PBY1PaulYuPaul B. Yu, M.D., Ph.D.42.36258150000000-71.067024000000001251Yu, PaulB.857/307-0390Charles Addison and Elizabeth Ann Sanders Associate Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10517971129533671Brittain EL, Thennapan T, Maron BA, Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C, Paulin R, Machado RF, Yu PBAmerican journal of respiratory and critical care medicineUpdate in Pulmonary Vascular Disease 2016 and 2017. Am J Respir Crit Care Med. 2018 07 01; 198(1):13-23.Am J Respir Crit Care Med2018-07-01T00:00:002018Update in Pulmonary Vascular Disease 2016 and 2017.19224917Wrighton KH, Lin X, Yu PB, Feng XHThe Journal of biological chemistryTransforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009 Apr 10; 284(15):9755-63.J Biol Chem2009-02-18T00:00:002009Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors.16003240Yu PB, Parker W, Nayak JV, Platt JLTransplantationSensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies. Transplantation. 2005 Jul 15; 80(1):102-9.Transplantation2005-07-15T00:00:002005Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies.22223731Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PBArteriosclerosis, thrombosis, and vascular biologyInhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22.Arterioscler Thromb Vasc Biol2012-01-05T00:00:002012Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.Authorship 1035973Authorship 1064790929748361Agarwal S, Spiekerkoetter E, Austin ED, de Jesus Perez V, Dezfulian C, Maron BA, Ryan JJ, Starks MA, Yu PB, Bonnet S, Perman SMCirculation researchCareer Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association. Circ Res. 2018 05 11; 122(10):1330-1333.Circ Res2018-05-11T00:00:002018Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association.19914855Hong CC, Yu PBCytokine & growth factor reviewsApplications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):409-18.Cytokine Growth Factor Rev2009-11-14T00:00:002009Applications of small molecule BMP inhibitors in physiology and disease.21393479Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PBBloodInhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 05; 117(18):4915-23.Blood2011-03-10T00:00:002011Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.29899023Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BAScience translational medicineNEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445).Sci Transl Med2018-06-13T00:00:002018NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.Authorship 10737442515286002Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KDAmerican journal of physiology. Lung cellular and molecular physiologyBMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7.Am J Physiol Lung Cell Mol Physiol2004-07-30T00:00:002004BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.23281127Komatsu Y, Yu PB, Kamiya N, Pan H, Fukuda T, Scott GJ, Ray MK, Yamamura K, Mishina YJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchAugmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. J Bone Miner Res. 2013 Jun; 28(6):1422-33.J Bone Miner Res2013-06-01T00:00:002013Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice.18682835Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CCPloS oneDorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One. 2008 Aug 06; 3(8):e2904.PLoS One2008-08-06T00:00:002008Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.Authorship 1089050230130137Graham BB, Yu PBAmerican journal of respiratory and critical care medicineFinding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019 01 01; 199(1):9-11.Am J Respir Crit Care Med2019-01-01T00:00:002019Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension.Authorship 114401123028567Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia YPloS oneHepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One. 2012; 7(9):e44622.PLoS One2012-09-13T00:00:002012Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.20855670Yeh RW, Yu PB, Drachman DECirculationTakotsubo cardiomyopathy complicated by cardiac tamponade: classic hemodynamic findings with a new disease. Circulation. 2010 Sep 21; 122(12):1239-41.Circulation2010-09-21T00:00:002010Takotsubo cardiomyopathy complicated by cardiac tamponade: classic hemodynamic findings with a new disease.19029982Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KDNature medicineBMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9.Nat Med2008-11-30T00:00:002008BMP type I receptor inhibition reduces heterotopic [corrected] ossification.Authorship 10928991030227946Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang WBioorganic & medicinal chemistry lettersDiscovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3356-3362.Bioorg Med Chem Lett2018-09-06T00:00:002018Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.23547776Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PBACS chemical biologyDevelopment of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013; 