Ting, David
eCommons Login: DTT1
first name: David
last name: Ting
coauthor of: Deshpande, Vikram
coauthor of: Maheswaran, Shyamala
coauthor of: Bhan, Irun
coauthor of: Haber, Daniel
coauthor of: Nieman, Linda
full name: David Tsai Ting, M.D.
has faculty rank: Associate Professor
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Person ID: 19429
person in primary position: Associate Professor of Medicine
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AR Expression in Breast Cancer CTCs Associates with Bone Metastases.
PubMed Identifier: 29453314
author list: Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran S
published in: Molecular cancer research : MCR
information resource reference: AR Expression in Breast Cancer CTCs Associates with Bone Metastases. Mol Cancer Res. 2018 04; 16(4):720-727.
journal title abbreviation: Mol Cancer Res
publication date: 2018-02-16T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.
PubMed Identifier: 23093251
author list: Miyamoto DT, Lee RJ, Stott SL, Ting DT, Wittner BS, Ulman M, Smas ME, Lord JB, Brannigan BW, Trautwein J, Bander NH, Wu CL, Sequist LV, Smith MR, Ramaswamy S, Toner M, Maheswaran S, Haber DA
published in: Cancer discovery
information resource reference: Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer. Cancer Discov. 2012 Nov; 2(11):995-1003.
journal title abbreviation: Cancer Discov
publication date: 2012-10-23T00:00:00
year: 2012
type: Academic Article
type: Article
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Amplification-free digital gene expression profiling from minute cell quantities.
PubMed Identifier: 20639869
author list: Ozsolak F, Ting DT, Wittner BS, Brannigan BW, Paul S, Bardeesy N, Ramaswamy S, Milos PM, Haber DA
published in: Nature methods
information resource reference: Amplification-free digital gene expression profiling from minute cell quantities. Nat Methods. 2010 Aug; 7(8):619-21.
journal title abbreviation: Nat Methods
publication date: 2010-07-18T00:00:00
year: 2010
type: Academic Article
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Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease.
PubMed Identifier: 30218669
author list: Bhan I, Mosesso K, Goyal L, Philipp J, Kalinich M, Franses JW, Choz M, Oklu R, Toner M, Maheswaran S, Haber DA, Zhu AX, Chung RT, Aryee M, Ting DT
published in: Gastroenterology
information resource reference: Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease. Gastroenterology. 2018 12; 155(6):2016-2018.e11.
journal title abbreviation: Gastroenterology
publication date: 2018-09-13T00:00:00
year: 2018
type: Academic Article
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In Reply.
PubMed Identifier: 30305416
author list: Franses JW, Ting DT
published in: The oncologist
information resource reference: In Reply. Oncologist. 2018 10; 23(10):e120.
journal title abbreviation: Oncologist
publication date: 2018-10-10T00:00:00
year: 2018
type: Academic Article
type: Article
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The histological diagnosis of IgG4-related disease on small biopsies: challenges and pitfalls.
PubMed Identifier: 30408214
author list: Arora K, Rivera M, Ting DT, Deshpande V
published in: Histopathology
information resource reference: The histological diagnosis of IgG4-related disease on small biopsies: challenges and pitfalls. Histopathology. 2019 Apr; 74(5):688-698.
journal title abbreviation: Histopathology
publication date: 2019-03-10T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.
PubMed Identifier: 30520819
author list: Kulkarni AS, Wojcik JB, Chougule A, Arora K, Chittampalli Y, Kurzawa P, Mullen JT, Chebib I, Nielsen GP, Rivera MN, Ting DT, Deshpande V
published in: The American journal of surgical pathology
information resource reference: MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression. Am J Surg Pathol. 2019 04; 43(4):446-454.
journal title abbreviation: Am J Surg Pathol
publication date: 2019-04-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.
PubMed Identifier: 30642914
author list: Hernandez-Barco YG, Bardeesy N, Ting DT
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity. Clin Cancer Res. 2019 04 01; 25(7):2027-2029.
journal title abbreviation: Clin Cancer Res
publication date: 2019-01-14T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

A tumor-specific endogenous repetitive element is induced by herpesviruses.
PubMed Identifier: 30626867
author list: Nogalski MT, Solovyov A, Kulkarni AS, Desai N, Oberstein A, Levine AJ, Ting DT, Shenk T, Greenbaum BD
published in: Nature communications
information resource reference: A tumor-specific endogenous repetitive element is induced by herpesviruses. Nat Commun. 2019 01 09; 10(1):90.
journal title abbreviation: Nat Commun
publication date: 2019-01-09T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Quasimesenchymal phenotype predicts systemic metastasis in pancreatic ductal adenocarcinoma.
PubMed Identifier: 30683911
author list: Mahadevan KK, Arora KS, Amzallag A, Williams E, Kulkarni AS, Fernandez-Del Castillo C, Lillemoe KD, Bardeesy N, Hong TS, Ferrone CR, Ting DT, Deshpande V
published in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
information resource reference: Quasimesenchymal phenotype predicts systemic metastasis in pancreatic ductal adenocarcinoma. Mod Pathol. 2019 06; 32(6):844-854.
journal title abbreviation: Mod Pathol
publication date: 2019-01-25T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs).
PubMed Identifier: 30670493
author list: Cai L, Michelakos T, Deshpande V, Arora KS, Yamada T, Ting DT, Taylor MS, Castillo CF, Warshaw AL, Lillemoe KD, Ferrone S, Ferrone CR
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs). Clin Cancer Res. 2019 04 15; 25(8):2644-2655.
journal title abbreviation: Clin Cancer Res
publication date: 2019-01-22T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

A Code of Mono-phosphorylation Modulates the Function of RB.
PubMed Identifier: 30711375
author list: Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ
published in: Molecular cell
information resource reference: A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019 03 07; 73(5):985-1000.e6.
journal title abbreviation: Mol Cell
publication date: 2019-01-30T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy.
PubMed Identifier: 30755500
author list: Mitra D, Horick NK, Brackett DG, Mouw KW, Hornick JL, Ferrone S, Hong TS, Mamon H, Clark JW, Parikh AR, Allen JN, Ryan DP, Ting DT, Deshpande V, Wo JY
published in: The oncologist
information resource reference: High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy. Oncologist. 2019 06; 24(6):e275-e283.
journal title abbreviation: Oncologist
publication date: 2019-02-12T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer Progression
end date: 2024-01-31
principal investigator name: MOSTOSLAVSKY, RAUL
start date: 2019-02-19
type: Grant
sponsor award id: R01CA235412

COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis.
PubMed Identifier: 30819896
author list: Zheng Y, Comaills V, Burr R, Boulay G, Miyamoto DT, Wittner BS, Emmons E, Sil S, Koulopoulos MW, Broderick KT, Tai E, Rengarajan S, Kulkarni AS, Shioda T, Wu CL, Ramaswamy S, Ting DT, Toner M, Rivera MN, Maheswaran S, Haber DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5223-5232.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2019-02-28T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function.
PubMed Identifier: 30869654
author list: Boroughs AC, Larson RC, Choi BD, Bouffard AA, Riley LS, Schiferle E, Kulkarni AS, Cetrulo CL, Ting D, Blazar BR, Demehri S, Maus MV
published in: JCI insight
information resource reference: Chimeric antigen receptor costimulation domains modulate human regulatory T cell function. JCI Insight. 2019 03 14; 5.
journal title abbreviation: JCI Insight
publication date: 2019-03-14T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

In Situ Hybridization
MeSH DescriptorUI: D017403
MeSH semantic group name: Procedures
number of authors: 802
number of publications: 1808
uniqueness weight: 0.74872
type: Concept

Carcinoma, Pancreatic Ductal
MeSH DescriptorUI: D021441
MeSH semantic group name: Disorders
number of authors: 530
number of publications: 1928
uniqueness weight: 0.424804
type: Concept

Tumor Microenvironment
MeSH DescriptorUI: D059016
MeSH semantic group name: Phenomena
number of authors: 1514
number of publications: 4563
uniqueness weight: 0.36893
type: Concept

Pancreatic Neoplasms
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MeSH semantic group name: Disorders
number of authors: 1283
number of publications: 5732
uniqueness weight: 0.273822
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Neoplastic Cells, Circulating
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MeSH semantic group name: Anatomy
number of authors: 362
number of publications: 949
uniqueness weight: 0.605659
type: Concept

MGH Cancer Center Research
type: Division
type: Organization

Reply.
PubMed Identifier: 30928436
author list: Bhan I, Aryee M, Ting DT
published in: Gastroenterology
information resource reference: Reply. Gastroenterology. 2019 05; 156(6):1933-1934.
journal title abbreviation: Gastroenterology
publication date: 2019-03-27T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Giant Cell Lesions of the Maxillofacial Skeleton Express RANKL by RNA In Situ Hybridization Regardless of Histologic Pattern.
PubMed Identifier: 30998511
author list: Stagner AM, Sajed DP, Nielsen GP, Ebb DH, Faquin WC, Chebib I, Rivera MN, Ting DT, Resnick CM, Peacock ZS, Kaban LB, Deshpande V
published in: The American journal of surgical pathology
information resource reference: Giant Cell Lesions of the Maxillofacial Skeleton Express RANKL by RNA In Situ Hybridization Regardless of Histologic Pattern. Am J Surg Pathol. 2019 06; 43(6):819-826.
journal title abbreviation: Am J Surg Pathol
publication date: 2019-06-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
PubMed Identifier: 31040255
author list: Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Zou L, Ting DT, Catenacci DV, Chao J, Fakih M, Klempner SJ, Ross JS, Frampton GM, Miller VA, Ali SM, Schrock AB
published in: The oncologist
information resource reference: Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. Oncologist. 2019 10; 24(10):1340-1347.
journal title abbreviation: Oncologist
publication date: 2019-04-30T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Emeritus
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Medicine
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Pathology
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Radiation Oncology
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Surgery
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Gastroenterology
type: Division
type: Organization

Hematology/Oncology
type: Division
type: Organization

Beth Israel Deaconess Medical Center
type: Organization

Harvard Medical School
type: Organization

Massachusetts General Hospital
type: Organization

Haber, Daniel
eCommons Login: DAH2
first name: Daniel
last name: Haber
full name: Daniel Arie Haber, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.37730000000000
longitude: -71.05250000000000
Person ID: 10825
person in primary position: Kurt J. Isselbacher Professor of Oncology
type: Agent
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preferred title: Kurt J. Isselbacher Professor of Oncology

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.
PubMed Identifier: 31109923
author list: Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leschiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, Reyes S, Sagara T, Otsuki S, Nadres B, Shahzade HA, Dey-Guha I, Fetter IJ, Baiev I, Van Seventer EE, Murphy JE, Ferrone CR, Tanabe KK, Deshpande V, Harding JJ, Yaeger R, Kelley RK, Bardelli A, Iafrate AJ, Hahn WC, Benes CH, Ting DT, Hirai H, Getz G, Juric D, Zhu AX, Corcoran RB, Bardeesy N
published in: Cancer discovery
information resource reference: TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma. Cancer Discov. 2019 08; 9(8):1064-1079.
journal title abbreviation: Cancer Discov
publication date: 2019-05-20T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
PubMed Identifier: 31145418
author list: Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS
published in: JAMA oncology
information resource reference: Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 Jul 01; 5(7):1020-1027.
journal title abbreviation: JAMA Oncol
publication date: 2019-07-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

McAfee, Steven
eCommons Login: SLM3
first name: Steven
last name: McAfee
full name: Steven Lawrence McAfee, M.D.
has faculty rank: Assistant Professor
latitude: 42.36241700000000
longitude: -71.06893700000000
Person ID: 33906
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.
PubMed Identifier: 31155233
author list: Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, Misale S, Di Pilato M, Ebright RY, Karabacak MN, Kulkarni AS, Liu A, Vincent Jordan N, Franses JW, Philipp J, Kreuzer J, Desai N, Arora KS, Rajurkar M, Horwitz E, Neyaz A, Tai E, Magnus NKC, Vo KD, Yashaswini CN, Marangoni F, Boukhali M, Fatherree JP, Damon LJ, Xega K, Desai R, Choz M, Bersani F, Langenbucher A, Thapar V, Morris R, Wellner UF, Schilling O, Lawrence MS, Liss AS, Rivera MN, Deshpande V, Benes CH, Maheswaran S, Haber DA, Fernandez-Del-Castillo C, Ferrone CR, Haas W, Aryee MJ, Ting DT
published in: Cell
information resource reference: Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019 06 27; 178(1):160-175.e27.
journal title abbreviation: Cell
publication date: 2019-05-30T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Isakoff, Steven
eCommons Login: SJI1
first name: Steven
last name: Isakoff
full name: Steven Jay Isakoff, M.D., Ph.D.
has faculty rank: Assistant Professor
latitude: 42.36241700000000
longitude: -71.06893700000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 3191
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Mino-Kenudson, Mari
eCommons Login: MM4
first name: Mari
last name: Mino-Kenudson
full name: Mari Mino-Kenudson, M.D.
has faculty rank: Full Professor
latitude: 42.36241700000000
longitude: -71.06893700000000
Person ID: 38437
person in primary position: Professor of Pathology
type: Agent
type: Person
preferred title: Professor of Pathology

Deshpande, Vikram
eCommons Login: VD5
first name: Vikram
last name: Deshpande
full name: Vikram Deshpande, M.B.,B.S.
has faculty rank: Full Professor
latitude: 42.36241700000000
longitude: -71.06893700000000
Person ID: 27585
person in primary position: Professor of Pathology
type: Agent
type: Person
preferred title: Professor of Pathology

selected publications
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Lillemoe, Keith
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Flaherty, Keith
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Hong, Theodore
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Maheswaran, Shyamala
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Blaszkowsky, Lawrence
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Abramson, Jeremy
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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.
PubMed Identifier: 31501609
author list: Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, Van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, Danysh BP, de la Cruz FF, Fetter IJ, Nadres B, Shahzade HA, Allen JN, Blaszkowsky LS, Clark JW, Giantonio B, Murphy JE, Nipp RD, Roeland E, Ryan DP, Weekes CD, Kwak EL, Faris JE, Wo JY, Aguet F, Dey-Guha I, Hazar-Rethinam M, Dias-Santagata D, Ting DT, Zhu AX, Hong TS, Golub TR, Iafrate AJ, Adalsteinsson VA, Bardelli A, Parida L, Juric D, Getz G, Corcoran RB
published in: Nature medicine
information resource reference: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 09; 25(9):1415-1421.
journal title abbreviation: Nat Med
publication date: 2019-09-09T00:00:00
year: 2019
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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21.
PubMed Identifier: 31533034
author list: Abels ER, Maas SLN, Nieland L, Wei Z, Cheah PS, Tai E, Kolsteeg CJ, Dusoswa SA, Ting DT, Hickman S, El Khoury J, Krichevsky AM, Broekman MLD, Breakefield XO
published in: Cell reports
information resource reference: Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21. Cell Rep. 2019 09 17; 28(12):3105-3119.e7.
journal title abbreviation: Cell Rep
publication date: 2019-09-17T00:00:00
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Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.
PubMed Identifier: 31745334
author list: Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, Van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, Danysh BP, de la Cruz FF, Fetter IJ, Nadres B, Shahzade HA, Allen JN, Blaszkowsky LS, Clark JW, Giantonio B, Murphy JE, Nipp RD, Roeland E, Ryan DP, Weekes CD, Kwak EL, Faris JE, Wo JY, Aguet F, Dey-Guha I, Hazar-Rethinam M, Dias-Santagata D, Ting DT, Zhu AX, Hong TS, Golub TR, Iafrate AJ, Adalsteinsson VA, Bardelli A, Parida L, Juric D, Getz G, Corcoran RB
published in: Nature medicine
information resource reference: Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 Dec; 25(12):1949.
journal title abbreviation: Nat Med
publication date: 2019-12-01T00:00:00
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Kurt J. Isselbacher Professor of Oncology
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Assistant Professor of Medicine
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Assistant Professor of Medicine
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Professor of Pathology
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Instructor in Medicine
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Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma.
PubMed Identifier: 31843922
author list: Porter RL, Magnus NKC, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni AS, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M, Vo KD, Nieman L, Liss AS, Deshpande V, Lawrence MS, Maheswaran S, Fernandez-Del Castillo C, Hong TS, Ryan DP, O'Dwyer PJ, Drebin JA, Ferrone CR, Haber DA, Ting DT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26835-26845.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2019-12-16T00:00:00
year: 2019
type: Academic Article
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Pancreatic ductal adenocarcinoma: tumour regression grading following neoadjuvant FOLFIRINOX and radiation.
PubMed Identifier: 32031712
author list: Neyaz A, Tabb ES, Shih A, Zhao Q, Shroff S, Taylor MS, Rickelt S, Wo JY, Fernandez-Del Castillo C, Qadan M, Hong TS, Lillemoe KD, Ting DT, Ferrone CR, Deshpande V
published in: Histopathology
information resource reference: Pancreatic ductal adenocarcinoma: tumour regression grading following neoadjuvant FOLFIRINOX and radiation. Histopathology. 2020 Jul; 77(1):35-45.
journal title abbreviation: Histopathology
publication date: 2020-06-01T00:00:00
year: 2020
type: Academic Article
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Somatic Mutations in Liver Disease: Adaptation Without Carcinogenesis?
PubMed Identifier: 32034958
author list: Bhan I, Ting DT
published in: Hepatology (Baltimore, Md.)
information resource reference: Somatic Mutations in Liver Disease: Adaptation Without Carcinogenesis? Hepatology. 2020 06; 71(6):2162-2163.
journal title abbreviation: Hepatology
publication date: 2020-06-01T00:00:00
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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis.
PubMed Identifier: 32029688
author list: Ebright RY, Lee S, Wittner BS, Niederhoffer KL, Nicholson BT, Bardia A, Truesdell S, Wiley DF, Wesley B, Li S, Mai A, Aceto N, Vincent-Jordan N, Szabolcs A, Chirn B, Kreuzer J, Comaills V, Kalinich M, Haas W, Ting DT, Toner M, Vasudevan S, Haber DA, Maheswaran S, Micalizzi DS
published in: Science (New York, N.Y.)
information resource reference: Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science. 2020 03 27; 367(6485):1468-1473.
journal title abbreviation: Science
publication date: 2020-02-06T00:00:00
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Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.
PubMed Identifier: 32075753
author list: Lucero R, Zappulli V, Sammarco A, Murillo OD, Cheah PS, Srinivasan S, Tai E, Ting DT, Wei Z, Roth ME, Laurent LC, Krichevsky AM, Breakefield XO, Milosavljevic A
published in: Cell reports
information resource reference: Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells. Cell Rep. 2020 02 18; 30(7):2065-2074.e4.
journal title abbreviation: Cell Rep
publication date: 2020-02-18T00:00:00
year: 2020
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Glioblastoma hijacks microglial gene expression to support tumor growth.
PubMed Identifier: 32299465
author list: Maas SLN, Abels ER, Van De Haar LL, Zhang X, Morsett L, Sil S, Guedes J, Sen P, Prabhakar S, Hickman SE, Lai CP, Ting DT, Breakefield XO, Broekman MLD, El Khoury J
published in: Journal of neuroinflammation
information resource reference: Glioblastoma hijacks microglial gene expression to support tumor growth. J Neuroinflammation. 2020 Apr 16; 17(1):120.
journal title abbreviation: J Neuroinflammation
publication date: 2020-04-16T00:00:00
year: 2020
type: Academic Article
type: Article
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Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy.
PubMed Identifier: 32497200
author list: Michelakos T, Cai L, Villani V, Sabbatino F, Kontos F, Fernández-Del Castillo C, Yamada T, Neyaz A, Taylor MS, Deshpande V, Kurokawa T, Ting DT, Qadan M, Weekes CD, Allen JN, Clark JW, Hong TS, Ryan DP, Wo JY, Warshaw AL, Lillemoe KD, Ferrone S, Ferrone CR
published in: Journal of the National Cancer Institute
information resource reference: Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy. J Natl Cancer Inst. 2021 02 01; 113(2):182-191.
journal title abbreviation: J Natl Cancer Inst
publication date: 2021-02-01T00:00:00
year: 2021
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GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.
PubMed Identifier: 32555306
author list: Abels ER, Maas SLN, Tai E, Ting DT, Broekman MLD, Breakefield XO, El Khoury J
published in: Scientific reports
information resource reference: GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma. Sci Rep. 2020 06 18; 10(1):9898.
journal title abbreviation: Sci Rep
publication date: 2020-06-18T00:00:00
year: 2020
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Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.
PubMed Identifier: 32620742
author list: Franses JW, Philipp J, Missios P, Bhan I, Liu A, Yashaswini C, Tai E, Zhu H, Ligorio M, Nicholson B, Tassoni EM, Desai N, Kulkarni AS, Szabolcs A, Hong TS, Liss AS, Fernandez-Del Castillo C, Ryan DP, Maheswaran S, Haber DA, Daley GQ, Ting DT
published in: Nature communications
information resource reference: Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target. Nat Commun. 2020 07 03; 11(1):3303.
journal title abbreviation: Nat Commun
publication date: 2020-07-03T00:00:00
year: 2020
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Reverse transcriptase inhibitor effects on the mobilome of colon cancer
end date: 2025-06-30
principal investigator name: TING, DAVID TSAI
start date: 2019-07-01
type: Grant
sponsor award id: R01CA240924

Co-Principal Investigator
type: Researcher Role
researcher role of: Ting, David
contributes to: Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer Progression

Principal Investigator
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researcher role of: Ting, David
contributes to: Reverse transcriptase inhibitor effects on the mobilome of colon cancer

Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.
PubMed Identifier: 32657929
author list: Seppälä TT, Zimmerman JW, Sereni E, Plenker D, Suri R, Rozich N, Blair A, Thomas DL, Teinor J, Javed A, Patel H, Cameron JL, Burns WR, He J, Tuveson DA, Jaffee EM, Eshleman J, Szabolcs A, Ryan DP, Ting DT, Wolfgang CL, Burkhart RA
published in: Annals of surgery
information resource reference: Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer. Ann Surg. 2020 09 01; 272(3):427-435.
journal title abbreviation: Ann Surg
publication date: 2020-09-01T00:00:00
year: 2020
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Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer.
PubMed Identifier: 32675550
author list: Honselmann KC, Pergolini I, Castillo CF, Deshpande V, Ting D, Taylor MS, Bolm L, Qadan M, Wellner U, Sandini M, Bausch D, Warshaw AL, Lillemoe KD, Keck T, Ferrone CR
published in: Annals of surgery
information resource reference: Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer. Ann Surg. 2020 08; 272(2):357-365.
journal title abbreviation: Ann Surg
publication date: 2020-08-01T00:00:00
year: 2020
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Professor of Surgery
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Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection.
PubMed Identifier: 32766600
author list: Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A, Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD, Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V
published in: medRxiv : the preprint server for health sciences
information resource reference: Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection. medRxiv. 2020 Aug 02.
journal title abbreviation: medRxiv
publication date: 2020-08-02T00:00:00
year: 2020
type: Academic Article
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SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers.
PubMed Identifier: 32741970
author list: Hecht JL, Quade B, Deshpande V, Mino-Kenudson M, Ting DT, Desai N, Dygulska B, Heyman T, Salafia C, Shen D, Bates SV, Roberts DJ
published in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
information resource reference: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol. 2020 11; 33(11):2092-2103.
journal title abbreviation: Mod Pathol
publication date: 2020-08-02T00:00:00
year: 2020
type: Academic Article
type: Article
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Comparison of RNA In Situ Hybridization and Immunohistochemistry Techniques for the Detection and Localization of SARS-CoV-2 in Human Tissues.
PubMed Identifier: 32826529
author list: Massoth LR, Desai N, Szabolcs A, Harris CK, Neyaz A, Crotty R, Chebib I, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V
published in: The American journal of surgical pathology
information resource reference: Comparison of RNA In Situ Hybridization and Immunohistochemistry Techniques for the Detection and Localization of SARS-CoV-2 in Human Tissues. Am J Surg Pathol. 2021 01; 45(1):14-24.
journal title abbreviation: Am J Surg Pathol
publication date: 2021-01-01T00:00:00
year: 2021
type: Academic Article
type: Article
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Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer.
PubMed Identifier: 32873625
author list: Honselmann KC, Finetti P, Birnbaum DJ, Monsalve CS, Wellner UF, Begg SKS, Nakagawa A, Hank T, Li A, Goldsworthy MA, Sharma H, Bertucci F, Birnbaum D, Tai E, Ligorio M, Ting DT, Schilling O, Biniossek ML, Bronsert P, Ferrone CR, Keck T, Mino-Kenudson M, Lillemoe KD, Warshaw AL, Fernández-Del Castillo C, Liss AS
published in: Molecular cancer research : MCR
information resource reference: Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer. Mol Cancer Res. 2020 12; 18(12):1889-1902.
journal title abbreviation: Mol Cancer Res
publication date: 2020-09-01T00:00:00
year: 2020
type: Academic Article
type: Article
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IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.
PubMed Identifier: 32923170
author list: Richardson LG, Nieman LT, Stemmer-Rachamimov AO, Zheng XS, Stafford K, Nagashima H, Miller JJ, Kiyokawa J, Ting DT, Wakimoto H, Cahill DP, Choi BD, Curry WT
published in: Oncoimmunology
information resource reference: IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice. Oncoimmunology. 2020 08 20; 9(1):1806662.
journal title abbreviation: Oncoimmunology
publication date: 2020-08-20T00:00:00
year: 2020
type: Academic Article
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Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment.
PubMed Identifier: 32957515
author list: Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ, Brekken R, Ting DT, Ligorio M
published in: Cancers
information resource reference: Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Cancers (Basel). 2020 Sep 17; 12(9).
journal title abbreviation: Cancers (Basel)
publication date: 2020-09-17T00:00:00
year: 2020
type: Academic Article
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Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma.
PubMed Identifier: 33086310
author list: Chawla A, Qadan M, Castillo CF, Wo JY, Allen JN, Clark JW, Murphy JE, Catalano OA, Ryan DP, Ting DT, Deshpande V, Weekes CD, Parikh A, Lillemoe KD, Hong TS, Ferrone CR
published in: Annals of surgery
information resource reference: Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma. Ann Surg. 2022 11 01; 276(5):e502-e509.
journal title abbreviation: Ann Surg
publication date: 2020-10-19T00:00:00
year: 2020
type: Academic Article
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The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.
PubMed Identifier: 33203734
author list: Hong X, Roh W, Sullivan RJ, Wong KHK, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley B, Horwitz E, Boland GM, Marvin DL, Bonesteel T, Lu C, Aguet F, Burr R, Freeman SS, Parida L, Calhoun K, Jewett MK, Nieman LT, Hacohen N, Näär AM, Ting DT, Toner M, Stott SL, Getz G, Maheswaran S, Haber DA
published in: Cancer discovery
information resource reference: The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis. Cancer Discov. 2021 03; 11(3):678-695.
journal title abbreviation: Cancer Discov
publication date: 2020-11-17T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection.
PubMed Identifier: 33298930
author list: Desai N, Neyaz A, Szabolcs A, Shih AR, Chen JH, Thapar V, Nieman LT, Solovyov A, Mehta A, Lieb DJ, Kulkarni AS, Jaicks C, Xu KH, Raabe MJ, Pinto CJ, Juric D, Chebib I, Colvin RB, Kim AY, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD, Hacohen N, Lagana SM, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V
published in: Nature communications
information resource reference: Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. Nat Commun. 2020 12 09; 11(1):6319.
journal title abbreviation: Nat Commun
publication date: 2020-12-09T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

HIF1A signaling selectively supports proliferation of breast cancer in the brain.
PubMed Identifier: 33298946
author list: Ebright RY, Zachariah MA, Micalizzi DS, Wittner BS, Niederhoffer KL, Nieman LT, Chirn B, Wiley DF, Wesley B, Shaw B, Nieblas-Bedolla E, Atlas L, Szabolcs A, Iafrate AJ, Toner M, Ting DT, Brastianos PK, Haber DA, Maheswaran S
published in: Nature communications
information resource reference: HIF1A signaling selectively supports proliferation of breast cancer in the brain. Nat Commun. 2020 12 09; 11(1):6311.
journal title abbreviation: Nat Commun
publication date: 2020-12-09T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia.
PubMed Identifier: 33464729
author list: Neyaz A, Odze RD, Rickelt S, Nieman LT, Bledsoe JR, Mahadevan KK, Arora K, Jeck WR, Taylor MS, Gala M, Patil DT, Yilmaz OH, Rivera MN, Ting DT, Deshpande V
published in: Clinical and translational gastroenterology
information resource reference: LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia. Clin Transl Gastroenterol. 2020 12 22; 12(1):e00272.
journal title abbreviation: Clin Transl Gastroenterol
publication date: 2020-12-22T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Conditional Survival in Resected Pancreatic Ductal Adenocarcinoma Patients Treated with Total Neoadjuvant Therapy.
PubMed Identifier: 33501584
author list: Michelakos T, Sekigami Y, Kontos F, Fernández-Del Castillo C, Qadan M, Deshpande V, Ting DT, Clark JW, Weekes CD, Parikh A, Ryan DP, Wo JY, Hong TS, Allen JN, Catalano O, Warshaw AL, Lillemoe KD, Ferrone CR
published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
information resource reference: Conditional Survival in Resected Pancreatic Ductal Adenocarcinoma Patients Treated with Total Neoadjuvant Therapy. J Gastrointest Surg. 2021 11; 25(11):2859-2870.
journal title abbreviation: J Gastrointest Surg
publication date: 2021-01-26T00:00:00
year: 2021
type: Academic Article
type: Article
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type: Information Resource

A Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor Immunity
end date: 2025-08-31
principal investigator name: GREENBAUM, BENJAMIN
start date: 2020-09-15
type: Grant
sponsor award id: U01CA228963

Co-Principal Investigator
type: Researcher Role
researcher role of: Ting, David
contributes to: A Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor Immunity

Transcriptomic Analysis of Laser Capture Microdissected Tumors Reveals Cancer- and Stromal-Specific Molecular Subtypes of Pancreatic Ductal Adenocarcinoma.
PubMed Identifier: 33547202
author list: Birnbaum DJ, Begg SKS, Finetti P, Vanderburg C, Kulkarni AS, Neyaz A, Hank T, Tai E, Deshpande V, Bertucci F, Birnbaum D, Lillemoe KD, Warshaw AL, Mino-Kenudson M, Fernandez-Del Castillo C, Ting DT, Liss AS
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Transcriptomic Analysis of Laser Capture Microdissected Tumors Reveals Cancer- and Stromal-Specific Molecular Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2021 04 15; 27(8):2314-2325.
journal title abbreviation: Clin Cancer Res
publication date: 2021-02-05T00:00:00
year: 2021
type: Academic Article
type: Article
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type: Information Resource

Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies.
PubMed Identifier: 33653818
author list: Guo JA, Hoffman HI, Weekes CD, Zheng L, Ting DT, Hwang WL
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies. Clin Cancer Res. 2021 07 15; 27(14):3825-3833.
journal title abbreviation: Clin Cancer Res
publication date: 2021-03-02T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Massachusetts General Hospital

https://connects.catalyst.harvard.edu/Profiles/profile/184207909
PubMed Identifier: 34364845
author list: Roberts DJ, Edlow AG, Romero RJ, Coyne CB, Ting DT, Hornick JL, Zaki SR, Das Adhikari U, Serghides L, Gaw SL, Metz TD
published in: American journal of obstetrics and gynecology
information resource reference: A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop. Am J Obstet Gynecol. 2021 12; 225(6):593.e1-593.e9.
journal title abbreviation: Am J Obstet Gynecol
publication date: 2021-08-05T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource
label: A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.

Spontaneous Immune-Mediated Regression of Hepatocellular Carcinoma With High Tumor Mutational Burden.
PubMed Identifier: 34585041
author list: Franses JW, Bhan I, Pankaj A, Ting DT, Deshpande V, Tanabe K
published in: JCO precision oncology
information resource reference: Spontaneous Immune-Mediated Regression of Hepatocellular Carcinoma With High Tumor Mutational Burden. JCO Precis Oncol. 2021; 5.
journal title abbreviation: JCO Precis Oncol
publication date: 2021-06-17T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides.
PubMed Identifier: 34650218
author list: Gill T, Wang H, Bandaru R, Lawlor M, Lu C, Nieman LT, Tao J, Zhang Y, Anderson DG, Ting DT, Chen X, Bradner JE, Ott CJ
published in: Oncogene
information resource reference: Selective targeting of MYC mRNA by stabilized antisense oligonucleotides. Oncogene. 2021 11; 40(47):6527-6539.
journal title abbreviation: Oncogene
publication date: 2021-10-14T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.
PubMed Identifier: 34779407
author list: Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ
published in: The Journal of clinical investigation
information resource reference: LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. J Clin Invest. 2021 11 15; 131(22).
journal title abbreviation: J Clin Invest
publication date: 2021-11-15T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition.
PubMed Identifier: 35045985
author list: Karabacak NM, Zheng Y, Dubash TD, Burr R, Micalizzi DS, Wittner BS, Lin M, Wiley DF, Comaills V, Emmons E, Niederhoffer KL, Ho U, Ukleja J, Che D, Stowe H, Nieman LT, Haas W, Stott SL, Lawrence MS, Ting DT, Miyamoto DT, Haber DA, Toner M, Maheswaran S
published in: Cancer research
information resource reference: Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition. Cancer Res. 2022 03 15; 82(6):1084-1097.
journal title abbreviation: Cancer Res
publication date: 2022-03-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial.
PubMed Identifier: 35122060
author list: Parikh AR, Szabolcs A, Allen JN, Clark JW, Wo JY, Raabe M, Thel H, Hoyos D, Mehta A, Arshad S, Lieb DJ, Drapek LC, Blaszkowsky LS, Giantonio BJ, Weekes CD, Zhu AX, Goyal L, Nipp RD, Dubois JS, Van Seventer EE, Foreman BE, Matlack LE, Ly L, Meurer JA, Hacohen N, Ryan DP, Yeap BY, Corcoran RB, Greenbaum BD, Ting DT, Hong TS
published in: Nature cancer
information resource reference: Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial. Nat Cancer. 2021 11; 2(11):1124-1135.
journal title abbreviation: Nat Cancer
publication date: 2021-11-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer.
PubMed Identifier: 35320348
author list: Rajurkar M, Parikh AR, Solovyov A, You E, Kulkarni AS, Chu C, Xu KH, Jaicks C, Taylor MS, Wu C, Alexander KA, Good CR, Szabolcs A, Gerstberger S, Tran AV, Xu N, Ebright RY, Van Seventer EE, Vo KD, Tai EC, Lu C, Joseph-Chazan J, Raabe MJ, Nieman LT, Desai N, Arora KS, Ligorio M, Thapar V, Cohen L, Garden PM, Senussi Y, Zheng H, Allen JN, Blaszkowsky LS, Clark JW, Goyal L, Wo JY, Ryan DP, Corcoran RB, Deshpande V, Rivera MN, Aryee MJ, Hong TS, Berger SL, Walt DR, Burns KH, Park PJ, Greenbaum BD, Ting DT
published in: Cancer discovery
information resource reference: Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer. Cancer Discov. 2022 06 02; 12(6):1462-1481.
journal title abbreviation: Cancer Discov
publication date: 2022-06-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response.
PubMed Identifier: 35363262
author list: Seppälä TT, Zimmerman JW, Suri R, Zlomke H, Ivey GD, Szabolcs A, Shubert CR, Cameron JL, Burns WR, Lafaro KJ, He J, Wolfgang CL, Zou YS, Zheng L, Tuveson DA, Eshlemann JR, Ryan DP, Kimmelman AC, Hong TS, Ting DT, Jaffee EM, Burkhart RA
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response. Clin Cancer Res. 2022 08 02; 28(15):3296-3307.
journal title abbreviation: Clin Cancer Res
publication date: 2022-08-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Correlation of clinical, pathologic, and genetic parameters with intratumoral immune milieu in mucinous adenocarcinoma of the colon.
PubMed Identifier: 35590108
author list: Neyaz A, Pankaj A, Crabbe A, Rickelt S, Leijssen L, Dinaux A, Taylor M, Shroff SG, Crotty R, Zhang ML, Yilmaz OH, Yilmaz O, Patil DT, Parikh AR, Ting DT, Berger D, Deshpande V
published in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
information resource reference: Correlation of clinical, pathologic, and genetic parameters with intratumoral immune milieu in mucinous adenocarcinoma of the colon. Mod Pathol. 2022 11; 35(11):1723-1731.
journal title abbreviation: Mod Pathol
publication date: 2022-05-19T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype.
PubMed Identifier: 35708912
author list: Porter RL, Sun S, Flores MN, Berzolla E, You E, Phillips IE, Kc N, Desai N, Tai EC, Szabolcs A, Lang ER, Pankaj A, Raabe MJ, Thapar V, Xu KH, Nieman LT, Rabe DC, Kolin DL, Stover EH, Pepin D, Stott SL, Deshpande V, Liu JF, Solovyov A, Matulonis UA, Greenbaum BD, Ting DT
published in: The Journal of clinical investigation
information resource reference: Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype. J Clin Invest. 2022 08 15; 132(16).
journal title abbreviation: J Clin Invest
publication date: 2022-08-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
PubMed Identifier: 35902743
author list: Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
published in: Nature genetics
information resource reference: Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022 08; 54(8):1178-1191.
journal title abbreviation: Nat Genet
publication date: 2022-07-28T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Programmed death-ligand 1 expression in the immune compartment of colon carcinoma.
PubMed Identifier: 35773332
author list: Yilmaz O, Pankaj A, Neyez A, Rickelt S, Taylor M, Lang ER, Leijsen L, Dinaux A, Shroff SG, Crotty R, Zhang ML, Cerda S, Zhao Q, Ferrone C, Ting DT, Patil DT, Yilmaz O, Berger D, Deshpande V
published in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
information resource reference: Programmed death-ligand 1 expression in the immune compartment of colon carcinoma. Mod Pathol. 2022 11; 35(11):1740-1748.
journal title abbreviation: Mod Pathol
publication date: 2022-06-30T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Supportive Oncology Care at Home Intervention for Patients With Pancreatic Cancer.
PubMed Identifier: 35830625
author list: Nipp RD, Gaufberg E, Vyas C, Azoba C, Qian CL, Jaggers J, Weekes CD, Allen JN, Roeland EJ, Parikh AR, Miller L, Wo JY, Smith MH, Brown PMC, Shulman E, Fernandez-Del Castillo C, Kimmelman AC, Ting D, Hong TS, Greer JA, Ryan DP, Temel JS, El-Jawahri A
published in: JCO oncology practice
information resource reference: Supportive Oncology Care at Home Intervention for Patients With Pancreatic Cancer. JCO Oncol Pract. 2022 10; 18(10):e1587-e1593.
journal title abbreviation: JCO Oncol Pract
publication date: 2022-07-13T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer.
PubMed Identifier: 35508175
author list: Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, Adli M
published in: Developmental cell
information resource reference: ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer. Dev Cell. 2022 06 06; 57(11):1331-1346.e9.
journal title abbreviation: Dev Cell
publication date: 2022-05-03T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular Basis of Extramural Vascular Invasion (EMVI) in Colorectal Carcinoma.
PubMed Identifier: 35917013
author list: Sonal S, Deshpande V, Ting DT, Cusack JC, Parikh AR, Neyaz A, Pankaj A, Taylor MS, Dinaux AM, Leijssen LGJ, Boudreau C, Locascio JJ, Kunitake H, Goldstone RN, Bordeianou LG, Cauley CE, Ricciardi R, Berger DL
published in: Annals of surgical oncology
information resource reference: Molecular Basis of Extramural Vascular Invasion (EMVI) in Colorectal Carcinoma. Ann Surg Oncol. 2022 Nov; 29(12):7372-7382.
journal title abbreviation: Ann Surg Oncol
publication date: 2022-08-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

FGFR mRNA Expression in Cholangiocarcinoma and Its Correlation with FGFR2 Fusion Status and Immune Signatures.
PubMed Identifier: 36190545
author list: Sridharan V, Neyaz A, Chogule A, Baiev I, Reyes S, Barr Fritcher EG, Lennerz JK, Sukov W, Kipp B, Ting DT, Deshpande V, Goyal L
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: FGFR mRNA Expression in Cholangiocarcinoma and Its Correlation with FGFR2 Fusion Status and Immune Signatures. Clin Cancer Res. 2022 12 15; 28(24):5431-5439.
journal title abbreviation: Clin Cancer Res
publication date: 2022-12-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody.
PubMed Identifier: 36256815
author list: Micalizzi DS, Che D, Nicholson BT, Edd JF, Desai N, Lang ER, Toner M, Maheswaran S, Ting DT, Haber DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2209563119.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2022-10-18T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Gastroenterology
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Massachusetts General Hospital

Immunological and Clinico-Molecular Features of Tumor Border Configuration in Colorectal Cancer.
PubMed Identifier: 36519916
author list: Sonal S, Deshpande V, Ting DT, Neyaz A, Pankaj A, Taylor MS, Dinaux AM, Leijssen LG, Boudreau C, Berger DL
published in: Journal of the American College of Surgeons
information resource reference: Immunological and Clinico-Molecular Features of Tumor Border Configuration in Colorectal Cancer. J Am Coll Surg. 2023 01 01; 236(1):126-134.
journal title abbreviation: J Am Coll Surg
publication date: 2022-12-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Quantitative p53 immunostaining aids in the detection of prevalent dysplasia.
PubMed Identifier: 36823143
author list: Neyaz A, Rickelt S, Yilmaz OH, Parrack PH, Lu C, Yilmaz O, Wu EY, Choi WT, Gala M, Ting DT, Odze RD, Patil DT, Deshpande V
published in: Journal of clinical pathology
information resource reference: Quantitative p53 immunostaining aids in the detection of prevalent dysplasia. J Clin Pathol. 2023 Sep; 76(9):582-590.
journal title abbreviation: J Clin Pathol
publication date: 2023-02-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

TGF-ß in the microenvironment induces a physiologically occurring immune-suppressive senescent state.
PubMed Identifier: 36821441
author list: Matsuda S, Revandkar A, Dubash TD, Ravi A, Wittner BS, Lin M, Morris R, Burr R, Guo H, Seeger K, Szabolcs A, Che D, Nieman L, Getz GA, Ting DT, Lawrence MS, Gainor J, Haber DA, Maheswaran S
published in: Cell reports
information resource reference: TGF-ß in the microenvironment induces a physiologically occurring immune-suppressive senescent state. Cell Rep. 2023 03 28; 42(3):112129.
journal title abbreviation: Cell Rep
publication date: 2023-02-22T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
PubMed Identifier: 36747644
author list: Taylor MS, Connie W, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cheng WC, Heaps J, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Norden BL, Chait BT, Goggins M, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Jung E, Arora KS, Zukerberg LR, Yilmaz OH, Chi G, Matulonis UA, Song Y, Nieman L, Parikh AR, Strickland M, Corcoran RB, Mustelin T, Eng G, Yilmaz ÃH, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH
published in: bioRxiv : the preprint server for biology
information resource reference: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. bioRxiv. 2023 Mar 17.
journal title abbreviation: bioRxiv
publication date: 2023-03-17T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
PubMed Identifier: 36914816
author list: Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
published in: Nature cancer
information resource reference: SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers. Nat Cancer. 2023 03; 4(3):365-381.
journal title abbreviation: Nat Cancer
publication date: 2023-03-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon.
PubMed Identifier: 37258254
author list: Deshpande V, Lee SH, Crabbe A, Pankaj A, Neyaz A, Ono Y, Rickelt S, Sonal S, Ferrone CR, Ting DT, Patil D, Yilmaz O, Berger D, Yilmaz O
published in: Journal of clinical pathology
information resource reference: Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon. J Clin Pathol. 2024 May 17; 77(6):387-393.
journal title abbreviation: J Clin Pathol
publication date: 2024-05-17T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Immune microenvironment and lymph node yield in colorectal cancer.
PubMed Identifier: 37507544
author list: Lee SH, Pankaj A, Neyaz A, Ono Y, Rickelt S, Ferrone C, Ting D, Patil DT, Yilmaz O, Berger D, Deshpande V, Yilmaz O
published in: British journal of cancer
information resource reference: Immune microenvironment and lymph node yield in colorectal cancer. Br J Cancer. 2023 10; 129(6):917-924.
journal title abbreviation: Br J Cancer
publication date: 2023-07-28T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis.
PubMed Identifier: 37425692
author list: Shiau C, Cao J, Gregory MT, Gong D, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Schurman N, Barth JL, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Castillo CF, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL
published in: bioRxiv : the preprint server for biology
information resource reference: Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis. bioRxiv. 2023 Jun 29.
journal title abbreviation: bioRxiv
publication date: 2023-06-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry.
PubMed Identifier: 37292765
author list: Sun S, Hong J, You E, Tsanov KM, Chacon-Barahona J, Gioacchino AD, Hoyos D, Li H, Jiang H, Ly H, Marhon S, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD
published in: bioRxiv : the preprint server for biology
information resource reference: Cancer cells co-evolve with retrotransposons to mitigate viral mimicry. bioRxiv. 2023 May 20.
journal title abbreviation: bioRxiv
publication date: 2023-05-20T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Nieman, Linda
eCommons Login: lin307
first name: Linda
last name: Nieman
full name: Linda Tae Nieman, Ph.D.
has faculty rank: Instructor
Person ID: 216096
person in primary position: Instructor in Medicine
type: Agent
type: Person
preferred title: Instructor in Medicine

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.
PubMed Identifier: 37698949
author list: Taylor MS, Wu C, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cajuso T, Cheng WC, Heaps JD, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Chait BT, Goggins MG, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Fairman JE, Jung E, Arora KS, Yilmaz OH, Cohen S, Sharova T, Chi G, Norden BL, Song Y, Nieman LT, Pappas L, Parikh AR, Strickland MR, Corcoran RB, Mustelin T, Eng G, Yilmaz ÖH, Matulonis UA, Chan AT, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH
published in: Cancer discovery
information resource reference: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker. Cancer Discov. 2023 12 12; 13(12):2532-2547.
journal title abbreviation: Cancer Discov
publication date: 2023-12-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.
PubMed Identifier: 37699201
author list: Patel BK, Raabe MJ, Lang ER, Song Y, Lu C, Deshpande V, Nieman LT, Aryee MJ, Chen YB, Ting DT, DeFilipp Z
published in: Blood
information resource reference: Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD. Blood. 2023 11 23; 142(21):1831-1844.
journal title abbreviation: Blood
publication date: 2023-11-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

The landscape of human SVA retrotransposons.
PubMed Identifier: 37823611
author list: Chu C, Lin EW, Tran A, Jin H, Ho NI, Veit A, Cortes-Ciriano I, Burns KH, Ting DT, Park PJ
published in: Nucleic acids research
information resource reference: The landscape of human SVA retrotransposons. Nucleic Acids Res. 2023 11 27; 51(21):11453-11465.
journal title abbreviation: Nucleic Acids Res
publication date: 2023-11-27T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Proceedings of the inaugural Dark Genome Symposium: November 2022.
PubMed Identifier: 37990347
author list: Boeke JD, Burns KH, Chiappinelli KB, Classon M, Coffin JM, DeCarvalho DD, Dukes JD, Greenbaum B, Kassiotis G, Knutson SK, Levine AJ, Nath A, Papa S, Rios D, Sedivy J, Ting DT
published in: Mobile DNA
information resource reference: Proceedings of the inaugural Dark Genome Symposium: November 2022. Mob DNA. 2023 Nov 21; 14(1):18.
journal title abbreviation: Mob DNA
publication date: 2023-11-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma.
PubMed Identifier: 38105940
author list: Coley AK, Nawrocki C, Patel BK, Pankaj A, Guo Z, Emmett MJ, Lang ER, Song Y, Xu KH, Ferrone CR, Deshpande V, Nieman LT, Aryee MJ, Franses JW, Ting DT
published in: bioRxiv : the preprint server for biology
information resource reference: Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma. bioRxiv. 2025 May 26.
journal title abbreviation: bioRxiv
publication date: 2025-05-26T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.
PubMed Identifier: 38364961
author list: Cattaneo G, Ventin M, Arya S, Kontos F, Michelakos T, Sekigami Y, Cai L, Villani V, Sabbatino F, Chen F, Sadagopan A, Deshpande V, Moore PA, Ting DT, Bardeesy N, Wang X, Ferrone S, Ferrone CR
published in: Cancer letters
information resource reference: Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma. Cancer Lett. 2024 04 10; 587:216713.
journal title abbreviation: Cancer Lett
publication date: 2024-02-14T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
PubMed Identifier: 38393682
author list: Wehrli M, Guinn S, Birocchi F, Kuo A, Sun Y, Larson RC, Almazan AJ, Scarfò I, Bouffard AA, Bailey SR, Anekal PV, Montero Llopis P, Nieman LT, Song Y, Xu KH, Berger TR, Kann MC, Leick MB, Silva H, Salas-Benito D, Kienka T, Grauwet K, Armstrong TD, Zhang R, Zhu Q, Fu J, Schmidts A, Korell F, Jan M, Choi BD, Liss AS, Boland GM, Ting DT, Burkhart RA, Jenkins RW, Zheng L, Jaffee EM, Zimmerman JW, Maus MV
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma. Clin Cancer Res. 2024 May 01; 30(9):1859-1877.
journal title abbreviation: Clin Cancer Res
publication date: 2024-05-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

MIT, Chemical Engineering
end date: 06/1999
educational organization: MIT
training location: Cambridge, MA
type: EducationalTraining
degree earned: SB
major field of degree: Chemical Engineering

MIT, Biology
end date: 06/1999
educational organization: MIT
training location: Cambridge, MA
type: EducationalTraining
degree earned: SB
major field of degree: Biology

Harvard Medical School (HST), Medicine
end date: 06/2004
educational organization: Harvard Medical School (HST)
training location: Boston, MA
type: EducationalTraining
degree earned: MD
major field of degree: Medicine

Massachusetts General Hospital, Internal Medicine
end date: 06/2007
educational organization: Massachusetts General Hospital
training location: Boston, MA
type: EducationalTraining
major field of degree: Internal Medicine

Dana-Farber Harvard Cancer Center, Medical Oncology
end date: 06/2010
educational organization: Dana-Farber Harvard Cancer Center
training location: Boston, MA
type: EducationalTraining
major field of degree: Medical Oncology

Authorship 1635248
type: Authorship
author rank in publication: 48
linked author: Ting, David
linked information resource: Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.

Authorship 1635249
type: Authorship
author rank in publication: 22
linked author: Ting, David
linked information resource: Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.

Authorship 1635250
type: Authorship
author rank in publication: 49
linked author: Ting, David
linked information resource: Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer.

Authorship 1635251
type: Authorship
author rank in publication: 27
linked author: Ting, David
linked information resource: Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype.

Authorship 1635252
type: Authorship
author rank in publication: 50
linked author: Ting, David
linked information resource: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.

Authorship 1635253
type: Authorship
author rank in publication: 32
linked author: Ting, David
linked information resource: Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection.

Authorship 1635254
type: Authorship
author rank in publication: 63
linked author: Ting, David
linked information resource: Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Authorship 1635255
type: Authorship
author rank in publication: 30
linked author: Ting, David
linked information resource: Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial.

Authorship 1635256
type: Authorship
author rank in publication: 33
linked author: Ting, David
linked information resource: Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.

Authorship 1635257
type: Authorship
author rank in publication: 55
linked author: Ting, David
linked information resource: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.

Authorship 1635258
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.

Authorship 1635259
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: Proceedings of the inaugural Dark Genome Symposium: November 2022.

Authorship 1635260
type: Authorship
author rank in publication: 30
linked author: Ting, David
linked information resource: Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma.

Authorship 1638082
type: Authorship
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linked author: Ting, David
linked information resource: Expression of Albumin mRNA in Primary Hepatic Neoplasms and Acinar Cell Carcinoma.

Authorship 1635755
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: In Reply.

Authorship 1636615
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: HIF1A signaling selectively supports proliferation of breast cancer in the brain.

Authorship 1638460
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma.

Authorship 1635684
type: Authorship
author rank in publication: 12
linked author: Ting, David
linked information resource: MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Authorship 1638187
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linked author: Ting, David
linked information resource: Interplay between B7-H3 and HLA class I in the clinical course of pancreatic ductal adenocarcinoma.

Authorship 1635804
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linked author: Ting, David
linked information resource: The histological diagnosis of IgG4-related disease on small biopsies: challenges and pitfalls.

Authorship 1640291
type: Authorship
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linked author: Ting, David
linked information resource: Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.

Authorship 1638469
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author rank in publication: 19
linked author: Ting, David
linked information resource: Expression of ß-globin by cancer cells promotes cell survival during blood-borne dissemination.

Authorship 1635942
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen.

Authorship 1637695
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: Performance of a Branch Chain RNA In Situ Hybridization Assay for the Detection of High-risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma.

Authorship 1635868
type: Authorship
author rank in publication: 4
linked author: Ting, David
linked information resource: X-inactive specific transcript RNA in-situ hybridization as a tool for resolving specimen contamination events.

Authorship 1638100
type: Authorship
author rank in publication: 8
linked author: Ting, David
linked information resource: Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip.

Authorship 1636225
type: Authorship
author rank in publication: 4
linked author: Ting, David
linked information resource: Spontaneous Immune-Mediated Regression of Hepatocellular Carcinoma With High Tumor Mutational Burden.

Authorship 1635711
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: A tumor-specific endogenous repetitive element is induced by herpesviruses.

Authorship 1635862
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon.

Authorship 1635720
type: Authorship
author rank in publication: 13
linked author: Ting, David
linked information resource: PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma.

Authorship 1639054
type: Authorship
author rank in publication: 18
linked author: Ting, David
linked information resource: Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.

Authorship 1635665
type: Authorship
author rank in publication: 12
linked author: Ting, David
linked information resource: Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment.

Authorship 1635668
type: Authorship
author rank in publication: 23
linked author: Ting, David
linked information resource: An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer.

Authorship 1635858
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: Quantitative p53 immunostaining aids in the detection of prevalent dysplasia.

Authorship 1635888
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease.

Authorship 1635705
type: Authorship
author rank in publication: 3
linked author: Ting, David
linked information resource: Molecular Basis of Extramural Vascular Invasion (EMVI) in Colorectal Carcinoma.

Authorship 1635928
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: P53 and the defenses against genome instability caused by transposons and repetitive elements.

Authorship 1635935
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21.

Authorship 1635846
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: TGF-ß in the microenvironment induces a physiologically occurring immune-suppressive senescent state.

Authorship 1637822
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer.

Authorship 1640248
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer.

Authorship 1638184
type: Authorship
author rank in publication: 1
linked author: Ting, David
linked information resource: The wide gulf between stage III and stage IV colon cancer.

Authorship 1637561
type: Authorship
author rank in publication: 18
linked author: Ting, David
linked information resource: Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.

Authorship 1639084
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation.

Authorship 1636749
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody.

Authorship 1635910
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma.

Authorship 1640195
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response.

Authorship 1637819
type: Authorship
author rank in publication: 8
linked author: Ting, David
linked information resource: Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.

Authorship 1635647
type: Authorship
author rank in publication: 18
linked author: Ting, David
linked information resource: Supportive Oncology Care at Home Intervention for Patients With Pancreatic Cancer.

Authorship 1638557
type: Authorship
author rank in publication: 8
linked author: Ting, David
linked information resource: BRCA1 haploinsufficiency for replication stress suppression in primary cells.

Authorship 1638610
type: Authorship
author rank in publication: 1
linked author: Ting, David
linked information resource: Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT.

Authorship 1638230
type: Authorship
author rank in publication: 17
linked author: Ting, David
linked information resource: COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis.

Authorship 1636484
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Authorship 1635951
type: Authorship
author rank in publication: 3
linked author: Ting, David
linked information resource: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.

Authorship 1638238
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.

Authorship 1640206
type: Authorship
author rank in publication: 6
linked author: Ting, David
linked information resource: Microsatellite instability in gallbladder carcinoma.

Authorship 1638528
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

Authorship 1639100
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: Conditional Survival in Resected Pancreatic Ductal Adenocarcinoma Patients Treated with Total Neoadjuvant Therapy.

Authorship 1640182
type: Authorship
author rank in publication: 18
linked author: Ting, David
linked information resource: ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer.

Authorship 1640191
type: Authorship
author rank in publication: 11
linked author: Ting, David
linked information resource: Quasimesenchymal phenotype predicts systemic metastasis in pancreatic ductal adenocarcinoma.

Authorship 1638093
type: Authorship
author rank in publication: 11
linked author: Ting, David
linked information resource: Comparison of RNA In Situ Hybridization and Immunohistochemistry Techniques for the Detection and Localization of SARS-CoV-2 in Human Tissues.

Authorship 1640238
type: Authorship
author rank in publication: 6
linked author: Ting, David
linked information resource: Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma.

Authorship 1640181
type: Authorship
author rank in publication: 36
linked author: Ting, David
linked information resource: TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.

Authorship 1635788
type: Authorship
author rank in publication: 6
linked author: Ting, David
linked information resource: Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs).

Authorship 1638201
type: Authorship
author rank in publication: 3
linked author: Ting, David
linked information resource: The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia.

Authorship 1640284
type: Authorship
author rank in publication: 5
linked author: Ting, David
linked information resource: Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer.

Authorship 1639116
type: Authorship
author rank in publication: 5
linked author: Ting, David
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/184207909

Authorship 1635689
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: Selective targeting of MYC mRNA by stabilized antisense oligonucleotides.

Authorship 1638484
type: Authorship
author rank in publication: 4
linked author: Ting, David
linked information resource: GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma.

Authorship 1640266
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.

Authorship 1638229
type: Authorship
author rank in publication: 14
linked author: Ting, David
linked information resource: LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia.

Authorship 1639058
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer.

Authorship 1638217
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.

Authorship 1637000
type: Authorship
author rank in publication: 5
linked author: Ting, David
linked information resource: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers.

Authorship 1639122
type: Authorship
author rank in publication: 3
linked author: Ting, David
linked information resource: Immunological and Clinico-Molecular Features of Tumor Border Configuration in Colorectal Cancer.

Authorship 1635753
type: Authorship
author rank in publication: 37
linked author: Ting, David
linked information resource: Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Authorship 1635896
type: Authorship
author rank in publication: 22
linked author: Ting, David
linked information resource: An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma.

Authorship 1636877
type: Authorship
author rank in publication: 13
linked author: Ting, David
linked information resource: High IDO1 Expression Is Associated with Poor Outcome in Patients with Anal Cancer Treated with Definitive Chemoradiotherapy.

Authorship 1639065
type: Authorship
author rank in publication: 6
linked author: Ting, David
linked information resource: Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

Authorship 1639650
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.

Authorship 1640279
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.

Authorship 1639113
type: Authorship
author rank in publication: 24
linked author: Ting, David
linked information resource: The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.

Authorship 1635783
type: Authorship
author rank in publication: 30
linked author: Ting, David
linked information resource: Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection.

Authorship 1640257
type: Authorship
author rank in publication: 3
linked author: Ting, David
linked information resource: Reply.

Authorship 1636486
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.

Authorship 1638074
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis.

Authorship 1635809
type: Authorship
author rank in publication: 11
linked author: Ting, David
linked information resource: MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.

Authorship 1639102
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.

Authorship 1638602
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: Branched Chain RNA In Situ Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer.

Authorship 1639091
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes.

Authorship 1638482
type: Authorship
author rank in publication: 18
linked author: Ting, David
linked information resource: Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer.

Authorship 1638468
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: Chimeric antigen receptor costimulation domains modulate human regulatory T cell function.

Authorship 1638450
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells.

Authorship 1638612
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.

Authorship 1639126
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: Amplification-free digital gene expression profiling from minute cell quantities.

Authorship 1635774
type: Authorship
author rank in publication: 19
linked author: Ting, David
linked information resource: Cancer cells co-evolve with retrotransposons to mitigate viral mimicry.

Authorship 1639142
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Programmed death-ligand 1 expression in the immune compartment of colon carcinoma.

Authorship 1635943
type: Authorship
author rank in publication: 21
linked author: Ting, David
linked information resource: Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.

Authorship 1639780
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Authorship 1639398
type: Authorship
author rank in publication: 4
linked author: Ting, David
linked information resource: Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.

Authorship 1639130
type: Authorship
author rank in publication: 17
linked author: Ting, David
linked information resource: Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.

Authorship 1635652
type: Authorship
author rank in publication: 31
linked author: Ting, David
linked information resource: SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.

Authorship 1635747
type: Authorship
author rank in publication: 1
linked author: Ting, David
linked information resource: Venture capital in academia: does present reality call for more nonprofit venture?

Authorship 1636875
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linked author: Ting, David
linked information resource: LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy.

Authorship 1638113
type: Authorship
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linked author: Ting, David
linked information resource: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.

Authorship 1635866
type: Authorship
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linked author: Ting, David
linked information resource: The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

Authorship 1639081
type: Authorship
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linked author: Ting, David
linked information resource: Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms.

Authorship 1635796
type: Authorship
author rank in publication: 20
linked author: Ting, David
linked information resource: Differential Kinase Activity Across Prostate Tumor Compartments Defines Sensitivity to Target Inhibition.

Authorship 1638106
type: Authorship
author rank in publication: 13
linked author: Ting, David
linked information resource: Pancreatic ductal adenocarcinoma: tumour regression grading following neoadjuvant FOLFIRINOX and radiation.

Authorship 1635717
type: Authorship
author rank in publication: 19
linked author: Ting, David
linked information resource: HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Authorship 1640166
type: Authorship
author rank in publication: 2
linked author: Ting, David
linked information resource: Somatic Mutations in Liver Disease: Adaptation Without Carcinogenesis?

Authorship 1638147
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

Authorship 1638197
type: Authorship
author rank in publication: 16
linked author: Ting, David
linked information resource: Transcriptomic Analysis of Laser Capture Microdissected Tumors Reveals Cancer- and Stromal-Specific Molecular Subtypes of Pancreatic Ductal Adenocarcinoma.

Authorship 1638480
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Correlation of clinical, pathologic, and genetic parameters with intratumoral immune milieu in mucinous adenocarcinoma of the colon.

Authorship 1637297
type: Authorship
author rank in publication: 12
linked author: Ting, David
linked information resource: Tumor Microenvironment Immune Response in Pancreatic Ductal Adenocarcinoma Patients Treated With Neoadjuvant Therapy.

Authorship 1638508
type: Authorship
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linked author: Ting, David
linked information resource: No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.

Authorship 1635815
type: Authorship
author rank in publication: 10
linked author: Ting, David
linked information resource: FGFR mRNA Expression in Cholangiocarcinoma and Its Correlation with FGFR2 Fusion Status and Immune Signatures.

Authorship 1638593
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.

Authorship 1637431
type: Authorship
author rank in publication: 26
linked author: Ting, David
linked information resource: Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis.

Authorship 1638076
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: Immune microenvironment and lymph node yield in colorectal cancer.

Authorship 1638094
type: Authorship
author rank in publication: 37
linked author: Ting, David
linked information resource: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Authorship 1639066
type: Authorship
author rank in publication: 14
linked author: Ting, David
linked information resource: Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.

Authorship 1639133
type: Authorship
author rank in publication: 6
linked author: Ting, David
linked information resource: Branched-chain in situ hybridization for ? and ? light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples.

Authorship 1635751
type: Authorship
author rank in publication: 5
linked author: Ting, David
linked information resource: Phosphorylated Histone H3 (PHH3) Is a Superior Proliferation Marker for Prognosis of Pancreatic Neuroendocrine Tumors.

Authorship 1638521
type: Authorship
author rank in publication: 8
linked author: Ting, David
linked information resource: Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.

Authorship 1638150
type: Authorship
author rank in publication: 9
linked author: Ting, David
linked information resource: The landscape of human SVA retrotransposons.

Authorship 1640205
type: Authorship
author rank in publication: 7
linked author: Ting, David
linked information resource: A Code of Mono-phosphorylation Modulates the Function of RB.

Authorship 1640282
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Isolation and molecular characterization of circulating melanoma cells.

Authorship 1638205
type: Authorship
author rank in publication: 12
linked author: Ting, David
linked information resource: Glioblastoma hijacks microglial gene expression to support tumor growth.

Authorship 1638547
type: Authorship
author rank in publication: 5
linked author: Ting, David
linked information resource: Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies.

Authorship 1637029
type: Authorship
author rank in publication: 1
linked author: Ting, David
linked information resource: Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.

Authorship 1635937
type: Authorship
author rank in publication: 17
linked author: Ting, David
linked information resource: Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.

Authorship 1635686
type: Authorship
author rank in publication: 8
linked author: Ting, David
linked information resource: Giant Cell Lesions of the Maxillofacial Skeleton Express RANKL by RNA In Situ Hybridization Regardless of Histologic Pattern.

P53 and the defenses against genome instability caused by transposons and repetitive elements.
PubMed Identifier: 27172878
author list: Levine AJ, Ting DT, Greenbaum BD
published in: BioEssays : news and reviews in molecular, cellular and developmental biology
information resource reference: P53 and the defenses against genome instability caused by transposons and repetitive elements. Bioessays. 2016 06; 38(6):508-13.
journal title abbreviation: Bioessays
publication date: 2016-05-13T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.
PubMed Identifier: 26575629
author list: Tanne A, Muniz LR, Puzio-Kuter A, Leonova KI, Gudkov AV, Ting DT, Monasson R, Cocco S, Levine AJ, Bhardwaj N, Greenbaum BD
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15154-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-11-02T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation.
PubMed Identifier: 28469092
author list: Badal B, Solovyov A, Di Cecilia S, Chan JM, Chang LW, Iqbal R, Aydin IT, Rajan GS, Chen C, Abbate F, Arora KS, Tanne A, Gruber SB, Johnson TM, Fullen DR, Raskin L, Phelps R, Bhardwaj N, Bernstein E, Ting DT, Brunner G, Schadt EE, Greenbaum BD, Celebi JT
published in: JCI insight
information resource reference: Transcriptional dissection of melanoma identifies a high-risk subtype underlying TP53 family genes and epigenome deregulation. JCI Insight. 2017 May 04; 2(9).
journal title abbreviation: JCI Insight
publication date: 2017-05-04T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes.
PubMed Identifier: 29642008
author list: Solovyov A, Vabret N, Arora KS, Snyder A, Funt SA, Bajorin DF, Rosenberg JE, Bhardwaj N, Ting DT, Greenbaum BD
published in: Cell reports
information resource reference: Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes. Cell Rep. 2018 Apr 10; 23(2):512-521.
journal title abbreviation: Cell Rep
publication date: 2018-04-10T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Venture capital in academia: does present reality call for more nonprofit venture?
PubMed Identifier: 32484456
author list: Ting DT, Knowles JJ
published in: The Journal of clinical investigation
information resource reference: Venture capital in academia: does present reality call for more nonprofit venture? J Clin Invest. 2020 07 01; 130(7):3336-3338.
journal title abbreviation: J Clin Invest
publication date: 2020-07-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1642240
type: Authorship
author rank in publication: 23
linked author: Ting, David
linked information resource: Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.

Authorship 1641598
type: Authorship
author rank in publication: 28
linked author: Ting, David
linked information resource: Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.
PubMed Identifier: 38559183
author list: Mishra A, Huang SB, Dubash T, Burr R, Edd JF, Wittner BS, Cunneely QE, Putaturo VR, Deshpande A, Antmen E, Gopinathan KA, Otani K, Miyazawa Y, Kwak JE, Guay SY, Kelly J, Walsh J, Nieman L, Galler I, Chan P, Lawrence MS, Sullivan RJ, Bardia A, Micalizzi DS, Sequist LV, Lee RJ, Franses JW, Ting DT, Brunker PAR, Maheswaran S, Miyamoto DT, Haber DA, Toner M
published in: bioRxiv : the preprint server for biology
information resource reference: Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product. bioRxiv. 2024 Mar 14.
journal title abbreviation: bioRxiv
publication date: 2024-03-14T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.
PubMed Identifier: 38587552
author list: Guinn S, Kinny-Köster B, Tandurella JA, Mitchell JT, Sidiropoulos DN, Loth M, Lyman MR, Pucsek AB, Zabransky DJ, Lee JW, Kartalia E, Ramani M, Seppälä TT, Cherry C, Suri R, Zlomke H, Patel J, He J, Wolfgang CL, Yu J, Zheng L, Ryan DP, Ting DT, Kimmelman A, Gupta A, Danilova L, Elisseeff JH, Wood LD, Stein-O'Brien G, Kagohara LT, Jaffee EM, Burkhart RA, Fertig EJ, Zimmerman JW
published in: Cancer research
information resource reference: Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2024 May 02; 84(9):1517-1533.
journal title abbreviation: Cancer Res
publication date: 2024-05-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1659857
type: Authorship
author rank in publication: 4
linked author: Ting, David
linked information resource: ß2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma.

ß2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma.
PubMed Identifier: 38869306
author list: Lee SH, Pankaj A, Rickelt S, Ting D, Ferrone C, Patil DT, Yilmaz O, Berger D, Deshpande V, Yilmaz O
published in: American journal of clinical pathology
information resource reference: ß2-microglobulin expression is associated with aggressive histology, activated tumor immune milieu, and outcome in colon carcinoma. Am J Clin Pathol. 2024 11 04; 162(5):500-508.
journal title abbreviation: Am J Clin Pathol
publication date: 2024-11-04T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: MGH Cancer Center Research
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Massachusetts General Hospital

Authorship 1688747
type: Authorship
author rank in publication: 30
linked author: Ting, David
linked information resource: Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment.

Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment.
PubMed Identifier: 39227743
author list: Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Bae JW, Zhao R, Schurman N, Barth JL, Ganci ML, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Castillo CF, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL
published in: Nature genetics
information resource reference: Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment. Nat Genet. 2024 Nov; 56(11):2466-2478.
journal title abbreviation: Nat Genet
publication date: 2024-09-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies.
PubMed Identifier: 39346545
author list: Esfahani SA, Ma H, Krishna S, Shuvaev S, Sabbagh M, Deffler C, Rotile N, Weigand-Whittier J, Zhou IY, Catana C, Catalano OA, Ting DT, Heidari P, Abston E, Lanuti M, Boland GM, Pathak P, Roberts H, Tanabe KK, Qadan M, Castillo CF, Shih A, Parikh AR, Weekes CD, Hong TS, Caravan P
published in: Theranostics
information resource reference: Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies. Theranostics. 2024; 14(15):5745-5761.
journal title abbreviation: Theranostics
publication date: 2024-09-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab.
PubMed Identifier: 39417106
author list: Park RJ, Parikh M, Pappas L, Sade-Feldman M, Kulkarni AS, Bi L, LaSalle TJ, Galway A, Kuhlman C, Blaszkowsky LS, Meyerhardt JA, Enzinger PC, Biller L, Allen JN, Kagey MH, Baum J, Sirard C, Duda DG, Zhu AX, Abrams TA, Hacohen N, Ting DT, Mehta A, Goyal L
published in: medRxiv : the preprint server for health sciences
information resource reference: Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab. medRxiv. 2024 Oct 08.
journal title abbreviation: medRxiv
publication date: 2024-10-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1702560
type: Authorship
author rank in publication: 14
linked author: Ting, David
linked information resource: HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions.

Authorship 1695579
type: Authorship
author rank in publication: 29
linked author: Ting, David
linked information resource: Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer.

Authorship 1700265
type: Authorship
author rank in publication: 12
linked author: Ting, David
linked information resource: Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies.

HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions.
PubMed Identifier: 39330965
author list: Lu C, Pankaj A, Raabe M, Nawrocki C, Liu A, Xu N, Patel BK, Emmett MJ, Coley AK, Ferrone CR, Deshpande V, Bhan I, Hoshida Y, Ting DT, Aryee MJ, Franses JW
published in: Hepatology communications
information resource reference: HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions. Hepatol Commun. 2024 10 01; 8(10).
journal title abbreviation: Hepatol Commun
publication date: 2024-09-27T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer.
PubMed Identifier: 39383862
author list: You E, Danaher P, Lu C, Sun S, Zou L, Phillips IE, Rojas AS, Ho NI, Song Y, Raabe MJ, Xu KH, Richieri PM, Li H, Aston N, Porter RL, Patel BK, Nieman LT, Schurman N, Hudson BM, North K, Church SE, Deshpande V, Liss AS, Kim TK, Cui Y, Kim Y, Greenbaum BD, Aryee MJ, Ting DT
published in: Cell
information resource reference: Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer. Cell. 2024 Dec 12; 187(25):7232-7247.e23.
journal title abbreviation: Cell
publication date: 2024-10-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1703430
type: Authorship
author rank in publication: 15
linked author: Ting, David
linked information resource: Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.

Authorship 1703478
type: Authorship
author rank in publication: 22
linked author: Ting, David
linked information resource: Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab.

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.
PubMed Identifier: 39485038
author list: Dimitrieva S, Harrison JM, Chang J, Piquet M, Mino-Kenudson M, Gabriel M, Sagar V, Horn H, Lage K, Kim J, Li G, Weng S, Harris C, Kulkarni AS, Ting DT, Qadan M, Fagenholz PJ, Ferrone CR, Grauel AL, Laszewski T, Raza A, Riester M, Somerville T, Wagner JP, Dranoff G, Engelman JA, Kauffmann A, Leary R, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C, Ruddy DA, Liss AS, Cremasco V
published in: Cancer research communications
information resource reference: Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer. Cancer Res Commun. 2024 12 01; 4(12):3049-3066.
journal title abbreviation: Cancer Res Commun
publication date: 2024-12-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Surgery
position in organization: Massachusetts General Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.
PubMed Identifier: 24360956
author list: Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA
published in: Cell reports
information resource reference: Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1. Cell Rep. 2013 Dec 26; 5(6):1679-89.
journal title abbreviation: Cell Rep
publication date: 2013-12-19T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

W. Gerald Austen Professor of Surgery, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: W. Gerald Austen Professor of Surgery, Emeritus
position in organization: Harvard Medical School

Professor of Radiation Oncology
is primary position: true
position in department: Radiation Oncology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Radiation Oncology
position in organization: Beth Israel Deaconess Medical Center

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology
position in organization: Beth Israel Deaconess Medical Center

Isolation and molecular characterization of circulating melanoma cells.
PubMed Identifier: 24746818
author list: Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, Ramaswamy S, Toner M, Fisher DE, Maheswaran S, Haber DA
published in: Cell reports
information resource reference: Isolation and molecular characterization of circulating melanoma cells. Cell Rep. 2014 May 08; 7(3):645-53.
journal title abbreviation: Cell Rep
publication date: 2014-04-18T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Bhan, Irun
eCommons Login: IB15
first name: Irun
last name: Bhan
full name: Irun Bhan, M.D.
has faculty rank: Instructor
Person ID: 50172
person in primary position: Instructor in Medicine
type: Agent
type: Person
preferred title: Instructor in Medicine

The wide gulf between stage III and stage IV colon cancer.
PubMed Identifier: 24928084
author list: Ting DT, Ryan DP
published in: The Lancet. Oncology
information resource reference: The wide gulf between stage III and stage IV colon cancer. Lancet Oncol. 2014 Jul; 15(8):785-6.
journal title abbreviation: Lancet Oncol
publication date: 2014-06-11T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.
PubMed Identifier: 25013076
author list: Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA
published in: Science (New York, N.Y.)
information resource reference: Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20.
journal title abbreviation: Science
publication date: 2014-07-11T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.
PubMed Identifier: 25171411
author list: Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S
published in: Cell
information resource reference: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell. 2014 Aug 28; 158(5):1110-1122.
journal title abbreviation: Cell
publication date: 2014-08-28T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.
PubMed Identifier: 25242334
author list: Ting DT, Wittner BS, Ligorio M, Vincent Jordan N, Shah AM, Miyamoto DT, Aceto N, Bersani F, Brannigan BW, Xega K, Ciciliano JC, Zhu H, MacKenzie OC, Trautwein J, Arora KS, Shahid M, Ellis HL, Qu N, Bardeesy N, Rivera MN, Deshpande V, Ferrone CR, Kapur R, Ramaswamy S, Shioda T, Toner M, Maheswaran S, Haber DA
published in: Cell reports
information resource reference: Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 2014 Sep 25; 8(6):1905-1918.
journal title abbreviation: Cell Rep
publication date: 2014-09-18T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

BRCA1 haploinsufficiency for replication stress suppression in primary cells.
PubMed Identifier: 25400221
author list: Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM
published in: Nature communications
information resource reference: BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014 Nov 17; 5:5496.
journal title abbreviation: Nat Commun
publication date: 2014-11-17T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.
PubMed Identifier: 25453903
author list: Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN
published in: Cancer cell
information resource reference: EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014 Nov 10; 26(5):668-681.
journal title abbreviation: Cancer Cell
publication date: 2014-10-30T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms.
PubMed Identifier: 25353287
author list: Shahid M, Mubeen A, Tse J, Kakar S, Bateman AC, Borger D, Rivera MN, Ting DT, Deshpande V
published in: The American journal of surgical pathology
information resource reference: Branched chain in situ hybridization for albumin as a marker of hepatocellular differentiation: evaluation of manual and automated in situ hybridization platforms. Am J Surg Pathol. 2015 Jan; 39(1):25-34.
journal title abbreviation: Am J Surg Pathol
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.
PubMed Identifier: 25984697
author list: Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M
published in: Nature methods
information resource reference: A microfluidic device for label-free, physical capture of circulating tumor cell clusters. Nat Methods. 2015 Jul; 12(7):685-91.
journal title abbreviation: Nat Methods
publication date: 2015-05-18T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.
PubMed Identifier: 25678598
author list: Javaid S, Zhang J, Smolen GA, Yu M, Wittner BS, Singh A, Arora KS, Madden MW, Desai R, Zubrowski MJ, Schott BJ, Ting DT, Stott SL, Toner M, Maheswaran S, Shioda T, Ramaswamy S, Haber DA
published in: Molecular cancer research : MCR
information resource reference: MAPK7 Regulates EMT Features and Modulates the Generation of CTCs. Mol Cancer Res. 2015 May; 13(5):934-43.
journal title abbreviation: Mol Cancer Res
publication date: 2015-02-12T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Microsatellite instability in gallbladder carcinoma.
PubMed Identifier: 25680569
author list: Moy AP, Shahid M, Ferrone CR, Borger DR, Zhu AX, Ting D, Deshpande V
published in: Virchows Archiv : an international journal of pathology
information resource reference: Microsatellite instability in gallbladder carcinoma. Virchows Arch. 2015 Apr; 466(4):393-402.
journal title abbreviation: Virchows Arch
publication date: 2015-02-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.
PubMed Identifier: 25882849
author list: Kim WJ, Wittner BS, Amzallag A, Brannigan BW, Ting DT, Ramaswamy S, Maheswaran S, Haber DA
published in: The Journal of biological chemistry
information resource reference: The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28. J Biol Chem. 2015 Jun 05; 290(23):14381-90.
journal title abbreviation: J Biol Chem
publication date: 2015-04-16T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer.
PubMed Identifier: 25599322
author list: Ferrone CR, Marchegiani G, Hong TS, Ryan DP, Deshpande V, McDonnell EI, Sabbatino F, Santos DD, Allen JN, Blaszkowsky LS, Clark JW, Faris JE, Goyal L, Kwak EL, Murphy JE, Ting DT, Wo JY, Zhu AX, Warshaw AL, Lillemoe KD, Fernández-del Castillo C
published in: Annals of surgery
information resource reference: Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer. Ann Surg. 2015 Jan; 261(1):12-7.
journal title abbreviation: Ann Surg
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of Albumin mRNA in Primary Hepatic Neoplasms and Acinar Cell Carcinoma.
PubMed Identifier: 26171921
author list: Ting DT, Deshpande V
published in: The American journal of surgical pathology
information resource reference: Expression of Albumin mRNA in Primary Hepatic Neoplasms and Acinar Cell Carcinoma. Am J Surg Pathol. 2015 Aug; 39(8):1157-8.
journal title abbreviation: Am J Surg Pathol
publication date: 2015-08-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.
PubMed Identifier: 26383955
author list: Miyamoto DT, Zheng Y, Wittner BS, Lee RJ, Zhu H, Broderick KT, Desai R, Fox DB, Brannigan BW, Trautwein J, Arora KS, Desai N, Dahl DM, Sequist LV, Smith MR, Kapur R, Wu CL, Shioda T, Ramaswamy S, Ting DT, Toner M, Maheswaran S, Haber DA
published in: Science (New York, N.Y.)
information resource reference: RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science. 2015 Sep 18; 349(6254):1351-6.
journal title abbreviation: Science
publication date: 2015-09-18T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Branched-chain in situ hybridization for ? and ? light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples.
PubMed Identifier: 26524200
author list: Arora K, Chebib I, Zukerberg L, Gandhi M, Rivera M, Ting D, Deshpande V
published in: Cancer cytopathology
information resource reference: Branched-chain in situ hybridization for ? and ? light chains: A powerful ancillary technique for determining B-cell clonality in cytology samples. Cancer Cytopathol. 2016 Mar; 124(3):203-12.
journal title abbreviation: Cancer Cytopathol
publication date: 2015-11-02T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Performance of a Branch Chain RNA In Situ Hybridization Assay for the Detection of High-risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma.
PubMed Identifier: 26426378
author list: Kerr DA, Arora KS, Mahadevan KK, Hornick JL, Krane JF, Rivera MN, Ting DT, Deshpande V, Faquin WC
published in: The American journal of surgical pathology
information resource reference: Performance of a Branch Chain RNA In Situ Hybridization Assay for the Detection of High-risk Human Papillomavirus in Head and Neck Squamous Cell Carcinoma. Am J Surg Pathol. 2015 Dec; 39(12):1643-52.
journal title abbreviation: Am J Surg Pathol
publication date: 2015-12-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.
PubMed Identifier: 26575630
author list: Bersani F, Lee E, Kharchenko PV, Xu AW, Liu M, Xega K, MacKenzie OC, Brannigan BW, Wittner BS, Jung H, Ramaswamy S, Park PJ, Maheswaran S, Ting DT, Haber DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15148-53.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-11-02T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.
PubMed Identifier: 25786746
author list: Ferrone CR, Ting DT, Shahid M, Konstantinidis IT, Sabbatino F, Goyal L, Rice-Stitt T, Mubeen A, Arora K, Bardeesy N, Miura J, Gamblin TC, Zhu AX, Borger D, Lillemoe KD, Rivera MN, Deshpande V
published in: Annals of surgical oncology
information resource reference: Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1609.
journal title abbreviation: Ann Surg Oncol
publication date: 2015-12-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.
PubMed Identifier: 25575648
author list: Ferrone CR, Ting DT, Shahid M, Konstantinidis IT, Sabbatino F, Goyal L, Rice-Stitt T, Mubeen A, Arora K, Bardeesey N, Miura J, Gamblin TC, Zhu AX, Borger D, Lillemoe KD, Rivera MN, Deshpande V
published in: Annals of surgical oncology
information resource reference: Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1604.
journal title abbreviation: Ann Surg Oncol
publication date: 2015-12-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.
PubMed Identifier: 25519926
author list: Ferrone CR, Ting DT, Shahid M, Konstantinidis IT, Sabbatino F, Goyal L, Rice-Stitt T, Mubeen A, Arora K, Bardeesey N, Miura J, Gamblin TC, Zhu AX, Borger D, Lillemoe KD, Rivera MN, Deshpande V
published in: Annals of surgical oncology
information resource reference: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology. Ann Surg Oncol. 2016 Jan; 23(1):290-6.
journal title abbreviation: Ann Surg Oncol
publication date: 2014-12-18T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma.
PubMed Identifier: 26373575
author list: Sabbatino F, Villani V, Yearley JH, Deshpande V, Cai L, Konstantinidis IT, Moon C, Nota S, Wang Y, Al-Sukaini A, Zhu AX, Goyal L, Ting DT, Bardeesy N, Hong TS, Fernandez-del Castillo C, Tanabe KK, Lillemoe KD, Ferrone S, Ferrone CR
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2016 Jan 15; 22(2):470-8.
journal title abbreviation: Clin Cancer Res
publication date: 2015-09-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.
PubMed Identifier: 27082874
author list: Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER
published in: Biomaterials
information resource reference: A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma. Biomaterials. 2016 07; 93:71-82.
journal title abbreviation: Biomaterials
publication date: 2016-03-31T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma.
PubMed Identifier: 26956004
author list: Deshpande V, Konstantinidis IT, Castillo CF, Hezel AF, Haigis KM, Ting DT, Bardeesy N, Goyal L, Zhu AX, Warshaw AL, Lillemoe KD, Ferrone CR
published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
information resource reference: Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma. J Gastrointest Surg. 2016 05; 20(5):953-9.
journal title abbreviation: J Gastrointest Surg
publication date: 2016-03-08T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Branched Chain RNA In Situ Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer.
PubMed Identifier: 27440270
author list: Saylor PJ, Lee RJ, Arora KS, Deshpande V, Hu R, Olivier K, Meneely E, Rivera MN, Ting DT, Wu CL, Miyamoto DT
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Branched Chain RNA In Situ Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer. Clin Cancer Res. 2017 Jan 15; 23(2):363-369.
journal title abbreviation: Clin Cancer Res
publication date: 2016-07-20T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

55 Fruit St
type: Address
address line 1: Massachusetts General Hospital
address line 3: 55 Fruit St
city: Boston
postal code: 02114
state or province: MA

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.
PubMed Identifier: 27926867
author list: Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran S
published in: Cell reports
information resource reference: Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 12 06; 17(10):2632-2647.
journal title abbreviation: Cell Rep
publication date: 2016-12-06T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

HER2 expression identifies dynamic functional states within circulating breast cancer cells.
PubMed Identifier: 27556950
author list: Jordan NV, Bardia A, Wittner BS, Benes C, Ligorio M, Zheng Y, Yu M, Sundaresan TK, Licausi JA, Desai R, O'Keefe RM, Ebright RY, Boukhali M, Sil S, Onozato ML, Iafrate AJ, Kapur R, Sgroi D, Ting DT, Toner M, Ramaswamy S, Haas W, Maheswaran S, Haber DA
published in: Nature
information resource reference: HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature. 2016 09 01; 537(7618):102-106.
journal title abbreviation: Nature
publication date: 2016-08-24T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylated Histone H3 (PHH3) Is a Superior Proliferation Marker for Prognosis of Pancreatic Neuroendocrine Tumors.
PubMed Identifier: 27020585
author list: Villani V, Mahadevan KK, Ligorio M, Fernández-Del Castillo C, Ting DT, Sabbatino F, Zhang I, Vangel M, Ferrone S, Warshaw AL, Lillemoe KD, Wargo J, Deshpande V, Ferrone CR
published in: Annals of surgical oncology
information resource reference: Phosphorylated Histone H3 (PHH3) Is a Superior Proliferation Marker for Prognosis of Pancreatic Neuroendocrine Tumors. Ann Surg Oncol. 2016 12; 23(Suppl 5):609-617.
journal title abbreviation: Ann Surg Oncol
publication date: 2016-03-28T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Qadan, Motaz
eCommons Login: MQ28
first name: Motaz
last name: Qadan
full name: Motaz Qadan, M.D., Ph.D.
has faculty rank: Associate Professor
Person ID: 155249
person in primary position: Associate Professor of Surgery
type: Agent
type: Person
preferred title: Associate Professor of Surgery

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma.
PubMed Identifier: 28096363
author list: Kalinich M, Bhan I, Kwan TT, Miyamoto DT, Javaid S, LiCausi JA, Milner JD, Hong X, Goyal L, Sil S, Choz M, Ho U, Kapur R, Muzikansky A, Zhang H, Weitz DA, Sequist LV, Ryan DP, Chung RT, Zhu AX, Isselbacher KJ, Ting DT, Toner M, Maheswaran S, Haber DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1123-1128.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2017-01-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip.
PubMed Identifier: 28133963
author list: Park MH, Reátegui E, Li W, Tessier SN, Wong KH, Jensen AE, Thapar V, Ting D, Toner M, Stott SL, Hammond PT
published in: Journal of the American Chemical Society
information resource reference: Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip. J Am Chem Soc. 2017 02 22; 139(7):2741-2749.
journal title abbreviation: J Am Chem Soc
publication date: 2017-02-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of ß-globin by cancer cells promotes cell survival during blood-borne dissemination.
PubMed Identifier: 28181495
author list: Zheng Y, Miyamoto DT, Wittner BS, Sullivan JP, Aceto N, Jordan NV, Yu M, Karabacak NM, Comaills V, Morris R, Desai R, Desai N, Emmons E, Milner JD, Lee RJ, Wu CL, Sequist LV, Haas W, Ting DT, Toner M, Ramaswamy S, Maheswaran S, Haber DA
published in: Nature communications
information resource reference: Expression of ß-globin by cancer cells promotes cell survival during blood-borne dissemination. Nat Commun. 2017 02 09; 8:14344.
journal title abbreviation: Nat Commun
publication date: 2017-02-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer.
PubMed Identifier: 28194445
author list: Desai N, Sajed D, Arora KS, Solovyov A, Rajurkar M, Bledsoe JR, Sil S, Amri R, Tai E, MacKenzie OC, Mino-Kenudson M, Aryee MJ, Ferrone CR, Berger DL, Rivera MN, Greenbaum BD, Deshpande V, Ting DT
published in: JCI insight
information resource reference: Diverse repetitive element RNA expression defines epigenetic and immunologic features of colon cancer. JCI Insight. 2017 02 09; 2(3):e91078.
journal title abbreviation: JCI Insight
publication date: 2017-02-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.
PubMed Identifier: 28389596
author list: Miyamoto DT, Ting DT, Toner M, Maheswaran S, Haber DA
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity. Cold Spring Harb Symp Quant Biol. 2016; 81:269-274.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 2017-04-07T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
PubMed Identifier: 23372014
author list: Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S
published in: Science (New York, N.Y.)
information resource reference: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013 Feb 01; 339(6119):580-4.
journal title abbreviation: Science
publication date: 2013-02-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen.
PubMed Identifier: 17468773
author list: Dey BR, Shaffer J, Yee AJ, McAfee S, Caron M, Power K, Ting DT, Colby C, Preffer F, Ballen K, Attar E, Saidman S, Tarbell N, Sachs D, Sykes M, Spitzer TR
published in: Bone marrow transplantation
information resource reference: Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen. Bone Marrow Transplant. 2007 Jul; 40(1):19-27.
journal title abbreviation: Bone Marrow Transplant
publication date: 2007-04-30T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT.
PubMed Identifier: 18587439
author list: Ting DT, Spitzer TR, Chaudhary A, Muzikansky A, Colby C, Power K, McAfee S, Ballen K, Attar E, Saidman SL, Preffer F, Sykes M, Dey BR
published in: Bone marrow transplantation
information resource reference: Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT. Bone Marrow Transplant. 2008 Sep; 42(5):329-35.
journal title abbreviation: Bone Marrow Transplant
publication date: 2008-06-30T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

X-inactive specific transcript RNA in-situ hybridization as a tool for resolving specimen contamination events.
PubMed Identifier: 28556238
author list: Crotty R, Arora K, Prasad S, Ting DT, Rivera MN, Deshpande V
published in: Histopathology
information resource reference: X-inactive specific transcript RNA in-situ hybridization as a tool for resolving specimen contamination events. Histopathology. 2017 10; 71(4):662-665.
journal title abbreviation: Histopathology
publication date: 2017-07-19T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.
PubMed Identifier: 23552373
author list: Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, Yu M, Chen PI, Morgan B, Trautwein J, Kimura A, Sengupta S, Stott SL, Karabacak NM, Barber TA, Walsh JR, Smith K, Spuhler PS, Sullivan JP, Lee RJ, Ting DT, Luo X, Shaw AT, Bardia A, Sequist LV, Louis DN, Maheswaran S, Kapur R, Haber DA, Toner M
published in: Science translational medicine
information resource reference: Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med. 2013 Apr 03; 5(179):179ra47.
journal title abbreviation: Sci Transl Med
publication date: 2013-04-03T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.
PubMed Identifier: 28860411
author list: Franses JW, Basar O, Kadayifci A, Yuksel O, Choz M, Kulkarni AS, Tai E, Vo KD, Arora KS, Desai N, Licausi JA, Toner M, Maheswaran S, Haber DA, Ryan DP, Brugge WR, Ting DT
published in: The oncologist
information resource reference: Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms. Oncologist. 2018 01; 23(1):121-127.
journal title abbreviation: Oncologist
publication date: 2017-08-31T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
PubMed Identifier: 21233348
author list: Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA
published in: Science (New York, N.Y.)
information resource reference: Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science. 2011 Feb 04; 331(6017):593-6.
journal title abbreviation: Science
publication date: 2011-01-13T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.
PubMed Identifier: 29108249
author list: Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A
published in: Oncotarget
information resource reference: STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572.
journal title abbreviation: Oncotarget
publication date: 2017-09-11T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells.
PubMed Identifier: 29170510
author list: Wong KHK, Tessier SN, Miyamoto DT, Miller KL, Bookstaver LD, Carey TR, Stannard CJ, Thapar V, Tai EC, Vo KD, Emmons ES, Pleskow HM, Sandlin RD, Sequist LV, Ting DT, Haber DA, Maheswaran S, Stott SL, Toner M
published in: Nature communications
information resource reference: Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells. Nat Commun. 2017 11 23; 8(1):1733.
journal title abbreviation: Nat Commun
publication date: 2017-11-23T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer.
PubMed Identifier: 29301747
author list: Miyamoto DT, Lee RJ, Kalinich M, LiCausi JA, Zheng Y, Chen T, Milner JD, Emmons E, Ho U, Broderick K, Silva E, Javaid S, Kwan TT, Hong X, Dahl DM, McGovern FJ, Efstathiou JA, Smith MR, Sequist LV, Kapur R, Wu CL, Stott SL, Ting DT, Giobbie-Hurder A, Toner M, Maheswaran S, Haber DA
published in: Cancer discovery
information resource reference: An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer. Cancer Discov. 2018 03; 8(3):288-303.
journal title abbreviation: Cancer Discov
publication date: 2018-01-04T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia.
PubMed Identifier: 28188229
author list: Ardeljan D, Taylor MS, Ting DT, Burns KH
published in: Clinical chemistry
information resource reference: The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia. Clin Chem. 2017 04; 63(4):816-822.
journal title abbreviation: Clin Chem
publication date: 2017-02-10T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
PubMed Identifier: 22763454
author list: Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, Ryan DP, Sequist LV, Bardeesy N, Ramaswamy S, Toner M, Maheswaran S, Haber DA
published in: Nature
information resource reference: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature. 2012 Jul 26; 487(7408):510-3.
journal title abbreviation: Nature
publication date: 2012-07-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource