671.
IL1a Antagonizes IL1ß and Promotes Adaptive Immune Rejection of Malignant Tumors.
Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O'Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest. 2020 09 01; 130(9):4624-4636.
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease.
Lee J, Kim B, Chu H, Zhang K, Kim H, Kim JH, Kim SH, Pan Y, Noh JY, Sun Z, Lee J, Jeong KY, Park KH, Park JW, Kupper TS, Park CO, Lee KH
FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples. EBioMedicine. 2020 Aug; 58:102879.
FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples.
Advances in experimental medicine and biology
Resident Memory T Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020; 1273:39-68.
Resident Memory T Cells in the Tumor Microenvironment.
Pruessmann W, Rytlewski J, Wilmott J, Mihm MC, Attrill GH, Dyring-Andersen B, Fields P, Zhan Q, Colebatch AJ, Ferguson PM, Thompson JF, Kallenbach K, Yusko E, Clark RA, Robins H, Scolyer RA, Kupper TS
Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nat Cancer. 2020 02; 1(2):197-209.
Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence.
Pan Y, Liu L, Tian T, Zhao J, Park CO, Lofftus SY, Stingley CA, Yan Y, Mei S, Liu X, Kupper TS
Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge. NPJ Vaccines. 2021 Jan 04; 6(1):1.
Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge.
Sun Z, Kim JH, Kim SH, Kim HR, Zhang K, Pan Y, Ko MK, Kim BM, Chu H, Lee HR, Kim HL, Kim JH, Fu X, Hyun YM, Yun KN, Kim JY, Lee DW, Song SY, Lin CP, Clark RA, Lee KH, Kupper TS, Park CO
Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis. J Allergy Clin Immunol. 2021 05; 147(5):1764-1777.
Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis.
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 02; 602(7897):496-502.
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.
Yu KK, Smith NP, Essien SV, Teague JE, Vieyra-Garcia P, Gehad A, Zhan Q, Crouch JD, Gerard N, Larocca C, Wolf P, LeBoeuf NR, Tawa M, Kupper TS, Villani AC, Clark RA
IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell Lymphoma. J Invest Dermatol. 2022 08; 142(8):2285-2288.e2.
IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell Lymphoma.
Publisher Correction: Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nat Cancer. 2020 04; 1(4):470.
Publisher Correction: Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence.
Giustiniani J, Dobos G, Moins-Teisserenc H, Eustaquio T, Battistella M, Ortonne N, Ram-Wolff C, Bouaziz JD, Marie-Cardine A, Mourah S, Bagot M, Kupper TS, Clark RA, Bensussan A, de Masson A
CCR8 is a new therapeutic target in cutaneous T-cell lymphomas. Blood Adv. 2022 06 14; 6(11):3507-3512.
CCR8 is a new therapeutic target in cutaneous T-cell lymphomas.
van Santen S, Zoutman WH, de Masson A, Quint KD, Willemze R, Gerard N, Teague JE, Kupper TS, Clark RA, Tensen CP, Vermeer MH
Tumor Clone Frequency Calculation Using High-Throughput Sequencing of the TCRß Gene in Patients with Folliculotropic Mycosis Fungoides. J Invest Dermatol. 2022 09; 142(9):2544-2546.e2.
Tumor Clone Frequency Calculation Using High-Throughput Sequencing of the TCRß Gene in Patients with Folliculotropic Mycosis Fungoides.
Said JT, Elman SA, Tawa M, Fisher DC, Merola JF, Kupper TS
Topical tofacitinib for the management of lymphocytic-variant hypereosinophilic syndrome with cutaneous involvement. Dermatol Ther. 2022 07; 35(7):e15518.
Topical tofacitinib for the management of lymphocytic-variant hypereosinophilic syndrome with cutaneous involvement.
Matos TR, Gehad A, Teague JE, Dyring-Andersen B, Benezeder T, Dowlatshahi M, Crouch J, Watanabe Y, O'Malley JT, Kupper TS, Yang C, Watanabe R, Clark RA
Central memory T cells are the most effective precursors of resident memory T cells in human skin. Sci Immunol. 2022 04 22; 7(70):eabn1889.
Central memory T cells are the most effective precursors of resident memory T cells in human skin.
Plumptre IR, Said JT, Sun T, Larocca C, Virgen CA, Kupper TS, Fisher DC, Devlin PM, Elco CP, Song JS, LeBoeuf NR
Clinical features and treatment outcomes for primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: a retrospective cohort study from the Dana-Farber Cancer Institute and updated literature review. Leuk Lymphoma. 2022 12; 63(12):2832-2846.
Clinical features and treatment outcomes for primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: a retrospective cohort study from the Dana-Farber Cancer Institute and updated literature review.
Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 Aug; 608(7923):E28.
Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.
Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, Mucciarone K, Heppt MV, Geddes-Sweeney J, Stewart K, Brandenburg A, Liang J, Dimitroff CJ, Mihm MC, Landsberg J, Schlapbach C, Lian CG, Murphy GF, Kupper TS, Ramsey MR, Barthel SR
Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis. Cancer Res. 2022 10 17; 82(20):3774-3784.
Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis.
In Memoriam-Martin C. Mihm, Jr. Dermatopathology (Basel). 2022 Sep 08; 9(3):304-306.
Virgen CA, Sparks JA, Nohria A, O'Hare MJ, Goyal A, Said JT, Tawa M, LeBoeuf NR, Kupper TS, Fisher DC, Larocca C
Mogamulizumab-Associated Myositis With and Without Myasthenia Gravis and/or Myocarditis in Patients With T-Cell Lymphoma. Oncologist. 2023 08 03; 28(8):e694-e698.
Mogamulizumab-Associated Myositis With and Without Myasthenia Gravis and/or Myocarditis in Patients With T-Cell Lymphoma.
Assessing the generation of tissue resident memory T cells by vaccines. Nat Rev Immunol. 2023 10; 23(10):655-665.
Assessing the generation of tissue resident memory T cells by vaccines.
Jfri A, Virgen CA, Tawa M, Giobbie-Hurder A, Kupper TS, Fisher DC, LeBoeuf NR, Larocca C
Prevalence and implications of mogamulizumab-induced immune-related adverse events in mycosis fungoides/Sézary syndrome; a single-center experience. J Am Acad Dermatol. 2023 Nov; 89(5):1044-1047.
Prevalence and implications of mogamulizumab-induced immune-related adverse events in mycosis fungoides/Sézary syndrome; a single-center experience.
