YX7XuYuXu Yu, M.D.42.37730000000000-71.0525000000000032729Yu, Xu857/268-7004Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson12163589Yu XG, Addo MM, Rosenberg ES, Rodriguez WR, Lee PK, Fitzpatrick CA, Johnston MN, Strick D, Goulder PJ, Walker BD, Altfeld MJournal of virologyConsistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection. J Virol. 2002 Sep; 76(17):8690-701.J Virol2002-09-01T00:00:002002Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.14685052Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, Rockstroh JK, Goulder PJ, Walker BDAIDS (London, England)Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS. 2003 Dec 05; 17(18):2581-91.AIDS2003-12-05T00:00:002003Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.15194783Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, Rosenberg ES, Mallal SA, Goulder PJ, Brander C, Walker BDJournal of virologySelection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J Virol. 2004 Jul; 78(13):7069-78.J Virol2004-07-01T00:00:002004Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.15790309Yu XG, Lichterfeld M, Addo MM, Altfeld MCurrent medicinal chemistryRegulatory and accessory HIV-1 proteins: potential targets for HIV-1 vaccines? Curr Med Chem. 2005; 12(6):741-7.Curr Med Chem2005-01-01T00:00:002005Regulatory and accessory HIV-1 proteins: potential targets for HIV-1 vaccines?18728248Lichterfeld M, Mou D, Cung TD, Williams KL, Waring MT, Huang J, Pereyra F, Trocha A, Freeman GJ, Rosenberg ES, Walker BD, Yu XGBloodTelomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood. 2008 Nov 01; 112(9):3679-87.Blood2008-08-26T00:00:002008Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors.20588158Williams K, Seiss K, Beamon J, Pereyra F, Rosenberg ES, Walker BD, Yu XG, Lichterfeld MAIDS (London, England)Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells. AIDS. 2010 Jul 31; 24(12):1964-6.AIDS2010-07-31T00:00:002010Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells.20702625Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, Toth I, Pereyra F, Lichterfeld M, Yu XGJournal of virologySoluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2. J Virol. 2010 Oct; 84(20):10784-91.J Virol2010-08-11T00:00:002010Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2.12525643Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, Johnston MN, Corcoran C, Wurcel AG, Fitzpatrick CA, Feeney ME, Rodriguez WR, Basgoz N, Draenert R, Stone DR, Brander C, Goulder PJ, Rosenberg ES, Altfeld M, Walker BDJournal of virologyComprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol. 2003 Feb; 77(3):2081-92.J Virol2003-02-01T00:00:002003Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.21403397Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld MThe Journal of clinical investigationCD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J Clin Invest. 2011 Apr; 121(4):1549-60.J Clin Invest2011-03-14T00:00:002011CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21.15186531Yu XG, Addo MM, Perkins BA, Wej F, Rathod A, Geer SC, Parta M, Cohen D, Stone DR, Russell CJ, Tanzi G, Mei S, Wurcel AG, Frahm N, Lichterfeld M, Heath L, Mullins JI, Marincola F, Goulder PJ, Brander C, Allen T, Cao Y, Walker BD, Altfeld MAIDS research and human retrovirusesDifferences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians. AIDS Res Hum Retroviruses. 2004 May; 20(5):557-64.AIDS Res Hum Retroviruses2004-05-01T00:00:002004Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.20631139Huang J, Burke PS, Cung TD, Pereyra F, Toth I, Walker BD, Borges L, Lichterfeld M, Yu XGJournal of virologyLeukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol. 2010 Sep; 84(18):9463-71.J Virol2010-07-14T00:00:002010Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.22028331Lichterfeld M, Yu XGJournal of leukocyte biologyThe emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection. J Leukoc Biol. 2012 Jan; 91(1):27-33.J Leukoc Biol2011-10-25T00:00:002011The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection.17076553Altfeld M, Kalife ET, Qi Y, Streeck H, Lichterfeld M, Johnston MN, Burgett N, Swartz ME, Yang A, Alter G, Yu XG, Meier A, Rockstroh JK, Allen TM, Jessen H, Rosenberg ES, Carrington M, Walker BDPLoS medicineHLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1. PLoS Med. 2006 Oct; 3(10):e403.PLoS Med2006-10-01T00:00:002006HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.22301416Yang Y, Al-Mozaini M, Buzon MJ, Beamon J, Ferrando-Martinez S, Ruiz-Mateos E, Rosenberg ES, Pereyra F, Yu XG, Lichterfeld MAIDS (London, England)CD4 T-cell regeneration in HIV-1 elite controllers. AIDS. 2012 Mar 27; 26(6):701-6.AIDS2012-03-27T00:00:002012CD4 T-cell regeneration in HIV-1 elite controllers.21963936Lichterfeld M, Gandhi RT, Simmons RP, Flynn T, Sbrolla A, Yu XG, Basgoz N, Mui S, Williams K, Streeck H, Burgett-Yandow N, Roy G, Janssens M, Pedneault L, Vandepapelière P, Koutsoukos M, Demoitié MA, Bourguignon P, McNally L, Voss G, Altfeld MJournal of acquired immune deficiency syndromes (1999)Induction of strong HIV-1-specific CD4+ T-cell responses using an HIV-1 gp120/NefTat vaccine adjuvanted with AS02A in antiretroviral-treated HIV-1-infected individuals. J Acquir Immune Defic Syndr. 2012 Jan 01; 59(1):1-9.J Acquir Immune Defic Syndr2012-01-01T00:00:002012Induction of strong HIV-1-specific CD4+ T-cell responses using an HIV-1 gp120/NefTat vaccine adjuvanted with AS02A in antiretroviral-treated HIV-1-infected individuals.17804503Yu XG, Lichterfeld M, Williams KL, Martinez-Picado J, Walker BDJournal of virologyRandom T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain. J Virol. 2007 Nov; 81(22):12666-9.J Virol2007-09-05T00:00:002007Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.Microbiology11834942Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander C, Goulder PJ, Rosenberg ES, Walker BD, Altfeld MAIDS (London, England)Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS. 2002 Feb 15; 16(3):321-8.AIDS2002-02-15T00:00:002002Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.15199314Lichterfeld M, Yu XG, Cohen D, Addo MM, Malenfant J, Perkins B, Pae E, Johnston MN, Strick D, Allen TM, Rosenberg ES, Korber B, Walker BD, Altfeld MAIDS (London, England)HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS. 2004 Jul 02; 18(10):1383-92.AIDS2004-07-02T00:00:002004HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.17121793Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BDJournal of virologyMutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J Virol. 2007 Feb; 81(4):1619-31.J Virol2006-11-22T00:00:002006Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.2021-05-31YU, XU2018-08-15Molecular profile of proviral reservoirs in HIV-infected drug usersR61DA047034Principal Investigator16135897Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, Chen J, Cheng M, Kang W, Alter G, Brander C, Walker BD, Altfeld MAIDS (London, England)High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS. 2005 Sep 23; 19(14):1449-56.AIDS2005-09-23T00:00:002005High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.Authorship 1121817Authorship 10630419D015497Living Beings83469310.277707HIV-1D013602Anatomy58918220.571508T-Lymphocytes, CytotoxicD020276Living Beings681260.916988HIV Long-Term SurvivorsD015658Disorders1931167640.15209HIV InfectionsD018414Anatomy137544240.370362CD8-Positive T-LymphocytesMedicinePathologyInfectious DiseaseVaccine ResearchBeth Israel Deaconess Medical CenterBrigham and Women's HospitalDana-Farber Cancer InstituteMassachusetts General HospitalKHM2KennethMayerKenneth Hugh Mayer, M.D.42.34652700000000-71.0878720000000068578Mayer, KennethProfessor of MedicineKristaDongKrista Louise Dong, M.D.42.37730000000000-71.0525000000000034982Dong, KristaMember of the Faculty of MedicineZMN1ZazaNdhlovuZaza Mtine Ndhlovu, Ph.D.42.37730000000000-71.0525000000000038891Ndhlovu, ZazaAssistant Professor of Medicine, Part-timeBDW1BruceWalkerBruce David Walker, M.D.42.37730000000000-71.0525000000000079342Walker, BrucePhillip T. and Susan M. Ragon Professor of MedicineDHB3DanBarouchDan Hung Barouch, M.D.42.34022770000000-71.1058540000000028268Barouch, DanWilliam Bosworth Castle Professor of MedicineML79MathiasLichterfeldMathias Lichterfeld, M.D., Ph.D.42.37730000000000-71.0525000000000043487Lichterfeld, MathiasProfessor of MedicineESR2EricRosenbergEric Scott Rosenberg, M.D.42.36241700000000-71.0689370000000065644Rosenberg, EricProfessor of PathologyGA25GalitAlterGalit Alter, Ph.D.42.37730000000000-71.0525000000000083846Alter, GalitProfessor of Medicine (on leave)JGS10JosephSodroskiJoseph Gerard Sodroski, M.D.42.33789600000000-71.1072493000000042351Sodroski, JosephProfessor of Microbiology1152selected publications2.257920.00170393172research areas3.930160.015915317coauthor of102.4818.6610660similar toTA15ToddAllenTodd Allen, Ph.D.42.37730000000000-71.0525000000000081018Allen, ToddProfessor of MedicineDRK3DanielKuritzkesDaniel Robert Kuritzkes, M.D.42.36070000000000-71.1009000000000062664Kuritzkes, DanielHarriet Ryan Albee Professor of MedicineAuthorship 1150441true1Professor of PathologyProfessor of Pathologytrue1Professor of MedicineProfessor of Medicinetrue1Professor of MicrobiologyProfessor of Microbiologytrue1Assistant Professor of Medicine, Part-timeAssistant Professor of Medicine, Part-timetrue1Harriet Ryan Albee Professor of MedicineHarriet Ryan Albee Professor of MedicineAuthorship 1719256Authorship 186800192025-08-31YU, XU2020-09-23Elite controllers as a model for a cure of HIV-1 infectionR01AI155171Principal InvestigatorAuthorship 14628562025-08-31YU, XU2020-09-23Elite controllers as a model for a cure of HIV-1 infectionR37AI155171Principal Investigatortrue1Professor of MedicineProfessor of MedicineAuthorship 2863802Authorship 3490601Authorship 2177825Ragon Institute of MGH, MIT and HarvardAuthorship 3652502true1William Bosworth Castle Professor of MedicineWilliam Bosworth Castle Professor of Medicinetrue1Phillip T. and Susan M. Ragon Professor of MedicinePhillip T. and Susan M. Ragon Professor of Medicinetrue1Member of the Faculty of MedicineMember of the Faculty of Medicine2028-04-30YU, XU2023-08-01Characterizing HIV-1 reservoirs in the central nervous systemR01MH134823Principal Investigatortrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of Medicine (on leave)Professor of Medicine (on leave)Authorship 582640Authorship 3863311Authorship 3419272Authorship 3439215Authorship 1982966Authorship 2089703Authorship 2325937Authorship 29785612Authorship 35519311Authorship 3801627Authorship 874914Authorship 9475510Authorship 4691769Authorship 44069611Authorship 49684612Authorship 2694505Authorship 606362Authorship 33001710Authorship 4320291Authorship 590340Authorship 57162317Authorship 2675715Authorship 3777531Authorship 4507998Authorship 23065111Authorship 4913881Authorship 1533418Authorship 2519782Authorship 4824393Authorship 5585872Authorship 4926693Authorship 5271603Authorship 4395827Authorship 5591402Authorship 55102912Assistant Professor0Full Professor5Other FacultyAuthorship 5652129Authorship 607372Authorship 87239162016-08-31YU, XU2014-09-19Targeting HIV-1 persistence with Interferon-aR21AI1162282016-08-31YU, XU2014-09-05A systems biology approach to fingerprint HIV immune defense in Elite ControllersR56HL1265542020-07-31YU, XU2008-04-01Immunoregulatory Function of Myelomonocytic Receptors in HIV-1 InfectionR01AI0787992008-09-30YU, XU2006-01-01Functional Proteomics of HIV-1-Specific CD8+ T cellsR21AI0684992016-12-31YU, XU2014-01-01T memory stem cell aging in HIV-1 infectionR21HL1218902015-08-31YU, XU2012-09-01A systems biology approach to fingerprint HIV immune defense in Elite ControllersR56AI0984842015-08-31YU, XU2010-09-15A Microengraving Technology for the Study of Latently HIV-infected Primary CellsR01AI089339Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator2021-06-30YU, XU2016-09-01A systems biology approach to fingerprint HIV immune defense in Elite ControllersR01HL1345392020-08-31YU, XU2016-09-01Targeting HIV-1 persistence with Interferon-aR33AI116228Principal InvestigatorPrincipal InvestigatorAuthorship 3256502Authorship 4556901Authorship 4623709Authorship 41708114400 Technology SquareRagon Institute of MGH, MIT and Harvard10th Fl, Room 1023400 Technology SquareCambridge02139MA15060434Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJAIDS (London, England)Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. AIDS. 2004 Apr 09; 18(6):871-6.AIDS2004-04-09T00:00:002004Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.11901192Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer-Olson D, Stellbrink HJ, Walker BDThe Journal of clinical investigationExpansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection. J Clin Invest. 2002 Mar; 109(6):837-43.J Clin Invest2002-03-01T00:00:002002Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.15381726Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld MThe Journal of experimental medicineLoss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med. 2004 Sep 20; 200(6):701-12.J Exp Med2004-09-20T00:00:002004Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.16002429Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld MBloodSequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 2005 Nov 15; 106(10):3366-9.Blood2005-07-07T00:00:002005Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection.11953475Addo MM, Altfeld M, Rathod A, Yu M, Yu XG, Goulder PJ, Rosenberg ES, Walker BDAIDS (London, England)HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection. AIDS. 2002 May 03; 16(7):1071-3.AIDS2002-05-03T00:00:002002HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.15944251Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, Hazra R, Klenerman P, Altfeld M, Walker BD, Goulder PJJournal of immunology (Baltimore, Md. : 1950)HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J Immunol. 2005 Jun 15; 174(12):7524-30.J Immunol2005-06-15T00:00:002005HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.15745859Lichterfeld M, Yu XG, Le Gall S, Altfeld MTrends in immunologyImmunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics. Trends Immunol. 2005 Mar; 26(3):166-71.Trends Immunol2005-03-01T00:00:002005Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.15470077Alter G, Malenfant JM, Delabre RM, Burgett NC, Yu XG, Lichterfeld M, Zaunders J, Altfeld MJournal of immunology (Baltimore, Md. : 1950)Increased natural killer cell activity in viremic HIV-1 infection. J Immunol. 2004 Oct 15; 173(8):5305-11.J Immunol2004-10-15T00:00:002004Increased natural killer cell activity in viremic HIV-1 infection.12396610Addo MM, Yu XG, Rosenberg ES, Walker BD, Altfeld MDNA and cell biologyCytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection. DNA Cell Biol. 2002 Sep; 21(9):671-8.DNA Cell Biol2002-09-01T00:00:002002Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection.20008523Huang J, Goedert JJ, Sundberg EJ, Cung TD, Burke PS, Martin MP, Preiss L, Lifson J, Lichterfeld M, Carrington M, Yu XGThe Journal of experimental medicineHLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses. J Exp Med. 2009 Dec 21; 206(13):2959-66.J Exp Med2009-12-14T00:00:002009HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses.12805431Altfeld M, Addo MM, Shankarappa R, Lee PK, Allen TM, Yu XG, Rathod A, Harlow J, O'Sullivan K, Johnston MN, Goulder PJ, Mullins JI, Rosenberg ES, Brander C, Korber B, Walker BDJournal of virologyEnhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences. J Virol. 2003 Jul; 77(13):7330-40.J Virol2003-07-01T00:00:002003Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.15795285Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BDJournal of virologyThe majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5.J Virol2005-04-01T00:00:002005The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.21969335Huang J, Yang Y, Al-Mozaini M, Burke PS, Beamon J, Carrington MF, Seiss K, Rychert J, Rosenberg ES, Lichterfeld M, Yu XGThe Journal of infectious diseasesDendritic cell dysfunction during primary HIV-1 infection. J Infect Dis. 2011 Nov 15; 204(10):1557-62.J Infect Dis2011-10-03T00:00:002011Dendritic cell dysfunction during primary HIV-1 infection.22683743Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BDNature immunologyTCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol. 2012 Jun 10; 13(7):691-700.Nat Immunol2012-06-10T00:00:002012TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.16188997Allen TM, Yu XG, Kalife ET, Reyor LL, Lichterfeld M, John M, Cheng M, Allgaier RL, Mui S, Frahm N, Alter G, Brown NV, Johnston MN, Rosenberg ES, Mallal SA, Brander C, Walker BD, Altfeld MJournal of virologyDe novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J Virol. 2005 Oct; 79(20):12952-60.J Virol2005-10-01T00:00:002005De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.12459786Altfeld M, Allen TM, Yu XG, Johnston MN, Agrawal D, Korber BT, Montefiori DC, O'Connor DH, Davis BT, Lee PK, Maier EL, Harlow J, Goulder PJ, Brander C, Rosenberg ES, Walker BDNatureHIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus. Nature. 2002 Nov 28; 420(6914):434-9.Nature2002-11-28T00:00:002002HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.18385228Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TMJournal of virologyStructural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol. 2008 Jun; 82(11):5594-605.J Virol2008-04-02T00:00:002008Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.Zhai S, Kang WZ, Yu X, Wang SY, Walker BD, Altfeld M, Sun YT. [Specific immune responses to human immunodeficiency virus type 1 Gag, Tat, Rev and Nef proteins.]. 2005; 2(21):175-9.2005-03-21T00:00:002005[Specific immune responses to human immunodeficiency virus type 1 Gag, Tat, Rev and Nef proteins.]Altfeld M, Addo MM, Eldridge RL, Yu XG, Thomas S, Khatri A, Strick D, Phillips MN, Cohen GB, Islam SA, Kalams SA, Brander C, Goulder PJ, Rosenberg ES, Walker BD; HIV Study Collaboration.J Immunol. 2001 Sep 1;167(5):2743-52.
Vpr is preferentially targeted by CTL during HIV-1 infection.
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