8(6):1291-302.ACS Chem Biol2013-04-30T00:00:002013Development of an ALK2-biased BMP type I receptor kinase inhibitor.Authorship 11012012730312106Nikolic I, Yung LM, Yang P, Malhotra R, Paskin-Flerlage SD, Dinter T, Bocobo GA, Tumelty KE, Faugno AJ, Troncone L, McNeil ME, Huang X, Coser KR, Lai CSC, Upton PD, Goumans MJ, Zamanian RT, Elliott CG, Lee A, Zheng W, Berasi SP, Huard C, Morrell NW, Chung RT, Channick RW, Roberts KE, Yu PBAmerican journal of respiratory and critical care medicineBone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension. Am J Respir Crit Care Med. 2019 04 01; 199(7):891-902.Am J Respir Crit Care Med2019-04-01T00:00:002019Bone Morphogenetic Protein 9 Is a Mechanistic Biomarker of Portopulmonary Hypertension.Authorship 1108623230354505Yung LM, Yu PBCirculation. Cardiovascular imagingRoom With a View. Circ Cardiovasc Imaging. 2018 08; 11(8):e008148.Circ Cardiovasc Imaging2018-08-01T00:00:002018Room With a View.Authorship 1111461330414136Dinter T, Bocobo GA, Yu PBMethods in molecular biology (Clifton, N.J.)Pharmacologic Strategies for Assaying BMP Signaling Function. Methods Mol Biol. 2019; 1891:221-233.Methods Mol Biol2019-01-01T00:00:002019Pharmacologic Strategies for Assaying BMP Signaling Function.20192017Boston Biomedical Innovator Center - DRIVE grant2018American Society of Clinical Investigation21841161Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KDBloodPerturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011 Oct 13; 118(15):4224-30.Blood2011-08-12T00:00:002011Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.Authorship 1122800230605416Yang P, Yu PBCirculation researchIn Search of the Second Hit in Pulmonary Arterial Hypertension. Circ Res. 2019 01 04; 124(1):6-8.Circ Res2019-01-04T00:00:002019In Search of the Second Hit in Pulmonary Arterial Hypertension.2021-08-31YU, PAUL B2018-09-15Repositioning AZD0530 for surgical treatment of fibrodysplasia ossificans progressivaUG3TR002617Principal Investigator20691279Boergermann JH, Kopf J, Yu PB, Knaus PThe international journal of biochemistry & cell biologyDorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Int J Biochem Cell Biol. 2010 Nov; 42(11):1802-7.Int J Biochem Cell Biol2010-08-05T00:00:002010Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.Authorship 1140043Authorship 1139152730811450Wertheim BM, Lin YD, Zhang YY, Samokhin AO, Alba GA, Arons E, Yu PB, Maron BAPloS oneIsolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials. PLoS One. 2019; 14(2):e0211909.PLoS One2019-02-27T00:00:002019Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials.D006976Disorders58115250.451795Hypertension, PulmonaryD009999Disorders1342380.790924Ossification, HeterotopicD009221Disorders49780.89868Myositis OssificansCardiovascular Research Center - CVRCCenter for Regenerative Medicine - CRMTNeuroendocrine UnitD030201Chemicals & Drugs851430.924385Activin Receptors, Type ID019485Chemicals & Drugs3638380.657763Bone Morphogenetic ProteinsAuthorship 1148757431021722Morrell NW, Upton PD, Li W, Yu PBCirculation researchLetter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension". Circ Res. 2019 04 26; 124(9):e81.Circ Res2019-04-26T00:00:002019Letter by Morrell et al Regarding Article, "Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension".Authorship 11514181031068801Padilha EC, Wang J, Kerns E, Lee A, Huang W, Jiang JK, McKew J, Mutlib A, Peccinini RG, Yu PB, Sanderson P, Xu XFrontiers in pharmacologyApplication of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). Front Pharmacol. 2019; 10:234.Front Pharmacol2019-04-24T00:00:002019Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).Developmental BiologyMedicinePediatricsRheumatologyCardiologyNephrologyEndocrinologyPulmonaryBrigham and Women's HospitalBoston Children's HospitalHarvard School of Dental MedicineMassachusetts General HospitalHTK1HenryKeutmannHenry Todd Keutmann, M.D.42.36258150000000-71.0670240000000067900Keutmann, HenryAssociate Professor of Medicine (Biochemistry)JLB10JodieBabittJodie L. Babitt, M.D.42.36125700000000-71.0655270000000031772Babitt, JodieProfessor of MedicineBL4BenjaminLederBenjamin Leder, M.D.42.36258150000000-71.0670240000000061182Leder, BenjaminProfessor of MedicineJAL42JaneLeopoldJane Anne Leopold, M.D.42.33837200000000-71.1032690000000085108Leopold, JaneAssociate Professor of MedicineRM29RajeevMalhotraRajeev Malhotra, M.D.42.36241700000000-71.0689370000000056409Malhotra, RajeevAssistant Professor of MedicineATF5AlexanderFajeAlexander Terence Faje, M.D.42.36258150000000-71.0670240000000090725Faje, AlexanderAssistant Professor of MedicineTK3TatsuyaKobayashiTatsuya Kobayashi, M.D., Ph.D.42.36258150000000-71.0670240000000039941Kobayashi, TatsuyaAssistant Professor of MedicineABW7AaronWaxmanAaron Bradley Waxman, M.D., Ph.D.42.33510370000000-71.1061649000000032766Waxman, AaronAssociate Professor of Medicine11108selected publications4.51180.00392033462research areas1.863970.019365774coauthor of61.253311.409360similar toVR7VickiRosenVicki Rosen, Ph.D.42.33611130000000-71.1008899000000033461Rosen, VickiProfessor of Developmental BiologyDBB2DonaldBlochDonald Bendit Bloch, M.D.42.37730000000000-71.0525000000000062084Bloch, DonaldAssociate Professor of MedicineKF70KeertikFulzeleKeertik Fulzele, Ph.D.42.36258150000000-71.0670240000000069696Fulzele, KeertikInstructor in MedicineIN12IvanaNikolicIvana Nikolic, M.D.42.33510370000000-71.1061649000000091020Nikolic, IvanaInstructor in MedicineAuthorship 1357811Authorship 1224110Authorship 1181927331422086Atri DS, Tsao AL, Yu PB, Berry NCJACC. Cardiovascular interventionsST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma. JACC Cardiovasc Interv. 2019 09 09; 12(17):e145-e147.JACC Cardiovasc Interv2019-08-14T00:00:002019ST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma.Authorship 12010795731661308Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NWAmerican journal of respiratory and critical care medicineCharacterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2020 03 01; 201(5):575-585.Am J Respir Crit Care Med2020-03-01T00:00:002020Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.true1Associate Professor of Medicine (Biochemistry)Associate Professor of Medicine (Biochemistry)true1Instructor in MedicineInstructor in Medicinetrue1Instructor in MedicineInstructor in Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 12125521531840004Hwang C, Marini S, Huber AK, Stepien DM, Sorkin M, Loder S, Pagani CA, Li J, Visser ND, Vasquez K, Garada MA, Li S, Xu J, Hsu CY, Yu PB, James AW, Mishina Y, Agarwal S, Li J, Levi BBone researchMesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019; 7:36.Bone Res2019-12-10T00:00:002019Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification.Authorship 1309683Authorship 1217698331952977Samokhin AO, Hsu S, Yu PB, Waxman AB, Alba GA, Wertheim BM, Hopkins CD, Bowman F, Channick RN, Nikolic I, Faria-Urbina M, Hassoun PM, Leopold JA, Tedford RJ, Ventetuolo CE, Leary PJ, Maron BAThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationCirculating NEDD9 is increased in pulmonary arterial hypertension: A multicenter, retrospective analysis. J Heart Lung Transplant. 2020 04; 39(4):289-299.J Heart Lung Transplant2019-12-31T00:00:002019Circulating NEDD9 is increased in pulmonary arterial hypertension: A multicenter, retrospective analysis.Authorship 122804715Authorship 12258741532076051Yin H, Kalra L, Lai Z, Guimaro MC, Aber L, Warner BM, Michael D, Zhang N, Cabrera-Perez J, Karim A, Swaim WD, Afione S, Voigt A, Nguyen CQ, Yu PB, Bloch DB, Chiorini JAScientific reportsInhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice. Sci Rep. 2020 02 19; 10(1):2967.Sci Rep2020-02-19T00:00:002020Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice.32083953Rochon ER, Krowka MJ, Bartolome S, Heresi GA, Bull T, Roberts K, Hemnes A, Forde KA, Krok KL, Patel M, Lin G, McNeil M, Al-Naamani N, Roman BL, Yu PB, Fallon MB, Gladwin MT, Kawut SMAmerican journal of respiratory and critical care medicineBMP9/10 in Pulmonary Vascular Complications of Liver Disease. Am J Respir Crit Care Med. 2020 06 15; 201(12):1575-1578.Am J Respir Crit Care Med2020-06-15T00:00:002020BMP9/10 in Pulmonary Vascular Complications of Liver Disease.Authorship 12446461432385263Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JHNature communicationsA RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 05 08; 11(1):2289.Nat Commun2020-05-08T00:00:002020A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.Authorship 12476892032404506Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PBScience translational medicineACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 05 13; 12(543).Sci Transl Med2020-05-13T00:00:002020ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.Authorship 1254797632552164Maron BA, Gladwin MT, Bonnet S, De Jesus Perez V, Perman SM, Yu PB, Ichinose FJournal of the American Heart AssociationPerspectives on Cardiopulmonary Critical Care for Patients With COVID-19: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. J Am Heart Assoc. 2020 07 21; 9(14):e017111.J Am Heart Assoc2020-06-18T00:00:002020Perspectives on Cardiopulmonary Critical Care for Patients With COVID-19: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation.Authorship 1271647632736145Yang P, Troncone L, Augur ZM, Kim SSJ, McNeil ME, Yu PBBoneThe role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 12; 141:115542.Bone2020-07-28T00:00:002020The role of bone morphogenetic protein signaling in vascular calcification.Authorship 12788431332813135Szulcek R, Sanchez-Duffhues G, Rol N, Pan X, Tsonaka R, Dickhoff C, Yung LM, Manz XD, Kurakula K, Kielbasa SM, Mei H, Timens W, Yu PB, Bogaard HJ, Goumans MJAngiogenesisExacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells. Angiogenesis. 2020 11; 23(4):699-714.Angiogenesis2020-08-19T00:00:002020Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells.Authorship 1485763Authorship 1293312233031025Yang P, Yu PBCirculation researchPeriostin: A Novel Integrator of Hypoxic Signaling in Pulmonary Hypertension. Circ Res. 2020 10 09; 127(9):1153-1155.Circ Res2020-10-08T00:00:002020Periostin: A Novel Integrator of Hypoxic Signaling in Pulmonary Hypertension.33320799Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD, Yang P, Bocobo GA, Nikolic I, Higuera A, Salmon RM, Jiang H, Lodge KM, Hoenderdos K, Baron RM, Yu PB, Condliffe AM, Summers C, Nourshargh S, Chilvers ER, Morrell NWAmerican journal of respiratory and critical care medicineCirculating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice. Am J Respir Crit Care Med. 2021 06 01; 203(11):1419-1430.Am J Respir Crit Care Med2021-06-01T00:00:002021Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice.33293508Hwang C, Marini S, Huber AK, Stepien DM, Sorkin M, Loder S, Pagani CA, Li J, Visser ND, Vasquez K, Garada MA, Li S, Xu J, Hsu CY, Yu PB, James AW, Mishina Y, Agarwal S, Li J, Levi BBone researchMesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019 Dec 10; 7(1):36.Bone Res2019-12-10T00:00:002019Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification.Authorship 131249215Authorship 131035918Authorship 13147011133256557Strong AL, Spreadborough PJ, Dey D, Yang P, Li S, Lee A, Haskins RM, Grimm PD, Kumar R, Bradley MJ, Yu PB, Levi B, Davis TAStem cells and developmentBMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma. Stem Cells Dev. 2021 01 15; 30(2):91-105.Stem Cells Dev2020-12-24T00:00:002020BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma.Authorship 1325537733516233Peng K, Karunakaran KD, Labadie R, Veliu M, Cheung C, Lee A, Yu PB, Upadhyay JOrphanet journal of rare diseasesSuppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva. Orphanet J Rare Dis. 2021 01 30; 16(1):54.Orphanet J Rare Dis2021-01-30T00:00:002021Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.Authorship 1331161833584642Al-Shabrawey M, Hussein K, Wang F, Wan M, Elmasry K, Elsherbiny N, Saleh H, Yu PB, Tawfik A, Ibrahim ASFrontiers in immunologyBone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells. Front Immunol. 2020; 11:568795.Front Immunol2021-01-29T00:00:002021Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells.Authorship 13372901633705358Williams E, Bagarova J, Kerr G, Xia DD, Place ES, Dey D, Shen Y, Bocobo GA, Mohedas AH, Huang X, Sanderson PE, Lee A, Zheng W, Economides AN, Smith JC, Yu PB, Bullock ANJCI insightSaracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva. JCI Insight. 2021 04 22; 6(8).JCI Insight2021-04-22T00:00:002021Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.Authorship 1363841734139597Huang X, Roeder A, Li R, Beers J, Liu C, Zou J, Yu PB, Zheng WStem cell researchGeneration of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in the ACVR1 gene. Stem Cell Res. 2021 07; 54:102424.Stem Cell Res2021-06-07T00:00:002021Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in the ACVR1 gene.34162750Cong Q, Liu Y, Zhou T, Zhou Y, Xu R, Cheng C, Chung HS, Yan M, Zhou H, Liao Z, Gao B, Bocobo GA, Covington TA, Song HJ, Su P, Yu PB, Yang YScience translational medicineA self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification. Sci Transl Med. 2021 06 23; 13(599).Sci Transl Med2021-06-23T00:00:002021A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification.Authorship 137182116Authorship 1371134334192439Yang P, Bocobo GA, Yu PBThe New England journal of medicineSotatercept for Pulmonary Arterial Hypertension. N Engl J Med. 2021 07 01; 385(1):92-93.N Engl J Med2021-07-01T00:00:002021Sotatercept for Pulmonary Arterial Hypertension.2025-05-31YU, PAUL B2021-07-15Context-specific angiogenic signaling in the pulmonary vasculatureR01HL159443Principal InvestigatorAuthorship 1841434Authorship 14147821634858325de Ruiter RD, Smilde BJ, Pals G, Bravenboer N, Knaus P, Schoenmaker T, Botman E, Sánchez-Duffhues G, Pacifici M, Pignolo RJ, Shore EM, van Egmond M, Van Oosterwyck H, Kaplan FS, Hsiao EC, Yu PB, Bocciardi R, De Cunto CL, Longo Ribeiro Delai P, de Vries TJ, Hilderbrandt S, Jaspers RT, Keen R, Koolwijk P, Morhart R, Netelenbos JC, Rustemeyer T, Scott C, Stockklausner C, Ten Dijke P, Triffit J, Ventura F, Ravazzolo R, Micha D, Eekhoff EMWFrontiers in endocrinologyFibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop. Front Endocrinol (Lausanne). 2021; 12:732728.Front Endocrinol (Lausanne)2021-11-10T00:00:002021Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.Authorship 190032Authorship 202574135050688Yang P, Yu PBCirculation researchA New Link in the Chain: Unspliced XBP1 in Wnt Signaling and Vascular Calcification. Circ Res. 2022 01 21; 130(2):230-233.Circ Res2022-01-20T00:00:002022A New Link in the Chain: Unspliced XBP1 in Wnt Signaling and Vascular Calcification.Authorship 1426588235089810Spyropoulos F, Sorrentino A, van der Reest J, Yang P, Waldeck-Weiermair M, Steinhorn B, Eroglu E, Saeedi Saravi SS, Yu P, Haigis M, Christou H, Michel TAmerican journal of physiology. Heart and circulatory physiologyMetabolomic and transcriptomic signatures of chemogenetic heart failure. Am J Physiol Heart Circ Physiol. 2022 03 01; 322(3):H451-H465.Am J Physiol Heart Circ Physiol2022-01-28T00:00:002022Metabolomic and transcriptomic signatures of chemogenetic heart failure.Authorship 6312241023646137Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock ANPloS oneA new class of small molecule inhibitor of BMP signaling. PLoS One. 2013; 8(4):e62721.PLoS One2013-04-30T00:00:002013A new class of small molecule inhibitor of BMP signaling.Authorship 14445415Authorship 14473241435482838Alenezi F, Covington TA, Mukherjee M, Mathai SC, Yu PB, Rajagopal SCirculation researchNovel Approaches to Imaging the Pulmonary Vasculature and Right Heart. Circ Res. 2022 04 29; 130(9):1445-1465.Circ Res2022-04-28T00:00:002022Novel Approaches to Imaging the Pulmonary Vasculature and Right Heart.35511419Aykul S, Huang L, Wang L, Das NM, Reisman S, Ray Y, Zhang Q, Rothman N, Nannuru KC, Kamat V, Brydges S, Troncone L, Johnsen L, Yu PB, Fazio S, Lees-Shepard J, Schutz K, Murphy AJ, Economides AN, Idone V, Hatsell SJThe Journal of clinical investigationAnti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1. J Clin Invest. 2022 06 15; 132(12).J Clin Invest2022-06-15T00:00:002022Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.Authorship 14520621935551212Joshi SR, Liu J, Bloom T, Karaca Atabay E, Kuo TH, Lee M, Belcheva E, Spaits M, Grenha R, Maguire MC, Frost JL, Wang K, Briscoe SD, Alexander MJ, Herrin BR, Castonguay R, Pearsall RS, Andre P, Yu PB, Kumar R, Li GScientific reportsSotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension. Sci Rep. 2022 05 12; 12(1):7803.Sci Rep2022-05-12T00:00:002022Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.true1Charles Addison and Elizabeth Ann Sanders Associate Professor of MedicineCharles Addison and Elizabeth Ann Sanders Associate Professor of Medicinetrue1Instructor in MedicineInstructor in MedicineAuthorship 1460556835650602Smilde BJ, Stockklausner C, Keen R, Whittaker A, Bullock AN, von Delft A, van Schoor NM, Yu PB, Eekhoff EMWBMC musculoskeletal disordersProtocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP). BMC Musculoskelet Disord. 2022 Jun 01; 23(1):519.BMC Musculoskelet Disord2022-06-01T00:00:002022Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).Authorship 1484268236154621Zhong Y, Yu PBCirculationDecoding the Link Between Inflammation and Pulmonary Arterial Hypertension. Circulation. 2022 09 27; 146(13):1023-1025.Circulation2022-09-26T00:00:002022Decoding the Link Between Inflammation and Pulmonary Arterial Hypertension.Authorship 1509032636463382Farid A, Golden E, Robicheau S, Hu A, Cheung K, Yu PB, Rutkove SB, Upadhyay JScientific reportsDiminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography. Sci Rep. 2022 12 03; 12(1):20908.Sci Rep2022-12-03T00:00:002022Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography.wec138WendyChungWendy Chung, M.D., Ph.D.214837Chung, WendyMember of the Faculty of Pediatricstrue1Professor of MedicineProfessor of MedicineAuthorship 156975118Authorship 15693994Authorship 15598002037278410Bai Y, Li G, Yung L, Yu PB, Ai XAmerican journal of physiology. Lung cellular and molecular physiologyIntrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries. Am J Physiol Lung Cell Mol Physiol. 2023 08 01; 325(2):L114-L124.Am J Physiol Lung Cell Mol Physiol2023-06-06T00:00:002023Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries.37024132Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VAThe European respiratory journalWnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. Eur Respir J. 2023 06; 61(6).Eur Respir J2023-06-08T00:00:002023Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.37279475Meng Z, Zhang S, Li W, Wang Y, Wang M, Liu X, Liu CL, Liao S, Liu T, Yang C, Lindholt JS, Rasmussen LM, Obel LM, Stubbe J, Diederichsen AC, Sun Y, Chen Y, Yu PB, Libby P, Shi GP, Guo JEuropean heart journalCationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur Heart J. 2023 08 01; 44(29):2763-2783.Eur Heart J2023-08-01T00:00:002023Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.Authorship 15918692Authorship 15865919Authorship 1581798837675636Zhong Y, Yu PBArteriosclerosis, thrombosis, and vascular biologyAngiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2023 10; 43(10):1784-1787.Arterioscler Thromb Vasc Biol2023-09-07T00:00:002023Angiogenesis Redux: An Overall Protective Role of VEGF/KDR Signaling in the Microvasculature in Pulmonary Arterial Hypertension.Authorship 4289195Authorship 1605528937942611Tzani A, Haemmig S, Cheng HS, Pérez-Cremades D, Heuschkel MA, Jamaiyar A, Singh SA, Aikawa M, Yu PB, Wang T, Sun Y, Feinberg MW, Plutzky JArteriosclerosis, thrombosis, and vascular biologyFAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2024 01; 44(1):143-155.Arterioscler Thromb Vasc Biol2023-11-09T00:00:002023FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.Authorship 1608332637993205Weber BN, Paik JJ, Aghayev A, Klein AL, Mavrogeni SI, Yu PB, Mukherjee MJournal of the American College of CardiologyNovel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement. J Am Coll Cardiol. 2023 11 28; 82(22):2128-2151.J Am Coll Cardiol2023-11-28T00:00:002023Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement.true1Research Fellow in MedicineResearch Fellow in Medicinetrue1Professor of Developmental BiologyProfessor of Developmental Biologytrue1Member of the Faculty of PediatricsMember of the Faculty of PediatricsAuthorship 295459324015338Malhotra R, Paskin-Flerlage S, Zamanian RT, Zimmerman P, Schmidt JW, Deng DY, Southwood M, Spencer R, Lai CS, Parker W, Channick RN, Morrell NW, Elliott CG, Yu PBPulmonary circulationCirculating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. Pulm Circ. 2013 Apr; 3(2):369-80.Pulm Circ2013-04-01T00:00:002013Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension.Authorship 67296814Authorship 2309554LT98LucaTronconeLuca Troncone, Ph.D.124869Troncone, LucaInstructor in MedicineAuthorship 7065221024501215Mayeur C, Lohmeyer LK, Leyton P, Kao SM, Pappas AE, Kolodziej SA, Spagnolli E, Yu B, Galdos RL, Yu PB, Peterson RT, Bloch DB, Bloch KD, Steinbicker AUBloodThe type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6. Blood. 2014 Apr 03; 123(14):2261-8.Blood2014-02-05T00:00:002014The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6.Authorship 744854924904118Wu XG, Wang Y, Wu Q, Cheng WH, Liu W, Zhao Y, Mayeur C, Schmidt PJ, Yu PB, Wang F, Xia YBloodHFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood. 2014 Aug 21; 124(8):1335-43.Blood2014-06-05T00:00:002014HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.Authorship 44586226Authorship 7449999Authorship 745000725101911Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PBJournal of medicinal chemistryStructure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 09; 57(19):7900-15.J Med Chem2014-09-04T00:00:002014Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.25100727Zhao Y, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu PB, Feng XH, Lin XThe Journal of biological chemistryC-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J Biol Chem. 2014 Sep 19; 289(38):26441-26450.J Biol Chem2014-08-06T00:00:002014C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation.Authorship 7654901125271257Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJThe Journal of pharmacology and experimental therapeuticsSpecific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J Pharmacol Exp Ther. 2014 Dec; 351(3):549-58.J Pharmacol Exp Ther2014-09-30T00:00:002014Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.25603410Malhotra R, Burke MF, Martyn T, Shakartzi HR, Thayer TE, O'Rourke C, Li P, Derwall M, Spagnolli E, Kolodziej SA, Hoeft K, Mayeur C, Jiramongkolchai P, Kumar R, Buys ES, Yu PB, Bloch KD, Bloch DBPloS oneInhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS One. 2015; 10(1):e0117098.PLoS One2015-01-20T00:00:002015Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.Authorship 621252Authorship 4026442Authorship 5020771Authorship 2627381Authorship 1311554Authorship 3357745Authorship 2072421Authorship 5315471Authorship 63232Authorship 7886726Authorship 7956531625326432Mayeur C, Kolodziej SA, Wang A, Xu X, Lee A, Yu PB, Shen J, Bloch KD, Bloch DBHaematologicaOral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015 Feb; 100(2):e68-71.Haematologica2014-10-17T00:00:002014Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation.Authorship 30405114Authorship 8150021426076038Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NWNature medicineSelective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015 Jul; 21(7):777-85.Nat Med2015-06-15T00:00:002015Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.Authorship 8348121826333933Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides ANScience translational medicineACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015 Sep 02; 7(303):303ra137.Sci Transl Med2015-09-02T00:00:002015ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.Authorship 8435695Authorship 842674426413870Wang A, Zsengellér ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SAThe Journal of clinical investigationExcess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. J Clin Invest. 2015 Nov 02; 125(11):4021-5.J Clin Invest2015-09-28T00:00:002015Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth.26410368Yung LM, Sánchez-Duffhues G, Ten Dijke P, Yu PBCardiovascular researchBone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells. Cardiovasc Res. 2015 Nov 01; 108(2):278-87.Cardiovasc Res2015-09-25T00:00:002015Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells.26473639Parikh VN, Park J, Nikolic I, Channick R, Yu PB, De Marco T, Hsue PY, Chan SYJournal of acquired immune deficiency syndromes (1999)Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection. J Acquir Immune Defic Syndr. 2015 Nov 01; 70(3):236-41.J Acquir Immune Defic Syndr2015-11-01T00:00:002015Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.Authorship 4273752Authorship 860181726461965Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KDNature reviews. CardiologyTargeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20.Nat Rev Cardiol2015-10-13T00:00:002015Targeting BMP signalling in cardiovascular disease and anaemia.Authorship 870840226029832Chun HJ, Yu PBAmerican journal of respiratory and critical care medicineElafin in pulmonary arterial hypertension. Beyond targeting elastases. Am J Respir Crit Care Med. 2015 Jun 01; 191(11):1217-9.Am J Respir Crit Care Med2015-06-01T00:00:002015Elafin in pulmonary arterial hypertension. Beyond targeting elastases.Authorship 3218059Authorship 878153227082534Nikolic I, Yu PBAmerican journal of respiratory and critical care medicineThe Role of Bone Marrow-derived Cells in Pulmonary Arterial Hypertension. What Lies Beneath? Am J Respir Crit Care Med. 2016 Apr 15; 193(8):822-4.Am J Respir Crit Care Med2016-04-15T00:00:002016The Role of Bone Marrow-derived Cells in Pulmonary Arterial Hypertension. What Lies Beneath?Authorship 523322627284788O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra RJournal of visualized experiments : JoVECalcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016 05 31; (111).J Vis Exp2016-05-31T00:00:002016Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation.Authorship 88692116Authorship 8867651626760925Szulcek R, Happé CM, Rol N, Fontijn RD, Dickhoff C, Hartemink KJ, Grünberg K, Tu L, Timens W, Nossent GD, Paul MA, Leyen TA, Horrevoets AJ, de Man FS, Guignabert C, Yu PB, Vonk-Noordegraaf A, van Nieuw Amerongen GP, Bogaard HJAmerican journal of respiratory and critical care medicineDelayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage. Am J Respir Crit Care Med. 2016 06 15; 193(12):1410-20.Am J Respir Crit Care Med2016-06-15T00:00:002016Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.Authorship 888169927006450Aghamohammadzadeh R, Zhang YY, Stephens TE, Arons E, Zaman P, Polach KJ, Matar M, Yung LM, Yu PB, Bowman FP, Opotowsky AR, Waxman AB, Loscalzo J, Leopold JA, Maron BAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyUp-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J. 2016 07; 30(7):2511-27.FASEB J2016-03-22T00:00:002016Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension.2Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor4Instructor5Other FacultyAuthorship 8963856Authorship 896386827115515Yung LM, Nikolic I, Paskin-Flerlage SD, Pearsall RS, Kumar R, Yu PBAmerican journal of respiratory and critical care medicineA Selective Transforming Growth Factor-ß Ligand Trap Attenuates Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 01; 194(9):1140-1151.Am J Respir Crit Care Med2016-11-01T00:00:002016A Selective Transforming Growth Factor-ß Ligand Trap Attenuates Pulmonary Hypertension.Authorship 9096622012-03-31YU, PAUL B2006-04-01The role of the BMP type II receptor in vascular functionK08HL0799432021-04-30YU, PAUL B2016-07-15Molecular imaging of angiogenic activity in pulmonary arterial hypertensionR01HL1319102023-06-30YU, PAUL B2010-08-01Molecular and cellular mechanisms of heterotopic ossificationR01AR057374Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 8511610YZ268YingZhongYing Zhong, Ph.D.153870Zhong, YingResearch Fellow in MedicineAuthorship 50426718Authorship 9372491727881824Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PBScience translational medicineTwo tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016 11 23; 8(366):366ra163.Sci Transl Med2016-11-23T00:00:002016Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.Authorship 2223322Authorship 951230928090291DuBrock HM, Rodriguez-Lopez JM, LeVarge BL, Curry MP, VanderLaan PA, Zsengeller ZK, Pernicone E, Preston IR, Yu PB, Nikolic I, Xu D, Thadhani RI, Channick RN, Ananth Karumanchi SPulmonary circulationMacrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension. Pulm Circ. 2016 Dec; 6(4):498-507.Pulm Circ2016-12-01T00:00:002016Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension.20132008Howard Hughes Medical Institute Physician Scientist Early Career Award20072005GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Young Investigator20112006Pulmonary Hypertension Association Mentored Clinical Scientist Award20112009Harvard Stem Cell Institute Seed Grant20152010Fondation Leducq Transatlantic Network Award20092008Massachusetts Technology Transfer Center Investigation Award75 Francis StBrigham and WomenThorn 1219A75 Francis StBoston02115MA11233908Parker W, Stitzenberg KB, Yu PB, Pratt VS, Nakamura YC, Farel LS, Ward CM, Lin SS, Everett ML, Platt JLTransplantationBiophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation. Transplantation. 2001 Feb 15; 71(3):440-6.Transplantation2001-02-15T00:00:002001Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation.19717565De Rosa L, Antonini D, Ferone G, Russo MT, Yu PB, Han R, Missero CThe Journal of biological chemistryp63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem. 2009 Oct 30; 284(44):30574-82.J Biol Chem2009-08-28T00:00:002009p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.23243027Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo JCancer research?Np63a-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013 Jan 15; 73(2):1020-30.Cancer Res2012-12-14T00:00:002012?Np63a-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.10460828Parker W, Lin SS, Yu PB, Sood A, Nakamura YC, Song A, Everett ML, Platt JLGlycobiologyNaturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies. Glycobiology. 1999 Sep; 9(9):865-73.Glycobiology1999-09-01T00:00:001999Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies.8943428Yu PB, Holzknecht ZE, Bruno D, Parker W, Platt JLJournal of immunology (Baltimore, Md. : 1950)Modulation of natural IgM binding and complement activation by natural IgG antibodies: a role for IgG anti-Gal alpha1-3Gal antibodies. J Immunol. 1996 Dec 01; 157(11):5163-8.J Immunol1996-12-01T00:00:001996Modulation of natural IgM binding and complement activation by natural IgG antibodies: a role for IgG anti-Gal alpha1-3Gal antibodies.18042551Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KDThe Journal of biological chemistryBone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem. 2008 Feb 15; 283(7):3877-88.J Biol Chem2007-11-27T00:00:002007Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells.9258770Parker W, Yu PB, Holzknecht ZE, Lundberg K, Buckley RH, Platt JLJournal of clinical immunologySpecificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J Clin Immunol. 1997 Jul; 17(4):311-21.J Clin Immunol1997-07-01T00:00:001997Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development.11161973Gonzalez-Stawinski GV, Yu PB, Love SD, Parker W, Davis RDClinical immunology (Orlando, Fla.)Hapten-induced primary and memory humoral responses are inhibited by the infusion of anti-CD20 monoclonal antibody (IDEC-C2B8, Rituximab). Clin Immunol. 2001 Feb; 98(2):175-9.Clin Immunol2001-02-01T00:00:002001Hapten-induced primary and memory humoral responses are inhibited by the infusion of anti-CD20 monoclonal antibody (IDEC-C2B8, Rituximab).Authorship 991133428629737Alessi Wolken DM, Idone V, Hatsell SJ, Yu PB, Economides ANBoneThe obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva. Bone. 2018 04; 109:210-217.Bone2017-06-16T00:00:002017The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.Authorship 995279528668522Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TATranslational research : the journal of laboratory and clinical medicineThe traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017 08; 186:95-111.Transl Res2017-06-15T00:00:002017The traumatic bone: trauma-induced heterotopic ossification.17470703D'Avila A, Ptaszek LM, Yu PB, Walker JD, Wright C, Noseworthy PA, Myers A, Refaat M, Ruskin JNCirculationImages in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale. Circulation. 2007 May 01; 115(17):e432-3.Circulation2007-05-01T00:00:002007Images in cardiovascular medicine. 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J Bone Miner Res. 2010 Feb; 25(2):200-10.J Bone Miner Res2010-02-01T00:00:002010Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.18684712Fukuda T, Kohda M, Kanomata K, Nojima J, Nakamura A, Kamizono J, Noguchi Y, Iwakiri K, Kondo T, Kurose J, Endo K, Awakura T, Fukushi J, Nakashima Y, Chiyonobu T, Kawara A, Nishida Y, Wada I, Akita M, Komori T, Nakayama K, Nanba A, Maruki Y, Yoda T, Tomoda H, Yu PB, Shore EM, Kaplan FS, Miyazono K, Matsuoka M, Ikebuchi K, Ohtake A, Oda H, Jimi E, Owan I, Okazaki Y, Katagiri TThe Journal of biological chemistryConstitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J Biol Chem. 2009 Mar 13; 284(11):7149-56.J Biol Chem2008-08-06T00:00:002008Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.Authorship 10012661828716575Agarwal S, Loder SJ, Breuler C, Li J, Cholok D, Brownley C, Peterson J, Hsieh HH, Drake J, Ranganathan K, Niknafs YS, Xiao W, Li S, Kumar R, Tompkins R, Longaker MT, Davis TA, Yu PB, Mishina Y, Levi BMolecular therapy : the journal of the American Society of Gene TherapyStrategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. 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Curr Mol Biol Rep. 2015 Dec; 1(4):175-188.Curr Mol Biol Rep2015-10-10T00:00:002015Contributions of muscle-resident progenitor cells to homeostasis and disease.15883158Yu PB, Beppu H, Kawai N, Li E, Bloch KDThe Journal of biological chemistryBone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem. 2005 Jul 01; 280(26):24443-50.J Biol Chem2005-05-09T00:00:002005Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells.17472960Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HYThe Journal of biological chemistryRepulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. 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