Yu Z, Vieyra-Garcia P, Benezeder T, Crouch JD, Kim IR, O'Malley JT, Devlin PM, Gehad A, Zhan Q, Gudjonsson JE, Sarkar MK, Kahlenberg JM, Gerard N, Teague JE, Kupper TS, LeBoeuf NR, Larocca C, Tawa M, Pomahac B, Talbot SG, Orgill DP, Wolf P, Clark RA
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides. J Invest Dermatol. 2024 03; 144(3):621-632.e1.
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides.
Smith NP, Yan Y, Pan Y, Williams JB, Manakongtreecheep K, Pant S, Zhao J, Tian T, Pan T, Stingley C, Wu K, Zhang J, Kley AL, Sorger PK, Villani AC, Kupper TS
bioRxiv : the preprint server for biology
Resident memory T cell development is associated with AP-1 transcription factor upregulation across anatomical niches. bioRxiv. 2023 Oct 02.
Resident memory T cell development is associated with AP-1 transcription factor upregulation across anatomical niches.
Using the IL-1R1 and its ligands to optimize the T cell immune response to cancer
Gandham AR, Geller S, Dusza SW, Kupper TS, Myskowski PL
Racial Disparities in Mycosis Fungoides/Sézary Syndrome-A Single-Center Observational Study of 292 Patients. Clin Lymphoma Myeloma Leuk. 2024 04; 24(4):e174-e180.
Racial Disparities in Mycosis Fungoides/Sézary Syndrome-A Single-Center Observational Study of 292 Patients.
Skin vaccination and generation of protective lung-tropic memory T cells
Williams JF, Lucas FM, Carrasco RD, Lovitch SB, Fisher DC, Kupper TS, Sadigh S
Primary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting. J Cutan Pathol. 2024 Oct; 51(10):777-782.
Primary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting.
DeSimone JA, Guenova E, Carter JB, Chaney KS, Aldridge JR, Noell CM, Dorosario AA, Hansen JL, Kupper TS, Devlin PM
Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma. J Am Acad Dermatol. 2013 Jul; 69(1):61-5.
Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.
Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA
TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res. 2013 Jul 15; 19(14):3755-63.
TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.
Cabrera-Perez JS, Carey VJ, Odejide OO, Singh S, Kupper TS, Pillai SS, Weiss ST, Akenroye A
Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy. J Allergy Clin Immunol. 2025 May; 155(5):1584-1594.
Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy.
Characterizing the Conformation of Beta1 Integrins on Resident Memory T Cells in the Skin
Vander Lugt B, Tubo NJ, Nizza ST, Boes M, Malissen B, Fuhlbrigge RC, Kupper TS, Campbell JJ
CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes. J Immunol. 2013 Sep 15; 191(6):3119-27.
CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.
Hu L, Haynes H, Ferrazza D, Kupper T, Qureshi A
Impact of specialist consultations on inpatient admissions for dermatology-specific and related DRGs. J Gen Intern Med. 2013 Nov; 28(11):1477-82.
Impact of specialist consultations on inpatient admissions for dermatology-specific and related DRGs.
Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus. J Invest Dermatol. 2014 Mar; 134(3):686-694.
Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus.
Li WQ, Han J, Widlund HR, Correll M, Wang YE, Quackenbush J, Mihm MC, Canales AL, Wu S, Golub T, Hoshida Y, Hunter DJ, Murphy G, Kupper TS, Qureshi AA
CXCR4 pathway associated with family history of melanoma. Cancer Causes Control. 2014 Jan; 25(1):125-32.
CXCR4 pathway associated with family history of melanoma.
Larocca C, Bui AN, O'Malley JT, Giobbie-Hurder A, Tawa M, Teague JE, Clark RA, Cutler C, Jacobsen E, Fisher DC, Kupper TS, LeBoeuf NR
Long-term outcomes and clinical phenotypes associated with best response to low dose alemtuzumab in cutaneous T-cell lymphoma. Blood Cancer J. 2025 Apr 17; 15(1):69.
Long-term outcomes and clinical phenotypes associated with best response to low dose alemtuzumab in cutaneous T-cell lymphoma.
Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med. 2014 Jan 15; 6(219):219ra8.
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.
Hillebrandt D, Gurtoo A, Kupper T, Richards P, Schöffl V, Shah P, van der Spek R, Wallis N, Milledge J
UIAA Medical Commission Recommendations for Mountaineers, Hillwalkers, Trekkers, and Rock and Ice Climbers with Diabetes. High Alt Med Biol. 2023 06; 24(2):110-126.
UIAA Medical Commission Recommendations for Mountaineers, Hillwalkers, Trekkers, and Rock and Ice Climbers with Diabetes.
Burren A, Terranova M, Kreuzer M, Kupper T, Probst S
The relationship between milk urea nitrogen content and urinary nitrogen excretion as determined in 4 Swiss dairy breeds. J Dairy Sci. 2025 May; 108(5):5342-5360.
The relationship between milk urea nitrogen content and urinary nitrogen excretion as determined in 4 Swiss dairy breeds.
Smith NP, Yan Y, Pan Y, Williams JB, Manakongtreecheep K, Pant SM, Zhao J, Tian T, Pan T, Stingley C, Wu K, Zhang J, Kley AL, Sorger PK, Villani AC, Kupper TS
Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells. JCI Insight. 2025 Jun 23; 10(12).
Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells.
Devi KSP, Wang E, Jaiswal A, Konieczny P, Kim TG, Nirschl CJ, Verma A, Liu Y, Milczanowski J, Christo SN, Gandolfo LC, Haitz K, Vardam TD, Wu P, King SL, Tse SW, Pradhan K, Jiang X, Tian T, Fuhlbrigge RC, Schmults CD, Clark RA, Kupper TS, Freeman GJ, Mackay LK, Naik S, Newell EW, Elemento O, Suarez-Farinas M, Anandasabapathy N
PD-1 is requisite for skin TRM cell formation and specification by TGFß. Nat Immunol. 2025 Aug; 26(8):1339-1351.
PD-1 is requisite for skin TRM cell formation and specification by TGFß.
Kim DY, Dang TM, Huang JT, Stephen S, Kupper TS, Larocca C, LeBoeuf NR
Increasing incidence of cutaneous T-cell lymphoma among children and young adults in the United States, 1997-2019: A national poplation-based study using the National Childhood Cancer Registry. J Am Acad Dermatol. 2026 Feb 11.
Increasing incidence of cutaneous T-cell lymphoma among children and young adults in the United States, 1997-2019: A national poplation-based study using the National Childhood Cancer Registry.
Groenestein CM, Hutchings NJ, Haenel HD, Amon B, Menzi H, Mikkelsen MH, Misselbrook TH, van Bruggen C, Kupper T, Webb J
Comparison of ammonia emissions related to nitrogen use efficiency of livestock production in Europe. J Clean Prod. 2019 Feb 20; 211:1162-1170.
Comparison of ammonia emissions related to nitrogen use efficiency of livestock production in Europe.
Advising travellers beyond infectious diseases: Can we learn from our forebears? J Travel Med. 2022 08 20; 29(5).
Advising travellers beyond infectious diseases: Can we learn from our forebears?
Kupper T, Eugster R, Sintermann J, Neftel A, Häni C
A novel approach to estimate the abatement of ammonia emissions from mitigation techniques at farm-scale slurry stores exemplified by a semifloating cover. J Environ Qual. 2021 Sep; 50(5):1074-1083.
A novel approach to estimate the abatement of ammonia emissions from mitigation techniques at farm-scale slurry stores exemplified by a semifloating cover.
Valach AC, Häni C, Bühler M, Mohn J, Schrade S, Kupper T
Journal of the Air & Waste Management Association (1995)
Ammonia emissions from a dairy housing and wastewater treatment plant quantified with an inverse dispersion method accounting for deposition loss. J Air Waste Manag Assoc. 2023 12; 73(12):930-950.
Ammonia emissions from a dairy housing and wastewater treatment plant quantified with an inverse dispersion method accounting for deposition loss.
Wechselberger V, Hrad M, Bühler M, Kupper T, Spangl B, Fredenslund AM, Huber-Humer M, Scheutz C
Assessment of whole-site methane emissions from anaerobic digestion plants: Towards establishing emission factors for various plant configurations. Waste Manag. 2025 Jan 01; 191:253-263.
Assessment of whole-site methane emissions from anaerobic digestion plants: Towards establishing emission factors for various plant configurations.
Zhang K, Kim SM, Kwon HK, Kim SH, Kim TG, Sun Z, Kim HL, Tyo A, Kim JH, Kim RW, Kim JH, Choi JM, Park KM, Kim LK, Sohn MH, Park JW, Lee KH, Kupper TS, Park CO
Peripherally induced ROR?t+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy. Sci Transl Med. 2025 May 28; 17(800):eado1375.
Peripherally induced ROR?t+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy.
Fischer GM, Tsai HK, Huang J, Mochel MC, Sadigh S, Pan Z, Montesion M, Williams EA, Sabbagh M, Chetta P, Lip V, Ferry JA, Reimann JDR, Duncan L, Chen S, Kupper T, Liang MG, Vrooman LM, Pollard J, Pouli D, Fleming MD, Schmidt B, Harris MH, Bledsoe JR
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Genomic Profiling of Pediatric Mycosis Fungoides, Lymphomatoid Papulosis, and Primary Cutaneous Anaplastic Large Cell Lymphoma Identifies Recurrent Tyrosine Kinase Gene Fusions. Mod Pathol. 2025 Dec; 38(12):100908.
Genomic Profiling of Pediatric Mycosis Fungoides, Lymphomatoid Papulosis, and Primary Cutaneous Anaplastic Large Cell Lymphoma Identifies Recurrent Tyrosine Kinase Gene Fusions.
Williams JB, Pant SM, Kley AL, Rajmalani BA, Yapp C, Zhang J, Deans K, Rotrosen E, Sales A, Soger PK, Kupper TS
Regulatory T cells inhibit CD8+ TRM-like cells during the early stages of tumor immune escape. bioRxiv. 2025 Oct 22.
Regulatory T cells inhibit CD8+ TRM-like cells during the early stages of tumor immune escape.
Watanabe R, Teague JE, Fisher DC, Kupper TS, Clark RA
Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission. JAMA Dermatol. 2014 Jul; 150(7):776-9.
Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission.
Litvinov IV, Cordeiro B, Huang Y, Zargham H, Pehr K, Doré MA, Gilbert M, Zhou Y, Kupper TS, Sasseville D
Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients. Clin Cancer Res. 2014 Jul 15; 20(14):3799-808.
Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.
Huang Y, Litvinov IV, Wang Y, Su MW, Tu P, Jiang X, Kupper TS, Dutz JP, Sasseville D, Zhou Y
Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis. Oncotarget. 2014 Jun 30; 5(12):4418-25.
Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis.
Inhibiting Janus kinases to treat alopecia areata. Nat Med. 2014 Sep; 20(9):989-90.
Inhibiting Janus kinases to treat alopecia areata.
Personal reflections on 25 years of immunodermatology. Br J Dermatol. 2014 Oct; 171(4):684-6.
Personal reflections on 25 years of immunodermatology.
Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2014 Nov; 124(11):5085.
Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.
Litvinov IV, Cordeiro B, Fredholm S, Ødum N, Zargham H, Huang Y, Zhou Y, Pehr K, Kupper TS, Woetmann A, Sasseville D
Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines. Cell Cycle. 2014; 13(18):2975-82.
Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines.
Gaide O, Emerson RO, Jiang X, Gulati N, Nizza S, Desmarais C, Robins H, Krueger JG, Clark RA, Kupper TS
Common clonal origin of central and resident memory T cells following skin immunization. Nat Med. 2015 Jun; 21(6):647-53.
Common clonal origin of central and resident memory T cells following skin immunization.
Watanabe R, Gehad A, Yang C, Scott LL, Teague JE, Schlapbach C, Elco CP, Huang V, Matos TR, Kupper TS, Clark RA
Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med. 2015 Mar 18; 7(279):279ra39.
Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.
Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015 Mar 01; 194(5):2180-9.
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Tuzova M, Richmond J, Wolpowitz D, Curiel-Lewandrowski C, Chaney K, Kupper T, Cruikshank W
CCR4+T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin-16. Leuk Lymphoma. 2015 Feb; 56(2):440-9.
CCR4+T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin-16.
Nambudiri VE, Dwyer RC, Camargo CA, Kupper TS, Pallin DJ
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Outcome assessment in cellulitis clinical trials: is telephone follow up sufficient? Clin Microbiol Infect. 2015 Jul; 21(7):676.e5-7.
Outcome assessment in cellulitis clinical trials: is telephone follow up sufficient?
Litvinov IV, Netchiporouk E, Cordeiro B, Doré MA, Moreau L, Pehr K, Gilbert M, Zhou Y, Sasseville D, Kupper TS
The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL). Clin Cancer Res. 2015 Jun 15; 21(12):2820-9.
The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL).
The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med. 2015 Jul; 21(7):688-97.
The emerging role of resident memory T cells in protective immunity and inflammatory disease.
Jain S, Stroopinsky D, Yin L, Rosenblatt J, Alam M, Bhargava P, Clark RA, Kupper TS, Palmer K, Coll MD, Rajabi H, Pyzer A, Bar-Natan M, Luptakova K, Arnason J, Joyce R, Kufe D, Avigan D
Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma. Blood. 2015 Jul 16; 126(3):354-62.
Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma.
Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015 Sep 10; 162(6):1242-56.
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth.
Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, Sharpe AH, Waaga-Gasser AM, Sayegh MH, Abdi R, Scharffetter-Kochanek K, Murphy GF, Kupper TS, Frank NY, Frank MH
ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Rep. 2015 Sep 08; 12(10):1564-74.
ABCB5 Identifies Immunoregulatory Dermal Cells.
Goddard AL, Vleugels RA, LeBoeuf NR, O'Farrell DA, Cormack RA, Hansen JL, Kupper TS, Devlin PM
Palliative Therapy for Recalcitrant Cutaneous T-Cell Lymphoma of the Hands and Feet With Low-Dose, High Dose-Rate Brachytherapy. JAMA Dermatol. 2015 Dec 01; 151(12):1354-1357.
Palliative Therapy for Recalcitrant Cutaneous T-Cell Lymphoma of the Hands and Feet With Low-Dose, High Dose-Rate Brachytherapy.
Kirsch IR, Watanabe R, O'Malley JT, Williamson DW, Scott LL, Elco CP, Teague JE, Gehad A, Lowry EL, LeBoeuf NR, Krueger JG, Robins HS, Kupper TS, Clark RA
TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL. Sci Transl Med. 2015 Oct 07; 7(308):308ra158.
TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL.
Humanized Mice in Dermatology Research. J Invest Dermatol. 2015 Dec; 135(12):e39-e43.
Research Techniques Made Simple: Techniques to Assess Cell Proliferation. J Invest Dermatol. 2016 Jan; 136(1):e1-e7.
Research Techniques Made Simple: Techniques to Assess Cell Proliferation.
T Cells and Defensins: An Interface Between Innate and Acquired Immunity PASTEUR
Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586.
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
The Regulation and Expression of T-Lymphocyte Skin-Homing Receptors, CLA and CCR4-Implications for CTCL
Modeling the Response of CD8 + T Cells in the Skin
Collins N, Jiang X, Zaid A, Macleod BL, Li J, Park CO, Haque A, Bedoui S, Heath WR, Mueller SN, Kupper TS, Gebhardt T, Carbone FR
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation. Nat Commun. 2016 05 10; 7:11514.
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.
Timerman D, Devlin PM, Nambudiri VE, Wright NA, Vleugels RA, Clark RA, Kupper TS, Merola JF, Patel M
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis. Clin Exp Dermatol. 2016 Jul; 41(5):498-501.
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.
Obaitan I, Dwyer R, Lipworth AD, Kupper TS, Camargo CA, Hooper DC, Murphy GF, Pallin DJ
The American journal of emergency medicine
Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis. Am J Emerg Med. 2016 Aug; 34(8):1645-52.
Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis.
Transforming the diagnosis and care of patients with CTCL using TCR sequencing
Skin Homing T Cells -- Molecular Characterization of CLA
Cellular and Molecular Studies of Bone Marrow Transplant
Treatment of Autoimmune Disease by Costimulatory Signal*
IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
BIOLOGY OF SKIN COLLAGEN-BINDING BETA-1 INTEGRINS
MICROPLATE SCINTILLATION/LUMINESCENCE/FLOUR COUNTER
Vaccination to generate protective tissue resident T cells
Immunophysiology of Keratinocyte Cytokines
Clark SL, Tse JY, Fisher DC, LeBeouf NR, Murphy GF, Kupper TS, Clark RA, Lian CG
Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab). J Cutan Pathol. 2016 Nov; 43(11):989-993.
Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab).
Generation of Robust Resident Memory T cells in Barrier Tissues through Skin Vaccination
Pallin DJ, Bry L, Dwyer RC, Lipworth AD, Leung DY, Camargo CA, Kupper TS, Filbin MR, Murphy GF
Toward an Objective Diagnostic Test for Bacterial Cellulitis. PLoS One. 2016; 11(9):e0162947.
Toward an Objective Diagnostic Test for Bacterial Cellulitis.
Gunasekera NS, Divito JK, Kupper TS, Huang JT, Divito SJ
Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia. Pediatr Dermatol. 2017 Mar; 34(2):197-198.
Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia.
Jiang X, Park CO, Geddes Sweeney J, Yoo MJ, Gaide O, Kupper TS
Dermal ?d T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity. PLoS One. 2017; 12(1):e0169397.
Dermal ?d T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity.
Groves RW, Rauschmayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS
Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest. 1996 Jul 15; 98(2):336-44.
Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease.
The utility of transgenic mouse models in the study of cutaneous immunology and inflammation. J Dermatol. 1996 Nov; 23(11):741-5.
The utility of transgenic mouse models in the study of cutaneous immunology and inflammation.
Clark RA, Yamanaka K, Bai M, Dowgiert R, Kupper TS
Human skin cells support thymus-independent T cell development. J Clin Invest. 2005 Nov; 115(11):3239-49.
Human skin cells support thymus-independent T cell development.
Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, Grabbe S, von Andrian UH, Kupper TS
Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J Exp Med. 1999 Feb 15; 189(4):627-36.
Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance.
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183.
Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM
Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood. 1997 Aug 15; 90(4):1379-86.
Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors.
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256.
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med. 1999 Dec 09; 341(24):1817-28.
Inflammatory skin diseases, T cells, and immune surveillance.
The activated keratinocyte: a model for inducible cytokine production by non-bone marrow-derived cells in cutaneous inflammatory and immune responses. J Invest Dermatol. 1990 Jun; 94(6 Suppl):146S-150S.
The activated keratinocyte: a model for inducible cytokine production by non-bone marrow-derived cells in cutaneous inflammatory and immune responses.
Litvinov IV, Netchiporouk E, Cordeiro B, Zargham H, Pehr K, Gilbert M, Zhou Y, Moreau L, Woetmann A, Ødum N, Kupper TS, Sasseville D
Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. Oncoimmunology. 2014 Nov; 3(11):e970025.
Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma.
Song JS, Tawa M, Chau NG, Kupper TS, LeBoeuf NR
Aprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature. BMC Cancer. 2017 03 16; 17(1):200.
Aprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature.
Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18.
Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen.
Baker CC, Niven-Fairchild AT, Yamada A, Caragnano CL, Kupper TS
Macrophage antigen presentation and interleukin 1 production after cecal ligation and puncture in C3H/HeN and C3H/HeJ mice. Arch Surg. 1991 Feb; 126(2):253-7; discussion 257-8.
Macrophage antigen presentation and interleukin 1 production after cecal ligation and puncture in C3H/HeN and C3H/HeJ mice.
Müller-Röver S, Rossiter H, Lindner G, Peters EM, Kupper TS, Paus R
The journal of investigative dermatology. Symposium proceedings
Hair follicle apoptosis and Bcl-2. J Investig Dermatol Symp Proc. 1999 Dec; 4(3):272-7.
Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC
E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J Immunol. 2004 Feb 01; 172(3):1575-81.
E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.
Yamanaka K, Inaba T, Nomura E, Hurwitz D, Jones DA, Hakamada A, Isoda K, Kupper TS, Mizutani H
Basic fibroblast growth factor treatment for skin ulcerations in scleroderma. Cutis. 2005 Dec; 76(6):373-6.
Basic fibroblast growth factor treatment for skin ulcerations in scleroderma.
Turksen K, Kupper T, Degenstein L, Williams I, Fuchs E
Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):5068-72.
Interleukin 6: insights to its function in skin by overexpression in transgenic mice.
Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS
Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen. Eur J Immunol. 1998 12; 28(12):4221-7.
Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen.
Selectins, T-cell rolling and inflammation. Mol Med Today. 1997 May; 3(5):214-22.
Selectins, T-cell rolling and inflammation.
Yawalkar N, Ferenczi K, Jones DA, Yamanaka K, Suh KY, Sadat S, Kupper TS
Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma. Blood. 2003 Dec 01; 102(12):4059-66.
Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma.
Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity. J Invest Dermatol. 2000 Mar; 114(3):602-8.
Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity.
Kopp T, Kieffer JD, Rot A, Strommer S, Stingl G, Kupper TS
Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40. J Invest Dermatol. 2001 Sep; 117(3):618-26.
Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40.
Müller J, Friedrich M, Becher T, Braunstein J, Kupper T, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B
Journal of thrombosis and haemostasis : JTH
Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay. J Thromb Haemost. 2012 Mar; 10(3):390-8.
Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay.
Litvinov IV, Zhou Y, Kupper TS, Sasseville D
Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma. Leuk Lymphoma. 2013 Mar; 54(3):653-4.
Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma.
Hijnen D, Knol EF, Gent YY, Giovannone B, Beijn SJ, Kupper TS, Bruijnzeel-Koomen CA, Clark RA
CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-?, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013 Apr; 133(4):973-9.
CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-?, IL-13, IL-17, and IL-22.
In vivo exposure to IL-1 or ETAF causes a loss of antigen presenting cell function. Brit J. Rheumatol. 1985; 24:98.
In vivo exposure to IL-1 or ETAF causes a loss of antigen presenting cell function
Williams IR, Rawson EA, Manning L, Karaoli T, Rich BE, Kupper TS
IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. J Immunol. 1997 Sep 15; 159(6):3044-56.
IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells.
Murphy JE, Morales RE, Scott J, Kupper TS
IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis. J Immunol. 2003 Jun 01; 170(11):5697-703.
IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis.
Ferenczi K, Yawalkar N, Jones D, Kupper TS
Monitoring the decrease of circulating malignant T cells in cutaneous T-cell lymphoma during photopheresis and interferon therapy. Arch Dermatol. 2003 Jul; 139(7):909-13.
Monitoring the decrease of circulating malignant T cells in cutaneous T-cell lymphoma during photopheresis and interferon therapy.
Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant. 2004 Jul; 10(7):448-60.
Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model.
Yamanaka K, Yawalkar N, Jones DA, Hurwitz D, Ferenczi K, Eapen S, Kupper TS
Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma. Clin Cancer Res. 2005 Aug 15; 11(16):5748-55.
Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma.
Inaba T, Yamanaka K, Asahi K, Omoto Y, Isoda K, Hurwitz D, Kupper TS, Mizutani H
Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy. Eur J Dermatol. 2005 Sep-Oct; 15(5):411-3.
Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy.
Robert C, Klein C, Cheng G, Kogan A, Mulligan RC, von Andrian UH, Kupper TS
Gene therapy to target dendritic cells from blood to lymph nodes. Gene Ther. 2003 Aug; 10(17):1479-86.
Gene therapy to target dendritic cells from blood to lymph nodes.
Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology. Clin Dermatol. 2008 Sep-Oct; 26(5):554-61.
Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology.
Tian T, Jin MQ, Dubin K, King SL, Hoetzenecker W, Murphy GF, Chen CA, Kupper TS, Fuhlbrigge RC
IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection. J Immunol. 2017 06 01; 198(11):4341-4351.
IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection.
Black R, Kronheim S, Sleath P, Greenstreet T, Virca GD, March C, Kupper T
The proteolytic activation of interleukin-1 beta. Agents Actions Suppl. 1991; 35:85-9.
The proteolytic activation of interleukin-1 beta.
Rossi L, de Alencastro L, Kupper T, Tarradellas J
Urban stormwater contamination by polychlorinated biphenyls (PCBs) and its importance for urban water systems in Switzerland. Sci Total Environ. 2004 Apr 25; 322(1-3):179-89.
Urban stormwater contamination by polychlorinated biphenyls (PCBs) and its importance for urban water systems in Switzerland.
Berset JD, Kupper T, Etter R, Tarradellas J
Considerations about the enantioselective transformation of polycyclic musks in wastewater, treated wastewater and sewage sludge and analysis of their fate in a sequencing batch reactor plant. Chemosphere. 2004 Nov; 57(8):987-96.
Considerations about the enantioselective transformation of polycyclic musks in wastewater, treated wastewater and sewage sludge and analysis of their fate in a sequencing batch reactor plant.
Plagellat C, Kupper T, Furrer R, de Alencastro LF, Grandjean D, Tarradellas J
Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland. Chemosphere. 2006 Feb; 62(6):915-25.
Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.
Birchall N, Orlow SJ, Kupper T, Pawelek J
Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells. Biochem Biophys Res Commun. 1991 Mar 29; 175(3):839-45.
Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells.
Brändli RC, Kupper T, Bucheli TD, Zennegg M, Huber S, Ortelli D, Müller J, Schaffner C, Iozza S, Schmid P, Berger U, Edder P, Oehme M, Stadelmann FX, Tarradellas J
Journal of environmental monitoring : JEM
Organic pollutants in compost and digestate. Part 2. Polychlorinated dibenzo-p-dioxins, and -furans, dioxin-like polychlorinated biphenyls, brominated flame retardants, perfluorinated alkyl substances, pesticides, and other compounds. J Environ Monit. 2007 May; 9(5):465-72.
Organic pollutants in compost and digestate. Part 2. Polychlorinated dibenzo-p-dioxins, and -furans, dioxin-like polychlorinated biphenyls, brominated flame retardants, perfluorinated alkyl substances, pesticides, and other compounds.
Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8.
Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus.
Blanton RA, Kupper TS, McDougall JK, Dower S
Regulation of interleukin 1 and its receptor in human keratinocytes. Proc Natl Acad Sci U S A. 1989 Feb; 86(4):1273-7.
Regulation of interleukin 1 and its receptor in human keratinocytes.
Kupper T, Plagellat C, Brändli RC, de Alencastro LF, Grandjean D, Tarradellas J
Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment. Water Res. 2006 Aug; 40(14):2603-12.
Fate and removal of polycyclic musks, UV filters and biocides during wastewater treatment.
Kupper TS, Ballard DW, Chua AO, McGuire JS, Flood PM, Horowitz MC, Langdon R, Lightfoot L, Gubler U
Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1. J Exp Med. 1986 Dec 01; 164(6):2095-100.
Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.
Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S
Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002 Feb 01; 99(3):946-56.
Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1.
Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34.
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
Leukocyte Recruitment in Inflammatory Disease.
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Leukocyte recruitment in cutaneous inflammation
The Utility of transgenic mouse models in the study of cutaneous. J Dermatol. Review. 1996; 23(11):741-5.
The Utility of transgenic mouse models in the study of cutaneous
The Immune Consequence of Shock, Trauma and Sepsis, E. Faist, D. Green and J. Ninnemann, Eds
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The role of cytokines in the pathophysiology of T cell mediated skin disease. J Dermatol. 1987 Dec; 14(6):517-23.
The role of cytokines in the pathophysiology of T cell mediated skin disease.
Imiquimod: a topically applied link between innate and acquired immunity. Arch Dermatol. 2003 Oct; 139(10):1347-50.
Imiquimod: a topically applied link between innate and acquired immunity.
Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8072-6.
Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.
Brändli RC, Bucheli TD, Kupper T, Furrer R, Stadelmann FX, Tarradellas J
Persistent organic pollutants in source-separated compost and its feedstock materials--a review of field studies. J Environ Qual. 2005 May-Jun; 34(3):735-60.
Persistent organic pollutants in source-separated compost and its feedstock materials--a review of field studies.
Hydrocortisone reduces both constitutive and UV-elicited release of epidermal thymocyte activating factor (ETAF) by cultured keratinocytes. J Invest Dermatol. 1986 Nov; 87(5):570-3.
Hydrocortisone reduces both constitutive and UV-elicited release of epidermal thymocyte activating factor (ETAF) by cultured keratinocytes.
Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 01; 180(1):95-109.
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
Groves RW, Sherman L, Mizutani H, Dower SK, Kupper TS
Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis. Am J Pathol. 1994 Nov; 145(5):1048-56.
Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis.
Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS
Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991 Oct 18; 67(2):403-10.
Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells.
Bianchi T, Pincus LB, Wurbel MA, Rich BE, Kupper TS, Fuhlbrigge RC, Boes M
Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol. 2009 Apr 15; 182(8):4665-74.
Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.
Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS
The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006 Oct 01; 177(7):4488-94.
The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
Dower SK, Qwarnstrom EE, Page RC, Blanton RA, Kupper TS, Raines E, Ross R, Sims JE
Biology of the interleukin-1 receptor. J Invest Dermatol. 1990 Jun; 94(6 Suppl):68S-73S.
Kupper T, Horowitz M, Lee F, Robb R, Flood PM
Autocrine growth of T cells independent of interleukin 2: identification of interleukin 4 (IL 4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell. J Immunol. 1987 Jun 15; 138(12):4280-7.
Autocrine growth of T cells independent of interleukin 2: identification of interleukin 4 (IL 4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell.
Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15.
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.
Carcamo AS, Fuhlbrigge RC, Hong R, Gullans SR, Kupper TS
Comparative analysis of the global transcriptional profile of human skin-homing memory T lymphocytes vs. non-skin homing memory and naive T lymphocytes J Invest Dermatol. 2000 Aug; 115(2):332.
Comparative analysis of the global transcriptional profile of human skin-homing memory T lymphocytes vs. non-skin homing memory and naive T lymphocytes
Brändli RC, Bucheli TD, Kupper T, Furrer R, Stahel WA, Stadelmann FX, Tarradellas J
Organic pollutants in compost and digestate. Part 1. Polychlorinated biphenyls, polycyclic aromatic hydrocarbons and molecular markers. J Environ Monit. 2007 May; 9(5):456-64.
Organic pollutants in compost and digestate. Part 1. Polychlorinated biphenyls, polycyclic aromatic hydrocarbons and molecular markers.
McGuire J, Langdon R, Birchall N, Kupper T
Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes. Ann N Y Acad Sci. 1988; 548:283-90.
Interleukin-1 alpha mRNA induced by cycloheximide PMA, and retinoic acid is reduced by dexamethasone in PAM-212 keratinocytes.
Kupper TS, Min K, Sehgal P, Mizutani H, Birchall N, Ray A, May L
Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity. Ann N Y Acad Sci. 1989; 557:454-64; discussion 464-5.
Production of IL-6 by keratinocytes. Implications for epidermal inflammation and immunity.
Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26; 6(1):e16245.
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity.
Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med. 2010 Feb; 16(2):224-7.
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.
The American Journal of dermatopathology
Production of cytokines by epithelial tissues. A new model for cutaneous inflammation. Am J Dermatopathol. 1989 Feb; 11(1):69-73.
Production of cytokines by epithelial tissues. A new model for cutaneous inflammation.
Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW
Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.
Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.
Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Aug; 18(8):1248-53.
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Jain S, Washington A, Leaf RK, Bhargava P, Clark RA, Kupper TS, Stroopinsky D, Pyzer A, Cole L, Nahas M, Apel A, Rosenblatt J, Arnason J, Kufe D, Avigan D
Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma. Mol Cancer Ther. 2017 10; 16(10):2304-2314.
Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma.
Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages. J Immunol. 1988 Feb 01; 140(3):832-6.
Keratinocyte-derived granulocyte/macrophage colony-stimulating factor induces DNA synthesis by peritoneal macrophages.
Pawelek J, Orlow S, Kupper TS, Birchall N.
Recombinant human IL-1 alpha induces melanocyte-stimulating homone (MSH) receptor expression and enhances MSH-mediated melnaonogenesis. Biochem. Biophys. Res. Comm. 1991; 175:839.
Recombinant human IL-1 alpha induces melanocyte-stimulating homone (MSH) receptor expression and enhances MSH-mediated melnaonogenesis
Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest. 1991 Mar; 87(3):1066-71.
Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.
Chaudry IH, Schleck S, Clemens MG, Kupper TE, Baue AE
Altered hepatocellular active transport. An early change in peritonitis. Arch Surg. 1982 Feb; 117(2):151-7.
Altered hepatocellular active transport. An early change in peritonitis.
Lee RT, Briggs WH, Cheng GC, Rossiter HB, Libby P, Kupper T
Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist. J Immunol. 1997 Nov 15; 159(10):5084-8.
Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist.
Mizutani H, Ohmoto Y, Kupper TS, Shimizu M
Endogenous neutralizing anti-IL-1 alpha autoantibodies in inflammatory skin diseases: possible natural inhibitor for over expressed epidermal IL-1. J Dermatol Sci. 1998 May; 20(1):63-71.
Endogenous neutralizing anti-IL-1 alpha autoantibodies in inflammatory skin diseases: possible natural inhibitor for over expressed epidermal IL-1.
A new rexinoid for cutaneous t-cell lymphoma. Arch Dermatol. 2001 May; 137(5):649-52.
A new rexinoid for cutaneous t-cell lymphoma.
Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS
International archives of allergy and immunology
Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity. Int Arch Allergy Immunol. 2001 Sep; 126(1):78-90.
Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity.
Adams AE, Zwicker J, Curiel C, Kadin ME, Falchuk KR, Drews R, Kupper TS
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Aggressive cutaneous T-cell lymphomas after TNFalpha blockade.
Fuhlbrigge RC, King SL, Sackstein R, Kupper TS
CD43 is a ligand for E-selectin on CLA+ human T cells. Blood. 2006 Feb 15; 107(4):1421-6.
CD43 is a ligand for E-selectin on CLA+ human T cells.
Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS
The vast majority of CLA+ T cells are resident in normal skin. J Immunol. 2006 Apr 01; 176(7):4431-9.
The vast majority of CLA+ T cells are resident in normal skin.
Litvinov IV, Jones DA, Sasseville D, Kupper TS
Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res. 2010 Apr 01; 16(7):2106-14.
Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma.
Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85.
VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth.
Matos TR, O'Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA
Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing aß T cell clones. J Clin Invest. 2017 Nov 01; 127(11):4031-4041.
Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing aß T cell clones.
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Restoration of the immune response following burn injury with low doese cyclophosphamide. Surg. Forum. 1981; 32:60.
Restoration of the immune response following burn injury with low doese cyclophosphamide
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Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin.
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Functional cutaneous lymphocyte antigen can be induced in essentially all peripheral blood T lymphocytes.
Dayan S, Stashenko P, Niederman R, Kupper TS
Oral epithelial overexpression of IL-1alpha causes periodontal disease. J Dent Res. 2004 Oct; 83(10):786-90.
Oral epithelial overexpression of IL-1alpha causes periodontal disease.
Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R
Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51.
Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots.
Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS
Increased CCR4 expression in cutaneous T cell lymphoma. J Invest Dermatol. 2002 Dec; 119(6):1405-10.
Increased CCR4 expression in cutaneous T cell lymphoma.
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Interleukin-1 and T cell function following injury. J Burn Care Rehabil. 1987 Nov-Dec; 8(6):503-8.
Interleukin-1 and T cell function following injury.
Jacobson BK, Cuono CB, Kupper TS, Baker CC
Immunologic alterations following excisional wounding and immediate repair with syngeneic or allogeneic skin grafts. J Burn Care Rehabil. 1988 Jul-Aug; 9(4):354-8.
Immunologic alterations following excisional wounding and immediate repair with syngeneic or allogeneic skin grafts.
The role of endotoxin in intra-abdominal sepsis. Surg Forum. 1985; 36:68.
The role of endotoxin in intra-abdominal sepsis
Nambudiri VE, Watson AJ, Buzney EA, Kupper TS, Rubenstein MH, Yang FC
Medical Scribes in an Academic Dermatology Practice. JAMA Dermatol. 2018 01 01; 154(1):101-103.
Medical Scribes in an Academic Dermatology Practice.
Liu L, Fuhlbrigge RC, Karibian K, Tian T, Kupper TS
Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity. 2006 Sep; 25(3):511-20.
Dynamic programming of CD8+ T cell trafficking after live viral immunization.
Brändli RC, Bucheli TD, Kupper T, Mayer J, Stadelmann FX, Tarradellas J
Environmental pollution (Barking, Essex : 1987)
Fate of PCBs, PAHs and their source characteristic ratios during composting and digestion of source-separated organic waste in full-scale plants. Environ Pollut. 2007 Jul; 148(2):520-8.
Fate of PCBs, PAHs and their source characteristic ratios during composting and digestion of source-separated organic waste in full-scale plants.
Shin J, Monti S, Aires DJ, Duvic M, Golub T, Jones DA, Kupper TS
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome. Blood. 2007 Oct 15; 110(8):3015-27.
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome.
Chaudry IH, Kupper TS, Schleck S, Clemens MG, Baue AE
Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administration. Circ Shock. 1982; 9(3):297-305.
Impairment of reticuloendothelial function following thermal injury and its restoration with ATP-MgCl2 administration.
Ayehunie S, Groves RW, Bruzzese AM, Ruprecht RM, Kupper TS, Langhoff E
Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact. AIDS Res Hum Retroviruses. 1995 Aug; 11(8):877-84.
Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact.
The interleukin-1 axis and cutaneous inflammation. J Invest Dermatol. 1995 Jul; 105(1 Suppl):62S-66S.
The interleukin-1 axis and cutaneous inflammation.
Yamanaka K, Fuhlbrigge RC, Mizutani H, Kupper TS
Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma. Arch Dermatol Res. 2010 Aug; 302(6):453-9.
Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma.
Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol. 2004 Mar; 4(3):211-22.
Immune surveillance in the skin: mechanisms and clinical consequences.
Williams IR, Ort RJ, Daley D, Manning L, Karaoli T, Barnhill RL, Kupper TS
Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas. J Immunol. 1996 May 01; 156(9):3382-8.
Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas.
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin Cancer Res. 2006 Jan 15; 12(2):376-82.
Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
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Cutaneous Oncology: Basal and Squamous Cell Carcinomas
Breslin RJ, Barbul A, Kupper TS, Knud-Hansen JP, Wasserkrug HL, Efron G
Generation of an anti-interleukin 2 factor in healing wounds. Arch Surg. 1988 Mar; 123(3):305-8.
Generation of an anti-interleukin 2 factor in healing wounds.
Coleman DL, Kupper TS, Flood PM, Fultz CC, Horowitz MC
Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1. J Immunol. 1987 May 15; 138(10):3314-8.
Characterization of a keratinocyte-derived T cell growth factor distinct from interleukin 2 and B cell stimulatory factor 1.
Alon R, Rossiter H, Springer T, Kupper TS.
Rolling of T lymphocytes on P and E Selectins under physiological flow conditions is mediated by distinct cell surface ligands. J. Cell. Biol. 1994; 127:1485-1495.
Rolling of T lymphocytes on P and E Selectins under physiological flow conditions is mediated by distinct cell surface ligands
Kupper T, de Alencastro LF, Gatsigazi R, Furrer R, Grandjean D, Tarradellas J
Concentrations and specific loads of brominated flame retardants in sewage sludge. Chemosphere. 2008 Apr; 71(6):1173-80.
Concentrations and specific loads of brominated flame retardants in sewage sludge.
Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS
Staged development of long-lived T-cell receptor aß TH17 resident memory T-cell population to Candida albicans after skin infection. J Allergy Clin Immunol. 2018 08; 142(2):647-662.
Staged development of long-lived T-cell receptor aß TH17 resident memory T-cell population to Candida albicans after skin infection.
Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma. Blood. 2011 Feb 10; 117(6):1966-76.
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.
Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH
Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.
Identification of cells initiating human melanomas.
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The role of cytokines and adhesion molecules in inflammatory skin disease
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
A potential pathophysiologic role for alpha 2 beta 1 integrin in human eye diseases involving vitreoretinal traction. FASEB J. 1993 Nov; 7(14):1401-6.
A potential pathophysiologic role for alpha 2 beta 1 integrin in human eye diseases involving vitreoretinal traction.
Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6367-71.
Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.
Schneider EG, Armant DR, Kupper TS, Polan ML
Absence of a direct effect of recombinant interleukins and cultured peritoneal macrophages on early embryonic development in the mouse. Biol Reprod. 1989 Apr; 40(4):825-33.
Absence of a direct effect of recombinant interleukins and cultured peritoneal macrophages on early embryonic development in the mouse.
Old and new: recent innovations in vaccine biology and skin T cells. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):829-34.
Old and new: recent innovations in vaccine biology and skin T cells.
Weishaupt C, Munoz KN, Buzney E, Kupper TS, Fuhlbrigge RC
T-cell distribution and adhesion receptor expression in metastatic melanoma. Clin Cancer Res. 2007 May 01; 13(9):2549-56.
T-cell distribution and adhesion receptor expression in metastatic melanoma.
Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest. 1990 Dec; 86(6):1783-9.
Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.
Rossiter H, van Reijsen F, Mudde GC, Kalthoff F, Bruijnzeel-Koomen CA, Picker LJ, Kupper TS
Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding. Eur J Immunol. 1994 Jan; 24(1):205-10.
Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding.
Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9710-4.
Epidermal expression of intercellular adhesion molecule 1 is not a primary inducer of cutaneous inflammation in transgenic mice.
Kupper TS, Lee F, Birchall N, Clark S, Dower S
Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis. J Clin Invest. 1988 Nov; 82(5):1787-92.
Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis.
Yamanaka KI, Kakeda M, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Kupper TS, Mizutani H
1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration. Br J Dermatol. 2010 Jun; 162(6):1206-15.
1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration.
Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12; 119(15):3534-8.
Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma.
Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA
Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455.
Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma.
Mizutani H, Ohyanagi S, Umeda Y, Shimizu M, Kupper TS
Loss of cutaneous delayed hypersensitivity reactions in nevus anemicus. Evidence for close concordance of cutaneous delayed hypersensitivity and endothelial E-selectin expression. Arch Dermatol. 1997 May; 133(5):617-20.
Loss of cutaneous delayed hypersensitivity reactions in nevus anemicus. Evidence for close concordance of cutaneous delayed hypersensitivity and endothelial E-selectin expression.
HIV-infected Langerhans cells constitute a significant proportion of the epidermal Langerhans cell population throughout the course of HIV disease. J Invest Dermatol. 1996 Dec; 107(6):822-6.
HIV-infected Langerhans cells constitute a significant proportion of the epidermal Langerhans cell population throughout the course of HIV disease.
T cells, immunosurveillance, and cutaneous immunity. J Dermatol Sci. 2000 Dec; 24 Suppl 1:S41-5.
T cells, immunosurveillance, and cutaneous immunity.
Immunologic targets in psoriasis. N Engl J Med. 2003 Nov 20; 349(21):1987-90.
Mizutani H, Schechter N, Lazarus G, Black RA, Kupper TS
Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med. 1991 Oct 01; 174(4):821-5.
Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.
Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS
Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature. 1997 Oct 30; 389(6654):978-81.
Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.
Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1. Surgery. 1985 Aug; 98(2):199-206.
Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1.
Old meets new: the interaction between innate and adaptive immunity. J Invest Dermatol. 2005 Oct; 125(4):629-37.
Old meets new: the interaction between innate and adaptive immunity.
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 2007 Jan 01; 109(1):194-202.
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z
PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10; 49(1):145-57.
PGC-1 coactivators regulate MITF and the tanning response.
Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA
Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Mol Cancer Ther. 2012 Nov; 11(11):2451-61.
Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells.
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"Adhesion molecules, matrix, and cytokines: intregration during leukocyte migration"
Interleukin 1 and other keratinocyte cytokines: molecular and functional characterization. Adv. Derm. 1988; 3:293.
Interleukin 1 and other keratinocyte cytokines: molecular and functional characterization
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"The role of cytokines and adhesion molecules in inflammatory skin diseasae". Cytokines: Clinical Applications, J. Oppenheim, A. Gearing, Ed. 1993; New York.
"The role of cytokines and adhesion molecules in inflammatory skin diseasae"
Pharmacology and the Skin, Basel, Karger
The role of epidermal cytokines in cutaneous immune and inflammatory reactions. Pharmacology and the Skin, Basel, Karger. 1991; 4:37-31.
The role of epidermal cytokines in cutaneous immune and inflammatory reactions
Turksen K, Kupper TS, Degenstein L, Williams I, Sarkar S, Fuchs E.
IL-6 Insights to its function in skin by expression in transgenic mice. Proc. Natl, Acad. Sci. 1992; 89:5068-72.
IL-6 Insights to its function in skin by expression in transgenic mice
Kupper TS, Green DR, Chaudry IH, Fox A, Baue AE
A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injury. Surgery. 1984 Jun; 95(6):699-706.
A cyclophosphamide-sensitive suppressor T cell circuit induced by thermal injury.
Rossiter H, Beissert S, Mayer C, Schön MP, Wienrich BG, Tschachler E, Kupper TS
Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis. Cancer Res. 2001 May 01; 61(9):3619-26.
Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis.
Kieffer JD, Fuhlbrigge RC, Armerding D, Robert C, Ferenczi K, Camphausen RT, Kupper TS
Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen. Biochem Biophys Res Commun. 2001 Jul 20; 285(3):577-87.
Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen.